OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Genetics is 28. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
High-resolution 3D genome characterization	1231
Quantifying the effect of reference genome choice	889
Cell interaction by multiplet sequencing	778
SCOPE-ing out eukaryotic 6mA	734
Decoding cell–cell communication using spatial transcriptomics	696
Sequencing to save the Kākāpō	629
Illuminating the human yolk sac through single-cell omics	579
Sex and age affect circadian gene expression	573
Dissecting the genetics of ovarian ageing	486
microRNAs as systemic regulators of ageing	354
Maverick — top gun of horizontal gene transfer	338
Efficient computation reveals rare CRISPR–Cas systems	330
Fighting fibrosis with transient CAR T cells	301
Spatial miRNomics: towards the integration of microRNAs in spatial biology	298
Diversity and consequences of structural variation in the human genome	295
Laterally mobile chromosomes	270
Towards gene therapy for Tay-Sachs disease	261
CRISPR systems go mini	242
The different faces of transcription factor sensitivity	225
Programmable DNA rearrangements using bridge RNAs	202
Promoting a new view of mitochondrial genome regulation	195
Chromatin loops stack up	191
Neighbourly modulation of transcript isoforms	179
Using cell-free DNA to infer gene expression	179
Getting organized with non-coding RNAs	175

Assigning phenotypes to essential human genes	173
The GLUE that holds omics layers together	169
Base editing takes a shot at disease in non-human primates	165
Explaining the male bias in cancers	160
Context-specific functions of chromatin remodellers in development and disease	157
A developmental exit from totipotency	155
Means, mechanisms and consequences of adenine methylation in DNA	148
Prioritizing the detection of rare pathogenic variants in population screening	143
Disentangling population structure in marine species	138
Weaponized genomics: potential threats to international and human security	134
Enhancing sustainable development through plant genetics	130
Single-cell expression profiling has its roots in in situ techniques	125
Genetic conflict and its resolution between the sexes	125
Challenges and best practices in omics benchmarking	122
Selection on synonymous sites: the unwanted transcript hypothesis	118
The puzzling guppy Y chromosome	117
Genomic prediction of neoantigens: immunogenomics before NGS	117
Widespread occurrence of circular RNA in eukaryotes	116
Tightening the (neural) net for protein structure prediction	114
Imprinted genes and the manipulation of parenting in mammals	113
Reverting to old theories of ageing with new evidence for the role of somatic mutations	112
Regulatory promoter architectures in the hands of thermodynamic modelling	111
The complex non-genetic inheritance of complex traits	110
SCENT defines non-coding disease mechanisms using single-cell multi-omics	108
The evolutionary tale of lactase persistence in humans	106
Including diverse populations enhances the discovery of type 2 diabetes loci	102
The evolution of modifier genes	101
How ancient genes form animal body plans	100
Genetics of glycosylation in mammalian development and disease	98
Pleiotropy, epistasis and the genetic architecture of quantitative traits	97
The evolution of DNA sequencing with microfluidics	95
DNA packaging by molecular motors: from bacteriophage to human chromosomes	94
A deep learning method to map tissue architecture	92
Tandem repeat variation of human centromeres	92
Interrogating epigenetic mechanisms with chemically customized chromatin	91
New insights into genome folding by loop extrusion from inducible degron technologies	91
Deafness: from genetic architecture to gene therapy	91
GETting at single-cell chromatin dynamics	84
Transposable elements: McClintock’s legacy revisited	84
Theranostic cells: emerging clinical applications of synthetic biology	83
Translating genomic advances into biodiversity conservation	83
Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination	80
The therapeutic potential of circular RNAs	77
Making sense of the ageing methylome	75
Harnessing deep learning for population genetic inference	75
Pioneer factors — key regulators of chromatin and gene expression	71
Interpreting non-coding disease-associated human variants using single-cell epigenomics	70
Measuring biological age using omics data	69
Computational methods for analysing multiscale 3D genome organization	69
DNA methylation in mammalian development and disease	69

Autophagy genes in biology and disease	68
DNA methylation-based predictors of health: applications and statistical considerations	68
Biobanking with genetics shapes precision medicine and global health	67
Mining genomes to illuminate the specialized chemistry of life	65
Microbiome epidemiology and association studies in human health	64
Human organs-on-chips for disease modelling, drug development and personalized medicine	64
The FinnGen study: disease insights from a ‘bottlenecked’ population	62
WNT regulator controls stripe patterning	62
Spatial resolution of host–microbiome interactions	58
Convergent evolution of prickles across crops	57
Profiling human-specific VNTR expansions	57
Mapping vertebrate brain evolution	57
Global cooperation for a global pandemic	55
Packaging and delivery of genome-editing tools	55
Detecting ribosomal footprints in single cells	54
A comprehensive view of human RNAs	53
From genome to drug: the hidden story of diversity	52
Spatial mapping of translation in single cells	52
A panoramic view of mouse organogenesis	51
Testing the super-enhancer concept	50
Target-directed microRNA degradation in Drosophila	49
Genomic insights into conifer evolution	47
Chromatin loops facilitate co-regulation of paralogues	47
Genetic prediction of multi-omic traits	47
Pan-cancer atlas of intratumour heterogeneity	45
The origin of animals and fungi	44
Disentangling host–microbiota complexity through hologenomics	43
Opportunities and challenges of macrogenetic studies	42
Temporal modelling using single-cell transcriptomics	40
Mapping the minutiae of the human methylome	39
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq	37
Rethinking nomenclature for interspecies cell fusions	37
Beyond assembly: the increasing flexibility of single-molecule sequencing technology	35
A new era in functional genomics screens	33
tRNA dysregulation and disease	33
Predicting variant pathogenicity with AlphaMissense	33
Epigenome plasticity in plants	32
Publisher Correction: Germline risk of clonal haematopoiesis	31
From LD-based mapping to GWAS	30
Author Correction: Functional genomics data: privacy risk assessment and technological mitigation	30
Towards improved genetic diagnosis of human differences of sex development	29
Changes in cell-cycle rate drive diverging cell fates	28
The magic and meaning of Mendel’s miracle	28
The Neanderthal inside us	28
Causal inference for epigenetic ageing	28
Gregor Mendel and the concepts of dominance and recessiveness	28