OOIR: Observatory of International Research

Papers

(The H4-Index of International Journal of Biological Sciences is 56. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer	287
Piezo1-driven mechanotransduction regulates mitochondrial biogenesis by AMPK/SIRT1-mediated PGC-1α deacetylation to ameliorate bone loss in disuse osteoporosis	222
Crosstalk between arachidonic acid metabolism and glycolysis drives integrated metabolic-inflammatory reprogramming in macrophages	201
Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers	198
Antioxidant genes in cancer and metabolic diseases: Focusing on Nrf2, Sestrin, and heme oxygenase 1	194
SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer	158
Stem cells enhance their chondrogenic differentiation in hydrogels by mechanical tumbling	150
MKL-1 suppresses ferroptosis by activating system Xc- and increasing glutathione synthesis	144
Targeting Lysosomes for Enhanced Anti-Cancer Therapeutics and Immune Response	136
Exosomes: a promising microenvironment modulator for spinal cord injury treatment	130
SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway	128
Excessive Kynurenine Metabolism Impairs Lysosomal acidification and Triggers mtDNA Release via the AHR/CISH/ATP6V1A Axis in Decidual Macrophages Associated with Unexplained Recurrent Pregnancy Loss	126
Outer Membrane Vesicles Derived from Oral Bacteria Act as a Dagger in Host Immunity: Insight Tips from Local Diseases to Systemic Effects	108
TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver disease via nitric oxide production	106
Extracellular vesicles, the emerging mirrors of brain physiopathology	100
Loss of DDRGK1 impairs IRE1α UFMylation in spondyloepiphyseal dysplasia	96
ETV4 interacts with LOXL2 to induce epigenetic activation of NID1 during colorectal cancer progression	96
Gut Microbiota-Driven Pathways Linking Chronic Stress to Tumor Progression	91
Cancer-associated fibroblasts promote migration and invasion of non-small cell lung cancer cells via METTL3-mediated RAC3 m⁶A modification	91
Inhibition of the HMGB1/RAGE axis protects against cisplatin-induced ototoxicity via suppression of inflammation and oxidative stress	89
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases	88
Macrophages in Focus: Key Drivers and Therapeutic Opportunities in Diabetic Kidney Disease	88
Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys	87
GIPC1 Restrains the Progression and Chemoresistance of Colorectal Cancer by Regulating TTC7B/mTOR/NF-κB Axis	86
Nlp-dependent ER-to-Golgi transport	85

The dysadherin/FAK axis promotes individual cell migration in colon cancer	76
Mechanistic role of metal-responsive transcription factor-1 (MTF-1) in cadmium-induced prostate carcinogenesis	75
Targeting the HSP60/p53 Axis with Extracellular Vesicle-Delivered siRNA Reprograms Glycolysis in Prostate Cancer	74
Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma	73
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells	70
The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis In Vitro and In Vivo	70
Dysregulated Ribosome Biogenesis Is a Targetable Vulnerability in Triple-Negative Breast Cancer: MRPS27 as a Key Mediator of the Stemness-inhibitory Effect of Lovastatin	70
Therapeutic Activation of PPARα Inhibits Transformed Follicular Lymphoma Tumorigenesis via the FOXM1 Signaling Pathway	68
Pathogenesis and treatment strategies of sepsis-induced myocardial injury: modern and traditional medical perspectives	68
Comprehensive Histopathology Imaging in Pancreatic Biopsies: High Definition Infrared Imaging with Machine Learning Approach	67
A crosstalk between tumor cells and adipocytes facilitates tumor cell migration and invasion	66
Reconstruction of the Hepatic Microenvironment and Pathological Changes Underlying Type II Diabetes through Single-Cell RNA Sequencing	65
Digging out MDIG from the mess of H3K9me3, OTX2 and MYC signaling in human cancers	65
CD151 promotes Colorectal Cancer progression by a crosstalk involving CEACAM6, LGR5 and Wnt signaling via TGFβ1: Erratum	64
p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer	64
PSMC6 regulation of ovarian cancer cisplatin resistance unravels a new mode for proteasome targeting	63
TBX21 inhibits colorectal cancer metastasis through ARHGAP29/GSK3β inhibitory signaling- and MYCT1/ZO-1 signaling-dependent manner	61
Altered Heme and Redox Homeostasis Underpin Late-onset Alzheimer's Disease	61
IL-38 Aggravates Atopic Dermatitis via Facilitating Migration of Langerhans cells	60
Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1	60
N-Acetylcysteine Alleviates Depressive-Like Behaviors in Adolescent EAAC1^-/- Mice and Early Life Stress Model Rats	60
Orphan Nuclear Receptor NR4A1 Promotes Proliferation and Osteogenic Differentiation of Valvular Interstitial Cells through Activation of CCND2	59
m⁶A RNA methylation drives kidney fibrosis by upregulating β-catenin signaling	59
1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice	59
Paris saponin VII reverses resistance to PARP inhibitors by regulating ovarian cancer tumor angiogenesis and glycolysis through the RORα/ECM1/VEGFR2 signaling axis	58
Comprehensive Analyses Reveal Effects on Tumor Immune Infiltration and Immunotherapy Response of APOBEC Mutagenesis and Its Molecular Mechanisms in Esophageal Squamous Cell Carcinoma	57
Treatment for type 2 diabetes and diabetic nephropathy by targeting Smad3 signaling	56
Ugonin P mitigates osteolytic bone metastasis by suppressing MDK via upregulating miR-223-3p expression	56
Theophylline derivatives promote primordial follicle activation via cAMP-PI3K/Akt pathway and ameliorate fertility deficits in naturally aged mice	56
NUF2 Drives Cholangiocarcinoma Progression and Migration via Inhibiting Autophagic Degradation of TFR1	56
PTPN22 Dephosphorylates CBL to Inhibit PD-L1 Ubiquitination and Drive Immunosuppression in Renal Cell Carcinoma	56