Nature Cell Biology

Article	Citations
Pushing chromatin to totipotency	847
STING and fat crosstalk	575
Enhancing T cell therapy	447
Unravelling the endoplasmic reticulum–Golgi intermediate compartment in plant cells	260
Keeping membraneless organelles apart	255
tRNA flux and consistency in differentiation	245
COPIng with senescence	213
Restoring placental methylome	202
Atlas of amnion development during the first trimester of human pregnancy	201
Finding a chaperone for TDP-43	186
ER-associated RNA silencing promotes ER quality control	181
Designing protein-based artificial kinetochores as decoys to prevent meiotic errors in oocytes	172
The guinea pig serves as an alternative model to study human preimplantation development	170
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription	164
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication	163
Compression-dependent microtubule reinforcement enables cells to navigate confined environments	161
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage	158
RIPK1 and RIPK3 form mosaic necrosomes	155
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture	153
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells	153
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ	149
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources	149
Criteria for the standardization of stem-cell-based embryo models	147
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis	145
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function	144

Telomere dysfunction in ageing and age-related diseases	137
A guideline on the molecular ecosystem regulating ferroptosis	137
Regenerating the academic pipeline	136
How a ribosomal protein avoids mixed signals	136
Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1	135
A serendipitous discovery of a family of membrane remodelling proteins	130
Nuclear class 3 PI3K coactivates circadian clock	123
Implementing sustainable science in the lab	122
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise	121
Real-time and programmable transcriptome sequencing with PROFIT-seq	121
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates	119
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	118
A lysosomal surveillance response to stress extends healthspan	117
PRC2 shields the potency of human stem cells	114
TCF3, TCF12 and distinct enhancers regulate oocyte transcription	113
HSF1 renders NK cells too stressed to respond	113
Synthetic ZFTA fusions pinpoint disordered protein domain acquisition as a mechanism of brain tumorigenesis	112
Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth	107
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death	104
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription	103
Membranes regulate biomolecular condensates	101
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis	100
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	100
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer	98
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells	97
Spermidine is essential for fasting-mediated autophagy and longevity	95
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration	91
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation	91
Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer	91
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis	91
A cell biological perspective on Singapore’s scientific growth	90
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate	90
Telomeres are a life-extending gift	89
Waste management and cell death in T cells	88
It started with a western	87
Assessing gene loss after gene editing	85
A model for propagation of RNA structural memory through biomolecular condensates	85
Sequential enhancer state remodelling defines human germline competence and specification	85
Deep-learning for microscopy	83
Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells	83
Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs	82
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system	82
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome	80
Escape from X inactivation is directly modulated by Xist noncoding RNA	79
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth	77
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling	76
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition	75
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification	74
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells	72
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor	72

Time for lipid cell biology	71
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities	70
Tissue memory relies on stem cell priming in distal undamaged areas	70
The role of PINK1–Parkin in mitochondrial quality control	70
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes	69
The transcription factor GABPA is a master regulator of naive pluripotency	67
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity	67
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions	67
Zippering against the beat	67
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope	67
Autophagy-regulated mitochondrial inheritance controls early CD8+ T cell fate commitment	66
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity	66
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair	66
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming	66
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance	66
Cell-intrinsic and microenvironmental determinants of metastatic colonization	64
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	64
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis	64
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development	64
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool	64
Author Correction: Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants	62
Phase separation of EB1 guides microtubule plus-end dynamics	62
Keeping up with the Rag GTPases	62
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness	62
Author Correction: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation	61
Lysate-based pipeline to characterize microtubule-associated proteins uncovers unique microtubule behaviours	61
CoCo-ST detects global and local biological structures in spatial transcriptomics datasets	61
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma	60
Publisher Correction: m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	60
CAF heterogeneity and dynamics	60
Revealing the order of chromatin reorganization events with Dam&ChIC	59
Author Correction: Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	59
The molecular basis of human transcription-coupled DNA repair	58
Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells	58
Young secretory proteins go through a phase	58
Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis	58
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division	58
Mitochondrial YME1L1 governs unoccupied protein translocase channels	57
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing	55
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions	55
A foundation for tomorrow’s discoveries in cell biology	55
A milestone in epithelial–mesenchymal transition	55
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy	54
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung	54
The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux	54
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis	53
Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma	53
Multiplexed genome regulation in vivo with hyper-efficient Cas12a	53
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes	53
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation	53
Proximal proteomics reveals a landscape of human nuclear condensates	53
From phage genetics to chromosomes as mechanical objects	52
Autophagy-targeted NBR1–p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH	52
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression	52
Mapping T cell landscapes in B cell lymphomas	52
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis	52
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth	51
Long life depends on open communication	51
Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction	51
Cell origin of BRCA2-mutant breast cancer	51
Conference accessibility should be a universal concern	51
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT	50
VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells	50
Author Correction: Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development	50
ERCC6L2–CtIP condensation tunes end resection	50
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis	49
Modelling co-development between the somites and neural tube in human trunk-like structures	49
Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities	49
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression	49
Shaping the composition of the mitochondrial outer membrane	48
A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling	48
Spatial transcriptomic characterization of a Carnegie stage 7 human embryo	48
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells	47
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion	47
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels	47
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	46
Rear traction forces drive adherent tissue migration in vivo	46
Diet and longevity	46
Author Correction: Stiff matrix induces exosome secretion to promote tumour growth	45
Worrying through the ECM	45

Harnessing introns to monitor gene expression	45
Navigating human embryogenesis through tailored model selection	44
Author Correction: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	44
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling	44
Ribophagy relies on Rpl12	44
An expanding repertoire of E3 ligases in membrane Atg8ylation	44
Arginyl-tRNA synthetase in inflammation	44
Mapping paths through the nuclear pore complex	44
Metabolites in tumour interstitial fluid directly suppress T cells	43
Target cell cortical tension regulates macrophage trogocytosis	43
CD160 dictates anti-PD-1 immunotherapy resistance by regulating CD8+ T cell exhaustion in colorectal cancer	43
A bridge-like lipid transport protein controls plasma membrane lipid composition and fluidity	43
Cracking glioblastoma core regulatory codes	43
Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis	43
RNA sequestration in P-bodies sustains myeloid leukaemia	43
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier	43
In situ architecture of the human prohibitin complex	42
Nuclear mechanics as a determinant of nuclear pore complex plasticity	42
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition	42
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis	42
From fallout to renewal	42
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases	42
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	42
Stiff matrix induces exosome secretion to promote tumour growth	41
NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency	41
Evidence for widespread cytoplasmic structuring into mesoscale condensates	41
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis	41
The spectrin cytoskeleton integrates endothelial mechanoresponses	41
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation	41
Order and disorder in clathrin-mediated endocytosis	41
Intrinsically disordered CO2 sensors	40
FUS maintains TAZ fluidity and function	40
Pausing pluripotency via RNA methylation	40
Lipidomes define immune cell identity	40
METTL3 restrains autoimmunity in β-cells	40
Mitochondrial shape alteration by metabolites	40
Morula-derived trophectoderm stem cells	39
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation	39
A chosen STING with a PERKy trail	39
Forcing cell fate	39
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes	39
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers	38
Breaking up translation condensates in cancer	38
CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development	38
Remote control of AMPK via extracellular adenosine controls tissue growth	37
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection	37
Crossover patterning through condensation and coarsening of pro-crossover factors	37
Celebrating 25 years of cell biology	37
Lysosome lipid signalling from the periphery to neurons regulates longevity	36
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression	36
Nuclear pores safeguard the integrity of the nuclear envelope	36
Ex vivo imaging reveals the spatiotemporal control of ovulation	35
RNA-binding proteins pull in chromatin loops	35
Sugar unmasking for trafficking	35
A new cell in an old tactile sensory organ	35
Neutrophil-derived migrasomes are an essential part of the coagulation system	35
Sperm bud mitochondria to adjust the numbers	35
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos	35
Boosting cargo turnover with receptor mobility	35
RNA scaffolds the Golgi ribbon by forming condensates with GM130	35
A comprehensive tRNA pseudouridine map uncovers targets dependent on human stand-alone pseudouridine synthases	34
Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma	34
Sperm miRNAs exercise benefits	34
TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins	34
Softening redox homeostasis in cancer cells	34
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase	33
Gender equity: toward redefining values	33
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules	33
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing	33
Harnessing lysohormesis for healthy ageing	33
Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants	33
Combinatorial selective ER-phagy remodels the ER during neurogenesis	33
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation	33
Retinoic acid induces human gastruloids with posterior embryo-like structures	32
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability	32
NAD+ regulates nucleotide metabolism and genomic DNA replication	32
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites	32
Stress response regulates cancer fibroblasts	31
Author Correction: Defining E3 ligase–substrate relationships through multiplex CRISPR screening	31
Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan	31
How cell biology can save the planet	31
PTEN checkMAITs type-17 innate-like T cells	31
Profiling cell death in COVID-19 pathology	31
Grow up, beta cells	31
Host protection by two memory-like MAIT subsets	31
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation	31
Now is the greatest time to be in it	31
Cytoplasmic control of spindle architecture	31
Lessons from infrastructure and research advocacy in India	31
Publisher Correction: o8G modifications rewire tumoral microRNAs	30
Biases in machine-learning models of human single-cell data	30
Reaffirming the value of model organisms in training scientific minds	30
LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8	30
Cholesterol sensing by the SCAP–FAM134B complex regulates ER-phagy and STING innate immunity	30
Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis	30