Nature Reviews Genetics

Article	Citations
Single-cell expression profiling has its roots in in situ techniques	1038
Explaining the male bias in cancers	944
The different faces of transcription factor sensitivity	775
The evolution of modifier genes	723
Disentangling population structure in marine species	561
Weaponized genomics: potential threats to international and human security	524
Imprinted genes and the manipulation of parenting in mammals	500
Enhancing sustainable development through plant genetics	419
Interrogating epigenetic mechanisms with chemically customized chromatin	405
Pleiotropy, epistasis and the genetic architecture of quantitative traits	388
Gene regulatory networks: from correlative models to causal explanations	383
Microorganisms as architects of a sustainable future	327
The evolution of DNA sequencing with microfluidics	309
Harnessing deep learning for population genetic inference	292
Unveiling the expanding protein universe of life	288
Rapid pathogen surveillance: field-ready sequencing solutions	284
The origin of animals and fungi	259
The evolutionary foundations of transcriptional regulation in animals	231
Progress in toxicogenomics to protect human health	230
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	228
The unbearable presence of senescent cells in ageing	227
Long non-coding RNAs as orchestrators of dosage compensation	211
Cis-regulatory elements at cellular resolution	207
Changes in cell-cycle rate drive diverging cell fates	201
Best practices for single-cell analysis across modalities	199

RNA polymerase II transcription compartments — from factories to condensates	199
More than a decade of genetic research on the Denisovans	189
Mapping dosage	188
Mini-colons unlock tumour development outside the body	185
Non-retroviral RNA viruses in eukaryotic genomes	182
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	178
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores	173
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	173
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	162
Annotating genomes at increased scale and resolution	154
Adaptation: by giant leaps or many tiny steps?	149
Advancing the applications of liquid biopsies in oncology	149
Genomic landscape of cancer in racially and ethnically diverse populations	141
Intrinsically disordered regions as facilitators of the transcription factor target search	138
Layering epigenomic and transcriptomic space	135
Revealing gene function with statistical inference at single-cell resolution	121
Targeted genome-modification tools and their advanced applications in crop breeding	118
Epigenomes get personal	115
Predicting the effects of multigene perturbations	113
The hidden diversity of tumours	110
Mate choice through a genomic lens	109
Swapping genes within and beyond our bodies	109
Miller spreads and the power of observation	108
Single cell–cell communication	105
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	104
CHIPping away at the genetic aetiology of clonal haematopoiesis	98
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	96
Cohesin and CTCF emerge as building blocks of 3D genome structure	96
The origin and evolution of Wnt signalling	94
Redefining cellular reprogramming with advanced genomic technologies	94
Clinical use of polygenic risk scores: current status, barriers and future directions	93
Genomic newborn screening for rare diseases	92
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	90
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	86
Global genomic diversity for All of Us	85
Social shifts in spiders	83
Fitness effects of mutations throughout evolution	81
High-throughput biochemistry in RNA sequence space: predicting structure and function	81
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	80
Why geneticists should care about male infertility	77
Prime editing: redefining precision genome editing	76
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	76
Recoding genomes with programmed ribosomal frameshifting	71
Targeting and engineering long non-coding RNAs for cancer therapy	68
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	67
Effects of regulatory variants across pig tissues	67
The diversification of methods for studying cell–cell interactions and communication	67
A digital marker for coronary artery disease	65
Microbial genomics for antimicrobial resistance ecology and action	62
A whole-genome shotgun approach to human reference genome sequencing	62

Exon junction complex modulates m6A distribution	60
TimeVault: a synthetic time capsule for transcriptome storage	59
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	59
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	58
Chromosomal instability as a driver of cancer progression	58
Genetics of circadian rhythms and sleep in human health and disease	58
The expanding diagnostic toolbox for rare genetic diseases	55
Sex-specific morphs: the genetics and evolution of intra-sexual variation	54
Mosaic variegated aneuploidy in development, ageing and cancer	54
Genomics for monitoring and understanding species responses to global climate change	53
Divergence and conservation of the meiotic recombination machinery	53
Navigating the pitfalls of mapping DNA and RNA modifications	50
Programmable DNA rearrangements using bridge RNAs	50
Genomic surveillance for antimicrobial resistance — a One Health perspective	50
SCENT defines non-coding disease mechanisms using single-cell multi-omics	48
A developmental exit from totipotency	46
microRNAs as systemic regulators of ageing	45
How ancient genes form animal body plans	44
Harnessing evolution to infer protein networks	44
The evolutionary tale of lactase persistence in humans	44
Challenges and best practices in omics benchmarking	43
Prioritizing the detection of rare pathogenic variants in population screening	43
Tools and tactics for studying alternative splicing	42
Context-specific functions of chromatin remodellers in development and disease	40
New insights into genome folding by loop extrusion from inducible degron technologies	40
Functional synonymous mutations and their evolutionary consequences	40
Translating genomic advances into biodiversity conservation	39
Biobanking with genetics shapes precision medicine and global health	38
Integrating ELSI study teams in paediatric genomic research efforts	37
Packaging and delivery of genome-editing tools	37
Author Correction: Transposable elements: McClintock’s legacy revisited	35
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	35
Nascent transcription quantification with scFLUENT-seq	34
Context-specific regulatory variants in precision medicine and agriculture	34
Multifunctional histone variants in genome function	34
The FinnGen study: disease insights from a ‘bottlenecked’ population	33
The nexus between RNA-binding proteins and their effectors	33
tRNA dysregulation and disease	32
Predicting gene expression from DNA sequence using deep learning models	31
Cell-type deconvolution methods for spatial transcriptomics	30
Towards improved fine-mapping of candidate causal variants	30
Reading cell division histories from the methylome	29
The lives of cells, recorded	29
Methods and applications for single-cell and spatial multi-omics	28
Global cooperation for a global pandemic	28
In vivo editing of blood stem cells	27
Mary Lyon and the birth of X-inactivation research	26
Ancient migration and the modern genome	25
Corrupted USB1 fails to process microRNAs required for blood development	25
The continuum of transcription factor affinities	25
Stem cell-derived organoid models: defying the Hayflick limit	25
The regulatory landscape of chromatin accessibility	23
The genetic basis of human height	22
Monitoring biological effects of somatic cell genome editing	22
De novo genes: from non-genic to genic	22
A codon-resolved view of subcellular translation with LOCL-TL	22
Single-cell genomics meets human genetics	21
Transposable elements as catalysts of evolutionary innovation	18
Computational approaches for multimodal lineage tracing	18
Spatial architecture of development and disease	18
Making sense of the polygenicity of complex traits	17
Biological roles of adenine methylation in RNA	17
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01	17
The gene variant that helped put Latinxs in the 1000 genomes project	17
Author Correction: Forensic genetics in the omics era	16
Tandem repeats in the long-read sequencing era	16
Forensic genetics in the omics era	16
Sequencing-based analysis of microbiomes	16
Endogenous retroviruses: unveiling new targets for cancer immunotherapy	16
Genetic variation across and within individuals	16
Single-cell trimodal profiling with scHiCAR	15
Cytoplasmic mRNA decay and quality control machineries in eukaryotes	15
BANKSY: scalable cell typing and domain segmentation for spatial omics	15
Prime editing for precise and highly versatile genome manipulation	15
Plant pattern recognition receptors: from evolutionary insight to engineering	15
Tracking protein binding to cis-regulatory elements with PRINT	14
Current advances in primate genomics: novel approaches for understanding evolution and disease	14
Ancestral diversity in complex disease genetics: from discovery to translation	14
Determining variant effects with pooled prime editing	13
Cryptic initiation drives transcriptional junk in ageing	13

How the waxing and waning of a mutation determines HIV treatment success	13
From clonality to complexity: a journey through microbial ecology and evolution	13
Methods and applications of genome-wide profiling of DNA damage and rare mutations	12
Live long & prosper: evidence of evolutionary forces on lifespan	12
Nuclear genome influences mitochondrial DNA	12
Genome-wide association testing beyond SNPs	11
Dissecting pleiotropy to gain mechanistic insights into human disease	11
Mechanisms of DNA specificity in chromatin remodelling	9
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	9
Prompt-based bioinformatics: a new interface for multi-omics analysis	9
Measuring the effects of regulatory variants in an endogenous context	8
High-resolution imaging of RNA and proteins in thick tissues using cycleHCR	8
Plant pangenomes for crop improvement, biodiversity and evolution	8
Efficient computation reveals rare CRISPR–Cas systems	7
Deafness: from genetic architecture to gene therapy	7
Spatial miRNomics: towards the integration of microRNAs in spatial biology	7
Tandem repeat variation of human centromeres	7
Prospects for personalized cancer treatment in the era of single-cell sequencing	7
How classical genetics uncovered key determinants of TE silencing	7
Genetics of glycosylation in mammalian development and disease	7
From models to molecules: self-organized and instructed modes of developmental patterning	6
Chromatin loops facilitate co-regulation of paralogues	6
Genetic influences on haematopoiesis	6
An uneasy truce between population health and the gene pools within our bodies	6
Harnessing lateral gene transfer and endosymbiosis for adaptation	6
The genetic foundations of convergent traits	5
Exploring biodiversity through museomics	5
Methodological opportunities in genomic data analysis to advance health equity	5
Publisher Correction: How germ granules promote germ cell fate	5
The long reach of the Red Queen	5
Connecting noncoding variants to human traits	5
The regulation and function of post-transcriptional RNA splicing	5
Dynamic alternative DNA structures in biology and disease	5
Gene regulatory network inference in the era of single-cell multi-omics	5
Single-cell omics meets organoid cultures	5
The design and engineering of synthetic genomes	5
RNA barcoding: the catalyst for the single-cell revolution	5
Harnessing artificial intelligence to advance CRISPR-based genome editing technologies	5
Viral protection from viruses	5
An evolutionary continuum between non-coding and coding DNA	5
Pharmacogenomics: current status and future perspectives	5
Alu sequences promote long-distance relationships	5
When cellular reprogramming meets AI: towards de novo cell design	4
Author Correction: Evolution and regulation of animal sex chromosomes	4
Emergence and evolution of protein-coding de novo genes	4
Charting the world’s microbiomes	4
Identifying off-target effects of genome editing with Tracking-seq	4
Not all co-repressors are equal	4
To the rescue by blocking cryptic splicing	4
Context-specific Polycomb mechanisms in development	4
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	4
Engineering an oscillating gene circuit to delay cellular ageing	4
Selection on structural variation in the amylase locus	4
Systemic cell–cell communication in cancer	4
More than meets the eye(spot): evolution through co-option of developmental programmes	4
Genetics of human telomere biology disorders	4
Understanding human placentation through spatial multiomics	4
Metabolic engineering of plant medicines	3
Unlocking the potential of pedigree genomics via precision governance	3
The evolution of Mycobacterium tuberculosis as humans migrated out of Africa	3
A crossroads in the timeline of human evolution	3
Revealing secrets of human genetic variation with population databases	3
Collaborating at the nexus of genomics, humanities, social science and stakeholders	3
A call to action to scale up research and clinical genomic data sharing	3
CROWN-seq reveals m6Am landscapes and transcription start site diversity	3
Adapting systems biology to address the complexity of human disease in the single-cell era	3
Tracing the evolution of sequencing into the era of genomic medicine	3
Regulatory genomics at biobank scales	3
Nuclear receptors — studying genes to understand hormones	3
A TAD refined for gene regulation	3
RNA splicing — a central layer of gene regulation	3
Variant calling and benchmarking in an era of complete human genome sequences	3
SIMPLE-seq to decode DNA methylation dynamics in single cells	3
Predictive evidence of the relevance of epigenetics to PTSD	3
DNA Typewriter	3
Genome-scale models in human metabologenomics	2
Genetic prediction of multi-omic traits	2
Locking in a synthetic genetic code	2
Mapping trait-associated cells with spatial transcriptomics	2
Mapping vertebrate brain evolution	2
Ethical governance for genomic data science in the cloud	2
Spatial epigenomics in single cells	2
Measuring biological age using omics data	2
Illuminating the human yolk sac through single-cell omics	2
Thoughts on a legacy	2
Regulatory genome annotation	2
From Mendel’s laws to non-Mendelian inheritance	2
Gene therapy for deafness: we can do more	2
From genome to drug: the hidden story of diversity	2
Sequencing and characterizing short tandem repeats in the human genome	2
Target-directed microRNA degradation in Drosophila	2
Non-coding RNAs in disease: from mechanisms to therapeutics	2
High-throughput identification of aptamer–target pairs with SPARK-seq	2
Interpretation, extrapolation and perturbation of single cells	2
Whole-genome spatial transcriptomic imaging with RAEFISH	2