Nature Cell Biology

Article	Citations
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis	506
Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis	302
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis	291
Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture	239
SIRT1 is downregulated by autophagy in senescence and ageing	231
Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker	221
Telomere dysfunction in ageing and age-related diseases	219
Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression	214
Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion	208
PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis	204
CRISPR technologies for precise epigenome editing	204
Nucleated transcriptional condensates amplify gene expression	187
Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling	187
Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy	183
Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets	181
Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity	161
Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma	155
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis	151
Targeted reprogramming of H3K27me3 resets epigenetic memory in plant paternal chromatin	149
ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration	128
Cellular and molecular architecture of the intestinal stem cell niche	127
Evaluating totipotency using criteria of increasing stringency	121
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury	120
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells	116
AP-1 imprints a reversible transcriptional programme of senescent cells	116

FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome	115
Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration	113
PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications	111
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control	111
Liquid-like protein interactions catalyse assembly of endocytic vesicles	109
Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity	109
Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis	106
Cell fate coordinates mechano-osmotic forces in intestinal crypt formation	100
A single-cell transcriptomic landscape of the lungs of patients with COVID-19	98
UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination	97
R-loops as Janus-faced modulators of DNA repair	96
Generic nature of the condensed states of proteins	96
Autophagosome biogenesis comes out of the black box	95
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age	95
The STING phase-separator suppresses innate immune signalling	95
In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states	95
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation	94
Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels	94
LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy	93
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA	91
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression	91
Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses	90
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis	89
Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress	88
Phase separation of SERRATE drives dicing body assembly and promotes miRNA processing in Arabidopsis	88
Depletion of aneuploid cells in human embryos and gastruloids	87
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis	87
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells	86
Extracellular serine controls epidermal stem cell fate and tumour initiation	83
The chromatin remodeler DDM1 prevents transposon mobility through deposition of histone variant H2A.W	80
Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance	80
Metabolic communication in the tumour–immune microenvironment	77
m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype	77
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance	77
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation	75
Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling	74
Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3	73
Cell type ontologies of the Human Cell Atlas	73
p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth	73
Membrane surfaces regulate assembly of ribonucleoprotein condensates	72
Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain	72
Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein	72
An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer	71
STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury	71
Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish	70
TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis	70
The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC	70
Exploring the expanding universe of small RNAs	69
Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses	69
Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation	69

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin	68
Mechanical force application to the nucleus regulates nucleocytoplasmic transport	68
Anatomical structures, cell types and biomarkers of the Human Reference Atlas	67
Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity	66
Reversible phase separation of HSF1 is required for an acute transcriptional response during heat shock	66
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung	66
Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis	66
METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis	65
Proteotoxic stress is a driver of the loser status and cell competition	64
Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19	63
Control of endothelial quiescence by FOXO-regulated metabolites	61
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia	61
Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development	61
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis	60
POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis	60
Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis	58
Human melanocyte development and melanoma dedifferentiation at single-cell resolution	57
A PRC2-independent function for EZH2 in regulating rRNA 2′-O methylation and IRES-dependent translation	57
A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression	56
NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices	56
Heat stress activates YAP/TAZ to induce the heat shock transcriptome	55
Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens	54
Spatial organization of transcribed eukaryotic genes	54
Functional mechanisms and abnormalities of the nuclear lamina	53
SMN-primed ribosomes modulate the translation of transcripts related to spinal muscular atrophy	53
An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory	53
Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility	53
The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels	52
The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin	51
Nucleotide imbalance decouples cell growth from cell proliferation	51
Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation	51
Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning	50
SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization	50
Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations	50
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	49
Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition	49
Metabolic determination of cell fate through selective inheritance of mitochondria	49
ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism	48
The histone reader PHF7 cooperates with the SWI/SNF complex at cardiac super enhancers to promote direct reprogramming	48
Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks	48
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes	48
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing	48
Eosinophil extracellular traps drive asthma progression through neuro-immune signals	47
Cell cycle-specific phase separation regulated by protein charge blockiness	46
STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy	46
Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome	46
Recycling of autophagosomal components from autolysosomes by the recycler complex	45
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability	45
Epithelial cell plasticity drives endoderm formation during gastrulation	45
Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates	45
BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2	45
Stiff matrix induces exosome secretion to promote tumour growth	45
Cohesin regulates homology search during recombinational DNA repair	44
Global profiling of RNA-binding protein target sites by LACE-seq	43
Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration	43
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling	43
Phosphatidylinositol 3-kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4	43
The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells	43
Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues	42
Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain	42
Deadly actin collapse by disulfidptosis	42
Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration	42
ATG9A protects the plasma membrane from programmed and incidental permeabilization	42
CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling	41
E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis	41
Multiplexed genome regulation in vivo with hyper-efficient Cas12a	41
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth	40
Illuminating RNA biology through imaging	40
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics	39
Untangling the web of intratumour heterogeneity	39
Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea	39
LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy	39
Dissecting OCT4 defines the role of nucleosome binding in pluripotency	39
ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation	38
A reversible shearing DNA probe for visualizing mechanically strong receptors in living cells	38
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity	38
Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases	38
Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechanosensitive structures	37
Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation	37
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	37

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates	37
Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth	36
Mammalian genome innovation through transposon domestication	36
Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death	36
Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements	36
A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers	35
Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma	35
Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis	34
Temporal and spatial topography of cell proliferation in cancer	34
A transitional stem cell state in the lung	34
BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling	34
Rear traction forces drive adherent tissue migration in vivo	34
Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis	34
Reciprocal regulation of chaperone-mediated autophagy and the circadian clock	34
Identification of two pathways mediating protein targeting from ER to lipid droplets	33
Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions	33
Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly	33
LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria	33
Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage	33
A guide to naming eukaryotic circular RNAs	33
Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids	32
Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis	32
Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction	32
CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells	32
The piRNA pathway is essential for generating functional oocytes in golden hamsters	32
Apoptosis in the fetal testis eliminates developmentally defective germ cell clones	32
A p53–phosphoinositide signalosome regulates nuclear AKT activation	32
Substoichiometric action of long noncoding RNAs	32
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair	32
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition	31
Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis	31
Phase separation of EB1 guides microtubule plus-end dynamics	31
Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration	31
A biomechanical switch regulates the transition towards homeostasis in oesophageal epithelium	31
Stem cell-derived synthetic embryos self-assemble by exploiting cadherin codes and cortical tension	31
Dynamin-dependent vesicle twist at the final stage of clathrin-mediated endocytosis	31
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination	30
A single-cell transcriptome atlas profiles early organogenesis in human embryos	30
Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence	30
Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters	30
Monocytes deposit migrasomes to promote embryonic angiogenesis	30
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage	30
Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs	30
Opportunities and challenges in studying the extracellular vesicle corona	30
Assembly of a persistent apical actin network by the formin Frl/Fmnl tunes epithelial cell deformability	30
ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection	29
Sequential enhancer state remodelling defines human germline competence and specification	29
YAP/TAZ drives cell proliferation and tumour growth via a polyamine–eIF5A hypusination–LSD1 axis	29
Lysosome lipid signalling from the periphery to neurons regulates longevity	29
Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells	29
The spectrin cytoskeleton integrates endothelial mechanoresponses	29
Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells	28
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	28
Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation	28
Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis	28
Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration	28
53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis	28
dCas9-based gene editing for cleavage-free genomic knock-in of long sequences	27
Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space	27
The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis	27
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation	27
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function	27
Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer	27
Stalled replication fork protection limits cGAS–STING and P-body-dependent innate immune signalling	27
METALIC reveals interorganelle lipid flux in live cells by enzymatic mass tagging	27
Publisher Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation	26
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature	26
Optogenetic manipulation of cellular communication using engineered myosin motors	26
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics	26
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)	26
SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence	26
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness	26
Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection	25
A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	25
Monocyte and dendritic cell defects in COVID-19	25
Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis	25
Synthetic immunomodulation with a CRISPR super-repressor in vivo	25
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer	25
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells	25
Lysate-based pipeline to characterize microtubule-associated proteins uncovers unique microtubule behaviours	25
LKB1 inactivation modulates chromatin accessibility to drive metastatic progression	25
Super-resolved 3D tracking of cargo transport through nuclear pore complexes	25
CDK1–cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry	24
Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay	24
Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma	24
Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors	24
The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1	23
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity	23
Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic cell development	23
Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors	23
Proton-gated anion transport governs macropinosome shrinkage	23
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities	23
FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance	22
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth	22
Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages	22