OOIR: Observatory of International Research

Papers

(The TQCC of Reproduction is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Specc1l deficiency leads to abnormal oocyte meiosis and reduced blastocyst development in mouse	140
Emodin improves glucose metabolism and ovarian function in PCOS mice via the HMGB1/TLR4/NF-κB molecular pathway	95
Naked mole rat ovaries allow investigation of ovarian reserve, in vitro germ cell expansion, and oocyte in vitro	90
A proposed model of a clock that governs the length of human pregnancy	83
Regional abundances of binder of sperm (BSP) proteins are negatively associated with the quality of frozen-thawed bovine spermatozoa	66
m6A methyltransferase METTL3 inhibits endometriosis by regulating alternative splicing of MIR17HG	64
REPRODUCTIVE HEALTH IN TRANS AND GENDER DIVERSE PATIENTS: Fertility related knowledge, attitudes, and decision-making among gender diverse youth – A narrative review	53
Reproductive effects of combined polycystic ovary syndrome model and high-fat diet: tracing inheritance	52
Impact of Real-life Environmental Exposures on Reproduction: Endocrine-disrupting chemicals, reproductive aging, and menopause	41
Superovulation-induced changes in murine ovarian perifollicular angiogenesis	39
Fertility Treatment and Preservation Options for Transgender and Gender Diverse People	38
A refined culture system of oocytes from early antral follicles promotes oocyte maturation and embryo development in cattle	36
Atrazine disorganises laminin formation and reduces cell numbers in the tammar testis during early differentiation	36
Ca2+ concentrations in mouse sperm mitochondria fluctuate according to the cytosol	31
Scientific contributions of Professor Sir Ian Wilmut	31
Spermatogonial depletion and a spermatogenesis defect in the Dp(16)1Yey mouse model of Down syndrome	29
Engineering stress-tolerant mammalian embryos via a functional trehalose transporter	29
High-lipid nutritional environment in different ontogenetic periods induce developmental programming of rat prostate at aging	27
Glucose metabolism disorder related to follicular fluid exosomal miR-122-5p in cumulus cells of endometriosis patients	24
Telomeres and oocyte maturation rate are not reduced by COVID-19 except in severe cases	24
TMEM119 links to ovarian endometriosis progression via MAPK-mediated suppression of ectopic endometrial stromal cell senescence	24
Single-cell transcriptomics reveals cytotrophoblast subtypes and senescence in recurrent spontaneous abortion	22
Asialoglycoprotein receptor 1 positively regulates PTGS2-induced inflammatory response in polycystic ovary syndrome via ERK1/2 pathway	21
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: The impact of polycystic ovary syndrome on reproductive health: a narrative review	21
Murine models of advanced maternal age: a systematic review and meta-analysis	21

Ram sperm and seminal plasma alter immune transcriptome and cytokine secretion in ovine cervical explants ex vivo	21
A scoping review regarding reproductive capacity modulation based on alpha-ketoglutarate supplementation	21
The press-assisted fusion scheme significantly mitigates the quantity of HVJ-E required in mitochondrial replacement techniques	21
Dynamics of gametes and embryos in the oviduct: what can in vivo imaging reveal?	21
The role of angiotensin II and relaxin in vascular adaptation to pregnancy	20
The effects of the activation of TLR2/TLR1 on in vitro angiogenesis in an immortalized ovine luteal endothelial cell line	20
SPERM FACTORS AND EGG ACTIVATION: Fertilization failure after human ICSI and the clinical potential of PLCZ1	18
Novel PLCZ1 compound heterozygous mutations indicate gene dosage effect involved in total fertilisation failure after ICSI	18
Ultrastructural cilia defects in multi-ciliated uterine glandular epithelial cells from women with reproductive failure	17
Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology	17
Regulation of testosterone synthesis in Leydig cells by ClC-2 chloride channel	17
Highly expressed lncRNA H19 in endometriosis promotes aerobic glycolysis and histone lactylation	17
Pregnancy preparation: redistribution of CCR7-positive cells in the rat uterus	16
Novel insight into CD90 mesenchymal stem cell marker in mouse endometrial stroma during embryo implantation	16
Immunohistochemical examination of the uteroplacental interface of cows on days 21, 31, 40, and 67 of gestation	16
Molecular functions of Mrhl lncRNA in mouse spermatogenesis	16
Comparative analysis of PI3K-AKT and MEK-ERK1/2 signaling-driven molecular changes in granulosa cells	16
mTORC1-dependent suppression of autophagic activity in somatic cell nuclear transfer mouse embryos	16
Pre-estrus progesterone does not affect post-estrus luminal metabolome in cross-bred beef cows	15
The reduction of oocytes and disruption of the meiotic prophase I in Fanconi anemia E-deficient mice	15
The effect and mechanism of Grim 19 on mouse sperm quality and testosterone synthesis	15
DCAF13 and RNF114 participate in the regulation of early porcine embryo development	15
Disrupted MOS signaling alters meiotic cell cycle regulation and the egg transcriptome	14
IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: A contemporary review of machine learning to predict adverse pregnancy outcomes from pharmaceuticals, including DDIs	14
Epigallocatechin-3-gallate mitigates postovulatory oocyte aging by reducing oxidative stress and promoting embryonic development	14
REPRODUCTIVE HEALTH IN TRANS AND GENDER DIVERSE PATIENTS: Mind the gap: a nationwide audit of LGBTQ+ inclusion in fertility care providers in the United Kingdom	14
Exosomal or follicular FNDC3A decreases FOLR1 mRNA abundance and progesterone and lactate synthesis in bovine granulosa cells	14
Reproductive Ageing: Declining translational capacity as a potential driver for oocyte meiotic instability	14
Investigating ticagrelor in a preclinical pipeline as a novel therapeutic to prevent preterm birth	14
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: The significance of functional adrenal hyperandrogenism in polycystic ovary syndrome across the lifespan	14
FXR maintains primordial follicle dormancy via regulating FoxO3 expression	14
Protamines: lessons learned from mouse models	14
Monoclonal antibody potentiating gonadotropin activity in vitro and in vivo in male and female rats and in ewes	13
IMPACT OF REAL-LIFE ENVIRONMENTAL EXPROSURES ON REPRODUCTION: Adverse impacts of particulate matter air pollution on female and male reproduction	13
miR-23b-3p regulates human endometrial epithelial cell adhesion implying a role in implantation	13
Involvement of the linker histone H1Foo in the regulation of oogenesis	12
A maternal ketogenic diet alters oviduct fluid nutrients and embryo histone acetylation in mice	12
L-Methionine enhances cryosurvival and antioxidant activity of boar sperm	12
PREGNANCY DISORDERS AND MATERNAL CONSEQUENCES: Postpartum mental health after medically complicated pregnancy	11
OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Sperm telomeres, oxidative stress, and infertility	11
Omne vivum ex ovo : the oocyte reprogramming and remodeling activities	11
The interaction between seminal plasma, sperm, and endometrium in inter- and intra-species breeding in equids	11
Characterization of ovarian progenitor cells for their potential to generate steroidogenic theca cells in vitro	11
Hedgehog signalling in solitary motile cilia: detection and role of hedgehog factors in sperm functions and in vitro fertilization	11
Hypoxia-mediated chemotaxis and residence of macrophage in decidua by secreting VEGFA and CCL2 during normal pregnancy	11
SPERM FACTORS AND EGG ACTIVATION: PLCzeta as the sperm factor that activates eggs: 20 years on	11
SPERM FACTORS AND EGG ACTIVATION: The structure and function relationship of sperm PLCZ1	11
Creatine promotes endometriosis progression by inducing M2 polarization of peritoneal macrophages	10
GRSF1 deficiency attenuates mitochondrial function in aging granulosa cells	10
Reproductive Ageing: Current insights and a potential role of NAD in the reproductive health of aging fathers and their children	10

METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner	10
Exogenous melatonin ameliorates embryo–maternal cross-talk in early pregnancy in sheep	10
Inhibition of HSP90AA1 induces abnormalities in bovine oocyte maturation and embryonic development	9
Changes to the reproductive microbiome of the brood pouch during male pregnancy in seahorses (Hippocampus abdominalis)	9
Identification of circular RNAs as regulators and noninvasive biomarkers for placenta accreta spectrum	9
Male reproductive tract extracellular vesicles display region-specific heterogeneity in mice	9
Exosomes of mesenchymal stem cells and PRP restore spermatogenesis in the rat model of non-obstructive azoospermia	9
PCSK9 involves in the high-fat diet-induced abnormal testicular function of male mice	9
Sex, puberty, and the gut microbiome	9
Single-cell multiomic analysis reveals methylome and transcriptome deviations following oocyte maturation in vitro	9
Whole-genome DNA methylation analysis of the sperm in relation to bull fertility	9
The effect of vitamin D (1,25-(OH)2-D3) on human theca and granulosa cell function	9
Blockade of T-type Ca2+ channels disrupts mitochondrial function and follicle development by inhibiting the PI3K/AKT pathway	9
PP1γ1 is unable to substitute for the mammal-specific PP1γ2 isoform to support male fertility and sperm function	9
IGFBP7 enhances trophoblast invasion via IGF-1R/c-Jun signaling in unexplained recurrent spontaneous abortion	9
Nicotine exposure disrupts placental development via the Notch signaling pathway	9
Drosophila AK-3, a homolog of human CKMT1B, is essential for spermiogenesis	9
Cordycepin suppresses steroidogenic acute regulatory protein expression by reducing SP1 in human granulosa-lutein cells	9
Selection for Developmental Speed Skews Sex Ratios and Metabolic Profiles in Bovine IVP Embryos	9
Involvement of oxidative stress in placental dysfunction, the pathophysiology of fetal death and pregnancy disorders	9
Special series on reproductive health in transgender and gender-diverse patients	9
Increased plugging latency in cycling epiERα −/− (Esr1 f/− Wnt7a Cre/+ ) mice	8
Role of the hypothalamus in ghrelin effects on reproduction: sperm function and sexual behavior in male mice	8
Processes involved in prostaglandin F2alpha autoamplification in heifers	8
TRPM4 contribution in mouse uterine contractions	8
Acknowledgement to reviewers	8
IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Impact of developmental exposures to endocrine-disrupting chemicals on pituitary gland reproductive function	8
The central role of pyruvate metabolism on the epigenetic maturation and transcriptional profile of bovine oocytes	8
Modulatory role of mTOR in trophoblast adaptive response in the early stage of placentation in sheep	8
Heterogeneous spectrum of CFTR gene mutations in Chinese patients with CAVD and the dilemma of genetic blocking strategy	8
Elucidating metformin action on the ovary and fertility in healthy mice	8
PREGNANCY DISORDERS AND MATERNAL CONSEQUENCES: Ethnic disparities in hypertensive disorders of pregnancy	8
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Gestational anti-Müllerian hormone and testosterone excess combined with maternal adiposity program for polycystic ovary syndrome	8
Sperm utilize tumor necrosis factor alpha to shut down a 2-methoxyestradiol nongenomic pathway that accelerates oviductal egg transport in the rat	8
Melatonin attenuates Drp1-mediated excessive mitochondrial fission through upregulation of SIRT1 in granulosa cells in PCOS	8
Mitochondrial uncoupling proteins regulate the metabolic function of human Sertoli cells	8
SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor	8
Guidelines for quantifying ovarian follicles: every follicle counts	8
Endometrial stromal cells from women with repeated implantation failure display impaired invasion towards trophoblastic spheroids	8
Membrane progesterone receptors mediate progesterone-stimulated glycogenolysis in the bovine uterine epithelium	7
Downregulation of CRHBP is associated with trophoblast invasion inhibition in recurrent pregnancy loss	7
Could the untapped potential of the reproductive tract microbiome hold the key to tackling heavy menstrual bleeding?	7
In silico -designed vitrification protocols: an approach to improve survival of in vitro produced-bovine embryos	7
Reproductive Ageing: Unlocking the secrets of reproductive longevity: the potential of social insects	7
IFNT stimulates lysosomal function via type I IFN signaling pathway in pregnant bovine leukocytes	7
Sertoli cells, but not testicular endothelial cells, contribute to optimized culture of spermatogonia in pigs	7
PREGNANCY DISORDERS AND MATERNAL CONSEQUENCES: Emerging viral infections during pregnancy: understanding the risks to maternal and fetal health	7
Placental leukocyte infiltration accompanies gestational changes induced by hyperthyroidism	7
Comparison of intra-ovarian metabolic environment between women with or without polycystic ovary syndrome undergoing in vitro fertilization	7
OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: The impact of oxidative stress on reproduction: a focus on gametogenesis and fertilization	7
Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis	7
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Long-term health outcomes in polycystic ovary syndrome	7
3D hUC-MSC spheroids exhibit superior resistance to autophagy and apoptosis of granulosa cells in POF rat model	7
Porcine-specific expression of the three functional CYP19 paralogs in early conceptus, placenta, and gonads	7
The history of interferon-stimulated genes in pregnant cattle, sheep, and pigs	7
Redundant roles of AKT1 and AKT2 in fertility, estrous cyclicity and endometrial gland development	7
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Polycystic ovary syndrome: an evolutionary metabolic adaptation	7
Cholesterol supports bovine granulosa cell inflammatory responses to lipopolysaccharide	7
Beneficial effects of melatonin on canine oocyte nuclear maturation via reduction of oxidative stress	7
Characterisation of pouch secretions from breeding Tasmanian devils	7
NSUN5 is essential for proper cell proliferation and differentiation of mouse preimplantation embryos	7