OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Reports is 23. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
The mission to ensure continued funding for excellent basic research	211
Global and precise identification of functional miRNA targets in mESCs by integrative analysis	153
Functional skewing of TRIM21‐SIRT5 interplay dictates IL‐1β production in DSS‐induced colitis	152
LGBTIQ+N	151
Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus	141
Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair	137
E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2	132
Erratum To: The Golgi microtubules regulate single cell durotaxis	125
Dynamin‐like proteins mediate extracellular vesicle secretion in Mycobacterium tuberculosis	120
UBAP2L‐dependent coupling of PLK1 localization and stability during mitosis	102
SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3	88
Enhancing Spns2/S1P in macrophages alleviates hyperinflammation and prevents immunosuppression in sepsis	80
Through an ecological lens	78
CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection	76
Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation	69
The post‐translational regulation of transcription factor EB (TFEB) in health and disease	66
SCFFBXW7 regulates G2‐M progression through control of CCNL1 ubiquitination	66
METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m6A homeostasis	65
IL‐21 has a critical role in establishing germinal centers by amplifying early B cell proliferation	62
Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network	59
Zika virus alters centrosome organization to suppress the innate immune response	59
The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive‐strand RNA viruses	56
Morphofunctional changes at the active zone during synaptic vesicle exocytosis	54
Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice	54
Resting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF‐1α	51

Animals do count	51
Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo	50
Sequestration of LINE‐1 in cytosolic aggregates by MOV10 restricts retrotransposition	49
A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength	49
Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis	48
Noncanonical Wnt signaling promotes colon tumor growth, chemoresistance and tumor fibroblast activation	48
Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster	48
Striking the right balance between youth and experience	46
Tissue‐like environments shape functional interactions of HIV‐1 with immature dendritic cells	45
Scalable RT‐LAMP‐based SARS‐CoV‐2 testing for infection surveillance with applications in pandemic preparedness	44
The transcriptional regulator Sin3A balances IL‐17A and Foxp3 expression in primary CD4 T cells	44
SPTing across condensates: SEC‐mediated translocation of SPT complex from pausing condensates to elongation condensates	44
pH regulates hematopoietic stem cell potential via polyamines	44
PRMT5 links lipid metabolism to contractile function of skeletal muscles	44
Energetic landscape of polycystin channel gating	44
STAT5b is a key effector of NRG‐1/ERBB4‐mediated myocardial growth	43
The regulation of human blastoid research	42
Autophagy orchestrates the crosstalk between cells and organs	42
GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1‐dependent manner	41
Tick‐borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2	41
DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres	41
Introducing quality measures in an academic research consortium	39
Vitamin D receptor enhances NLRC4 inflammasome activation by promoting NAIPs–NLRC4 association	39
Malaria parasites release vesicle subpopulations with signatures of different destinations	39
Bipolar‐associated miR‐499‐5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2	38
FOXM1 network in association with TREM1 suppression regulates NET formation in diabetic foot ulcers	38
A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation	38
BTNL2 promotes colitis‐associated tumorigenesis in mice by regulating IL‐22 production	38
The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity	37
Evolutionary remodelling of N‐terminal domain loops fine‐tunes SARS‐CoV‐2 spike	37
The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis	37
ER‐phagy: selective autophagy of the endoplasmic reticulum	36
mPFC DUSP1 mediates adolescent cocaine exposure‐induced higher sensitivity to drug in adulthood	36
Single cell clonal analysis identifies an AID‐dependent pathway of plasma cell differentiation	36
Ovol1/2 loss‐induced epidermal defects elicit skin immune activation and alter global metabolism	36
Getting the message right	35
CDK9 and PP2A regulate RNA polymerase II transcription termination and coupled RNA maturation	35
Tonic TNF conditioning of macrophages safeguards stimulus‐specific inflammatory responses	34
TMBIM5 is the Ca2+/H+ antiporter of mammalian mitochondria	34
Constructive correction	34
The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins	34
Inductive prediction in biology	34
Gold mining nature for natural products	34
Pericyte stem cells induce Ly6G+ cell accumulation and immunotherapy resistance in pancreatic cancer	33
Confusion	33
Reducing oxidative protein folding alleviates senescence by minimizing ER‐to‐nucleus H2O2 release	33
Learning tricks from old dogs	32
Evolution of pathogen virulence	32
KIAA1429/VIRMA promotes breast cancer progression by m6A‐dependent cytosolic HAS2 stabilization	32
PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability	32

The Autophagy Receptor TAX1BP1 (T6BP) improves antigen presentation by MHC‐II molecules	32
The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging	31
NuRD‐independent Mi‐2 activity represses ectopic gene expression during neuronal maturation	31
Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress	31
Optogenetic control of YAP cellular localisation and function	30
GM‐CSF suppresses antioxidant signaling and drives IL‐1β secretion through NRF2 downregulation	30
Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding	30
Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway	30
ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness	30
An ULK1/2‐PXN mechanotransduction pathway suppresses breast cancer cell migration	29
Hedgehog signaling can enhance glycolytic ATP production in the Drosophila wing disc	29
Scholars in peril: when being a scientist can land you in jail (or worse)	29
CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B	29
LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1	29
Circadian oscillation in primary cilium length by clock genes regulates fibroblast cell migration	29
A plea for the ultimate optimism	29
Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6‐dependent pathway	29
Autism therapy at crossroads	28
Rab21 regulates caveolin‐1‐mediated endocytic trafficking to promote immature neurite pruning	28
Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation	28
RNA polymerase II CTD is dispensable for transcription and required for termination in human cells	28
FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1	28
DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation	28
Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice	28
TPLATE complex‐dependent endocytosis attenuates CLAVATA1 signaling for shoot apical meristem maintenance	28
The Drosophila mitotic spindle orientation machinery requires activation, not just localization	27
The mind of a scientist	27
Descending dopaminergic pathway facilitates itch signal processing via activating spinal GRPR+ neurons	27
Lipid and protein content profiling of isolated native autophagic vesicles	26
Differential roles of the fish chitinous membrane in gut barrier immunity and digestive compartments	26
Keep biology weird	26
Oxygen‐regulated post‐translation modifications as master signalling pathway in cells	26
Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation	26
The perceived decline of “disruptive” science and technology	26
The chromatin factor ROW cooperates with BEAF‐32 in regulating long‐range inducible genes	26
Combining organotypic tissue culture with light‐sheet microscopy (OTCxLSFM) to study glioma invasion	26
Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members	26
Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis	26
Structural study of UFL1‐UFC1 interaction uncovers the role of UFL1 N‐terminal helix in ufmylation	26
Ethical aspects of GMO regulation in the EU	26
We can do better	26
MOV10 recruits DCP2 to decap human LINE‐1 RNA by forming large cytoplasmic granules with phase separation properties	26
Estrogen receptor alpha signaling in dendritic cells modulates autoimmune disease phenotype in mice	25
EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole	24
A trashed treasure	24
The cancer microbiome	24
Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing	24
The obesity‐linked human lncRNA AATBC stimulates mitochondrial function in adipocytes	24
ALS‐linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain‐of‐function	24
Cancer‐cell‐secreted extracellular vesicles target p53 to impair mitochondrial function in muscle	23
The taste of vitamin C in Drosophila	23
Lipin‐2 regulates the antiviral and anti‐inflammatory responses to interferon	23
The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties	23
Intracellular growth of Brucella is mediated by Dps‐dependent activation of ferritinophagy	23
Once in a lifetime	23