OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Tightening the (neural) net for protein structure prediction	1098
Single-cell expression profiling has its roots in in situ techniques	1039
Explaining the male bias in cancers	892
The different faces of transcription factor sensitivity	831
SCOPE-ing out eukaryotic 6mA	777
The evolution of modifier genes	637
Weaponized genomics: potential threats to international and human security	596
Disentangling population structure in marine species	488
Enhancing sustainable development through plant genetics	455
The evolution of DNA sequencing with microfluidics	449
Microorganisms as architects of a sustainable future	424
Imprinted genes and the manipulation of parenting in mammals	366
Harnessing deep learning for population genetic inference	340
Interrogating epigenetic mechanisms with chemically customized chromatin	323
Means, mechanisms and consequences of adenine methylation in DNA	313
Pleiotropy, epistasis and the genetic architecture of quantitative traits	271
Genomic insights into conifer evolution	265
Unveiling the expanding protein universe of life	237
Rapid pathogen surveillance: field-ready sequencing solutions	237
The origin of animals and fungi	230
Cis-regulatory elements at cellular resolution	225
Changes in cell-cycle rate drive diverging cell fates	216
Progress in toxicogenomics to protect human health	207
The evolutionary foundations of transcriptional regulation in animals	198
More than a decade of genetic research on the Denisovans	194

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	191
RNA polymerase II transcription compartments — from factories to condensates	190
Best practices for single-cell analysis across modalities	189
Mapping dosage	188
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	187
Mini-colons unlock tumour development outside the body	178
Layering epigenomic and transcriptomic space	174
Harnessing functional annotation to improve the accuracy and transferability of polygenic scores	170
Genomic landscape of cancer in racially and ethnically diverse populations	167
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	167
Non-retroviral RNA viruses in eukaryotic genomes	156
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	149
Intrinsically disordered regions as facilitators of the transcription factor target search	149
Revealing gene function with statistical inference at single-cell resolution	147
Epigenomes get personal	146
Targeted genome-modification tools and their advanced applications in crop breeding	146
Predicting the effects of multigene perturbations	142
The hidden diversity of tumours	139
Swapping genes within and beyond our bodies	135
Mate choice through a genomic lens	133
Miller spreads and the power of observation	132
Single cell–cell communication	131
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	130
Retrotransposons: still mobile in humans	127
Fine-mapping causal variants — why finding ‘the one’ can be futile	122
Cohesin and CTCF emerge as building blocks of 3D genome structure	118
The origin and evolution of Wnt signalling	114
CHIPping away at the genetic aetiology of clonal haematopoiesis	104
Redefining cellular reprogramming with advanced genomic technologies	104
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	103
Clinical use of polygenic risk scores: current status, barriers and future directions	102
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	100
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	99
Genomic newborn screening for rare diseases	98
Global genomic diversity for All of Us	97
Social shifts in spiders	95
The final pieces of the human genome	94
Fitness effects of mutations throughout evolution	93
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	92
High-throughput biochemistry in RNA sequence space: predicting structure and function	90
Why geneticists should care about male infertility	82
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	81
The diversification of methods for studying cell–cell interactions and communication	80
Targeting and engineering long non-coding RNAs for cancer therapy	80
Effects of regulatory variants across pig tissues	78
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	77
A digital marker for coronary artery disease	76
Exon junction complex modulates m6A distribution	76
A whole-genome shotgun approach to human reference genome sequencing	74
Genomic data sharing: you don’t know what you’ve got (till it’s gone)	73

Mosaic variegated aneuploidy in development, ageing and cancer	71
Sex-specific morphs: the genetics and evolution of intra-sexual variation	67
Microbial genomics for antimicrobial resistance ecology and action	64
The expanding diagnostic toolbox for rare genetic diseases	63
Navigating the pitfalls of mapping DNA and RNA modifications	62
Genetics of circadian rhythms and sleep in human health and disease	61
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	61
Genomics for monitoring and understanding species responses to global climate change	57
Genomic surveillance for antimicrobial resistance — a One Health perspective	57
Divergence and conservation of the meiotic recombination machinery	56
Chromosomal instability as a driver of cancer progression	56
Programmable DNA rearrangements using bridge RNAs	55
Using cell-free DNA to infer gene expression	54
SCENT defines non-coding disease mechanisms using single-cell multi-omics	51
The evolutionary tale of lactase persistence in humans	50
A developmental exit from totipotency	48
microRNAs as systemic regulators of ageing	46
How ancient genes form animal body plans	46
Prioritizing the detection of rare pathogenic variants in population screening	45
Harnessing evolution to infer protein networks	45
Functional synonymous mutations and their evolutionary consequences	43
New insights into genome folding by loop extrusion from inducible degron technologies	42
Biobanking with genetics shapes precision medicine and global health	42
Context-specific functions of chromatin remodellers in development and disease	40
Translating genomic advances into biodiversity conservation	39
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	36
Challenges and best practices in omics benchmarking	36
Author Correction: Transposable elements: McClintock’s legacy revisited	36
Global cooperation for a global pandemic	35
Packaging and delivery of genome-editing tools	34
Nascent transcription quantification with scFLUENT-seq	34
Towards improved fine-mapping of candidate causal variants	34
Integrating ELSI study teams in paediatric genomic research efforts	32
The FinnGen study: disease insights from a ‘bottlenecked’ population	32
The lives of cells, recorded	32
Context-specific regulatory variants in precision medicine and agriculture	32
Cell-type deconvolution methods for spatial transcriptomics	31
tRNA dysregulation and disease	29
The nexus between RNA-binding proteins and their effectors	29
Multifunctional histone variants in genome function	29
Methods and applications for single-cell and spatial multi-omics	28
Predicting gene expression from DNA sequence using deep learning models	28
In vivo editing of blood stem cells	27
Publisher Correction: Sociotechnical safeguards for genomic data privacy	26
Corrupted USB1 fails to process microRNAs required for blood development	26
Mary Lyon and the birth of X-inactivation research	26