Nature Cell Biology

Article	Citations
STING and fat crosstalk	719
TRIM8 in Ewing sarcoma	481
Force boosts SARS-CoV-2 invasion	390
Enhancing T cell therapy	289
Pushing chromatin to totipotency	228
Restoring placental methylome	212
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells	195
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription	181
Unravelling the endoplasmic reticulum–Golgi intermediate compartment in plant cells	180
Keeping membraneless organelles apart	164
tRNA flux and consistency in differentiation	160
COPIng with senescence	150
Finding a chaperone for TDP-43	148
RIPK1 and RIPK3 form mosaic necrosomes	144
Compression-dependent microtubule reinforcement enables cells to navigate confined environments	142
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication	140
Criteria for the standardization of stem-cell-based embryo models	137
ER-associated RNA silencing promotes ER quality control	133
Atlas of amnion development during the first trimester of human pregnancy	129
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage	127
An inflammatory switch for stem cell plasticity	126
The guinea pig serves as an alternative model to study human preimplantation development	123
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources	123
Telomere dysfunction in ageing and age-related diseases	122
A guideline on the molecular ecosystem regulating ferroptosis	120

Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis	120
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture	119
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function	116
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ	115
A serendipitous discovery of a family of membrane remodelling proteins	115
Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1	112
Regenerating the academic pipeline	111
How a ribosomal protein avoids mixed signals	110
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation	107
PRC2 shields the potency of human stem cells	105
HSF1 renders NK cells too stressed to respond	105
TCF3, TCF12 and distinct enhancers regulate oocyte transcription	104
Membranes regulate biomolecular condensates	104
Nuclear class 3 PI3K coactivates circadian clock	104
Implementing sustainable science in the lab	100
Real-time and programmable transcriptome sequencing with PROFIT-seq	99
A lysosomal surveillance response to stress extends healthspan	98
Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements	98
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis	94
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise	94
The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate	94
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis	91
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	90
Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer	89
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription	88
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells	88
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates	88
Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth	87
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	87
Spermidine is essential for fasting-mediated autophagy and longevity	86
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer	85
A cell biological perspective on Singapore’s scientific growth	83
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration	83
Deep-learning for microscopy	82
Xist seeds X inactivation	82
Telomeres are a life-extending gift	79
It started with a western	78
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification	77
Waste management and cell death in T cells	77
Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells	75
Sequential enhancer state remodelling defines human germline competence and specification	74
Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs	73
Time for lipid cell biology	72
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor	72
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities	72
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth	70
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome	68
Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning	67
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition	67
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system	66

p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells	63
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling	63
Tissue memory relies on stem cell priming in distal undamaged areas	62
The role of PINK1–Parkin in mitochondrial quality control	62
Single-cell spatial transcriptomics	61
The transcription factor GABPA is a master regulator of naive pluripotency	61
Surveying the dividing genome	61
ASTE1 cutting to block DNA end resection	60
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming	60
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity	59
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions	59
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope	59
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development	58
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes	58
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair	58
Phase separation of EB1 guides microtubule plus-end dynamics	57
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair	57
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness	57
Cell-intrinsic and microenvironmental determinants of metastatic colonization	56
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	56
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity	56
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance	55
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy	55
A single-cell transcriptomic landscape of the lungs of patients with COVID-19	55
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis	55
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool	55
Author Correction: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation	54
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation	54
Golden opportunity for piRNA in female fertility	54
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes	54
Keeping up with the Rag GTPases	54
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung	54
Revealing the order of chromatin reorganization events with Dam&ChIC	53
Author Correction: Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	53
Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis	53
Author Correction: Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants	53
A milestone in epithelial–mesenchymal transition	52
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis	52
Autophagy-targeted NBR1–p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH	52
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing	52
CAF heterogeneity and dynamics	52
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma	51
Cell type ontologies of the Human Cell Atlas	51
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division	51
Publisher Correction: m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	51
Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells	50
Lysate-based pipeline to characterize microtubule-associated proteins uncovers unique microtubule behaviours	50
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions	50
The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels	50
Mitochondrial YME1L1 governs unoccupied protein translocase channels	50
Multiplexed genome regulation in vivo with hyper-efficient Cas12a	50
From phage genetics to chromosomes as mechanical objects	49
COVID-19 lung atlas	49
Species-specific cortex features	49
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression	49
A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling	49
Dissecting melanocytes to predict melanoma	48
Publisher Correction: POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis	48
Mapping T cell landscapes in B cell lymphomas	48
Cell origin of BRCA2-mutant breast cancer	48
Long life depends on open communication	47
Conference accessibility should be a universal concern	46
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis	46
Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma	46
Shaping the composition of the mitochondrial outer membrane	46
Rear traction forces drive adherent tissue migration in vivo	45
Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells	45
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression	44
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination	44
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	44
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion	44
VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells	44
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels	44
Spatial transcriptomic characterization of a Carnegie stage 7 human embryo	44
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT	43
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth	43
Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities	43
Worrying through the ECM	42
Diet and longevity	42
Mapping paths through the nuclear pore complex	42

Harnessing introns to monitor gene expression	42
Ribophagy relies on Rpl12	41
Author Correction: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	41
Navigating human embryogenesis through tailored model selection	41
Author Correction: Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly	40
Author Correction: Stiff matrix induces exosome secretion to promote tumour growth	40
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	40
Metabolites in tumour interstitial fluid directly suppress T cells	40
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation	39
RNA sequestration in P-bodies sustains myeloid leukaemia	39
NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency	39
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis	39
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis	38
A bridge-like lipid transport protein controls plasma membrane lipid composition and fluidity	38
Evidence for widespread cytoplasmic structuring into mesoscale condensates	38
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition	38
Arginyl-tRNA synthetase in inflammation	38
An expanding repertoire of E3 ligases in membrane Atg8ylation	38
In situ architecture of the human prohibitin complex	38
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling	37
The spectrin cytoskeleton integrates endothelial mechanoresponses	37
METTL3 restrains autoimmunity in β-cells	37
A chosen STING with a PERKy trail	37
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases	37
Order and disorder in clathrin-mediated endocytosis	37
FUS maintains TAZ fluidity and function	37
Mitochondrial shape alteration by metabolites	37
Stiff matrix induces exosome secretion to promote tumour growth	37
Modelling SARS-CoV-2 CNS infection	37
Pausing pluripotency via RNA methylation	37
Breaking up translation condensates in cancer	36
CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development	36
Ex vivo imaging reveals the spatiotemporal control of ovulation	36
Nuclear pores safeguard the integrity of the nuclear envelope	36
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers	36
Lipidomes define immune cell identity	36
Celebrating 25 years of cell biology	36
Intrinsically disordered CO2 sensors	36
Crossover patterning through condensation and coarsening of pro-crossover factors	36
Neutrophil-derived migrasomes are an essential part of the coagulation system	35
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos	35
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation	35
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity	35
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression	35
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes	35
Lysosome lipid signalling from the periphery to neurons regulates longevity	34
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection	34
Human neural tube morphogenesis in a dish	34
Boosting cargo turnover with receptor mobility	33
Sugar unmasking for trafficking	33
Gender equity: toward redefining values	33
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules	33
A new cell in an old tactile sensory organ	33
Sperm bud mitochondria to adjust the numbers	33
Softening redox homeostasis in cancer cells	32
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability	32
Harnessing lysohormesis for healthy ageing	32
Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants	31
Combinatorial selective ER-phagy remodels the ER during neurogenesis	31
RNA scaffolds the Golgi ribbon by forming condensates with GM130	31
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase	31
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites	30
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing	30
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation	30
FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance	30
How cell biology can save the planet	30
NAD+ regulates nucleotide metabolism and genomic DNA replication	30
Retinoic acid induces human gastruloids with posterior embryo-like structures	30
Lessons from infrastructure and research advocacy in India	29
Author Correction: Defining E3 ligase–substrate relationships through multiplex CRISPR screening	29
Cytoplasmic control of spindle architecture	29
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics	29
Biases in machine-learning models of human single-cell data	29
Stress response regulates cancer fibroblasts	29
Grow up, beta cells	29
Disulfidptosis meets antitumour immunity	29
Now is the greatest time to be in it	29
PTEN checkMAITs type-17 innate-like T cells	29
Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis	29
Cohesin regulates homology search during recombinational DNA repair	28
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila	28
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis	28
ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels	28
Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome	28
Profiling cell death in COVID-19 pathology	28
Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan	28
Temporal and spatial topography of cell proliferation in cancer	28
Architecture and dynamics of a desmosome–endoplasmic reticulum complex	28
Host protection by two memory-like MAIT subsets	27
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation	27
CLICing on endocytic cargoes for cancer invasion	27
Publisher Correction: o8G modifications rewire tumoral microRNAs	27
Stem cell progeny liaisons in regeneration	27
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes	26
Mentoring the next generation of cell biologists	26