OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Single-cell expression profiling has its roots in in situ techniques	1038
Explaining the male bias in cancers	944
The different faces of transcription factor sensitivity	775
The evolution of modifier genes	723
Disentangling population structure in marine species	561
Weaponized genomics: potential threats to international and human security	524
Imprinted genes and the manipulation of parenting in mammals	500
Enhancing sustainable development through plant genetics	419
Interrogating epigenetic mechanisms with chemically customized chromatin	405
Pleiotropy, epistasis and the genetic architecture of quantitative traits	388
Gene regulatory networks: from correlative models to causal explanations	383
Microorganisms as architects of a sustainable future	327
The evolution of DNA sequencing with microfluidics	309
Harnessing deep learning for population genetic inference	292
Unveiling the expanding protein universe of life	288
Rapid pathogen surveillance: field-ready sequencing solutions	284
The origin of animals and fungi	259
The evolutionary foundations of transcriptional regulation in animals	231
Progress in toxicogenomics to protect human health	230
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	228
The unbearable presence of senescent cells in ageing	227
Long non-coding RNAs as orchestrators of dosage compensation	211
Cis-regulatory elements at cellular resolution	207
Changes in cell-cycle rate drive diverging cell fates	201
Best practices for single-cell analysis across modalities	199

RNA polymerase II transcription compartments — from factories to condensates	199
More than a decade of genetic research on the Denisovans	189
Mapping dosage	188
Mini-colons unlock tumour development outside the body	185
Non-retroviral RNA viruses in eukaryotic genomes	182
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	178
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores	173
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	173
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	162
Annotating genomes at increased scale and resolution	154
Adaptation: by giant leaps or many tiny steps?	149
Advancing the applications of liquid biopsies in oncology	149
Genomic landscape of cancer in racially and ethnically diverse populations	141
Intrinsically disordered regions as facilitators of the transcription factor target search	138
Layering epigenomic and transcriptomic space	135
Revealing gene function with statistical inference at single-cell resolution	121
Targeted genome-modification tools and their advanced applications in crop breeding	118
Epigenomes get personal	115
Predicting the effects of multigene perturbations	113
The hidden diversity of tumours	110
Swapping genes within and beyond our bodies	109
Mate choice through a genomic lens	109
Miller spreads and the power of observation	108
Single cell–cell communication	105
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	104
CHIPping away at the genetic aetiology of clonal haematopoiesis	98
Cohesin and CTCF emerge as building blocks of 3D genome structure	96
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	96
The origin and evolution of Wnt signalling	94
Redefining cellular reprogramming with advanced genomic technologies	94
Clinical use of polygenic risk scores: current status, barriers and future directions	93
Genomic newborn screening for rare diseases	92
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	90
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	86
Global genomic diversity for All of Us	85
Social shifts in spiders	83
Fitness effects of mutations throughout evolution	81
High-throughput biochemistry in RNA sequence space: predicting structure and function	81
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	80
Why geneticists should care about male infertility	77
Prime editing: redefining precision genome editing	76
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	76
Recoding genomes with programmed ribosomal frameshifting	71
Targeting and engineering long non-coding RNAs for cancer therapy	68
The diversification of methods for studying cell–cell interactions and communication	67
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	67
Effects of regulatory variants across pig tissues	67
A digital marker for coronary artery disease	65
Microbial genomics for antimicrobial resistance ecology and action	62
A whole-genome shotgun approach to human reference genome sequencing	62

Exon junction complex modulates m6A distribution	60
TimeVault: a synthetic time capsule for transcriptome storage	59
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	59
Genetics of circadian rhythms and sleep in human health and disease	58
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	58
Chromosomal instability as a driver of cancer progression	58
The expanding diagnostic toolbox for rare genetic diseases	55
Sex-specific morphs: the genetics and evolution of intra-sexual variation	54
Mosaic variegated aneuploidy in development, ageing and cancer	54
Divergence and conservation of the meiotic recombination machinery	53
Genomics for monitoring and understanding species responses to global climate change	53
Genomic surveillance for antimicrobial resistance — a One Health perspective	50
Navigating the pitfalls of mapping DNA and RNA modifications	50
Programmable DNA rearrangements using bridge RNAs	50
SCENT defines non-coding disease mechanisms using single-cell multi-omics	48
A developmental exit from totipotency	46
microRNAs as systemic regulators of ageing	45
Harnessing evolution to infer protein networks	44
The evolutionary tale of lactase persistence in humans	44
How ancient genes form animal body plans	44
Challenges and best practices in omics benchmarking	43
Prioritizing the detection of rare pathogenic variants in population screening	43
Tools and tactics for studying alternative splicing	42
Functional synonymous mutations and their evolutionary consequences	40
Context-specific functions of chromatin remodellers in development and disease	40
New insights into genome folding by loop extrusion from inducible degron technologies	40
Translating genomic advances into biodiversity conservation	39
Biobanking with genetics shapes precision medicine and global health	38
Packaging and delivery of genome-editing tools	37
Integrating ELSI study teams in paediatric genomic research efforts	37
Author Correction: Transposable elements: McClintock’s legacy revisited	35
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	35
Multifunctional histone variants in genome function	34
Nascent transcription quantification with scFLUENT-seq	34
Context-specific regulatory variants in precision medicine and agriculture	34
The nexus between RNA-binding proteins and their effectors	33
The FinnGen study: disease insights from a ‘bottlenecked’ population	33
tRNA dysregulation and disease	32
Predicting gene expression from DNA sequence using deep learning models	31
Towards improved fine-mapping of candidate causal variants	30
Cell-type deconvolution methods for spatial transcriptomics	30
The lives of cells, recorded	29
Reading cell division histories from the methylome	29
Methods and applications for single-cell and spatial multi-omics	28
Global cooperation for a global pandemic	28