Nature Cell Biology

Article	Citations
Pushing chromatin to totipotency	798
STING and fat crosstalk	548
Enhancing T cell therapy	422
Unravelling the endoplasmic reticulum–Golgi intermediate compartment in plant cells	314
Keeping membraneless organelles apart	243
tRNA flux and consistency in differentiation	240
COPIng with senescence	214
Restoring placental methylome	204
Compression-dependent microtubule reinforcement enables cells to navigate confined environments	199
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ	195
Atlas of amnion development during the first trimester of human pregnancy	184
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription	171
Finding a chaperone for TDP-43	164
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources	163
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication	157
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells	157
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage	155
The guinea pig serves as an alternative model to study human preimplantation development	152
RIPK1 and RIPK3 form mosaic necrosomes	150
ER-associated RNA silencing promotes ER quality control	149
A guideline on the molecular ecosystem regulating ferroptosis	144
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture	143
Criteria for the standardization of stem-cell-based embryo models	143
Telomere dysfunction in ageing and age-related diseases	142
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function	140

How a ribosomal protein avoids mixed signals	139
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis	139
Regenerating the academic pipeline	137
Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1	134
A serendipitous discovery of a family of membrane remodelling proteins	129
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis	127
Nuclear class 3 PI3K coactivates circadian clock	127
Implementing sustainable science in the lab	126
PRC2 shields the potency of human stem cells	121
HSF1 renders NK cells too stressed to respond	116
TCF3, TCF12 and distinct enhancers regulate oocyte transcription	115
Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth	113
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells	112
A lysosomal surveillance response to stress extends healthspan	110
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation	110
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death	109
Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer	108
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate	106
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription	106
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	105
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise	105
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration	104
Real-time and programmable transcriptome sequencing with PROFIT-seq	104
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer	103
Spermidine is essential for fasting-mediated autophagy and longevity	99
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis	97
Membranes regulate biomolecular condensates	97
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis	94
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	93
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates	93
Deep-learning for microscopy	91
A cell biological perspective on Singapore’s scientific growth	90
Xist seeds X inactivation	88
Telomeres are a life-extending gift	87
Waste management and cell death in T cells	86
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome	84
A model for propagation of RNA structural memory through biomolecular condensates	84
It started with a western	83
Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs	82
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system	81
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells	80
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor	79
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth	78
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities	76
Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning	75
Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells	74
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification	73
Time for lipid cell biology	73
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling	72
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition	71

Sequential enhancer state remodelling defines human germline competence and specification	70
Tissue memory relies on stem cell priming in distal undamaged areas	70
The role of PINK1–Parkin in mitochondrial quality control	69
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope	68
Single-cell spatial transcriptomics	68
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions	68
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming	67
The transcription factor GABPA is a master regulator of naive pluripotency	67
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity	66
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair	66
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis	64
Cell-intrinsic and microenvironmental determinants of metastatic colonization	64
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness	64
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair	64
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool	64
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development	63
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity	63
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes	63
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	63
Phase separation of EB1 guides microtubule plus-end dynamics	62
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance	62
Author Correction: Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants	61
Author Correction: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation	61
Keeping up with the Rag GTPases	61
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis	60
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung	60
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis	60
Mitochondrial YME1L1 governs unoccupied protein translocase channels	59
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing	59
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma	58
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy	58
Publisher Correction: m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	58
CAF heterogeneity and dynamics	58
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes	57
Author Correction: Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	57
Multiplexed genome regulation in vivo with hyper-efficient Cas12a	57
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions	57
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux	57
Revealing the order of chromatin reorganization events with Dam&ChIC	56
The molecular basis of human transcription-coupled DNA repair	55
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division	54
Cell type ontologies of the Human Cell Atlas	54
Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis	54
A milestone in epithelial–mesenchymal transition	54
Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells	53
Autophagy-targeted NBR1–p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH	53
Lysate-based pipeline to characterize microtubule-associated proteins uncovers unique microtubule behaviours	53
CoCo-ST detects global and local biological structures in spatial transcriptomics datasets	53
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation	52
A single-cell transcriptomic landscape of the lungs of patients with COVID-19	52
Species-specific cortex features	52
Shaping the composition of the mitochondrial outer membrane	51
From phage genetics to chromosomes as mechanical objects	51
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression	51
COVID-19 lung atlas	51
Mapping T cell landscapes in B cell lymphomas	50
Conference accessibility should be a universal concern	50
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	49
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression	49
Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities	49
VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells	48
Author Correction: Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development	48
Cell origin of BRCA2-mutant breast cancer	48
Long life depends on open communication	48
Spatial transcriptomic characterization of a Carnegie stage 7 human embryo	48
ERCC6L2–CtIP condensation tunes end resection	48
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels	47
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth	47
Rear traction forces drive adherent tissue migration in vivo	47
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT	47
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion	47
A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling	47
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells	47
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis	46
Harnessing introns to monitor gene expression	46
Diet and longevity	46
Mapping paths through the nuclear pore complex	45
Arginyl-tRNA synthetase in inflammation	45
Navigating human embryogenesis through tailored model selection	45
Worrying through the ECM	45

Ribophagy relies on Rpl12	45
Metabolites in tumour interstitial fluid directly suppress T cells	45
Author Correction: Stiff matrix induces exosome secretion to promote tumour growth	45
Author Correction: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	45
The spectrin cytoskeleton integrates endothelial mechanoresponses	45
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation	44
Nuclear mechanics as a determinant of nuclear pore complex plasticity	44
In situ architecture of the human prohibitin complex	44
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases	44
CD160 dictates anti-PD-1 immunotherapy resistance by regulating CD8+ T cell exhaustion in colorectal cancer	44
A bridge-like lipid transport protein controls plasma membrane lipid composition and fluidity	42
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling	42
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis	42
NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency	42
Cracking glioblastoma core regulatory codes	41
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition	41
An expanding repertoire of E3 ligases in membrane Atg8ylation	41
Evidence for widespread cytoplasmic structuring into mesoscale condensates	41
RNA sequestration in P-bodies sustains myeloid leukaemia	41
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	41
Pausing pluripotency via RNA methylation	40
METTL3 restrains autoimmunity in β-cells	40
Order and disorder in clathrin-mediated endocytosis	40
Intrinsically disordered CO2 sensors	40
Stiff matrix induces exosome secretion to promote tumour growth	40
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis	40
Lipidomes define immune cell identity	39
FUS maintains TAZ fluidity and function	39
Neutrophil-derived migrasomes are an essential part of the coagulation system	39
Celebrating 25 years of cell biology	39
CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development	38
Lysosome lipid signalling from the periphery to neurons regulates longevity	38
Crossover patterning through condensation and coarsening of pro-crossover factors	38
A chosen STING with a PERKy trail	38
Morula-derived trophectoderm stem cells	38
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection	38
Forcing cell fate	37
Mitochondrial shape alteration by metabolites	37
Remote control of AMPK via extracellular adenosine controls tissue growth	37
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation	37
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers	37
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos	36
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity	36
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes	36
Nuclear pores safeguard the integrity of the nuclear envelope	36
Ex vivo imaging reveals the spatiotemporal control of ovulation	36
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression	35
Boosting cargo turnover with receptor mobility	35
RNA scaffolds the Golgi ribbon by forming condensates with GM130	35
Breaking up translation condensates in cancer	35
Sugar unmasking for trafficking	35
A new cell in an old tactile sensory organ	35
Human neural tube morphogenesis in a dish	35
Sperm bud mitochondria to adjust the numbers	35
Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma	34
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules	34
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins	34
Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants	34
RNA-binding proteins pull in chromatin loops	34
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation	34
Softening redox homeostasis in cancer cells	34
Harnessing lysohormesis for healthy ageing	33
Gender equity: toward redefining values	33
FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance	33
Combinatorial selective ER-phagy remodels the ER during neurogenesis	33
NAD+ regulates nucleotide metabolism and genomic DNA replication	33
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing	33
Lessons from infrastructure and research advocacy in India	32
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase	32
Retinoic acid induces human gastruloids with posterior embryo-like structures	32
How cell biology can save the planet	32
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites	32
A comprehensive tRNA pseudouridine map uncovers targets dependent on human stand-alone pseudouridine synthases	32
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability	32
Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan	31
Grow up, beta cells	31
Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis	31
PTEN checkMAITs type-17 innate-like T cells	31
Host protection by two memory-like MAIT subsets	31
Cytoplasmic control of spindle architecture	31
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila	30
Stress response regulates cancer fibroblasts	30
Now is the greatest time to be in it	30
Biases in machine-learning models of human single-cell data	30
Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns	30
Author Correction: Defining E3 ligase–substrate relationships through multiplex CRISPR screening	30
Temporal and spatial topography of cell proliferation in cancer	30
Profiling cell death in COVID-19 pathology	30
Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition	29
Publisher Correction: o8G modifications rewire tumoral microRNAs	29
Reaffirming the value of model organisms in training scientific minds	29
A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts	29
Cholesterol sensing by the SCAP–FAM134B complex regulates ER-phagy and STING innate immunity	29
Haematopoietic ageing in health and lifespan	29
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation	29