OOIR: Observatory of International Research

Papers

(The H4-Index of International Journal of Biological Sciences is 54. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer	215
MKL-1 suppresses ferroptosis by activating system Xc- and increasing glutathione synthesis	192
COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2	190
Reconstruction of the Hepatic Microenvironment and Pathological Changes Underlying Type II Diabetes through Single-Cell RNA Sequencing	189
A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer	158
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells	156
Digging out MDIG from the mess of H3K9me3, OTX2 and MYC signaling in human cancers	138
Comprehensive Histopathology Imaging in Pancreatic Biopsies: High Definition Infrared Imaging with Machine Learning Approach	128
The dysadherin/FAK axis promotes individual cell migration in colon cancer	127
Dysregulated Ribosome Biogenesis Is a Targetable Vulnerability in Triple-Negative Breast Cancer: MRPS27 as a Key Mediator of the Stemness-inhibitory Effect of Lovastatin	116
PPDPF Promotes the Progression and acts as an Antiapoptotic Protein in Non-Small Cell Lung Cancer	114
Antioxidant genes in cancer and metabolic diseases: Focusing on Nrf2, Sestrin, and heme oxygenase 1	112
Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma	110
RNA-binding motif protein 10 represses tumor progression through the Wnt/β- catenin pathway in lung adenocarcinoma	108
Pathogenesis and treatment strategies of sepsis-induced myocardial injury: modern and traditional medical perspectives	103
Loss of DDRGK1 impairs IRE1α UFMylation in spondyloepiphyseal dysplasia	103
SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer	101
Nlp-dependent ER-to-Golgi transport	100
Cancer-associated fibroblasts promote migration and invasion of non-small cell lung cancer cells via METTL3-mediated RAC3 m⁶A modification	100
Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers	99
P2RY13 Exacerbates Intestinal Inflammation by Damaging the Intestinal Mucosal Barrier via Activating IL-6/STAT3 Pathway	90
As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma	89
Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice	88
TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver disease via nitric oxide production	85
Extracellular vesicles, the emerging mirrors of brain physiopathology	85

The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis In Vitro and In Vivo	81
Regulation of lung epithelial cell senescence in smoking-induced COPD/emphysema by microR-125a-5p via Sp1 mediation of SIRT1/HIF-1a	78
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases	78
Inhibition of the HMGB1/RAGE axis protects against cisplatin-induced ototoxicity via suppression of inflammation and oxidative stress	76
The role of RGC degeneration in the pathogenesis of glaucoma	74
Glycine Decarboxylase Regulates Renal Carcinoma Progression via Interferon Stimulated Gene Factor 3-Mediated Pathway	72
TBX21 inhibits colorectal cancer metastasis through ARHGAP29/GSK3β inhibitory signaling- and MYCT1/ZO-1 signaling-dependent manner	72
CD151 promotes Colorectal Cancer progression by a crosstalk involving CEACAM6, LGR5 and Wnt signaling via TGFβ1: Erratum	70
Immunosenescence, Physical Exercise, and their Implications in Tumor Immunity and Immunotherapy	69
tRF-27 competitively Binds to G3BPs and Activates MTORC1 to Enhance HER2 Positive Breast Cancer Trastuzumab Tolerance	69
Cardiovascular-related proteomic changes in ECFCs exposed to the serum of COVID-19 patients	68
Polysaccharide isolated from Grifola frondosa eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T cells responses	66
HNRNPK/CLCN3 axis facilitates the progression of LUAD through CAF-tumor interaction	65
TRIM37 Augments AP-2γ Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression	65
ITGB4 deficiency induces mucus hypersecretion by upregulating MUC5AC in RSV-infected airway epithelial cells	63
Ferroptosis-associated molecular classification characterized by distinct tumor microenvironment profiles in colorectal cancer	62
Activation of central Angiotensin-(1-7)/Mas receptor alleviates synaptic damage in diabetes-associated cognitive impairment via modulating AKT/FOXO1/PACAP axis	62
Towards a “Testis in a Dish”: Generation of Mouse Testicular Organoids that Recapitulate Testis Structure and Expression Profiles	61
PROX1-mediated epigenetic silencing of SIRT3 contributes to proliferation and glucose metabolism in colorectal cancer	60
Targeting Necroptosis: A Novel Therapeutic Option for Retinal Degenerative Diseases	57
Traditional Chinese Medicine JingYinGuBiao Formula Therapy Improves the Negative Conversion Rate of SARS-CoV2 in Patients with Mild COVID-19	57
Identification of Gαi3 as a promising target for osteosarcoma treatment	57
Mannan-Binding Lectin Deficiency Limits Inflammation-induced Myeloid-Derived Suppressor Cells Expansion via Modulating Tumor Necrosis Factor Alpha-triggered Apoptosis	56
Treatment for type 2 diabetes and diabetic nephropathy by targeting Smad3 signaling	56
PSMC6 regulation of ovarian cancer cisplatin resistance unravels a new mode for proteasome targeting	55
Dual-specificity tyrosine-regulated kinase 4 modulates the STAT3-FOS signaling axis to inhibit hepatitis B virus replication via autophagy	55
Theophylline derivatives promote primordial follicle activation via cAMP-PI3K/Akt pathway and ameliorate fertility deficits in naturally aged mice	55
TSG-6 promotes Cancer Cell aggressiveness in a CD44-Dependent Manner and Reprograms Normal Fibroblasts to create a Pro-metastatic Microenvironment in Colorectal Cancer	54
The Novel Role of hnRNP UL1 in Human Cell Nucleoli	54