Clinical Chemistry and Laboratory Medicine

Article	Citations
Performance of the 2009 CKDEPI, 2021 CKDEPI, and EKFC equations among high-risk patients in Denmark	107
Plenary 4 - Diagnostic advances in dementia	103
Analytical performance specifications for trace elements in biological fluids derived from six countries federated external quality assessment schemes over 10 years	100
Coagulation parameters in the newborn and infant – the Copenhagen Baby Heart and COMPARE studies	94
Acetylcholine receptor and muscle-specific tyrosine kinase antibodies detection: is it time for a change?	73
Behind the scenes of EQA – characteristics, capabilities, benefits and assets of external quality assessment (EQA): Part II – EQA cycles	73
COVID-19	61
Development of a liquid chromatography mass spectrometry method for the determination of vitamin K1, menaquinone-4, menaquinone-7 and vitamin K1-2,3 epoxide in serum of individuals without vitamin K s	60
EN ISO 15189 revision: EFLM Committee Accreditation and ISO/CEN standards (C: A/ISO) analysis and general remarks on the changes	55
From assessment to action: experience from a quality improvement initiative integrating indicator evaluation and adverse event analysis in a clinical laboratory	50
Machine learning-based delta check method for detecting misidentification errors in tumor marker tests	48
Design of an algorithm for the detection of intravenous fluid contamination in clinical laboratory samples	48
Quantification of blood glial fibrillary acidic protein using a second-generation microfluidic assay. Validation and comparative analysis with two established assays	45
Interference of therapeutic monoclonal antibodies with electrophoresis and immunofixation of serum proteins: state of knowledge and systematic review	42
Insight into the status of plasma renin and aldosterone measurement: findings from 526 clinical laboratories in China	41
Statistics in diagnostic medicine	41
Moving average quality control of routine chemistry and hematology parameters – a toolbox for implementation	41
7th EFLM Conference on Preanalytical Phase	41
Not all biases are created equal: how to deal with bias on laboratory measurements	40
Web-accessible critical limits and critical values for urgent clinician notification	40
A novel LC-MS/MS-based assay for the simultaneous quantification of aldosterone-related steroids in human urine	39
Discriminating signal from noise: the biological variation of circulating calprotectin in serum and plasma	38
Analytical interference of intravascular contrast agents with clinical laboratory tests: a joint guideline by the ESUR Contrast Media Safety Committee and the Preanalytical Phase Working Group of the	38
Multiplex proteomics using proximity extension assay for the identification of protein biomarkers predictive of acute graft-vs.-host disease in allogeneic hematopoietic cell transplantation	37
SYMPOSIUM 7 - Medical test standardization in the era of Metrological Traceability: who is accountable?	36

Overcoming challenges regarding reference materials and regulations that influence global standardization of medical laboratory testing results	36
Serial measurement of circulating calprotectin as a prognostic biomarker in COVID-19 patients in intensive care setting	36
ROUND-TABLE 1 - Beyond the Numbers: Integrating Laboratory and Clinical Perspectives on Thyroid Health	34
Diagnostic performance of a point of care high-sensitivity cardiac troponin I assay and single measurement evaluation to rule out and rule in acute coronary syndrome	31
Presence of SARS-CoV-2 RNA in COVID-19 survivors with post-COVID symptoms: a systematic review of the literature	31
Evaluation of the analytical and clinical performance of a new high-sensitivity cardiac troponin I assay: hs-cTnI (CLIA) assay	31
Frontmatter	31
Cell population data: much more to explore	30
An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for the quantification of aldosterone in human serum and plasma	30
An automatic chemiluminescence immunoassay for a novel biomarker NT-IGFBP-4: analytical performance and clinical relevance in heart failure	30
Multicenter study to compare the diagnostic performance of CLIA vs. FEIA transglutaminase IgA assays for the diagnosis of celiac disease	30
Diagnostic performance of machine learning models using cell population data for the detection of sepsis: a comparative study	29
Small-scale external quality assessment of methylated SHOX2 and RASSF1A detection in China: findings from	29
Monocyte distribution width (MDW) as a screening tool for early detecting sepsis: a systematic review and meta-analysis	28
Preanalytical quality improvement – an interdisciplinary journey	28
Epigenetic signatures of cfDNA enable a topological assignment of tissue damage	27
Measurement uncertainty estimation of free drug concentrations in clinical laboratories using equilibrium dialysis	27
Results of a SARS-CoV-2 virus genome detection external quality assessment round focusing on sensitivity of assays and pooling of samples	27
Frontmatter	26
Emerging technology: a definition for laboratory medicine	25
Stability of plasma renin concentration based on plasma freezing time, as an adjunct to the stability data reported in the paper by Hepburn and others	25
International collaborative study to evaluate and calibrate two recombinant L chain Ferritin preparations for use as a WHO International Standard	25
Evaluation of biochemical algorithms to screen dysbetalipoproteinemia in ε2ε2 and rare APOE variants carriers	25
Colorimetric correcting for sample concentration in stool samples	25
Familial dysalbuminemic hyperthyroxinemia coexisting with a Grave’s disease: a Belgian case report	25
Use of the term “Bence-Jones proteinuria” in the EFLM European Urinalysis Guideline 2023	25
Pseudohyperglycemia due to glucometer interference in galactosemia	25
Benchmarking medical laboratory performance: survey validation and results for Europe, Middle East, and Africa	25
HTA model for laboratory medicine technologies: overview of approaches adopted in some international agencies	25
Long-term effects of interventions applied to optimize the use of 25-OH vitamin D tests in primary health care	25
Analytical evaluation of the novel Mindray high sensitivity cardiac troponin I immunoassay on CL-1200i	24
Linearity assessment: deviation from linearity and residual of linear regression approaches	24
Refining within-subject biological variation estimation using routine laboratory data: practical applications of the refineR algorithm	24
Biological matrices, reagents and turnaround-time: the full-circle of artificial intelligence in the pre-analytical Phase. Comment on Turcic A, et al., Machine learning to optimize cerebrospinal fluid	22
IgG and kappa free light chain CSF/serum indices: evaluating intrathecal immunoglobulin production in HIV infection in comparison with multiple sclerosis	22
Contents	22
Concordance between the updated Elecsys cerebrospinal fluid immunoassays and amyloid positron emission tomography for Alzheimer’s disease assessment: findings from the Apollo study	22
One fits all: a highly sensitive combined ddPCR/pyrosequencing system for the quantification of microchimerism after hematopoietic and solid organ transplantation	22
SYMPOSIUM 1 - New approaches for deriving and applying biological variation data for clinical use	22
A single dose of 20-mg of ostarine is detectable in hair	22
The impact of COVID-19 on citations of laboratory medicine journals	22
Kidney diseases and transplantation, urinanalysis	21
ISMD2024 Thirteenth International Symposium on Molecular Diagnostics	21
Biological variation of serum cholinesterase activity in healthy subjects	21
The 10+1 Santorini Conference	21
Frontmatter	21
Laboratory response to paradigm change in hemophilia treatment	21
Precision Medicine	21
Cell population data for early detection of sepsis in patients with suspected infection in the emergency department	21
Biomarkers to measure the need and the effectiveness of therapeutic supplementation: a critical issue	21

Greater expectations: meeting clinical needs through broad and rapid genomic testing	20
External quality assurance (EQA): navigating between quality and sustainability	20
Dynamics of the vitamin D C3-epimer levels in preterm infants	20
Analytical performance specifications – moving from models to practical recommendations	20
An isotope dilution-liquid chromatography-tandem mass spectrometry based candidate reference measurement procedure for the simultaneous quantification of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2	19
Evaluation of effects from hemoglobin variants on HbA1c measurements by different methods	19
Drainage fluid LDH and neutrophil to lymphocyte ratio as biomarkers for early detecting anastomotic leakage in patients undergoing colorectal surgery	19
Comparison of near-infrared and UV–vis-based non-contact hematocrit prediction of dried blood spots from patients on immunosuppressants	19
Clinical evidence requirements according to the IVDR 2017/746: practical tools and references for underpinning clinical evidence of IVD-MDs	19
Clinical utility of personalized reference intervals for CEA in the early detection of oncologic disease	18
Pseudo-erythroblastosis on Sysmex XN hematology analyzers: a clue to Candida sepsis. Case report and literature review	18
Artificial intelligence in clinical applications for lung cancer: diagnosis, treatment and prognosis	18
Response to Tony Badrick regarding “Letter to the Editor regarding the article by Wayne J. Dimech et al. Time to address quality control processes applied to antibody testing for infectious diseases.	18
Neonatal reference intervals for serum steroid hormone concentrations measured by LC-MS/MS	18
The role of analytical performance specifications in international guidelines and standards dealing with metrological traceability in laboratory medicine	18
Regulating the future of laboratory medicine: European regulatory landscape of AI-driven medical device software in laboratory medicine	18
IgA rheumatoid factor in rheumatoid arthritis	18
Comparison between polynomial regression and weighted least squares regression analysis for verification of analytical measurement range	17
Diabetes, obesity, metabolic syndrome	17
Quality in laboratory medicine and the Journal: walking together	17
Comprehensive evaluation of antiphospholipid antibody testing methodologies in APS diagnosis: performance comparisons across assay systems and clinical subtypes	17
Evaluation of the interchangeability between the new fully-automated affinity chrome-mediated immunoassay (ACMIA) and the Quantitative Microsphere System (QMS) with a CE-IVD-certified LC-MS/MS assay f	17
Metrological traceability and test standardization/harmonization	17
Remote monitoring and preanalytical challenges	17
An improved implementation of metrological traceability concepts is needed to benefit from standardization of laboratory results	17
What Matters Most: an Age-Friendly approach to pathology and laboratory medicine	17
Frontmatter	17
Lot-to-lot reagent verification: challenges and possible solutions	17
A step forward in pediatric hemophagocytic lymphohistiocytosis and autoimmune disease: pediatric reference interval for serum soluble IL-2 receptor and soluble CD163	17
Serum sPD-L1 levels are elevated in patients with viral diseases, bacterial sepsis or in patients with impaired renal function compared to healthy blood donors	17
Clinical evaluation of the OC-Sensor Pledia calprotectin assay	16
Estimation of the reference values and decision limits for growth hormone in newborns using dried blood spots	16
Annual meeting of the Royal Belgian Society of Laboratory Medicine: “Symphony of the Heart”	16
Quality indicators: an evolving target for laboratory medicine	16
The preanalytical process in the emergency department, a European survey	16
Performance evaluation and user experience of BT-50 transportation unit with automated and scheduled quality control measurements	16
Frontmatter	16
Is it feasible for European laboratories to use SI units in reporting results?	16
Serous body fluid evaluation using the new automated haematology analyser Mindray BC-6800Plus	16
A new milestone on the road to global standardization of apolipoprotein measurements	16
Association of prehospital lactate levels with base excess in various emergencies – a retrospective study	16
Urine transfer devices may impact urinary particle results: a pre-analytical study	16
Reply to: “Accurate predictory role of monocyte distribution width on short-term outcome in sepsis patients”	16
A randomized controlled study of biochemical tests in primary care: interventions can reduce the number of tests but usage does not become more appropriate	15
Accurate stratification between VEXAS syndrome and differential diagnoses by deep learning analysis of peripheral blood smears	15
Differences between high-sensitivity cardiac troponin T and I in stable populations: underlying causes and clinical implications	15
An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure for the quantification of carbamazepine-10,11-epoxide in human serum an	15
Assessment of the humoral response in Omicron breakthrough cases in healthcare workers who received the BNT162b2 booster	15
Improving regional medical laboratory center report quality through a report recall management system	15
Comparison of three different protocols for obtaining hemolysis	15
Limitations of glycated albumin standardization when applied to the assessment of diabetes patients	15
The biological variation of insulin resistance markers: data from the European Biological Variation Study (EuBIVAS)	15
The role of Killer immunoglobulin-like receptors (KIRs) in the genetic susceptibility to non-celiac wheat sensitivity (NCWS)	15
Flow-cytometric lymphocyte subsets enumeration: comparison of single/dual-platform method in clinical laboratory with dual-platform extended PanLeucogating method in reference laboratory	15
Understanding the limitations of your assay using EQA data with serum creatinine as an example	15
A physio-chemical mathematical model of the effects of blood analysis delay on acid-base, metabolite and electrolyte status: evaluation in blood from critical care patients	15
Copeptin as a diagnostic and prognostic biomarker in pediatric diseases	15
Assessing the clinical applicability of dimensionality reduction algorithms in flow cytometry for hematologic malignancies	15
Influence of remnant cholesterol on direct LDL and HDL cholesterol measurement accuracy	15
‘Penelope test’: a practical instrument for checking appropriateness of laboratory tests	15
Assessing the harmonization of current total vitamin B12 measurement methods: relevance and implications	14
Validation and verification framework and data integration of biosensors and in vitro diagnostic devices: a position statement of the IFCC Committee on Mobile Health and Bioengineering in Labor	14
Variations in tumor growth, intra-individual biological variability, and the interpretation of changes	14
Six years of progress – highlights from the IFCC Emerging Technologies Division	14
In-house diagnostic devices under the EU IVDR and unwanted side-effects of intentional transparency	14
Acknowledgment	14
Testosterone analysis in castrated prostate cancer patients: suitability of the castration cut-off and analytical accuracy of the present-day clinical immunoassays	14
Unraveling the mystery of blood groups and COVID-19	14
The first case of Teclistamab interference with serum electrophoresis and immunofixation	14
New concept of interactive academic poster used in medical scientific congress presented in the EuroMedLab 2021 Munich Session	14
Spike vs. nucleocapsid serum antigens for COVID-19 diagnosis and severity assessment	14
Estimation of the allowable total error of the absolute CD34+ cell count by flow cytometry using data from UK NEQAS exercises 2004–2024	13
Kinetics and ability of binding antibody and surrogate virus neutralization tests to predict neutralizing antibodies against the SARS-CoV-2 Omicron variant following BNT162b2 booster administration	13
Diagnosis of IRAK-4-deficiency by flow cytometric measurement of IκB-α degradation	13
Rare unstable and low oxygen affinity haemoglobin variant, Hb Hazebrouck, detected on Sysmex XN-9000	13
Chemical strategies for sustainable medical laboratories	13
Preanalytical phase	13
Clostebol detection after transdermal and transmucosal contact. A systematic review	13
Improved implementation of medical tests – barriers and opportunities	13
The routine coagulation assays plasma stability – in the wake of the new European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) biological variability database	13

Artificial intelligence, clinical decision support and machine learning	13
Transport stability profiling – a proposed generic protocol	13
Striving for a pragmatic contribution of biomarkers results to lifelong health care	13
Where is laboratory medicine headed in the next decade? Partnership model for efficient integration and adoption of artificial intelligence into medical laboratories	13
Early autoimmune signature in a young woman: palmar erythema, capillaroscopic abnormalities, and triple autoantibody positivity including anti-nucleosome	13
S100B in cardiac surgery brain monitoring: friend or foe?	13
Novel protocol for metabolomics data normalization and biomarker discovery in human tears	13
Setting analytical performance specifications for copeptin-based testing	13
Nutrition Trace Elements and Vitamins	13
An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of cortisol in human urine	13
Clinical implication by differential analytical performances of serum free light chain quantitation analysis using fully automated analyzers	13
Ct values of different SARS CoV2 variants: a single center observational study from Innsbruck, Austria	13
Tafasitamab interference in immunofixation electrophoresis	13
Inconsistency in ferritin reference intervals across laboratories: a major concern for clinical decision making	12
Histamine metabolite to basal serum tryptase ratios in systemic mastocytosis and hereditary alpha tryptasemia using a validated LC-MS/MS approach	12
Performance evaluation of the introduction of full sample traceability system within the specimen collection process	12
Comparison between free β subunit of human chorionic gonadotropin (hCG) and total hCG assays in adults with testicular cancer	12
An approach for determining allowable between reagent lot variation	12
Reference intervals of circulating secretoneurin concentrations determined in a large cohort of community dwellers: the HUNT study	12
Biological variation of serum Golgi protein 73 concentrations	12
Arivale is dead ‒ Hooke is alive	12
Evidence-based procedures to improve the reliability of circulating miRNA biomarker assays	12
Performance of GFAP and UCH-L1 compared to S100B in detecting intracranial injury: influence of age, hemolysis, neurodegenerative diseases, and extracranial fractures in a prospective cohort of over 1	12
A survey on Artificial Intelligence and Big Data utilisation in Italian clinical laboratories	12
SARS CoV-2 spike protein-guided exosome isolation facilitates detection of potential miRNA biomarkers in COVID-19 infections	12
Diagnostic accuracy of extended HPV DNA genotyping and its application for risk-based cervical cancer screening strategy	12
Precise glucose measurement in sodium fluoride-citrate plasma affects estimates of prevalence in diabetes and prediabetes	12
A model for managing quality control for a network of clinical chemistry instruments measuring the same analyte	12
Evidence for stability of cardiac troponin T concentrations measured with a high sensitivity TnT test in serum and lithium heparin plasma after six-year storage at −80 °C and multiple freeze-thaw cycl	12
Positivization time of a COVID-19 rapid antigen self-test predicts SARS-CoV-2 viral load: a proof of concept	11
Biological variation of serum iron from the European biological variation study (EuBIVAS)	11
Is uracil enough for effective pre-emptive DPD testing?	11
The total testing process harmonization: the case study of SARS-CoV-2 serological tests	11
Symposium 13 - Prenatal testing	11
Interferences in immunoassays: review and practical algorithm	11
Sepsis	11
Macroprolactinaemia – some progress but still an ongoing problem	11
Analytical and clinical evaluations of Snibe Maglumi® S100B assay	11
First-trimester screening for Down syndrome using quadruple maternal biochemical markers	11
Searching for the urine osmolality surrogate: an automated machine learning approach	11
C-terminal alpha-1-antitrypsin peptides as novel predictor of hospital mortality in critically ill COVID-19 patients	11
Review and evolution of guidelines for diagnosis of COVID-19 vaccine induced thrombotic thrombocytopenia (VITT)	11
Tumor markers determination in malignant pleural effusion: pearls and pitfalls	11
Diagnostic performance of Mindray CL1200i high sensitivity cardiac troponin I assay compared to Abbott Alinity cardiac troponin I assay for the diagnosis of type 1 and 2 acute myocardial infarction in	11
Using artificial intelligence in a primary care setting to identify patients at risk for cancer: a risk prediction model based on routine laboratory tests	11
An appeal for biological variation estimates in deep immunophenotyping	11
Spurious parathyroid hormone (PTH) elevation caused by macro-PTH	11
Can we identify patients carrying targeted deleterious DPYD variants with plasma uracil and dihydrouracil? A GPCO-RNPGx retrospective analysis	11
The effects of drone transportation on routine laboratory, immunohematology, flow cytometry and molecular analyses	11
Diagnostic accuracy of adenosine deaminase for tuberculous pleural effusion: age does matter	11
Frontmatter	11
Patient risk management in laboratory medicine: an international survey to assess the severity of harm associated with erroneous reported results	11
16ª Reunião Científica da Sociedade Portuguesa de Medicina Laboratorial - SPML	11
Use of high-sensitivity cardiac troponins in the emergency department for the early rule-in and rule-out of acute myocardial infarction without persistent ST-segment elevation (NSTEMI) in Italy	11
The journey to pre-analytical quality	10
Immunology	10
Association of circulating free and total oxysterols in breast cancer patients	10
Commercial immunoassays for detection of anti-SARS-CoV-2 spike and RBD antibodies: urgent call for validation against new and highly mutated variants	10
Early changes in S100B maternal blood levels can predict fetal intrauterine growth restriction	10
Validation of (self-collected) capillary blood using a topper collection system as alternative for venous sampling for 15 common clinical chemistry analytes	10
Evaluating the performance of a multiparametric IgA assay for celiac disease diagnosis	10
Method comparison of three serum free light chain assays on the Roche Cobas 6000 c501 chemistry analyzer	10
Analytical performance specifications based on biological variation data – considerations, strengths and limitations	10
Interference with immunofixation in a dabigatran-overdosed patient treated with idarucizumab: beware of a diagnostic pitfall	10
Impact of different preservation methods on urinary red blood cell counts	10
Standardization challenges in antipsychotic drug monitoring: insights from a national survey in Chinese TDM practices	10
Correction of negative-interference from calcium dobesilate in the Roche sarcosine oxidase creatinine assay using CuO	10
The simple reproducibility of a measurement result does not equal its overall measurement uncertainty	10
A novel immunoprecipitation-based targeted liquid chromatography-tandem mass spectrometry analysis for accurate determination for copeptin in human serum	10
An overview of the most important preanalytical factors influencing the clinical performance of SARS-CoV-2 antigen rapid diagnostic tests (Ag-RDTs)	10
Toxicology and TDM	10
Traceable machine learning real-time quality control based on patient data	10
M-protein diagnostics in multiple myeloma patients using ultra-sensitive targeted mass spectrometry and an off-the-shelf calibrator	10
IFCC Symposium - Advancing Excellence in Laboratory Medicine Worldwide: An Update from IFCC Taskforces	10
Tutorial: statistical methods for the meta-analysis of diagnostic test accuracy studies	10
Serum biomarkers of remodeling in severe asthma with fixed airway obstruction and the potential role of KL-6	10
Clearance of macro-TSH from the circulation is slower than TSH	10
Early rule-out high-sensitivity troponin protocols require continuous analytical robustness: a caution regarding the potential for troponin assay down-calibration	9
Added value of drug-laboratory test interaction alerts in test result authorisation	9
Counting cells is not enough: toward a global vision for quality and training in hematology	9
Point-of-care testing: state-of-the art and perspectives	9
Necessity of harmonization of tissue transglutaminase IgA assays to align clinical decision making in coeliac disease	9
Evaluation of the Atellica TnIH cardiac troponin I assay and assessment of biological equivalence	9
False-positive cardiac troponin I values due to macrotroponin in healthy athletes after COVID-19	9
Serum free light chain analysis: persisting limitations with new kids on the block	9
Lack of comparability of immunoassays for rheumatoid factor isotypes	9
Evolution of autoimmune diagnostics over the past 10 years: lessons learned from the UK NEQAS external quality assessment EQA programs	9
Two cases of MTHFR C677T polymorphism typing failure by Taqman system due to MTHFR 679 GA heterozygous mutation	9
Allowable total error in CD34 cell analysis by flow cytometry based on state of the art using Spanish EQAS data	9
Frontmatter	9
Reconciling reference ranges and clinical decision limits: the case of thyroid stimulating hormone	9
Harmonization of indirect reference intervals calculation by the Bhattacharya method	9
Laboratory medicine unveiling an unusual cause of D-lactic acidosis as the trigger of decompensation of a rare inborn error of metabolism	9
Fifty years of newborn screening for congenital hypothyroidism: current status in Australasia and the case for harmonisation	9
Prognostic significance of blood-based multi-cancer detection in plasma cell-free DNA	9