Mini-Reviews in Medicinal Chemistry

Article	Citations
Chemistry and Reactivity of 4-hydroxy-2-nonenal (HNE) in Model Biological Systems	105
Targeting Lysosomes: A Strategy Against Chemoresistance in Cancer	70
The Role of IL-6 Released During Exercise to Insulin Sensitivity and Muscle Hypertrophy	63
A Review on Chemical Structures and Biological Activities of Dopamine Derivatives from Medicinal Insects	58
Natural Products Databases for Drug Design	55
Protein and Small-Molecule Leucopoiesis and Thrombopoiesis Stimulators	55
Hypericin Ameliorates Maternal Separation-Induced Cognitive Deficits and Hippocampal Inflammation in Rats	48
Multi-Target Drug Design of Anti-Alzheimer’s Disease based on Tacrine	47
Comprehensive Update on Synthetic Aspects of Bosentan Derivatives	44
Current Insight on the Role of Glucokinase and Glucokinase Regulatory Protein in Diabetes	43
A Review on Rotenoids: Purification, Characterization and its Biological Applications	41
Quinoxaline: A Chemical Moiety with Spectrum of Interesting Biological Activities	40
Recent Developments in Tacrine-based Hybrids as a Therapeutic Option for Alzheimer’s Disease	39
Aptamers Against COVID-19: An Untested Opportunity	39
Multitarget Directed Ligand Approaches for Alzheimer’s Disease: A Comprehensive Review	38
An Insight into the Combat Strategies for the Treatment of Type 2 Diabetes Mellitus	38
Synthetic Approach to Potential Anticancer Benzimidazole Derivatives: A Review	37
Benefits of Manuka Honey in the Management of Infectious Diseases: Recent Advances and Prospects	37
Ferroptosis Inhibitors as Potential New Therapeutic Targets for Cardiovascular Disease	36
Current Perspective of Synthesis of Medicinally Relevant Benzothiazole based Molecules: Potential for Antimicrobial and Anti-Inflammatory Activities	36
Meet the Editorial Board Member	35
Meet the Editorial Board Member	33
Chemotherapeutic Strategies for Combating Staphylococcus aureus Infections	31
Meet the Editorial Board Member	31
The most Recent Compilation of Reactions of Enaminone Derivatives with various Amine Derivatives to Generate Biologically Active Compounds	31

Meet the Editorial Board Member	30
Bioactive Sulfonamides Derived from Amino Acids: Their Synthesis and Pharmacological Activities	29
Advances in Exercise Therapy in Hemodialysis: A Systematic Review	29
A Mini Review on Emerging Targets and Approaches for the Synthesis of Anti-viral Compounds: In Perspective to COVID-19	28
Bioactive Flavonoids: A Comparative Overview of the Biogenetic and Chemical Synthesis Approach	27
Recent Advances in Natural Products with Antiviral Activities	26
Anticancer Potential of Coumarin and its Derivatives	26
Revolutionizing Playing with Skeleton Atoms: Molecular Editing Surgery in Medicinal Chemistry	26
The Critical Function of microRNAs in Developing Resistance against 5- Fluorouracil in Cancer Cells	25
Role of TBK1 Inhibition in Targeted Therapy of Cancer	25
Associate Editorial Board Members	25
Meet the Editorial Board Member	25
Irisin and Energy Metabolism and the Role of Irisin on Metabolic Syndrome	25
KRAS Pathway-based Therapeutic Approaches in Pancreatic Cancer	25
Cinnamic Acid Derivatives: Recent Discoveries and Development Strategies for Alzheimer’s Disease	24
Research Progress in Alpha-fetoprotein-induced Immunosuppression of Liver Cancer	24
Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor- Kappa B (NF-kB) Inhibitors	23
Recent Advancements in Strategies for Abnormal Protein Clearance in Alzheimer's Disease	22
Molecular Insights on the Therapeutic Effect of Selected Flavonoids on Diabetic Neuropathy	22
A Review on Acridines as Antiproliferative Agents	21
The Pivotal Function of SLC16A1 and SLC16A1-AS1 in Cancer Progress: Molecular Pathogenesis and Prognosis	21
Meet the Section Editor	20
The Role of MiR-29 in the Mechanism of Fibrosis	20
Natural Products with BACE1 and GSK3β Inhibitory Activity	20
Inhibitory Activities of Pyrazolo-Oxazine Heterocyclic Derivatives	20
Antioxidant, Anti-inflammatory, Antibacterial, and Analgesic Activities and Mechanisms of Quinolines, Indoles and Related Derivatives	19
Recent Advances in Nanobiotechnology for the Treatment of Non-Hodgkin’s Lymphoma	19
Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships	18
AGAP2-AS1: An Indispensable lncRNA in Tumors	18
Meet the Editorial Board Member	18
Pharmacological Efficacy and Safety of Glycyrrhiza glabra in the Treatment of Respiratory Tract Infections	18
Ferulic Acid and Cardiovascular Health: Therapeutic and Preventive Potential	18
Meet the Editorial Board Member	18
Meet Our Editorial Board Member	18
Meet the Frontiers Section Editor	18
Reviewing Propolis with Multi-components in the Treatment of Oral Diseases through Multi-pathways and Multi-targets	18
Drug Solubilization by Surfactants: Experimental Methods and Theoretical Perspectives	17
Glitazones, PPAR-γ and Neuroprotection	17
Exploring the Therapeutic Potential of Green Tea (Camellia sinensis L.) in Anti-Aging: A Comprehensive Review of Mechanisms and Findings	17
A Critical Review on Recent Development of Techniques and Drug Targets in the Management of Breast Cancer	17
Recent Literature on the Synthesis of Thiazole Derivatives and their Biological Activities	17
Quinoline Derivatives as Promising Scaffolds for Antitubercular Activity: A Comprehensive Review	17
Nimbolide: A Potential Phytochemical Agent in Multimodal Pancreatic Cancer Therapies	16
Recent Advances in the Development of Type 2 Sodium-Glucose Cotransporter Inhibitors for the Treatment of Type 2 Diabetes Mellitus	16
Roles of Accelerated Molecular Dynamics Simulations in Predictions of Binding Kinetic Parameters	16
Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?	16
Development of Mycobacterium tuberculosis Enoyl Acyl Reductase (InhA) Inhibitors: A Mini-Review	16
Meet the Editorial Board Member	16
Carbohydrazide Analogues: A Review of Synthesis and Biological Activities	16
SET Protein in Cancer: A Potential Therapeutic Target	16

Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships	15
MicroRNAs and Efferocytosis: Implications for Diagnosis and Therapy	15
Curcumin: An Insight into Molecular Pathways Involved in Anticancer Activity	15
The Utilization and Development of Viral Vectors in Vaccines as a Prophylactic Treatment Against Ebola Virus as an Emerging and Zoonotic Infectious Disease	15
Current Status of and Perspectives on Radiolabelled Ubiquicidin 29-41 Derivatives for Bacterial Infection Imaging	15
N-Methyl-D-Aspartate (NMDA)-Type Glutamate Receptors and Demyelinating Disorders: A Neuroimmune Perspective	15
The Effects of Increased Glucose Level and Glycolysis on SARS CoV-2 Infection	15
Adhatoda vasica (Nees.): A Review on its Botany, Traditional uses, Phytochemistry, Pharmacological Activities and Toxicity	14
Drug Repurposing: A Conduit to Unravelling Metabolic Reprogramming for Cancer Treatment	14
Flavonoid-metal ion Complexes as Potent Anticancer Metallodrugs: A Comprehensive Review	14
Meet the Editorial Board Member	13
Meet the Editorial Board Member	13
Effects of Urtica dioica on Metabolic Profiles in Type 2 Diabetes: A Systematic Review and Meta-analysis of Clinical Trials	13
Meet the Editor-in-Chief	13
Recent Updates on Sinularia Soft Coral	13
Meet the Editorial Board Member	13
Chemical Strategies Toward Prodrugs and Fluorescent Probes for Gasotransmitters	13
Meet the Editorial Board Member	13
A Comprehensive Review on Chemistry and Biology of Tafamidis in Transthyretin Amyloidosis	13
Therapeutic Potentials of Aconite-like Alkaloids: Bioinformatics and Experimental Approaches	12
The Complex Roles of DNA Repair Pathways, Inhibitors, Hyperthermia, and Contact Inhibition in Cell Cycle Halts	12
Comprehensive Insight into Green Synthesis Approaches, Structural Activity Relationship, and Therapeutic Potential of Pyrazolic Chalcone Derivative	12
Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi	12
Medicinal and Biological Significance of Phenoxazine Derivatives	12
Glycyrrhizin as a Potential Treatment for the Novel Coronavirus (COVID-19)	12
Strategies in Taxol Development: A Review	12
Human Galectin-1 in Multiple Cancers: A Privileged Molecular Target in Oncology	12
Inhibitors Targeting Hepatitis C Virus (HCV) Entry	12
Overview of the Biological Activities of Pyrimido[4,5-d]pyrimidines	12
An Overview of Pyridazinone Analogs: Chemical and Pharmacological Potential	12
Second-line Therapy for Helicobacter Pylori Eradication: State of the Art	11
The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex® - A Cannabis-derived Spray	11
Use of Chitosan as a Precursor for Multiple Applications in Medicinal Chemistry: Recent Significant Contributions	11
A Critical Observation on the Design and Development of Reported Peptide Inhibitors of DENV NS2B-NS3 Protease in the Last Two Decades	11
Meet the Editorial Board Member	11
Uncovering the Potential of Lipid Drugs: A Focus on Transient Membrane Microdomain-targeted Lipid Therapeutics	11
Meet the Editorial Board Member	11
Chemistry, Analysis, and Biological Aspects of Daprodustat, A New Hypoxia Inducible Factor Prolyl Hydroxylase Inhibitor: A Comprehensive Review	11
Therapeutic Approaches for the Treatment of Interstitial Lung Disease: An Exploratory Review on Molecular Mechanisms	11
The Application of the Pyrazole Structure in the Structural Modification of Natural Products	11
Meet the Editorial Board Member	11
Energy Metabolism Behavior and Response to Microenvironmental Factors of the Experimental Cancer Cell Models Differ from that of Actual Human Tumors	11
The Search for Antidotes Against Ricin	11
Indole-3-carbinol (I3C) as Leukemia Therapeutic Agents: Review	11
Chlorogenic Acid Derivatives: Structural Modifications, Drug Design, and Biological Activities: A Review	11
In vivo Pharmacokinetic and ADMET Profiles of Synthetic Antimicrobial Peptides (AMPs)	11
The Situation of Small Molecules Targeting Key Proteins in combatting SARS-CoV-2: Synthesis, Metabolic Pathway, Mechanism of Action, and Potential Therapeutic Applications	11
A Therapeutic Journey of Potential Drugs Against COVID-19	11
Meet the Editorial Board Member	11
Nutraceuticals, a Bridge Between Past and Future: Focus on Mushrooms Biological Activities and Myco-Chemistry	10
Melatonin and Related Compounds as Antioxidants	10
A Review on a Medicinal and Edible Plant: Aralia elata (Miq.) Seem.	10
Current Biomedical and Diagnostic Applications of Gold Micro and Nanoparticles	10
New Insights into the Modifications and Bioactivities of Indole-3- Carboxaldehyde and its Derivatives as a Potential Scaffold for Drug Design: A Mini-Review	10
Recent Insights of Metformin on Hepatocellular Carcinoma (HCC)	10
Xanthone: Potential Acetylcholinesterase Inhibitor for Alzheimer's Disease Treatment	10
Role of Cathepsin B in Cancer Progression: A Potential Target for Coordination Compounds	10
Recent Advancements and SAR Studies of Synthetic Coumarins as MAO-B Inhibitors: An Updated Review	10
Novel Niacin Receptor Agonists: A Promising Strategy for the Treatment of Dyslipidemia	10
Exploring the Versatility of Azine Derivatives: A Comprehensive Review on Synthesis and Biological Applications	10
Narrative Review of the Pharmacodynamics, Pharmacokinetics, and Toxicities of Illicit Synthetic Cannabinoid Receptor Agonists	10
The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases	10
Radical Releasing Anti-tuberculosis Agents and the Treatment of Mycobacterial Tuberculosis Infections - An Overview	10
Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing	10
The Role of Genetics and Synergistic Effect of Targeting Common Genetic Mutations in Acute Lymphoblastic Leukemia (ALL)	10
Aloe-emodin: Progress in Pharmacological Activity, Safety, and Pharmaceutical Formulation Applications	10
Anthriscus sylvestris: An overview on Bioactive Compounds and Anticancer Mechanisms from a Traditional Medicinal Plant to Modern Investigation	10
Peroxisome Proliferator-activated Receptor-γ As A Novel and Promising Target For Treating Cancer Via Regulation of Inflammation: A Brief Review	9
Meet the Editor in Chief	9
Advances in Biocatalytic Synthesis, Pharmacological Activities, Pharmaceutical Preparation and Metabolism of Ginsenoside Rh2	9
Acknowledgements to Reviewers	9
Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity	9
PRISMA Based Systematic Review: Pharmacognostic Study of Zanthoxylum armatum DC.	9
A Short Review on Glucogallin and its Pharmacological Activities	9
Meet the Editorial Board Member	9
Protective Effect of Plumeria Pudica Latex Proteins on Intestinal Mucositis Induced by 5-Fluorouracil	9
Some Scaffolds as Anti-leishmanial Agents: A Review	9
Targeting Bcl-2 with Indole Scaffolds: Emerging Drug Design Strategies for Cancer Treatment	9
Anticancer Potential of Naringenin, Biosynthesis, Molecular Target, and Structural Perspectives	9
Agent in Urgent Need of Clinical Practice: Corilagin	9

Meet the Executive Guest Editor	9
Modulation of Long Non-coding RNAs by Different Classes of Secondary Metabolites from Plants: A Mini-review on Antitumor Effects	9
Antioxidant Activity of 1,2,4-Triazole and its Derivatives: A Mini-Review	9
Meet the Editorial Board Member	9
Nicotinamide Adenine Dinucleotide in the Development and Treatment of Cardiac Remodeling and Aging	9
Anticancer Natural Products with Collateral Sensitivity: A Review	8
Meet the Co-Editor	8
Natural and Synthetic Phosphodiesterase Inhibitors in 2023: an Update on the Impact on Neurological and Psychiatric Conditions	8
Elucidating the Drug Repurposing Spectra of COVID-19 with its Analogues SARS and MERS	8
Systematic Review of the Serotonergic System in the Pathophysiology of Severe Dengue: The Theory of Thrombocytopenia and Vascular Extravasation	8
Recent Advances in the Development of Chemotherapeutic Agents for Malaria	8
MCM3AP-AS1: A LncRNA Participating in the Tumorigenesis of Cancer Through Multiple Pathways	8
The Indispensable Roles of GMDS and GMDS-AS1 in the Advancement of Cancer: Fucosylation, Signal Pathway and Molecular Pathogenesis	8
Recent Studies on the Pharmacological Activities and Structural Modifications of Compound-K	8
Bioactivities of Dietary Polyphenols and Their Effects on Intestinal Microbiota	8
LncRNA DSCAM-AS1: A Pivotal Therapeutic Target in Cancer	8
Recent Progress Towards Vaccines and Antibody-based Therapies Against Alzheimer's Disease	8
An Updated Review of Various Medicinal Applications of p-Co umaric Acid: From Antioxidative and Anti-Inflammatory Properties to Effects on Cell Cycle and Proliferation	8
Meet the Editorial Board Member	8
Levothyroxine and Non-alcoholic Fatty Liver Disease: A Mini Review	8
Fungal Endophytes: A Storehouse of Bioactive Compounds	8
Biological Activities of Morita-Baylis-Hillman Adducts (MBHA)	8
Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment	8
Lyophilization of Molecular Biology Reactions: A Review	7
An Updated and Focused Review on Heterocyclic Inhibitors for SARSCoV and SARS-CoV-2 3CLpro	7
Comparative Review of Effects of Pien Tze Huang and AnGong NiuHuang Pill and their Potential on Treatment of Central Nervous System Diseases	7
ZFPM2-AS1: An Oncogenic Long Non-coding RNA in Multiple Cancer Types	7
Novel GABAA Agonist Entities: Pharmacological Investigation and Molecular Modeling Study of Thiazolo- and Thiadiazolo-[3,2-a][1,3]diazepine Analogs	7
The Role of 3'UTR of RNA Viruses on mRNA Stability and Translation Enhancement	7
Acknowledgement to Reviewers	7
Acknowledgements to Reviewers	7
Dendrobine: A neuroprotective Sesquiterpenic Alkaloid for the Prevention and Treatment of Diseases: A Review	7
Recent Advances in Small Molecular PET Tracers for Pancreatic Cancer Diagnosis: Preclinical Stage	7
Meet the Editorial Board Member	7
Dietary Intake of Hydrolyzable Tannins and Condensed Tannins to Regulate Lipid Metabolism	7
The Emergence of N. sativa L. as a Green Antifungal Agent	7
The Role of Renin-Angiotensin System in Diabetic Nephropathy: An Update	7
Brassica oleracea var. capitata f. alba: A Review on its Botany, Traditional uses, Phytochemistry and Pharmacological Activities	7
Meet the Associate Editorial Board Member	7
Meet the Associate Editorial Board Member	7
Cathepsin B-A Neuronal Death Mediator in Alzheimer’s Disease Leading to Neurodegeneration	7
The Use of Nanocarriers to Enhance the Anti-neuroinflammatory Potential of Dietary Flavonoids in Animal Models of Neurodegenerative Diseases: A Systematic Review	7
Research Progress of Tamarixetin and its Glycosides	7
Therapeutic Potential of Thiophene Compounds: A Mini-Review	7
Pyridine Moiety: An Insight into Recent Advances in the Treatment of Cancer	7
Role of Caffeine in the Age-related Neurodegenerative Diseases: A Review	7
Meet the Section Editor	7
Recent Advances in Fluorescent Probes for G-quadruplex DNAs / RNAs	7
Alzheimer's Disease and Cancer: Common Targets	7
MicroRNA: A Potential Diagnosis for Male Infertility	6
The Role of Epigenetic Mechanisms in Autoimmune, Neurodegenerative, Cardiovascular, and Imprinting Disorders	6
Emerging Role of Terpenoids for the Treatment of Cancer: A Review	6
Exploration of Potent Multi-target-directed-ligands as Anti-alzheimer’s Disease Agents: A Moiety Based Review	6
Anti-aging Natural Compounds and their Role in the Regulation of Metabolic Pathways Leading to Longevity	6
Antidiabetic Properties of Dietary Chrysin: A Cellular Mechanism Review	6
The Progress of Small Molecule Targeting BCR-ABL in the Treatment of Chronic Myeloid Leukemia	6
Cytotoxic Activity of Tropane Alkaloides of Species of Erythroxylum	6
Biodegradable Polymers and their Applications: A Review	6
Withdrawal: Advances in Development of Drugs for Chronic Myelogenous Leukemia	6
Gastrointestinal, Liver, Pancreas, Oral and Psychological Long-term Symptoms of COVID-19 After Recovery: A Review	6
A Concise and Useful Guide to Understand How Alpha1 Adrenoceptor Antagonists Work	6
Promising Enzymes for Inhibitors Development Against COVID-19	6
Developments in the Antitumor Activity, Mechanisms of Action, Structural Modifications, and Structure-Activity Relationships of Steroidal Saponins	6
Meet the Editorial Board Member	6
A New Mode of Thinfilm and Nanofiber for Burst Release of the Drug for Alzheimer Disease; A Complete Scenario from Dispersible Polymer to Formulation Methodology	6
Recent Applications of Azo Dyes: A Paradigm Shift from Medicinal Chemistry to Biomedical Sciences	6
Nuclear Medicine Application of Pentixafor/Pentixather Targeting CXCR4 for Imaging and Therapy in Related Disease	6
Cyclin-Dependent Kinase 4/6 Inhibitors Against Breast Cancer	6
Meet the Editorial Board Member	6
Meet the Section Editor	6
The Therapeutic Potential of Purinergic Receptors in Alzheimer’s Disease and Promising Therapeutic Modulators	6
1,3,5-Triazine: Recent Development in Synthesis of its Analogs and Biological Profile	6
Phage-choline Kinase Inhibitor Combination to Control Pseudomonas aeruginosa: A Promising Combo	6
Mitochondrial Proteins as Metabolic Biomarkers and Sites for Therapeutic Intervention in Primary and Metastatic Cancers	6
Effects of Green Tea (−)-Epigallocatechin-3-Gallate (EGCG) on Cardiac Function - A Review of the Therapeutic Mechanism and Potentials	6
Mini-Review on Vitamin D in Pediatric Population and its Role in Respiratory and Atopic Disorders	6
Chitosan: Applications in Drug Delivery System	6
Recent Progress of Bioactivities, Mechanisms of Action, Total Synthesis, Structural Modifications and Structure-activity Relationships of Indole Derivatives: A Review	6
MiRNAs: Emerging Agents for Therapeutic Effects of Polyphenols on Ovarian Cancer	6
In silico Approaches for Exploring the Pharmacological Activities of Benzimidazole Derivatives: A Comprehensive Review	6
Acknowledgements to Reviewers	6
2-Substituted-mercapto-quinazolin-4(3H)-ones as DHFR Inhibitors	6
Osthole: Synthesis, Structural Modifications, and Biological Properties	6
Exploring Genetic Silencing: RNAi and CRISPR-Cas Potential against Drug Resistance in Malaria	6
Selenium and Computational Studies	6
Preface	5
Meet Our Associate Editorial Board Member	5
Effectiveness of Azithromycin as Add-on Therapy in COVID-19 Management	5
Perspectives on Agmatine Neurotransmission in Acute and Chronic Stressrelated Conditions	5
Advances in Pyrazole Based Scaffold as Cyclin-dependent Kinase 2 Inhibitors for the Treatment of Cancer	5
An Update on Extemporaneous Preparation of Radiopharmaceuticals Using Freeze-Dried Cold Kits	5
Meet the Editorial Board Member	5
Resistance to Intervention: Paclitaxel in Breast Cancer	5
Interaction of Dehydrogenase Enzymes with Nanoparticles in Industrial and Medical Applications, and the Associated Challenges: A Mini-review	5
Insight in Quinazoline-based HDAC Inhibitors as Anti-cancer Agents	5