Nature Cell Biology

Article	Citations
STING and fat crosstalk	662
TRIM8 in Ewing sarcoma	447
Force boosts SARS-CoV-2 invasion	359
Enhancing T cell therapy	343
Pushing chromatin to totipotency	275
Restoring placental methylome	220
Unravelling the endoplasmic reticulum–Golgi intermediate compartment in plant cells	219
Keeping membraneless organelles apart	188
tRNA flux and consistency in differentiation	187
Immune memory in individuals with COVID-19	169
An inflammatory switch for stem cell plasticity	167
COPIng with senescence	162
Finding a chaperone for TDP-43	155
RIPK1 and RIPK3 form mosaic necrosomes	153
ETV2 functions as a pioneer factor to regulate and reprogram the endothelial lineage	139
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis	138
Criteria for the standardization of stem-cell-based embryo models	134
The guinea pig serves as an alternative model to study human preimplantation development	130
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells	129
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription	129
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources	124
Compression-dependent microtubule reinforcement enables cells to navigate confined environments	124
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture	122
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ	116
ER-associated RNA silencing promotes ER quality control	115

Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function	115
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication	114
Telomere dysfunction in ageing and age-related diseases	110
A guideline on the molecular ecosystem regulating ferroptosis	109
Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1	108
Implementing sustainable science in the lab	108
A serendipitous discovery of a family of membrane remodelling proteins	108
Regenerating the academic pipeline	107
Diverse heterochromatin-associated proteins repress distinct classes of genes and repetitive elements	103
How a ribosomal protein avoids mixed signals	103
Publisher Correction: p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth	102
TCF3, TCF12 and distinct enhancers regulate oocyte transcription	100
STAM and Hrs interact sequentially with IFN-α Receptor to control spatiotemporal JAK–STAT endosomal activation	99
PRC2 shields the potency of human stem cells	97
Real-time and programmable transcriptome sequencing with PROFIT-seq	96
HSF1 renders NK cells too stressed to respond	96
Nuclear class 3 PI3K coactivates circadian clock	95
Membranes regulate biomolecular condensates	94
Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer	94
Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth	93
The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription	93
The mechanics of crypt morphogenesis	90
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration	89
Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise	89
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer	87
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis	86
Spermidine is essential for fasting-mediated autophagy and longevity	85
Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	84
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis	82
A cell biological perspective on Singapore’s scientific growth	81
Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells	81
Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis	81
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates	81
Deep-learning for microscopy	80
Xist seeds X inactivation	80
Mapping the foetal striatum	79
Telomeres are a life-extending gift	78
It started with a western	77
Waste management and cell death in T cells	76
Intron-encoded cistronic transcripts for minimally invasive monitoring of coding and non-coding RNAs	76
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling	76
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification	76
Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning	74
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor	73
Tissue memory relies on stem cell priming in distal undamaged areas	73
Time for lipid cell biology	71
N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition	70
Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities	69
Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells	68
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells	68

Sequential enhancer state remodelling defines human germline competence and specification	68
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth	68
The role of PINK1–Parkin in mitochondrial quality control	67
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome	66
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system	65
Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker	65
Surveying the dividing genome	64
Single-cell spatial transcriptomics	64
The transcription factor GABPA is a master regulator of naive pluripotency	63
ASTE1 cutting to block DNA end resection	62
Publisher Correction: Epithelial cell plasticity drives endoderm formation during gastrulation	62
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity	61
Cell-intrinsic and microenvironmental determinants of metastatic colonization	60
Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions	60
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes	59
CTCF–CTCF loops and intra-TAD interactions show differential dependence on cohesin ring integrity	59
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming	59
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool	59
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope	58
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair	58
XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair	58
Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development	57
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance	57
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness	57
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing	55
CAF heterogeneity and dynamics	54
Phase separation of EB1 guides microtubule plus-end dynamics	54
Keeping up with the Rag GTPases	53
Author Correction: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation	53
Golden opportunity for piRNA in female fertility	53
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis	52
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing	52
Retraction Note: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma	52
Author Correction: Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification	52
Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis	52
Author Correction: Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants	52
Lysate-based pipeline to characterize microtubule-associated proteins uncovers unique microtubule behaviours	52
Publisher Correction: m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	51
Cell type ontologies of the Human Cell Atlas	51
A single-cell transcriptomic landscape of the lungs of patients with COVID-19	51
Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy	51
The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels	51
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis	50
A milestone in epithelial–mesenchymal transition	49
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung	49
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation	49
Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division	49
Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells	49
Mitochondrial YME1L1 governs unoccupied protein translocase channels	49
Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions	48
Non-invasive and high-throughput interrogation of exon-specific isoform expression	48
A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling	48
CD63 sorts cholesterol into endosomes for storage and distribution via exosomes	48
From phage genetics to chromosomes as mechanical objects	48
Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression	48
Multiplexed genome regulation in vivo with hyper-efficient Cas12a	48
Species-specific cortex features	48
COVID-19 lung atlas	48
Mapping T cell landscapes in B cell lymphomas	47
Publisher Correction: POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis	46
Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth	46
Dissecting melanocytes to predict melanoma	46
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion	45
VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells	45
Cell origin of BRCA2-mutant breast cancer	45
Rear traction forces drive adherent tissue migration in vivo	45
Long life depends on open communication	45
Conference accessibility should be a universal concern	45
Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma	44
Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities	43
Spatial transcriptomic characterization of a Carnegie stage 7 human embryo	43
Spermidine mediates acetylhypusination of RIPK1 to suppress diabetes onset and progression	43
Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels	43
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT	43
Diet and longevity	42
Mapping paths through the nuclear pore complex	42
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination	42
Harnessing introns to monitor gene expression	42
Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition	42
Ribophagy relies on Rpl12	41

Navigating human embryogenesis through tailored model selection	41
The glutathione S-transferase Gstt1 drives survival and dissemination in metastases	41
Worrying through the ECM	41
Author Correction: A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids	41
Metabolites in tumour interstitial fluid directly suppress T cells	40
Author Correction: Stiff matrix induces exosome secretion to promote tumour growth	40
Author Correction: Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly	40
Arginyl-tRNA synthetase in inflammation	40
Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis	40
In situ architecture of the human prohibitin complex	39
An expanding repertoire of E3 ligases in membrane Atg8ylation	39
RNA sequestration in P-bodies sustains myeloid leukaemia	39
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation	38
Stiff matrix induces exosome secretion to promote tumour growth	38
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition	38
Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling	38
FUS maintains TAZ fluidity and function	37
Evidence for widespread cytoplasmic structuring into mesoscale condensates	37
Modelling SARS-CoV-2 CNS infection	37
Order and disorder in clathrin-mediated endocytosis	37
NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency	37
m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency	37
METTL3 restrains autoimmunity in β-cells	37
The spectrin cytoskeleton integrates endothelial mechanoresponses	37
OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis	37
Intrinsically disordered CO2 sensors	36
Pausing pluripotency via RNA methylation	36
Mitochondrial shape alteration by metabolites	36
A chosen STING with a PERKy trail	36
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity	35
CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development	35
H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos	35
Celebrating 25 years of cell biology	35
Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers	35
Breaking up translation condensates in cancer	35
Ex vivo imaging reveals the spatiotemporal control of ovulation	34
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability	34
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression	34
Neutrophil-derived migrasomes are an essential part of the coagulation system	34
Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection	34
Lysosome lipid signalling from the periphery to neurons regulates longevity	34
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation	34
Softening redox homeostasis in cancer cells	33
Human neural tube morphogenesis in a dish	33
A new cell in an old tactile sensory organ	33
Nuclear pores safeguard the integrity of the nuclear envelope	33
Sperm bud mitochondria to adjust the numbers	33
Lipidomes define immune cell identity	33
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes	33
Boosting cargo turnover with receptor mobility	33
Polycomb repressive complex 2 shields naïve human pluripotent cells from trophectoderm differentiation	32
Sugar unmasking for trafficking	32
FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance	32
Gender equity: toward redefining values	32
A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules	32
NAD+ regulates nucleotide metabolism and genomic DNA replication	31
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability	31
Generic nature of the condensed states of proteins	31
Retinoic acid induces human gastruloids with posterior embryo-like structures	31
RNA scaffolds the Golgi ribbon by forming condensates with GM130	31
Combinatorial selective ER-phagy remodels the ER during neurogenesis	31
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase	31
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing	31
Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan	30
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites	30
Harnessing lysohormesis for healthy ageing	30
Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants	30
Lessons from infrastructure and research advocacy in India	29
How cell biology can save the planet	29
Biases in machine-learning models of human single-cell data	29
Author Correction: Defining E3 ligase–substrate relationships through multiplex CRISPR screening	28
A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts	28
Profiling cell death in COVID-19 pathology	28
Now is the greatest time to be in it	28
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila	28
PTEN checkMAITs type-17 innate-like T cells	28
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics	28
LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8	28
Stress response regulates cancer fibroblasts	28
ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels	28
Host protection by two memory-like MAIT subsets	27
Publisher Correction: o8G modifications rewire tumoral microRNAs	27
Stem cell progeny liaisons in regeneration	27
CLICing on endocytic cargoes for cancer invasion	27
NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling	27
Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition	26
Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome	26
Architecture and dynamics of a desmosome–endoplasmic reticulum complex	26
RETRACTED ARTICLE: CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling	26
Mentoring the next generation of cell biologists	25
Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis	25
Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns	25
Real-time mirroring of therapy	25
How mothers program sons to use their Y chromosomes	25
Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation	25