OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
The different faces of transcription factor sensitivity	1436
Explaining the male bias in cancers	922
Single-cell expression profiling has its roots in in situ techniques	911
Tightening the (neural) net for protein structure prediction	900
Disentangling population structure in marine species	801
Enhancing sustainable development through plant genetics	704
SCOPE-ing out eukaryotic 6mA	694
Weaponized genomics: potential threats to international and human security	615
The evolution of modifier genes	492
Getting organized with non-coding RNAs	426
Imprinted genes and the manipulation of parenting in mammals	406
The evolution of DNA sequencing with microfluidics	385
Harnessing deep learning for population genetic inference	366
Pleiotropy, epistasis and the genetic architecture of quantitative traits	345
Interrogating epigenetic mechanisms with chemically customized chromatin	296
Means, mechanisms and consequences of adenine methylation in DNA	290
Genomic insights into conifer evolution	235
Unveiling the expanding protein universe of life	233
Rapid pathogen surveillance: field-ready sequencing solutions	231
The evolutionary foundations of transcriptional regulation in animals	219
The origin of animals and fungi	217
Changes in cell-cycle rate drive diverging cell fates	203
Progress in toxicogenomics to protect human health	194
RNA polymerase II transcription compartments — from factories to condensates	192
More than a decade of genetic research on the Denisovans	191

Testing the super-enhancer concept	183
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation	181
Best practices for single-cell analysis across modalities	169
Abiotic stress responses in plants	169
CRISPR editing within microbial communities	164
Genomic landscape of cancer in racially and ethnically diverse populations	163
Mapping dosage	163
Aneuploidy in the driving seat	159
Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age	155
Mini-colons unlock tumour development outside the body	154
Revealing gene function with statistical inference at single-cell resolution	148
Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH	146
Layering epigenomic and transcriptomic space	143
Intrinsically disordered regions as facilitators of the transcription factor target search	142
Non-retroviral RNA viruses in eukaryotic genomes	133
Targeted genome-modification tools and their advanced applications in crop breeding	131
Inhibitors of bacterial immune systems: discovery, mechanisms and applications	129
Predicting the effects of multigene perturbations	128
Epigenomes get personal	127
The hidden diversity of tumours	126
CHIPping away at the genetic aetiology of clonal haematopoiesis	125
Miller spreads and the power of observation	124
Swapping genes within and beyond our bodies	121
Mate choice through a genomic lens	120
Fine-mapping causal variants — why finding ‘the one’ can be futile	117
Cohesin and CTCF emerge as building blocks of 3D genome structure	107
Single cell–cell communication	107
Retrotransposons: still mobile in humans	106
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq	106
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements	105
From computational models of the splicing code to regulatory mechanisms and therapeutic implications	103
The origin and evolution of Wnt signalling	102
Genomic newborn screening for rare diseases	101
ADAR1 inhibits ZBP1 activation by endogenous Z-RNA	89
Social shifts in spiders	88
The final pieces of the human genome	88
Global genomic diversity for All of Us	87
Why geneticists should care about male infertility	87
Fitness effects of mutations throughout evolution	86
Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis	85
The potential of mitochondrial genome engineering	84
High-throughput biochemistry in RNA sequence space: predicting structure and function	82
Fitness, growth and transmissibility of SARS-CoV-2 genetic variants	81
Targeting and engineering long non-coding RNAs for cancer therapy	80
Effects of regulatory variants across pig tissues	80
The diversification of methods for studying cell–cell interactions and communication	80
Indirect recognition of pathogen virulence proteins to activate plant immune receptors	77
Exon junction complex modulates m6A distribution	77
A digital marker for coronary artery disease	73
A whole-genome shotgun approach to human reference genome sequencing	71

Genomic data sharing: you don’t know what you’ve got (till it’s gone)	71
Divergence and conservation of the meiotic recombination machinery	70
Sex-specific morphs: the genetics and evolution of intra-sexual variation	70
Genomic surveillance for antimicrobial resistance — a One Health perspective	69
Mosaic variegated aneuploidy in development, ageing and cancer	69
Genomics for monitoring and understanding species responses to global climate change	68
Navigating the pitfalls of mapping DNA and RNA modifications	67
Genetics of circadian rhythms and sleep in human health and disease	66
The expanding diagnostic toolbox for rare genetic diseases	63
Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans	62
Laterally mobile chromosomes	59
Chromosomal instability as a driver of cancer progression	59
Using cell-free DNA to infer gene expression	58
SCENT defines non-coding disease mechanisms using single-cell multi-omics	54
The evolutionary tale of lactase persistence in humans	54
Programmable DNA rearrangements using bridge RNAs	54
microRNAs as systemic regulators of ageing	53
A developmental exit from totipotency	53
Functional synonymous mutations and their evolutionary consequences	51
Challenges and best practices in omics benchmarking	49
Context-specific functions of chromatin remodellers in development and disease	46
New insights into genome folding by loop extrusion from inducible degron technologies	45
Prioritizing the detection of rare pathogenic variants in population screening	44
How ancient genes form animal body plans	44
Biobanking with genetics shapes precision medicine and global health	44
Translating genomic advances into biodiversity conservation	44
Author Correction: Transposable elements: McClintock’s legacy revisited	41
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	39
Context-specific regulatory variants in precision medicine and agriculture	37
Global cooperation for a global pandemic	37
Integrating ELSI study teams in paediatric genomic research efforts	36
The FinnGen study: disease insights from a ‘bottlenecked’ population	35
Packaging and delivery of genome-editing tools	34
Cell-type deconvolution methods for spatial transcriptomics	34
The lives of cells, recorded	34
Predicting gene expression from DNA sequence using deep learning models	34
Methods and applications for single-cell and spatial multi-omics	33
Multifunctional histone variants in genome function	33
In vivo editing of blood stem cells	32
tRNA dysregulation and disease	32
The nexus between RNA-binding proteins and their effectors	32
Homozygosity mapping: a game-changer for autosomal recessive diseases	31
Publisher Correction: Sociotechnical safeguards for genomic data privacy	30
The continuum of transcription factor affinities	30
Corrupted USB1 fails to process microRNAs required for blood development	30
Mary Lyon and the birth of X-inactivation research	30