Biological Chemistry

Article	Citations
Bioprospecting hydroxylated chalcones in in vitro model of ischemia-reoxygenation and probing NOX4 interactions via molecular docking	59
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Astrocytic potassium and calcium channels as integrators of the inflammatory and ischemic CNS microenvironment	26
Highlight: young research groups in Germany – 5th edition	26
Infection, inflammation and thrombosis: a review of potential mechanisms mediating arterial thrombosis associated with influenza and severe acute respiratory syndrome coronavirus 2	25
Yme2, a putative RNA recognition motif and AAA+ domain containing protein, genetically interacts with the mitochondrial protein export machinery	22
LncRNA-p21 suppresses cell proliferation and induces apoptosis in gastric cancer by sponging miR-514b-3p and up-regulating ARHGEF9 expression	21
Synthesis and biological characterization of a new fluorescent probe for vesicular trafficking based on polyazamacrocycle derivative	18
Loss of respiratory complex I subunit NDUFB10 affects complex I assembly and supercomplex formation	18
Altered population activity and local tuning heterogeneity in auditory cortex of Cacna2d3-deficient mice	17
Characterization of the scavenger cell proteome in mouse and rat liver	17
Anti-inflammatory dihydroxanthones from a Diaporthe species	16
Structural homology of mite profilins to plant profilins is not indicative of allergic cross-reactivity	15
Exceptionally versatile take II: post-translational modifications of lysine and their impact on bacterial physiology	15
SRPK1 promotes cell proliferation and tumor growth of osteosarcoma through activation of the NF-κB signaling pathway	15
Protein transport along the presequence pathway	14
Diselenide-derivative of 3-pyridinol targets redox enzymes leading to cell cycle deregulation and apoptosis in A549 cells	14
Mechanism of hypoxia-induced exosome circ_0051799 regulating the progression of lung adenocarcinoma	14
Development of an enabling platform biotechnology for the production of proteins	14
Implications of TRPM3 and TRPM8 for sensory neuron sensitisation	13
The Mycobacterium tuberculosis prolyl dipeptidyl peptidase cleaves the N-terminal peptide of the immunoprotein CXCL-10	13
Functional characterisation of two receptor interaction determinants in human thymic stromal lymphopoietin	13
Broadened substrate specificity of bacterial dipeptidyl-peptidase 7 enables release of half of all dipeptide combinations from peptide N-termini	13

Simultaneous spectral illumination of microplates for high-throughput optogenetics and photobiology	12
Asymmetric horseshoe-like assembly of peroxisomal yeast oxalyl-CoA synthetase	12
Molecular determinants of health and disease	12
Molecular determinants of protein half-life in chloroplasts with focus on the Clp protease system	12
Influence of inflammatory processes on thalamocortical activity	12
Characterization of hepatic zonation in mice by mass-spectrometric and antibody-based proteomics approaches	12
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Computational resolution in single molecule localization – impact of noise level and emitter density	12
Highlights in biochemistry Bochum 2022	11
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Dynamics of the translocation pore of the human peroxisomal protein import machinery	11
Unpaired cysteine insertions favor transmembrane dimerization and induce ligand-independent constitutive cytokine receptor signaling	11
Machine learning based disease prediction from genotype data	11
Highlight: structure and function of the peroxisomal translocon	11
Comparative studies of soluble and immobilized Fe(III) heme-peptide complexes as alternative heterogeneous biocatalysts	11
A tailored cytochrome P450 monooxygenase from Gordonia rubripertincta CWB2 for selective aliphatic monooxygenation	11
The cAMP responsive element modulator (CREM) is a regulator of CD4+ T cell function	11
Detection of a 7SL RNA-derived small non-coding RNA using Molecular Beacons in vitro and in cells	11
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Pathogenic missense variants of CSNK2B associated with Poirier-Bienvenu neurodevelopmental disorder impact differently on CK2 holoenzyme formation	10
Dynamic phospho-modification of viral proteins as a crucial regulatory layer of influenza A virus replication and innate immune responses	10
Methionine restriction attenuates the migration and invasion of gastric cancer cells by inhibiting nuclear p65 translocation through TRIM47	10
Role of the gut microbiota in airway immunity and host defense against respiratory infections	10
Structure and phase separation of the C-terminal domain of RNA polymerase II	10
Protein engineering & design: hitting new heights	10
The nascent polypeptide-associated complex (NAC) as regulatory hub on ribosomes	9
The emerging role of ATP as a cosolute for biomolecular processes	9
Tumor cell lysis and synergistically enhanced antibody-dependent cell-mediated cytotoxicity by NKG2D engagement with a bispecific immunoligand targeting the HER2 antigen	9
Structures and nucleic acid-binding preferences of the eukaryotic ARID domain	9
The Zika virus infection remodels the expression of the synaptotagmin-9 secretory protein	9
The role of the Na+/Ca2+-exchanger (NCX) in cancer-associated fibroblasts	9
Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation	9
The phytochemical plumbagin reciprocally modulates osteoblasts and osteoclasts	9
Inhibition of miR-143-3p alleviates myocardial ischemia reperfusion injury via limiting mitochondria-mediated apoptosis	8
Structural insights into the repair mechanism of AGT for methyl-induced DNA damage	8
The role of ADAM17 during liver damage	8
Protein kinase CK2 contributes to glucose homeostasis	8
Structural basis of Alzheimer β-amyloid peptide recognition by engineered lipocalin proteins with aggregation-blocking activity	8
Highlight: new developments in immunoengineering	8
KCTD5 regulates Ikaros degradation induced by chemotherapeutic drug etoposide in hematological cells	8
Insights in caveolae protein structure arrangements and their local lipid environment	8
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In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs	8
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A guide to designing photocontrol in proteins: methods, strategies and applications	7
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Improvement of wound healing by the development of ECM-inspired biomaterial coatings and controlled protein release	7
The paracaspase MALT1 in psoriasis	7
Eukaryotic tRNA splicing – one goal, two strategies, many players	7
Microtubules as a signal hub for axon growth in response to mechanical force	7

Frontmatter	7
A liquid-culture-based screening approach to study compounds affecting inflammatory processes in Caenorhabditis elegans	7
Unfolded protein responses in Chlamydomonas reinhardtii	7
Membrane binding and pore forming insertion of PEX5 into horizontal lipid bilayer	6
Rodent models for mood disorders – understanding molecular changes by investigating social behavior	6
Post-translational lysine ac(et)ylation in health, ageing and disease	6
Long non-coding RNA FAM66C regulates glioma growth via the miRNA/LATS1 signaling pathway	6
Highlight: how to synthesize, assemble and regulate ribonucleoprotein-complexes	6
The relevance of adhesion G protein-coupled receptors in metabolic functions	6
Extracellular hemin is a reverse use-dependent gating modifier of cardiac voltage-gated Na+ channels	6
Extracellular stimulation of lung fibroblasts with arachidonic acid increases interleukin 11 expression through p38 and ERK signaling	6
Bioinformatics in theory and application – highlights of the 36th German Conference on Bioinformatics	6
Atomistic insight into the essential binding event of ACE2-derived peptides to the SARS-CoV-2 spike protein	6
Effect of myeloperoxidase oxidation and N-homocysteinylation of high-density lipoprotein on endothelial repair function	6
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Distinct conformational and energetic features define the specific recognition of (di)aromatic peptide motifs by PEX14	6
Pathological and physiological roles of ADP-ribosylation: established functions and new insights	6
Molecular simulations of DEAH-box helicases reveal control of domain flexibility by ligands: RNA, ATP, ADP, and G-patch proteins	6
The BCL11A transcription factor stimulates the enzymatic activities of the OGG1 DNA glycosylase	6
Epitranscriptomic modifications in acute myeloid leukemia: m6A and 2′-O-methylation as targets for novel therapeutic strategies	6
Small-molecule metabolites in SARS-CoV-2 treatment: a comprehensive review	6
Interaction of RTX toxins with the host cell plasma membrane	6
Protein persulfidation in plants: mechanisms and functions beyond a simple stress response	5
Insights into structure, affinity, specificity, and function of GAG-protein interactions through the chemoenzymatic preparation of defined sulfated oligohyaluronans	5
Study of two glycosyltransferases related to polysaccharide biosynthesis in Rhodococcus jostii RHA1	5
Application of RtcB ligase to monitor self-cleaving ribozyme activity by RNA-seq	5
Modulation of self-organizing circuits at deforming membranes by intracellular and extracellular factors	5
Interaction of nucleoporins with nuclear transport receptors: a structural perspective	5
Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features	5
MicroRNA-6838-5p suppresses the self-renewal and metastasis of human liver cancer stem cells through downregulating CBX4 expression and inactivating ERK signaling	5
The evolution and diversification of the Hsp90 co-chaperone system	5
The antioxidant Rutin counteracts the pathological impact of α-synuclein on the enteric nervous system in vitro	5
Collagen/glycosaminoglycan-based matrices for controlling skin cell responses	5
Cell-type specific anti-cancerous effects of nitro-oleic acid and its combination with gamma irradiation	5
Analysis of cell cycle stage, replicated DNA, and chromatin-associated proteins using high-throughput flow cytometry	5
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The promise of genetic screens in human in vitro brain models	5
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CK2 control of human papillomavirus life cycles	5
Chemerin – exploring a versatile adipokine	5
Signal transduction in health and disease	5
Highlight: on the past and the future of cellular microcompartments	5
Lymphotoxin-β-receptor (LTβR) signaling on hepatocytes is required for liver regeneration after partial hepatectomy	5
Corrigendum to: Emerging mechanisms of drug-induced phospholipidosis	5
NF90/NFAR (nuclear factors associated with dsRNA) – a new methylation substrate of the PRMT5-WD45-RioK1 complex	5
The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transit	5
Structure and function of spliceosomal DEAH-box ATPases	4
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Cathepsin L-mediated EGFR cleavage affects intracellular signalling pathways in cancer	4
Celastrol inhibits angiogenesis and the biological processes of MDA-MB-231 cells via the DEGS1/S1P signaling pathway	4
Men who stare at bone: multimodal monitoring of bone healing	4
LINC00858 facilitates formation of hepatic metastases from colorectal cancer via regulating the miR-132-3p/IGF2BP1 axis	4
The many faces of ribosome translocation along the mRNA: reading frame maintenance, ribosome frameshifting and translational bypassing	4
Expanded profiling of β-lactam selectivity for penicillin-binding proteins in Streptococcus pneumoniae D39	4
Inhibition of Chk1 stimulates cytotoxic action of platinum-based drugs and TRAIL combination in human prostate cancer cells	4
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Transfer RNA processing – from a structural and disease perspective	4
Illuminating the brain-genetically encoded single wavelength fluorescent biosensors to unravel neurotransmitter dynamics	4
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Investigation of the P1′ and P2′ sites of IQF substrates and their selectivity toward 20S proteasome subunits	4
Interactions of Na+/taurocholate cotransporting polypeptide with host cellular proteins upon hepatitis B and D virus infection: novel potential targets for antiviral therapy	4
Two-photon fluorescent turn-on probes for highly efficient detection and profiling of thiols in live cells and tissues	4
Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies	4
The mitochondrial intermembrane space – a permanently proteostasis-challenged compartment	4
Exploring the biological potential of the brominated indenoindole MC11 and its interaction with protein kinase CK2	4
M2 macrophages-derived exosomal miR-3917 promotes the progression of lung cancer via targeting GRK6	4
Fibrillar biopolymer-based scaffolds to study macrophage-fibroblast crosstalk in wound repair	3
Highlight: chemical biology of ion channels	3
Drug development for neurodegenerative diseases	3
Comparison of human PEX knockout cell lines suggests a dual role of PEX1 in peroxisome biogenesis	3
Molecular insights into endolysosomal microcompartment formation and maintenance	3
Heme delivery to heme oxygenase-2 involves glyceraldehyde-3-phosphate dehydrogenase	3
New lipophilic organic nitrates: candidates for chronic skin disease therapy	3
Neprilysin 4: an essential peptidase with multifaceted physiological relevance	3
Starting the engine of the powerhouse: mitochondrial transcription and beyond	3
Features of yeast RNA polymerase I with special consideration of the lobe binding subunits	3
Biochemical evidence for conformational variants in the anti-viral and pro-metastatic protein IFITM1	3
Synthesis of the ribosomal RNA precursor in human cells: mechanisms, factors and regulation	3
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Autophagic and non-autophagic functions of the Saccharomyces cerevisiae PROPPINs Atg18, Atg21 and Hsv2	3

A CK2α′ mutant indicating why CK2α and CK2α′, the isoforms of the catalytic subunit of human protein kinase CK2, deviate in affinity to CK2β	3
Controllers of cutaneous regulatory T cells: ultraviolet radiation and the skin microbiome	3
Mycobacterial type VII secretion systems	3
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Unclogging of the TOM complex under import stress	3
The proteostasis burden of aneuploidy	3
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Nitazoxanide inhibits osteosarcoma cells growth and metastasis by suppressing AKT/mTOR and Wnt/β-catenin signaling pathways	2
GPI-anchored serine proteases: essential roles in development, homeostasis, and disease	2
Good things come to those who bait: the peroxisomal docking complex	2
Epithelial-mesenchymal transition and H2O2 signaling – a driver of disease progression and a vulnerability in cancers	2
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Time- and dose-dependent effects of CIGB-300 on the proteome of lung squamous cell carcinoma	2
EGFR binding Fc domain-drug conjugates: stable and highly potent cytotoxic molecules mediate selective cell killing	2
Novel insights into heme binding to hemoglobin	2
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The role of mycotoxins in neurodegenerative diseases: current state of the art and future perspectives of research	2
Highlight: Young research groups in Germany – 4th edition	2
The mitochondrial unfolded protein response: acting near and far	2
Microwave characterization of aqueous amino acid solutions using the multifrequency WGM resonator technique	2
Advances in preclinical TCR characterization: leveraging cell avidity to identify functional TCRs	2
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Nanoscale organization of CaV2.1 splice isoforms at presynaptic terminals: implications for synaptic vesicle release and synaptic facilitation	2
Trispecific antibodies produced from mAb2 pairs by controlled Fab-arm exchange	2
A primer on heme biosynthesis	2
The extracellular region of bovine milk butyrophilin exhibits closer structural similarity to human myelin oligodendrocyte glycoprotein than to immunological BTN family receptors	2
LINC00520 up-regulates SOX5 to promote cell proliferation and invasion by miR-4516 in human hepatocellular carcinoma	2
Molecular determinants of therapy response of venetoclax-based combinations in acute myeloid leukemia	2
The good or the bad: an overview of autoantibodies in traumatic spinal cord injury	2
Structural insights into the modulation of PDGF/PDGFR-β complexation by hyaluronan derivatives	2
Heme research – the past, the present and the future	2
Schwann cells in neuromuscular in vitro models	2
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The human long non-coding RNA LINC00941 and its modes of action in health and disease	2
The DEAD-box RNA helicase Dbp5 is a key protein that couples multiple steps in gene expression	2
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Structure, function, and recombinant production of EGFL7	2
Setting up a data management infrastructure for bioimaging	2
Quantifying salt sensitivity	2
The Rauischholzhausen Transport Colloquium: membrane proteins from structure to function	2
Rational approaches towards inorganic and organometallic antibacterials	2