Nature Reviews Genetics

Article	Citations
The different faces of transcription factor sensitivity	1332
High-resolution 3D genome characterization	910
Explaining the male bias in cancers	845
Single-cell expression profiling has its roots in in situ techniques	819
Tightening the (neural) net for protein structure prediction	748
Disentangling population structure in marine species	652
Enhancing sustainable development through plant genetics	641
The evolution of DNA sequencing with microfluidics	628
SCOPE-ing out eukaryotic 6mA	553
Weaponized genomics: potential threats to international and human security	419
The evolution of modifier genes	367
Getting organized with non-coding RNAs	363
Interrogating epigenetic mechanisms with chemically customized chromatin	358
Imprinted genes and the manipulation of parenting in mammals	331
Means, mechanisms and consequences of adenine methylation in DNA	301
Harnessing deep learning for population genetic inference	278
Mining genomes to illuminate the specialized chemistry of life	266
Pleiotropy, epistasis and the genetic architecture of quantitative traits	213
Genomic insights into conifer evolution	206
Unveiling the expanding protein universe of life	204
Rapid pathogen surveillance: field-ready sequencing solutions	200
The origin of animals and fungi	198
Changes in cell-cycle rate drive diverging cell fates	196
Progress in toxicogenomics to protect human health	190
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	182

More than a decade of genetic research on the Denisovans	182
Best practices for single-cell analysis across modalities	175
Testing the super-enhancer concept	175
Abiotic stress responses in plants	169
CRISPR editing within microbial communities	169
Shared genetic components of multimorbidity	154
Layering epigenomic and transcriptomic space	148
Revealing gene function with statistical inference at single-cell resolution	147
Mapping dosage	145
Aneuploidy in the driving seat	145
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	144
Mini-colons unlock tumour development outside the body	143
Genomic landscape of cancer in racially and ethnically diverse populations	134
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	134
Genetics of substance use disorders in the era of big data	132
Intrinsically disordered regions as facilitators of the transcription factor target search	131
Targeted genome-modification tools and their advanced applications in crop breeding	125
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	121
Single cell–cell communication	121
Epigenomes get personal	119
Predicting the effects of multigene perturbations	119
The hidden diversity of tumours	117
CHIPping away at the genetic aetiology of clonal haematopoiesis	116
Miller spreads and the power of observation	115
Swapping genes within and beyond our bodies	114
Fine-mapping causal variants — why finding ‘the one’ can be futile	113
Mate choice through a genomic lens	113
Cohesin and CTCF emerge as building blocks of 3D genome structure	107
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	102
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	101
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	99
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	99
Retrotransposons: still mobile in humans	98
Genomic newborn screening for rare diseases	97
The origin and evolution of Wnt signalling	95
Social shifts in spiders	91
Why geneticists should care about male infertility	86
The final pieces of the human genome	86
Fitness effects of mutations throughout evolution	84
Global genomic diversity for All of Us	84
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	82
The diversification of methods for studying cell–cell interactions and communication	77
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	76
The potential of mitochondrial genome engineering	74
Effects of regulatory variants across pig tissues	74
Targeting and engineering long non-coding RNAs for cancer therapy	74
High-throughput biochemistry in RNA sequence space: predicting structure and function	74
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	73
A digital marker for coronary artery disease	71
Exon junction complex modulates m6A distribution	71

A whole-genome shotgun approach to human reference genome sequencing	70
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	68
Sex-specific morphs: the genetics and evolution of intra-sexual variation	67
Mosaic variegated aneuploidy in development, ageing and cancer	66
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	66
Genomic surveillance for antimicrobial resistance — a One Health perspective	65
Divergence and conservation of the meiotic recombination machinery	65
Navigating the pitfalls of mapping DNA and RNA modifications	64
Genomics for monitoring and understanding species responses to global climate change	62
Genetics of circadian rhythms and sleep in human health and disease	62
The expanding diagnostic toolbox for rare genetic diseases	61
Chromosomal instability as a driver of cancer progression	59
Laterally mobile chromosomes	59
Using cell-free DNA to infer gene expression	58
Programmable DNA rearrangements using bridge RNAs	57
How ancient genes form animal body plans	56
SCENT defines non-coding disease mechanisms using single-cell multi-omics	55
The evolutionary tale of lactase persistence in humans	51
microRNAs as systemic regulators of ageing	50
Prioritizing the detection of rare pathogenic variants in population screening	50
A developmental exit from totipotency	49
Translating genomic advances into biodiversity conservation	48
Challenges and best practices in omics benchmarking	46
Functional synonymous mutations and their evolutionary consequences	43
Theranostic cells: emerging clinical applications of synthetic biology	42
Biobanking with genetics shapes precision medicine and global health	42
Author Correction: Transposable elements: McClintock’s legacy revisited	40
Context-specific functions of chromatin remodellers in development and disease	40
New insights into genome folding by loop extrusion from inducible degron technologies	40
Global cooperation for a global pandemic	39
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	39
Context-specific regulatory variants in precision medicine and agriculture	38
Publisher Correction: Germline risk of clonal haematopoiesis	37
Integrating ELSI study teams in paediatric genomic research efforts	36
Multifunctional histone variants in genome function	34
Predicting gene expression from DNA sequence using deep learning models	33
The FinnGen study: disease insights from a ‘bottlenecked’ population	33
The lives of cells, recorded	31
Cell-type deconvolution methods for spatial transcriptomics	31
Packaging and delivery of genome-editing tools	31
The nexus between RNA-binding proteins and their effectors	31
Methods and applications for single-cell and spatial multi-omics	30
tRNA dysregulation and disease	30
In vivo editing of blood stem cells	29
The continuum of transcription factor affinities	28
Homozygosity mapping: a game-changer for autosomal recessive diseases	28
De novo genes: from non-genic to genic	28
Mary Lyon and the birth of X-inactivation research	26
First glimpse of enhancers in gene regulation	26
Publisher Correction: Sociotechnical safeguards for genomic data privacy	26
Corrupted USB1 fails to process microRNAs required for blood development	26
Ancient migration and the modern genome	24
The genetic basis of human height	23
The regulatory landscape of chromatin accessibility	22
Stem cell-derived organoid models: defying the Hayflick limit	22
Single-cell genomics meets human genetics	21
Biological roles of adenine methylation in RNA	21
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	20
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01	20
Impact of genetic ancestry on viral infection response	19
EpiDamID, a new single-cell multi-omics tool	19
The gene variant that helped put Latinxs in the 1000 genomes project	18
Endogenous retroviruses: unveiling new targets for cancer immunotherapy	17
Tandem repeats in the long-read sequencing era	17
Plant pattern recognition receptors: from evolutionary insight to engineering	16
Cytoplasmic mRNA decay and quality control machineries in eukaryotes	16
Sequencing-based analysis of microbiomes	15
Prime editing for precise and highly versatile genome manipulation	15
The human genetic epidemiology of COVID-19	15
Publisher Correction: The relationship between genome structure and function	15
Interplay between chromatin marks in development and disease	14
Genetic variation across and within individuals	14
A vast potential genome editor toolbox	13
BANKSY: scalable cell typing and domain segmentation for spatial omics	13
Tracking haplotypes to quantify genome erosion	13
Current advances in primate genomics: novel approaches for understanding evolution and disease	12
The genetics of obesity: from discovery to biology	12
Tracking protein binding to cis-regulatory elements with PRINT	11
How the waxing and waning of a mutation determines HIV treatment success	11
DNA replication in cell fate reprogramming	11

Methods and applications of genome-wide profiling of DNA damage and rare mutations	9
Genome-wide association testing beyond SNPs	9
Nuclear genome influences mitochondrial DNA	9
Live long & prosper: evidence of evolutionary forces on lifespan	9
Plant pangenomes for crop improvement, biodiversity and evolution	9
Genetics of glycosylation in mammalian development and disease	8
Neighbourly modulation of transcript isoforms	8
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	8
Spatial miRNomics: towards the integration of microRNAs in spatial biology	8
Dissecting the genetics of ovarian ageing	8
Cryptic initiation drives transcriptional junk in ageing	8
High-resolution imaging of RNA and proteins in thick tissues using cycleHCR	8
Tandem repeat variation of human centromeres	8
Efficient computation reveals rare CRISPR–Cas systems	8
Deafness: from genetic architecture to gene therapy	7
Chromatin loops facilitate co-regulation of paralogues	7
DNA methylation-based predictors of health: applications and statistical considerations	7
An uneasy truce between population health and the gene pools within our bodies	7
Exploring biodiversity through museomics	7
The regulation and function of post-transcriptional RNA splicing	6
Gene regulatory network inference in the era of single-cell multi-omics	6
Gregor Mendel and the concepts of dominance and recessiveness	6
Dynamic alternative DNA structures in biology and disease	6
Opportunities and challenges of macrogenetic studies	6
Detecting pregnancy complications from blood	5
Foreseeing the principles of genome architecture	5
Viral protection from viruses	5
Single-cell omics meets organoid cultures	5
Connecting noncoding variants to human traits	5
Transcriptional coupling of long-distance genes	5
Beyond genetics for cancer evolution	5
Publisher Correction: How germ granules promote germ cell fate	5
Pharmacogenomics: current status and future perspectives	4
Systemic cell–cell communication in cancer	4
Alu sequences promote long-distance relationships	4
RNA barcoding: the catalyst for the single-cell revolution	4
To the rescue by blocking cryptic splicing	4
An evolving hypothesis in autoimmune disease genetics	4
The design and engineering of synthetic genomes	4
Methodological opportunities in genomic data analysis to advance health equity	4
Context-specific Polycomb mechanisms in development	4
Not all co-repressors are equal	3
Drug delivery systems for RNA therapeutics	3
The root cause of shoot-borne roots	3
Metabolic engineering of plant medicines	3
Tuning mutagenesis by functional outcome	3
The biological and clinical significance of emerging SARS-CoV-2 variants	3
Fetal growth: a family affair	3
Engineering an oscillating gene circuit to delay cellular ageing	3
Identifying off-target effects of genome editing with Tracking-seq	3
Selection on structural variation in the amylase locus	3
Variant calling and benchmarking in an era of complete human genome sequences	3
Genetics of human telomere biology disorders	3
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	3
Charting the world’s microbiomes	3
Understanding human placentation through spatial multiomics	3
A TAD refined for gene regulation	3
Adapting systems biology to address the complexity of human disease in the single-cell era	3
CROWN-seq reveals m6Am landscapes and transcription start site diversity	3
Sex differences of oestradiol-mediated gene expression	3
Navigating the pitfalls of applying machine learning in genomics	3
SIMPLE-seq to decode DNA methylation dynamics in single cells	2
A body-wide view of somatic mutations	2
A call to action to scale up research and clinical genomic data sharing	2
The effects of loss of Y chromosome on male health	2
Sequencing and characterizing short tandem repeats in the human genome	2
Measuring biological age using omics data	2
Human organs-on-chips for disease modelling, drug development and personalized medicine	2
Maverick — top gun of horizontal gene transfer	2
The complex non-genetic inheritance of complex traits	2
Nuclear receptors — studying genes to understand hormones	2
Revealing secrets of human genetic variation with population databases	2
Oncogenesis by phase separation	2
Author Correction: The origin of human mutation in light of genomic data	2
The origin of human mutation in light of genomic data	2
DNA methylation in mammalian development and disease	2
Mapping vertebrate brain evolution	2
Computational methods for analysing multiscale 3D genome organization	2
Sequencing to save the Kākāpō	2
Fighting fibrosis with transient CAR T cells	2
A crossroads in the timeline of human evolution	2
The genetics of human performance	2
Biomarker benchmarking	2
RNA splicing — a central layer of gene regulation	2
DNA Typewriter	2
Histone post-translational modifications — cause and consequence of genome function	2
Genetic prediction of multi-omic traits	2
Including diverse populations enhances the discovery of type 2 diabetes loci	2
Illuminating the human yolk sac through single-cell omics	2
Towards gene therapy for Tay-Sachs disease	2
Predictive evidence of the relevance of epigenetics to PTSD	2
The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus	2