Biological Chemistry

Article	Citations
Frontmatter	56
Artificial metalloenzymes in a nutshell: the quartet for efficient catalysis	35
Emerging contributions of formyl peptide receptors to neurodegenerative diseases	33
Frontmatter	29
Epithelial-mesenchymal transition and H2O2 signaling – a driver of disease progression and a vulnerability in cancers	29
IL-24 inhibits the malignancy of human glioblastoma cells via destabilization of Zeb1	27
Frontmatter	26
Molecular mechanisms of vasculopathy and coagulopathy in COVID-19	24
Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry	24
LncRNA-p21 suppresses cell proliferation and induces apoptosis in gastric cancer by sponging miR-514b-3p and up-regulating ARHGEF9 expression	23
Unravelling the genetic links between Parkinson’s disease and lung cancer	20
Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators	20
Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features	19
Highlight: new developments in immunoengineering	19
Photochemical protein modification in complex biological environments: recent advances and considerations for future chemical methods development	18
Yme2, a putative RNA recognition motif and AAA+ domain containing protein, genetically interacts with the mitochondrial protein export machinery	17
Frontmatter	16
Good things come to those who bait: the peroxisomal docking complex	15
Frontmatter	15
How to draw the line – Raman spectroscopy as a tool for the assessment of biomedicines	14
The role of ADAM17 during liver damage	14
Corrigendum to: Emerging mechanisms of drug-induced phospholipidosis	14
Astrocytic potassium and calcium channels as integrators of the inflammatory and ischemic CNS microenvironment	14
Structural basis of Alzheimer β-amyloid peptide recognition by engineered lipocalin proteins with aggregation-blocking activity	14
The promise of genetic screens in human in vitro brain models	13

Infection, inflammation and thrombosis: a review of potential mechanisms mediating arterial thrombosis associated with influenza and severe acute respiratory syndrome coronavirus 2	13
Frontmatter	13
TRPM3 in the eye and in the nervous system – from new findings to novel mechanisms	13
Trispecific antibodies produced from mAb2 pairs by controlled Fab-arm exchange	12
Improvement of wound healing by the development of ECM-inspired biomaterial coatings and controlled protein release	12
iMLP, a predictor for internal matrix targeting-like sequences in mitochondrial proteins	12
Highlight: integrative structural biology of dynamic macromolecular assemblies	11
The archaeal Lsm protein from Pyrococcus furiosus binds co-transcriptionally to poly(U)-rich target RNAs	11
Highlight: young research groups in Germany – 5th edition	11
Bioprospecting hydroxylated chalcones in in vitro model of ischemia-reoxygenation and probing NOX4 interactions via molecular docking	11
Structural insights into the repair mechanism of AGT for methyl-induced DNA damage	11
Lymphotoxin-β-receptor (LTβR) signaling on hepatocytes is required for liver regeneration after partial hepatectomy	11
Evolutionary adaptation of DHFR via expression of enzyme isoforms with various binding properties and dynamics behavior: a bioinformatics and computational study	11
The human long non-coding RNA LINC00941 and its modes of action in health and disease	10
Drosophila collagens in specialised extracellular matrices	10
In-depth analysis of Gαs protein activity by probing different fluorescently labeled guanine nucleotides	10
Analysis of cell cycle stage, replicated DNA, and chromatin-associated proteins using high-throughput flow cytometry	10
Modulation of self-organizing circuits at deforming membranes by intracellular and extracellular factors	10
KCTD5 regulates Ikaros degradation induced by chemotherapeutic drug etoposide in hematological cells	10
Insights in caveolae protein structure arrangements and their local lipid environment	10
The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transit	10
Intracellular spatially-targeted chemical chaperones increase native state stability of mutant SOD1 barrel	10
Yeast Bxi1/Ybh3 mediates conserved mitophagy and apoptosis in yeast and mammalian cells: convergence in Bcl-2 family	9
Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABAAR density	9
Nanoscale organization of CaV2.1 splice isoforms at presynaptic terminals: implications for synaptic vesicle release and synaptic facilitation	9
New insights into the role of glycosaminoglycans in the endosteal bone microenvironment	9
In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs	9
MicroRNA-6838-5p suppresses the self-renewal and metastasis of human liver cancer stem cells through downregulating CBX4 expression and inactivating ERK signaling	8
Characterization of Kv1.2-mediated outward current in TRIP8b-deficient mice	8
M6A methylation-mediated elevation of SM22α inhibits the proliferation and migration of vascular smooth muscle cells and ameliorates intimal hyperplasia in type 2 diabetes mellitus	8
NF90/NFAR (nuclear factors associated with dsRNA) – a new methylation substrate of the PRMT5-WD45-RioK1 complex	8
In vitro evolution of myc-tag antibodies: in-depth specificity and affinity analysis of Myc1-9E10 and Hyper-Myc	8
EVADR ceRNA transcript variants upregulate WNT and PI3K signaling pathways in SW480 and HCT116 cells by sponging miR-7 and miR-29b	8
The role of lysosomes in lipid homeostasis	8
Interaction of nucleoporins with nuclear transport receptors: a structural perspective	8
Life sciences and mass spectrometry: some personal reflections	8
Loss of respiratory complex I subunit NDUFB10 affects complex I assembly and supercomplex formation	8
Highlight: on the past and the future of cellular microcompartments	8
The DEAD-box RNA helicase Dbp5 is a key protein that couples multiple steps in gene expression	8
A primer on heme biosynthesis	8
Diselenide-derivative of 3-pyridinol targets redox enzymes leading to cell cycle deregulation and apoptosis in A549 cells	8
Eukaryotic tRNA splicing – one goal, two strategies, many players	8
GPI-anchored serine proteases: essential roles in development, homeostasis, and disease	7
Modular peptide binders – development of a predictive technology as alternative for reagent antibodies	7
Frontmatter	7
Heme research – the past, the present and the future	7
12 years more than just skin and bones: the CRC Transregio 67	7
Frontmatter	7
Determinants of synergistic cell-cell interactions in bacteria	7
Unfolded protein responses in Chlamydomonas reinhardtii	7

Frontmatter	7
Microwave characterization of aqueous amino acid solutions using the multifrequency WGM resonator technique	6
Transfer RNA processing – from a structural and disease perspective	6
SRPK1 promotes cell proliferation and tumor growth of osteosarcoma through activation of the NF-κB signaling pathway	6
Mechanism of hypoxia-induced exosome circ_0051799 regulating the progression of lung adenocarcinoma	6
Structural homology of mite profilins to plant profilins is not indicative of allergic cross-reactivity	6
Tuning the network charge of biohybrid hydrogel matrices to modulate the release of SDF-1	6
Exploring the biological potential of the brominated indenoindole MC11 and its interaction with protein kinase CK2	6
Illuminating the brain-genetically encoded single wavelength fluorescent biosensors to unravel neurotransmitter dynamics	6
Men who stare at bone: multimodal monitoring of bone healing	6
Lefty A is involved in sunitinib resistance of renal cell carcinoma cells via regulation of IL-8	6
Development of an enabling platform biotechnology for the production of proteins	6
A liquid-culture-based screening approach to study compounds affecting inflammatory processes in Caenorhabditis elegans	6
Determination of membrane protein orientation upon liposomal reconstitution down to the single vesicle level	6
Frontmatter	6
Frontmatter	6
N6-methyladenosine-induced METTL1 promotes tumor proliferation via CDK4	6
Frontmatter	6
Acute-phase protein synthesis: a key feature of innate immune functions of the liver	5
A guide to designing photocontrol in proteins: methods, strategies and applications	5
Nitazoxanide inhibits osteosarcoma cells growth and metastasis by suppressing AKT/mTOR and Wnt/β-catenin signaling pathways	5
Chemical, pharmacodynamic and pharmacokinetic characterization of the GluN2B receptor antagonist 3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol – starting point for PET tracer d	5
Determination of free heme in stored red blood cells with an apo-horseradish peroxidase-based assay	5
Characterization of the scavenger cell proteome in mouse and rat liver	5
Cathepsin L-mediated EGFR cleavage affects intracellular signalling pathways in cancer	5
Assessment of the breadth of binding promiscuity of heme towards human proteins	5
Synthesis and biological characterization of a new fluorescent probe for vesicular trafficking based on polyazamacrocycle derivative	5
Using the yeast three-hybrid system for the identification of small molecule-protein interactions with the example of ethinylestradiol	5
Integrated machine learning and multimodal data fusion for patho-phenotypic feature recognition in iPSC models of dilated cardiomyopathy	5
Anti-inflammatory dihydroxanthones from a Diaporthe species	5
Microtubules as a signal hub for axon growth in response to mechanical force	5
Celastrol inhibits angiogenesis and the biological processes of MDA-MB-231 cells via the DEGS1/S1P signaling pathway	5
Molecular determinants of health and disease	5
HMGB1-RAGE axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte autophagy and apoptosis in diabetic mice	5
Altered population activity and local tuning heterogeneity in auditory cortex of Cacna2d3-deficient mice	5
Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies	5
Platelet-derived growth factor-stimulated pulmonary artery smooth muscle cells regulate pulmonary artery endothelial cell dysfunction through extracellular vesicle miR-409-5p	5
Exceptionally versatile take II: post-translational modifications of lysine and their impact on bacterial physiology	5
Heterogenous nuclear ribonucleoprotein D-like controls endothelial cell functions	5
The paracaspase MALT1 in psoriasis	5
Frontmatter	4
LINC00858 facilitates formation of hepatic metastases from colorectal cancer via regulating the miR-132-3p/IGF2BP1 axis	4
M2 macrophages-derived exosomal miR-3917 promotes the progression of lung cancer via targeting GRK6	4
Protein transport along the presequence pathway	4
Membrane binding and pore forming insertion of PEX5 into horizontal lipid bilayer	4
Biophysical applications in structural and molecular biology	4
The Mycobacterium tuberculosis prolyl dipeptidyl peptidase cleaves the N-terminal peptide of the immunoprotein CXCL-10	4
Highlight: Young research groups in Germany – 4th edition	4
Frontmatter	4
Investigation of the P1′ and P2′ sites of IQF substrates and their selectivity toward 20S proteasome subunits	4
On the reproducibility of enzyme reactions and kinetic modelling	4
In vitro osteogenic activities of sulfated derivative of polysaccharide extracted from Tamarindus indica L.	4
Two-photon fluorescent turn-on probes for highly efficient detection and profiling of thiols in live cells and tissues	4
MicroRNA-101-3p inhibits nasopharyngeal carcinoma cell proliferation and cisplatin resistance through ZIC5 down-regulation by targeting SOX2	4
Chemical biology in drug discovery	4
Frontmatter	4
Frontmatter	4
Frontmatter	4
Bioinformatics in theory and application – highlights of the 36th German Conference on Bioinformatics	4
Frontmatter	4
Frontmatter	4
Carnosic acid prevents heat stress-induced oxidative damage by regulating heat-shock proteins and apoptotic proteins in mouse testis	4
Extracellular hemin is a reverse use-dependent gating modifier of cardiac voltage-gated Na+ channels	4
Expanded profiling of β-lactam selectivity for penicillin-binding proteins in Streptococcus pneumoniae D39	4
Frontmatter	4
NMDA receptors – regulatory function and pathophysiological significance for pancreatic beta cells	4
The good or the bad: an overview of autoantibodies in traumatic spinal cord injury	4
Frontmatter	4
Towards correlative archaeology of the human mind	3
Advances in preclinical TCR characterization: leveraging cell avidity to identify functional TCRs	3
Frontmatter	3
Functional characterisation of two receptor interaction determinants in human thymic stromal lymphopoietin	3
Beyond CAR T cells: exploring alternative cell sources for CAR-like cellular therapies	3
The Rauischholzhausen Transport Colloquium: membrane proteins from structure to function	3
Bayesian methods in integrative structure modeling	3
Computational resolution in single molecule localization – impact of noise level and emitter density	3
The extracellular region of bovine milk butyrophilin exhibits closer structural similarity to human myelin oligodendrocyte glycoprotein than to immunological BTN family receptors	3
Visualization of the membrane surface and cytoskeleton of oligodendrocyte progenitor cell growth cones using a combination of scanning ion conductance and four times expansion microscopy	3
New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals	3
Implications of TRPM3 and TRPM8 for sensory neuron sensitisation	3

Rational approaches towards inorganic and organometallic antibacterials	3
Structural insights into the modulation of PDGF/PDGFR-β complexation by hyaluronan derivatives	3
Phosphorylation of the receptor protein Pex5p modulates import of proteins into peroxisomes	3
Schwann cells in neuromuscular in vitro models	3
Influence of inflammatory processes on thalamocortical activity	3
Investigation of the structure of regulatory proteins interacting with glycosaminoglycans by combining NMR spectroscopy and molecular modeling – the beginning of a wonderful friendship	3
Translation termination in human mitochondria – substrate specificity of mitochondrial release factors	3
Broadened substrate specificity of bacterial dipeptidyl-peptidase 7 enables release of half of all dipeptide combinations from peptide N-termini	3
Structure, function, and recombinant production of EGFL7	3
A biochemical view on the septins, a less known component of the cytoskeleton	3
Interactions of Na+/taurocholate cotransporting polypeptide with host cellular proteins upon hepatitis B and D virus infection: novel potential targets for antiviral therapy	3
Identification of cytokeratin24 as a tumor suppressor for the management of head and neck cancer	3
Small-molecule metabolites in SARS-CoV-2 treatment: a comprehensive review	3
Stoichiometry and architecture of the platelet membrane complex glycoprotein Ib-IX-V	3
Asymmetric horseshoe-like assembly of peroxisomal yeast oxalyl-CoA synthetase	3