EMBO Reports

Article	Citations
Antibiotic resistance and persistence—Implications for human health and treatment perspectives	242
The evolving landscape around genome editing in agriculture	118
AI revolutions in biology	113
PINK 1 phosphorylates Drp1 S616 to regulate mitophagy‐independent mitochondrial dynamics	108
In‐depth and 3‐dimensional exploration of the budding yeast phosphoproteome	102
Ageing, metabolism and the intestine	94
RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss	85
The interplay between DNA and histone methylation: molecular mechanisms and disease implications	82
Respiratory supercomplexes enhance electron transport by decreasing cytochrome c diffusion distance	78
Rapid endotheliitis and vascular damage characterize SARS‐CoV‐2 infection in a human lung‐on‐chip model	77
Cell cycle dynamics of lamina‐associated DNA	74
The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity	72
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development	72
Root endophyte induced plant thermotolerance by constitutive chromatin modification at heat stress memory gene loci	71
Histone acetyltransferase 1 is a succinyltransferase for histones and non‐histones and promotes tumorigenesis	68
SARS‐CoV‐2 evades immune detection in alveolar macrophages	66
Iron loss triggers mitophagy through induction of mitochondrial ferritin	63
Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish	63
ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion	63
Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca 2+ ‐dependent death of cancer cells	62
From deficit to dialogue in science communication	62
Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism	61
Fighting antibiotic resistance—strategies and (pre)clinical developments to find new antibacterials	61
Mitochondrial protein biogenesis in the synapse is supported by local translation	61
Fusobacterium nucleatum secretes amyloid‐like FadA to enhance pathogenicity	60

Mitophagy receptor FUNDC1 is regulated by PGC‐1α/NRF1 to fine tune mitochondrial homeostasis	59
Healthy soils for healthy plants for healthy humans	59
Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take	58
Mitochondrial transplantation—a possible therapeutic for mitochondrial dysfunction?	58
Transfer of LncRNA CRNDE in TAM‐derived exosomes is linked with cisplatin resistance in gastric cancer	58
Phospholipid transfer function of PTPIP51 at mitochondria‐associated ER membranes	58
ALIX and ceramide differentially control polarized small extracellular vesicle release from epithelial cells	58
N(6)‐methyladenosine‐binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay	58
Exosome‐like nanoparticles from Mulberry bark prevent DSS‐induced colitis via the AhR/COPS8 pathway	58
Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER‐phagy, and Collagen quality control	55
Systemic effects of mitochondrial stress	55
Epstein–Barr virus‐derived circular RNA LMP 2A induces stemness in EBV ‐associated gastric cancer	55
Transcription factor CDF4 promotes leaf senescence and floral organ abscission by regulating abscisic acid and reactive oxygen species pathways in Arabidopsis	54
Specific RNA interactions promote TDP‐43 multivalent phase separation and maintain liquid properties	52
Loss of TMEM 106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice	51
Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance	49
Aneuploid senescent cells activate NF‐κB to promote their immune clearance by NK cells	48
Fermentation for future food systems	48
Key phosphorylation sites in GPCR s orchestrate the contribution of β‐Arrestin 1 in ERK 1/2 activation	48
N‐glycosylation of PD‐1 promotes binding of camrelizumab	48
USP22 controls necroptosis by regulating receptor‐interacting protein kinase 3 ubiquitination	48
Mentoring minority trainees	47
MAP kinase cascades in plant development and immune signaling	47
Autoimmunity gene IRGM suppresses cGAS ‐ STING and RIG ‐I‐	47
Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease	47
Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction	46
Glucose uptake to guard cells via STP transporters provides carbon sources for stomatal opening and plant growth	46
A malectin‐like receptor kinase regulates cell death and pattern‐triggered immunity in soybean	46
TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease	45
Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish	44
HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle‐resident mesenchymal cells	44
Irgm2 and Gate‐16 cooperatively dampen Gram‐negative bacteria‐induced caspase‐11 response	44
The mitochondrial Ca 2+ uptake regulator, MICU1, is involved in cold stress‐induced ferroptosis	43
Curcumin prevents obesity by targeting TRAF4‐induced ubiquitylation in m 6 A‐dependent manner	43
Putting the brakes on phagocytosis: “don't‐eat‐me” signaling in physiology and disease	42
The 18S rRNA m 6 A methyltransferase METTL 5 promotes mouse embryonic stem cell differentiation	42
NeutrobodyPlex—monitoring SARS‐CoV‐2 neutralizing immune responses using nanobodies	41
Remodeling and activation mechanisms of outer arm dyneins revealed by cryo‐EM	41
Hsp90‐mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling	40
Nanotube‐like processes facilitate material transfer between photoreceptors	40
Dynamin‐related Irgm proteins modulate LPS‐induced caspase‐11 activation and septic shock	40
The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation	39
FAM111 protease activity undermines cellular fitness and is amplified by gain‐of‐function mutations in human disease	39
PPARα alleviates iron overload‐induced ferroptosis in mouse liver	39
Nesprin‐2 accumulates at the front of the nucleus during confined cell migration	39
Interferon‐induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20	38
MPK3/6‐induced degradation of ARR1/10/12 promotes salt tolerance in Arabidopsis	38
PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal‐to‐zygotic transition	38
The struggle of a good friend getting old: cellular senescence in viral responses and therapy	38
Best practices to ensure robust investigation of circular RNAs: pitfalls and tips	38

The phyB‐dependent induction of HY5 promotes iron uptake by systemically activating FER expression	37
Succinylation of H3K122 destabilizes nucleosomes and enhances transcription	37
Myf6/MRF4 is a myogenic niche regulator required for the maintenance of the muscle stem cell pool	37
H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing	37
Loss of TMEM 106B potentiates lysosomal and FTLD ‐like pathology in progranulin‐deficient mice	36
Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures	36
GSDMD drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for NETosis	36
CTCF shapes chromatin structure and gene expression in health and disease	36
Paternal age affects offspring via an epigenetic mechanism involving REST/NRSF	35
ER ‐phagy: selective autophagy of the endoplasmic reticulum	35
OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential	35
piRNA‐ and siRNA‐mediated transcriptional repression in Drosophila , mice, and yeast: new insights and biodiversity	35
Single‐cell analysis reveals dynamic changes of neural cells in developing human spinal cord	34
Alterations in mitochondrial morphology as a key driver of immunity and host defence	34
Nuclear envelope rupture and NET formation is driven by PKCα‐mediated lamin B disassembly	34
Calcium signaling induces a partial EMT	34
Chronic cold exposure enhances glucose oxidation in brown adipose tissue	34
Monitoring mitochondrial translation in living cells	34
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth	34
A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection	33
Intellectual disability‐associated gene ftsj1 is responsible for 2′‐O‐methylation of specific tRNAs	33
Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin‐deficient mice	33
Get closer and make hotspots: liquid–liquid phase separation in plants	32
Mitochondrial F 1 F O ATP synthase determines the local proton motive force at cristae rims	32
Fast news or fake news?	32
Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling	31
Regulation and inhibition of the DNA sensor cGAS	31
Phase‐separated foci of EML4‐ALK facilitate signalling and depend upon an active kinase conformation	31
Maintaining proteostasis under mechanical stress	30
The FUS gene is dual‐coding with both proteins contributing to FUS ‐mediated toxicity	30
Biparatopic sybodies neutralize SARS‐CoV‐2 variants of concern and mitigate drug resistance	29
PIDDosome‐induced p53‐dependent ploidy restriction facilitates hepatocarcinogenesis	29
Mild mitochondrial impairment enhances innate immunity and longevity through ATFS‐1 and p38 signaling	29
The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT –liver communication	29
CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage	28
Redox activation of ATM enhances GSNOR translation to sustain mitophagy and tolerance to oxidative stress	28
The ubiquitin ligation machinery in the defense against bacterial pathogens	28
The stress granule protein G3BP1 promotes pre‐condensation of cGAS to allow rapid responses to DNA	28
Health disinformation & social media	28
Linking transport and translation of mRNAs with endosomes and mitochondria	28
Transient Dux expression facilitates nuclear transfer and induced pluripotent stem cell reprogramming	28
CUL2LRR1, TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle	28
Atg1 kinase regulates autophagosome‐vacuole fusion by controlling SNARE bundling	28
TIFA has dual functions in Helicobacter pylori ‐induced classical and alternative NF‐κB pathways	28
SFRP1 modulates astrocyte‐to‐microglia crosstalk in acute and chronic neuroinflammation	28
Bardet–Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self‐tolerance	28
USP42 protects ZNRF3/RNF43 from R‐spondin‐dependent clearance and inhibits Wnt signalling	27
The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder	27
Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere	27
BioID reveals an ATG9A interaction with ATG13‐ATG101 in the degradation of p62/SQSTM1‐ubiquitin clusters	27
Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA	27
Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming	27
Neuronal lipolysis participates in PUFA‐mediated neural function and neurodegeneration	27
Micro RNA ‐195 controls MICU 1 expression and tumor growth in ovarian cancer	27
Histone methyltransferase DOT1L controls state‐specific identity during B cell differentiation	27
Alternative splicing coupled mRNA decay shapes the temperature‐dependent transcriptome	27
Homologous recombination and Mus81 promote replication completion in response to replication fork blockage	26
Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast	26
Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia	26
Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development	26
PLETHORA‐WOX5 interaction and subnuclear localization control Arabidopsis root stem cell maintenance	26
Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons	26
COVID ‐19 and misinformation	26
Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice	26
Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1	26
Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole	26
m6A methylation promotes white‐to‐beige fat transition by facilitating Hif1a translation	26
TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment	26
Plasmodium transcription repressor AP2‐O3 regulates sex‐specific identity of gene expression in female gametocytes	26
Iron‐induced NCOA4 condensation regulates ferritin fate and iron homeostasis	26
B1‐type cyclins control microtubule organization during cell division in Arabidopsis	25
Calcium regulation of stem cells	25
VEGF‐B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content	25
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1	25
Single‐cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland	25
Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity	25
The unfolded protein response links tumor aneuploidy to local immune dysregulation	25
lncRNA‐encoded pep‐AP attenuates the pentose phosphate pathway and sensitizes colorectal cancer cells to Oxaliplatin	25
Deubiquitinating enzymes UBP12 and UBP13 stabilize the brassinosteroid receptor BRI1	25
Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates	25

Quaking 5 suppresses TGF‐β‐induced EMT and cell invasion in lung adenocarcinoma	25
Influenza A viruses limit NLRP3‐NEK7‐complex formation and pyroptosis in human macrophages	25
βH‐spectrin is required for ratcheting apical pulsatile constrictions during tissue invagination	24
HOTAIR lncRNA promotes epithelial–mesenchymal transition by redistributing LSD1 at regulatory chromatin regions	24
Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains	24
Non‐redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression	24
A multifaceted cellular damage repair and prevention pathway promotes high‐level tolerance to β‐lactam antibiotics	24
Muscle‐derived exophers promote reproductive fitness	24
TET 2 promotes anti‐tumor immunity by governing G‐ MDSC s and CD 8 + T‐c	24
Amyloid aggregates accumulate in melanoma metastasis modulating YAP activity	23
Molecular networks of the FOXP2 transcription factor in the brain	23
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1	23
Emerging pathogen evolution	23
CDK inhibitor Palbociclib targets STING to alleviate autoinflammation	23
Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity	23
FAM111A induces nuclear dysfunction in disease and viral restriction	23
Differential regulation of glycinergic and GABAergic nanocolumns at mixed inhibitory synapses	23
So close, no matter how far: multiple paths connecting transcription to mRNA translation in eukaryotes	23
The androgen receptor depends on ligand‐binding domain dimerization for transcriptional activation	22
Quorum sensing governs a transmissive Legionella subpopulation at the pathogen vacuole periphery	22
Lipoic acid rejuvenates aged intestinal stem cells by preventing age‐associated endosome reduction	22
DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging	22
ALS ‐linked KIF5A ΔExon27 mutant causes neuronal toxicity through gain‐of‐function	22
TMBIM5 is the Ca 2+ /H + antiporter of mammalian mitochondria	22
Modelling of primary ciliary dyskinesia using patient‐derived airway organoids	22
MOAP‐1‐mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling	22
Function of the SNARE Ykt6 on autophagosomes requires the Dsl1 complex and the Atg1 kinase complex	22
Mobile late endosomes modulate peripheral endoplasmic reticulum network architecture	22
N ‐acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages	22
Actin filament oxidation by MICAL1 suppresses protections from cofilin‐induced disassembly	22
Exploring GPCR‐arrestin interfaces with genetically encoded crosslinkers	22
The power of saying no	22
IKKβ is required for the formation of the NLRP3 inflammasome	22
MYC promotes cancer progression by modulating m6A modifications to suppress target gene translation	22
Degradation of WTAP blocks antiviral responses by reducing the m 6 A levels of IRF3 and IFNAR1 mRNA	21
Phosphorylation by casein kinase 2 enhances the interaction between ER‐phagy receptor TEX264 and ATG8 proteins	21
MiR‐342 controls Mycobacterium tuberculosis susceptibility by modulating inflammation and cell death	21
Nitrate triggered phosphoproteome changes and a PIN2 phosphosite modulating root system architecture	21
SIRT3‐dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth	21
Toll‐like receptor 4 is activated by platinum and contributes to cisplatin‐induced ototoxicity	21
ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids	21
Pseudomonas aeruginosa survives in epithelia by ExoS‐mediated inhibition of autophagy and mTOR	21
Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation	21
Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters	21
Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1	21
PML‐NB‐dependent type I interferon memory results in a restricted form of HSV latency	21
Biodiversity crisis or sixth mass extinction?	21
Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells	21
Whole‐genome analysis of TET dioxygenase function in regulatory T cells	21
Non‐apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence	21
MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking	21
HP1 maintains protein stability of H3K9 methyltransferases and demethylases	21
PLK1 regulates centrosome migration and spindle dynamics in male mouse meiosis	20
From the freezer to the clinic	20
LGR 5 controls extracellular matrix production by stem cells in the developing intestine	20
A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation	20
MITOL promotes cell survival by degrading Parkin during mitophagy	20
G‐Quadruplexes act as sequence‐dependent protein chaperones	20
A cell atlas of adult muscle precursors uncovers early events in fibre‐type divergence in Drosophila	20
Dynamics of Staphylococcus aureus Cas9 in DNA target Association and Dissociation	20
Physical and functional interactome atlas of human receptor tyrosine kinases	20
Long non‐coding RNA ELDR enhances oral cancer growth by promoting ILF3‐cyclin E1 signaling	20
Chromatin accessibility dynamics during cell fate reprogramming	19
The actin modulator hMENA regulates GAS 6‐ AXL axis and pro‐tumor cancer/stromal cell cooperati	19
Dengue virus NS1 protein conveys pro‐inflammatory signals by docking onto high‐density lipoproteins	19
Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness	19
Long non‐coding RNA TINCR suppresses metastatic melanoma dissemination by preventing ATF4 translation	19
Modulation of phagosome phosphoinositide dynamics by a Legionella phosphoinositide 3‐kinase	19
HOIP limits anti‐tumor immunity by protecting against combined TNF and IFN‐gamma‐induced apoptosis	19
Pseudo‐repeats in doublecortin make distinct mechanistic contributions to microtubule regulation	19
Adaptive homeostasis and the p53 isoform network	19
Glial Hedgehog signalling and lipid metabolism regulate neural stem cell proliferation in Drosophila	19
Nsp16 shields SARS–CoV ‐2 from efficient MDA5 sensing and IFIT1 ‐mediated restriction	19
Using a bistable animal opsin for switchable and scalable optogenetic inhibition of neurons	19
The future of conferences, today	19
PEBP 1 suppresses HIV transcription and induces latency by inactivating MAPK / NF	19
The human GID complex engages two independent modules for substrate recruitment	19
Identification and characterization of in vitro expanded hematopoietic stem cells	19
Composition, organization and mechanisms of the transition zone, a gate for the cilium	18
A binary effector module secreted by a type VI secretion system	18
EVL regulates VEGF receptor‐2 internalization and signaling in developmental angiogenesis	18
UBXD8 mediates mitochondria‐associated degradation to restrain apoptosis and mitophagy	18
BAZ2A‐mediated repression via H3K14ac‐marked enhancers promotes prostate cancer stem cells	18
Engineering a customizable antibacterial T6SS‐based platform in Vibrio natriegens	18
Evolutionary remodelling of N‐terminal domain loops fine‐tunes SARS‐CoV‐2 spike	18
LncPSCA in the 8q24.3 risk locus drives gastric cancer through destabilizing DDX5	18
A simple reverse genetics method to generate recombinant coronaviruses	18
SHLD 2 promotes class switch recombination by preventing inactivating deletions within the Igh locus	18
EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics	18
Functional coordination of non‐myocytes plays a key role in adult zebrafish heart regeneration	17
MiR‐29 coordinates age‐dependent plasticity brakes in the adult visual cortex	17
ATF3 induces RAB7 to govern autodegradation in paligenosis, a conserved cell plasticity program	17
The moral status of human embryo‐like structures: potentiality matters?	17
Co‐evolution within the plant holobiont drives host performance	17
MYBL2 and ATM suppress replication stress in pluripotent stem cells	17