OOIR: Observatory of International Research

Papers

(The TQCC of International Journal of Biological Sciences is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer	308
Stem cells enhance their chondrogenic differentiation in hydrogels by mechanical tumbling	224
The dysadherin/FAK axis promotes individual cell migration in colon cancer	213
MKL-1 suppresses ferroptosis by activating system Xc- and increasing glutathione synthesis	208
Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys	204
Crosstalk between arachidonic acid metabolism and glycolysis drives integrated metabolic-inflammatory reprogramming in macrophages	162
Mechanistic role of metal-responsive transcription factor-1 (MTF-1) in cadmium-induced prostate carcinogenesis	159
Targeting the HSP60/p53 Axis with Extracellular Vesicle-Delivered siRNA Reprograms Glycolysis in Prostate Cancer	157
Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers	149
Nlp-dependent ER-to-Golgi transport	134
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells	133
GIPC1 Restrains the Progression and Chemoresistance of Colorectal Cancer by Regulating TTC7B/mTOR/NF-κB Axis	133
p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer	113
Reconstruction of the Hepatic Microenvironment and Pathological Changes Underlying Type II Diabetes through Single-Cell RNA Sequencing	112
Excessive Kynurenine Metabolism Impairs Lysosomal acidification and Triggers mtDNA Release via the AHR/CISH/ATP6V1A Axis in Decidual Macrophages Associated with Unexplained Recurrent Pregnancy Loss	108
Dysregulated Ribosome Biogenesis Is a Targetable Vulnerability in Triple-Negative Breast Cancer: MRPS27 as a Key Mediator of the Stemness-inhibitory Effect of Lovastatin	108
Cancer-associated fibroblasts promote migration and invasion of non-small cell lung cancer cells via METTL3-mediated RAC3 m⁶A modification	105
SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway	98
Gut Microbiota-Driven Pathways Linking Chronic Stress to Tumor Progression	94
Loss of DDRGK1 impairs IRE1α UFMylation in spondyloepiphyseal dysplasia	94
ETV4 interacts with LOXL2 to induce epigenetic activation of NID1 during colorectal cancer progression	93
Antioxidant genes in cancer and metabolic diseases: Focusing on Nrf2, Sestrin, and heme oxygenase 1	93
Macrophages in Focus: Key Drivers and Therapeutic Opportunities in Diabetic Kidney Disease	91
Comprehensive Histopathology Imaging in Pancreatic Biopsies: High Definition Infrared Imaging with Machine Learning Approach	89
Digging out MDIG from the mess of H3K9me3, OTX2 and MYC signaling in human cancers	88

A crosstalk between tumor cells and adipocytes facilitates tumor cell migration and invasion	80
Extracellular vesicles, the emerging mirrors of brain physiopathology	78
Pathogenesis and treatment strategies of sepsis-induced myocardial injury: modern and traditional medical perspectives	76
TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver disease via nitric oxide production	75
Inhibition of the HMGB1/RAGE axis protects against cisplatin-induced ototoxicity via suppression of inflammation and oxidative stress	73
SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer	72
Targeting Lysosomes for Enhanced Anti-Cancer Therapeutics and Immune Response	72
Therapeutic Activation of PPARα Inhibits Transformed Follicular Lymphoma Tumorigenesis via the FOXM1 Signaling Pathway	71
Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma	71
The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis In Vitro and In Vivo	70
Outer Membrane Vesicles Derived from Oral Bacteria Act as a Dagger in Host Immunity: Insight Tips from Local Diseases to Systemic Effects	70
Exosomes: a promising microenvironment modulator for spinal cord injury treatment	68
CD151 promotes Colorectal Cancer progression by a crosstalk involving CEACAM6, LGR5 and Wnt signaling via TGFβ1: Erratum	67
Piezo1-driven mechanotransduction regulates mitochondrial biogenesis by AMPK/SIRT1-mediated PGC-1α deacetylation to ameliorate bone loss in disuse osteoporosis	67
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases	67
Altered Heme and Redox Homeostasis Underpin Late-onset Alzheimer's Disease	65
TBX21 inhibits colorectal cancer metastasis through ARHGAP29/GSK3β inhibitory signaling- and MYCT1/ZO-1 signaling-dependent manner	63
IL-38 Aggravates Atopic Dermatitis via Facilitating Migration of Langerhans cells	63
Comprehensive Analyses Reveal Effects on Tumor Immune Infiltration and Immunotherapy Response of APOBEC Mutagenesis and Its Molecular Mechanisms in Esophageal Squamous Cell Carcinoma	62
Ugonin P mitigates osteolytic bone metastasis by suppressing MDK via upregulating miR-223-3p expression	62
Orphan Nuclear Receptor NR4A1 Promotes Proliferation and Osteogenic Differentiation of Valvular Interstitial Cells through Activation of CCND2	62
NUF2 Drives Cholangiocarcinoma Progression and Migration via Inhibiting Autophagic Degradation of TFR1	62
PROX1-mediated epigenetic silencing of SIRT3 contributes to proliferation and glucose metabolism in colorectal cancer	60
Dual-specificity tyrosine-regulated kinase 4 modulates the STAT3-FOS signaling axis to inhibit hepatitis B virus replication via autophagy	60
PSMC6 regulation of ovarian cancer cisplatin resistance unravels a new mode for proteasome targeting	60
Polysaccharide isolated from Grifola frondosa eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T cells responses	60
Immunosenescence, Physical Exercise, and their Implications in Tumor Immunity and Immunotherapy	59
NLRX1 Drives Prostate Cancer Progression Through Activation of AKT and ERK Signaling Pathways	59
N-Acetylcysteine Alleviates Depressive-Like Behaviors in Adolescent EAAC1^-/- Mice and Early Life Stress Model Rats	58
Novel glycoprotein SBSPON suppressed bladder cancer through the AKT signal pathway by inhibiting HSPA5 membrane translocation	58
Oxidative stress promotes liver fibrosis by modulating the microRNA-144 and SIN3A-p38 pathways in hepatic stellate cells	58
Paris saponin VII reverses resistance to PARP inhibitors by regulating ovarian cancer tumor angiogenesis and glycolysis through the RORα/ECM1/VEGFR2 signaling axis	58
The Crosstalk between Autophagy and Nrf2 Signaling in Cancer: from Biology to Clinical Applications	57
Extracellular Vesicles in Mental Disorders: A State-of-art Review	57
Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1	56
Towards a “Testis in a Dish”: Generation of Mouse Testicular Organoids that Recapitulate Testis Structure and Expression Profiles	56
Fangchinoline Activates cGAS-STING to Promote Antitumor Immunity without Pathological Inflammation	54
Impaired redox adaptation through SLC38A5-dependent glutamine metabolism contributes to melatonin-mediated anoikis sensitivity and metastasis suppression in bone cancer	53
Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress	52
Activation of central Angiotensin-(1-7)/Mas receptor alleviates synaptic damage in diabetes-associated cognitive impairment via modulating AKT/FOXO1/PACAP axis	52
The role of RGC degeneration in the pathogenesis of glaucoma	51
Glycine Decarboxylase Regulates Renal Carcinoma Progression via Interferon Stimulated Gene Factor 3-Mediated Pathway	51
Coenzyme Q₀ inhibited the NLRP3 inflammasome, metastasis/EMT, and Warburg effect by suppressing hypoxia-induced HIF-1α expression in HNSCC cells	51
Cardiovascular-related proteomic changes in ECFCs exposed to the serum of COVID-19 patients	50
TM4SF5-mediated KEAP1 Regulation in Hepatocytes Irrelevant to NRF2 Expression and Activity Promotes Oxidative Stress and Inflammation to Develop Metabolic Dysfunction-Associated Steatotic Liver Diseas	50
Treatment for type 2 diabetes and diabetic nephropathy by targeting Smad3 signaling	49
PTPN22 Dephosphorylates CBL to Inhibit PD-L1 Ubiquitination and Drive Immunosuppression in Renal Cell Carcinoma	49
Methyltransferase Set7/9 as a Multifaceted Regulator of ROS Response	48
m⁶A RNA methylation drives kidney fibrosis by upregulating β-catenin signaling	48
tRF-27 competitively Binds to G3BPs and Activates MTORC1 to Enhance HER2 Positive Breast Cancer Trastuzumab Tolerance	48

Irisin attenuates vascular remodeling in hypertensive mice induced by Ang II by suppressing Ca²⁺-dependent endoplasmic reticulum stress in VSMCs	48
The Role of Thrombospondins in Osteoarthritis: from Molecular Mechanisms to Therapeutic Potential	47
G against Glioma: G protein inhibitory α subunit 2 (Gαi2) as a novel glioma target	47
Targeting Necroptosis: A Novel Therapeutic Option for Retinal Degenerative Diseases	47
Targeting ALG3/FOXD1/BNIP3 Axis Prevents Mitophagy and Gemcitabine Resistance of Nasopharyngeal Carcinoma	47
Theophylline derivatives promote primordial follicle activation via cAMP-PI3K/Akt pathway and ameliorate fertility deficits in naturally aged mice	47
CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways: Erratum	47
1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice	47
DHCR24 Deficiency Drives Age-Related Meibomian Gland Dysfunction by Regulating Lipid Metabolic Imbalance and Cytosolic mtDNA-Induced cGAS-STING Activation	46
NUDT7 Modulates the UBA52-SREBF1 Signaling Axis to Promote PRRSV Replication via Lipid Synthesis	46
Abnormal mechanical load aggravates subchondral bone remodeling and uneven tibial plateau settlement in knee osteoarthritis via activation of osteoblast Piezo1-Ca²⁺-JAK2/STAT3 signaling	46
Melatonin modulates the hypothalamic-pituitary neuroendocrine axis to regulate physiological color change in teleost fish	46
RUNX1-PDIA5 Axis Promotes Malignant Progression of Glioblastoma by Regulating CCAR1 Protein Expression	45
A positive feedback loop of CENPU/E2F6/E2F1 facilitates proliferation and metastasis via ubiquitination of E2F6 in hepatocellular carcinoma: Erratum	45
IKBKE regulates renal cell carcinoma progression and sunitinib resistance through the RRM2-AKT pathway	45
BRD7 enhances the radiosensitivity of nasopharyngeal carcinoma cells by negatively regulating USP5/METTL3 axis-mediated homologous recombination repair	45
Androgen receptor suppresses lung cancer invasion and increases cisplatin response via decreasing TPD52 expression	45
miR-199a-3p/5p regulate tumorgenesis via targeting Rheb in non-small cell lung cancer: Erratum	45
Cisplatin-induced Pyroptosis Enhances the Efficacy of PD-L1 Inhibitor in Small-Cell Lung Cancer via GSDME/IL12/CD4Tem Axis	44
A Small Molecule Selectively Targets N-Myc to Suppress Neuroblastoma Cancer Progression	44
Therapeutic implications for localized prostate cancer by multiomics analyses of the ageing microenvironment landscape	44
UPP1 enhances bladder cancer progression and gemcitabine resistance through AKT	44
Recent Trends in anti-tumor mechanisms and molecular targets of celastrol	43
Interruption of p38^MAPK-MSK1-CREB-MITF-M pathway to prevent hyperpigmentation in the skin	43
Neferine Ameliorates Severe Acute Pancreatitis-Associated Intestinal Injury by Promoting NRF2-mediated Ferroptosis	43
Citrus Pectin Supplementation Alleviated Hepatic Lipid Accumulation through Gut Microbiota Indole Lactic Acid Promoting Hepatic Bile Acid Synthesis and Excretion	43
Inhibition of GRK2-PDE4D Axis Suppresses Fibroblast-Like Synoviocytes Hyperplasia and Alleviates Experimental Arthritis	43
Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea	41
Microbiota-Gut-Kidney Axis and Targeted Therapeutic Strategies in Kidney Diseases	41
The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer	41
Ferritinophagy activation states determine the susceptibility to ferroptosis of macrophages in bone marrow and spleen	41
METTL18 functions as a Phenotypic Regulator in Src-Dependent Oncogenic Responses of HER2-Negative Breast Cancer	40
CBX8 suppresses autophagy-dependent senescence in colorectal cancer by modulating the mTOR signaling pathway	40
The E3 ubiquitin ligase MAEA promotes macrophage phagocytosis and inhibits gastrointestinal cancer progression by mediating PARP1 ubiquitination and degradation	39
Metabolic Checkpoints in CD8 ⁺ T Cells within the Tumor Microenvironment: A Comprehensive Review and Emerging Insights	39
PARP inhibitor augments anti-tumor efficacy of DNMT inhibitor by inducing senescence in cholangiocarcinoma	39
CLDN6 induces chemoresistance through protective autophagy in breast cancer	38
Clusterin Inhibits Neuronal Ferroptosis via the PI3K-AKT-mTOR-SREBP1 Axis to Promote Functional Recovery after Spinal Cord Injury	38
Loss of BATF3 impairs adipose-liver homeostasis and accelerates the transition from steatosis to fibrosis in high-fat diet-fed mice	38
TEAD1 Prevents Necroptosis and Inflammation in Cisplatin-Induced Acute Kidney Injury Through Maintaining Mitochondrial Function	37
Emerging Role of Ferroptosis in Diabetic Kidney Disease: Molecular Mechanisms and Therapeutic Opportunities	37
The FTO-CMPK2 Pathway in Fibroblast-like Synoviocytes Modulates Rheumatoid Arthritis Synovial Inflammation and Cartilage Homeostasis via mtDNA Regulation	37
Reprogramming of Lipid Metabolism Mediates Crosstalk, Remodeling, and Intervention of Microenvironment Components in Breast Cancer	37
Customized liver organoids as an advanced in vitro modeling and drug discovery platform for non-alcoholic fatty liver diseases	37
HIF-2α/LPCAT1 orchestrates the reprogramming of lipid metabolism in ccRCC by modulating the FBXW7-mediated ubiquitination of ACLY	37
CHL1 suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin β1 and Merlin: Erratum	36
Serum amyloid A contributes to radiation-induced lung injury by activating macrophages through FPR2/Rac1/NF-κB pathway	36
TGF-β1/SMAD3-mediated Non-canonical Hedgehog Signaling Promotes Pancreatic Stellate Cell Activation and Fibrosis in Chronic Pancreatitis	36
Lactate metabolic reprogramming and histone lactylation modification in sepsis	36
MiR-375 Has Contrasting Effects on Newcastle Disease Virus Growth Depending on the Target Gene : Erratum	36
Tryptophan metabolism as a target in gut microbiota, ageing and kidney disease	36
Hepatic Stellate Cell-derived IL-11 Exacerbates Liver Fibrosis via Interplay between HSCs and Macrophages	35
The IL-33/ST2 Axis Promotes Traumatic Heterotopic Ossification by Driving Macrophage and Mast Cell-Mediated Inflammation via Autophagy Defects	35
The novel role of LOC344887 in the enhancement of hepatocellular carcinoma progression via modulation of SHP1-regulated STAT3/HMGA2 signaling axis	35
Liver X receptors and estrogen receptor β, two players in a rare subtype of NSCLC	35
Recombinant cell-penetrating trichosanthin synergizes anti-PD-1 therapy in colorectal tumor	35
FTO -induced APOE promotes the malignant progression of pancreatic neuroendocrine neoplasms through FAS	35
Integrating Subacute Ruminal Acidosis, Lipopolysaccharide, and Trained Immunity: A Comprehensive Review	34
FBXL8 Stabilizes IκBα and Negatively Regulated NF-κB Activation to Suppress Pancreatic Cancer Progression	34
O-GlcNAcylated RALY Contributes to Hepatocellular Carcinoma Cells Proliferation by Regulating USP22 mRNA Nuclear Export	34
Data-driven de novo design: revolutionizing super-adhesive hydrogels for underwater applications	34
Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation	34
BAP31-ELAVL1-SPINK6 axis induces loss of cell polarity and promotes metastasis in hepatocellular carcinoma	34
USP20, a Super-enhancer Regulated Gene, Promotes Acute Myeloid Leukemia Progression through CTNNB1 Deubiquitination	34
NDR1/FBXO11 promotes phosphorylation-mediated ubiquitination of β-catenin to suppress metastasis in prostate cancer	33
Zebrafish in Cardiovascular Disease Research: from Model to Application	33
Tumor-derived Exosomal ENO2 Modulates Polarization of Tumor-associated Macrophages through Reprogramming Glycolysis to Promote Progression of Diffuse Large B-cell Lymphoma	33
Redeemable Lymphocytes in Cancer Radioimmunotherapy: Saving Our Soldiers in the Complex of Cancer-Fighting Field	33
DUSP3 restrains the progression and stemness property of osteosarcoma through regulating EGFR/STAT3/SOX2 axis	32
Myeloid-derived Wnts play an indispensible role in macrophage and fibroblast activation and kidney fibrosis	32
Demystifying metabolic‒immune crosstalk: how amino acid metabolic reprogramming shapes the malignant phenotype and macrophage polarization of biliary and pancreatic tumors	32
Dioscin Alleviates Periodontitis by Inhibiting NLRP3 Inflammasome Activation via Regulation of K⁺ Homeostasis and Mitochondrial Function	32
Angiogenic and Fibrogenic Dual-effect of Gremlin1 on Proliferative Diabetic Retinopathy	32
Activation of GSDME by all- trans -retinal increases sensitivity to photoreceptor ferroptosis	32
ACE2 negatively regulates the Warburg effect and suppresses hepatocellular carcinoma progression via reducing ROS-HIF1α activity	32
Ferroptosis inhibitor alleviates sorafenib-induced cardiotoxicity by attenuating KLF11-mediated FSP1-dependent ferroptosis	32
ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter Methylation in Renal Cell Carcinoma	32
Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase-4/11 by LPS through lncRNA57RIK	31
Mitochondrial outer membrane protein MTUS1/ATIP1 exerts antitumor effects through ROS-induced mitochondrial pyroptosis in head and neck squamous cell carcinoma	31
FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses	31

Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP/TEAD4/ACADL axis in hepatocellular carcinoma	31
Neuropeptide substance P attenuates colitis by suppressing inflammation and ferroptosis via the cGAS-STING signaling pathway	31
Inhibition of Mettl3 alleviates low-dose cisplatin-induced renal fibrosis and enhances the chemotherapeutic efficacy in mouse models of cancer	31
PSMC5 Orchestrates an Immunosuppressive Niche and Metastasis in Colorectal Cancer via SMURF1-Mediated K11-Linked Ubiquitination of METTL14	31
TRAF2 Promotes Liver Fibrosis via Regulation of the HIF-1α/GLUT1-Mediated Glycolysis in Hepatic Stellate Cells	31
MNX1-AS1 suppresses chemosensitivity by activating the PI3K/AKT pathway in breast cancer	30
NPLOC4 Inhibition Remodels Tumor Microenvironment via M2-to-M1 Macrophage Reprogramming and Boosts Anti-PD-1 Response in Liver Cancer	30
mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice	30
FAM177A1 disrupts SIRT3-SOD2 signaling to drive mitochondrial dysfunction-mediated VSMC phenotypic switching in vascular remodeling	30
Metabolic Adaptation of CD8⁺ T Cells Limits the Efficacy of Fatty Acid Oxidation Inhibition in Type 1 Diabetes	30
Comprehensive analytical approach identifies a subtype of CTCF+ tumor-associated neutrophils associated with CRC development and as a biomarker for immunotherapy	30
RNF2 Modulates Lipid Metabolism and Inflammation in Alcohol-associated Liver Disease by Interacting with USP7	30
Hino-Fe Chelate Suppresses Osteosarcoma Progression through Dual Induction of Ferroptosis and NLRC4-mediated Pyroptosis: Mechanisms and Therapeutic Implications	29
A novel mouse model of heart failure with preserved ejection fraction after chronic kidney disease induced by retinol through JAK/STAT pathway	29
LINC-EPS Protects Against Neurodegeneration by Driving a PGC-1α-Mediated Anti-Ferroptosis Program in Parkinson's Disease	29
Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway: Erratum	29
The developmental regulator HAND1 inhibits gastric carcinogenesis through enhancing ER stress apoptosis via targeting CHOP and BAK which is augmented by cisplatin	29
Branch Chain Amino Acid Metabolism Promotes Brain Metastasis of NSCLC through EMT Occurrence by Regulating ALKBH5 activity	29
PYGL-mediated glucose metabolism reprogramming promotes EMT phenotype and metastasis of pancreatic cancer	29
Bridging Chronic Inflammation and Digestive Cancer: The Critical Role of Innate Lymphoid Cells in Tumor Microenvironments	28
The biological mechanism and emerging therapeutic interventions of liver aging	28
Activation of sphingosine-1-phosphate receptors can relieve myocardial ischemia-reperfusion injury by mitigating oxidative stress and ferroptosis in cardiomyocytes	28
Glycosylation Targeting: A Paradigm Shift in Cancer Immunotherapy	28
VRK1/BANF1/GLI1 Axis Regulates Tumor Development and Progression of Colorectal Cancer	28
TTC7B triggers the PI4KA-AKT1-RXRA-FTO axis and inhibits colon cancer cell proliferation by increasing RNA methylation	28
Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice	28
YBX1/CD36 positive feedback loop: novel molecular target for MASLD treatment	28
ISG15 Promotes Progression and Gemcitabine Resistance of Pancreatic Cancer Cells Through ATG7	28
Unraveling the breast cancer tumor microenvironment: crucial factors influencing natural killer cell function and therapeutic strategies	28
Targeting Myeloid FoxO1 Ameliorates Sepsis-induced Intestinal Injury by Modulating Tim4 ⁺ Macrophage Glycolysis	27
BAY11-7082 Targets RNF25 to Reverse TRIP4 Ubiquitination-dependent NF-κB Activation and Apoptosis Resistance in Renal Cell Carcinoma	27
SRGN-mediated reactivation of the YAP/CRISPLD2 axis promotes aggressiveness of hepatocellular carcinoma	27
The mitochondrial protein YME1 Like 1 is important for non-small cell lung cancer cell growth	27
The emerging roles of metabolism in the crosstalk between breast cancer cells and tumor-associated macrophages	27
Serine/threonine kinase 3 promotes oxidative stress and mitochondrial damage in septic cardiomyopathy through inducing Kelch-like ECH-associated protein 1 phosphorylation and nuclear factor erythroid	26
N⁶-methyladenosine Reader IGF2BP2-modified HMMR Promotes Non-small Cell Lung Cancer Metastasis via Interaction with MAP4K4	26
FKBP10 Promotes the Muscle Invasion of Bladder Cancer via Lamin A Dysregulation	26
Exploration of spatial heterogeneity of tumor microenvironment in nasopharyngeal carcinoma via transcriptional digital spatial profiling	26
HIF-1α/YAP Signaling Rewrites Glucose/Iodine Metabolism Program to Promote Papillary Thyroid Cancer Progression	26
YY1 Lactylation Elicits CARD9 Deficiency in Dendritic Cells Promoting Pancreatic Cancer Immune Escape	26
Potential Roles and Mechanisms of Curcumin and its Derivatives in the Regulation of Ferroptosis	26
The m-TORC1 inhibitor Sirolimus increases the effectiveness of Photodynamic therapy in the treatment of cutaneous Squamous Cell Carcinoma, impairing NRF2 antioxidant signaling	26
SRSF1-mediated alternative splicing is required for spermatogenesis	26
Immunologic Combinations in Multiple Myeloma: Synergistic Stimulation with T cells and NK cells	26
Decoding Epigenetic Switches: How Histone Acetylation/Deacetylation Regulates Mononuclear/Macrophage Fate in Bone Disorders	25
ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones	25
The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks	25
Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs	25
The role of gut microbiota in T cell immunity and immune mediated disorders	25
Stabilization of OLFML1 via m⁶A Reader IGF2BP3 Drives CSC Characteristics Through Hedgehog Pathway Activation in CRC	25
Epigenetic modulations of immune cells: from normal development to tumor progression	25
Emerging Progress of RNA-Based Antitumor Therapeutics	25
Dysfunction of STING Autophagy Degradation in Senescent Nucleus Pulposus Cells Accelerates Intervertebral Disc Degeneration	25
TPL2 Promotes Gastric Cancer Progression and Chemoresistance Through a Hypoxia-Induced Positive Feedback Loop with PPARδ	25
Integrative alternative splicing analysis reveals new prognosis signature in B-cell acute lymphoblastic leukemia	25
Pyroptotic Macrophage-Derived Microvesicles Accelerate Formation of Neutrophil Extracellular Traps via GSDMD-N-expressing Mitochondrial Transfer during Sepsis	25
The KLF4/Galectin-3 cascade is a key determinant of tubular cell death and acute kidney injury	25
Chronic Stress-induced Serotonin Impairs Intestinal Epithelial Cell Mitochondrial Biogenesis via the AMPK-PGC-1α Axis	25
G3BP1 Interact with JAK2 mRNA to Promote the Malignant Progression of Nasopharyngeal Carcinoma via Activating JAK2/STAT3 Signaling Pathway	24
Role of Copper Homeostasis and Cuproptosis in Cardiovascular Disease: Molecular Insights and Metabolic Perspectives	24
11β-Hydroxysteroid Dehydrogenase Type 1 Facilitates Osteoporosis by Turning on Osteoclastogenesis through Hippo Signaling	24
VCAN Is Essential for ERK5-Driven Tumorigenesis in Soft Tissue Sarcoma	24
The Therapeutic Potential of EGCG and Pro-EGCG in Mitigating Ovarian Hyperstimulation Syndrome: Unraveling the Modulatory Mechanism through the VEGF Pathway	24
Irf7 Deficiency Confers Protection Against Influenza Infection, Independent of irf3	24
The SOX10-ACAT2-Cholesterol Synthesis Axis Is Required for Melanoma Proliferation	24
Selectively targeting BCL6 using a small molecule inhibitor is a potential therapeutic strategy for ovarian cancer	24
KLF7 promotes colon adenocarcinoma progression through the PDGFB signaling pathway	24
O-glycosylation in Cancer: Emerging Paradigms and Prospects for Precision Oncology	24
Disrupting DDB2-DNA Interaction by Lapatinib Enhances Chemotherapy Sensitivity	24
Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects	24
Nuclear Galectin-1 Drives Cancer Progression through O -GlcNAcylation-Dependent Regulation of SOX2	23
BGN/FAP/STAT3 positive feedback loop mediated mutual interaction between tumor cells and mesothelial cells contributes to peritoneal metastasis of gastric cancer	23
Extracellular vesicles derived from irradiated tumor cells foster immunosuppressive macrophages formation to promote esophageal squamous cell carcinoma immune evasion	23
O-GlcNAcylated Hsp47 as a predictive biomarker in colorectal cancer: Kaempferol targets OGT-collagen axis for therapeutic intervention	23
Novel Insights into The Roles of N⁶-methyladenosine (m⁶A) Modification and Autophagy in Human Diseases	23
Antcin K ameliorates cardiotoxin-induced skeletal muscle injury and inflammation via IL-10 regulation	23
M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets	23
IκB kinase β (IKKβ): Structure, transduction mechanism, biological function, and discovery of its inhibitors	23
Inhibition of KMO Ameliorates Myocardial Ischemia Injury via Maintaining Mitochondrial Fusion and Fission Balance	23
Mesangial Cells in Diabetic Kidney Disease: From Mechanisms to Therapeutic Implications	23
Folic Acid-Modified Milk Exosomes Delivering c-Kit siRNA Overcome EGFR-TKIs Resistance in Lung Cancer by Suppressing mTOR Signaling and Stemness	23
PGK1 Regulates Oxidative Stress in Gestational Diabetes Mellitus through the Estradiol-Keap1-Nrf2 Pathway	23
APOL3-LDHA axis related immunity activation and cancer ferroptosis induction	23
Molecular Modulators and Receptors of Selective Autophagy: Disease Implication and Identification Strategies	23
The TRPM7 inhibitor carvacrol suppresses angiogenesis and vasculogenic mimicry in triple-negative breast cancer	23
Integrative Single-Cell and Spatial Transcriptomics Analysis Reveals ECM-remodeling Cancer-associated Fibroblast-Derived POSTN as a Key Mediator in Pancreatic Ductal Adenocarcinoma Progression	23
Genome-wide binding analysis unveils critical implication of B-Myb-mediated transactivation in cancers	23
Cardiomyocyte GSDME Drives Doxorubicin-Induced Cardiotoxicity by Targeting the CCL2-CCR2 Axis	23
PTEN-deficient, chromosomal instability colorectal cancer is hypersensitive to STAT3 inhibition	22
The Essential Role of Angiogenesis in Adenosine 2A Receptor Deficiency-mediated Impairment of Wound Healing Involving c-Ski via the ERK/CREB Pathways	22
Dysregulation of SRSF3/circSAMD4/CIRBP Axis Promotes Iodinated Contrast-induced Acute Kidney Injury	22
eNAMPT/Ac-STAT3/DIRAS2 Axis Promotes Development and Cancer Stemness in Triple-Negative Breast Cancer by Enhancing Cytokine Crosstalk Between Tumor-Associated Macrophages and Cancer Cells	22
Microbiota-gut-kidney axis in health and renal disease	22
Impact of rare JAK/STAT germline mutations on vaccination-induced innate immune responses in a Tyrolian population	22
Activated AXL Ameliorates Alcohol-associated Steatotic Liver Ischemia-Reperfusion Injury by Inhibiting ER stress and Mitochondria-associated Apoptosis	22