Nature Reviews Genetics

Article	Citations
Single-cell expression profiling has its roots in in situ techniques	1151
Explaining the male bias in cancers	1024
The different faces of transcription factor sensitivity	834
The evolution of modifier genes	786
Disentangling population structure in marine species	597
Weaponized genomics: potential threats to international and human security	568
Imprinted genes and the manipulation of parenting in mammals	446
Interrogating epigenetic mechanisms with chemically customized chromatin	423
Microorganisms as architects of a sustainable future	355
Harnessing deep learning for population genetic inference	330
How evolution builds three morphs from one genome	322
Folding a broken genome: the versatile roles of cohesin in genome maintenance	321
Enhancing sustainable development through plant genetics	304
Pleiotropy, epistasis and the genetic architecture of quantitative traits	301
The evolution of DNA sequencing with microfluidics	257
Gene regulatory networks: from correlative models to causal explanations	250
Unveiling the expanding protein universe of life	240
The origin of animals and fungi	223
The unbearable presence of senescent cells in ageing	222
Cis-regulatory elements at cellular resolution	221
Changes in cell-cycle rate drive diverging cell fates	220
Molecular integration of seasonal temperature signals in flowering time control	218
The evolutionary foundations of transcriptional regulation in animals	216
Rapid pathogen surveillance: field-ready sequencing solutions	211
Long non-coding RNAs as orchestrators of dosage compensation	206

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	201
RNA polymerase II transcription compartments — from factories to condensates	196
More than a decade of genetic research on the Denisovans	195
Progress in toxicogenomics to protect human health	194
Best practices for single-cell analysis across modalities	179
Mapping dosage	157
Intrinsically disordered regions as facilitators of the transcription factor target search	151
Adaptation: by giant leaps or many tiny steps?	148
Mini-colons unlock tumour development outside the body	146
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	129
Non-retroviral RNA viruses in eukaryotic genomes	123
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	122
Genomic landscape of cancer in racially and ethnically diverse populations	119
Advancing the applications of liquid biopsies in oncology	119
Layering epigenomic and transcriptomic space	118
Annotating genomes at increased scale and resolution	114
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	110
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores	110
Revealing gene function with statistical inference at single-cell resolution	109
Targeted genome-modification tools and their advanced applications in crop breeding	108
Predicting the effects of multigene perturbations	107
The hidden diversity of tumours	103
Swapping genes within and beyond our bodies	102
Mate choice through a genomic lens	101
Single cell–cell communication	100
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	99
CHIPping away at the genetic aetiology of clonal haematopoiesis	97
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	96
Miller spreads and the power of observation	94
Cohesin and CTCF emerge as building blocks of 3D genome structure	93
Redefining cellular reprogramming with advanced genomic technologies	92
Epigenomes get personal	90
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	90
The origin and evolution of Wnt signalling	84
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	82
Clinical use of polygenic risk scores: current status, barriers and future directions	79
Global genomic diversity for All of Us	75
Genomic newborn screening for rare diseases	75
Fitness effects of mutations throughout evolution	73
Social shifts in spiders	73
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	73
Recoding genomes with programmed ribosomal frameshifting	70
Prime editing: redefining precision genome editing	68
Why geneticists should care about male infertility	68
High-throughput biochemistry in RNA sequence space: predicting structure and function	67
The diversification of methods for studying cell–cell interactions and communication	65
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	65
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	64
Effects of regulatory variants across pig tissues	64
Targeting and engineering long non-coding RNAs for cancer therapy	64

A digital marker for coronary artery disease	63
Microbial genomics for antimicrobial resistance ecology and action	62
A whole-genome shotgun approach to human reference genome sequencing	62
Exon junction complex modulates m6A distribution	61
Mosaic variegated aneuploidy in development, ageing and cancer	59
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	58
Navigating the pitfalls of mapping DNA and RNA modifications	56
TimeVault: a synthetic time capsule for transcriptome storage	56
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	55
The expanding diagnostic toolbox for rare genetic diseases	55
Sex-specific morphs: the genetics and evolution of intra-sexual variation	54
Divergence and conservation of the meiotic recombination machinery	52
Genomic surveillance for antimicrobial resistance — a One Health perspective	50
Genetics of circadian rhythms and sleep in human health and disease	50
Chromosomal instability as a driver of cancer progression	50
Genomics for monitoring and understanding species responses to global climate change	49
Bidirectional functional genomics using CRISPR-KOALA	47
Programmable DNA rearrangements using bridge RNAs	46
SCENT defines non-coding disease mechanisms using single-cell multi-omics	44
A developmental exit from totipotency	44
How ancient genes form animal body plans	43
microRNAs as systemic regulators of ageing	42
Prioritizing the detection of rare pathogenic variants in population screening	42
Revisiting retinal and macular degeneration in the genomics era	42
Harnessing evolution to infer protein networks	42
The evolutionary tale of lactase persistence in humans	42
New insights into genome folding by loop extrusion from inducible degron technologies	41
Context-specific functions of chromatin remodellers in development and disease	41
Tools and tactics for studying alternative splicing	39
Biobanking with genetics shapes precision medicine and global health	39
Functional synonymous mutations and their evolutionary consequences	39
Challenges and best practices in omics benchmarking	38
Translating genomic advances into biodiversity conservation	37
Packaging and delivery of genome-editing tools	36
Integrating ELSI study teams in paediatric genomic research efforts	36
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	35
Reading cell division histories from the methylome	35
Nascent transcription quantification with scFLUENT-seq	34
Author Correction: Transposable elements: McClintock’s legacy revisited	34
Context-specific regulatory variants in precision medicine and agriculture	33
The FinnGen study: disease insights from a ‘bottlenecked’ population	32
Single-cell four-omics with CHARM	30
Predicting gene expression from DNA sequence using deep learning models	30
Multifunctional histone variants in genome function	30
The lives of cells, recorded	29
Towards improved fine-mapping of candidate causal variants	29
The nexus between RNA-binding proteins and their effectors	28
Mary Lyon and the birth of X-inactivation research	25
Cell-type deconvolution methods for spatial transcriptomics	25
In vivo editing of blood stem cells	25
Methods and applications for single-cell and spatial multi-omics	25
Corrupted USB1 fails to process microRNAs required for blood development	24
Ancient migration and the modern genome	23
A codon-resolved view of subcellular translation with LOCL-TL	22
The continuum of transcription factor affinities	22
De novo genes: from non-genic to genic	21
Stem cell-derived organoid models: defying the Hayflick limit	20
The genetic basis of human height	20
The regulatory landscape of chromatin accessibility	20
Computational approaches for multimodal lineage tracing	19
Spatial architecture of development and disease	19
Monitoring biological effects of somatic cell genome editing	18
Single-cell genomics meets human genetics	18
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01	17
Biological roles of adenine methylation in RNA	17
The gene variant that helped put Latinxs in the 1000 genomes project	17
Transposable elements as catalysts of evolutionary innovation	17
Forensic genetics in the omics era	16
Endogenous retroviruses: unveiling new targets for cancer immunotherapy	16
Tandem repeats in the long-read sequencing era	16
Genetic variation across and within individuals	16
Author Correction: Forensic genetics in the omics era	16
Making sense of the polygenicity of complex traits	16
Sequencing-based analysis of microbiomes	15
Prime editing for precise and highly versatile genome manipulation	15
Plant pattern recognition receptors: from evolutionary insight to engineering	15
Cytoplasmic mRNA decay and quality control machineries in eukaryotes	14
Ancestral diversity in complex disease genetics: from discovery to translation	13
Single-cell trimodal profiling with scHiCAR	13
BANKSY: scalable cell typing and domain segmentation for spatial omics	12

How the waxing and waning of a mutation determines HIV treatment success	12
Tracking protein binding to cis-regulatory elements with PRINT	12
Current advances in primate genomics: novel approaches for understanding evolution and disease	12
Cryptic initiation drives transcriptional junk in ageing	11
Live long & prosper: evidence of evolutionary forces on lifespan	11
From clonality to complexity: a journey through microbial ecology and evolution	11
Determining variant effects with pooled prime editing	11
Genome-wide association testing beyond SNPs	10
Nuclear genome influences mitochondrial DNA	10
Dissecting pleiotropy to gain mechanistic insights into human disease	10
Mechanisms of DNA specificity in chromatin remodelling	10
Prompt-based bioinformatics: a new interface for multi-omics analysis	9
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	8
Plant pangenomes for crop improvement, biodiversity and evolution	8
Methods and applications of genome-wide profiling of DNA damage and rare mutations	8
Efficient computation reveals rare CRISPR–Cas systems	7
Measuring the effects of regulatory variants in an endogenous context	7
Tandem repeat variation of human centromeres	7
How classical genetics uncovered key determinants of TE silencing	7
High-resolution imaging of RNA and proteins in thick tissues using cycleHCR	7
Spatial miRNomics: towards the integration of microRNAs in spatial biology	7
Prospects for personalized cancer treatment in the era of single-cell sequencing	7
Deafness: from genetic architecture to gene therapy	7
Genetics of glycosylation in mammalian development and disease	6
Exploring biodiversity through museomics	6
The genetic foundations of convergent traits	6
Harnessing artificial intelligence to advance CRISPR-based genome editing technologies	6
Chromatin loops facilitate co-regulation of paralogues	6
Dynamic alternative DNA structures in biology and disease	6
An uneasy truce between population health and the gene pools within our bodies	6
From models to molecules: self-organized and instructed modes of developmental patterning	6
Harnessing lateral gene transfer and endosymbiosis for adaptation	6
Genetic influences on haematopoiesis	6
Gene regulatory network inference in the era of single-cell multi-omics	6
The regulation and function of post-transcriptional RNA splicing	6
Methodological opportunities in genomic data analysis to advance health equity	5
Pharmacogenomics: current status and future perspectives	5
Alu sequences promote long-distance relationships	5
Genetics of human telomere biology disorders	5
An evolutionary continuum between non-coding and coding DNA	5
The long reach of the Red Queen	5
The design and engineering of synthetic genomes	5
To the rescue by blocking cryptic splicing	5
Single-cell omics meets organoid cultures	5
Viral protection from viruses	5
Publisher Correction: How germ granules promote germ cell fate	5
Connecting noncoding variants to human traits	5
Systemic cell–cell communication in cancer	5
More than meets the eye(spot): evolution through co-option of developmental programmes	5
RNA barcoding: the catalyst for the single-cell revolution	5
Author Correction: Evolution and regulation of animal sex chromosomes	4
Engineering an oscillating gene circuit to delay cellular ageing	4
Emergence and evolution of protein-coding de novo genes	4
CROWN-seq reveals m6Am landscapes and transcription start site diversity	4
Selection on structural variation in the amylase locus	4
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	4
Understanding human placentation through spatial multiomics	4
When cellular reprogramming meets AI: towards de novo cell design	4
Unlocking the potential of pedigree genomics via precision governance	4
Not all co-repressors are equal	4
Identifying off-target effects of genome editing with Tracking-seq	4
A TAD refined for gene regulation	4
A call to action to scale up research and clinical genomic data sharing	4
Metabolic engineering of plant medicines	3
Regulatory genomics at biobank scales	3
Variant calling and benchmarking in an era of complete human genome sequences	3
Epistasis and co-adaptation in bacterial genome evolution	3
Time matters: circadian genetics and the molecular logic of human health and disease	3
Adapting systems biology to address the complexity of human disease in the single-cell era	3
RNA splicing — a central layer of gene regulation	3
Predictive evidence of the relevance of epigenetics to PTSD	3
Biomarker benchmarking	3
Collaborating at the nexus of genomics, humanities, social science and stakeholders	3
Sequencing and characterizing short tandem repeats in the human genome	3
Tracing the evolution of sequencing into the era of genomic medicine	3
A crossroads in the timeline of human evolution	3
The evolution of Mycobacterium tuberculosis as humans migrated out of Africa	3
Is enhancer-driven gene regulation all wrapped up?	3
Nuclear receptors — studying genes to understand hormones	3
SIMPLE-seq to decode DNA methylation dynamics in single cells	3
Revealing secrets of human genetic variation with population databases	3
Linking disease-associated genetic variants to cell types and processes	2
A diverse and inclusive human pangenome	2
Decoding human genetic variation using a synthetic paradigm	2
Regulatory genome annotation	2
Genome-scale models in human metabologenomics	2
The discovery of gene imprinting	2
A TRIP to understand gene regulation	2
From Mendel’s laws to non-Mendelian inheritance	2
High-throughput identification of aptamer–target pairs with SPARK-seq	2
Non-coding RNAs in disease: from mechanisms to therapeutics	2
A focus on single-cell omics	2
Locking in a synthetic genetic code	2
Mapping trait-associated cells with spatial transcriptomics	2
Interpretation, extrapolation and perturbation of single cells	2