OOIR: Observatory of International Research

Papers

(The H4-Index of International Journal of Biological Sciences is 57. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer	240
MKL-1 suppresses ferroptosis by activating system Xc- and increasing glutathione synthesis	212
The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis In Vitro and In Vivo	205
Reconstruction of the Hepatic Microenvironment and Pathological Changes Underlying Type II Diabetes through Single-Cell RNA Sequencing	194
A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer	184
Digging out MDIG from the mess of H3K9me3, OTX2 and MYC signaling in human cancers	175
Loss of DDRGK1 impairs IRE1α UFMylation in spondyloepiphyseal dysplasia	147
Exosomes: a promising microenvironment modulator for spinal cord injury treatment	145
Mechanistic role of metal-responsive transcription factor-1 (MTF-1) in cadmium-induced prostate carcinogenesis	137
Comprehensive Histopathology Imaging in Pancreatic Biopsies: High Definition Infrared Imaging with Machine Learning Approach	136
The dysadherin/FAK axis promotes individual cell migration in colon cancer	134
PPDPF Promotes the Progression and acts as an Antiapoptotic Protein in Non-Small Cell Lung Cancer	133
COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2	125
Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers	116
Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma	114
Extracellular vesicles, the emerging mirrors of brain physiopathology	113
As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma	111
Cancer-associated fibroblasts promote migration and invasion of non-small cell lung cancer cells via METTL3-mediated RAC3 m⁶A modification	109
Pathogenesis and treatment strategies of sepsis-induced myocardial injury: modern and traditional medical perspectives	109
Nlp-dependent ER-to-Golgi transport	104
SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway	104
TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver disease via nitric oxide production	104
Dysregulated Ribosome Biogenesis Is a Targetable Vulnerability in Triple-Negative Breast Cancer: MRPS27 as a Key Mediator of the Stemness-inhibitory Effect of Lovastatin	102
RNA-binding motif protein 10 represses tumor progression through the Wnt/β- catenin pathway in lung adenocarcinoma	98
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells	95

SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer	94
P2RY13 Exacerbates Intestinal Inflammation by Damaging the Intestinal Mucosal Barrier via Activating IL-6/STAT3 Pathway	90
Antioxidant genes in cancer and metabolic diseases: Focusing on Nrf2, Sestrin, and heme oxygenase 1	85
Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma	85
Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice	81
Inhibition of the HMGB1/RAGE axis protects against cisplatin-induced ototoxicity via suppression of inflammation and oxidative stress	79
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases	78
Regulation of lung epithelial cell senescence in smoking-induced COPD/emphysema by microR-125a-5p via Sp1 mediation of SIRT1/HIF-1a	78
TBX21 inhibits colorectal cancer metastasis through ARHGAP29/GSK3β inhibitory signaling- and MYCT1/ZO-1 signaling-dependent manner	75
Glycine Decarboxylase Regulates Renal Carcinoma Progression via Interferon Stimulated Gene Factor 3-Mediated Pathway	73
CD151 promotes Colorectal Cancer progression by a crosstalk involving CEACAM6, LGR5 and Wnt signaling via TGFβ1: Erratum	73
TRIM37 Augments AP-2γ Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression	71
Cardiovascular-related proteomic changes in ECFCs exposed to the serum of COVID-19 patients	71
Activation of central Angiotensin-(1-7)/Mas receptor alleviates synaptic damage in diabetes-associated cognitive impairment via modulating AKT/FOXO1/PACAP axis	70
PROX1-mediated epigenetic silencing of SIRT3 contributes to proliferation and glucose metabolism in colorectal cancer	70
The role of RGC degeneration in the pathogenesis of glaucoma	68
HNRNPK/CLCN3 axis facilitates the progression of LUAD through CAF-tumor interaction	67
RNA methylation-mediated LINC01559 suppresses colorectal cancer progression by regulating the miR-106b-5p/PTEN axis	65
Targeting Necroptosis: A Novel Therapeutic Option for Retinal Degenerative Diseases	65
Mannan-Binding Lectin Deficiency Limits Inflammation-induced Myeloid-Derived Suppressor Cells Expansion via Modulating Tumor Necrosis Factor Alpha-triggered Apoptosis	64
The Crosstalk between Autophagy and Nrf2 Signaling in Cancer: from Biology to Clinical Applications	64
PSMC6 regulation of ovarian cancer cisplatin resistance unravels a new mode for proteasome targeting	63
Ugonin P mitigates osteolytic bone metastasis by suppressing MDK via upregulating miR-223-3p expression	62
The Novel Role of hnRNP UL1 in Human Cell Nucleoli	62
C3G down-regulation enhances pro-migratory and stemness properties of oval cells by promoting an epithelial-mesenchymal-like process	61
N-Acetylcysteine Alleviates Depressive-Like Behaviors in Adolescent EAAC1^-/- Mice and Early Life Stress Model Rats	60
Identification of Gαi3 as a promising target for osteosarcoma treatment	60
Dual-specificity tyrosine-regulated kinase 4 modulates the STAT3-FOS signaling axis to inhibit hepatitis B virus replication via autophagy	59
Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1	59
Treatment for type 2 diabetes and diabetic nephropathy by targeting Smad3 signaling	57
Ferroptosis-associated molecular classification characterized by distinct tumor microenvironment profiles in colorectal cancer	57
IL-6/STAT3 Axis Activates Glut5 to Regulate Fructose Metabolism and Tumorigenesis	57