OOIR: Observatory of International Research

Papers

(The median citation count of EMBO Reports is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
The Golgi microtubules regulate single cell durotaxis	162
Lamin A‐mediated nuclear lamina integrity is required for proper ciliogenesis	110
Aire‐dependent transcripts escape Raver2‐induced splice‐event inclusion in the thymic epithelium	109
The human touch	107
Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair	106
Functional skewing of TRIM21‐SIRT5 interplay dictates IL‐1β production in DSS‐induced colitis	97
Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice	96
E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2	94
Global and precise identification of functional miRNA targets in mESCs by integrative analysis	89
SCF ^FBXW7 regulates G2‐M progression through control of CCNL1	87
Concerns about academic freedom caused by the Russia–Ukraine War	85
The mission to ensure continued funding for excellent basic research	85
LGBTIQ+N	83
Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation	83
UBAP2L‐dependent coupling of PLK1 localization and stability during mitosis	77
CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection	74
Through an ecological lens	72
The post‐translational regulation of transcription factor EB (TFEB) in health and disease	71
SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3	71
XIAP promotes melanoma growth by inducing tumour neutrophil infiltration	65
TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment	65
Tissue resilience: lessons from social resilience	61
piRNA‐ and siRNA‐mediated transcriptional repression in Drosophila , mice, and yeast: new insights and biodiversity	60
lncRNA‐encoded pep‐AP attenuates the pentose phosphate pathway and sensitizes colorectal cancer cells to Oxaliplatin	59
METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m⁶A homeostasis	57

Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus	56
Dynamic chromatin association of IκBα is regulated by acetylation and cleavage of histone H4	54
Enhancing Spns2/S1P in macrophages alleviates hyperinflammation and prevents immunosuppression in sepsis	53
Dynamin‐like proteins mediate extracellular vesicle secretion in Mycobacterium tuberculosis	53
Animals do count	52
Striking the right balance between youth and experience	52
Resting natural killer cell homeostasis relies on tryptophan/NAD⁺ metabolism and HIF‐1α	51
SPTing across condensates: SEC‐mediated translocation of SPT complex from pausing condensates to elongation condensates	50
Zika virus alters centrosome organization to suppress the innate immune response	49
Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice	48
Functions of animal microRNA‐encoded peptides: the race is on!	47
Scalable RT‐LAMP‐based SARS‐CoV‐2 testing for infection surveillance with applications in pandemic preparedness	46
Tissue‐like environments shape functional interactions of HIV‐1 with immature dendritic cells	46
Energetic landscape of polycystin channel gating	46
Noncanonical Wnt signaling promotes colon tumor growth, chemoresistance and tumor fibroblast activation	45
The transcriptional regulator Sin3A balances IL‐17A and Foxp3 expression in primary CD4 T cells	45
Sci‐Con	45
Morphofunctional changes at the active zone during synaptic vesicle exocytosis	44
A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength	44
Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network	44
Hair follicle stem cell progeny heal blisters while pausing skin development	43
PRMT5 links lipid metabolism to contractile function of skeletal muscles	43
Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster	43
Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo	42
The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive‐strand R	42
Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis	42
IL‐21 has a critical role in establishing germinal centers by amplifying early B cell proliferation	41
Sequestration of LINE‐1 in cytosolic aggregates by MOV10 restricts retrotransposition	41
pH regulates hematopoietic stem cell potential via polyamines	41
Single‐cell analysis reveals dynamic changes of neural cells in developing human spinal cord	41
Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER‐phagy, and Collagen quality control	41
Bipolar‐associated miR‐499‐5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2	40
A Good Day for Helminths: how parasite‐derived GDH suppresses inflammatory responses	40
#IchbinHannah and the fight for permanent jobs for postdocs	40
Biparatopic sybodies neutralize SARS‐CoV‐2 variants of concern and mitigate drug resistance	40
Single cell clonal analysis identifies an AID ‐dependent pathway of plasma cell differentiation	39
Introducing quality measures in an academic research consortium	39
The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis	39
DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres	38
BTNL2 promotes colitis‐associated tumorigenesis in mice by regulating IL‐22 production	38
The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity	38
STAT5bis a key effector ofNRG‐1/ERBB4‐mediated myocardial growth	38
The regulation of human blastoid research	38
The B56α subunit of PP2A is necessary for mesenchymal stem cell commitment to adipocyte	37
Bclaf1 regulates c‐FLIP expression and protects cells from TNF‐induced apoptosis and tissue injury	37
Vitamin D receptor enhances NLRC4 inflammasome activation by promoting NAIPs–NLRC4 association	37
Specific N‐glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning	37
Viral diseases and the brain	37
A human coronavirus OC43‐derived polypeptide causes neuropathic pain	37
Tick‐borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2	36

GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1‐dependent manner	35
FOXM1 network in association with TREM1 suppression regulates NET formation in diabetic foot ulcers	35
A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation	35
ER ‐phagy: selective autophagy of the endoplasmic reticulum	35
Evolutionary remodelling of N‐terminal domain loops fine‐tunes SARS‐CoV‐2 spike	35
Autophagy orchestrates the crosstalk between cells and organs	35
Malaria parasites release vesicle subpopulations with signatures of different destinations	35
Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters	34
DJ‐1 depletion prevents immunoaging in T‐cell compartments	34
Phase‐separated foci of EML4‐ALK facilitate signalling and depend upon an active kinase conformation	33
Getting the message right	33
Fish faeces and ocean life	33
CDK9 and PP2A regulate RNA polymerase II transcription termination and coupled RNA maturation	33
Gold mining nature for natural products	33
Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation	32
The human GID complex engages two independent modules for substrate recruitment	32
CACGAACTACCCTAA	32
Tonic TNF conditioning of macrophages safeguards stimulus‐specific inflammatory responses	32
A need for recalibrating access and benefit sharing	32
Interaction with the CCT chaperonin complex limits APOBEC3A cytidine deaminase cytotoxicity	32
Inductive prediction in biology	32
Open reading frame dominance indicates protein‐coding potential of RNAs	32
Constructive correction	32
Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus	32
mPFC DUSP1 mediates adolescent cocaine exposure‐induced higher sensitivity to drug in adulthood	32
On predictions and laws in biological evolution	31
Powering on cGAMP mini factories	31
TMBIM5 is the Ca ²⁺ /H ⁺ antiporter of mammalian mitochondria	30
Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development	30
Isotope‐labeled amyloid‐β does not transmit to the brain in a prion‐like manner after peripheral administration	30
The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins	29
Ovol1/2 loss‐induced epidermal defects elicit skin immune activation and alter global metabolism	29
Understanding redundancy and resilience	29
Pericyte stem cells induce Ly6G⁺ cell accumulation and immunotherapy resistance in pancreatic cancer	29
Down on the farm	28
KIAA1429/VIRMA promotes breast cancer progression by m⁶A‐dependent cytosolic HAS2 stabilization	28
The need for sustainable leadership in academia	28
Intra‐epithelial non‐canonical Activin A signaling safeguards prostate progenitor quiescence	28
Mycobacterium tuberculosis : the honey badger of pathogens	28
Learning tricks from old dogs	28
Confusion	28
Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria	28
Evolution of pathogen virulence	27
Pervasive compartment‐specific regulation of gene expression during homeostatic synaptic scaling	27
HP1γ binding pre‐mRNA intronic repeats modulates RNA splicing decisions	26
Reducing oxidative protein folding alleviates senescence by minimizing ER‐to‐nucleus H₂O₂ release	26
Optogenetic control of YAP cellular localisation and function	26
A plea for the ultimate optimism	26
Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress	26
The Autophagy Receptor TAX1BP1 ( T6BP ) improves antigen presentation by MHC‐II molecules	26
A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection	26
Foxm1 regulates neural progenitor fate during spinal cord regeneration	26
PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability	26
NuRD‐independent Mi‐2 activity represses ectopic gene expression during neuronal maturation	26
Phosphorylation by casein kinase 2 enhances the interaction between ER‐phagy receptor TEX264 and ATG8 proteins	26
Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway	26
The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging	26
New model integrates innate responses, PML‐NB formation, epigenetic control and reactivation from latency	25
Confessions of a microscope hoarder	25
Circadian oscillation in primary cilium length by clock genes regulates fibroblast cell migration	25
Bench science	25
ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness	25
F‐domain valency determines outcome of signaling through the angiopoietin pathway	25
Scholars in peril: when being a scientist can land you in jail (or worse)	25
Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding	25
GM‐CSF suppresses antioxidant signaling and drives IL‐1β secretion through NRF2 downregulation	24
Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice	24
RNA polymerase II CTD is dispensable for transcription and required for termination in human cells	24
Rabaptin5 targets autophagy to damaged endosomes and Salmonella vacuoles via FIP200 and ATG16L1	24
An ULK1/2‐PXN mechanotransduction pathway suppresses breast cancer cell migration	24
LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1	24
Autism therapy at crossroads	24
CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B	24
Mitochondrial F ₁ F _O ATP synthase determines the local proton motive force at cristae rims	23
Diacylglycerols interact with the L2 lipidation site in TRPC3 to induce a sensitized channel state	23
BRD9 is a druggable component of interferon‐stimulated gene expression and antiviral activity	23
m6A methylation promotes white‐to‐beige fat transition by facilitating Hif1a translation	23
Rab21 regulates caveolin‐1‐mediated endocytic trafficking to promote immature neurite pruning	23
Hedgehog signaling can enhance glycolytic ATP production in the Drosophila wing disc	23
Cx43‐mediated sorting of miRNAs into extracellular vesicles	23

Dual control of dopamine in Drosophila myeloid‐like progenitor cell proliferation and regulation of lymph gland growth	23
IKKβ is required for the formation of the NLRP3 inflammasome	23
MAP kinase cascades in plant development and immune signaling	23
Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6‐dependent pathway	23
TPLATE complex‐dependent endocytosis attenuates CLAVATA1 signaling for shoot apical meristem maintenance	23
DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation	23
FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1	23
Waste management	23
We can do better	22
Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis	22
Descending dopaminergic pathway facilitates itch signal processing via activating spinal GRPR⁺ neurons	22
USP17 is required for peripheral trafficking of lysosomes	22
Transgenerational epigenetic information through the sperm	22
The mind of a scientist	22
Oxygen‐regulated post‐translation modifications as master signalling pathway in cells	22
Two redundant ubiquitin‐dependent pathways of BRCA1 localization to DNA damage sites	21
Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation	21
The Drosophila mitotic spindle orientation machinery requires activation, not just localization	21
Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation	21
LincRNA‐EPS impairs host antiviral immunity by antagonizing viral RNA–PKR interaction	21
The splicing‐regulatory lncRNA NTRAS sustains vascular integrity	21
Exosome‐like nanoparticles from Mulberry bark prevent DSS‐induced colitis via the AhR/COPS8 pathway	20
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1	20
Estrogen receptor alpha signaling in dendritic cells modulates autoimmune disease phenotype in mice	20
Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members	20
MOV10 recruits DCP2 to decap human LINE‐1 RNA by forming large cytoplasmic granules with phase separation properties	20
The chromatin factorROWcooperates withBEAF‐32 in regulating long‐range inducible genes	20
Endothelial‐immune crosstalk contributes to vasculopathy in nonalcoholic fatty liver disease	20
NPM1 ablation induces HSC aging and inflammation to develop myelodysplastic syndrome exacerbated by p53 loss	20
An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase	20
Structural study of UFL1‐UFC1 interaction uncovers the role of UFL1 N‐terminal helix in ufmylation	19
A trashed treasure	19
Keep biology weird	19
Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole	19
The perceived decline of “disruptive” science and technology	19
Alcodemia: are we training our students to be great thinkers or great drinkers?	19
Piwi/piRNAs control food intake by promoting neuropeptide F expression in locusts	19
miR‐183 and miR‐96 orchestrate both glucose and fat utilization in skeletal muscle	19
Differential roles of the fish chitinous membrane in gut barrier immunity and digestive compartments	19
Combining organotypic tissue culture with light‐sheet microscopy (OTCxLSFM) to study glioma invasion	19
Ethical aspects of GMO regulation in the EU	19
Lipid and protein content profiling of isolated native autophagic vesicles	19
Engineering a customizable antibacterial T6SS‐based platform in Vibrio natriegens	18
The cancer microbiome	18
The human FOXM1 homolog promotes basal progenitor cell proliferation and cortical folding in mouse	18
Bioenergetics of early life	18
The taste of vitamin C inDrosophila	18
The obesity‐linked human lncRNA AATBC stimulates mitochondrial function in adipocytes	18
Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere	18
MiR‐342 controls Mycobacterium tuberculosis susceptibility by modulating inflammation and cell death	18
Bassoon controls synaptic vesicle release via regulation of presynaptic phosphorylation and cAMP	18
SARS‐CoV‐2‐related bat virus behavior in human‐relevant models sheds light on the origin of COVID‐19	17
Lipin‐2 regulates the antiviral and anti‐inflammatory responses to interferon	17
The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties	17
Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing	17
Adult neural stem cells and neurogenesis are resilient to intermittent fasting	17
EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole	17
Plasmodium sporozoite disintegration during skin passage limits malaria parasite transmission	17
Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV	17
Intracellular growth of Brucella is mediated by Dps‐dependent activation of ferritinophagy	17
Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL‐1R/TLR signals	17
Once in a lifetime	17
Cancer‐cell‐secreted extracellular vesicles target p53 to impair mitochondrial function in muscle	17
Myddosome clustering in IL‐1 receptor signaling regulates the formation of an NF‐kB activating signalosome	17
Structural basis for specific inhibition of the highly sensitive ShHTL7 receptor	16
Metabolomics meets systems immunology	16
ALS ‐linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain‐of‐function	16
Retrotransposon insertions associated with risk of neurologic and psychiatric diseases	16
Linking transport and translation of mRNAs with endosomes and mitochondria	16
Trained immunity induced by high‐salt diet impedes stroke recovery	16
Another message from Intergalactic Bacterial Command	16
Scratching the ocean surface	16
hnRNP R negatively regulates transcription by modulating the association of P‐TEFb with 7SK and BRD4	16
Whole‐genome analysis of TET dioxygenase function in regulatory T cells	16
Osteoclasts adapt to physioxia perturbation through DNA demethylation	16
Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming	16
Frizzled receptors facilitate Tiki inhibition of Wnt signaling at the cell surface	16
The viral era	16
Cold cases and ancient trade routes	16
Candida albicans induces neutrophil extracellular traps and leucotoxic hypercitrullination via candidalysin	16
Lamarck redux and other false arguments against SARS‐CoV‐2 vaccination	16
Co‐evolution within the plant holobiont drives host performance	16
Centrosome linker protein C‐Nap1 maintains stem cells in mouse testes	16
Dengue virus NS1 protein conveys pro‐inflammatory signals by docking onto high‐density lipoproteins	16
Losing bigly	16
A short history of beer brewing	16
Immune–epithelial cell cross‐talk enhances antiviral responsiveness to SARS‐CoV‐2 in children	15
Mitochondria as emergency landing for abandoned peroxins	15
GPR15–C10ORF99 functional pairing initiates colonic Treg homing in amniotes	15
Threatened forests	15
Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors	15
Time for change in research careers	15
Metabolic routing maintains the unique fatty acid composition of phosphoinositides	15
The international of wisdom	15
Cryo‐EM structure of the octameric pore of Clostridium perfringens β‐toxin	15