Biogerontology

Article	Citations
Arnold Mitnitski: mathematician who pioneered a new understanding of frailty (1944 – 2021)	83
Prematurely aging female mice improve their behavioural response, immunity, redox state, and lifespan after a short social interaction with non-prematurely aging mice	82
Beyond balance: the impact of adult sex ratios on reproduction and longevity in Zophobas morio rearing	47
Forkhead box P1 transcriptionally activates IGF-1 to lighten ox-LDL-induced endothelial cellular senescence by inactivating NLRP3 inflammasome	47
The crosstalk between CNS resident glial cells and peripheral immune cells is critical for age-dependent demyelination and subsequent remyelination	41
Transcriptional activation of genes associated with the matrisome is a common feature of senescent endothelial cells	41
No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging	33
Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies	32
Insights on the role of l-lactate as a signaling molecule in skin aging	28
Proteostasis networks in aging: novel insights from text-mining approaches	28
Swimming exercise with l-arginine coated nanoparticles supplementation upregulated HAND2 and TBX5 expression in the cardiomyocytes of aging male rats	25
Investigating the aging-modulatory mechanism of Rasayana Churna, an Ayurvedic herbal formulation, using a computational approach	24
Immune genes involved in synaptic plasticity during early postnatal brain development contribute to post-stroke damage in the aging male rat brain	23
Empagliflozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress	22
Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components	21
Ufuk Çakatay (editor): Redox Signaling and Biomarkers in Ageing	21
Roles of genistein in learning and memory during aging and neurological disorders	21
Retraction Note to: Carbohydrate-restricted diet promotes skin senescence in senescence-accelerated prone mice	21
Reproduction and preference to macronutrients have different relations to biological or chronological age in Drosophila	20
Long-term dietary restriction ameliorates ageing-related renal fibrosis in male mice by normalizing mitochondrial functions and autophagy	20
Oxygen transport across the lifespan of male Sprague Dawley rats	18
Correction: Immune genes involved in synaptic plasticity during early postnatal brain development contribute to post-stroke damage in the aging male rat brain	18
Intracellular cytokines in peritoneal leukocytes relate to lifespan in aging and long-lived female mice	17
Marital and living status and biological ageing trajectories: a longitudinal cohort study with a 20-year follow-up	17
ATM and p53 in aging and cancer: a double-edged sword in genomic integrity	17

Age-dependent effect of continuous ‘artificial light at night’ on circadian rhythm in male rats: neuroprotective role of melatonin	17
Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions	16
Oxidative stress-induced gene expression changes in prostate epithelial cells in vitro reveal a robust signature of normal prostatic senescence and aging	16
Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects	16
Disturbances in cell wall biogenesis as a key factor in the replicative aging of budding yeast	15
Targeting Wnt signaling pathway by polyphenols: implication for aging and age-related diseases	15
Harnessing the FOXO-SIRT1 axis: insights into cellular stress, metabolism, and aging	15
Consumptıon of ultra-processed foods can accelerate age-related appearance of sarcopenıa	14
Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology	14
Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis	14
An evaluation of aging measures: from biomarkers to clocks	14
Dental pulp and apical papilla cells senescence: causes, consequences, and prevention	13
The nexus between peroxisome abundance and chronological ageing in Saccharomyces cerevisiae	13
Alternate day fasting and time-restricted feeding may confer similar neuroprotective effects during aging in male rats	13
Lipid metabolism and ageing in Caenorhabditis elegans: a complex interplay	13
Aging-related changes in metabolic indicators in female rats and their management with Tinospora cordifolia	13
Day time-restricted feeding shows differential synchronizing effects on age-related changes of serotonin metabolism in SCN and the pineal gland in male Wistar rats	13
Berberis vulgaris L. extract supplementation exerts regulatory effects on the lifespan and healthspan of Drosophila through its antioxidant activity depending on the sex	13
The influence of sex-specific factors on biological transformations and health outcomes in aging processes	13
G protein-coupled receptors that influence lifespan of human and animal models	12
From telomeres and senescence to integrated longevity medicine: redefining the path to extended healthspan	12
Aging adipose tissue, insulin resistance, and type 2 diabetes	12
Histone lysine methyltransferases and their specific methylation marks show significant changes in mouse testes from young to older ages	12
Quercetin preserves mitochondria-endoplasmic reticulum contact sites improving mitochondrial dynamics in aged myocardial cells	12
Zbp1 gene: a modulator of multiple aging hallmarks as potential therapeutic target for age-related diseases	12
Chrysin alleviates the impeded neurogenesis in accelerated brain aging by D-galactose in rats	11
Biomarkers of oxidative stress in the post-embryonic characterization of the neotropical annual killifish	11
Dauer larva-derived extracellular vesicles extend the life of Caenorhabditis elegans	11
Calorie-restriction treatment mitigates the aging in rat liver model	11
Beneficial death: A substantial element of evolution?	11
The role of different physical exercises as an anti-aging factor in different stem cells	11
Decoding the impact of ageing and environment stressors on skin cell communication	11
Correction: Directionality theory and mortality patterns across the primate lineage	11
Sex differences in middle-aged and old Wistar rats in response to long-term sulforaphane treatment for prevention of neuroinflammation, cognitive decline and brain senescence	10
Cell-type specific and differential expression of LINC-RSAS long noncoding RNA declines in the testes during ageing of the rat	9
Age-related differences in response to plasma exchange in male rat liver tissues: insights from histopathological and machine-learning assisted spectrochemical analyses	9
Green tea EGCG effectively alleviates experimental colitis in middle-aged male mice by attenuating multiple aspects of oxi-inflammatory stress and cell cycle deregulation	9
Aberrant telomeric structures and serum markers of telomere dysfunction in healthy aging: a preliminary study	9
The age-dependent impacts of treadmill exercise on cognitive impairments by reducing inflammation and oxidative stress in the hippocampus of morphine-exposed rats: the role of SIRTs 3 &4 and BDNF	9
Mapping sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential?	8
High stability of blood parameters during mouse lifespan: sex-specific effects of every-other-day fasting	8
Lifestyle, environment and other major determinants of frailty in older adults: a population-based study from the UK Biobank	8
Directionality theory and mortality patterns across the primate lineage	8
Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach	8
Inhibitory immune checkpoints suppress the surveillance of senescent cells promoting their accumulation with aging and in age-related diseases	8
Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex	8
The potential link between the development of Alzheimer’s disease and osteoporosis	8
Mitochondria and telomeres: hand in glove	8
Harnessing the fundamental roles of vitamins: the potent anti-oxidants in longevity	8
Sustained exposure to high glucose induces differential expression of cellular senescence markers in murine macrophages but impairs immunosurveillance response to senescent cells secretome	8

Association of serum metabolites with frailty phenotype and its components: a cross-sectional case–control study	8
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration	7
The age-dependent neuroglial interaction with peripheral immune cells in coronavirus-induced neuroinflammation with a special emphasis on COVID-19	7
T-cell lymphocytes’ aging clock: telomeres, telomerase and aging	7
Distinguishing the intrinsic and extrinsic causes of changes in human mortality by examining life-table aging rate (LAR) trajectories through the lens of generalized Gompertz-Makeham law	7
Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential skin rejuvenation in male mice	7
Enhancing the human health and lifespan: a targeted strategy emphasizing statins	7
Correction: Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease	7
Chrysin mitigates neuronal apoptosis and impaired hippocampal neurogenesis in male rats subjected to D-galactose-induced brain aging	7
COVID-19 detection in CT and CXR images using deep learning models	7
Alexander Vaiserman (1957–2021)	7
The potential of flavonoids to mitigate cellular senescence in cardiovascular disease	6
Analyzing different aging theories in the context of the brain: DNA damage, inflammation, redox imbalance, and neurodevelopment intertwine	6
Restricting the level of the proteins essential for the regulation of the initiation step of replication extends the chronological lifespan and reproductive potential in budding yeast	6
Isotschimgine promotes lifespan, healthspan and neuroprotection of Caenorhabditis elegans via the activation of nuclear hormone receptors	6
Effects of aging and resistance exercise on muscle strength, physiological properties, longevity proteins, and telomere length in SAMP8 mice	6
Telomeres and telomerase: active but complex players in life-history decisions	6
Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases	6
Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging	6
Investigating genetic links between biological aging and adverse pregnancy outcomes	6
Tissue stretching is a confounding factor for the evaluation of neurodegeneration in the fast-ageing killifish	5
The long noncoding RNA (LINC-RBE) expression in testicular cells is associated with aging of the rat	5
Mitotherapy restores hippocampal mitochondrial function and cognitive impairment in aged male rats subjected to chronic mild stress	5
Use of a novel technique to assess impact of age-related denervation on mouse soleus muscle function	5
Seven knowledge gaps in modern biogerontology	5
Sarcopenia versus cancer cachexia: the muscle wasting continuum in healthy and diseased aging	5
High-quality dietary protein (essential amino acids matched to reproductive needs) partially breaks the lifespan and reproduction trade-off in lubber grasshoppers	5
CHIP and aging: a key regulator of proteostasis and cellular senescence	5
Alterations in bone metabolites with age in C57BL/6 mice model	5
Contribution of senescent and reactive astrocytes on central nervous system inflammaging	5
Geroscience: just another name or is there more to it?	5
Changing dynamics in daily rhythms of oxidative stress indicators in SCN and extra-SCN brain regions with aging in male Wistar rats	5
Dynamics of redox signaling in aging via autophagy, inflammation, and senescence	5
Nicotinamide mononucleotide suppresses cellular senescence and increases aquaporin 5 expression in the submandibular gland of aged male mice to ameliorate aging-related dry mouth	5
Exploring TGF-β signaling in benign prostatic hyperplasia: from cellular senescence to fibrosis and therapeutic implications	4
Daily ingestion of Akkermansia mucciniphila for one month promotes healthy aging and increases lifespan in old female mice	4
The potential use of nanozyme in aging and age‐related diseases	4
Redox modulatory role of DJ-1 in Parkinson’s disease	4
Low-molecular-weight heparin ameliorates intestinal barrier dysfunction in aged male rats via protection of tight junction proteins	4
Heat-induced hormesis in longevity is linked to heat-stress sensitivity across laboratory populations from diverse altitude of origin in Drosophila buzzatii	4
Exploring new markers for biological aging from bioimpedance analysis and cognitive functions in older adults	4
The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cell	4
The SGLT2 inhibitor empagliflozin inhibits skeletal muscle fibrosis in naturally aging male mice through the AMPKα/MMP9/TGF-β1/Smad pathway	4
Ribose-induced advanced glycation end products reduce the lifespan in Drosophila melanogaster by changing the redox state and down-regulating the Sirtuin genes	4
Plasma proteins as potential biomarkers of aging of single tissue and cell type	4
Chronic trans fatty acid consumption shortens lifespan in male Drosophila melanogaster on a high-sugar and high-fat diet	4
Mitochondria: fundamental characteristics, challenges, and impact on aging	4
Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders	4
Age-related decline in the expression of BRG1, ATM and ATR are partially reversed by dietary restriction in the livers of female mice	4
The mitochondrial and cytoplasmic superoxide anion imbalance trigger the expression of certain cellular aging markers in HaCaT keratinocytes	3
The role of genetic/epigenetic factors and microenvironment in hematopoietic stem cell ageing	3
Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease	3
How soon do metabolic alterations and oxidative distress precede the reduction of muscle mass and strength in Wistar rats in aging process?	3
Differential effects of aging on hippocampal ultrastructure in male vs. female rats	3
Application potential of senolytics in clinical treatment	3
Metabolic and physical function are improved with lifelong 15% calorie restriction in aging male mice	3
Telomeres in health and longevity: special issue in memory of Alexey Olovnikov	3
Environmental enrichment: a neurostimulatory approach to aging and ischemic stroke recovery and rehabilitation	3
The potential longevity-promoting hypoxic-hypercapnic environment as a measure for radioprotection	3
The protein cargo of extracellular vesicles correlates with the epigenetic aging clock of exercise sensitive DNAmFitAge	3
Estrogen receptor alpha mediates 17β-estradiol, up-regulates autophagy and alleviates hydrogen peroxide-induced vascular senescence	3
Invariances in relations between aging, exposure to external hazards, and mortality reflected in life table aging rate (LAR) patterns examined through the lens of generalized Gompertz–Makeham law	3
Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans	2
Circulating immune cells in cerebral small vessel disease: a systematic review	2
Measuring healthy ageing: current and future tools	2
“Slight chemical damage due to drinking modest amount of sake, might induce beneficial effects” as a form of hormesis: an interview with Professor Sataro Goto	2
Yeast YPK9 deficiency results in shortened replicative lifespan and sensitivity to hydrogen peroxide	2
Dietary interventions and molecular mechanisms for healthy musculoskeletal aging	2
Lack of age-related respiratory changes in Daphnia	2
A collective analysis of lifespan-extending compounds in diverse model organisms, and of species whose lifespan can be extended the most by the application of compounds	2
Chromosome ends and the theory of marginotomy: implications for reproduction	2
Blood-based biomarkers in centenarians and non-centenarians: a matched, population-based retrospective cohort study using primary care records in Catalonia, Spain	2
Coniferaldehyde activates autophagy and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans via par-4/aak-2/skn-1 pathway	2
Responsible biology, aging populations and the 50th anniversary of the “War on Cancer”	2
Aging-accelerated differential production and aggregation of STAT3 protein in neuronal cells and neural stem cells in the male mouse spinal cord	2
The effects of estrogen depletion in female rats: differential influences on somato-motor and sensory cortices	2
Hormetic association between perceived stress and human epigenetic aging based on resilience capacity	2
Hypertension and cellular senescence	2
Analyzing the causal role of blood cells in aging: a Mendelian randomization study	2
Immunoinformatic-based drug design utilizing hesperetin to target CISD2 activation for liver aging in humans	2

The dichotomic role of cytokines in aging	2
Telomeres and aging: on and off the planet!	2
Lipofuscin, amyloids, and lipid peroxidation as potential markers of aging in Daphnia	2
Aging and short-term calorie restriction differently affect the cardiac and skeletal muscle expression of genes regulating energy substrate utilization in male rats	2
Biochemical, structural and physical changes in aging human skin, and their relationship	2
Delayed cutaneous wound healing in young and old female mice is associated with differential growth factor release but not inflammatory cytokine secretion	2
Essential amino acids and branched-chain amino acids are associated with skeletal muscle and inflammatory parameters in older age	1
Altered lactate/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats	1
Molecular mechanism of caloric restriction mimetics-mediated neuroprotection of age-related neurodegenerative diseases: an emerging therapeutic approach	1
A comprehensive model for the biochemistry of ageing, senescence and longevity	1
The evolution of ageing: classic theories and emerging ideas	1
An AMP Kinase-pathway dependent integrated stress response regulates ageing and longevity	1
2,4-Dinitrophenol is toxic on a low caloric diet but extends lifespan of Drosophila melanogaster on nutrient-rich diets without an impact on metabolism	1
Long-term sulforaphane-treatment restores redox homeostasis and prevents cognitive decline in middleaged female and male rats, but cannot revert previous damage in old animals	1
Alexey Olovnikov: theoretical biology beyond the margins	1
Targeting the epigenetically older individuals for geroprotective trials: the use of DNA methylation clocks	1
Correction: Empaglifozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress	1
Telomeres in skin aging	1
The impact of mosaic loss of the Y chromosome (mLOY) in men of advanced age	1
Melatonin-related signaling pathways and their regulatory effects in aging organisms	1
Brown adipose tissue: a potential target for aging interventions and healthy longevity	1
Maternal malnutrition induces inflammatory pathways and oxidative stress in the dorsolateral prostate of male offspring rats	1
Dietary nitrate maintains intestinal epithelia homeostasis in aged mice	1
Inhibition of mTOR prevents glucotoxicity-mediated increase of SA-beta-gal, p16INK4a, and insulin hypersecretion, without restoring electrical features of mouse pancreatic islets	1
The role of phagocytic cells in aging: insights from vertebrate and invertebrate models	1
GDF15/MIC-1: a stress-induced immunosuppressive factor which promotes the aging process	1
Inflammaging in domestic dogs: basal level concentrations of IL-6, IL-1β, and TNF-α in serum of healthy dogs of different body sizes and ages	1
Male sex hormones, aging, and inflammation	1
Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats	1
Alterations in hippocampal mitochondrial dynamics are associated with neurodegeneration and recognition memory decline in old male mice	1
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway	1
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders	1
Spermidine toxicity in Saccharomyces cerevisiae due to mitochondrial complex III deficiency	1
Correction to: Estrogen receptor alpha mediates 17β-estradiol, up-regulates autophagy and alleviates hydrogen peroxide-induced vascular senescence	1
Dietary intervention with Tinospora cordifolia improved aging-related decline in locomotor coordination and cerebellar cell survival and plasticity in female rats	1
The opposite aging effect to single cell transcriptome profile among cell subsets	1
Linking telomere dynamics to evolution, life history and environmental change: perspectives, predictions and problems	1
Associations between dietary carotenoid and biological age acceleration: insights from NHANES 2009–2018	1
Hormesis is an evolutionary expectation: implications for aging	1
A novel rat model of sarcopenic obesity based on aging and high-fat diet consumption	1
CeO2 nanoparticles improve prooxidant/antioxidant balance, life quality and survival of old male rats	1
An essay on the nominal vs. real definitions of aging	1
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies	1