OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 29. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)

Article	Citations
The different faces of transcription factor sensitivity	1382
Explaining the male bias in cancers	916
Single-cell expression profiling has its roots in in situ techniques	869
Tightening the (neural) net for protein structure prediction	853
Disentangling population structure in marine species	765
Enhancing sustainable development through plant genetics	678
SCOPE-ing out eukaryotic 6mA	660
Weaponized genomics: potential threats to international and human security	585
The evolution of modifier genes	448
Getting organized with non-coding RNAs	390
The evolution of DNA sequencing with microfluidics	384
Harnessing deep learning for population genetic inference	370
Means, mechanisms and consequences of adenine methylation in DNA	346
Pleiotropy, epistasis and the genetic architecture of quantitative traits	321
Interrogating epigenetic mechanisms with chemically customized chromatin	284
Imprinted genes and the manipulation of parenting in mammals	277
Genomic insights into conifer evolution	223
Unveiling the expanding protein universe of life	221
Rapid pathogen surveillance: field-ready sequencing solutions	215
The origin of animals and fungi	211
Testing the super-enhancer concept	207
Changes in cell-cycle rate drive diverging cell fates	204
RNA polymerase II transcription compartments — from factories to condensates	198
More than a decade of genetic research on the Denisovans	189
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	182

Progress in toxicogenomics to protect human health	182
Abiotic stress responses in plants	180
Best practices for single-cell analysis across modalities	175
CRISPR editing within microbial communities	159
Shared genetic components of multimorbidity	158
Mapping dosage	157
Aneuploidy in the driving seat	155
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	154
Mini-colons unlock tumour development outside the body	152
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	149
Genomic landscape of cancer in racially and ethnically diverse populations	144
Revealing gene function with statistical inference at single-cell resolution	141
Intrinsically disordered regions as facilitators of the transcription factor target search	139
Layering epigenomic and transcriptomic space	139
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	135
Targeted genome-modification tools and their advanced applications in crop breeding	125
Genetics of substance use disorders in the era of big data	124
Predicting the effects of multigene perturbations	124
Epigenomes get personal	124
The hidden diversity of tumours	123
CHIPping away at the genetic aetiology of clonal haematopoiesis	122
Miller spreads and the power of observation	121
Swapping genes within and beyond our bodies	121
Mate choice through a genomic lens	118
Fine-mapping causal variants — why finding ‘the one’ can be futile	115
Cohesin and CTCF emerge as building blocks of 3D genome structure	110
Retrotransposons: still mobile in humans	104
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	104
Single cell–cell communication	103
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	103
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	101
Genomic newborn screening for rare diseases	100
The origin and evolution of Wnt signalling	98
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	93
Social shifts in spiders	90
The final pieces of the human genome	87
Why geneticists should care about male infertility	86
Global genomic diversity for All of Us	84
Fitness effects of mutations throughout evolution	83
High-throughput biochemistry in RNA sequence space: predicting structure and function	82
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	80
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	79
The diversification of methods for studying cell–cell interactions and communication	79
Targeting and engineering long non-coding RNAs for cancer therapy	78
The potential of mitochondrial genome engineering	78
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	77
Exon junction complex modulates m6A distribution	77
Effects of regulatory variants across pig tissues	77
A digital marker for coronary artery disease	77
A whole-genome shotgun approach to human reference genome sequencing	76

Mosaic variegated aneuploidy in development, ageing and cancer	75
Divergence and conservation of the meiotic recombination machinery	69
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	69
Sex-specific morphs: the genetics and evolution of intra-sexual variation	68
The expanding diagnostic toolbox for rare genetic diseases	67
Navigating the pitfalls of mapping DNA and RNA modifications	67
Chromosomal instability as a driver of cancer progression	66
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	66
Genomics for monitoring and understanding species responses to global climate change	66
Genomic surveillance for antimicrobial resistance — a One Health perspective	63
Genetics of circadian rhythms and sleep in human health and disease	61
Using cell-free DNA to infer gene expression	58
Laterally mobile chromosomes	58
Programmable DNA rearrangements using bridge RNAs	54
How ancient genes form animal body plans	53
SCENT defines non-coding disease mechanisms using single-cell multi-omics	52
A developmental exit from totipotency	51
The evolutionary tale of lactase persistence in humans	51
microRNAs as systemic regulators of ageing	51
Prioritizing the detection of rare pathogenic variants in population screening	47
Functional synonymous mutations and their evolutionary consequences	45
Translating genomic advances into biodiversity conservation	45
Context-specific functions of chromatin remodellers in development and disease	45
New insights into genome folding by loop extrusion from inducible degron technologies	44
Biobanking with genetics shapes precision medicine and global health	42
Challenges and best practices in omics benchmarking	42
Theranostic cells: emerging clinical applications of synthetic biology	40
Author Correction: Transposable elements: McClintock’s legacy revisited	40
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	39
Global cooperation for a global pandemic	36
Context-specific regulatory variants in precision medicine and agriculture	36
The FinnGen study: disease insights from a ‘bottlenecked’ population	35
Integrating ELSI study teams in paediatric genomic research efforts	35
Packaging and delivery of genome-editing tools	34
The lives of cells, recorded	33
Cell-type deconvolution methods for spatial transcriptomics	33
Methods and applications for single-cell and spatial multi-omics	32
Predicting gene expression from DNA sequence using deep learning models	32
The nexus between RNA-binding proteins and their effectors	31
In vivo editing of blood stem cells	30
Multifunctional histone variants in genome function	30
The continuum of transcription factor affinities	30
tRNA dysregulation and disease	30
Homozygosity mapping: a game-changer for autosomal recessive diseases	30
Mary Lyon and the birth of X-inactivation research	29
Publisher Correction: Sociotechnical safeguards for genomic data privacy	29