Nature Reviews Molecular Cell Biology

Article	Citations
When senescence generates pluripotent stem cells	1728
The translation m(o)TOR that propels regeneration	1666
From trans-splicing discovery and onwards, trypanosomes lead the way	1330
A dynamic culture system that models the intricacy of the mammary gland	1031
Transfection reflections: fit-for-purpose delivery of nucleic acids	1008
DNA-repair-driven cell death compels us to rethink cancer therapies	937
Tightening the epithelium to control signalling	853
Histone H1 deamidation regulates DNA double-strand break repair	770
The secretory pathway gets a molecular framework	764
Mechanisms of substrate processing during ER-associated protein degradation	736
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	716
Modulation of cellular processes by histone and non-histone protein acetylation	710
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	563
Understanding mechanisms of antioxidant action in health and disease	549
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	534
Decoding the Ca2+ signal for salt tolerance	500
N-glycan-dependent protein maturation and quality control in the ER	467
The double life of a transcription factor in the cytoplasm	459
Chemical reprogramming of human blood cells	433
Resilience through selective translation	425
How proteins sense their cellular environment	425
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	415
The advent of confocal laser scanning microscopy in biological research	412
Publisher Correction: Plant hormone regulation of abiotic stress responses	399
The emerging mechanisms and functions of microautophagy	383

New insights into activation and function of the AMPK	374
Mechanism and regulation of kinesin motors	368
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	367
The healing role of gasdermin B in IBD	359
C-degron mimicry confers E3 ligase selectivity	355
Nucleosomes as blueprints of genome architecture	351
Studying lysosomal function and dysfunction using LysoIP	346
Silencing centromeres with age	327
DNA looping regulates transcription	318
Coordination of cardiogenesis in vivo and in vitro	305
CRISPR–Cas applications in agriculture and plant research	302
Telomere function and regulation from mouse models to human ageing and disease	290
Bookmarking pluripotency genes	268
The discovery of oncogene-induced senescence	260
ESCRT-III function in membrane fission and repair	258
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	257
Biology and therapeutic targeting of vascular endothelial growth factor A	254
Mechanisms and roles of podosomes and invadopodia	249
Regulation, functions and transmission of bivalent chromatin during mammalian development	246
Regulation of membrane protein structure and function by their lipid nano-environment	237
Curvature-mediated endocytosis	231
Molecular tools for analysing in vivo senescence	227
A quick guide to (transmembrane) planar cell polarity mouse strains	225
Snoozing APC/C for a sweet cell cycle entry	225
A histone variant that manages abiotic stress in plants	218
Improving chemical reprogramming strategies	217
Migrasomes promote angiogenesis	215
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	213
The prospects and opportunities of protein structure prediction with AI	212
The RNA world ‘hypothesis’	210
Science Twitter — navigating change in science communication	199
Circadian clock communication during homeostasis and ageing	197
Splicing regulation through biomolecular condensates and membraneless organelles	189
Context-dependent TGFβ family signalling in cell fate regulation	188
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	182
Why novel mRNA modifications are so challenging and what we can do about it	181
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	175
FOXO transcription factors as mediators of stress adaptation	175
Transposons: catch them if you can	171
RNA binding — a useful third wheel in transcription	170
Like water on rock, the microenvironment bends stem cell fate	165
Mechanisms and regulation of the Hsp70 chaperone network	162
New tool for MAPping microtubule dynamics	162
Activation of human endogenous retroviruses and its physiological consequences	160
Energy-driven genome regulation by ATP-dependent chromatin remodellers	159
Mechanisms of mitochondrial respiratory adaptation	154
Context-specific regulation and function of mRNA alternative polyadenylation	149
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	145
Does species-specific alternative splicing make us human?	145
Revisiting small RNA movement in plants	144

How ancient RNA survives and what we can learn from it	141
Molecular machineries and pathways of mitochondrial protein transport	138
Regulation and function of insulin and insulin-like growth factor receptor signalling	137
Transcriptional control of energy metabolism by nuclear receptors	136
A guide to cell death pathways	131
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	131
Targeted protein degradation: from mechanisms to clinic	131
Apical–basal polarity and the control of epithelial form and function	128
Myosin VI assists in fork protection	123
The centromere as a tag of self-DNA	123
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	120
Cold-induced longevity through proteasome boosting	114
Decoding ubiquitin signals inside cells	114
New frontiers in quality control: the case of GPI-anchored proteins	113
Redox-driven cell death by disulfidptosis and its therapeutic potential	112
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	112
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	108
The technological landscape and applications of single-cell multi-omics	106
The molecular basis for cellular function of intrinsically disordered protein regions	105
DEI conversations: more than a box-ticking exercise	101
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	101
Fat cells have long-lasting (epigenetic) memory	100
Genome characteristics at the borders	99
Anticancer effects of zotatifin are mediated by RNA structure remodelling	98
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	95
ATP and ROS signal cell extrusion	89
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	85
Mechanisms of microtubule organization in differentiated animal cells	83
Microenvironmental determinants of endothelial cell heterogeneity	83
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	81
Interplay between mechanics and signalling in regulating cell fate	80
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	74
Ethylene — the lifeguard hormone	73
Deep learning shapes single-cell data analysis	73
The role and regulation of integrins in cell migration and invasion	73
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	70
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	68
Unravelling oocyte ultrastructure	68
From shortening telomeres to replicative crisis	65
Profiling the disordered proteome in cells using a chemical tag	61
Transcription factors crossing the cell membrane	61
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	61
Mechanisms and regulation of substrate degradation by the 26S proteasome	60
How green is your science? The race to make laboratories sustainable	59
The hunter becomes the hunted in target-directed microRNA degradation	58
The contribution of databases towards understanding the universe of long non-coding RNAs	58
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	58
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	58
Karyopherin-mediated nucleocytoplasmic transport	55
Cis-regulatory elements that tune transcriptional responses in liver drug metabolism and outcomes	50
Exercise metabolism and adaptation in skeletal muscle	50
Translation feedback control in the brain	50
Cellular role of TETs in early embryos	50
Stem cell sources of colon cancer in mice	49
Author Correction: The role of the haematopoietic stem cell niche in development and ageing	48
Following the electric current	45
Cellular and molecular control of vertebrate somitogenesis	44
The senescence-associated secretory phenotype and its physiological and pathological implications	43
Calcium connects lysosomal damage to stress granule formation	43
The birth of evo-devo	43
SWI/SNF chromatin remodellers persist through mitosis	39
Tissue injury leads to the accumulation of somatic mtDNA mutations	39
The bioethics of synthetic cells	39
Deciphering ADP-ribosylation signalling	38
Mechanisms and regulation of DNA end resection in the maintenance of genome stability	38
The bystander effect of pyroptosis	36
Collective cell migration modes in development, tissue repair and cancer	35
Mediat(or)ing adult stem cells by XIST	34
Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking	33
Harnessing fluorescent probes to unveil dynamic membrane mechanics	30
ncRNA regulation of mitochondrial transcription	30
ERMES — from myths to molecules	29
Voices of the new generation: my unconventional way to stay in academia	29
Proteins that assemble co-translationally lean on their partner for stability	29
Spatiotemporal control over cell–matrix interactions using dynamic micropatterns	27
Microtubules provide a mechanical link for YAP/TAZ signalling	26
Functions and therapeutic applications of pseudouridylation	25
Present and future of synthetic cell development	24
The emergence of MARUbe — a hybrid ADP-ribose–ubiquitin modification	23
Mechanical state transitions in the regulation of tissue form and function	23

Signalling mechanisms and cellular functions of SUMO	22
Local and systemic mechanisms that control the hair follicle stem cell niche	22
Smelling your way to longevity	21
Sorting membrane proteins by size in the Golgi	21
Revealing the hidden coding potential of the human genome	20
Internal-m7G-modified mRNAs quake under stress	20
Lasker Award for AlphaFold	20
Epigenetic discovery by enzyme activity profiling	19
Blebbisomes are one bleb away from a functional cell	18
Regulation of RNA-binding proteins by small biomolecules	17
Let’s talk about (biological) sex	16
Size matters	15
A nuclear morphology-based machine learning algorithm for senescence detection	15
The nuance in DNA and transcription factor interactions	15
Decoding the interactions and functions of non-coding RNA with artificial intelligence	15
The birth of stable introns	13
Translating the midbody for cytokinesis	13
Critical constituents and assembly principles of centriole biogenesis in human cells	12
Enabling RNA-compatible synthetic receptors through RNA editing	12
Mitochondrial ROS drive cell cycle progression	11
Early insights into co-translational assembly of protein complexes	11
Mapping organelle supply chains	10
BCL-2 proteins in senescence: beyond a simple target for senolysis?	10
Mechanisms and regulation of human mitochondrial transcription	10
The discovery of cyclin-dependent kinases	10
Cellular functions of eukaryotic RNA helicases and their links to human diseases	10
5mC: what goes on must come off	10
New imprinting control-like regions	10
The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance	10
Author Correction: Fundamentals of redox regulation in biology	9
Mechanistic insights into gasdermin-mediated pyroptosis	9
Monitoring subcellular protein localization at scale in live cells	9
Genome control by SMC complexes	9
Single-cell lipidomics reveals the organizing principle of cell fate decision	9
Viruses show the way	9
Pioneer factors as master regulators of the epigenome and cell fate	9
Shaping epithelial tissues by stem cell mechanics in development and cancer	8
Towards a unified framework for the function of endoplasmic reticulum exit sites	8
Effects of aneuploidy on cell behaviour and function	8
Publisher Correction: Mechanisms and regulation of the Hsp70 chaperone network	8
Paleoproteomics sheds light on million-year-old fossils	8
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing	8
oskar stands on solid ground for translation	7
Gene regulation in time and space during X-chromosome inactivation	7
The double-edged sword of bivalency	7
Exploring the uncharted landscape of truncated mRNAs	7
A novel photosystem assembly line worker	7
Cell–extracellular matrix mechanotransduction in 3D	7
The role of the haematopoietic stem cell niche in development and ageing	6
Protrusion-derived vesicles: new subtype of EVs?	6
Uncovering mRNA sequences that control translation initiation	6
Returning to the lab after a career break	6
Author Correction: Molecular machineries and pathways of mitochondrial protein transport	6
The lipotype hypothesis	6
Principles and dynamics of spindle assembly checkpoint signalling	5
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation	5
How embryos sort themselves out	5
Probing cytoskeletal remodelling by cutting and marking filaments	5
Modes of Notch signalling in development and disease	5
Key challenges and recommendations for defining organelle membrane contact sites	5
Condensates trail the nucleus	5
Mechanics and functional consequences of nuclear deformations	5
Modelling human brain development and disease with organoids	5
Challenges and opportunities in macromolecular structure determination	5
The memory of viscosity	4
Mechanisms of mechanotransduction and physiological roles of PIEZO channels	4
Illuminating protein microenvironments with rotor-based fluorescent amino acids	4
Turning the replisome around	4
Molecular machineries shaping the mitochondrial inner membrane	4
Regulation and functions of non-m6A mRNA modifications	4
DNA modifications walk a fine line between epigenetics and mutagenesis	4
A catalytic function for mammalian Argonautes	4
Base editing of organellar DNA with programmable deaminases	4
Regulation of and challenges in targeting NAD+ metabolism	4
Senescent cells support limb regeneration	4
A histone code controls positional identity in limb regeneration	4
The prompt to discover senolytics	4
The discovery of simple repeats that cause complex disorders	3
Cell quiescence sends argonaute-2 to transposons	3
Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer	3
Modelling tauopathies	3
Genome doubling — twice the same is not the same	3
Good neighbours transfer nucleotides	3
RNF26 and vimentin orchestrate ER stress recovery	3
The neuronal epigenome is special	3
Distal enhancers loop to proximal enhancers, not to promoters	3
Uncovering the complexity of RNA–protein interactions	3
Control of stem cell renewal and fate by YAP and TAZ	2
Mechanisms of auxin action in plant growth and development	2
Structural variation in COOLAIR lncRNA driven by cold	2
Cytosol-to-nucleus journey of a novel histone PTM	2
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics	2
A guide to membraneless organelles and their various roles in gene regulation	2
First demonstration of miRNA-dependent mRNA decay	2
Dodging mitochondrial mislocalization	2