Clinical Chemistry and Laboratory Medicine

Article	Citations
Performance of the 2009 CKDEPI, 2021 CKDEPI, and EKFC equations among high-risk patients in Denmark	98
Plenary 4 - Diagnostic advances in dementia	87
COVID-19	85
Monocyte distribution width (MDW) as a screening tool for early detecting sepsis: a systematic review and meta-analysis	83
Analytical performance specifications for trace elements in biological fluids derived from six countries federated external quality assessment schemes over 10 years	73
Statistics in diagnostic medicine	63
An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for the quantification of aldosterone in human serum and plasma	56
Evaluation of the analytical and clinical performance of a new high-sensitivity cardiac troponin I assay: hs-cTnI (CLIA) assay	51
Measurement uncertainty estimation of free drug concentrations in clinical laboratories using equilibrium dialysis	49
Presence of SARS-CoV-2 RNA in COVID-19 survivors with post-COVID symptoms: a systematic review of the literature	47
Moving average quality control of routine chemistry and hematology parameters – a toolbox for implementation	46
Diagnostic performance of a point of care high-sensitivity cardiac troponin I assay and single measurement evaluation to rule out and rule in acute coronary syndrome	44
Design of an algorithm for the detection of intravenous fluid contamination in clinical laboratory samples	44
Overcoming challenges regarding reference materials and regulations that influence global standardization of medical laboratory testing results	38
Development of a liquid chromatography mass spectrometry method for the determination of vitamin K1, menaquinone-4, menaquinone-7 and vitamin K1-2,3 epoxide in serum of individuals without vitamin K s	38
Frontmatter	37
SYMPOSIUM 7 - Medical test standardization in the era of Metrological Traceability: who is accountable?	37
Web-accessible critical limits and critical values for urgent clinician notification	36
Discriminating signal from noise: the biological variation of circulating calprotectin in serum and plasma	36
ROUND-TABLE 1 - Beyond the Numbers: Integrating Laboratory and Clinical Perspectives on Thyroid Health	36
Machine learning-based delta check method for detecting misidentification errors in tumor marker tests	36
Analytical interference of intravascular contrast agents with clinical laboratory tests: a joint guideline by the ESUR Contrast Media Safety Committee and the Preanalytical Phase Working Group of the	35
Multiplex proteomics using proximity extension assay for the identification of protein biomarkers predictive of acute graft-vs.-host disease in allogeneic hematopoietic cell transplantation	34
Serial measurement of circulating calprotectin as a prognostic biomarker in COVID-19 patients in intensive care setting	33
Behind the scenes of EQA – characteristics, capabilities, benefits and assets of external quality assessment (EQA): Part II – EQA cycles	32

Results of a SARS-CoV-2 virus genome detection external quality assessment round focusing on sensitivity of assays and pooling of samples	31
Diagnostic performance of machine learning models using cell population data for the detection of sepsis: a comparative study	31
Cell population data: much more to explore	31
Insight into the status of plasma renin and aldosterone measurement: findings from 526 clinical laboratories in China	30
A novel LC-MS/MS-based assay for the simultaneous quantification of aldosterone-related steroids in human urine	30
Acetylcholine receptor and muscle-specific tyrosine kinase antibodies detection: is it time for a change?	30
Coagulation parameters in the newborn and infant – the Copenhagen Baby Heart and COMPARE studies	29
EN ISO 15189 revision: EFLM Committee Accreditation and ISO/CEN standards (C: A/ISO) analysis and general remarks on the changes	29
Quantification of blood glial fibrillary acidic protein using a second-generation microfluidic assay. Validation and comparative analysis with two established assays	29
Preanalytical quality improvement – an interdisciplinary journey	28
Multicenter study to compare the diagnostic performance of CLIA vs. FEIA transglutaminase IgA assays for the diagnosis of celiac disease	28
Not all biases are created equal: how to deal with bias on laboratory measurements	27
Frontmatter	27
Evaluation of biochemical algorithms to screen dysbetalipoproteinemia in ε2ε2 and rare APOE variants carriers	27
Reference intervals and decision limits	26
Frontmatter	26
Epigenetic signatures of cfDNA enable a topological assignment of tissue damage	26
Precision Medicine	25
ISMD2024 Thirteenth International Symposium on Molecular Diagnostics	25
Kidney diseases and transplantation, urinanalysis	25
The 10+1 Santorini Conference	25
53rd National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC – Laboratory Medicine)	24
Biological matrices, reagents and turnaround-time: the full-circle of artificial intelligence in the pre-analytical Phase. Comment on Turcic A, et al., Machine learning to optimize cerebrospinal fluid	24
Serum sPD-L1 levels are elevated in patients with viral diseases, bacterial sepsis or in patients with impaired renal function compared to healthy blood donors	23
Laboratory response to paradigm change in hemophilia treatment	23
Clinical utility of personalized reference intervals for CEA in the early detection of oncologic disease	23
Comparison of near-infrared and UV–vis-based non-contact hematocrit prediction of dried blood spots from patients on immunosuppressants	23
Neonatal reference intervals for serum steroid hormone concentrations measured by LC-MS/MS	23
Clinical Studies - Outcomes	23
What matters most: an age-friendly approach to pathology and laboratory medicine	22
An improved implementation of metrological traceability concepts is needed to benefit from standardization of laboratory results	22
IgA rheumatoid factor in rheumatoid arthritis	22
Frontmatter	22
A single dose of 20-mg of ostarine is detectable in hair	21
Analytical performance specifications – moving from models to practical recommendations	21
Emerging technology: a definition for laboratory medicine	21
Pseudo-erythroblastosis on Sysmex XN hematology analyzers: a clue to Candida sepsis. Case report and literature review	21
International collaborative study to evaluate and calibrate two recombinant L chain Ferritin preparations for use as a WHO International Standard	21
Response to Tony Badrick regarding “Letter to the Editor regarding the article by Wayne J. Dimech et al. Time to address quality control processes applied to antibody testing for infectious diseases.	21
External quality assurance (EQA): navigating between quality and sustainability	21
The impact of COVID-19 on citations of laboratory medicine journals	21
One fits all: a highly sensitive combined ddPCR/pyrosequencing system for the quantification of microchimerism after hematopoietic and solid organ transplantation	21
Use of the term “Bence-Jones proteinuria” in the EFLM European Urinalysis Guideline 2023	21
Long-term effects of interventions applied to optimize the use of 25-OH vitamin D tests in primary health care	21
Regulating the future of laboratory medicine: European regulatory landscape of AI-driven medical device software in laboratory medicine	20
SYMPOSIUM 1 - New approaches for deriving and applying biological variation data for clinical use	20
Pseudohyperglycemia due to glucometer interference in galactosemia	20
Familial dysalbuminemic hyperthyroxinemia coexisting with a Grave’s disease: a Belgian case report	20
Colorimetric correcting for sample concentration in stool samples	20
Contents	20

HTA model for laboratory medicine technologies: overview of approaches adopted in some international agencies	20
Benchmarking medical laboratory performance: survey validation and results for Europe, Middle East, and Africa	20
Microbiology - Infectious diseases including COVID 19	20
Refining within-subject biological variation estimation using routine laboratory data: practical applications of the refineR algorithm	20
Analytical evaluation of the novel Mindray high sensitivity cardiac troponin I immunoassay on CL-1200i	19
The role of analytical performance specifications in international guidelines and standards dealing with metrological traceability in laboratory medicine	19
Drainage fluid LDH and neutrophil to lymphocyte ratio as biomarkers for early detecting anastomotic leakage in patients undergoing colorectal surgery	19
An isotope dilution-liquid chromatography-tandem mass spectrometry based candidate reference measurement procedure for the simultaneous quantification of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2	18
A step forward in pediatric hemophagocytic lymphohistiocytosis and autoimmune disease: pediatric reference interval for serum soluble IL-2 receptor and soluble CD163	18
Linearity assessment: deviation from linearity and residual of linear regression approaches	18
Quality in laboratory medicine and the Journal: walking together	18
Cell population data for early detection of sepsis in patients with suspected infection in the emergency department	18
Clinical evidence requirements according to the IVDR 2017/746: practical tools and references for underpinning clinical evidence of IVD-MDs	18
Stability of plasma renin concentration based on plasma freezing time, as an adjunct to the stability data reported in the paper by Hepburn and others	18
Comprehensive evaluation of antiphospholipid antibody testing methodologies in APS diagnosis: performance comparisons across assay systems and clinical subtypes	18
Greater expectations: meeting clinical needs through broad and rapid genomic testing	18
Concordance between the updated Elecsys cerebrospinal fluid immunoassays and amyloid positron emission tomography for Alzheimer’s disease assessment: findings from the Apollo study	18
Dynamics of the vitamin D C3-epimer levels in preterm infants	17
Inherited disorders, metabolic disorders and rare diseases	17
IgG and kappa free light chain CSF/serum indices: evaluating intrathecal immunoglobulin production in HIV infection in comparison with multiple sclerosis	17
Evaluation of effects from hemoglobin variants on HbA1c measurements by different methods	17
Artificial intelligence in clinical applications for lung cancer: diagnosis, treatment and prognosis	17
‘Penelope test’: a practical instrument for checking appropriateness of laboratory tests	17
Biological variation of serum cholinesterase activity in healthy subjects	17
Biomarkers to measure the need and the effectiveness of therapeutic supplementation: a critical issue	17
Diabetes, obesity, metabolic syndrome	17
Lot-to-lot reagent verification: challenges and possible solutions	16
Frontmatter	16
Serous body fluid evaluation using the new automated haematology analyser Mindray BC-6800Plus	16
Understanding the limitations of your assay using EQA data with serum creatinine as an example	16
Remote monitoring and preanalytical challenges	16
Evaluation of reference intervals for classical and alternative pathway functional complement assays	16
Clinical evaluation of the OC-Sensor Pledia calprotectin assay	16
The role of Killer immunoglobulin-like receptors (KIRs) in the genetic susceptibility to non-celiac wheat sensitivity (NCWS)	16
Lot variation and inter-device differences contribute to poor analytical performance of the DCA Vantage™ HbA1c POCT instrument in a true clinical setting	16
Metrological traceability and test standardization/harmonization	16
A new milestone on the road to global standardization of apolipoprotein measurements	16
The preanalytical process in the emergency department, a European survey	16
Comparison between polynomial regression and weighted least squares regression analysis for verification of analytical measurement range	16
Performance evaluation and user experience of BT-50 transportation unit with automated and scheduled quality control measurements	15
An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure for the quantification of carbamazepine-10,11-epoxide in human serum an	15
Artificial intelligence - Informatics	15
Reply to: “Accurate predictory role of monocyte distribution width on short-term outcome in sepsis patients”	15
Copeptin as a diagnostic and prognostic biomarker in pediatric diseases	15
Evaluation of the interchangeability between the new fully-automated affinity chrome-mediated immunoassay (ACMIA) and the Quantitative Microsphere System (QMS) with a CE-IVD-certified LC-MS/MS assay f	15
Association of prehospital lactate levels with base excess in various emergencies – a retrospective study	15
Estimation of the reference values and decision limits for growth hormone in newborns using dried blood spots	15
Comparison of three different protocols for obtaining hemolysis	15
Improving regional medical laboratory center report quality through a report recall management system	14
The first case of Teclistamab interference with serum electrophoresis and immunofixation	14
A randomized controlled study of biochemical tests in primary care: interventions can reduce the number of tests but usage does not become more appropriate	14
Annual meeting of the Royal Belgian Society of Laboratory Medicine: “Symphony of the Heart”	14
Is it feasible for European laboratories to use SI units in reporting results?	14
Limitations of glycated albumin standardization when applied to the assessment of diabetes patients	14
Assessing the clinical applicability of dimensionality reduction algorithms in flow cytometry for hematologic malignancies	14
Accurate stratification between VEXAS syndrome and differential diagnoses by deep learning analysis of peripheral blood smears	14
Frontmatter	14
A physio-chemical mathematical model of the effects of blood analysis delay on acid-base, metabolite and electrolyte status: evaluation in blood from critical care patients	14
Quality indicators: an evolving target for laboratory medicine	14
Frontmatter	14
Kidney diseases	13
The biological variation of insulin resistance markers: data from the European Biological Variation Study (EuBIVAS)	13
Urine transfer devices may impact urinary particle results: a pre-analytical study	13
Diagnostic accuracy of extended HPV DNA genotyping and its application for risk-based cervical cancer screening strategy	13
Diagnosis of IRAK-4-deficiency by flow cytometric measurement of IκB-α degradation	13
S100B in cardiac surgery brain monitoring: friend or foe?	13
Variations in tumor growth, intra-individual biological variability, and the interpretation of changes	13
Tumor markers determination in malignant pleural effusion: pearls and pitfalls	13
New concept of interactive academic poster used in medical scientific congress presented in the EuroMedLab 2021 Munich Session	13
Haematology, including haemostasis	13
Assessment of the humoral response in Omicron breakthrough cases in healthcare workers who received the BNT162b2 booster	13
Validation and verification framework and data integration of biosensors and in vitro diagnostic devices: a position statement of the IFCC Committee on Mobile Health and Bioengineering in Labor	13
Flow-cytometric lymphocyte subsets enumeration: comparison of single/dual-platform method in clinical laboratory with dual-platform extended PanLeucogating method in reference laboratory	13
Clostebol detection after transdermal and transmucosal contact. A systematic review	13
Inconsistency in ferritin reference intervals across laboratories: a major concern for clinical decision making	13
Clinical implication by differential analytical performances of serum free light chain quantitation analysis using fully automated analyzers	13
Acknowledgment	13
Differences between high-sensitivity cardiac troponin T and I in stable populations: underlying causes and clinical implications	13
Unraveling the mystery of blood groups and COVID-19	13
In-house diagnostic devices under the EU IVDR and unwanted side-effects of intentional transparency	13

Setting analytical performance specifications for copeptin-based testing	13
Estimation of the allowable total error of the absolute CD34+ cell count by flow cytometry using data from UK NEQAS exercises 2004–2024	13
Arivale is dead ‒ Hooke is alive	13
Precise glucose measurement in sodium fluoride-citrate plasma affects estimates of prevalence in diabetes and prediabetes	13
Reference intervals of circulating secretoneurin concentrations determined in a large cohort of community dwellers: the HUNT study	12
Testosterone analysis in castrated prostate cancer patients: suitability of the castration cut-off and analytical accuracy of the present-day clinical immunoassays	12
Improved implementation of medical tests – barriers and opportunities	12
Evidence-based procedures to improve the reliability of circulating miRNA biomarker assays	12
Rare unstable and low oxygen affinity haemoglobin variant, Hb Hazebrouck, detected on Sysmex XN-9000	12
Transport stability profiling – a proposed generic protocol	12
Six years of progress – highlights from the IFCC Emerging Technologies Division	12
Nutrition Trace Elements and Vitamins	12
Performance evaluation of the introduction of full sample traceability system within the specimen collection process	12
The routine coagulation assays plasma stability – in the wake of the new European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) biological variability database	12
Diagnostic accuracy of adenosine deaminase for tuberculous pleural effusion: age does matter	12
Ct values of different SARS CoV2 variants: a single center observational study from Innsbruck, Austria	12
Kinetics and ability of binding antibody and surrogate virus neutralization tests to predict neutralizing antibodies against the SARS-CoV-2 Omicron variant following BNT162b2 booster administration	12
Striving for a pragmatic contribution of biomarkers results to lifelong health care	12
Artificial intelligence, clinical decision support and machine learning	12
Spike vs. nucleocapsid serum antigens for COVID-19 diagnosis and severity assessment	12
Laboratory Management, Accreditation, Quality Assurance, performance specification	11
A model for managing quality control for a network of clinical chemistry instruments measuring the same analyte	11
Evidence for stability of cardiac troponin T concentrations measured with a high sensitivity TnT test in serum and lithium heparin plasma after six-year storage at −80 °C and multiple freeze-thaw cycl	11
Chemical strategies for sustainable medical laboratories	11
An approach for determining allowable between reagent lot variation	11
Sepsis	11
Frontmatter	11
C-terminal alpha-1-antitrypsin peptides as novel predictor of hospital mortality in critically ill COVID-19 patients	11
M-protein diagnostics in multiple myeloma patients using ultra-sensitive targeted mass spectrometry and an off-the-shelf calibrator	11
Review and evolution of guidelines for diagnosis of COVID-19 vaccine induced thrombotic thrombocytopenia (VITT)	11
Novel protocol for metabolomics data normalization and biomarker discovery in human tears	11
The effects of drone transportation on routine laboratory, immunohematology, flow cytometry and molecular analyses	11
Where is laboratory medicine headed in the next decade? Partnership model for efficient integration and adoption of artificial intelligence into medical laboratories	11
Histamine metabolite to basal serum tryptase ratios in systemic mastocytosis and hereditary alpha tryptasemia using a validated LC-MS/MS approach	11
The total testing process harmonization: the case study of SARS-CoV-2 serological tests	11
Neurological diseases	11
Frontmatter	11
Interferences in immunoassays: review and practical algorithm	11
Comparison between free β subunit of human chorionic gonadotropin (hCG) and total hCG assays in adults with testicular cancer	11
Preanalytical phase	11
A survey on Artificial Intelligence and Big Data utilisation in Italian clinical laboratories	11
SARS CoV-2 spike protein-guided exosome isolation facilitates detection of potential miRNA biomarkers in COVID-19 infections	11
Symposium 13 - Prenatal testing	11
16ª Reunião Científica da Sociedade Portuguesa de Medicina Laboratorial - SPML	11
Serum biomarkers of remodeling in severe asthma with fixed airway obstruction and the potential role of KL-6	10
Analytical and clinical evaluations of Snibe Maglumi® S100B assay	10
Association of circulating free and total oxysterols in breast cancer patients	10
Spurious parathyroid hormone (PTH) elevation caused by macro-PTH	10
First-trimester screening for Down syndrome using quadruple maternal biochemical markers	10
Correction of negative-interference from calcium dobesilate in the Roche sarcosine oxidase creatinine assay using CuO	10
Patient risk management in laboratory medicine: an international survey to assess the severity of harm associated with erroneous reported results	10
Biological variation of serum iron from the European biological variation study (EuBIVAS)	10
An overview of the most important preanalytical factors influencing the clinical performance of SARS-CoV-2 antigen rapid diagnostic tests (Ag-RDTs)	10
External quality assessment of serum indices: Spanish SEQC-ML program	10
Positivization time of a COVID-19 rapid antigen self-test predicts SARS-CoV-2 viral load: a proof of concept	10
Is uracil enough for effective pre-emptive DPD testing?	10
Measuring accuracy of the neutralizing activity of COVID-19 convalescent plasma	10
A novel immunoprecipitation-based targeted liquid chromatography-tandem mass spectrometry analysis for accurate determination for copeptin in human serum	10
Traceable machine learning real-time quality control based on patient data	10
Searching for the urine osmolality surrogate: an automated machine learning approach	10
Tutorial: statistical methods for the meta-analysis of diagnostic test accuracy studies	10
Use of high-sensitivity cardiac troponins in the emergency department for the early rule-in and rule-out of acute myocardial infarction without persistent ST-segment elevation (NSTEMI) in Italy	10
Can we identify patients carrying targeted deleterious DPYD variants with plasma uracil and dihydrouracil? A GPCO-RNPGx retrospective analysis	10
Using artificial intelligence in a primary care setting to identify patients at risk for cancer: a risk prediction model based on routine laboratory tests	10
Toxicology and TDM	10
Immunology	10
Diagnostic performance of Mindray CL1200i high sensitivity cardiac troponin I assay compared to Abbott Alinity cardiac troponin I assay for the diagnosis of type 1 and 2 acute myocardial infarction in	10
A screening method to spot biomarkers that may warn of serious events in a chronic disease – illustrated by cardiological CLARICOR trial data	10
An appeal for biological variation estimates in deep immunophenotyping	9
Committees	9
Added value of drug-laboratory test interaction alerts in test result authorisation	9
Allowable total error in CD34 cell analysis by flow cytometry based on state of the art using Spanish EQAS data	9
Temporal biomarker concentration patterns during the early course of acute coronary syndrome	9
Frontmatter	9
Lot-to-lot bias for high-sensitivity cardiac troponin I concentrations ≥1000 ng/L	9
Clearance of macro-TSH from the circulation is slower than TSH	9
Macroprolactinaemia – some progress but still an ongoing problem	9
Method comparison of three serum free light chain assays on the Roche Cobas 6000 c501 chemistry analyzer	9
Pre-analytical recommendations and reference values for circulating calprotectin are sample type and assay dependent	9
Is this a true lambda free light chain?	9
Two cases of MTHFR C677T polymorphism typing failure by Taqman system due to MTHFR 679 GA heterozygous mutation	9
Biological variation, reference change values and index of individuality of GDF-15	9
Impact of ultra-low temperature long-term storage on the preanalytical variability of twenty-one common biochemical analytes	9
Reference intervals for high sensitivity cardiac troponin I and N-terminal pro-B-type natriuretic peptide in children and adolescents on the Siemens Atellica	9
Analytical performance specifications based on biological variation data – considerations, strengths and limitations	9
Commercial immunoassays for detection of anti-SARS-CoV-2 spike and RBD antibodies: urgent call for validation against new and highly mutated variants	9
Validation of (self-collected) capillary blood using a topper collection system as alternative for venous sampling for 15 common clinical chemistry analytes	9
Impact of different preservation methods on urinary red blood cell counts	9
IFCC Symposium - Advancing Excellence in Laboratory Medicine Worldwide: An Update from IFCC Taskforces	9
Endocrinology, not including diabetes	9
Reference values for plasma neurofilament light chain in healthy Chinese children	9
Point of Care testing, critical care, emergency medicine	9
Detection of urinary foam cells diagnosing the XGP with thrombopenia preoperatively: a case report	9
The journey to pre-analytical quality	9
Standardization challenges in antipsychotic drug monitoring: insights from a national survey in Chinese TDM practices	9