Nature Reviews Genetics

Article	Citations
The different faces of transcription factor sensitivity	1489
Explaining the male bias in cancers	932
Single-cell expression profiling has its roots in in situ techniques	928
Tightening the (neural) net for protein structure prediction	927
Enhancing sustainable development through plant genetics	828
SCOPE-ing out eukaryotic 6mA	735
Weaponized genomics: potential threats to international and human security	721
The evolution of modifier genes	638
Getting organized with non-coding RNAs	517
Imprinted genes and the manipulation of parenting in mammals	464
The evolution of DNA sequencing with microfluidics	420
Harnessing deep learning for population genetic inference	398
Interrogating epigenetic mechanisms with chemically customized chromatin	382
Disentangling population structure in marine species	360
Means, mechanisms and consequences of adenine methylation in DNA	309
Pleiotropy, epistasis and the genetic architecture of quantitative traits	297
Genomic insights into conifer evolution	247
Unveiling the expanding protein universe of life	246
Rapid pathogen surveillance: field-ready sequencing solutions	238
The evolutionary foundations of transcriptional regulation in animals	228
The origin of animals and fungi	207
Changes in cell-cycle rate drive diverging cell fates	203
RNA polymerase II transcription compartments — from factories to condensates	200
Progress in toxicogenomics to protect human health	195
More than a decade of genetic research on the Denisovans	188

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	185
Testing the super-enhancer concept	182
Abiotic stress responses in plants	182
Best practices for single-cell analysis across modalities	169
Genomic landscape of cancer in racially and ethnically diverse populations	168
Mapping dosage	163
Mini-colons unlock tumour development outside the body	162
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	162
Revealing gene function with statistical inference at single-cell resolution	157
Layering epigenomic and transcriptomic space	155
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	152
Non-retroviral RNA viruses in eukaryotic genomes	148
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	142
CRISPR editing within microbial communities	141
Targeted genome-modification tools and their advanced applications in crop breeding	135
Predicting the effects of multigene perturbations	131
Intrinsically disordered regions as facilitators of the transcription factor target search	131
Epigenomes get personal	130
The hidden diversity of tumours	128
CHIPping away at the genetic aetiology of clonal haematopoiesis	126
Swapping genes within and beyond our bodies	124
Miller spreads and the power of observation	124
Mate choice through a genomic lens	120
Fine-mapping causal variants — why finding ‘the one’ can be futile	116
Single cell–cell communication	112
Cohesin and CTCF emerge as building blocks of 3D genome structure	110
Retrotransposons: still mobile in humans	110
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	109
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	108
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	102
Genomic newborn screening for rare diseases	96
The origin and evolution of Wnt signalling	94
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	93
Social shifts in spiders	91
The final pieces of the human genome	89
Fitness effects of mutations throughout evolution	88
Global genomic diversity for All of Us	88
The diversification of methods for studying cell–cell interactions and communication	87
High-throughput biochemistry in RNA sequence space: predicting structure and function	87
The potential of mitochondrial genome engineering	86
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	86
Why geneticists should care about male infertility	82
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	80
Effects of regulatory variants across pig tissues	80
Targeting and engineering long non-coding RNAs for cancer therapy	80
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	78
A digital marker for coronary artery disease	77
Exon junction complex modulates m6A distribution	77
A whole-genome shotgun approach to human reference genome sequencing	75
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	74

Genomic data sharing: you don’t know what you’ve got (till it’s gone)	71
Mosaic variegated aneuploidy in development, ageing and cancer	70
Navigating the pitfalls of mapping DNA and RNA modifications	69
Divergence and conservation of the meiotic recombination machinery	66
Chromosomal instability as a driver of cancer progression	65
Sex-specific morphs: the genetics and evolution of intra-sexual variation	64
Genomic surveillance for antimicrobial resistance — a One Health perspective	61
Genetics of circadian rhythms and sleep in human health and disease	60
The expanding diagnostic toolbox for rare genetic diseases	59
Genomics for monitoring and understanding species responses to global climate change	59
Laterally mobile chromosomes	58
Using cell-free DNA to infer gene expression	56
Programmable DNA rearrangements using bridge RNAs	55
SCENT defines non-coding disease mechanisms using single-cell multi-omics	53
A developmental exit from totipotency	50
The evolutionary tale of lactase persistence in humans	50
Biobanking with genetics shapes precision medicine and global health	49
microRNAs as systemic regulators of ageing	47
Functional synonymous mutations and their evolutionary consequences	47
Translating genomic advances into biodiversity conservation	46
How ancient genes form animal body plans	45
Prioritizing the detection of rare pathogenic variants in population screening	45
New insights into genome folding by loop extrusion from inducible degron technologies	45
Context-specific functions of chromatin remodellers in development and disease	44
Challenges and best practices in omics benchmarking	42
Author Correction: Transposable elements: McClintock’s legacy revisited	42
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	40
Global cooperation for a global pandemic	37
Context-specific regulatory variants in precision medicine and agriculture	37
Integrating ELSI study teams in paediatric genomic research efforts	36
Packaging and delivery of genome-editing tools	36
Predicting gene expression from DNA sequence using deep learning models	36
The lives of cells, recorded	35
Cell-type deconvolution methods for spatial transcriptomics	34
Multifunctional histone variants in genome function	34
The FinnGen study: disease insights from a ‘bottlenecked’ population	33
tRNA dysregulation and disease	33
The nexus between RNA-binding proteins and their effectors	33
Towards improved fine-mapping of candidate causal variants	33
Methods and applications for single-cell and spatial multi-omics	32
In vivo editing of blood stem cells	31
Homozygosity mapping: a game-changer for autosomal recessive diseases	30
Publisher Correction: Sociotechnical safeguards for genomic data privacy	29
Corrupted USB1 fails to process microRNAs required for blood development	28
Ancient migration and the modern genome	28
Mary Lyon and the birth of X-inactivation research	28
The regulatory landscape of chromatin accessibility	28
Stem cell-derived organoid models: defying the Hayflick limit	27
The continuum of transcription factor affinities	26
De novo genes: from non-genic to genic	23
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	23
First glimpse of enhancers in gene regulation	22
Single-cell genomics meets human genetics	21
The genetic basis of human height	20
Biological roles of adenine methylation in RNA	20
EpiDamID, a new single-cell multi-omics tool	19
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01	19
Impact of genetic ancestry on viral infection response	18
The gene variant that helped put Latinxs in the 1000 genomes project	18
Endogenous retroviruses: unveiling new targets for cancer immunotherapy	17
Making sense of the polygenicity of complex traits	17
Publisher Correction: The relationship between genome structure and function	17
Cytoplasmic mRNA decay and quality control machineries in eukaryotes	16
Plant pattern recognition receptors: from evolutionary insight to engineering	16
Genetic variation across and within individuals	15
Tandem repeats in the long-read sequencing era	15
Sequencing-based analysis of microbiomes	14
A vast potential genome editor toolbox	14
Interplay between chromatin marks in development and disease	14
The human genetic epidemiology of COVID-19	14
Prime editing for precise and highly versatile genome manipulation	14
Current advances in primate genomics: novel approaches for understanding evolution and disease	12
Tracking haplotypes to quantify genome erosion	12
BANKSY: scalable cell typing and domain segmentation for spatial omics	12
The genetics of obesity: from discovery to biology	11
DNA replication in cell fate reprogramming	11
Tracking protein binding to cis-regulatory elements with PRINT	11
Cryptic initiation drives transcriptional junk in ageing	10
Genome-wide association testing beyond SNPs	10
Nuclear genome influences mitochondrial DNA	10

How the waxing and waning of a mutation determines HIV treatment success	10
Live long & prosper: evidence of evolutionary forces on lifespan	10
Methods and applications of genome-wide profiling of DNA damage and rare mutations	10
Determining variant effects with pooled prime editing	9
Neighbourly modulation of transcript isoforms	9
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	9
Efficient computation reveals rare CRISPR–Cas systems	9
Prompt-based bioinformatics: a new interface for multi-omics analysis	9
Tandem repeat variation of human centromeres	9
Plant pangenomes for crop improvement, biodiversity and evolution	9
High-resolution imaging of RNA and proteins in thick tissues using cycleHCR	8
DNA methylation-based predictors of health: applications and statistical considerations	8
Measuring the effects of regulatory variants in an endogenous context	8
Genetics of glycosylation in mammalian development and disease	8
Prospects for personalized cancer treatment in the era of single-cell sequencing	8
Spatial miRNomics: towards the integration of microRNAs in spatial biology	8
Deafness: from genetic architecture to gene therapy	8
Gregor Mendel and the concepts of dominance and recessiveness	7
Chromatin loops facilitate co-regulation of paralogues	7
Harnessing lateral gene transfer and endosymbiosis for adaptation	7
An uneasy truce between population health and the gene pools within our bodies	7
Gene regulatory network inference in the era of single-cell multi-omics	6
Exploring biodiversity through museomics	6
Dynamic alternative DNA structures in biology and disease	6
Transcriptional coupling of long-distance genes	5
Publisher Correction: How germ granules promote germ cell fate	5
RNA barcoding: the catalyst for the single-cell revolution	5
Methodological opportunities in genomic data analysis to advance health equity	5
Single-cell omics meets organoid cultures	5
Beyond genetics for cancer evolution	5
Viral protection from viruses	5
The design and engineering of synthetic genomes	5
The regulation and function of post-transcriptional RNA splicing	5
Detecting pregnancy complications from blood	5
Connecting noncoding variants to human traits	5
Foreseeing the principles of genome architecture	5
Pharmacogenomics: current status and future perspectives	4
Navigating the pitfalls of applying machine learning in genomics	4
Author Correction: Evolution and regulation of animal sex chromosomes	4
An evolutionary continuum between non-coding and coding DNA	4
To the rescue by blocking cryptic splicing	4
The biological and clinical significance of emerging SARS-CoV-2 variants	4
Drug delivery systems for RNA therapeutics	4
Systemic cell–cell communication in cancer	4
Alu sequences promote long-distance relationships	4
An evolving hypothesis in autoimmune disease genetics	4
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	4
Charting the world’s microbiomes	3
Sex differences of oestradiol-mediated gene expression	3
Tracing the evolution of sequencing into the era of genomic medicine	3
Revealing secrets of human genetic variation with population databases	3
A crossroads in the timeline of human evolution	3
A call to action to scale up research and clinical genomic data sharing	3
Biomarker benchmarking	3
Selection on structural variation in the amylase locus	3
Identifying off-target effects of genome editing with Tracking-seq	3
Adapting systems biology to address the complexity of human disease in the single-cell era	3
Genetics of human telomere biology disorders	3
Metabolic engineering of plant medicines	3
RNA splicing — a central layer of gene regulation	3
The genetics of human performance	3
Predictive evidence of the relevance of epigenetics to PTSD	3
Variant calling and benchmarking in an era of complete human genome sequences	3
The root cause of shoot-borne roots	3
Understanding human placentation through spatial multiomics	3
Not all co-repressors are equal	3
Context-specific Polycomb mechanisms in development	3
Tuning mutagenesis by functional outcome	3
The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus	3
SIMPLE-seq to decode DNA methylation dynamics in single cells	3
A body-wide view of somatic mutations	3
When cellular reprogramming meets AI: towards de novo cell design	3
CROWN-seq reveals m6Am landscapes and transcription start site diversity	3
A TAD refined for gene regulation	3
Engineering an oscillating gene circuit to delay cellular ageing	3
Towards gene therapy for Tay-Sachs disease	2
The effects of loss of Y chromosome on male health	2
Histone post-translational modifications — cause and consequence of genome function	2
Measuring biological age using omics data	2
Spatial epigenomics in single cells	2
Human organs-on-chips for disease modelling, drug development and personalized medicine	2
Computational methods for analysing multiscale 3D genome organization	2
Maverick — top gun of horizontal gene transfer	2
DNA Typewriter	2
DNA methylation in mammalian development and disease	2
Ethical governance for genomic data science in the cloud	2
From genome to drug: the hidden story of diversity	2
Mapping vertebrate brain evolution	2
Target-directed microRNA degradation in Drosophila	2
Sequencing and characterizing short tandem repeats in the human genome	2
Nuclear receptors — studying genes to understand hormones	2
The complex non-genetic inheritance of complex traits	2
Gene therapy for deafness: we can do more	2
Author Correction: Functional genomics data: privacy risk assessment and technological mitigation	2
Genetic prediction of multi-omic traits	2