Biogerontology

Article	Citations
No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging	73
Hypoxia-inducible factor and cellular senescence in pulmonary aging and disease	71
The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cell	45
An AMP Kinase-pathway dependent integrated stress response regulates ageing and longevity	41
The potential use of nanozyme in aging and age‐related diseases	40
Senescence of bone marrow mesenchymal stem cells in Wistar male rats receiving normal chow/high-calorie diets with/without vitamin D	35
GDF-15 as a proxy for epigenetic aging: associations with biological age markers, and physical function	30
Directionality theory and mortality patterns across the primate lineage	29
Association of serum metabolites with frailty phenotype and its components: a cross-sectional case–control study	28
Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach	27
The potential link between the development of Alzheimer’s disease and osteoporosis	26
Harnessing the fundamental roles of vitamins: the potent anti-oxidants in longevity	22
Aging through the lens of mitochondrial DNA mutations and inheritance paradoxes	21
Transcriptional activation of genes associated with the matrisome is a common feature of senescent endothelial cells	21
Beyond balance: the impact of adult sex ratios on reproduction and longevity in Zophobas morio rearing	21
Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies	20
Mitochondria and telomeres: hand in glove	19
Forkhead box P1 transcriptionally activates IGF-1 to lighten ox-LDL-induced endothelial cellular senescence by inactivating NLRP3 inflammasome	19
Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats	19
Level-dependent effects of predation stress on prey development, lifespan and reproduction in mites	18
Immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older residents of a long-term care facility: relation with age, frailty and prior infection status	18
Correlative links between natural radiation and life expectancy in the US population	17
Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders	17
Arnold Mitnitski: mathematician who pioneered a new understanding of frailty (1944 – 2021)	17
Simultaneous activation of the hydrogen sulfide biosynthesis genes (CBS and CSE) induces sex-specific geroprotective effects in Drosophila melanogaster	17

Renal aging and mitochondrial quality control	16
The SGLT2 inhibitor empagliflozin inhibits skeletal muscle fibrosis in naturally aging male mice through the AMPKα/MMP9/TGF-β1/Smad pathway	15
Inflammaging in domestic dogs: basal level concentrations of IL-6, IL-1β, and TNF-α in serum of healthy dogs of different body sizes and ages	15
Age and dietary restriction modulate mitochondrial quality in quadriceps femoris muscle of male mice	15
Cell-type specific and differential expression of LINC-RSAS long noncoding RNA declines in the testes during ageing of the rat	14
Prematurely aging female mice improve their behavioural response, immunity, redox state, and lifespan after a short social interaction with non-prematurely aging mice	14
CeO2 nanoparticles improve prooxidant/antioxidant balance, life quality and survival of old male rats	14
Inhibitory immune checkpoints suppress the surveillance of senescent cells promoting their accumulation with aging and in age-related diseases	14
Long-term sulforaphane-treatment restores redox homeostasis and prevents cognitive decline in middleaged female and male rats, but cannot revert previous damage in old animals	13
Aberrant telomeric structures and serum markers of telomere dysfunction in healthy aging: a preliminary study	13
Mapping sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential?	13
Low-molecular-weight heparin ameliorates intestinal barrier dysfunction in aged male rats via protection of tight junction proteins	13
Correction: Empaglifozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress	13
Melatonin-related signaling pathways and their regulatory effects in aging organisms	12
Alexey Olovnikov: theoretical biology beyond the margins	12
Triglycerides, high-density lipoprotein and cognitive function in middle-aged and older adults: a cross-sectional analysis	12
Long-term detraining reverses the improvement of lifelong exercise on skeletal muscle ferroptosis and inflammation in aging rats: fiber-type dependence of the Keap1/Nrf2 pathway	12
The crosstalk between CNS resident glial cells and peripheral immune cells is critical for age-dependent demyelination and subsequent remyelination	12
Distinguishing the intrinsic and extrinsic causes of changes in human mortality by examining life-table aging rate (LAR) trajectories through the lens of generalized Gompertz-Makeham law	11
Essential amino acids and branched-chain amino acids are associated with skeletal muscle and inflammatory parameters in older age	11
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders	11
Neuroinflammation increases in old and oldest-old rats except for dura mater meningeal tissue with significant gender differences: a translational perspective	11
Redox modulatory role of DJ-1 in Parkinson’s disease	11
Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster	10
T-cell lymphocytes’ aging clock: telomeres, telomerase and aging	10
Age, cancer, and the dual burden of cancer and doxorubicin in skeletal muscle wasting in female rats: which one to blame?	9
Influence of α-lipoic acid on longevity and stress resistance in Drosophila melanogaster fed with a high-fat diet	9
A novel (−)-(2S)-7,4′-dihydroxyflavanone compound for treating age-related diabetes mellitus through immunoinformatics-guided activation of CISD3	9
Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model	9
AcidAGE: a biological age determination neural network based on urine organic acids	9
The effect of three types of water-based training protocols on thymus atrophy and specific indicators of cellular immune senescence in aged male rats	9
Regulatory Roles of Exosomes in Aging and Aging-Related Diseases	9
Dysbiosis and fecal microbiota transplant: Contemplating progress in health, neurodegeneration and longevity	8
Upregulation of LXRβ/ABCA1 pathway alleviates cochlear hair cell senescence of C57BL/6 J mice via reducing lipid droplet accumulation	8
Investigating the aging-modulatory mechanism of Rasayana Churna, an Ayurvedic herbal formulation, using a computational approach	8
Age-related decline in the expression of BRG1, ATM and ATR are partially reversed by dietary restriction in the livers of female mice	8
Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes	8
The protein cargo of extracellular vesicles correlates with the epigenetic aging clock of exercise sensitive DNAmFitAge	7
Correction: Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease	7
A novel rat model of sarcopenic obesity based on aging and high-fat diet consumption	7
Immune genes involved in synaptic plasticity during early postnatal brain development contribute to post-stroke damage in the aging male rat brain	7
Dietary intake of GDF11 delays the onset of several biomarkers of aging in male mice through anti-oxidant system via Smad2/3 pathway	7
Swimming exercise with l-arginine coated nanoparticles supplementation upregulated HAND2 and TBX5 expression in the cardiomyocytes of aging male rats	7
Ribose-induced advanced glycation end products reduce the lifespan in Drosophila melanogaster by changing the redox state and down-regulating the Sirtuin genes	7
Retraction Note to: Carbohydrate-restricted diet promotes skin senescence in senescence-accelerated prone mice	7
Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease	7
RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells	6
Ufuk Çakatay (editor): Redox Signaling and Biomarkers in Ageing	6
Network analysis in aged C. elegans reveals candidate regulatory genes of ageing	6
Application potential of senolytics in clinical treatment	6

Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential skin rejuvenation in male mice	6
Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster	6
Long-term dietary restriction ameliorates ageing-related renal fibrosis in male mice by normalizing mitochondrial functions and autophagy	6
IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway	6
Predation stress experienced as immature mites extends their lifespan	6
High stability of blood parameters during mouse lifespan: sex-specific effects of every-other-day fasting	6
The influence of biological sex in human skeletal muscle transcriptome during ageing	6
Metabolic and physical function are improved with lifelong 15% calorie restriction in aging male mice	6
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration	6
Empagliflozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress	6
2,4-Dinitrophenol is toxic on a low caloric diet but extends lifespan of Drosophila melanogaster on nutrient-rich diets without an impact on metabolism	6
Associations between dietary carotenoid and biological age acceleration: insights from NHANES 2009–2018	6
GDF15/MIC-1: a stress-induced immunosuppressive factor which promotes the aging process	5
Proteostasis networks in aging: novel insights from text-mining approaches	5
Sustained exposure to high glucose induces differential expression of cellular senescence markers in murine macrophages but impairs immunosurveillance response to senescent cells secretome	5
The potential longevity-promoting hypoxic-hypercapnic environment as a measure for radioprotection	5
Geroprotective effects of GdVO4:Eu3 + nanoparticles, metformin and calorie restriction in male rats with accelerated aging induced by overnutrition in early postnatal ontogenesis	5
Rooibos tea—in the cross fire of ROS, mitochondrial dysfunction and loss of proteostasis—positioned for healthy aging	5
The role of phagocytic cells in aging: insights from vertebrate and invertebrate models	5
Roles of genistein in learning and memory during aging and neurological disorders	5
Insights on the role of l-lactate as a signaling molecule in skin aging	5
Linking telomere dynamics to evolution, life history and environmental change: perspectives, predictions and problems	5
Identification of Isthmin1 in the small annual fish, Nothobranchius guentheri, as a novel biomarker of aging and its potential rejuvenation activity	4
Chrysin mitigates neuronal apoptosis and impaired hippocampal neurogenesis in male rats subjected to D-galactose-induced brain aging	4
Aging disrupts the temporal organization of antioxidant defenses in the heart of male rats and phase shifts circadian rhythms of systolic blood pressure	4
Hormesis is an evolutionary expectation: implications for aging	4
The mitochondrial and cytoplasmic superoxide anion imbalance trigger the expression of certain cellular aging markers in HaCaT keratinocytes	4
Age-dependent and modality-specific changes in the phenotypic markers Nav1.8, ASIC3, P2X3 and TRPM8 in male rat primary sensory neurons during healthy aging	4
Piperine improves the health span of Drosophila melanogaster with age- and sex-specific effect	4
“Development of gerontology would be more effective under governmental support”: an interview with Vladimir N. Anisimov	4
Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex	4
Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components	4
COVID-19 detection in CT and CXR images using deep learning models	4
Investigating cognitive impairments and hippocampal proteome alterations in aged male rats with TAA-Induced minimal hepatic encephalopathy	4
The role of genetic/epigenetic factors and microenvironment in hematopoietic stem cell ageing	3
Aging impairs recovery from stress-induced depression in male rats possibly by alteration of microRNA-101 expression and Rac1/RhoA pathway in the prefrontal cortex	3
Marital and living status and biological ageing trajectories: a longitudinal cohort study with a 20-year follow-up	3
Screening the active ingredients of plants via molecular docking technology and evaluating their ability to reduce skin photoaging	3
The interplay of p16INK4a and non-coding RNAs: bridging cellular senescence, aging, and cancer	3
Elucidating the role of peripheral monocyte nicotinic acetylcholine receptors and inflammation in cognitive outcomes in older adults	3
Differential effects of aging on hippocampal ultrastructure in male vs. female rats	3
Pax6 affects Ras-Raf-ERK1/2 in mouse aging brain	3
Common factors among three types of cells aged in mice	3
Plasma therapy: a novel intervention to improve age-induced decline in deudenal cell proliferation in female rat model	3
Editorial note for special issue on ‘dietary interventions for healthy ageing and longevity’	3
Investigating genetic links between biological aging and adverse pregnancy outcomes	3
The potential of flavonoids to mitigate cellular senescence in cardiovascular disease	3
Oxygen transport across the lifespan of male Sprague Dawley rats	3
Production and scavenging of reactive oxygen species both affect reproductive success in male and female Drosophila melanogaster	2
Telomere shortening induces aging-associated phenotypes in hiPSC-derived neurons and astrocytes	2
Estrogen receptor alpha mediates 17β-estradiol, up-regulates autophagy and alleviates hydrogen peroxide-induced vascular senescence	2
Analysis of the relationship between age-related erythrocyte dysfunction and fatigue	2
Correction to: Estrogen receptor alpha mediates 17β-estradiol, up-regulates autophagy and alleviates hydrogen peroxide-induced vascular senescence	2
Coniferaldehyde activates autophagy and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans via par-4/aak-2/skn-1 pathway	2
Intracellular cytokines in peritoneal leukocytes relate to lifespan in aging and long-lived female mice	2
The dichotomic role of cytokines in aging	2
Non-coding RNAs in photoaging-related mechanisms: a new paradigm in skin health	2
Mitochondria-targeted senotherapeutic interventions	2
Measuring healthy ageing: current and future tools	2
The evolution of ageing: classic theories and emerging ideas	2
Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging	2
Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions	2
Enhancing the human health and lifespan: a targeted strategy emphasizing statins	2
Dietary intervention with Tinospora cordifolia improved aging-related decline in locomotor coordination and cerebellar cell survival and plasticity in female rats	2
Invariances in relations between aging, exposure to external hazards, and mortality reflected in life table aging rate (LAR) patterns examined through the lens of generalized Gompertz–Makeham law	2
Age-dependent effect of continuous ‘artificial light at night’ on circadian rhythm in male rats: neuroprotective role of melatonin	2
An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law	2
How soon do metabolic alterations and oxidative distress precede the reduction of muscle mass and strength in Wistar rats in aging process?	2
Revealing the molecular links between coronary heart disease and cognitive impairment: the role of aging-related genes and therapeutic potential of stellate ganglion block	2
Correction to: The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders	2
Correction to: Covid-19 and the next outbreak: decreasing frailty by using mild stress?	2
Disturbances in cell wall biogenesis as a key factor in the replicative aging of budding yeast	1
Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks	1
Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats	1
Associations between lifestyle factors, physiological conditions, and epigenetic age acceleration in an Asian population	1
The opposite aging effect to single cell transcriptome profile among cell subsets	1
Telomeres in health and longevity: special issue in memory of Alexey Olovnikov	1
Isotschimgine promotes lifespan, healthspan and neuroprotection of Caenorhabditis elegans via the activation of nuclear hormone receptors	1
Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function	1
New life expectancy forecasts are too optimistic	1

Neuroinflammaging and the Immune Landscape: The Role of Autophagy and Senescence in Aging Brain	1
Chromosome ends and the theory of marginotomy: implications for reproduction	1
Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology	1
Oxidative stress-induced gene expression changes in prostate epithelial cells in vitro reveal a robust signature of normal prostatic senescence and aging	1
Compensation effect of mortality is a challenge to substantial lifespan extension of humans	1
Nicotinamide mononucleotide suppresses cellular senescence and increases aquaporin 5 expression in the submandibular gland of aged male mice to ameliorate aging-related dry mouth	1
Redox signaling and modulation in ageing	1
A comprehensive model for the biochemistry of ageing, senescence and longevity	1
Signaling mechanisms underlying lymphatic vessel dysfunction in skin aging and possible anti-aging strategies	1
Multi-omics analysis reveals the potential mechanisms underlying long-term exercise-induced enhancement of learning and memory in male mice	1
A CRISPR base editing approach for the functional assessment of telomere biology disorder-related genes in human health and aging	1
Alexander Vaiserman (1957–2021)	1
Harnessing the FOXO-SIRT1 axis: insights into cellular stress, metabolism, and aging	1
Contribution of senescent and reactive astrocytes on central nervous system inflammaging	1
Role of a small GTPase Cdc42 in aging and age-related diseases	1
Responsible biology, aging populations and the 50th anniversary of the “War on Cancer”	1
The impact of mosaic loss of the Y chromosome (mLOY) in men of advanced age	1
Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans	1
Lipids: biomarkers of healthy aging	1
Male sex hormones, aging, and inflammation	1
“Slight chemical damage due to drinking modest amount of sake, might induce beneficial effects” as a form of hormesis: an interview with Professor Sataro Goto	1
The role of NAD and NAD precursors on longevity and lifespan modulation in the budding yeast, Saccharomyces cerevisiae	1
Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases	1
The impact of social partners: investigating mixed-strain housing effects on aging in female mice	1
Fisetin, a potential skin rejuvenation drug that eliminates senescent cells in the dermis	1