Nature Reviews Genetics

Article	Citations
High-resolution 3D genome characterization	1231
Quantifying the effect of reference genome choice	889
Cell interaction by multiplet sequencing	778
SCOPE-ing out eukaryotic 6mA	734
Decoding cell–cell communication using spatial transcriptomics	696
Sequencing to save the Kākāpō	629
Illuminating the human yolk sac through single-cell omics	579
Sex and age affect circadian gene expression	573
Dissecting the genetics of ovarian ageing	486
microRNAs as systemic regulators of ageing	354
Maverick — top gun of horizontal gene transfer	338
Efficient computation reveals rare CRISPR–Cas systems	330
Fighting fibrosis with transient CAR T cells	301
Spatial miRNomics: towards the integration of microRNAs in spatial biology	298
Diversity and consequences of structural variation in the human genome	295
Laterally mobile chromosomes	270
Towards gene therapy for Tay-Sachs disease	261
CRISPR systems go mini	242
The different faces of transcription factor sensitivity	225
Programmable DNA rearrangements using bridge RNAs	202
Promoting a new view of mitochondrial genome regulation	195
Chromatin loops stack up	191
Using cell-free DNA to infer gene expression	179
Neighbourly modulation of transcript isoforms	179
Getting organized with non-coding RNAs	175

Assigning phenotypes to essential human genes	173
The GLUE that holds omics layers together	169
Base editing takes a shot at disease in non-human primates	165
Explaining the male bias in cancers	160
Context-specific functions of chromatin remodellers in development and disease	157
A developmental exit from totipotency	155
Means, mechanisms and consequences of adenine methylation in DNA	148
Prioritizing the detection of rare pathogenic variants in population screening	143
Disentangling population structure in marine species	138
Weaponized genomics: potential threats to international and human security	134
Enhancing sustainable development through plant genetics	130
Genetic conflict and its resolution between the sexes	125
Single-cell expression profiling has its roots in in situ techniques	125
Challenges and best practices in omics benchmarking	122
Selection on synonymous sites: the unwanted transcript hypothesis	118
Genomic prediction of neoantigens: immunogenomics before NGS	117
The puzzling guppy Y chromosome	117
Widespread occurrence of circular RNA in eukaryotes	116
Tightening the (neural) net for protein structure prediction	114
Imprinted genes and the manipulation of parenting in mammals	113
Reverting to old theories of ageing with new evidence for the role of somatic mutations	112
Regulatory promoter architectures in the hands of thermodynamic modelling	111
The complex non-genetic inheritance of complex traits	110
SCENT defines non-coding disease mechanisms using single-cell multi-omics	108
The evolutionary tale of lactase persistence in humans	106
Including diverse populations enhances the discovery of type 2 diabetes loci	102
The evolution of modifier genes	101
How ancient genes form animal body plans	100
Genetics of glycosylation in mammalian development and disease	98
Pleiotropy, epistasis and the genetic architecture of quantitative traits	97
The evolution of DNA sequencing with microfluidics	95
DNA packaging by molecular motors: from bacteriophage to human chromosomes	94
Tandem repeat variation of human centromeres	92
A deep learning method to map tissue architecture	92
Deafness: from genetic architecture to gene therapy	91
Interrogating epigenetic mechanisms with chemically customized chromatin	91
New insights into genome folding by loop extrusion from inducible degron technologies	91
Transposable elements: McClintock’s legacy revisited	84
GETting at single-cell chromatin dynamics	84
Theranostic cells: emerging clinical applications of synthetic biology	83
Translating genomic advances into biodiversity conservation	83
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination	80
The therapeutic potential of circular RNAs	77
Harnessing deep learning for population genetic inference	75
Making sense of the ageing methylome	75
Pioneer factors — key regulators of chromatin and gene expression	71
Interpreting non-coding disease-associated human variants using single-cell epigenomics	70
DNA methylation in mammalian development and disease	69
Measuring biological age using omics data	69
Computational methods for analysing multiscale 3D genome organization	69

Autophagy genes in biology and disease	68
DNA methylation-based predictors of health: applications and statistical considerations	68
Biobanking with genetics shapes precision medicine and global health	67
Mining genomes to illuminate the specialized chemistry of life	65
Microbiome epidemiology and association studies in human health	64
Human organs-on-chips for disease modelling, drug development and personalized medicine	64
The FinnGen study: disease insights from a ‘bottlenecked’ population	62
WNT regulator controls stripe patterning	62
Spatial resolution of host–microbiome interactions	58
Mapping vertebrate brain evolution	57
Convergent evolution of prickles across crops	57
Profiling human-specific VNTR expansions	57
Global cooperation for a global pandemic	55
Packaging and delivery of genome-editing tools	55
Detecting ribosomal footprints in single cells	54
A comprehensive view of human RNAs	53
From genome to drug: the hidden story of diversity	52
Spatial mapping of translation in single cells	52
A panoramic view of mouse organogenesis	51
Testing the super-enhancer concept	50
Target-directed microRNA degradation in Drosophila	49
Genetic prediction of multi-omic traits	47
Genomic insights into conifer evolution	47
Chromatin loops facilitate co-regulation of paralogues	47
Pan-cancer atlas of intratumour heterogeneity	45
The origin of animals and fungi	44
Disentangling host–microbiota complexity through hologenomics	43
Opportunities and challenges of macrogenetic studies	42
Temporal modelling using single-cell transcriptomics	40
Mapping the minutiae of the human methylome	39
Rethinking nomenclature for interspecies cell fusions	37
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	37
Beyond assembly: the increasing flexibility of single-molecule sequencing technology	35
Predicting variant pathogenicity with AlphaMissense	33
A new era in functional genomics screens	33
tRNA dysregulation and disease	33
Epigenome plasticity in plants	32
Publisher Correction: Germline risk of clonal haematopoiesis	31
Author Correction: Functional genomics data: privacy risk assessment and technological mitigation	30
From LD-based mapping to GWAS	30
Towards improved genetic diagnosis of human differences of sex development	29
Changes in cell-cycle rate drive diverging cell fates	28
The magic and meaning of Mendel’s miracle	28
The Neanderthal inside us	28
Causal inference for epigenetic ageing	28
Gregor Mendel and the concepts of dominance and recessiveness	28
Reconstructing generation intervals over time	27
Rapid pathogen surveillance: field-ready sequencing solutions	27
Multifunctional histone variants in genome function	26
Next-generation data filtering in the genomics era	26
Exploring biodiversity through museomics	26
The lives of cells, recorded	25
Unveiling the expanding protein universe of life	25
Ethical governance for genomic data science in the cloud	24
Reshaping Waddington’s developmental landscape	23
Genome-scale models in human metabologenomics	23
Author Correction: Transposable elements: McClintock’s legacy revisited	23
Context-specific regulatory variants in precision medicine and agriculture	22
Prime editing sensors enable multiplexed genome editing	21
Implications of mitochondrial DNA mutations in human induced pluripotent stem cells	21
Generating specificity in genome regulation through transcription factor sensitivity to chromatin	19
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	18
Gene regulatory network inference in the era of single-cell multi-omics	18
Overlapping genes in natural and engineered genomes	18
Inborn errors of immunity: an expanding universe of disease and genetic architecture	18
More than a decade of genetic research on the Denisovans	17
Progress in toxicogenomics to protect human health	17
Integrating ELSI study teams in paediatric genomic research efforts	16
Gene therapy for deafness: we can do more	15
The nexus between RNA-binding proteins and their effectors	14
Dynamic alternative DNA structures in biology and disease	14
Methods and applications for single-cell and spatial multi-omics	14
Computational analysis of cancer genome sequencing data	14
Spatial epigenomics in single cells	13
Abiotic stress responses in plants	13
Biparental inheritance of mitochondrial DNA revisited	13
Incongruence in the phylogenomics era	13
Testing at scale during the COVID-19 pandemic	12
Best practices for single-cell analysis across modalities	12
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	11

CRISPR editing within microbial communities	11
Genetic histories from environmental genomes	10
Human DNA from a prehistoric artefact	10
Bridging the multi-omics gap	9
Transcriptional coupling of long-distance genes	9
Dysregulation of epigenetically induced cancers	9
Aneuploidy in the driving seat	8
Layering epigenomic and transcriptomic space	8
Viral protection from viruses	8
Ancient migration and the modern genome	8
Mapping dosage	7
Connecting noncoding variants to human traits	7
New cuts for CRISPR effectors	6
Corrupted USB1 fails to process microRNAs required for blood development	6
Scientific seeds of inspiration	6
The early days of transcriptome sequencing and functional genomics	6
In vivo editing of blood stem cells	6
Detecting pregnancy complications from blood	6
Shared genetic components of multimorbidity	6
Gene synthesis from a non-coding RNA	6
Beyond genetics for cancer evolution	5
Revealing gene function with statistical inference at single-cell resolution	5
Genomic landscape of cancer in racially and ethnically diverse populations	5
From Mendel’s laws to non-Mendelian inheritance	5
Regulation of the RNA polymerase II pre-initiation complex by its associated coactivators	5
Purple Tomatoes, Black Rice and Food Security	5
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	5
Mouse genome rewriting with human DNA for disease modelling	5
RNA barcoding: the catalyst for the single-cell revolution	5
Mini-colons unlock tumour development outside the body	5
Homozygosity mapping: a game-changer for autosomal recessive diseases	5
De novo genes: from non-genic to genic	4
Down memory lane — unravelling the puzzle of gene regulation	4
Foreseeing the principles of genome architecture	4
The continuum of transcription factor affinities	4
Vavilov’s law and phenotypes across species	4
Stochastic transitions as a major source of cancer heterogeneity	4
Stem cell-derived organoid models: defying the Hayflick limit	4
Mary Lyon and the birth of X-inactivation research	4
Publisher Correction: Sociotechnical safeguards for genomic data privacy	4
From Mendel to a Mendelian disorder: towards a cure for sickle cell disease	4
Addressing health disparities in cancer with genomics	4
Publisher Correction: How germ granules promote germ cell fate	4
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	3
Spatial biology of cancer evolution	3
The chromosome hoarding syndrome of (some) ferns and lycophytes	3
Single-cell genomics meets human genetics	3
The regulatory landscape of chromatin accessibility	3
Epigenetic ageing clocks: statistical methods and emerging computational challenges	3
Opportunities and challenges for the use of common controls in sequencing studies	3
The design and engineering of synthetic genomes	3
Genetics of substance use disorders in the era of big data	3
Single-cell omics meets organoid cultures	3
Intrinsically disordered regions as facilitators of the transcription factor target search	3
Building a catalogue of short tandem repeats in diverse populations	3
First glimpse of enhancers in gene regulation	3
Biological roles of adenine methylation in RNA	3
Thoughts on a legacy	2
Genetic variation across and within individuals	2
Controlling organoid gene expression with light	2
Single cell–cell communication	2
The biological and clinical significance of emerging SARS-CoV-2 variants	2
Pharmacogenomics: current status and future perspectives	2
Gene–environment interactions in human health	2
Real-time single-molecule imaging of transcriptional regulatory networks in living cells	2
Alu sequences promote long-distance relationships	2
The gene variant that helped put Latinxs in the 1000 genomes project	2
Predicting the effects of multigene perturbations	2
To the rescue by blocking cryptic splicing	2
RADARs and READRs for programmable RNA sensing	2
Cohesin and CTCF emerge as building blocks of 3D genome structure	2
Long-read sequencing of new Drosophila genomes	2
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	2
Genome assembly in the telomere-to-telomere era	2
Horizontal gene transfer in eukaryotes: aligning theory with data	2
Unequal global implementation of genomic newborn screening	2
Locking in a synthetic genetic code	2
Chromatin context affects DNA repair pathway	2
EpiDamID, a new single-cell multi-omics tool	2
Epigenomes get personal	2
Turning gene loss into phenotypic gain	2
Linking disease-associated genetic variants to cell types and processes	2
The origin and evolution of Wnt signalling	2
Targeted genome-modification tools and their advanced applications in crop breeding	2
Molecular mechanisms of transgenerational epigenetic inheritance	2
Non-coding RNAs in disease: from mechanisms to therapeutics	2
Mitochondrial DNA copy number and disease	2
Quantification of RNA modifications	2
Assembling vertebrate genomes	2
An essential phase transition in fly development	2
A diverse and inclusive human pangenome	2