EMBO Reports

Article	Citations
CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection	172
lncRNA‐encoded pep‐AP attenuates the pentose phosphate pathway and sensitizes colorectal cancer cells to Oxaliplatin	131
The mission to ensure continued funding for excellent basic research	130
Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation	114
Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair	105
Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus	105
Lamin A‐mediated nuclear lamina integrity is required for proper ciliogenesis	102
Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice	99
Aire‐dependent transcripts escape Raver2‐induced splice‐event inclusion in the thymic epithelium	91
LGBTIQ+N	89
Enhancing Spns2/S1P in macrophages alleviates hyperinflammation and prevents immunosuppression in sepsis	89
The Golgi microtubules regulate single cell durotaxis	86
Through an ecological lens	84
Concerns about academic freedom caused by the Russia–Ukraine War	81
TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment	80
E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2	76
XIAP promotes melanoma growth by inducing tumour neutrophil infiltration	71
The post‐translational regulation of transcription factor EB (TFEB) in health and disease	65
SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3	61
SCF FBXW7 regulates G2‐M progression through control of CCNL1	60
Dynamin‐like proteins mediate extracellular vesicle secretion in Mycobacterium tuberculosis	59
METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m6A homeostasis	58
Functional skewing of TRIM21‐SIRT5 interplay dictates IL‐1β production in DSS‐induced colitis	58
Global and precise identification of functional miRNA targets in mESCs by integrative analysis	57
UBAP2L‐dependent coupling of PLK1 localization and stability during mitosis	57

The transcriptional regulator Sin3A balances IL‐17A and Foxp3 expression in primary CD4 T cells	55
SPTing across condensates: SEC‐mediated translocation of SPT complex from pausing condensates to elongation condensates	54
pH regulates hematopoietic stem cell potential via polyamines	54
Noncanonical Wnt signaling promotes colon tumor growth, chemoresistance and tumor fibroblast activation	50
Zika virus alters centrosome organization to suppress the innate immune response	49
A Good Day for Helminths: how parasite‐derived GDH suppresses inflammatory responses	49
Scalable RT‐LAMP‐based SARS‐CoV‐2 testing for infection surveillance with applications in pandemic preparedness	49
PRMT5 links lipid metabolism to contractile function of skeletal muscles	49
Morphofunctional changes at the active zone during synaptic vesicle exocytosis	48
Tissue‐like environments shape functional interactions of HIV‐1 with immature dendritic cells	47
Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis	47
Functions of animal microRNA‐encoded peptides: the race is on!	46
Resting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF‐1α	45
Sequestration of LINE‐1 in cytosolic aggregates by MOV10 restricts retrotransposition	45
Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network	44
Sci‐Con	44
Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice	44
Animals do count	44
Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo	44
Striking the right balance between youth and experience	44
A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength	44
The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive‐strand R	43
Energetic landscape of polycystin channel gating	43
Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster	42
IL‐21 has a critical role in establishing germinal centers by amplifying early B cell proliferation	42
Single‐cell analysis reveals dynamic changes of neural cells in developing human spinal cord	41
Biparatopic sybodies neutralize SARS‐CoV‐2 variants of concern and mitigate drug resistance	40
Specific N‐glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning	40
Viral diseases and the brain	39
Bipolar‐associated miR‐499‐5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2	39
The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity	38
The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis	37
GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1‐dependent manner	37
Evolutionary remodelling of N‐terminal domain loops fine‐tunes SARS‐CoV‐2 spike	37
DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres	37
STAT5bis a key effector ofNRG‐1/ERBB4‐mediated myocardial growth	37
Single cell clonal analysis identifies an AID ‐dependent pathway of plasma cell differentiation	36
A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation	36
BTNL2 promotes colitis‐associated tumorigenesis in mice by regulating IL‐22 production	36
Vitamin D receptor enhances NLRC4 inflammasome activation by promoting NAIPs–NLRC4 association	36
Introducing quality measures in an academic research consortium	36
DJ‐1 depletion prevents immunoaging in T‐cell compartments	36
#IchbinHannah and the fight for permanent jobs for postdocs	36
FOXM1 network in association with TREM1 suppression regulates NET formation in diabetic foot ulcers	35
A human coronavirus OC43‐derived polypeptide causes neuropathic pain	35
Autophagy orchestrates the crosstalk between cells and organs	35
The regulation of human blastoid research	35
Bclaf1 regulates c‐FLIP expression and protects cells from TNF‐induced apoptosis and tissue injury	35
ER ‐phagy: selective autophagy of the endoplasmic reticulum	35
Tick‐borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2	34

Malaria parasites release vesicle subpopulations with signatures of different destinations	34
mPFC DUSP1 mediates adolescent cocaine exposure‐induced higher sensitivity to drug in adulthood	33
Understanding redundancy and resilience	33
Getting the message right	33
Ovol1/2 loss‐induced epidermal defects elicit skin immune activation and alter global metabolism	33
Constructive correction	32
Fish faeces and ocean life	32
CDK9 and PP2A regulate RNA polymerase II transcription termination and coupled RNA maturation	32
Pericyte stem cells induce Ly6G+ cell accumulation and immunotherapy resistance in pancreatic cancer	32
Gold mining nature for natural products	32
Isotope‐labeled amyloid‐β does not transmit to the brain in a prion‐like manner after peripheral administration	31
Tonic TNF conditioning of macrophages safeguards stimulus‐specific inflammatory responses	31
CACGAACTACCCTAA	31
Inductive prediction in biology	30
TMBIM5 is the Ca 2+ /H + antiporter of mammalian mitochondria	30
Open reading frame dominance indicates protein‐coding potential of RNAs	30
Powering on cGAMP mini factories	30
A need for recalibrating access and benefit sharing	29
Phase‐separated foci of EML4‐ALK facilitate signalling and depend upon an active kinase conformation	29
Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation	29
The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins	29
On predictions and laws in biological evolution	28
A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection	28
The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging	28
Learning tricks from old dogs	28
Evolution of pathogen virulence	28
The human GID complex engages two independent modules for substrate recruitment	28
Confusion	28
NuRD‐independent Mi‐2 activity represses ectopic gene expression during neuronal maturation	28
Reducing oxidative protein folding alleviates senescence by minimizing ER‐to‐nucleus H2O2 release	27
The Autophagy Receptor TAX1BP1 ( T6BP ) improves antigen presentation by MHC‐II molecules	27
The need for sustainable leadership in academia	27
Intra‐epithelial non‐canonical Activin A signaling safeguards prostate progenitor quiescence	27
Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria	26
Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress	26
Bench science	26
Phosphorylation by casein kinase 2 enhances the interaction between ER‐phagy receptor TEX264 and ATG8 proteins	26
KIAA1429/VIRMA promotes breast cancer progression by m6A‐dependent cytosolic HAS2 stabilization	26
GM‐CSF suppresses antioxidant signaling and drives IL‐1β secretion through NRF2 downregulation	26
PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability	26
A plea for the ultimate optimism	26
ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness	26
Circadian oscillation in primary cilium length by clock genes regulates fibroblast cell migration	25
Optogenetic control of YAP cellular localisation and function	25
Rabaptin5 targets autophagy to damaged endosomes and Salmonella vacuoles via FIP200 and ATG16L1	25
An ULK1/2‐PXN mechanotransduction pathway suppresses breast cancer cell migration	25
F‐domain valency determines outcome of signaling through the angiopoietin pathway	25
Scholars in peril: when being a scientist can land you in jail (or worse)	25
Confessions of a microscope hoarder	25
CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B	24
Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding	24
Dual control of dopamine in Drosophila myeloid‐like progenitor cell proliferation and regulation of lymph gland growth	24
TPLATE complex‐dependent endocytosis attenuates CLAVATA1 signaling for shoot apical meristem maintenance	24
Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice	24
Diacylglycerols interact with the L2 lipidation site in TRPC3 to induce a sensitized channel state	24
Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway	24
Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6‐dependent pathway	24
RNA polymerase II CTD is dispensable for transcription and required for termination in human cells	24
Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation	23
Rab21 regulates caveolin‐1‐mediated endocytic trafficking to promote immature neurite pruning	23
m6A methylation promotes white‐to‐beige fat transition by facilitating Hif1a translation	23
Autism therapy at crossroads	23
The splicing‐regulatory lncRNA NTRAS sustains vascular integrity	23
DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation	23
Cx43‐mediated sorting of miRNAs into extracellular vesicles	23
MAP kinase cascades in plant development and immune signaling	23
FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1	23
Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis	23
Hedgehog signaling can enhance glycolytic ATP production in the Drosophila wing disc	23
Mitochondrial F 1 F O ATP synthase determines the local proton motive force at cristae rims	23
LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1	23
The mind of a scientist	22
We can do better	22
LincRNA‐EPS impairs host antiviral immunity by antagonizing viral RNA–PKR interaction	22
Descending dopaminergic pathway facilitates itch signal processing via activating spinal GRPR+ neurons	22
Waste management	22
Oxygen‐regulated post‐translation modifications as master signalling pathway in cells	21
Endothelial‐immune crosstalk contributes to vasculopathy in nonalcoholic fatty liver disease	21
USP17 is required for peripheral trafficking of lysosomes	21
Two redundant ubiquitin‐dependent pathways of BRCA1 localization to DNA damage sites	21

Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation	21
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1	20
Keep biology weird	20
NPM1 ablation induces HSC aging and inflammation to develop myelodysplastic syndrome exacerbated by p53 loss	20
Engineering a customizable antibacterial T6SS‐based platform in Vibrio natriegens	20
Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members	20
Structural study of UFL1‐UFC1 interaction uncovers the role of UFL1 N‐terminal helix in ufmylation	20
Exosome‐like nanoparticles from Mulberry bark prevent DSS‐induced colitis via the AhR/COPS8 pathway	20
Ethical aspects of GMO regulation in the EU	20
Combining organotypic tissue culture with light‐sheet microscopy (OTCxLSFM) to study glioma invasion	20
MOV10 recruits DCP2 to decap human LINE‐1 RNA by forming large cytoplasmic granules with phase separation properties	20
Differential roles of the fish chitinous membrane in gut barrier immunity and digestive compartments	20
An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase	20
Estrogen receptor alpha signaling in dendritic cells modulates autoimmune disease phenotype in mice	20
The Drosophila mitotic spindle orientation machinery requires activation, not just localization	20
The chromatin factorROWcooperates withBEAF‐32 in regulating long‐range inducible genes	19
Lipid and protein content profiling of isolated native autophagic vesicles	19
A trashed treasure	19
The human FOXM1 homolog promotes basal progenitor cell proliferation and cortical folding in mouse	19
Bioenergetics of early life	19
Once in a lifetime	19
The perceived decline of “disruptive” science and technology	19
Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV	19
Adult neural stem cells and neurogenesis are resilient to intermittent fasting	19
Lipin‐2 regulates the antiviral and anti‐inflammatory responses to interferon	19
The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties	19
Piwi/piRNAs control food intake by promoting neuropeptide F expression in locusts	19
Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole	19
The obesity‐linked human lncRNA AATBC stimulates mitochondrial function in adipocytes	19
Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing	19
Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL‐1R/TLR signals	19
Cancer‐cell‐secreted extracellular vesicles target p53 to impair mitochondrial function in muscle	19
The cancer microbiome	18
Intracellular growth of Brucella is mediated by Dps‐dependent activation of ferritinophagy	18
Osteoclasts adapt to physioxia perturbation through DNA demethylation	18
Plasmodium sporozoite disintegration during skin passage limits malaria parasite transmission	18
Myddosome clustering in IL‐1 receptor signaling regulates the formation of an NF‐kB activating signalosome	18
hnRNP R negatively regulates transcription by modulating the association of P‐TEFb with 7SK and BRD4	18
EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole	18
Candida albicans induces neutrophil extracellular traps and leucotoxic hypercitrullination via candidalysin	18
SARS‐CoV‐2‐related bat virus behavior in human‐relevant models sheds light on the origin of COVID‐19	18
Bassoon controls synaptic vesicle release via regulation of presynaptic phosphorylation and cAMP	18
ALS ‐linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain‐of‐function	18
Co‐evolution within the plant holobiont drives host performance	18
Metabolomics meets systems immunology	18
The taste of vitamin C inDrosophila	17
Cold cases and ancient trade routes	17
Pseudomonas syringae senses polyphenols via phosphorelay crosstalk to inhibit virulence	17
Metabolic routing maintains the unique fatty acid composition of phosphoinositides	17
Scratching the ocean surface	17
FTO negatively regulates the cytotoxic activity of natural killer cells	17
Trained immunity induced by high‐salt diet impedes stroke recovery	17
Lamarck redux and other false arguments against SARS‐CoV‐2 vaccination	17
Structural basis for specific inhibition of the highly sensitive ShHTL7 receptor	17
Losing bigly	17
A short history of beer brewing	17
Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody	17
Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells	17
Retrotransposon insertions associated with risk of neurologic and psychiatric diseases	17
RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells	17
Cryo‐EM structure of the octameric pore of Clostridium perfringens β‐toxin	16
Frizzled receptors facilitate Tiki inhibition of Wnt signaling at the cell surface	16
Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming	16
Time for change in research careers	16
The fate of surplus laboratory animals	16
Dengue virus NS1 protein conveys pro‐inflammatory signals by docking onto high‐density lipoproteins	16
Centrosome linker protein C‐Nap1 maintains stem cells in mouse testes	16
The international of wisdom	16
Constricted migration is associated with stable 3D genome structure differences in cancer cells	16
Impaired activation of transposable elements in SARS‐CoV‐2 infection	16
Vaccines beyond antibodies	15
The Physalis Improvement Project: blending research with community science	15
Degradation of WTAP blocks antiviral responses by reducing the m 6 A levels of IRF3 and IFNAR1 mRNA	15
Lysosomal K+ channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease	15
Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors	15
Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia	15
Extracellular vesicles from malaria‐infected red blood cells: not all are secreted equal	15
HOIP limits anti‐tumor immunity by protecting against combined TNF and IFN‐gamma‐induced apoptosis	15
Metabolic plasticity sustains the robustness of Caenorhabditis elegans embryogenesis	15
Threatened forests	15
The structure of fly Teneurin‐m reveals an asymmetric self‐assembly that allows expansion into zippers	15
Immune–epithelial cell cross‐talk enhances antiviral responsiveness to SARS‐CoV‐2 in children	15
Muscle‐specific Cand2 is translationally upregulated by mTORC1 and promotes adverse cardiac remodeling	15
Reconsidering editorial consideration	14
A dual‐function SNF2 protein drives chromatid resolution and nascent transcript removal in mitosis	14
CIP2A deficiency promotes depression‐like behaviors in mice through inhibition of dendritic arborization	14
PLK1‐dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV‐infected mice	14
Cohesin contributes to transcriptional repression of stage‐specific genes in the human malaria parasite	14
The P4‐ATPase Drs2 interacts with and stabilizes the multisubunit tethering complex TRAPPIII in yeast	14
ABCB‐mediated shootward auxin transport feeds into the root clock	14
Legionella‐ and host‐driven lipid flux at LCV‐ER membrane contact sites promotes vacuole remodeling	14
CTCF shapes chromatin structure and gene expression in health and disease	14
A20 controls RANK ‐dependent osteoclast formation and bone physiology	14
A quantitative fluorescence‐based approach to study mitochondrial protein import	14
High salt activates p97 to reduce host antiviral immunity by restricting Viperin induction	14