Cellular and Molecular Life Sciences

Article	Citations
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling	565
The multifaceted role of reactive oxygen species in tumorigenesis	282
Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics	183
Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis	172
Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses	160
Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance	126
Functional circuits and signal processing in the enteric nervous system	116
The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens	111
The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass	109
Arginine-dependent immune responses	101
The complement system in age-related macular degeneration	100
Gut microbiota-derived tryptophan metabolism mediates renal fibrosis by aryl hydrocarbon receptor signaling activation	95
Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions	93
Mitophagy in tumorigenesis and metastasis	93
Type I interferon-mediated tumor immunity and its role in immunotherapy	92
Metabolism and growth adaptation to environmental conditions in Drosophila	91
Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders	88
Alzheimer’s pathogenic mechanisms and underlying sex difference	87
The role of bile acids in carcinogenesis	84
Histone acetylation dynamics regulating plant development and stress responses	79
Ins and outs of AlphaFold2 transmembrane protein structure predictions	79
The lysosome as an imperative regulator of autophagy and cell death	75
Stress granule subtypes: an emerging link to neurodegeneration	75
Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses	74
Advances in research on ACE2 as a receptor for 2019-nCoV	72

Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies	70
Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance	70
The regulatory roles of p53 in cardiovascular health and disease	67
New insights into anti-Müllerian hormone role in the hypothalamic–pituitary–gonadal axis and neuroendocrine development	67
Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges	66
Termite evolution: mutualistic associations, key innovations, and the rise of Termitidae	65
The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice	65
Insulin granule biogenesis and exocytosis	63
Mitochondrial quality control: from molecule to organelle	62
Mettl14 mediates the inflammatory response of macrophages in atherosclerosis through the NF-κB/IL-6 signaling pathway	61
An overview of signaling pathways regulating YAP/TAZ activity	61
The enteric nervous system in gastrointestinal disease etiology	60
The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective	60
Autophagy and apoptosis cascade: which is more prominent in neuronal death?	59
G-quadruplex DNA: a novel target for drug design	57
Immune cells lacking Y chromosome show dysregulation of autosomal gene expression	56
The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons	56
PDGF receptor mutations in human diseases	56
Recent progress in mass spectrometry-based strategies for elucidating protein–protein interactions	56
Genome-wide association studies: assessing trait characteristics in model and crop plants	54
The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis	54
Targeting the pathways of regulated necrosis: a potential strategy for alleviation of cardio-cerebrovascular injury	53
Ultrastructural modifications induced by SARS-CoV-2 in Vero cells: a kinetic analysis of viral factory formation, viral particle morphogenesis and virion release	53
An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis	52
Programmed genome rearrangements in ciliates	50
GABAergic signaling by cells of the immune system: more the rule than the exception	50
Electrophysiology of ionotropic GABA receptors	50
Viral pathogen-induced mechanisms to antagonize mammalian interferon (IFN) signaling pathway	50
tRNA-derived fragments (tRFs): establishing their turf in post-transcriptional gene regulation	49
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies	48
Mechanisms of fungal dissemination	48
Multi-substrate selectivity based on key loops and non-homologous domains: new insight into ALKBH family	47
METTL3 promotes oxaliplatin resistance of gastric cancer CD133+ stem cells by promoting PARP1 mRNA stability	47
Recent advances in liposome formulations for breast cancer therapeutics	45
Vaccination against the Epstein–Barr virus	45
Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives	45
Liquid–liquid phase separation as an organizing principle of intracellular space: overview of the evolution of the cell compartmentalization concept	45
The protective effect of selenoprotein M on non-alcoholic fatty liver disease: the role of the AMPKα1–MFN2 pathway and Parkin mitophagy	45
DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity	45
DYRK1A: a down syndrome-related dual protein kinase with a versatile role in tumorigenesis	45
Age-associated B cells in autoimmune diseases	44
Dysregulated signalling pathways in innate immune cells with cystic fibrosis mutations	44
Selective autophagy as a therapeutic target for neurological diseases	43
L-serine synthesis via the phosphorylated pathway in humans	43
Multidrug efflux transporter ABCG2: expression and regulation	43
Anti-inflammatory effect of SGLT-2 inhibitors via uric acid and insulin	43
MicroRNA-34a: the bad guy in age-related vascular diseases	43
Intercellular trafficking via plasmodesmata: molecular layers of complexity	43
Adipokines, adiposity, and atherosclerosis	43
Sensing, signaling and surviving mitochondrial stress	42

Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma	41
Extracellular vesicles and amyotrophic lateral sclerosis: from misfolded protein vehicles to promising clinical biomarkers	41
AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3	40
A look into retinal organoids: methods, analytical techniques, and applications	40
The circadian clock and metabolic homeostasis: entangled networks	40
The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogenesis	40
NEAT1 polyA-modulating antisense oligonucleotides reveal opposing functions for both long non-coding RNA isoforms in neuroblastoma	40
Nonsense suppression therapies in human genetic diseases	40
TP63 links chromatin remodeling and enhancer reprogramming to epidermal differentiation and squamous cell carcinoma development	40
Activation of stress response axis as a key process in environment-induced sex plasticity in fish	40
The pre-metastatic niche in lymph nodes: formation and characteristics	40
Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants	40
Regulation of maternal–fetal metabolic communication	39
Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology	39
The dark-side of the outside: how extracellular heat shock proteins promote cancer	39
Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR	39
Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis	38
CDK9 keeps RNA polymerase II on track	38
uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells	38
Heparanase, cell signaling, and viral infections	38
Dissecting the initiation of female meiosis in the mouse at single-cell resolution	37
Regulation of histone deacetylase activities and functions by phosphorylation and its physiological relevance	37
Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets	37
Metabolomics and health: from nutritional crops and plant-based pharmaceuticals to profiling of human biofluids	37
GAGA factor: a multifunctional pioneering chromatin protein	36
5-Aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism	36
Mechanisms of neuronal dysfunction in HIV-associated neurocognitive disorders	36
An emerging potential of metabolomics in multiple sclerosis: a comprehensive overview	35
Molecular mechanisms of doxorubicin-induced cardiotoxicity: novel roles of sirtuin 1-mediated signaling pathways	35
Context-dependent roles of YAP/TAZ in stem cell fates and cancer	35
Metabolic heterogeneity and adaptability in brain tumors	35
At the heart of mitochondrial quality control: many roads to the top	35
Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases	34
Aquaporin-3 is involved in NLRP3-inflammasome activation contributing to the setting of inflammatory response	34
Initiation and progression of α-synuclein pathology in Parkinson’s disease	34
Cortical bone development, maintenance and porosity: genetic alterations in humans and mice influencing chondrocytes, osteoclasts, osteoblasts and osteocytes	34
miRNA regulation of social and anxiety-related behaviour	34
Estrogen receptor-α signaling in post-natal mammary development and breast cancers	33
Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation	33
WNT and NOTCH signaling in human trophoblast development and differentiation	33
Genomics of Alzheimer’s disease implicates the innate and adaptive immune systems	33
New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis	33
Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies	33
Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress	33
Transcription factor networks in trophoblast development	33
TGF-β1 promotes epithelial-to-mesenchymal transition and stemness of prostate cancer cells by inducing PCBP1 degradation and alternative splicing of CD44	33
The wide and growing range of lamin B-related diseases: from laminopathies to cancer	33
Oxidative stress response pathways in fungi	33
Sirtuins and the circadian clock interplay in cardioprotection: focus on sirtuin 1	32
Regulatory mechanisms of neutrophil migration from the circulation to the airspace	32
Mitochondrial network remodeling: an important feature of myogenesis and skeletal muscle regeneration	31
Plastin 3 in health and disease: a matter of balance	31
Snake venom phospholipase A2s exhibit strong virucidal activity against SARS-CoV-2 and inhibit the viral spike glycoprotein interaction with ACE2	31
The role of micropeptides in biology	31
Epigenetic regulations in mammalian spermatogenesis: RNA-m6A modification and beyond	31
Integrin-linked kinase (ILK): the known vs. the unknown and perspectives	31
The Hsp70–Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration	31
The impact of obesity on adipocyte-derived extracellular vesicles	31
The role of SLC transporters for brain health and disease	31
Mechanisms that regulate the activities of TET proteins	31
Hippo/YAP signaling pathway protects against neomycin-induced hair cell damage in the mouse cochlea	31
Contribution of ADAM17 and related ADAMs in cardiovascular diseases	31
Infection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19	30
Emerging role of S100B protein implication in Parkinson’s disease pathogenesis	30
Early human trophoblast development: from morphology to function	30
The double-membrane vesicle (DMV): a virus-induced organelle dedicated to the replication of SARS-CoV-2 and other positive-sense single-stranded RNA viruses	30
Hematopoietic responses to SARS-CoV-2 infection	30
Functional impact of HIV-1 Tat on cells of the CNS and its role in HAND	30
Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview	30
Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury	30
Mitochondrial function in spinal cord injury and regeneration	30
Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells	30
The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis	29
Motile cilia genetics and cell biology: big results from little mice	29
DExD/H-box helicases: multifunctional regulators in antiviral innate immunity	29
Follicular helper T cells: potential therapeutic targets in rheumatoid arthritis	29
Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection	29
The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses	29
Approach for in vivo delivery of CRISPR/Cas system: a recent update and future prospect	29
Revisiting respiratory syncytial virus’s interaction with host immunity, towards novel therapeutics	29

Differential effects of putative N-glycosylation sites in human Tau on Alzheimer’s disease-related neurodegeneration	28
Autophagy and the endolysosomal system in presynaptic function	28
Senescence under appraisal: hopes and challenges revisited	28
The role of metabolic reprogramming in tubular epithelial cells during the progression of acute kidney injury	28
Control of the eIF4E activity: structural insights and pharmacological implications	28
Mitochondrial microRNA (MitomiRs) in cancer and complex mitochondrial diseases: current status and future perspectives	28
Post-transcriptional regulation in spermatogenesis: all RNA pathways lead to healthy sperm	28
Structure and function of adenosine receptor heteromers	28
Role of tertiary lymphoid organs in the regulation of immune responses in the periphery	28
Meiotic sex chromosome inactivation and the XY body: a phase separation hypothesis	28
Vault RNAs: hidden gems in RNA and protein regulation	28
Mitochondrial dynamics in cancer stem cells	27
Animal regeneration in the era of transcriptomics	27
Tuning the ignition of CAR: optimizing the affinity of scFv to improve CAR-T therapy	27
The crosstalk between viral RNA- and DNA-sensing mechanisms	27
The hemogenic endothelium: a critical source for the generation of PSC-derived hematopoietic stem and progenitor cells	27
SIRT7 in the aging process	27
ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation	27
Systems biology of resurrection plants	27
eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity	26
Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation	26
Twenty years of research on HPV vaccines based on genetically modified lactic acid bacteria: an overview on the gut-vagina axis	26
Engineered-extracellular vesicles as an optimistic tool for microRNA delivery for osteoarthritis treatment	26
Experimental colonization with Blastocystis ST4 is associated with protective immune responses and modulation of gut microbiome in a DSS-induced colitis mouse model	26
Alpha and beta myosin isoforms and human atrial and ventricular contraction	26
Mesenchymal stem cell-based treatments for COVID-19: status and future perspectives for clinical applications	26
A comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine	26
How trophoblasts fuse: an in-depth look into placental syncytiotrophoblast formation	26
The effects of codon bias and optimality on mRNA and protein regulation	26
Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle	26
The formin INF2 in disease: progress from 10 years of research	26
What can urinary exosomes tell us?	26
Neurovascular regulation in diabetic retinopathy and emerging therapies	25
Growth regulation by amino acid transporters in Drosophila larvae	25
Platelet-released extracellular vesicles: the effects of thrombin activation	25
Vitamin K1 inhibits ferroptosis and counteracts a detrimental effect of phenprocoumon in experimental acute kidney injury	25
Macrophages evoke autophagy of hepatic stellate cells to promote liver fibrosis in NAFLD mice via the PGE2/EP4 pathway	25
Contribution of specific ceramides to obesity-associated metabolic diseases	25
Overexpression of laminin-5 gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade	25
Anillin is an emerging regulator of tumorigenesis, acting as a cortical cytoskeletal scaffold and a nuclear modulator of cancer cell differentiation	25
RIPK3 signaling and its role in the pathogenesis of cancers	25
Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases	25
Genome-wide mRNA profiling identifies X-box-binding protein 1 (XBP1) as an IRE1 and PUMA repressor	25
Mitochondrial dynamics, positioning and function mediated by cytoskeletal interactions	24
KDEL receptor is a cell surface receptor that cycles between the plasma membrane and the Golgi via clathrin-mediated transport carriers	24
Sterile inflammation in thoracic transplantation	24
Neural glycomics: the sweet side of nervous system functions	24
SOX9 in organogenesis: shared and unique transcriptional functions	24
Revealing the hidden reality of the mammalian 12-h ultradian rhythms	24
Immune responses and therapeutic options in psoriasis	24
Sonic hedgehog signaling in astrocytes	24
Transcriptional enhancers and their communication with gene promoters	24
Metabolic reprogramming consequences of sepsis: adaptations and contradictions	24
Cytochrome P450 CYP709C56 metabolizing mesosulfuron-methyl confers herbicide resistance in Alopecurus aequalis	24
Extracellular vesicle release and uptake by the liver under normo- and hyperlipidemia	23
Mesenchymal stem cell-mediated transfer of mitochondria: mechanisms and functional impact	23
Outlook on next-generation probiotics from the human gut	23
ADP-heptose: a bacterial PAMP detected by the host sensor ALPK1	23
The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour	23
Mfn2-mediated mitochondrial fusion promotes autophagy and suppresses ovarian cancer progression by reducing ROS through AMPK/mTOR/ERK signaling	23
miR-146a regulates insulin sensitivity via NPR3	23
Fly for ALS: Drosophila modeling on the route to amyotrophic lateral sclerosis modifiers	23
Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types	23
Design of an improved universal signal peptide based on the α-factor mating secretion signal for enzyme production in yeast	23
Glial cells in Parkinson´s disease: protective or deleterious?	23
Structural and functional comparison of magnesium transporters throughout evolution	22
The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa	22
The structure and phase of tau: from monomer to amyloid filament	22
Sestrin2 protects against lethal sepsis by suppressing the pyroptosis of dendritic cells	22
SOX2-OT induced by PAI-1 promotes triple-negative breast cancer cells metastasis by sponging miR-942-5p and activating PI3K/Akt signaling	22
Cytokine signaling convergence regulates the microglial state transition in Alzheimer’s disease	22
Effects of pH alterations on stress- and aging-induced protein phase separation	22
Inhibitory control in neuronal networks relies on the extracellular matrix integrity	22
Idiopathic pulmonary fibrosis and systemic sclerosis: pathogenic mechanisms and therapeutic interventions	22
Approaches for characterizing and tracking hospital-associated multidrug-resistant bacteria	22
Synaptic homeostats: latent plasticity revealed at the Drosophila neuromuscular junction	22
BCL2L13: physiological and pathological meanings	22
Upregulation of MDH1 acetylation by HDAC6 inhibition protects against oxidative stress-derived neuronal apoptosis following intracerebral hemorrhage	22
SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants	21
Antiviral activities and applications of ribosomally synthesized and post-translationally modified peptides (RiPPs)	21
Compartmentalized replication organelle of flavivirus at the ER and the factors involved	21
The role of mitonuclear incompatibilities in allopatric speciation	21
Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action	21
IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymore	21
Speaking the language of lipids: the cross-talk between plants and pathogens in defence and disease	21
Mechanisms and therapeutic potential of interactions between human amyloids and viruses	21
Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes	21
Twist1 regulates macrophage plasticity to promote renal fibrosis through galectin-3	21
Non-canonical roles of canonical telomere binding proteins in cancers	21
ER residential chaperone GRP78 unconventionally relocalizes to the cell surface via endosomal transport	20
Cardiac regenerative capacity: an evolutionary afterthought?	20
Mechanisms underlying pre- and postnatal development of the vomeronasal organ	20
Nuclear organization and regulation of the differentiated state	20
Mechanisms of meiotic drive in symmetric and asymmetric meiosis	20
ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform	20