Clinical Chemistry and Laboratory Medicine

Article	Citations
Machine learning-based delta check method for detecting misidentification errors in tumor marker tests	88
Performance of the 2009 CKDEPI, 2021 CKDEPI, and EKFC equations among high-risk patients in Denmark	84
Coagulation parameters in the newborn and infant – the Copenhagen Baby Heart and COMPARE studies	79
Plenary 4 - Diagnostic advances in dementia	73
COVID-19	69
Analytical performance specifications for trace elements in biological fluids derived from six countries federated external quality assessment schemes over 10 years	58
Quantification of blood glial fibrillary acidic protein using a second-generation microfluidic assay. Validation and comparative analysis with two established assays	52
Web-accessible critical limits and critical values for urgent clinician notification	50
Development of a liquid chromatography mass spectrometry method for the determination of vitamin K1, menaquinone-4, menaquinone-7 and vitamin K1-2,3 epoxide in serum of individuals without vitamin K s	47
Overcoming challenges regarding reference materials and regulations that influence global standardization of medical laboratory testing results	45
EN ISO 15189 revision: EFLM Committee Accreditation and ISO/CEN standards (C: A/ISO) analysis and general remarks on the changes	43
Quantitative profiling of inflammatory and pro-resolving lipid mediators in human adolescents and mouse plasma using UHPLC-MS/MS	42
Frontmatter	41
SYMPOSIUM 7 - Medical test standardization in the era of Metrological Traceability: who is accountable?	40
Insight into the status of plasma renin and aldosterone measurement: findings from 526 clinical laboratories in China	37
ROUND-TABLE 1 - Beyond the Numbers: Integrating Laboratory and Clinical Perspectives on Thyroid Health	37
Measurement uncertainty estimation of free drug concentrations in clinical laboratories using equilibrium dialysis	35
Discriminating signal from noise: the biological variation of circulating calprotectin in serum and plasma	35
Presence of SARS-CoV-2 RNA in COVID-19 survivors with post-COVID symptoms: a systematic review of the literature	34
Analytical interference of intravascular contrast agents with clinical laboratory tests: a joint guideline by the ESUR Contrast Media Safety Committee and the Preanalytical Phase Working Group of the	34
Diagnostic performance of a point of care high-sensitivity cardiac troponin I assay and single measurement evaluation to rule out and rule in acute coronary syndrome	34
Statistics in diagnostic medicine	33
Moving average quality control of routine chemistry and hematology parameters – a toolbox for implementation	31
Multiplex proteomics using proximity extension assay for the identification of protein biomarkers predictive of acute graft-vs.-host disease in allogeneic hematopoietic cell transplantation	31
Design of an algorithm for the detection of intravenous fluid contamination in clinical laboratory samples	31

Diagnostic performance of machine learning models using cell population data for the detection of sepsis: a comparative study	31
Acetylcholine receptor and muscle-specific tyrosine kinase antibodies detection: is it time for a change?	31
Serial measurement of circulating calprotectin as a prognostic biomarker in COVID-19 patients in intensive care setting	31
Monocyte distribution width (MDW) as a screening tool for early detecting sepsis: a systematic review and meta-analysis	31
A novel LC-MS/MS-based assay for the simultaneous quantification of aldosterone-related steroids in human urine	29
Preanalytical quality improvement – an interdisciplinary journey	29
Evaluation of the analytical and clinical performance of a new high-sensitivity cardiac troponin I assay: hs-cTnI (CLIA) assay	28
Results of a SARS-CoV-2 virus genome detection external quality assessment round focusing on sensitivity of assays and pooling of samples	28
Behind the scenes of EQA – characteristics, capabilities, benefits and assets of external quality assessment (EQA): Part II – EQA cycles	28
Not all biases are created equal: how to deal with bias on laboratory measurements	27
Multicenter study to compare the diagnostic performance of CLIA vs. FEIA transglutaminase IgA assays for the diagnosis of celiac disease	26
Cell population data: much more to explore	26
Frontmatter	25
An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for the quantification of aldosterone in human serum and plasma	25
Reference intervals and decision limits	24
Evaluation of biochemical algorithms to screen dysbetalipoproteinemia in ε2ε2 and rare APOE variants carriers	24
Frontmatter	24
Epigenetic signatures of cfDNA enable a topological assignment of tissue damage	24
53rd National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC – Laboratory Medicine)	23
Precision Medicine	23
Biological matrices, reagents and turnaround-time: the full-circle of artificial intelligence in the pre-analytical Phase. Comment on Turcic A, et al., Machine learning to optimize cerebrospinal fluid	23
ISMD2024 Thirteenth International Symposium on Molecular Diagnostics	23
Kidney diseases and transplantation, urinanalysis	23
The 10+1 Santorini Conference	23
Clinical Studies - Outcomes	22
Laboratory response to paradigm change in hemophilia treatment	22
Comparison of near-infrared and UV–vis-based non-contact hematocrit prediction of dried blood spots from patients on immunosuppressants	21
Frontmatter	21
Neonatal reference intervals for serum steroid hormone concentrations measured by LC-MS/MS	21
The impact of COVID-19 on citations of laboratory medicine journals	21
Greater expectations: meeting clinical needs through broad and rapid genomic testing	21
Procalcitonin measured by three different assays is an excellent tumor marker for the follow-up of patients with medullary thyroid carcinoma	21
Clinical utility of personalized reference intervals for CEA in the early detection of oncologic disease	21
Response to Tony Badrick regarding “Letter to the Editor regarding the article by Wayne J. Dimech et al. Time to address quality control processes applied to antibody testing for infectious diseases.	20
Emerging technology: a definition for laboratory medicine	20
Clinical evidence requirements according to the IVDR 2017/746: practical tools and references for underpinning clinical evidence of IVD-MDs	20
Serum sPD-L1 levels are elevated in patients with viral diseases, bacterial sepsis or in patients with impaired renal function compared to healthy blood donors	20
NT-proBNP use in old patients and the impact of the selected threshold value: a big data analysis	20
One fits all: a highly sensitive combined ddPCR/pyrosequencing system for the quantification of microchimerism after hematopoietic and solid organ transplantation	20
Stability of plasma renin concentration based on plasma freezing time, as an adjunct to the stability data reported in the paper by Hepburn and others	20
Pseudo-erythroblastosis on Sysmex XN hematology analyzers: a clue to Candida sepsis. Case report and literature review	20
Pseudohyperglycemia due to glucometer interference in galactosemia	19
External quality assurance (EQA): navigating between quality and sustainability	19
International collaborative study to evaluate and calibrate two recombinant L chain Ferritin preparations for use as a WHO International Standard	19
Linearity assessment: deviation from linearity and residual of linear regression approaches	19
Familial dysalbuminemic hyperthyroxinemia coexisting with a Grave’s disease: a Belgian case report	19
HTA model for laboratory medicine technologies: overview of approaches adopted in some international agencies	19
Refining within-subject biological variation estimation using routine laboratory data: practical applications of the refineR algorithm	19
Use of the term “Bence-Jones proteinuria” in the EFLM European Urinalysis Guideline 2023	19
Long-term effects of interventions applied to optimize the use of 25-OH vitamin D tests in primary health care	19

Contents	19
Drainage fluid LDH and neutrophil to lymphocyte ratio as biomarkers for early detecting anastomotic leakage in patients undergoing colorectal surgery	18
IgG and kappa free light chain CSF/serum indices: evaluating intrathecal immunoglobulin production in HIV infection in comparison with multiple sclerosis	18
Biological variation of serum cholinesterase activity in healthy subjects	18
Quality in laboratory medicine and the Journal: walking together	18
Microbiology - Infectious diseases including COVID 19	18
An improved implementation of metrological traceability concepts is needed to benefit from standardization of laboratory results	18
Analytical evaluation of the novel Mindray high sensitivity cardiac troponin I immunoassay on CL-1200i	18
Analytical performance specifications – moving from models to practical recommendations	18
The role of analytical performance specifications in international guidelines and standards dealing with metrological traceability in laboratory medicine	18
SYMPOSIUM 1 - New approaches for deriving and applying biological variation data for clinical use	18
Dynamics of the vitamin D C3-epimer levels in preterm infants	18
Cell population data for early detection of sepsis in patients with suspected infection in the emergency department	18
Colorimetric correcting for sample concentration in stool samples	18
Concordance between the updated Elecsys cerebrospinal fluid immunoassays and amyloid positron emission tomography for Alzheimer’s disease assessment: findings from the Apollo study	17
Regulating the future of laboratory medicine: European regulatory landscape of AI-driven medical device software in laboratory medicine	17
Artificial intelligence in clinical applications for lung cancer: diagnosis, treatment and prognosis	17
Biomarkers to measure the need and the effectiveness of therapeutic supplementation: a critical issue	17
IgA rheumatoid factor in rheumatoid arthritis	17
Benchmarking medical laboratory performance: survey validation and results for Europe, Middle East, and Africa	17
Lot-to-lot reagent verification: challenges and possible solutions	16
Diabetes, obesity, metabolic syndrome	16
Remote monitoring and preanalytical challenges	16
Comparison of three different protocols for obtaining hemolysis	16
Evaluation of reference intervals for classical and alternative pathway functional complement assays	16
Inherited disorders, metabolic disorders and rare diseases	16
Frontmatter	16
A new milestone on the road to global standardization of apolipoprotein measurements	16
A randomized controlled study of biochemical tests in primary care: interventions can reduce the number of tests but usage does not become more appropriate	16
‘Penelope test’: a practical instrument for checking appropriateness of laboratory tests	16
Evaluation of effects from hemoglobin variants on HbA1c measurements by different methods	16
Lot variation and inter-device differences contribute to poor analytical performance of the DCA Vantage™ HbA1c POCT instrument in a true clinical setting	16
Metrological traceability and test standardization/harmonization	16
Performance evaluation and user experience of BT-50 transportation unit with automated and scheduled quality control measurements	15
Assessment of the humoral response in Omicron breakthrough cases in healthcare workers who received the BNT162b2 booster	15
Evaluation of the interchangeability between the new fully-automated affinity chrome-mediated immunoassay (ACMIA) and the Quantitative Microsphere System (QMS) with a CE-IVD-certified LC-MS/MS assay f	15
The role of Killer immunoglobulin-like receptors (KIRs) in the genetic susceptibility to non-celiac wheat sensitivity (NCWS)	15
Reply to: “Accurate predictory role of monocyte distribution width on short-term outcome in sepsis patients”	15
Serous body fluid evaluation using the new automated haematology analyser Mindray BC-6800Plus	15
Urine transfer devices may impact urinary particle results: a pre-analytical study	15
Association of prehospital lactate levels with base excess in various emergencies – a retrospective study	15
Understanding the limitations of your assay using EQA data with serum creatinine as an example	15
Comparison between polynomial regression and weighted least squares regression analysis for verification of analytical measurement range	15
Clinical evaluation of the OC-Sensor Pledia calprotectin assay	15
The preanalytical process in the emergency department, a European survey	15
Copeptin as a diagnostic and prognostic biomarker in pediatric diseases	14
An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure for the quantification of carbamazepine-10,11-epoxide in human serum an	14
A physio-chemical mathematical model of the effects of blood analysis delay on acid-base, metabolite and electrolyte status: evaluation in blood from critical care patients	14
Comparison of the analytical performance of the PATHFAST high sensitivity cardiac troponin I using fresh whole blood vs. fresh plasma samples	14
The biological variation of insulin resistance markers: data from the European Biological Variation Study (EuBIVAS)	14
Artificial intelligence - Informatics	14
Frontmatter	14
Annual meeting of the Royal Belgian Society of Laboratory Medicine: “Symphony of the Heart”	14
Estimation of the reference values and decision limits for growth hormone in newborns using dried blood spots	14
Frontmatter	14
Improving regional medical laboratory center report quality through a report recall management system	14
Is it feasible for European laboratories to use SI units in reporting results?	13
The first case of Teclistamab interference with serum electrophoresis and immunofixation	13
Haematology, including haemostasis	13
Unraveling the mystery of blood groups and COVID-19	13
In-house diagnostic devices under the EU IVDR and unwanted side-effects of intentional transparency	13
Assessing the clinical applicability of dimensionality reduction algorithms in flow cytometry for hematologic malignancies	13
Accurate stratification between VEXAS syndrome and differential diagnoses by deep learning analysis of peripheral blood smears	13
Kidney diseases	13
Diagnostic accuracy of extended HPV DNA genotyping and its application for risk-based cervical cancer screening strategy	13
Validation and verification framework and data integration of biosensors and in vitro diagnostic devices: a position statement of the IFCC Committee on Mobile Health and Bioengineering in Labor	13
Flow-cytometric lymphocyte subsets enumeration: comparison of single/dual-platform method in clinical laboratory with dual-platform extended PanLeucogating method in reference laboratory	13
Acknowledgment	13
New concept of interactive academic poster used in medical scientific congress presented in the EuroMedLab 2021 Munich Session	13
Limitations of glycated albumin standardization when applied to the assessment of diabetes patients	13
Differences between high-sensitivity cardiac troponin T and I in stable populations: underlying causes and clinical implications	13
Nutrition Trace Elements and Vitamins	12
S100B in cardiac surgery brain monitoring: friend or foe?	12
Variations in tumor growth, intra-individual biological variability, and the interpretation of changes	12
Diagnosis of IRAK-4-deficiency by flow cytometric measurement of IκB-α degradation	12
Evidence-based procedures to improve the reliability of circulating miRNA biomarker assays	12
Interferences in immunoassays: review and practical algorithm	12
Transport stability profiling – a proposed generic protocol	12
Review and evolution of guidelines for diagnosis of COVID-19 vaccine induced thrombotic thrombocytopenia (VITT)	12
Rare unstable and low oxygen affinity haemoglobin variant, Hb Hazebrouck, detected on Sysmex XN-9000	12

Artificial intelligence, clinical decision support and machine learning	12
Inconsistency in ferritin reference intervals across laboratories: a major concern for clinical decision making	12
Clinical implication by differential analytical performances of serum free light chain quantitation analysis using fully automated analyzers	12
Tumor markers determination in malignant pleural effusion: pearls and pitfalls	12
Striving for a pragmatic contribution of biomarkers results to lifelong health care	12
Reference intervals of circulating secretoneurin concentrations determined in a large cohort of community dwellers: the HUNT study	12
Spike vs. nucleocapsid serum antigens for COVID-19 diagnosis and severity assessment	12
Low serum TSH in the acute phase of COVID-19 pneumonia: thyrotoxicosis or a face of “non-thyroidal illness syndrome”?	12
Kinetics and ability of binding antibody and surrogate virus neutralization tests to predict neutralizing antibodies against the SARS-CoV-2 Omicron variant following BNT162b2 booster administration	12
Improved implementation of medical tests – barriers and opportunities	12
Estimation of the allowable total error of the absolute CD34+ cell count by flow cytometry using data from UK NEQAS exercises 2004–2024	12
Precise glucose measurement in sodium fluoride-citrate plasma affects estimates of prevalence in diabetes and prediabetes	12
Setting analytical performance specifications for copeptin-based testing	12
Comparison between free β subunit of human chorionic gonadotropin (hCG) and total hCG assays in adults with testicular cancer	12
Ct values of different SARS CoV2 variants: a single center observational study from Innsbruck, Austria	12
Diagnostic accuracy of adenosine deaminase for tuberculous pleural effusion: age does matter	12
Six years of progress – highlights from the IFCC Emerging Technologies Division	12
Testosterone analysis in castrated prostate cancer patients: suitability of the castration cut-off and analytical accuracy of the present-day clinical immunoassays	12
Novel protocol for metabolomics data normalization and biomarker discovery in human tears	11
Neurological diseases	11
Sepsis	11
Evidence for stability of cardiac troponin T concentrations measured with a high sensitivity TnT test in serum and lithium heparin plasma after six-year storage at −80 °C and multiple freeze-thaw cycl	11
A model for managing quality control for a network of clinical chemistry instruments measuring the same analyte	11
Clostebol detection after transdermal and transmucosal contact. A systematic review	11
Histamine metabolite to basal serum tryptase ratios in systemic mastocytosis and hereditary alpha tryptasemia using a validated LC-MS/MS approach	11
Where is laboratory medicine headed in the next decade? Partnership model for efficient integration and adoption of artificial intelligence into medical laboratories	11
Symposium 13 - Prenatal testing	11
Performance evaluation of the introduction of full sample traceability system within the specimen collection process	11
A survey on Artificial Intelligence and Big Data utilisation in Italian clinical laboratories	11
The routine coagulation assays plasma stability – in the wake of the new European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) biological variability database	11
Chemical strategies for sustainable medical laboratories	11
Frontmatter	11
Arivale is dead ‒ Hooke is alive	11
Preanalytical phase	11
SARS CoV-2 spike protein-guided exosome isolation facilitates detection of potential miRNA biomarkers in COVID-19 infections	11
An approach for determining allowable between reagent lot variation	11
M-protein diagnostics in multiple myeloma patients using ultra-sensitive targeted mass spectrometry and an off-the-shelf calibrator	10
C-terminal alpha-1-antitrypsin peptides as novel predictor of hospital mortality in critically ill COVID-19 patients	10
A screening method to spot biomarkers that may warn of serious events in a chronic disease – illustrated by cardiological CLARICOR trial data	10
An appeal for biological variation estimates in deep immunophenotyping	10
Tutorial: statistical methods for the meta-analysis of diagnostic test accuracy studies	10
The simple reproducibility of a measurement result does not equal its overall measurement uncertainty	10
Impact of different preservation methods on urinary red blood cell counts	10
Method comparison of three serum free light chain assays on the Roche Cobas 6000 c501 chemistry analyzer	10
Association of circulating free and total oxysterols in breast cancer patients	10
Toxicology and TDM	10
The effects of drone transportation on routine laboratory, immunohematology, flow cytometry and molecular analyses	10
Laboratory Management, Accreditation, Quality Assurance, performance specification	10
Measuring accuracy of the neutralizing activity of COVID-19 convalescent plasma	10
Can we identify patients carrying targeted deleterious DPYD variants with plasma uracil and dihydrouracil? A GPCO-RNPGx retrospective analysis	10
Clearance of macro-TSH from the circulation is slower than TSH	10
Searching for the urine osmolality surrogate: an automated machine learning approach	10
Pre-analytical recommendations and reference values for circulating calprotectin are sample type and assay dependent	10
Is uracil enough for effective pre-emptive DPD testing?	10
Correction of negative-interference from calcium dobesilate in the Roche sarcosine oxidase creatinine assay using CuO	10
Traceable machine learning real-time quality control based on patient data	10
16ª Reunião Científica da Sociedade Portuguesa de Medicina Laboratorial - SPML	10
The total testing process harmonization: the case study of SARS-CoV-2 serological tests	10
Frontmatter	10
Biological variation of serum iron from the European biological variation study (EuBIVAS)	10
First-trimester screening for Down syndrome using quadruple maternal biochemical markers	10
Diagnostic performance of Mindray CL1200i high sensitivity cardiac troponin I assay compared to Abbott Alinity cardiac troponin I assay for the diagnosis of type 1 and 2 acute myocardial infarction in	10
Commercial immunoassays for detection of anti-SARS-CoV-2 spike and RBD antibodies: urgent call for validation against new and highly mutated variants	10
Using artificial intelligence in a primary care setting to identify patients at risk for cancer: a risk prediction model based on routine laboratory tests	10
Spurious parathyroid hormone (PTH) elevation caused by macro-PTH	10
Positivization time of a COVID-19 rapid antigen self-test predicts SARS-CoV-2 viral load: a proof of concept	10
Immunology	10
An overview of the most important preanalytical factors influencing the clinical performance of SARS-CoV-2 antigen rapid diagnostic tests (Ag-RDTs)	10
Ageing, ACE2 deficiency and bad outcome in COVID-19	9
Patient risk management in laboratory medicine: an international survey to assess the severity of harm associated with erroneous reported results	9
Analytical and clinical evaluations of Snibe Maglumi® S100B assay	9
Development of an inverse-PCR approach for characterization of the major BCR-ABL1 breakpoint sequences on genomic DNA: proof of concept	9
Endocrinology, not including diabetes	9
Reference intervals for high sensitivity cardiac troponin I and N-terminal pro-B-type natriuretic peptide in children and adolescents on the Siemens Atellica	9
Detection of urinary foam cells diagnosing the XGP with thrombopenia preoperatively: a case report	9
Frontmatter	9
An appraisal of the practice of duplicate testing for the detection of irregular analytical errors	9
Serum biomarkers of remodeling in severe asthma with fixed airway obstruction and the potential role of KL-6	9
Macroprolactinaemia – some progress but still an ongoing problem	9
Use of high-sensitivity cardiac troponins in the emergency department for the early rule-in and rule-out of acute myocardial infarction without persistent ST-segment elevation (NSTEMI) in Italy	9
IFCC Symposium - Advancing Excellence in Laboratory Medicine Worldwide: An Update from IFCC Taskforces	9
Evolution of autoimmune diagnostics over the past 10 years: lessons learned from the UK NEQAS external quality assessment EQA programs	9
Point of Care testing, critical care, emergency medicine	9
Reference values for plasma neurofilament light chain in healthy Chinese children	9
Added value of drug-laboratory test interaction alerts in test result authorisation	9
Diagnostic quality model (DQM): an integrated framework for the assessment of diagnostic quality when using AI/ML	9
The journey to pre-analytical quality	9
Standardization challenges in antipsychotic drug monitoring: insights from a national survey in Chinese TDM practices	9
Committees	9
Lot-to-lot bias for high-sensitivity cardiac troponin I concentrations ≥1000 ng/L	9
Two cases of MTHFR C677T polymorphism typing failure by Taqman system due to MTHFR 679 GA heterozygous mutation	9
Temporal biomarker concentration patterns during the early course of acute coronary syndrome	9
Impact of ultra-low temperature long-term storage on the preanalytical variability of twenty-one common biochemical analytes	9
Is this a true lambda free light chain?	9
External quality assessment of serum indices: Spanish SEQC-ML program	9