Mini-Reviews in Medicinal Chemistry

Article	Citations
Parkinson’s Disease: A Review from Pathophysiology to Treatment	109
Biological Nanofactories: Using Living Forms for Metal Nanoparticle Synthesis	87
The Roles of Flavonols/Flavonoids in Neurodegeneration and Neuroinflammation	85
Potent Acetylcholinesterase Inhibitors: Potential Drugs for Alzheimer’s Disease	73
Anticancer Potential of Coumarin and its Derivatives	69
Thiosemicarbazones as Potent Anticancer Agents and their Modes of Action	67
Benzimidazole: A Milestone in the Field of Medicinal Chemistry	65
From Antibacterial to Antitumour Agents: A Brief Review on The Chemical and Medicinal Aspects of Sulfonamides	49
Antiviral Activities of Pyridine Fused and Pyridine Containing Heterocycles, A Review (from 2000 to 2020)	42
Monoterpenes: Essential Oil Components with Valuable Features	42
Resistance to Intervention: Paclitaxel in Breast Cancer	39
Novel Hybrid Molecules Based on triazole-β-lactam as Potential Biological Agents	37
The Role of EGCG in Breast Cancer Prevention and Therapy.	36
Recent Applications of Azo Dyes: A Paradigm Shift from Medicinal Chemistry to Biomedical Sciences	34
Ferulic Acid and Cardiovascular Health: Therapeutic and Preventive Potential	34
Current and Advanced Nanomaterials in Dentistry as Regeneration Agents: An Update	33
Recent Progress in Anticancer Agents Incorporating Pyrazole Scaffold	33
Medicinal Plants in the Treatment of Peptic Ulcer Disease: A Review	33
Herbal Drugs and Natural Products in the light of Nanotechnology and Nanomedicine for Developing Drug Formulations	32
Plumbagin: A Potential Anti-cancer Compound	32
Medicinal Thiols: Current Status and New Perspectives	32
Applications of Quantitative Structure-Activity Relationships (QSAR) based Virtual Screening in Drug Design: A Review	31
Osthole: A Multifunctional Natural Compound with Potential Anticancer, Antioxidant and Anti-inflammatory Activities	30
An Appraisal of Current Pharmacological Perspectives of Sesamol: A Review	30
Pharmacological Actions and Underlying Mechanisms of Catechin: A Review	29

Fenugreek Cultivation with Emphasis on Historical Aspects and its uses in Traditional Medicine and Modern Pharmaceutical Science	29
Paeonol Derivatives and Pharmacological Activities: A Review of Recent Progress	27
Recent Advancements on Benzimidazole: A Versatile Scaffold in Medicinal Chemistry	27
Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives	26
A Review on Anticancer Activities of Thiophene and Its Analogs	26
Lignans from Medicinal Plants and their Anticancer Effect	26
Advancement in Pharmacological Activities of Benzothiazole and its Derivatives: An Up to Date Review	26
Recent Developments of Target Based Coumarin Derivatives as Potential Anticancer Agents	25
Traditional Uses, Therapeutic Effects and Recent Advances of Curcumin: A Mini-Review	25
Imidazole Derivatives and their Antibacterial Activity – a Mini-Review	25
Isatin: A Scaffold with Immense Biodiversity	25
A Recent Appraisal of Artificial Intelligence and In Silico ADMET Prediction in the Early Stages of Drug Discovery	25
Psoralen: A Biologically Important Coumarin with Emerging Applications	24
Advances in Anti-inflammatory Activity, Mechanism and Therapeutic Application of Ursolic Acid	23
Anticancer and Antimicrobial Activities of Naproxen and Naproxen Derivatives	23
Zinc Poisoning - Symptoms, Causes, Treatments	23
Quinoline: An Attractive Scaffold in Drug Design	23
Influence of Plant Bioactive Compounds on Intestinal Epithelial Barrier in Poultry	22
A Panoramic Review of Benzimidazole Derivatives and their Potential Biological Activity	22
Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity	21
An Updated Review of Various Medicinal Applications of p-Co umaric Acid: From Antioxidative and Anti-Inflammatory Properties to Effects on Cell Cycle and Proliferation	20
Current Trends in Drug Delivery System of Curcumin and its Therapeutic Applications	20
An Updated Review of Secondary Metabolites from Marine Fungi	20
Curcumin: An Insight into Molecular Pathways Involved in Anticancer Activity	20
Thymoquinone: A Review on its Pharmacological Importance, and its Association with Oxidative Stress, COVID-19, and Radiotherapy	20
Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity	19
Medicinal Plant Centipeda Minima: A Resource of Bioactive Compounds	19
Update on Acrylic Resins Used in Dentistry	19
Thiosemicarbazides: Updates on Antivirals Strategy	19
Antioxidant, Anti-inflammatory, Antibacterial, and Analgesic Activities and Mechanisms of Quinolines, Indoles and Related Derivatives	19
Antimicrobial Properties of Mandelic Acid, Gallic Acid and their Derivatives	19
Structure-Activity Relationships of Natural and Synthetic Indole-Derived Scaffolds as α-Glucosidase Inhibitors: A Mini-Review	19
New Development of Novel Berberine Derivatives against Bacteria	19
Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi	18
The Advances on the Protective Effects of Ginsenosides on Myocardial Ischemia and Ischemia-Reperfusion Injury	18
Therapeutic Journey of Andrographis paniculata (Burm.f.) Nees from Natural to Synthetic and Nanoformulations	17
The Application of the Combination of Monte Carlo Optimization Method based QSAR Modeling and Molecular Docking in Drug Design and Development	17
Marine Sponge-Associated Fungi as Potential Novel Bioactive Natural Product Sources for Drug Discovery: A Review	17
Structure and Activity of Pentacyclic Triterpenes Codrugs. A Review	17
A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies	17
Current Insights into the Chemistry and Antitubercular Potential of Benzimidazole and Imidazole Derivatives	17
Advances in Ethnobotany, Synthetic Phytochemistry and Pharmacology of Endangered Herb Picrorhiza kurroa (Kutki): A Comprehensive Review (2010-2020)	17
Isatin Hybrids and Their Pharmacological Investigations	17
Diversified Synthetic Pathway of 1, 4-Dihydropyridines: A Class of Pharmacologically Important Molecules	17
Herbal Extracts with Antifungal Activity against Candida albicans: A Systematic Review	16
Inhibitors of Cholinesterases in Pharmacology: the Current Trends	16
Emerging Role of Terpenoids for the Treatment of Cancer: A Review	16
Virtual Screening of Natural Products Database	16
Antioxidant Activity of 1,2,4-Triazole and its Derivatives: A Mini-Review	16
Hypericin Ameliorates Maternal Separation-Induced Cognitive Deficits and Hippocampal Inflammation in Rats	16

Association of Micro RNA and Postoperative Cognitive Dysfunction: A Review	16
Recent Progress of Oridonin and Its Derivatives for the Treatment of Acute Myelogenous Leukemia	15
The Chemistry of Triazine Isomers: Structures, Reactions, Synthesis and Applications	15
Macrolactin Antibiotics: Amazing Natural Products	15
1,3,4-Oxadiazole Containing Compounds As Therapeutic Targets For Cancer Therapy	15
Pyridine Moiety: An Insight into Recent Advances in the Treatment of Cancer	15
Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor- Kappa B (NF-kB) Inhibitors	14
Ferroptosis Inhibitors as Potential New Therapeutic Targets for Cardiovascular Disease	14
Moringa Oleifera: A Review of Its Occurrence, Pharmacological Importance and Oxidative Stress	14
Anti-aging Natural Compounds and their Role in the Regulation of Metabolic Pathways Leading to Longevity	14
Pharmacological Efficacy and Safety of Glycyrrhiza glabra in the Treatment of Respiratory Tract Infections	13
Advances on the Anti-Inflammatory Activity of Oleanolic Acid and Derivatives	13
The Role of 3'UTR of RNA Viruses on mRNA Stability and Translation Enhancement	13
A Systematic Review of Current Progresses in the Nucleic Acid-Based Therapies for Neurodegeneration with Implications for Alzheimer’s Disease	13
Irreversible Kinase Inhibitors Targeting Cysteine Residues and their Applications in Cancer Therapy	13
Multitarget Directed Ligand Approaches for Alzheimer’s Disease: A Comprehensive Review	13
Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery	13
GSK-3β and its Inhibitors in Alzheimer's Disease: A Recent Update	13
Medicinally Privileged Sultams: Synthesis and Mechanism of Action	13
Chromenes - A Novel Class of Heterocyclic Compounds: Recent Advancements and Future Directions	13
Cyclopropyl Scaffold: A Generalist for Marketed Drugs	13
Medicinal Potential of Heterocyclic Compounds from Diverse Natural Sources for the Management of Cancer	13
Recent Advances in the Development of Fatty Acid Synthase Inhibitors as Anticancer Agents	12
Synthesis, Cytotoxicity and Molecular Docking Simulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages	12
Glitazones, PPAR-γ and Neuroprotection	12
Carbazole Derivatives as Kinase-Targeting Inhibitors for Cancer Treatment	12
Phytotherapy for Wound Healing: The Most Important Herbal Plants in Wound Healing Based on Iranian Ethnobotanical Documents	12
Adhatoda vasica (Nees.): A Review on its Botany, Traditional uses, Phytochemistry, Pharmacological Activities and Toxicity	12
Novel Mitochondria-targeted Drugs for Cancer Therapy	12
Biological Role of AKT and Regulation of AKT Signaling Pathway by Thymoquinone: Perspectives in Cancer Therapeutics	12
1,8-Naphthyridine Derivatives: A Privileged Scaffold for Versatile Biological Activities	12
p-Benzoquinone as a Privileged Scaffold of Pharmacological Significance: A Review	12
Diverse Thiophenes as Scaffolds in Anti-cancer Drug Development: A Concise Review	12
Anticancer Agents Based on Vulnerable Components in a Signalling Pathway	12
Andrographolide: Synthetic Methods and Biological Activities	12
Design, Synthesis, Molecular Docking Study and Anti-Hepatocellular Carcinoma Evaluation of New Bis-Triazolothiadiazines	11
The Importance of Rhodanine Scaffold in Medicinal Chemistry: A Comprehensive Overview	11
Advances in Research on the Preparation and Biological Activity of Maslinic Acid	11
Quinoxaline: A Chemical Moiety with Spectrum of Interesting Biological Activities	11
Role of Cathepsin B in Cancer Progression: A Potential Target for Coordination Compounds	11
Effective Pharmacophore for CDC25 Phosphatases Enzyme Inhibitors: Newly Synthesized Bromothiazolopyrimidine Derivatives	11
A Review on Classification and Biological Activities of Alkaloids from the Genus Zanthoxylum Species	11
Association of Zinc and Copper Status with Cardiovascular Diseases and their Assessment Methods: A Review Study	11
Thiophene and Its Analogs as Prospective Antioxidant Agents: A Retrospective Study	11
Novel Niacin Receptor Agonists: A Promising Strategy for the Treatment of Dyslipidemia	11
Micro-RNA and the Features of Metabolic Syndrome: A Narrative Review	11
A Review of the Effects of Gold, Silver, Selenium, and Zinc Nanoparticles on Diabetes Mellitus in Murine Models	11
Therapeutic Journey and Recent Advances in the Synthesis of Coumarin Derivatives	11
Research Progress in Alpha-fetoprotein-induced Immunosuppression of Liver Cancer	11
The Zinc-dependent HDACs: Non-histone Substrates and Catalytic Deacylation Beyond Deacetylation	11
Current Perspective of Synthesis of Medicinally Relevant Benzothiazole based Molecules: Potential for Antimicrobial and Anti-Inflammatory Activities	11
Xanthone: Potential Acetylcholinesterase Inhibitor for Alzheimer's Disease Treatment	11
Regulation of Catechins in Uric Acid Metabolism Disorder Related Human Diseases	11
Advances in BPA-induced Oxidative Stress and Related Effects and Mechanisms in Liver, 1991-2017	10
Anticancer Activity of Diosgenin and Its Semi-synthetic Derivatives: Role in Autophagy Mediated Cell Death and Induction of Apoptosis	10
Aquaporins and Roles in Brain Health and Brain Injury	10
Modulation of Calcium Signaling in Glioblastoma Multiforme: A Therapeutic Promise for Natural Products	10
Inhibition of S-protein RBD and hACE2 Interaction for Control of SARSCoV- 2 Infection (COVID-19)	10
Effectiveness of Azithromycin as Add-on Therapy in COVID-19 Management	10
Recent Progress of Bioactivities, Mechanisms of Action, Total Synthesis, Structural Modifications and Structure-activity Relationships of Indole Derivatives: A Review	10
Applications of ROS-InducedZr-MOFs Platform in Multimodal Synergistic Therapy	10
Recent Updates on Free Fatty Acid Receptor 1 (GPR-40) Agonists for the Treatment of Type 2 Diabetes Mellitus	10
A Review on Vitamin E Natural Analogues and on the Design of Synthetic Vitamin E Derivatives as Cytoprotective Agents	10
Astaxanthin and Nrf2 Signaling Pathway: A Novel Target for New Therapeutic Approaches	10
Ultrasmall Europium, Gadolinium, and Dysprosium Oxide Nanoparticles: Polyol Synthesis, Properties, and Biomedical Imaging Applications	10
Advances in Pyrazole Based Scaffold as Cyclin-dependent Kinase 2 Inhibitors for the Treatment of Cancer	10
An Insight in Pathophysiological Mechanism of Alzheimer’s Disease and its Management Using Plant Natural Products	10
Glycyrrhizin as a Potential Treatment for the Novel Coronavirus (COVID-19)	10
Medicinal and Biological Significance of Phenoxazine Derivatives	10
The QSAR Paradigm in Fragment-Based Drug Discovery: From the Virtual Generation of Target Inhibitors to Multi-Scale Modeling	10
The Quinazoline-Chalcone and Quinazolinone-Chalcone Hybrids: A Promising Combination for Biological Activity	10
The Recent Development of Piperazine and Piperidine Derivatives as Antipsychotic Agents	10
The Role of the Cannabinoid System in Opioid Analgesia and Tolerance	10
Development of Natural Bioactive Alkaloids: Anticancer Perspective	10
Design, Synthesis, SAR Study, Antimicrobial and Anticancer Evaluation of Novel 2-Mercaptobenzimidazole Azomethine Derivatives	10
CRISPR-Cas9 Genome Engineering: Trends in Medicine and Health	9
A Review on a Medicinal and Edible Plant: Aralia elata (Miq.) Seem.	9
Appraisal of the Role of In silico Methods in Pyrazole Based Drug Design	9
G-Protein Coupled Receptors Involved in the Resolution of Inflammation: Ligands and Therapeutic Perspectives	9
Plant Polyphenols: Natural and Potent UV-Protective Agents for the Prevention and Treatment of Skin Disorders	9

A Comprehensive Review on Therapeutic Applications of Ferulic Acid and its Novel Analogues: A Brief Literature	9
PROTACs in Treatment of Cancer: A Review	9
Assembly of Benzothiazine and Triazole in a Single Molecular Entity: Synthesis of -Oxicam Derived Novel Molecules as Potential Antibacterial/ Anti-cancer Agents	9
Multi-Target Drug Design of Anti-Alzheimer’s Disease based on Tacrine	9
Natural Terpenoids as Neuroinflammatory Inhibitors in LPS-stimulated BV-2 Microglia	9
Curcumin as a Natural Modulator of B Lymphocytes: Evidence from In Vitro and In Vivo Studies	9
Natural Bioactive New Withanolides	9
Consensus Analyses in Molecular Docking Studies Applied to Medicinal Chemistry	9
Interactions of Dehydrogenase Enzymes with Nanoparticles Industrial and Medical Applications and Challenges: Mini-review	9
Chitosan: Applications in Drug Delivery System	9
Human Galectin-1 in Multiple Cancers: A Privileged Molecular Target in Oncology	9
Brassica oleracea var. capitata f. alba: A Review on its Botany, Traditional uses, Phytochemistry and Pharmacological Activities	9
A Comprehensive Review on Linum usitatissimum Medicinal Plant: Its Phytochemistry, Pharmacology, and Ethnomedicinal Uses	9
Nano-Strategies for Improving the Bioavailability of Inhaled Pharmaceutical Formulations	9
Prognostic Implications of Immunohistochemical Biomarkers in Non-muscle-invasive Blad Cancer and Muscle-invasive Bladder Cancer	8
The Research Progress of DPP-4 Inhibitors	8
Recent Update on the Anti-infective Potential of β-carboline Analogs	8
Bioactivity of Natural Polyphenols as Antiparasitic Agents and their Biochemical Targets	8
A Review: Discovering 1,3,4-oxadiazole and Chalcone Nucleus for Cytotoxicity / EGFR Inhibitory Anticancer Activity	8
Recent Advances in the Development of Macrolide Antibiotics as Antimicrobial Agents	8
Discovery and Development of Antibacterial Agents: Fortuitous and Designed	8
The Potential Application of Novel Drug Delivery Systems for Phytopharmaceuticals and Natural Extracts – Current Status and Future Perspectives	8
Biodegradable Polymers and their Applications: A Review	8
Therapeutic Potential of Resveratrol in the Treatment of Glioma: Insights into its Regulatory Mechanisms	8
Genome-wide Core Proteome Analysis of Brucella melitensis Strains for Potential Drug Target Prediction	8
A Short Review on Glucogallin and its Pharmacological Activities	8
Computational Studies on Acetylcholinesterase Inhibitors: From Biochemistry to Chemistry	8
Mediterranean Diet Polyphenols: Anthocyanins and Their Implications for Health	8
Phytochemical Profiles and their Anti-inflammatory Responses Against Influenza from Traditional Chinese Medicine or Herbs	8
A Review on Rotenoids: Purification, Characterization and its Biological Applications	8
Osthole: Synthesis, Structural Modifications, and Biological Properties	8
Medicinal Chemistry Meets Electrochemistry: Redox Potential in the Role of Endpoint or Molecular Descriptor in QSAR/QSPR	8
Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?	8
An Overview of the Synthetic Route to the Marketed Formulations of Pyrimidine: A Review	8
Biomedical Implications of Plant-based Principles as Antidepressants: Prospects for Novel Drug Development	7
Single Heterocyclic Compounds as Monoamine Oxidase Inhibitors: From Past to Present	7
A Comprehensive Review of Garcinia pedunculata Roxb. and its Therapeutic Potential	7
In Silico Modeling of the α7 Nicotinic Acetylcholine Receptor: New Pharmacological Challenges Associated with Multiple Modes of Signaling	7
Imidazole: Multi-targeted Therapeutic Leads for the Management of Alzheimer’s Disease	7
Selection of Suitable Protein Structure from Protein Data Bank: An Important Step in Structure-based Drug Design Studies	7
Evodiamine: A Privileged Structure with Broad-ranging Biological Activities	7
The Research Progress of Direct Thrombin Inhibitors	7
Advances in Biocatalytic Synthesis, Pharmacological Activities, Pharmaceutical Preparation and Metabolism of Ginsenoside Rh2	7
Recent Developments in Nano-Drug Delivery Systems Loaded by Phytochemicals for Wound Healing	7
Current Biomedical and Diagnostic Applications of Gold Micro and Nanoparticles	7
2-Substituted-mercapto-quinazolin-4(3H)-ones as DHFR Inhibitors	7
Current Progress in Biomedical Applications of Chitosan-Carbon Nanotube Nanocomposites: A Review	7
Novel Derivatives of Nicotinic Acid as Promising Anticancer Agents	7
Drug Re-purposing Approach and Potential Therapeutic Strategies to Treat COVID-19	7
Roles of Cannabidiol in the Treatment and Prevention of Alzheimer’s Disease by Multi-target Actions	7
Hemoglobin F (HbF) Inducers; History, Structure and Efficacies	7
Tanshinones and their Derivatives: Heterocyclic Ring-Fused Diterpenes of Biological Interest	7
Exploring Quinolone Scaffold: Unravelling the Chemistry of Anticancer Drug Design	7
DNA Interaction and Cytotoxic studies on Mono/Di-Oxo and Peroxo- Vanadium (V) complexes - A Review	7
Pharmacological and Therapeutic Aspects of Plants from the Genus Ferula: A Comprehensive Review	7
Discovering the Potentials of Medicinal Mushrooms in Combating Depression – A Review	7
Effects of Green Tea (−)-Epigallocatechin-3-Gallate (EGCG) on Cardiac Function - A Review of the Therapeutic Mechanism and Potentials	7
Cathepsin B-A Neuronal Death Mediator in Alzheimer’s Disease Leading to Neurodegeneration	7
Antiviral Drug Discovery and Development for Mayaro Fever – What do we have so far?	7
Repurposed Antiviral Drugs for the Treatment of COVID-19: Syntheses, Mechanism of Infection and Clinical Trials	7