Nature Reviews Genetics

Papers
(The TQCC of Nature Reviews Genetics is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)
ArticleCitations
The different faces of transcription factor sensitivity1489
Explaining the male bias in cancers932
Single-cell expression profiling has its roots in in situ techniques928
Tightening the (neural) net for protein structure prediction927
Enhancing sustainable development through plant genetics828
SCOPE-ing out eukaryotic 6mA735
Weaponized genomics: potential threats to international and human security721
The evolution of modifier genes638
Getting organized with non-coding RNAs517
Imprinted genes and the manipulation of parenting in mammals464
The evolution of DNA sequencing with microfluidics420
Harnessing deep learning for population genetic inference398
Interrogating epigenetic mechanisms with chemically customized chromatin382
Disentangling population structure in marine species360
Means, mechanisms and consequences of adenine methylation in DNA309
Pleiotropy, epistasis and the genetic architecture of quantitative traits297
Genomic insights into conifer evolution247
Unveiling the expanding protein universe of life246
Rapid pathogen surveillance: field-ready sequencing solutions238
The evolutionary foundations of transcriptional regulation in animals228
The origin of animals and fungi207
Changes in cell-cycle rate drive diverging cell fates203
RNA polymerase II transcription compartments — from factories to condensates200
Progress in toxicogenomics to protect human health195
More than a decade of genetic research on the Denisovans188
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation185
Testing the super-enhancer concept182
Abiotic stress responses in plants182
Best practices for single-cell analysis across modalities169
Genomic landscape of cancer in racially and ethnically diverse populations168
Mapping dosage163
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age162
Mini-colons unlock tumour development outside the body162
Revealing gene function with statistical inference at single-cell resolution157
Layering epigenomic and transcriptomic space155
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH152
Non-retroviral RNA viruses in eukaryotic genomes148
Inhibitors of bacterial immune systems: discovery, mechanisms and applications142
CRISPR editing within microbial communities141
Targeted genome-modification tools and their advanced applications in crop breeding135
Intrinsically disordered regions as facilitators of the transcription factor target search131
Predicting the effects of multigene perturbations131
Epigenomes get personal130
The hidden diversity of tumours128
CHIPping away at the genetic aetiology of clonal haematopoiesis126
Swapping genes within and beyond our bodies124
Miller spreads and the power of observation124
Mate choice through a genomic lens120
Fine-mapping causal variants — why finding ‘the one’ can be futile116
Single cell–cell communication112
Retrotransposons: still mobile in humans110
Cohesin and CTCF emerge as building blocks of 3D genome structure110
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA109
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq108
From computational models of the splicing code to regulatory mechanisms and therapeutic implications102
Genomic newborn screening for rare diseases96
The origin and evolution of Wnt signalling94
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements93
Social shifts in spiders91
The final pieces of the human genome89
Global genomic diversity for All of Us88
Fitness effects of mutations throughout evolution88
The diversification of methods for studying cell–cell interactions and communication87
High-throughput biochemistry in RNA sequence space: predicting structure and function87
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis86
The potential of mitochondrial genome engineering86
Why geneticists should care about male infertility82
Effects of regulatory variants across pig tissues80
Targeting and engineering long non-coding RNAs for cancer therapy80
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants80
Indirect recognition of pathogen virulence proteins to activate plant immune receptors78
A digital marker for coronary artery disease77
Exon junction complex modulates m6A distribution77
A whole-genome shotgun approach to human reference genome sequencing75
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans74
Genomic data sharing: you don’t know what you’ve got (till it’s gone)71
Mosaic variegated aneuploidy in development, ageing and cancer70
Navigating the pitfalls of mapping DNA and RNA modifications69
Divergence and conservation of the meiotic recombination machinery66
Chromosomal instability as a driver of cancer progression65
Sex-specific morphs: the genetics and evolution of intra-sexual variation64
Genomic surveillance for antimicrobial resistance — a One Health perspective61
Genetics of circadian rhythms and sleep in human health and disease60
The expanding diagnostic toolbox for rare genetic diseases59
Genomics for monitoring and understanding species responses to global climate change59
Laterally mobile chromosomes58
Using cell-free DNA to infer gene expression56
Programmable DNA rearrangements using bridge RNAs55
SCENT defines non-coding disease mechanisms using single-cell multi-omics53
A developmental exit from totipotency50
The evolutionary tale of lactase persistence in humans50
Biobanking with genetics shapes precision medicine and global health49
microRNAs as systemic regulators of ageing47
Functional synonymous mutations and their evolutionary consequences47
Translating genomic advances into biodiversity conservation46
How ancient genes form animal body plans45
Prioritizing the detection of rare pathogenic variants in population screening45
New insights into genome folding by loop extrusion from inducible degron technologies45
Context-specific functions of chromatin remodellers in development and disease44
Challenges and best practices in omics benchmarking42
Author Correction: Transposable elements: McClintock’s legacy revisited42
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq40
Global cooperation for a global pandemic37
Context-specific regulatory variants in precision medicine and agriculture37
Packaging and delivery of genome-editing tools36
Predicting gene expression from DNA sequence using deep learning models36
Integrating ELSI study teams in paediatric genomic research efforts36
The lives of cells, recorded35
Multifunctional histone variants in genome function34
Cell-type deconvolution methods for spatial transcriptomics34
tRNA dysregulation and disease33
The nexus between RNA-binding proteins and their effectors33
Towards improved fine-mapping of candidate causal variants33
The FinnGen study: disease insights from a ‘bottlenecked’ population33
Methods and applications for single-cell and spatial multi-omics32
In vivo editing of blood stem cells31
Homozygosity mapping: a game-changer for autosomal recessive diseases30
Publisher Correction: Sociotechnical safeguards for genomic data privacy29
Ancient migration and the modern genome28
Mary Lyon and the birth of X-inactivation research28
The regulatory landscape of chromatin accessibility28
Corrupted USB1 fails to process microRNAs required for blood development28
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