OOIR: Observatory of International Research

Papers

(The TQCC of Biogerontology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging	73
Hypoxia-inducible factor and cellular senescence in pulmonary aging and disease	71
The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cell	45
An AMP Kinase-pathway dependent integrated stress response regulates ageing and longevity	41
The potential use of nanozyme in aging and age‐related diseases	40
Senescence of bone marrow mesenchymal stem cells in Wistar male rats receiving normal chow/high-calorie diets with/without vitamin D	35
GDF-15 as a proxy for epigenetic aging: associations with biological age markers, and physical function	30
Directionality theory and mortality patterns across the primate lineage	29
Association of serum metabolites with frailty phenotype and its components: a cross-sectional case–control study	28
Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach	27
The potential link between the development of Alzheimer’s disease and osteoporosis	26
Harnessing the fundamental roles of vitamins: the potent anti-oxidants in longevity	22
Transcriptional activation of genes associated with the matrisome is a common feature of senescent endothelial cells	21
Beyond balance: the impact of adult sex ratios on reproduction and longevity in Zophobas morio rearing	21
Aging through the lens of mitochondrial DNA mutations and inheritance paradoxes	21
Gut microbiota influence frailty syndrome in older adults: mechanisms and therapeutic strategies	20
Forkhead box P1 transcriptionally activates IGF-1 to lighten ox-LDL-induced endothelial cellular senescence by inactivating NLRP3 inflammasome	19
Whole-body vibration elicits 40 Hz cortical gamma oscillations and ameliorates age-related cognitive impairment through hippocampal astrocyte synapses in male rats	19
Mitochondria and telomeres: hand in glove	19
Immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in older residents of a long-term care facility: relation with age, frailty and prior infection status	18
Level-dependent effects of predation stress on prey development, lifespan and reproduction in mites	18
Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders	17
Arnold Mitnitski: mathematician who pioneered a new understanding of frailty (1944 – 2021)	17
Simultaneous activation of the hydrogen sulfide biosynthesis genes (CBS and CSE) induces sex-specific geroprotective effects in Drosophila melanogaster	17
Correlative links between natural radiation and life expectancy in the US population	17

Renal aging and mitochondrial quality control	16
Age and dietary restriction modulate mitochondrial quality in quadriceps femoris muscle of male mice	15
The SGLT2 inhibitor empagliflozin inhibits skeletal muscle fibrosis in naturally aging male mice through the AMPKα/MMP9/TGF-β1/Smad pathway	15
Inflammaging in domestic dogs: basal level concentrations of IL-6, IL-1β, and TNF-α in serum of healthy dogs of different body sizes and ages	15
CeO2 nanoparticles improve prooxidant/antioxidant balance, life quality and survival of old male rats	14
Inhibitory immune checkpoints suppress the surveillance of senescent cells promoting their accumulation with aging and in age-related diseases	14
Cell-type specific and differential expression of LINC-RSAS long noncoding RNA declines in the testes during ageing of the rat	14
Prematurely aging female mice improve their behavioural response, immunity, redox state, and lifespan after a short social interaction with non-prematurely aging mice	14
Low-molecular-weight heparin ameliorates intestinal barrier dysfunction in aged male rats via protection of tight junction proteins	13
Correction: Empaglifozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress	13
Long-term sulforaphane-treatment restores redox homeostasis and prevents cognitive decline in middleaged female and male rats, but cannot revert previous damage in old animals	13
Aberrant telomeric structures and serum markers of telomere dysfunction in healthy aging: a preliminary study	13
Mapping sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential?	13
Triglycerides, high-density lipoprotein and cognitive function in middle-aged and older adults: a cross-sectional analysis	12
Long-term detraining reverses the improvement of lifelong exercise on skeletal muscle ferroptosis and inflammation in aging rats: fiber-type dependence of the Keap1/Nrf2 pathway	12
The crosstalk between CNS resident glial cells and peripheral immune cells is critical for age-dependent demyelination and subsequent remyelination	12
Melatonin-related signaling pathways and their regulatory effects in aging organisms	12
Alexey Olovnikov: theoretical biology beyond the margins	12
Essential amino acids and branched-chain amino acids are associated with skeletal muscle and inflammatory parameters in older age	11
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders	11
Neuroinflammation increases in old and oldest-old rats except for dura mater meningeal tissue with significant gender differences: a translational perspective	11
Redox modulatory role of DJ-1 in Parkinson’s disease	11
Distinguishing the intrinsic and extrinsic causes of changes in human mortality by examining life-table aging rate (LAR) trajectories through the lens of generalized Gompertz-Makeham law	11
T-cell lymphocytes’ aging clock: telomeres, telomerase and aging	10
Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster	10
A novel (−)-(2S)-7,4′-dihydroxyflavanone compound for treating age-related diabetes mellitus through immunoinformatics-guided activation of CISD3	9
Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model	9
AcidAGE: a biological age determination neural network based on urine organic acids	9
The effect of three types of water-based training protocols on thymus atrophy and specific indicators of cellular immune senescence in aged male rats	9
Regulatory Roles of Exosomes in Aging and Aging-Related Diseases	9
Age, cancer, and the dual burden of cancer and doxorubicin in skeletal muscle wasting in female rats: which one to blame?	9
Influence of α-lipoic acid on longevity and stress resistance in Drosophila melanogaster fed with a high-fat diet	9
Age-related decline in the expression of BRG1, ATM and ATR are partially reversed by dietary restriction in the livers of female mice	8
Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes	8
Dysbiosis and fecal microbiota transplant: Contemplating progress in health, neurodegeneration and longevity	8
Upregulation of LXRβ/ABCA1 pathway alleviates cochlear hair cell senescence of C57BL/6 J mice via reducing lipid droplet accumulation	8
Investigating the aging-modulatory mechanism of Rasayana Churna, an Ayurvedic herbal formulation, using a computational approach	8
Swimming exercise with l-arginine coated nanoparticles supplementation upregulated HAND2 and TBX5 expression in the cardiomyocytes of aging male rats	7
Ribose-induced advanced glycation end products reduce the lifespan in Drosophila melanogaster by changing the redox state and down-regulating the Sirtuin genes	7
Retraction Note to: Carbohydrate-restricted diet promotes skin senescence in senescence-accelerated prone mice	7
Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease	7
The protein cargo of extracellular vesicles correlates with the epigenetic aging clock of exercise sensitive DNAmFitAge	7
Correction: Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease	7
A novel rat model of sarcopenic obesity based on aging and high-fat diet consumption	7
Immune genes involved in synaptic plasticity during early postnatal brain development contribute to post-stroke damage in the aging male rat brain	7
Dietary intake of GDF11 delays the onset of several biomarkers of aging in male mice through anti-oxidant system via Smad2/3 pathway	7
Long-term dietary restriction ameliorates ageing-related renal fibrosis in male mice by normalizing mitochondrial functions and autophagy	6
IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway	6
Predation stress experienced as immature mites extends their lifespan	6
High stability of blood parameters during mouse lifespan: sex-specific effects of every-other-day fasting	6

The influence of biological sex in human skeletal muscle transcriptome during ageing	6
Metabolic and physical function are improved with lifelong 15% calorie restriction in aging male mice	6
AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration	6
Empagliflozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress	6
2,4-Dinitrophenol is toxic on a low caloric diet but extends lifespan of Drosophila melanogaster on nutrient-rich diets without an impact on metabolism	6
Associations between dietary carotenoid and biological age acceleration: insights from NHANES 2009–2018	6
RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells	6
Ufuk Çakatay (editor): Redox Signaling and Biomarkers in Ageing	6
Network analysis in aged C. elegans reveals candidate regulatory genes of ageing	6
Application potential of senolytics in clinical treatment	6
Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential skin rejuvenation in male mice	6
Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster	6