OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Reports is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Global and precise identification of functional miRNA targets in mESCs by integrative analysis	171
Lamin A‐mediated nuclear lamina integrity is required for proper ciliogenesis	121
Dynamin‐like proteins mediate extracellular vesicle secretion in Mycobacterium tuberculosis	114
Nlrp3 inflammasome activation in macrophages suffices for inducing autoinflammation in mice	111
METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m⁶A homeostasis	101
Aire‐dependent transcripts escape Raver2‐induced splice‐event inclusion in the thymic epithelium	99
Enhancing Spns2/S1P in macrophages alleviates hyperinflammation and prevents immunosuppression in sepsis	95
LGBTIQ+N	95
The Golgi microtubules regulate single cell durotaxis	89
Through an ecological lens	88
The post‐translational regulation of transcription factor EB (TFEB) in health and disease	87
The human touch	86
Concerns about academic freedom caused by the Russia–Ukraine War	83
TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment	81
E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2	80
Functional skewing of TRIM21‐SIRT5 interplay dictates IL‐1β production in DSS‐induced colitis	79
XIAP promotes melanoma growth by inducing tumour neutrophil infiltration	73
CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection	68
SCF ^FBXW7 regulates G2‐M progression through control of CCNL1	66
SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3	65
lncRNA‐encoded pep‐AP attenuates the pentose phosphate pathway and sensitizes colorectal cancer cells to Oxaliplatin	59
Equally potent: Nlrp3 mutation in macrophages or neutrophils is sufficient to drive autoinflammation	57
The mission to ensure continued funding for excellent basic research	57
UBAP2L‐dependent coupling of PLK1 localization and stability during mitosis	56
piRNA‐ and siRNA‐mediated transcriptional repression in Drosophila , mice, and yeast: new insights and biodiversity	56

Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair	55
Scalable RT‐LAMP‐based SARS‐CoV‐2 testing for infection surveillance with applications in pandemic preparedness	55
Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus	55
Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster	55
The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive‐strand R	54
Zika virus alters centrosome organization to suppress the innate immune response	54
Resting natural killer cell homeostasis relies on tryptophan/NAD⁺ metabolism and HIF‐1α	53
PRMT5 links lipid metabolism to contractile function of skeletal muscles	50
Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo	50
Single‐cell analysis reveals dynamic changes of neural cells in developing human spinal cord	49
Morphofunctional changes at the active zone during synaptic vesicle exocytosis	48
Tissue‐like environments shape functional interactions of HIV‐1 with immature dendritic cells	48
SPTing across condensates: SEC‐mediated translocation of SPT complex from pausing condensates to elongation condensates	47
Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis	47
Sequestration of LINE‐1 in cytosolic aggregates by MOV10 restricts retrotransposition	47
The transcriptional regulator Sin3A balances IL‐17A and Foxp3 expression in primary CD4 T cells	46
Sci‐Con	45
A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength	45
Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice	45
A Good Day for Helminths: how parasite‐derived GDH suppresses inflammatory responses	44
pH regulates hematopoietic stem cell potential via polyamines	44
Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network	44
Animals do count	43
Striking the right balance between youth and experience	43
Functions of animal microRNA‐encoded peptides: the race is on!	43
Noncanonical Wnt signaling promotes colon tumor growth, chemoresistance and tumor fibroblast activation	42
IL‐21 has a critical role in establishing germinal centers by amplifying early B cell proliferation	42
Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER‐phagy, and Collagen quality control	42
A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation	41
The regulation of human blastoid research	41
A human coronavirus OC43‐derived polypeptide causes neuropathic pain	41
FOXM1 network in association with TREM1 suppression regulates NET formation in diabetic foot ulcers	41
Energetic landscape of polycystin channel gating	41
Malaria parasites release vesicle subpopulations with signatures of different destinations	40
GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1‐dependent manner	40
DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres	40
#IchbinHannah and the fight for permanent jobs for postdocs	39
STAT5bis a key effector ofNRG‐1/ERBB4‐mediated myocardial growth	39
DJ‐1 depletion prevents immunoaging in T‐cell compartments	39
Bipolar‐associated miR‐499‐5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2	38
The GCN2/eIF2αK stress kinase regulates PP1 to ensure mitotic fidelity	38
Specific N‐glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning	36
Evolutionary remodelling of N‐terminal domain loops fine‐tunes SARS‐CoV‐2 spike	36
Single cell clonal analysis identifies an AID ‐dependent pathway of plasma cell differentiation	36
Tick‐borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2	36
Introducing quality measures in an academic research consortium	36
Viral diseases and the brain	36
The fin roundabout: Slit‐Robo and S1P signaling coordinate fin morphogenesis	36
Bclaf1 regulates c‐FLIP expression and protects cells from TNF‐induced apoptosis and tissue injury	35
Vitamin D receptor enhances NLRC4 inflammasome activation by promoting NAIPs–NLRC4 association	35

Biparatopic sybodies neutralize SARS‐CoV‐2 variants of concern and mitigate drug resistance	35
BTNL2 promotes colitis‐associated tumorigenesis in mice by regulating IL‐22 production	35
ER ‐phagy: selective autophagy of the endoplasmic reticulum	35
Histone crotonylation regulates neural stem cell fate decisions by activating bivalent promoters	35
Autophagy orchestrates the crosstalk between cells and organs	35
Isotope‐labeled amyloid‐β does not transmit to the brain in a prion‐like manner after peripheral administration	35
On predictions and laws in biological evolution	34
CACGAACTACCCTAA	34
Inductive prediction in biology	34
The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins	33
Fish faeces and ocean life	33
A need for recalibrating access and benefit sharing	33
Constructive correction	32
mPFC DUSP1 mediates adolescent cocaine exposure‐induced higher sensitivity to drug in adulthood	32
Pericyte stem cells induce Ly6G⁺ cell accumulation and immunotherapy resistance in pancreatic cancer	31
Gold mining nature for natural products	31
Ovol1/2 loss‐induced epidermal defects elicit skin immune activation and alter global metabolism	31
The human GID complex engages two independent modules for substrate recruitment	31
Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation	30
Powering on cGAMP mini factories	30
Interaction with the CCT chaperonin complex limits APOBEC3A cytidine deaminase cytotoxicity	30
Phase‐separated foci of EML4‐ALK facilitate signalling and depend upon an active kinase conformation	30
Open reading frame dominance indicates protein‐coding potential of RNAs	30
CDK9 and PP2A regulate RNA polymerase II transcription termination and coupled RNA maturation	30
Getting the message right	30
Tonic TNF conditioning of macrophages safeguards stimulus‐specific inflammatory responses	30
Understanding redundancy and resilience	30
TMBIM5 is the Ca ²⁺ /H ⁺ antiporter of mammalian mitochondria	30
Learning tricks from old dogs	30
Confusion	29
Reducing oxidative protein folding alleviates senescence by minimizing ER‐to‐nucleus H₂O₂ release	29
A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection	29
Phosphorylation by casein kinase 2 enhances the interaction between ER‐phagy receptor TEX264 and ATG8 proteins	28
The Autophagy Receptor TAX1BP1 ( T6BP ) improves antigen presentation by MHC‐II molecules	28
The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging	28
Evolution of pathogen virulence	28
Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria	28
NuRD‐independent Mi‐2 activity represses ectopic gene expression during neuronal maturation	28
Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress	27
Intra‐epithelial non‐canonical Activin A signaling safeguards prostate progenitor quiescence	27
Pervasive compartment‐specific regulation of gene expression during homeostatic synaptic scaling	27
Down on the farm	27
KIAA1429/VIRMA promotes breast cancer progression by m⁶A‐dependent cytosolic HAS2 stabilization	27
The need for sustainable leadership in academia	27
Scholars in peril: when being a scientist can land you in jail (or worse)	26
Rabaptin5 targets autophagy to damaged endosomes and Salmonella vacuoles via FIP200 and ATG16L1	26
Optogenetic control of YAP cellular localisation and function	26
Confessions of a microscope hoarder	26
Bench science	26
Foxm1 regulates neural progenitor fate during spinal cord regeneration	26
GM‐CSF suppresses antioxidant signaling and drives IL‐1β secretion through NRF2 downregulation	26
A plea for the ultimate optimism	26
PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability	26
Mitochondrial F ₁ F _O ATP synthase determines the local proton motive force at cristae rims	25
Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding	25
Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway	25
ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness	25
An ULK1/2‐PXN mechanotransduction pathway suppresses breast cancer cell migration	25
MAP kinase cascades in plant development and immune signaling	25
F‐domain valency determines outcome of signaling through the angiopoietin pathway	25
Circadian oscillation in primary cilium length by clock genes regulates fibroblast cell migration	25
RNA polymerase II CTD is dispensable for transcription and required for termination in human cells	24
Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice	24
m6A methylation promotes white‐to‐beige fat transition by facilitating Hif1a translation	24
Cx43‐mediated sorting of miRNAs into extracellular vesicles	24
Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6‐dependent pathway	24
BRD9 is a druggable component of interferon‐stimulated gene expression and antiviral activity	24
Dual control of dopamine in Drosophila myeloid‐like progenitor cell proliferation and regulation of lymph gland growth	24
Diacylglycerols interact with the L2 lipidation site in TRPC3 to induce a sensitized channel state	24
TPLATE complex‐dependent endocytosis attenuates CLAVATA1 signaling for shoot apical meristem maintenance	24
DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation	24
IKKβ is required for the formation of the NLRP3 inflammasome	24
CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B	23
The mind of a scientist	23
Rab21 regulates caveolin‐1‐mediated endocytic trafficking to promote immature neurite pruning	23
FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1	23
The Drosophila mitotic spindle orientation machinery requires activation, not just localization	23
LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1	23
Hedgehog signaling can enhance glycolytic ATP production in the Drosophila wing disc	23
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1	23

Waste management	23
Autism therapy at crossroads	23
Two redundant ubiquitin‐dependent pathways of BRCA1 localization to DNA damage sites	22
Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members	22
We can do better	22
MOV10 recruits DCP2 to decap human LINE‐1 RNA by forming large cytoplasmic granules with phase separation properties	22
Oxygen‐regulated post‐translation modifications as master signalling pathway in cells	21
Endothelial‐immune crosstalk contributes to vasculopathy in nonalcoholic fatty liver disease	21
LincRNA‐EPS impairs host antiviral immunity by antagonizing viral RNA–PKR interaction	21
Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation	21
Descending dopaminergic pathway facilitates itch signal processing via activating spinal GRPR⁺ neurons	21
Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis	21
USP17 is required for peripheral trafficking of lysosomes	21
Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation	20
The perceived decline of “disruptive” science and technology	20
Estrogen receptor alpha signaling in dendritic cells modulates autoimmune disease phenotype in mice	20
The splicing‐regulatory lncRNA NTRAS sustains vascular integrity	20
Lipid and protein content profiling of isolated native autophagic vesicles	20
Combining organotypic tissue culture with light‐sheet microscopy (OTCxLSFM) to study glioma invasion	20
Ethical aspects of GMO regulation in the EU	20
Exosome‐like nanoparticles from Mulberry bark prevent DSS‐induced colitis via the AhR/COPS8 pathway	20
Keep biology weird	20
miR‐183 and miR‐96 orchestrate both glucose and fat utilization in skeletal muscle	20
Piwi/piRNAs control food intake by promoting neuropeptide F expression in locusts	19
Differential roles of the fish chitinous membrane in gut barrier immunity and digestive compartments	19
A trashed treasure	19
Osteoclasts adapt to physioxia perturbation through DNA demethylation	19
Bassoon controls synaptic vesicle release via regulation of presynaptic phosphorylation and cAMP	19
Engineering a customizable antibacterial T6SS‐based platform in Vibrio natriegens	19
An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase	19
Structural study of UFL1‐UFC1 interaction uncovers the role of UFL1 N‐terminal helix in ufmylation	19
Intracellular growth of Brucella is mediated by Dps‐dependent activation of ferritinophagy	19
EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole	19
Co‐evolution within the plant holobiont drives host performance	19
NPM1 ablation induces HSC aging and inflammation to develop myelodysplastic syndrome exacerbated by p53 loss	19
Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere	19
Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole	19
Cancer‐cell‐secreted extracellular vesicles target p53 to impair mitochondrial function in muscle	19
Adult neural stem cells and neurogenesis are resilient to intermittent fasting	19
The chromatin factorROWcooperates withBEAF‐32 in regulating long‐range inducible genes	19