Nature Reviews Genetics

Article	Citations
The biological and clinical significance of emerging SARS-CoV-2 variants	774
Abiotic stress responses in plants	762
mRNAs, proteins and the emerging principles of gene expression control	598
Deciphering cell–cell interactions and communication from gene expression	595
Long-read human genome sequencing and its applications	556
Drug delivery systems for RNA therapeutics	450
The genetics of obesity: from discovery to biology	444
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics	434
Human organs-on-chips for disease modelling, drug development and personalized medicine	392
RNA-binding proteins in human genetic disease	363
The epitranscriptome beyond m6A	358
Histone post-translational modifications — cause and consequence of genome function	284
The evolving metabolic landscape of chromatin biology and epigenetics	258
Testing at scale during the COVID-19 pandemic	258
A decade of advances in transposon-insertion sequencing	235
Phylogenetic tree building in the genomic age	232
Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics	229
Polygenic adaptation: a unifying framework to understand positive selection	215
Methods and applications for single-cell and spatial multi-omics	215
Measuring and interpreting transposable element expression	214
Molecular mechanisms of transgenerational epigenetic inheritance	193
Genetics meets proteomics: perspectives for large population-based studies	192
Towards population-scale long-read sequencing	169
Best practices for single-cell analysis across modalities	166
The relationship between genome structure and function	164

The epigenetic basis of cellular heterogeneity	163
The emerging landscape of spatial profiling technologies	155
Molecular and evolutionary processes generating variation in gene expression	155
Gene therapy using haematopoietic stem and progenitor cells	151
Reprogramming the genetic code	149
Prime editing for precise and highly versatile genome manipulation	148
COMPASS and SWI/SNF complexes in development and disease	147
Transposable elements shape the evolution of mammalian development	140
Emerging mechanisms of cell competition	138
Enhancer redundancy in development and disease	137
Alternative splicing as a source of phenotypic diversity	133
The influence of evolutionary history on human health and disease	133
Extreme heterogeneity of human mitochondrial DNA from organelles to populations	127
Measuring biological age using omics data	126
Autophagy genes in biology and disease	124
Haematopoietic stem cell self-renewal in vivo and ex vivo	122
The road ahead in genetics and genomics	121
Active turnover of DNA methylation during cell fate decisions	117
Navigating the pitfalls of applying machine learning in genomics	114
Advancing the use of genome-wide association studies for drug repurposing	112
Mining genomes to illuminate the specialized chemistry of life	111
A new era in functional genomics screens	110
Host–parasite co-evolution and its genomic signature	109
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination	105
Redefining fundamental concepts of transcription initiation in bacteria	99
Host genetics and infectious disease: new tools, insights and translational opportunities	99
Gene regulatory programmes of tissue regeneration	98
Obtaining genetics insights from deep learning via explainable artificial intelligence	95
Gene drives gaining speed	94
Making sense of the ageing methylome	87
Biological roles of adenine methylation in RNA	87
Genetic load: genomic estimates and applications in non-model animals	86
The genomics of coloration provides insights into adaptive evolution	84
From molecules to populations: appreciating and estimating recombination rate variation	84
Exploring human genomic diversity with gnomAD	83
The Human Genome Project changed everything	80
Clinical cancer genomic profiling	77
Characterizing cis-regulatory elements using single-cell epigenomics	76
Epigenome plasticity in plants	76
Single-cell atlases: shared and tissue-specific cell types across human organs	75
Generation of extracellular morphogen gradients: the case for diffusion	75
The importance of genomic variation for biodiversity, ecosystems and people	74
The roles of microRNAs in mouse development	72
DNA methylation-based predictors of health: applications and statistical considerations	72
Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic	71
African genetic diversity and adaptation inform a precision medicine agenda	69
Responsible, practical genomic data sharing that accelerates research	68
Temporal modelling using single-cell transcriptomics	68
Polygenic scores in biomedical research	68
The human genetic epidemiology of COVID-19	67

Mechanical regulation of chromatin and transcription	67
microRNAs in action: biogenesis, function and regulation	67
Genetic engineering of T cells for immunotherapy	66
Advances and opportunities in malaria population genomics	65
Primary cilia as dynamic and diverse signalling hubs in development and disease	64
Interplay between chromatin marks in development and disease	64
Genetic innovations in animal–microbe symbioses	64
tRNA dysregulation and disease	63
Parental nucleosome segregation and the inheritance of cellular identity	63
Genetics of substance use disorders in the era of big data	62
The potential of mitochondrial genome engineering	61
Statistical mechanics meets single-cell biology	60
Genetics of circadian rhythms and sleep in human health and disease	60
Overlapping genes in natural and engineered genomes	58
Pharmacogenomics: current status and future perspectives	56
Opportunities and challenges of macrogenetic studies	54
The spatial organization of transcriptional control	54
Cross-species RNA-seq for deciphering host–microbe interactions	54
Probing the dynamic RNA structurome and its functions	52
Testing the super-enhancer concept	52
Genetics of human telomere biology disorders	52
Maternal H3K27me3-dependent autosomal and X chromosome imprinting	52
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	50
Gene regulatory network inference in the era of single-cell multi-omics	50
Dynamic alternative DNA structures in biology and disease	50
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects	49
Means, mechanisms and consequences of adenine methylation in DNA	49
Theranostic cells: emerging clinical applications of synthetic biology	49
Organization and expression of the mammalian mitochondrial genome	48
Generating specificity in genome regulation through transcription factor sensitivity to chromatin	48
Germline risk of clonal haematopoiesis	47
Decoding disease: from genomes to networks to phenotypes	46
Spatial biology of cancer evolution	45
Origins of human disease: the chrono-epigenetic perspective	44
Sociotechnical safeguards for genomic data privacy	44
Context-specific Polycomb mechanisms in development	44
Engineering synthetic RNA devices for cell control	43
Computational analysis of cancer genome sequencing data	43
Discovering and validating cancer genetic dependencies: approaches and pitfalls	42
Disentangling host–microbiota complexity through hologenomics	41
HIV-1 and human genetic variation	40
Examining the evidence for extracellular RNA function in mammals	40
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	39
RNA: a double-edged sword in genome maintenance	37
Mutation–selection balance and compensatory mechanisms in tumour evolution	37
Extrachromosomal DNA amplifications in cancer	37
Engineering 3D genome organization	37
Molecular mechanisms of environmental exposures and human disease	37
Towards improved genetic diagnosis of human differences of sex development	37
New insights into genome folding by loop extrusion from inducible degron technologies	33
Soma-to-germline RNA communication	31
How digital tools can advance quality and equity in genomic medicine	31
Variant calling and benchmarking in an era of complete human genome sequences	31
Principles and methods for transferring polygenic risk scores across global populations	30
Genomic newborn screening for rare diseases	28
The origin of human mutation in light of genomic data	27
Purple Tomatoes, Black Rice and Food Security	26
The genetics of human performance	26
Transposable elements in mammalian chromatin organization	25
Non-coding RNAs in disease: from mechanisms to therapeutics	25
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	24
Deafness: from genetic architecture to gene therapy	23
Incongruence in the phylogenomics era	22
The nexus between RNA-binding proteins and their effectors	22
Sex-specific morphs: the genetics and evolution of intra-sexual variation	21
Microbiome epidemiology and association studies in human health	21
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	20
Single-cell genomics meets human genetics	19
RNA modifications in physiology and disease: towards clinical applications	18
Transitioning single-cell genomics into the clinic	17
Perfect and imperfect views of ultraconserved sequences	17
Mendelian inheritance revisited: dominance and recessiveness in medical genetics	16
Reaching completion for GTEx	16
Towards a physical understanding of developmental patterning	15
From systems to structure — using genetic data to model protein structures	15
African ancient DNA research requires robust ethics and permission protocols	15
Functional genomics data: privacy risk assessment and technological mitigation	15
Current advances in primate genomics: novel approaches for understanding evolution and disease	14
Beyond assembly: the increasing flexibility of single-molecule sequencing technology	14
Widespread occurrence of circular RNA in eukaryotes	14

Genetics of human brain development	13
Opportunities and challenges for the use of common controls in sequencing studies	13
Genetic determinism, essentialism and reductionism: semantic clarity for contested science	13
Biparental inheritance of mitochondrial DNA revisited	13
Regulation of the RNA polymerase II pre-initiation complex by its associated coactivators	13
Repetitive DNA: genomic dark matter matters	13
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	12
Addressing health disparities in cancer with genomics	12
The TOPMed genomic resource for human health	12
Navigating the pitfalls of mapping DNA and RNA modifications	11
Genomic surveillance for antimicrobial resistance — a One Health perspective	11
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	11
Fine-mapping causal variants — why finding ‘the one’ can be futile	9
Interpreting non-coding disease-associated human variants using single-cell epigenomics	9
Prioritizing the detection of rare pathogenic variants in population screening	8
Shaping faces: genetic and epigenetic control of craniofacial morphogenesis	8
The mutation rate as an evolving trait	8
Computational methods for analysing multiscale 3D genome organization	7
SHARE-seq reveals chromatin potential	7
Gregor Mendel and the concepts of dominance and recessiveness	7
The power of large-scale exome sequencing	7
Navigating bottlenecks and trade-offs in genomic data analysis	7
High-throughput biochemistry in RNA sequence space: predicting structure and function	6
Divergence and conservation of the meiotic recombination machinery	6
The magic and meaning of Mendel’s miracle	6
Genomics for monitoring and understanding species responses to global climate change	6
Author Correction: Polygenic adaptation: a unifying framework to understand positive selection	6
The transition from genomics to phenomics in personalized population health	5
Implications of mitochondrial DNA mutations in human induced pluripotent stem cells	5
Steering and controlling evolution — from bioengineering to fighting pathogens	5
Genomic prediction of neoantigens: immunogenomics before NGS	5
CRISPR–Cas13 targets circRNAs	5
The diversification of methods for studying cell–cell interactions and communication	4
Publisher Correction: The genomics of coloration provides insights into adaptive evolution	4
Real-time single-molecule imaging of transcriptional regulatory networks in living cells	4
The FinnGen study: disease insights from a ‘bottlenecked’ population	4
Resolving the roles of structural variants	4
Detecting pregnancy complications from blood	4
Getting organized with non-coding RNAs	4
Mitochondrial DNA variants in genomic data: diagnostic uplifts and predictive implications	3
Mate choice through a genomic lens	3
Author Correction: The evolving metabolic landscape of chromatin biology and epigenetics	3
Inborn errors of immunity: an expanding universe of disease and genetic architecture	3
Harnessing deep learning for population genetic inference	3
Context-specific functions of chromatin remodellers in development and disease	3
Sequencing and characterizing short tandem repeats in the human genome	3
Quantifying gene duplication	3
Publisher Correction: The relationship between genome structure and function	3
Predicting variant pathogenicity with AlphaMissense	3
From LD-based mapping to GWAS	3
Host genetics of coronavirus infection	3
Author Correction: Emerging mechanisms of cell competition	3
Genome-scale single-cell CRISPR screens	3
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	3
Homozygosity mapping: a game-changer for autosomal recessive diseases	3
Pan-cancer atlas of intratumour heterogeneity	3
Rethinking nomenclature for interspecies cell fusions	3
Pioneer factors — key regulators of chromatin and gene expression	3
A body-wide view of somatic mutations	2
Complex targeted sequencing in real time	2
The origin and evolution of Wnt signalling	2
New tools for transcriptome-wide mapping of m6A	2
Aneuploidy in the driving seat	2
From Mendel to a Mendelian disorder: towards a cure for sickle cell disease	2
microRNAs as systemic regulators of ageing	2
Imprinted genes and the manipulation of parenting in mammals	2
In vivo RNA base editing with circular RNAs	2
Traversing industry and academia in biomedicine: the best of both worlds?	2
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	2
Capturing transposases for new proteins	2
Layering epigenomic and transcriptomic space	2
More than a decade of genetic research on the Denisovans	2
Selection on synonymous sites: the unwanted transcript hypothesis	2
Dissecting the genetics of ovarian ageing	2
Genomic outbreak surveillance in resource-poor settings	2
A platform for RNA virus cloning	2
The final pieces of the human genome	2
Reconciliation between high yield and disease resistance	2
CRISPR editing within microbial communities	2
Publisher Correction: Sociotechnical safeguards for genomic data privacy	2
Genomic insights into conifer evolution	2
Base editing takes a shot at disease in non-human primates	2
Reverting to old theories of ageing with new evidence for the role of somatic mutations	2
Interrogating epigenetic mechanisms with chemically customized chromatin	1
Giant genomes of lungfish	1
Spatial epigenomics in single cells	1
The puzzling guppy Y chromosome	1
Publisher Correction: Mutation–selection balance and compensatory mechanisms in tumour evolution	1
Transposable elements: McClintock’s legacy revisited	1
First glimpse of enhancers in gene regulation	1
The origin of animals and fungi	1
Disentangling population structure in marine species	1
Human cell-lineage imbalances	1
Vavilov’s law and phenotypes across species	1
African cattle adaptations	1