Molecules

Article	Citations
Comprehensive Review on Alzheimer’s Disease: Causes and Treatment	989
Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology	684
An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation	600
Important Flavonoids and Their Role as a Therapeutic Agent	502
Controlled Drug Delivery Systems: Current Status and Future Directions	427
Therapeutic Nanoparticles and Their Targeted Delivery Applications	424
Plant Flavonoids: Chemical Characteristics and Biological Activity	391
A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives	343
Anthocyanins: A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases	340
Coriandrum sativum L.: A Review on Ethnopharmacology, Phytochemistry, and Cardiovascular Benefits	327
General Health Benefits and Pharmacological Activities of Triticum aestivum L.	310
Industrial Applications of Ionic Liquids	287
COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far	278
Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects	266
Chitosan: A Natural Biopolymer with a Wide and Varied Range of Applications	257
Essential Oils as Natural Sources of Fragrance Compounds for Cosmetics and Cosmeceuticals	257
Anti-Inflammatory Action and Mechanisms of Resveratrol	248
Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review	243
Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments	233
Determination of Antioxidants by DPPH Radical Scavenging Activity and Quantitative Phytochemical Analysis of Ficus religiosa	226
Recent Trends in Controlling the Enzymatic Browning of Fruit and Vegetable Products	226
New Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives	213
Antimicrobial Peptides as Anticancer Agents: Functional Properties and Biological Activities	206
Synthesis and Biological Application of Polylactic Acid	203
Applications and Limitations of Dendrimers in Biomedicine	203

Flavonoids as Potential Anti-Inflammatory Molecules: A Review	201
Recent Advances in Supercritical Fluid Extraction of Natural Bioactive Compounds from Natural Plant Materials	196
Antibody–Drug Conjugates for Cancer Therapy	196
A Global Review on Short Peptides: Frontiers and Perspectives	195
Near-Infrared Spectroscopy in Bio-Applications	194
Autofluorescence in Plants	189
Thymol and Thyme Essential Oil—New Insights into Selected Therapeutic Applications	188
Machine Learning Methods in Drug Discovery	185
A Brief History of Colour, the Environmental Impact of Synthetic Dyes and Removal by Using Laccases	185
Fatty Acid Synthase: An Emerging Target in Cancer	182
Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing	179
The Effects of Flavonoids in Cardiovascular Diseases	178
Hyaluronic Acid and Controlled Release: A Review	173
The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients	173
Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer	172
The Role of Vitamin C, Vitamin D, and Selenium in Immune System against COVID-19	171
Chemical Vapour Deposition of Graphene—Synthesis, Characterisation, and Applications: A Review	166
Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies	165
The Potential of Selected Agri-Food Loss and Waste to Contribute to a Circular Economy: Applications in the Food, Cosmetic and Pharmaceutical Industries	162
Recent Developments in Chitosan-Based Adsorbents for the Removal of Pollutants from Aqueous Environments	161
Adsorption of Crystal Violet Dye Using Activated Carbon of Lemon Wood and Activated Carbon/Fe3O4 Magnetic Nanocomposite from Aqueous Solutions: A Kinetic, Equilibrium and Thermodynamic Study	160
An Insight into FDA Approved Antibody-Drug Conjugates for Cancer Therapy	159
Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance	159
Antibacterial, Antifungal, Antimycotoxigenic, and Antioxidant Activities of Essential Oils: An Updated Review	158
Kissinger Method in Kinetics of Materials: Things to Beware and Be Aware of	156
Anthocyanin Pigments: Beyond Aesthetics	155
Hydrogels: Properties and Applications in Biomedicine	155
Heavy Metals and Human Health: Possible Exposure Pathways and the Competition for Protein Binding Sites	154
Nanotechnology: A Revolution in Modern Industry	154
A Brief Overview on Antioxidant Activity Determination of Silver Nanoparticles	153
A Compressive Review about Taxol®: History and Future Challenges	153
Plants as Sources of Anti-Inflammatory Agents	149
Green Silver and Gold Nanoparticles: Biological Synthesis Approaches and Potentials for Biomedical Applications	149
Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches	148
Nanotechnology in Wastewater Management: A New Paradigm Towards Wastewater Treatment	146
Nanoencapsulation of Promising Bioactive Compounds to Improve Their Absorption, Stability, Functionality and the Appearance of the Final Food Products	146
Modern Approaches in the Discovery and Development of Plant-Based Natural Products and Their Analogues as Potential Therapeutic Agents	144
Factors Affecting Synthetic Dye Adsorption; Desorption Studies: A Review of Results from the Last Five Years (2017–2021)	143
Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy	142
The Protective Role of Butyrate against Obesity and Obesity-Related Diseases	141
Antimicrobial Properties of Chitosan and Chitosan Derivatives in the Treatment of Enteric Infections	140
Role of Cholinergic Signaling in Alzheimer’s Disease	139
Microalgae-Derived Pigments: A 10-Year Bibliometric Review and Industry and Market Trend Analysis	138
Resistance of Gram-Positive Bacteria to Current Antibacterial Agents and Overcoming Approaches	138
Wearable Biosensors: An Alternative and Practical Approach in Healthcare and Disease Monitoring	138
Virtual Screening of Natural Products against Type II Transmembrane Serine Protease (TMPRSS2), the Priming Agent of Coronavirus 2 (SARS-CoV-2)	137
Formulation of More Efficacious Curcumin Delivery Systems Using Colloid Science: Enhanced Solubility, Stability, and Bioavailability	135
Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis	135
Impact of Cross-Coupling Reactions in Drug Discovery and Development	134
Wine Polyphenol Content and Its Influence on Wine Quality and Properties: A Review	133

Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms	133
Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery	133
A Review on Natural Fiber Bio-Composites, Surface Modifications and Applications	133
Chitosan Nanoparticles-Insight into Properties, Functionalization and Applications in Drug Delivery and Theranostics	132
Bioethanol Production by Enzymatic Hydrolysis from Different Lignocellulosic Sources	132
Plant Secondary Metabolites Produced in Response to Abiotic Stresses Has Potential Application in Pharmaceutical Product Development	132
Characteristics of the Proteolytic Enzymes Produced by Lactic Acid Bacteria	131
Health Benefits and Chemical Composition of Matcha Green Tea: A Review	131
Skin Wound Healing: Normal Macrophage Function and Macrophage Dysfunction in Diabetic Wounds	131
Nanomaterials for Wound Dressings: An Up-to-Date Overview	130
Chemical Structure and Biological Activity of Humic Substances Define Their Role as Plant Growth Promoters	127
Industrial Hemp (Cannabis sativa subsp. sativa) as an Emerging Source for Value-Added Functional Food Ingredients and Nutraceuticals	126
Recent Achievements in Dyes Removal Focused on Advanced Oxidation Processes Integrated with Biological Methods	126
Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity	125
Discovery, Development, and Patent Trends on Molnupiravir: A Prospective Oral Treatment for COVID-19	125
Antimicrobial Activity of Quercetin: An Approach to Its Mechanistic Principle	124
Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method	123
Role of Lipid-Based and Polymer-Based Non-Viral Vectors in Nucleic Acid Delivery for Next-Generation Gene Therapy	123
Thiazole Ring—A Biologically Active Scaffold	121
Cultivation of Mushrooms and Their Lignocellulolytic Enzyme Production Through the Utilization of Agro-Industrial Waste	120
Tannins in Food: Insights into the Molecular Perception of Astringency and Bitter Taste	120
Astaxanthin for the Food Industry	120
Fruit and Vegetable Peels: Utilization of High Value Horticultural Waste in Novel Industrial Applications	118
TiO2 as a Photocatalyst for Water Splitting—An Experimental and Theoretical Review	116
Selenium Biofortification: Roles, Mechanisms, Responses and Prospects	116
The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases	115
Role of Monoamine Oxidase Activity in Alzheimer’s Disease: An Insight into the Therapeutic Potential of Inhibitors	115
Effect of Dataset Size and Train/Test Split Ratios in QSAR/QSPR Multiclass Classification	113
Biological Properties and Applications of Betalains	113
Antibacterial Effects of Flavonoids and Their Structure-Activity Relationship Study: A Comparative Interpretation	113
G-Quadruplexes at Telomeres: Friend or Foe?	112
Role of Gut Microbiota, Probiotics and Prebiotics in the Cardiovascular Diseases	112
A Critical Review on Pulsed Electric Field: A Novel Technology for the Extraction of Phytoconstituents	112
Potential of Flavonoid-Inspired Phytomedicines against COVID-19	111
Antioxidant Activity of Selected Phenolic Acids–Ferric Reducing Antioxidant Power Assay and QSAR Analysis of the Structural Features	110
Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms	110
pH-Sensitive Biomaterials for Drug Delivery	109
Plant-Derived Pesticides as an Alternative to Pest Management and Sustainable Agricultural Production: Prospects, Applications and Challenges	109
Antibacterial Activity and Mechanism of Ginger Essential Oil against Escherichia coli and Staphylococcus aureus	108
Bioactive Polysaccharides from Seaweeds	108
Excited-State Intramolecular Proton Transfer: A Short Introductory Review	107
Food-Grade Pickering Emulsions: Preparation, Stabilization and Applications	107
Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells	107
Diversity in Chemical Structures and Biological Properties of Plant Alkaloids	107
Role of Lipids in Food Flavor Generation	107
Spray Drying for the Encapsulation of Oils—A Review	107
Subcritical Water Extraction of Natural Products	106
Mechanistic Insight into Oxidative Stress-Triggered Signaling Pathways and Type 2 Diabetes	106
Dietary Plant Polyphenols: Effects of Food Processing on Their Content and Bioavailability	106
Lipid and Polymer-Based Nanoparticle siRNA Delivery Systems for Cancer Therapy	105
Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals	105
Use of Ionic Liquids and Deep Eutectic Solvents in Polysaccharides Dissolution and Extraction Processes towards Sustainable Biomass Valorization	104
Health Benefits of Quercetin in Age-Related Diseases	104
Recent Advances in the Production and Applications of Ellagic Acid and Its Derivatives. A Review	103
Antiviral Effects of Plant-Derived Essential Oils and Their Components: An Updated Review	103
Nanocellulose Production: Exploring the Enzymatic Route and Residues of Pulp and Paper Industry	103
Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions	102
Alkaloids Used as Medicines: Structural Phytochemistry Meets Biodiversity—An Update and Forward Look	102
Merging Ligand-Based and Structure-Based Methods in Drug Discovery: An Overview of Combined Virtual Screening Approaches	101
Biodegradation Behavior of Poly(Butylene Adipate-Co-Terephthalate) (PBAT), Poly(Lactic Acid) (PLA), and Their Blend in Freshwater with Sediment	101
Berberine as a Potential Anticancer Agent: A Comprehensive Review	101
Natural-Based Hydrogels for Tissue Engineering Applications	100
Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential	100
Health Benefits of Plant-Derived Sulfur Compounds, Glucosinolates, and Organosulfur Compounds	99
Compensate for or Minimize Matrix Effects? Strategies for Overcoming Matrix Effects in Liquid Chromatography-Mass Spectrometry Technique: A Tutorial Review	99
Evaluation of Peptide/Protein Self-Assembly and Aggregation by Spectroscopic Methods	98
Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products	97
Antibody–Drug Conjugates—A Tutorial Review	97
Lignans of Sesame (Sesamum indicum L.): A Comprehensive Review	96
Dietary Flavonoids: Cardioprotective Potential with Antioxidant Effects and Their Pharmacokinetic, Toxicological and Therapeutic Concerns	96
Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy	96
Current Evidence on the Bioavailability of Food Bioactive Peptides	96
Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review	95
Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities	95
Application Research of Biochar for the Remediation of Soil Heavy Metals Contamination: A Review	95
Peptide Therapeutics 2.0	94
Clove Essential Oil (Syzygium aromaticum L. Myrtaceae): Extraction, Chemical Composition, Food Applications, and Essential Bioactivity for Human Health	94
The Utilization of Algae and Seaweed Biomass for Bioremediation of Heavy Metal-Contaminated Wastewater	94
Current Status of Matrix-Assisted Laser Desorption/Ionization–Time-of-Flight Mass Spectrometry (MALDI-TOF MS) in Clinical Diagnostic Microbiology	93
Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols	92

Progresses in Food Packaging, Food Quality, and Safety—Controlled-Release Antioxidant and/or Antimicrobial Packaging	91
Past, Present and Future Perspectives on Halloysite Clay Minerals	91
Application of Ionic Liquids in Electrochemistry—Recent Advances	90
Green and Sustainable Valorization of Bioactive Phenolic Compounds from Pinus By-Products	89
Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health	89
Okra (Abelmoschus Esculentus) as a Potential Dietary Medicine with Nutraceutical Importance for Sustainable Health Applications	89
Natural Compounds for Wood Protection against Fungi—A Review	88
The Pharmaceutical Industry in 2020. An Analysis of FDA Drug Approvals from the Perspective of Molecules	88
Recent Advances in The Polymer Dispersed Liquid Crystal Composite and Its Applications	88
Different Schiff Bases—Structure, Importance and Classification	88
Neuroinflammatory Markers: Key Indicators in the Pathology of Neurodegenerative Diseases	87
Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance	87
The Cannabis Terpenes	86
Processing Factors Affecting the Phytochemical and Nutritional Properties of Pomegranate (Punica granatum L.) Peel Waste: A Review	86
Soluble Dietary Fiber, One of the Most Important Nutrients for the Gut Microbiota	85
Development of ‘Lignin-First’ Approaches for the Valorization of Lignocellulosic Biomass	85
Common Trends and Differences in Antioxidant Activity Analysis of Phenolic Substances Using Single Electron Transfer Based Assays	85
Therapeutic Emergence of Rhein as a Potential Anticancer Drug: A Review of Its Molecular Targets and Anticancer Properties	84
Preparation and Antimicrobial Activity of Chitosan and Its Derivatives: A Concise Review	84
Biocide Use in the Antimicrobial Era: A Review	84
Electrostatic Potential Topology for Probing Molecular Structure, Bonding and Reactivity	83
The Therapeutic Potential of Psilocybin	83
Revisiting the Physicochemical Properties and Applications of Deep Eutectic Solvents	83
Quantitative NMR-Based Biomedical Metabolomics: Current Status and Applications	83
Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid	83
The Hallmarks of Flavonoids in Cancer	83
The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review	83
Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases	83
Neuroprotective Effect of SGLT2 Inhibitors	83
Amorphous Co-Mo-B Film: A High-Active Electrocatalyst for Hydrogen Generation in Alkaline Seawater	82
Edible Mushrooms as Functional Ingredients for Development of Healthier and More Sustainable Muscle Foods: A Flexitarian Approach	82
Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L.) and Clues to Its Anti-COVID-19 Utility	82
Biased Opioid Ligands	81
Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics	81
The Concept of Folic Acid in Health and Disease	81
An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives	81
Green Synthesis of Zinc Oxide Nanoparticles from Pomegranate (Punica granatum) Extracts and Characterization of Their Antibacterial Activity	81
Plant Secondary Metabolites: An Opportunity for Circular Economy	81
Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies	81
Trending Topics on Coumarin and Its Derivatives in 2020	81
Meso/Microporous Carbons from Conjugated Hyper-Crosslinked Polymers Based on Tetraphenylethene for High-Performance CO2 Capture and Supercapacitor	80
Role of Melatonin in Plant Tolerance to Soil Stressors: Salinity, pH and Heavy Metals	79
Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications	79
Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism	78
Vitamin D Signaling in Inflammation and Cancer: Molecular Mechanisms and Therapeutic Implications	78
Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review	78
Review of Functional and Pharmacological Activities of Berries	77
All-Cellulose Composites: A Review of Recent Studies on Structure, Properties and Applications	77
Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties	77
Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2	77
The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders	77
Review on the Biological Detoxification of Mycotoxins Using Lactic Acid Bacteria to Enhance the Sustainability of Foods Supply	77
The Second Life of Citrus Fruit Waste: A Valuable Source of Bioactive Compounds	76
Role of Inositols and Inositol Phosphates in Energy Metabolism	76
Influence of Non-Saccharomyces on Wine Chemistry: A Focus on Aroma-Related Compounds	76
Design, Synthesis, Docking, DFT, MD Simulation Studies of a New Nicotinamide-Based Derivative: In Vitro Anticancer and VEGFR-2 Inhibitory Effects	76
Gum Tragacanth (GT): A Versatile Biocompatible Material beyond Borders	76
Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways	76
Recovery of Banana Waste-Loss from Production and Processing: A Contribution to a Circular Economy	75
l-Aspartate: An Essential Metabolite for Plant Growth and Stress Acclimation	75
Size and Shape-Dependent Antimicrobial Activities of Silver and Gold Nanoparticles: A Model Study as Potential Fungicides	75
Zinc Oxide Nanoparticles Alleviate Chilling Stress in Rice (Oryza Sativa L.) by Regulating Antioxidative System and Chilling Response Transcription Factors	75
Superoxide Dismutase Administration: A Review of Proposed Human Uses	75
Globally Approved EGFR Inhibitors: Insights into Their Syntheses, Target Kinases, Biological Activities, Receptor Interactions, and Metabolism	75
Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents	75
Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics	75
Ebselen and Analogues: Pharmacological Properties and Synthetic Strategies for Their Preparation	74
Methods to Enhance the Metabolic Stability of Peptide-Based PET Radiopharmaceuticals	74
A Review of Microalgae- and Cyanobacteria-Based Biodegradation of Organic Pollutants	74
Quinoxaline Derivatives as Antiviral Agents: A Systematic Review	74
Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations	74
The Role of the Inflammasome in Neurodegenerative Diseases	74
Antimicrobial Activities of Lipopeptides and Polyketides of Bacillus velezensis for Agricultural Applications	74
Recent Trends in Enzyme Immobilization—Concepts for Expanding the Biocatalysis Toolbox	74
Utilization of Polymer-Lipid Hybrid Nanoparticles for Targeted Anti-Cancer Therapy	74
Glutathione in Brain Disorders and Aging	74
The Wonderful Activities of the Genus Mentha: Not Only Antioxidant Properties	74
Imidazoles as Potential Anticancer Agents: An Update on Recent Studies	74
Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets	74
Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy	73
Production of Plant Beneficial and Antioxidants Metabolites by Klebsiellavariicola under Salinity Stress	73
Bioethanol Production from Lignocellulosic Biomass—Challenges and Solutions	73
Selenium: An Antioxidant with a Critical Role in Anti-Aging	72
Difunctionalization of Alkenes and Alkynes via Intermolecular Radical and Nucleophilic Additions	72
Design Strategies of Conductive Hydrogel for Biomedical Applications	72
One Hundred Faces of Geraniol	72
Polyethylene Glycol Functionalized Graphene Oxide Nanoparticles Loaded with Nigella sativa Extract: A Smart Antibacterial Therapeutic Drug Delivery System	72
Green Fabrication of Zinc Oxide Nanoparticles Using Phlomis Leaf Extract: Characterization and In Vitro Evaluation of Cytotoxicity and Antibacterial Properties	71
Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy	71
Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective	71
An Overview of the Role of Adipokines in Cardiometabolic Diseases	71
The Role of Taurine in Mitochondria Health: More Than Just an Antioxidant	71
Efficacy of Natural Deep Eutectic Solvents for Extraction of Hydrophilic and Lipophilic Compounds from Fucus vesiculosus	71
Natural Products as Anticancer Agents: Current Status and Future Perspectives	71
Antiviral and Immunomodulatory Effects of Phytochemicals from Honey against COVID-19: Potential Mechanisms of Action and Future Directions	70