Nature Reviews Genetics

Article	Citations
Tightening the (neural) net for protein structure prediction	965
Enhancing sustainable development through plant genetics	950
Single-cell expression profiling has its roots in in situ techniques	778
Explaining the male bias in cancers	749
The different faces of transcription factor sensitivity	671
SCOPE-ing out eukaryotic 6mA	541
The evolution of modifier genes	495
Harnessing deep learning for population genetic inference	437
Weaponized genomics: potential threats to international and human security	413
Interrogating epigenetic mechanisms with chemically customized chromatin	401
Getting organized with non-coding RNAs	373
Disentangling population structure in marine species	325
Imprinted genes and the manipulation of parenting in mammals	308
The evolution of DNA sequencing with microfluidics	263
Means, mechanisms and consequences of adenine methylation in DNA	255
Pleiotropy, epistasis and the genetic architecture of quantitative traits	246
Genomic insights into conifer evolution	234
Unveiling the expanding protein universe of life	210
Rapid pathogen surveillance: field-ready sequencing solutions	209
The origin of animals and fungi	203
Cis-regulatory elements at cellular resolution	197
Changes in cell-cycle rate drive diverging cell fates	197
The evolutionary foundations of transcriptional regulation in animals	191
RNA polymerase II transcription compartments — from factories to condensates	191
Best practices for single-cell analysis across modalities	180

Progress in toxicogenomics to protect human health	173
More than a decade of genetic research on the Denisovans	173
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	169
Non-retroviral RNA viruses in eukaryotic genomes	168
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores	162
Mapping dosage	160
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	160
Layering epigenomic and transcriptomic space	154
Mini-colons unlock tumour development outside the body	152
Genomic landscape of cancer in racially and ethnically diverse populations	151
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	151
CRISPR editing within microbial communities	137
Revealing gene function with statistical inference at single-cell resolution	135
Intrinsically disordered regions as facilitators of the transcription factor target search	132
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	132
Targeted genome-modification tools and their advanced applications in crop breeding	130
Epigenomes get personal	127
Predicting the effects of multigene perturbations	126
CHIPping away at the genetic aetiology of clonal haematopoiesis	121
The hidden diversity of tumours	118
Swapping genes within and beyond our bodies	114
Mate choice through a genomic lens	112
Miller spreads and the power of observation	111
Single cell–cell communication	110
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	108
Cohesin and CTCF emerge as building blocks of 3D genome structure	107
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	103
Fine-mapping causal variants — why finding ‘the one’ can be futile	102
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	99
Retrotransposons: still mobile in humans	97
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	96
Genomic newborn screening for rare diseases	95
The origin and evolution of Wnt signalling	93
Global genomic diversity for All of Us	91
Social shifts in spiders	89
The final pieces of the human genome	88
Fitness effects of mutations throughout evolution	86
The potential of mitochondrial genome engineering	84
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	84
Targeting and engineering long non-coding RNAs for cancer therapy	82
High-throughput biochemistry in RNA sequence space: predicting structure and function	82
Why geneticists should care about male infertility	81
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	79
The diversification of methods for studying cell–cell interactions and communication	77
Effects of regulatory variants across pig tissues	74
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	73
Exon junction complex modulates m6A distribution	71
A digital marker for coronary artery disease	68
A whole-genome shotgun approach to human reference genome sequencing	67
Mosaic variegated aneuploidy in development, ageing and cancer	67

Divergence and conservation of the meiotic recombination machinery	67
Sex-specific morphs: the genetics and evolution of intra-sexual variation	64
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	63
Navigating the pitfalls of mapping DNA and RNA modifications	62
Genetics of circadian rhythms and sleep in human health and disease	61
The expanding diagnostic toolbox for rare genetic diseases	60
Chromosomal instability as a driver of cancer progression	59
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	58
Genomics for monitoring and understanding species responses to global climate change	56
Genomic surveillance for antimicrobial resistance — a One Health perspective	54
Programmable DNA rearrangements using bridge RNAs	52
Using cell-free DNA to infer gene expression	50
SCENT defines non-coding disease mechanisms using single-cell multi-omics	49
Laterally mobile chromosomes	49
A developmental exit from totipotency	48
The evolutionary tale of lactase persistence in humans	48
microRNAs as systemic regulators of ageing	47
Prioritizing the detection of rare pathogenic variants in population screening	47
How ancient genes form animal body plans	46
New insights into genome folding by loop extrusion from inducible degron technologies	44
Functional synonymous mutations and their evolutionary consequences	41
Biobanking with genetics shapes precision medicine and global health	40
Challenges and best practices in omics benchmarking	39
Context-specific functions of chromatin remodellers in development and disease	39
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	38
Translating genomic advances into biodiversity conservation	38
Context-specific regulatory variants in precision medicine and agriculture	37
Author Correction: Transposable elements: McClintock’s legacy revisited	37
Global cooperation for a global pandemic	34
Cell-type deconvolution methods for spatial transcriptomics	33
The FinnGen study: disease insights from a ‘bottlenecked’ population	33
tRNA dysregulation and disease	33
Integrating ELSI study teams in paediatric genomic research efforts	32
Packaging and delivery of genome-editing tools	31
The nexus between RNA-binding proteins and their effectors	30
The lives of cells, recorded	30
Towards improved fine-mapping of candidate causal variants	30
Predicting gene expression from DNA sequence using deep learning models	29
Multifunctional histone variants in genome function	29
Methods and applications for single-cell and spatial multi-omics	28
In vivo editing of blood stem cells	28
Homozygosity mapping: a game-changer for autosomal recessive diseases	25
Publisher Correction: Sociotechnical safeguards for genomic data privacy	24
Corrupted USB1 fails to process microRNAs required for blood development	23
Mary Lyon and the birth of X-inactivation research	23
Stem cell-derived organoid models: defying the Hayflick limit	22
Ancient migration and the modern genome	22
The regulatory landscape of chromatin accessibility	22
The genetic basis of human height	21
First glimpse of enhancers in gene regulation	21
De novo genes: from non-genic to genic	20
The continuum of transcription factor affinities	19
From genotype to phenotype: genetics of mammalian long non-coding RNAs in vivo	19
Spatial architecture of development and disease	18
Biological roles of adenine methylation in RNA	18
EpiDamID, a new single-cell multi-omics tool	18
Single-cell genomics meets human genetics	18
Impact of genetic ancestry on viral infection response	17
Endogenous retroviruses: unveiling new targets for cancer immunotherapy	15
The gene variant that helped put Latinxs in the 1000 genomes project	15
Tandem repeats in the long-read sequencing era	15
Sequencing-based analysis of microbiomes	14
Genetic variation across and within individuals	14
Publisher Correction: The relationship between genome structure and function	14
Asymptomatic SARS-CoV-2 infections linked to HLA-B*15:01	14
Cytoplasmic mRNA decay and quality control machineries in eukaryotes	14
Making sense of the polygenicity of complex traits	14
Interplay between chromatin marks in development and disease	14
Prime editing for precise and highly versatile genome manipulation	13
The human genetic epidemiology of COVID-19	13
Plant pattern recognition receptors: from evolutionary insight to engineering	13
A vast potential genome editor toolbox	12
BANKSY: scalable cell typing and domain segmentation for spatial omics	12
Tracking haplotypes to quantify genome erosion	12
DNA replication in cell fate reprogramming	11
How the waxing and waning of a mutation determines HIV treatment success	11
Tracking protein binding to cis-regulatory elements with PRINT	11
Current advances in primate genomics: novel approaches for understanding evolution and disease	11
Prompt-based bioinformatics: a new interface for multi-omics analysis	11
Nuclear genome influences mitochondrial DNA	10

Determining variant effects with pooled prime editing	10
Cryptic initiation drives transcriptional junk in ageing	10
Live long & prosper: evidence of evolutionary forces on lifespan	9
Spatial miRNomics: towards the integration of microRNAs in spatial biology	9
High-resolution imaging of RNA and proteins in thick tissues using cycleHCR	9
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies	9
Genome-wide association testing beyond SNPs	9
Tandem repeat variation of human centromeres	9
Efficient computation reveals rare CRISPR–Cas systems	9
Methods and applications of genome-wide profiling of DNA damage and rare mutations	9
Plant pangenomes for crop improvement, biodiversity and evolution	9
Neighbourly modulation of transcript isoforms	9
Genetics of glycosylation in mammalian development and disease	8
Prospects for personalized cancer treatment in the era of single-cell sequencing	8
Measuring the effects of regulatory variants in an endogenous context	8
Deafness: from genetic architecture to gene therapy	7
Chromatin loops facilitate co-regulation of paralogues	6
Gregor Mendel and the concepts of dominance and recessiveness	6
The regulation and function of post-transcriptional RNA splicing	6
Exploring biodiversity through museomics	6
DNA methylation-based predictors of health: applications and statistical considerations	6
Harnessing lateral gene transfer and endosymbiosis for adaptation	5
Single-cell omics meets organoid cultures	5
Transcriptional coupling of long-distance genes	5
Gene regulatory network inference in the era of single-cell multi-omics	5
An uneasy truce between population health and the gene pools within our bodies	5
Publisher Correction: How germ granules promote germ cell fate	5
Beyond genetics for cancer evolution	5
Dynamic alternative DNA structures in biology and disease	5
Detecting pregnancy complications from blood	5
Viral protection from viruses	5
Foreseeing the principles of genome architecture	5
An evolving hypothesis in autoimmune disease genetics	4
To the rescue by blocking cryptic splicing	4
RNA barcoding: the catalyst for the single-cell revolution	4
The design and engineering of synthetic genomes	4
Author Correction: Evolution and regulation of animal sex chromosomes	4
Navigating the pitfalls of applying machine learning in genomics	4
Connecting noncoding variants to human traits	4
Methodological opportunities in genomic data analysis to advance health equity	4
Systemic cell–cell communication in cancer	4
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution	4
Pharmacogenomics: current status and future perspectives	4
An evolutionary continuum between non-coding and coding DNA	4
Alu sequences promote long-distance relationships	4
Engineering an oscillating gene circuit to delay cellular ageing	3
Genetics of human telomere biology disorders	3
A TAD refined for gene regulation	3
The root cause of shoot-borne roots	3
A crossroads in the timeline of human evolution	3
The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus	3
CROWN-seq reveals m6Am landscapes and transcription start site diversity	3
When cellular reprogramming meets AI: towards de novo cell design	3
Tuning mutagenesis by functional outcome	3
Sex differences of oestradiol-mediated gene expression	3
Context-specific Polycomb mechanisms in development	3
Charting the world’s microbiomes	3
Variant calling and benchmarking in an era of complete human genome sequences	3
SIMPLE-seq to decode DNA methylation dynamics in single cells	3
Sequencing and characterizing short tandem repeats in the human genome	3
A call to action to scale up research and clinical genomic data sharing	3
Adapting systems biology to address the complexity of human disease in the single-cell era	3
Selection on structural variation in the amylase locus	3
Understanding human placentation through spatial multiomics	3
Not all co-repressors are equal	3
Drug delivery systems for RNA therapeutics	3
RNA splicing — a central layer of gene regulation	3
Metabolic engineering of plant medicines	3
Biomarker benchmarking	3
The effects of loss of Y chromosome on male health	3
Tracing the evolution of sequencing into the era of genomic medicine	3
Identifying off-target effects of genome editing with Tracking-seq	3
DNA Typewriter	2
Predictive evidence of the relevance of epigenetics to PTSD	2
Revealing secrets of human genetic variation with population databases	2
The complex non-genetic inheritance of complex traits	2
Mapping vertebrate brain evolution	2
DNA methylation in mammalian development and disease	2
A clinical milestone for CRISPR in sickle-cell disease	2
Human organs-on-chips for disease modelling, drug development and personalized medicine	2
Fighting fibrosis with transient CAR T cells	2
Is enhancer-driven gene regulation all wrapped up?	2
Sequencing to save the Kākāpō	2
Author Correction: Functional genomics data: privacy risk assessment and technological mitigation	2
Genetic prediction of multi-omic traits	2
Ethical governance for genomic data science in the cloud	2
Maverick — top gun of horizontal gene transfer	2
The evolution of Mycobacterium tuberculosis as humans migrated out of Africa	2
Collaborating at the nexus of genomics, humanities, social science and stakeholders	2
Regulatory genomics at biobank scales	2
Illuminating the human yolk sac through single-cell omics	2
Target-directed microRNA degradation in Drosophila	2
Measuring biological age using omics data	2
Computational methods for analysing multiscale 3D genome organization	2
Including diverse populations enhances the discovery of type 2 diabetes loci	2