International Journal of Biological Sciences

Article	Citations
p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer	240
MKL-1 suppresses ferroptosis by activating system Xc- and increasing glutathione synthesis	212
The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis In Vitro and In Vivo	205
Reconstruction of the Hepatic Microenvironment and Pathological Changes Underlying Type II Diabetes through Single-Cell RNA Sequencing	194
A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer	184
Digging out MDIG from the mess of H3K9me3, OTX2 and MYC signaling in human cancers	175
Loss of DDRGK1 impairs IRE1α UFMylation in spondyloepiphyseal dysplasia	147
Exosomes: a promising microenvironment modulator for spinal cord injury treatment	145
Mechanistic role of metal-responsive transcription factor-1 (MTF-1) in cadmium-induced prostate carcinogenesis	137
Comprehensive Histopathology Imaging in Pancreatic Biopsies: High Definition Infrared Imaging with Machine Learning Approach	136
The dysadherin/FAK axis promotes individual cell migration in colon cancer	134
PPDPF Promotes the Progression and acts as an Antiapoptotic Protein in Non-Small Cell Lung Cancer	133
COVID-19 receptor and malignant cancers: Association of CTSL expression with susceptibility to SARS-CoV-2	125
Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers	116
Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma	114
Extracellular vesicles, the emerging mirrors of brain physiopathology	113
As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma	111
Pathogenesis and treatment strategies of sepsis-induced myocardial injury: modern and traditional medical perspectives	109
Cancer-associated fibroblasts promote migration and invasion of non-small cell lung cancer cells via METTL3-mediated RAC3 m6A modification	109
TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver disease via nitric oxide production	104
Nlp-dependent ER-to-Golgi transport	104
SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway	104
Dysregulated Ribosome Biogenesis Is a Targetable Vulnerability in Triple-Negative Breast Cancer: MRPS27 as a Key Mediator of the Stemness-inhibitory Effect of Lovastatin	102
RNA-binding motif protein 10 represses tumor progression through the Wnt/β- catenin pathway in lung adenocarcinoma	98
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells	95

SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer	94
P2RY13 Exacerbates Intestinal Inflammation by Damaging the Intestinal Mucosal Barrier via Activating IL-6/STAT3 Pathway	90
Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma	85
Antioxidant genes in cancer and metabolic diseases: Focusing on Nrf2, Sestrin, and heme oxygenase 1	85
Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice	81
Inhibition of the HMGB1/RAGE axis protects against cisplatin-induced ototoxicity via suppression of inflammation and oxidative stress	79
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases	78
Regulation of lung epithelial cell senescence in smoking-induced COPD/emphysema by microR-125a-5p via Sp1 mediation of SIRT1/HIF-1a	78
TBX21 inhibits colorectal cancer metastasis through ARHGAP29/GSK3β inhibitory signaling- and MYCT1/ZO-1 signaling-dependent manner	75
CD151 promotes Colorectal Cancer progression by a crosstalk involving CEACAM6, LGR5 and Wnt signaling via TGFβ1: Erratum	73
Glycine Decarboxylase Regulates Renal Carcinoma Progression via Interferon Stimulated Gene Factor 3-Mediated Pathway	73
TRIM37 Augments AP-2γ Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression	71
Cardiovascular-related proteomic changes in ECFCs exposed to the serum of COVID-19 patients	71
PROX1-mediated epigenetic silencing of SIRT3 contributes to proliferation and glucose metabolism in colorectal cancer	70
Activation of central Angiotensin-(1-7)/Mas receptor alleviates synaptic damage in diabetes-associated cognitive impairment via modulating AKT/FOXO1/PACAP axis	70
The role of RGC degeneration in the pathogenesis of glaucoma	68
HNRNPK/CLCN3 axis facilitates the progression of LUAD through CAF-tumor interaction	67
RNA methylation-mediated LINC01559 suppresses colorectal cancer progression by regulating the miR-106b-5p/PTEN axis	65
Targeting Necroptosis: A Novel Therapeutic Option for Retinal Degenerative Diseases	65
The Crosstalk between Autophagy and Nrf2 Signaling in Cancer: from Biology to Clinical Applications	64
Mannan-Binding Lectin Deficiency Limits Inflammation-induced Myeloid-Derived Suppressor Cells Expansion via Modulating Tumor Necrosis Factor Alpha-triggered Apoptosis	64
PSMC6 regulation of ovarian cancer cisplatin resistance unravels a new mode for proteasome targeting	63
The Novel Role of hnRNP UL1 in Human Cell Nucleoli	62
Ugonin P mitigates osteolytic bone metastasis by suppressing MDK via upregulating miR-223-3p expression	62
C3G down-regulation enhances pro-migratory and stemness properties of oval cells by promoting an epithelial-mesenchymal-like process	61
Identification of Gαi3 as a promising target for osteosarcoma treatment	60
N-Acetylcysteine Alleviates Depressive-Like Behaviors in Adolescent EAAC1-/- Mice and Early Life Stress Model Rats	60
Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1	59
Dual-specificity tyrosine-regulated kinase 4 modulates the STAT3-FOS signaling axis to inhibit hepatitis B virus replication via autophagy	59
IL-6/STAT3 Axis Activates Glut5 to Regulate Fructose Metabolism and Tumorigenesis	57
Treatment for type 2 diabetes and diabetic nephropathy by targeting Smad3 signaling	57
Ferroptosis-associated molecular classification characterized by distinct tumor microenvironment profiles in colorectal cancer	57
IL-38 Aggravates Atopic Dermatitis via Facilitating Migration of Langerhans cells	56
Oxidative stress promotes liver fibrosis by modulating the microRNA-144 and SIN3A-p38 pathways in hepatic stellate cells	55
1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice	54
NUF2 Drives Cholangiocarcinoma Progression and Migration via Inhibiting Autophagic Degradation of TFR1	53
Irisin attenuates vascular remodeling in hypertensive mice induced by Ang II by suppressing Ca2+-dependent endoplasmic reticulum stress in VSMCs	53
Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis	52
tRF-27 competitively Binds to G3BPs and Activates MTORC1 to Enhance HER2 Positive Breast Cancer Trastuzumab Tolerance	52
Immunosenescence, Physical Exercise, and their Implications in Tumor Immunity and Immunotherapy	52
Extracellular Vesicles in Mental Disorders: A State-of-art Review	52
Metabolomics reveals that CAF-derived lipids promote colorectal cancer peritoneal metastasis by enhancing membrane fluidity	52
m6A RNA methylation drives kidney fibrosis by upregulating β-catenin signaling	52
Methyltransferase Set7/9 as a Multifaceted Regulator of ROS Response	52
ITGB4 deficiency induces mucus hypersecretion by upregulating MUC5AC in RSV-infected airway epithelial cells	51
TSG-6 promotes Cancer Cell aggressiveness in a CD44-Dependent Manner and Reprograms Normal Fibroblasts to create a Pro-metastatic Microenvironment in Colorectal Cancer	51
Neurotrophin3 promotes hepatocellular carcinoma apoptosis through the JNK and P38 MAPK pathways	51
Theophylline derivatives promote primordial follicle activation via cAMP-PI3K/Akt pathway and ameliorate fertility deficits in naturally aged mice	51
Coenzyme Q0 inhibited the NLRP3 inflammasome, metastasis/EMT, and Warburg effect by suppressing hypoxia-induced HIF-1α expression in HNSCC cells	51
Traditional Chinese Medicine JingYinGuBiao Formula Therapy Improves the Negative Conversion Rate of SARS-CoV2 in Patients with Mild COVID-19	51

Comprehensive Analyses Reveal Effects on Tumor Immune Infiltration and Immunotherapy Response of APOBEC Mutagenesis and Its Molecular Mechanisms in Esophageal Squamous Cell Carcinoma	49
Towards a “Testis in a Dish”: Generation of Mouse Testicular Organoids that Recapitulate Testis Structure and Expression Profiles	49
Paris saponin VII reverses resistance to PARP inhibitors by regulating ovarian cancer tumor angiogenesis and glycolysis through the RORα/ECM1/VEGFR2 signaling axis	48
IKBKE regulates renal cell carcinoma progression and sunitinib resistance through the RRM2-AKT pathway	48
Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy	48
METTL18 functions as a Phenotypic Regulator in Src-Dependent Oncogenic Responses of HER2-Negative Breast Cancer	48
Inhibition of APOE potentiates immune checkpoint therapy for cancer	48
Polysaccharide isolated from Grifola frondosa eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T cells responses	48
Serum amyloid A contributes to radiation-induced lung injury by activating macrophages through FPR2/Rac1/NF-κB pathway	46
miR-199a-3p/5p regulate tumorgenesis via targeting Rheb in non-small cell lung cancer: Erratum	46
Therapeutic implications for localized prostate cancer by multiomics analyses of the ageing microenvironment landscape	46
G against Glioma: G protein inhibitory α subunit 2 (Gαi2) as a novel glioma target	46
RUNX1-PDIA5 Axis Promotes Malignant Progression of Glioblastoma by Regulating CCAR1 Protein Expression	46
PARP inhibitor augments anti-tumor efficacy of DNMT inhibitor by inducing senescence in cholangiocarcinoma	46
CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways: Erratum	45
The E3 ubiquitin ligase MAEA promotes macrophage phagocytosis and inhibits gastrointestinal cancer progression by mediating PARP1 ubiquitination and degradation	45
NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer: Retraction	45
Targeting ALG3/FOXD1/BNIP3 Axis Prevents Mitophagy and Gemcitabine Resistance of Nasopharyngeal Carcinoma	45
Customized liver organoids as an advanced in vitro modeling and drug discovery platform for non-alcoholic fatty liver diseases	44
Tryptophan metabolism as a target in gut microbiota, ageing and kidney disease	44
Neferine Ameliorates Severe Acute Pancreatitis-Associated Intestinal Injury by Promoting NRF2-mediated Ferroptosis	44
Inhibition of GRK2-PDE4D Axis Suppresses Fibroblast-Like Synoviocytes Hyperplasia and Alleviates Experimental Arthritis	44
The TTYH3/MK5 Positive Feedback Loop regulates Tumor Progression via GSK3-β/β-catenin signaling in HCC	44
Optimizing the dynamic zero-COVID policy in China	44
CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA	43
HIF-2α/LPCAT1 orchestrates the reprogramming of lipid metabolism in ccRCC by modulating the FBXW7-mediated ubiquitination of ACLY	43
Recent Trends in anti-tumor mechanisms and molecular targets of celastrol	43
A positive feedback loop of CENPU/E2F6/E2F1 facilitates proliferation and metastasis via ubiquitination of E2F6 in hepatocellular carcinoma: Erratum	43
Tumor-associated macrophages in direct contact with prostate cancer cells promote malignant proliferation and metastasis through NOTCH1 pathway	43
The Effects and Mechanisms of Flavonoids on Cancer Prevention and Therapy: Focus on Gut Microbiota	42
Androgen receptor suppresses lung cancer invasion and increases cisplatin response via decreasing TPD52 expression	42
ALKBH5 Promotes Multiple Myeloma Tumorigenicity through inducing m6A-demethylation of SAV1 mRNA and Myeloma Stem Cell Phenotype	42
Development and application of ribonucleic acid therapy strategies against COVID-19	42
REIA: A database for cancer A-to-I RNA editing with interactive analysis	41
TEAD1 Prevents Necroptosis and Inflammation in Cisplatin-Induced Acute Kidney Injury Through Maintaining Mitochondrial Function	41
Eukaryotic ribosome quality control system: a potential therapeutic target for human diseases	41
Paclitaxel treatment enhances lymphatic metastasis of B16F10 melanoma cells via CCL21/CCR7 axis	41
Targeting Ferroptosis by Ubiquitin System Enzymes: A Potential Therapeutic Strategy in Cancer	41
Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea	41
The advanced glycation end-products (AGEs)/ROS/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound healing and nerve regeneration	41
miR-199a-3p/5p regulate tumorgenesis via targeting Rheb in non-small cell lung cancer	41
Emerging Role of Ferroptosis in Diabetic Kidney Disease: Molecular Mechanisms and Therapeutic Opportunities	40
The FTO-CMPK2 Pathway in Fibroblast-like Synoviocytes Modulates Rheumatoid Arthritis Synovial Inflammation and Cartilage Homeostasis via mtDNA Regulation	40
Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury	40
The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer	40
The Role of Thrombospondins in Osteoarthritis: from Molecular Mechanisms to Therapeutic Potential	39
BRD7 enhances the radiosensitivity of nasopharyngeal carcinoma cells by negatively regulating USP5/METTL3 axis-mediated homologous recombination repair	39
Reprogramming of Lipid Metabolism Mediates Crosstalk, Remodeling, and Intervention of Microenvironment Components in Breast Cancer	39
Cisplatin-induced Pyroptosis Enhances the Efficacy of PD-L1 Inhibitor in Small-Cell Lung Cancer via GSDME/IL12/CD4Tem Axis	39
Melatonin modulates the hypothalamic-pituitary neuroendocrine axis to regulate physiological color change in teleost fish	39
Interruption of p38MAPK-MSK1-CREB-MITF-M pathway to prevent hyperpigmentation in the skin	39
UPP1 enhances bladder cancer progression and gemcitabine resistance through AKT	38
BAP31-ELAVL1-SPINK6 axis induces loss of cell polarity and promotes metastasis in hepatocellular carcinoma	38
CHL1 suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin β1 and Merlin: Erratum	38
Establishment and Validation of an Interferon-Stimulated Genes (ISGs) Prognostic Signature in Pan-cancer Patients: A Multicenter, Real-world Study	38
MiR-375 Has Contrasting Effects on Newcastle Disease Virus Growth Depending on the Target Gene : Erratum	38
Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling	38
Angiogenic and Fibrogenic Dual-effect of Gremlin1 on Proliferative Diabetic Retinopathy	38
DUSP3 restrains the progression and stemness property of osteosarcoma through regulating EGFR/STAT3/SOX2 axis	38
Integrating Subacute Ruminal Acidosis, Lipopolysaccharide, and Trained Immunity: A Comprehensive Review	37
Emerging Mechanisms and Targeted Therapy of Ferroptosis in Neurological Diseases and Neuro-oncology	37
Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation	37
Liver X receptors and estrogen receptor β, two players in a rare subtype of NSCLC	37
Recombinant cell-penetrating trichosanthin synergizes anti-PD-1 therapy in colorectal tumor	37
RNF2 Modulates Lipid Metabolism and Inflammation in Alcohol-associated Liver Disease by Interacting with USP7	37
The novel role of LOC344887 in the enhancement of hepatocellular carcinoma progression via modulation of SHP1-regulated STAT3/HMGA2 signaling axis	37
O-GlcNAcylated RALY Contributes to Hepatocellular Carcinoma Cells Proliferation by Regulating USP22 mRNA Nuclear Export	36
Mitochondrial outer membrane protein MTUS1/ATIP1 exerts antitumor effects through ROS-induced mitochondrial pyroptosis in head and neck squamous cell carcinoma	36
Inhibition of Mettl3 alleviates low-dose cisplatin-induced renal fibrosis and enhances the chemotherapeutic efficacy in mouse models of cancer	36
ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter Methylation in Renal Cell Carcinoma	36
FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses	36
ACE2 negatively regulates the Warburg effect and suppresses hepatocellular carcinoma progression via reducing ROS-HIF1α activity	36
Pyroptotic cell death in SARS-CoV-2 infection: revealing its roles during the immunopathogenesis of COVID-19	35
Dioscin Alleviates Periodontitis by Inhibiting NLRP3 Inflammasome Activation via Regulation of K+ Homeostasis and Mitochondrial Function	35
Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase-4/11 by LPS through lncRNA57RIK	35
Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury	35
The role of DNA mismatch repair in immunotherapy of human cancer	35
NDR1/FBXO11 promotes phosphorylation-mediated ubiquitination of β-catenin to suppress metastasis in prostate cancer	34
Myeloid-derived Wnts play an indispensible role in macrophage and fibroblast activation and kidney fibrosis	34
Neuropeptide substance P attenuates colitis by suppressing inflammation and ferroptosis via the cGAS-STING signaling pathway	34

Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP/TEAD4/ACADL axis in hepatocellular carcinoma	34
mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice	34
Ferroptosis inhibitor alleviates sorafenib-induced cardiotoxicity by attenuating KLF11-mediated FSP1-dependent ferroptosis	34
Integrated Machine Learning and Bioinformatic Analyses Constructed a Novel Stemness-Related Classifier to Predict Prognosis and Immunotherapy Responses for Hepatocellular Carcinoma Patients	34
Tumor-derived Exosomal ENO2 Modulates Polarization of Tumor-associated Macrophages through Reprogramming Glycolysis to Promote Progression of Diffuse Large B-cell Lymphoma	34
SRSF1-mediated alternative splicing is required for spermatogenesis	33
Emerging Progress of RNA-Based Antitumor Therapeutics	33
FKBP10 Promotes the Muscle Invasion of Bladder Cancer via Lamin A Dysregulation	33
A novel mouse model of heart failure with preserved ejection fraction after chronic kidney disease induced by retinol through JAK/STAT pathway	33
TRIM44 promotes BRCA1 functions in HR repair to induce Cisplatin Chemoresistance in Lung Adenocarcinoma by Deubiquitinating FLNA	33
Glycosylation Targeting: A Paradigm Shift in Cancer Immunotherapy	33
N6-methyladenosine Reader IGF2BP2-modified HMMR Promotes Non-small Cell Lung Cancer Metastasis via Interaction with MAP4K4	33
TTC7B triggers the PI4KA-AKT1-RXRA-FTO axis and inhibits colon cancer cell proliferation by increasing RNA methylation	33
HERC3 directly targets RPL23A for ubiquitination degradation and further regulates Colorectal Cancer proliferation and the cell cycle	32
PYGL-mediated glucose metabolism reprogramming promotes EMT phenotype and metastasis of pancreatic cancer	32
The role of gut microbiota in T cell immunity and immune mediated disorders	32
Dysfunction of STING Autophagy Degradation in Senescent Nucleus Pulposus Cells Accelerates Intervertebral Disc Degeneration	32
GALNT1 Enhances Malignant Phenotype of Gastric Cancer via Modulating CD44 Glycosylation to Activate the Wnt/β-catenin Signaling Pathway	32
Pyroptotic Macrophage-Derived Microvesicles Accelerate Formation of Neutrophil Extracellular Traps via GSDMD-N-expressing Mitochondrial Transfer during Sepsis	32
HIF-1α/YAP Signaling Rewrites Glucose/Iodine Metabolism Program to Promote Papillary Thyroid Cancer Progression	31
Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs	31
Branch Chain Amino Acid Metabolism Promotes Brain Metastasis of NSCLC through EMT Occurrence by Regulating ALKBH5 activity	31
Bridging Chronic Inflammation and Digestive Cancer: The Critical Role of Innate Lymphoid Cells in Tumor Microenvironments	31
Serine/threonine kinase 3 promotes oxidative stress and mitochondrial damage in septic cardiomyopathy through inducing Kelch-like ECH-associated protein 1 phosphorylation and nuclear factor erythroid	31
Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway: Erratum	31
Potential Roles and Mechanisms of Curcumin and its Derivatives in the Regulation of Ferroptosis	30
VRK1/BANF1/GLI1 Axis Regulates Tumor Development and Progression of Colorectal Cancer	30
The m-TORC1 inhibitor Sirolimus increases the effectiveness of Photodynamic therapy in the treatment of cutaneous Squamous Cell Carcinoma, impairing NRF2 antioxidant signaling	30
CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability	30
Chronic Stress-induced Serotonin Impairs Intestinal Epithelial Cell Mitochondrial Biogenesis via the AMPK-PGC-1α Axis	30
Diverse Ras-related GTPase DIRAS2, downregulated by PSMD2 in a proteasome-mediated way, inhibits colorectal cancer proliferation by blocking NF-κB signaling	30
The mitochondrial protein YME1 Like 1 is important for non-small cell lung cancer cell growth	30
miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3γ in early stage of 5xFAD mouse model of Alzheimer's disease	30
MNX1-AS1 suppresses chemosensitivity by activating the PI3K/AKT pathway in breast cancer	30
Ability of Local Clearance of Senescent Cells in Ipsilateral Hemisphere to Mitigate Acute Ischemic Brain Injury in Mice	29
The biological mechanism and emerging therapeutic interventions of liver aging	29
Ursolic Acid Derivative UA232 Promotes Tumor Cell Apoptosis by Inducing Endoplasmic Reticulum Stress and Lysosomal Dysfunction	29
CpG-C ODN M362 as an immunoadjuvant for HBV therapeutic vaccine reverses the systemic tolerance against HBV	29
Unraveling the breast cancer tumor microenvironment: crucial factors influencing natural killer cell function and therapeutic strategies	29
M2 Macrophage Derived Extracellular Vesicle-Mediated Transfer of MiR-186-5p Promotes Colon Cancer Progression by Targeting DLC1	29
The emerging roles of metabolism in the crosstalk between breast cancer cells and tumor-associated macrophages	29
Identification of Gαi3 as a novel molecular therapeutic target of cervical cancer	29
Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19	28
Targeting HMGB1: An available Therapeutic Strategy for Breast Cancer Therapy	28
LncRNA FAM83A-AS1 facilitates tumor proliferation and the migration via the HIF-1α/ glycolysis axis in lung adenocarcinoma	28
Role of Non-coding RNAs in Axon Regeneration after Peripheral Nerve Injury	28
Natural tannins as anti-SARS-CoV-2 compounds	28
Epigenetic modulations of immune cells: from normal development to tumor progression	28
Genome-wide binding analysis unveils critical implication of B-Myb-mediated transactivation in cancers	28
The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks	28
SRGN-mediated reactivation of the YAP/CRISPLD2 axis promotes aggressiveness of hepatocellular carcinoma	28
The developmental regulator HAND1 inhibits gastric carcinogenesis through enhancing ER stress apoptosis via targeting CHOP and BAK which is augmented by cisplatin	28
ISG15 Promotes Progression and Gemcitabine Resistance of Pancreatic Cancer Cells Through ATG7	28
Exploration of spatial heterogeneity of tumor microenvironment in nasopharyngeal carcinoma via transcriptional digital spatial profiling	28
Polystyrene Nanoplastics Exacerbate HFD-induced MASLD by Reducing Cathepsin Activity and Triggering Large Vacuole Formation via Impaired Lysosomal Acidification	27
MiR-216a-5p inhibits tumorigenesis in Pancreatic Cancer by targeting TPT1/mTORC1 and is mediated by LINC01133: Erratum	27
Novel Insights into The Roles of N6-methyladenosine (m6A) Modification and Autophagy in Human Diseases	27
Integrative alternative splicing analysis reveals new prognosis signature in B-cell acute lymphoblastic leukemia	27
MiR-17-5p and MKL-1 modulate stem cell characteristics of gastric cancer cells: Erratum	27
Activated AXL Ameliorates Alcohol-associated Steatotic Liver Ischemia-Reperfusion Injury by Inhibiting ER stress and Mitochondria-associated Apoptosis	27
The Therapeutic Potential of EGCG and Pro-EGCG in Mitigating Ovarian Hyperstimulation Syndrome: Unraveling the Modulatory Mechanism through the VEGF Pathway	27
IKZF1 selectively enhances homologous recombination repair by interacting with CtIP and USP7 in multiple myeloma	27
APOL3-LDHA axis related immunity activation and cancer ferroptosis induction	27
Integrative Single-Cell and Spatial Transcriptomics Analysis Reveals ECM-remodeling Cancer-associated Fibroblast-Derived POSTN as a Key Mediator in Pancreatic Ductal Adenocarcinoma Progression	27
Antcin K ameliorates cardiotoxin-induced skeletal muscle injury and inflammation via IL-10 regulation	27
G3BP1 Interact with JAK2 mRNA to Promote the Malignant Progression of Nasopharyngeal Carcinoma via Activating JAK2/STAT3 Signaling Pathway	27
Stabilization of OLFML1 via m6A Reader IGF2BP3 Drives CSC Characteristics Through Hedgehog Pathway Activation in CRC	26
ER translocon inhibitor ipomoeassin F inhibits triple-negative breast cancer growth via blocking ER molecular chaperones	26
Deubiquitinases in Ovarian Cancer: Role in Drug Resistance and Tumor Aggressiveness	26
PROX1 promotes breast cancer invasion and metastasis through WNT/β-catenin pathway via interacting with hnRNPK	26
A Novel ER Stress Mediator TMTC3 Promotes Squamous Cell Carcinoma Progression by Activating GRP78/PERK Signaling Pathway	26
Folic Acid-Modified Milk Exosomes Delivering c-Kit siRNA Overcome EGFR-TKIs Resistance in Lung Cancer by Suppressing mTOR Signaling and Stemness	26
Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects	26
Current Status in Rechallenge of Immunotherapy	26
M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets	26
11β-Hydroxysteroid Dehydrogenase Type 1 Facilitates Osteoporosis by Turning on Osteoclastogenesis through Hippo Signaling	26
BGN/FAP/STAT3 positive feedback loop mediated mutual interaction between tumor cells and mesothelial cells contributes to peritoneal metastasis of gastric cancer	26
Inhibition of KMO Ameliorates Myocardial Ischemia Injury via Maintaining Mitochondrial Fusion and Fission Balance	26
Targeting ACLY efficiently inhibits SARS-CoV-2 replication	25
IκB kinase β (IKKβ): Structure, transduction mechanism, biological function, and discovery of its inhibitors	25
Molecular Modulators and Receptors of Selective Autophagy: Disease Implication and Identification Strategies	25
BMI1 promotes spermatogonial stem cell maintenance by epigenetically repressing Wnt10b/β-catenin signaling	25
Novel insight into metabolic reprogrammming in cancer radioresistance: A promising therapeutic target in radiotherapy	25
Mitochondrial quality control in diabetic cardiomyopathy: from molecular mechanisms to therapeutic strategies	25
METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway	25
KLF7 promotes colon adenocarcinoma progression through the PDGFB signaling pathway	25
Intermittent Fasting Attenuates Hallmark Vascular and Neuronal Pathologies in a Mouse Model of Vascular Cognitive Impairment	25
Apelin Prevents and Alleviates Crystalline Silica-induced Pulmonary Fibrosis via Inhibiting Transforming Growth Factor Beta 1-triggered Fibroblast Activation	25
A SIX1 degradation inducer blocks excessive proliferation of prostate cancer	25
Selectively targeting BCL6 using a small molecule inhibitor is a potential therapeutic strategy for ovarian cancer	25
Immunologic Memory in Pregnancy: Focusing on Memory Regulatory T Cells	25
Myeloid cell-expressed MNDA enhances M2 polarization to facilitate the metastasis of hepatocellular carcinoma	24
Neuraminidase 1 deficiency attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory via AMPK-SIRT3 pathway in diabetic cardiomyopathy mice	24
Enhancing CAR-T Cell Metabolic Fitness and Memory Phenotype for Improved Efficacy against Hepatocellular Carcinoma	24
Uncovering the flip side of immune checkpoint inhibitors: a comprehensive review of immune-related adverse events and predictive biomarkers	24