Nature Reviews Genetics

Article	Citations
The different faces of transcription factor sensitivity	1382
Explaining the male bias in cancers	916
Single-cell expression profiling has its roots in in situ techniques	869
Tightening the (neural) net for protein structure prediction	853
Disentangling population structure in marine species	765
Enhancing sustainable development through plant genetics	678
SCOPE-ing out eukaryotic 6mA	660
Weaponized genomics: potential threats to international and human security	585
The evolution of modifier genes	448
Getting organized with non-coding RNAs	390
The evolution of DNA sequencing with microfluidics	384
Harnessing deep learning for population genetic inference	370
Means, mechanisms and consequences of adenine methylation in DNA	346
Pleiotropy, epistasis and the genetic architecture of quantitative traits	321
Interrogating epigenetic mechanisms with chemically customized chromatin	284
Imprinted genes and the manipulation of parenting in mammals	277
Genomic insights into conifer evolution	223
Unveiling the expanding protein universe of life	221
Rapid pathogen surveillance: field-ready sequencing solutions	215
The origin of animals and fungi	211
Testing the super-enhancer concept	207
Changes in cell-cycle rate drive diverging cell fates	204
RNA polymerase II transcription compartments — from factories to condensates	198
More than a decade of genetic research on the Denisovans	189
Progress in toxicogenomics to protect human health	182

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	182
Abiotic stress responses in plants	180
Best practices for single-cell analysis across modalities	175
CRISPR editing within microbial communities	159
Shared genetic components of multimorbidity	158
Mapping dosage	157
Aneuploidy in the driving seat	155
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	154
Mini-colons unlock tumour development outside the body	152
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	149
Genomic landscape of cancer in racially and ethnically diverse populations	144
Revealing gene function with statistical inference at single-cell resolution	141
Layering epigenomic and transcriptomic space	139
Intrinsically disordered regions as facilitators of the transcription factor target search	139
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	135
Targeted genome-modification tools and their advanced applications in crop breeding	125
Epigenomes get personal	124
Genetics of substance use disorders in the era of big data	124
Predicting the effects of multigene perturbations	124
The hidden diversity of tumours	123
CHIPping away at the genetic aetiology of clonal haematopoiesis	122
Swapping genes within and beyond our bodies	121
Miller spreads and the power of observation	121
Mate choice through a genomic lens	118
Fine-mapping causal variants — why finding ‘the one’ can be futile	115
Cohesin and CTCF emerge as building blocks of 3D genome structure	110
Retrotransposons: still mobile in humans	104
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	104
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	103
Single cell–cell communication	103
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	101
Genomic newborn screening for rare diseases	100
The origin and evolution of Wnt signalling	98
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	93
Social shifts in spiders	90
The final pieces of the human genome	87
Why geneticists should care about male infertility	86
Global genomic diversity for All of Us	84
Fitness effects of mutations throughout evolution	83
High-throughput biochemistry in RNA sequence space: predicting structure and function	82
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	80
The diversification of methods for studying cell–cell interactions and communication	79
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	79
Targeting and engineering long non-coding RNAs for cancer therapy	78
The potential of mitochondrial genome engineering	78
Effects of regulatory variants across pig tissues	77
A digital marker for coronary artery disease	77
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	77
Exon junction complex modulates m6A distribution	77
A whole-genome shotgun approach to human reference genome sequencing	76

Mosaic variegated aneuploidy in development, ageing and cancer	75
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	69
Divergence and conservation of the meiotic recombination machinery	69
Sex-specific morphs: the genetics and evolution of intra-sexual variation	68
Navigating the pitfalls of mapping DNA and RNA modifications	67
The expanding diagnostic toolbox for rare genetic diseases	67
Genomics for monitoring and understanding species responses to global climate change	66
Chromosomal instability as a driver of cancer progression	66
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	66
Genomic surveillance for antimicrobial resistance — a One Health perspective	63
Genetics of circadian rhythms and sleep in human health and disease	61
Using cell-free DNA to infer gene expression	58
Laterally mobile chromosomes	58
Programmable DNA rearrangements using bridge RNAs	54
How ancient genes form animal body plans	53
SCENT defines non-coding disease mechanisms using single-cell multi-omics	52
microRNAs as systemic regulators of ageing	51
A developmental exit from totipotency	51
The evolutionary tale of lactase persistence in humans	51
Prioritizing the detection of rare pathogenic variants in population screening	47
Context-specific functions of chromatin remodellers in development and disease	45
Functional synonymous mutations and their evolutionary consequences	45
Translating genomic advances into biodiversity conservation	45
New insights into genome folding by loop extrusion from inducible degron technologies	44
Challenges and best practices in omics benchmarking	42
Biobanking with genetics shapes precision medicine and global health	42
Author Correction: Transposable elements: McClintock’s legacy revisited	40
Theranostic cells: emerging clinical applications of synthetic biology	40
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	39
Context-specific regulatory variants in precision medicine and agriculture	36
Global cooperation for a global pandemic	36
The FinnGen study: disease insights from a ‘bottlenecked’ population	35
Integrating ELSI study teams in paediatric genomic research efforts	35
Packaging and delivery of genome-editing tools	34
The lives of cells, recorded	33
Cell-type deconvolution methods for spatial transcriptomics	33
Methods and applications for single-cell and spatial multi-omics	32
Predicting gene expression from DNA sequence using deep learning models	32
The nexus between RNA-binding proteins and their effectors	31
In vivo editing of blood stem cells	30
Multifunctional histone variants in genome function	30
The continuum of transcription factor affinities	30
tRNA dysregulation and disease	30
Homozygosity mapping: a game-changer for autosomal recessive diseases	30
Publisher Correction: Sociotechnical safeguards for genomic data privacy	29
Mary Lyon and the birth of X-inactivation research	29
Corrupted USB1 fails to process microRNAs required for blood development	27
First glimpse of enhancers in gene regulation	26
De novo genes: from non-genic to genic	26
Ancient migration and the modern genome	26
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	24
The genetic basis of human height	24
Stem cell-derived organoid models: defying the Hayflick limit	24
The regulatory landscape of chromatin accessibility	24
Single-cell genomics meets human genetics	22
Biological roles of adenine methylation in RNA	22
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01	22
Impact of genetic ancestry on viral infection response	20
EpiDamID, a new single-cell multi-omics tool	20
The gene variant that helped put Latinxs in the 1000 genomes project	18
Cytoplasmic mRNA decay and quality control machineries in eukaryotes	17
Interplay between chromatin marks in development and disease	17
Making sense of the polygenicity of complex traits	17
Tandem repeats in the long-read sequencing era	17
Publisher Correction: The relationship between genome structure and function	16
Endogenous retroviruses: unveiling new targets for cancer immunotherapy	16
Plant pattern recognition receptors: from evolutionary insight to engineering	14
Genetic variation across and within individuals	14
Sequencing-based analysis of microbiomes	14
The human genetic epidemiology of COVID-19	14
Tracking haplotypes to quantify genome erosion	13
BANKSY: scalable cell typing and domain segmentation for spatial omics	13
A vast potential genome editor toolbox	13
Prime editing for precise and highly versatile genome manipulation	13
Current advances in primate genomics: novel approaches for understanding evolution and disease	13
The genetics of obesity: from discovery to biology	12
Tracking protein binding to cis-regulatory elements with PRINT	11
DNA replication in cell fate reprogramming	11
Genome-wide association testing beyond SNPs	10
Live long & prosper: evidence of evolutionary forces on lifespan	10

Cryptic initiation drives transcriptional junk in ageing	10
How the waxing and waning of a mutation determines HIV treatment success	10
Determining variant effects with pooled prime editing	10
Nuclear genome influences mitochondrial DNA	10
Methods and applications of genome-wide profiling of DNA damage and rare mutations	9
High-resolution imaging of RNA and proteins in thick tissues using cycleHCR	9
Plant pangenomes for crop improvement, biodiversity and evolution	9
Dissecting the genetics of ovarian ageing	9
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	9
Efficient computation reveals rare CRISPR–Cas systems	9
Measuring the effects of regulatory variants in an endogenous context	8
Tandem repeat variation of human centromeres	8
Genetics of glycosylation in mammalian development and disease	8
Neighbourly modulation of transcript isoforms	8
Spatial miRNomics: towards the integration of microRNAs in spatial biology	8
Exploring biodiversity through museomics	7
DNA methylation-based predictors of health: applications and statistical considerations	7
Chromatin loops facilitate co-regulation of paralogues	7
Deafness: from genetic architecture to gene therapy	7
Opportunities and challenges of macrogenetic studies	6
Gene regulatory network inference in the era of single-cell multi-omics	6
An uneasy truce between population health and the gene pools within our bodies	6
The regulation and function of post-transcriptional RNA splicing	6
Gregor Mendel and the concepts of dominance and recessiveness	6
Dynamic alternative DNA structures in biology and disease	6
Foreseeing the principles of genome architecture	5
Detecting pregnancy complications from blood	5
Viral protection from viruses	5
Publisher Correction: How germ granules promote germ cell fate	5
Beyond genetics for cancer evolution	5
Connecting noncoding variants to human traits	5
Single-cell omics meets organoid cultures	5
Transcriptional coupling of long-distance genes	5
To the rescue by blocking cryptic splicing	4
The design and engineering of synthetic genomes	4
Navigating the pitfalls of applying machine learning in genomics	4
Systemic cell–cell communication in cancer	4
RNA barcoding: the catalyst for the single-cell revolution	4
Pharmacogenomics: current status and future perspectives	4
Context-specific Polycomb mechanisms in development	4
Methodological opportunities in genomic data analysis to advance health equity	4
Alu sequences promote long-distance relationships	4
An evolving hypothesis in autoimmune disease genetics	4
Charting the world’s microbiomes	3
Genetics of human telomere biology disorders	3
Fetal growth: a family affair	3
Selection on structural variation in the amylase locus	3
Author Correction: The origin of human mutation in light of genomic data	3
Oncogenesis by phase separation	3
Adapting systems biology to address the complexity of human disease in the single-cell era	3
Engineering an oscillating gene circuit to delay cellular ageing	3
Drug delivery systems for RNA therapeutics	3
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	3
A TAD refined for gene regulation	3
Biomarker benchmarking	3
Variant calling and benchmarking in an era of complete human genome sequences	3
Metabolic engineering of plant medicines	3
CROWN-seq reveals m6Am landscapes and transcription start site diversity	3
Tuning mutagenesis by functional outcome	3
Not all co-repressors are equal	3
The biological and clinical significance of emerging SARS-CoV-2 variants	3
Identifying off-target effects of genome editing with Tracking-seq	3
Sex differences of oestradiol-mediated gene expression	3
A body-wide view of somatic mutations	3
RNA splicing — a central layer of gene regulation	3
A call to action to scale up research and clinical genomic data sharing	3
The root cause of shoot-borne roots	3
Understanding human placentation through spatial multiomics	3
DNA Typewriter	2
The effects of loss of Y chromosome on male health	2
The genetics of human performance	2
The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus	2
Sequencing to save the Kākāpō	2
Target-directed microRNA degradation in Drosophila	2
Human organs-on-chips for disease modelling, drug development and personalized medicine	2
Computational methods for analysing multiscale 3D genome organization	2
Measuring biological age using omics data	2
Histone post-translational modifications — cause and consequence of genome function	2
Nuclear receptors — studying genes to understand hormones	2
Revealing secrets of human genetic variation with population databases	2
SIMPLE-seq to decode DNA methylation dynamics in single cells	2
Maverick — top gun of horizontal gene transfer	2
Author Correction: Functional genomics data: privacy risk assessment and technological mitigation	2
Mapping vertebrate brain evolution	2
Gene therapy for deafness: we can do more	2
Illuminating the human yolk sac through single-cell omics	2
Sequencing and characterizing short tandem repeats in the human genome	2
A crossroads in the timeline of human evolution	2
Predictive evidence of the relevance of epigenetics to PTSD	2
Fighting fibrosis with transient CAR T cells	2
Including diverse populations enhances the discovery of type 2 diabetes loci	2
Ethical governance for genomic data science in the cloud	2
Genetic prediction of multi-omic traits	2
DNA methylation in mammalian development and disease	2
The complex non-genetic inheritance of complex traits	2