Nature Reviews Molecular Cell Biology

Article	Citations
When senescence generates pluripotent stem cells	2227
Tightening the epithelium to control signalling	1431
Histone H1 deamidation regulates DNA double-strand break repair	1323
The secretory pathway gets a molecular framework	1311
A dynamic culture system that models the intricacy of the mammary gland	970
Transfection reflections: fit-for-purpose delivery of nucleic acids	959
DNA-repair-driven cell death compels us to rethink cancer therapies	929
Advancing single-cell omics and cell-based therapeutics with quantum computing	844
The translation m(o)TOR that propels regeneration	778
Plucking cellular ribosomes with Ribo-Tweezer	740
Single-cell evidence for PANoptosome complexes	733
Mechanisms of substrate processing during ER-associated protein degradation	713
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	704
Understanding mechanisms of antioxidant action in health and disease	632
Regulation of RNA transcript elongation in metazoans and its relevance to disease	597
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	567
Decoding the Ca2+ signal for salt tolerance	557
The double life of a transcription factor in the cytoplasm	548
Chemical reprogramming of human blood cells	511
Resilience through selective translation	480
Programmed ‘DNA splicing’ removes transposons from genes	442
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	432
How proteins sense their cellular environment	422
PIONEARing how DNA sequence composition tunes TF–nucleosome interactions	402
Engineered nanobodies facilitate cryo-EM studies of small proteins	384

Progress in stem cell-based embryo models and their applications in developmental biology and biomedicine	383
The advent of confocal laser scanning microscopy in biological research	354
Mechanism and regulation of kinesin motors	347
The emerging mechanisms and functions of microautophagy	345
N-glycan-dependent protein maturation and quality control in the ER	340
New insights into activation and function of the AMPK	318
C-degron mimicry confers E3 ligase selectivity	312
The discovery of oncogene-induced senescence	307
Nucleosomes as blueprints of genome architecture	294
Silencing centromeres with age	287
Bookmarking pluripotency genes	271
Studying lysosomal function and dysfunction using LysoIP	269
DNA looping regulates transcription	269
Coordination of cardiogenesis in vivo and in vitro	266
Biology and therapeutic potential of extracellular vesicle targeting and uptake	264
Mechanisms and roles of podosomes and invadopodia	253
Regulation, functions and transmission of bivalent chromatin during mammalian development	249
Biology and therapeutic targeting of vascular endothelial growth factor A	242
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	240
ESCRT-III function in membrane fission and repair	236
Regulation of membrane protein structure and function by their lipid nano-environment	233
Telomere function and regulation from mouse models to human ageing and disease	229
CRISPR–Cas applications in agriculture and plant research	219
A quick guide to (transmembrane) planar cell polarity mouse strains	218
Snoozing APC/C for a sweet cell cycle entry	210
A histone variant that manages abiotic stress in plants	199
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	197
Improving chemical reprogramming strategies	196
Migrasomes promote angiogenesis	196
Circadian clock communication during homeostasis and ageing	184
Molecular tools for analysing in vivo senescence	184
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	184
Programmable delivery of mitochondria to specific cell types	183
Context-dependent TGFβ family signalling in cell fate regulation	178
Splicing regulation through biomolecular condensates and membraneless organelles	177
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	173
Science Twitter — navigating change in science communication	165
FOXO transcription factors as mediators of stress adaptation	162
RNA binding — a useful third wheel in transcription	155
Like water on rock, the microenvironment bends stem cell fate	154
Activation of human endogenous retroviruses and its physiological consequences	148
Subcellular localization as a driver of protein function	146
Mechanisms and regulation of the Hsp70 chaperone network	146
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	145
Energy-driven genome regulation by ATP-dependent chromatin remodellers	145
Organelles stick together through PDZD8-mediated condensate formation	144
How ancient RNA survives and what we can learn from it	139
Does species-specific alternative splicing make us human?	135
Regulation and function of insulin and insulin-like growth factor receptor signalling	134
Molecular machineries and pathways of mitochondrial protein transport	130

Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	129
Targeted protein degradation: from mechanisms to clinic	121
A guide to cell death pathways	118
Myosin VI assists in fork protection	114
Decoding ubiquitin signals inside cells	111
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	111
The centromere as a tag of self-DNA	111
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	109
Cold-induced longevity through proteasome boosting	109
Redox-driven cell death by disulfidptosis and its therapeutic potential	108
A demonstration that multivalent interactions drive condensate formation	108
New frontiers in quality control: the case of GPI-anchored proteins	108
Effortless immortalization of primary mouse fibroblasts	103
COPII meets autophagy at the ER membrane	100
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	100
The molecular basis for cellular function of intrinsically disordered protein regions	99
The technological landscape and applications of single-cell multi-omics	97
Genome characteristics at the borders	95
DEI conversations: more than a box-ticking exercise	95
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	93
Fat cells have long-lasting (epigenetic) memory	89
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	87
Anticancer effects of zotatifin are mediated by RNA structure remodelling	87
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	86
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	85
Microenvironmental determinants of endothelial cell heterogeneity	84
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	84
New developments and applications of human organoids	83
Caveolae mechanics in cellular functions and disease	79
The role and regulation of integrins in cell migration and invasion	76
Exchange dynamics and kinetic control of gene regulation complexes	75
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	74
Profiling the disordered proteome in cells using a chemical tag	73
The contribution of databases towards understanding the universe of long non-coding RNAs	62
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	58
The hunter becomes the hunted in target-directed microRNA degradation	56
Transcription factors crossing the cell membrane	55
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	54
From shortening telomeres to replicative crisis	54
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	53
Mechanisms and regulation of substrate degradation by the 26S proteasome	51
Reply to ‘Single-cell evidence for PANoptosome complexes’	50
Exercise metabolism and adaptation in skeletal muscle	49
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	49
Neural crest gene regulatory networks as drivers of development, diversification and disease	48
Cellular role of TETs in early embryos	47
Translation feedback control in the brain	47
Publisher Correction: Advancing single-cell omics and cell-based therapeutics with quantum computing	46
Cis-regulatory elements that tune transcriptional responses in liver drug metabolism and outcomes	44
Following the electric current	43
Stem cell sources of colon cancer in mice	41
Author Correction: The role of the haematopoietic stem cell niche in development and ageing	41
Cellular and molecular control of vertebrate somitogenesis	41
Overcoming cytoskeleton instability in the early embryo	40
Organization of replicated chromosomes by DNA loops and sister chromatid cohesion	40
The senescence-associated secretory phenotype and its physiological and pathological implications	38
SWI/SNF chromatin remodellers persist through mitosis	37
Deciphering ADP-ribosylation signalling	36
Nuclear speckles of GC richness	36
The bystander effect of pyroptosis	33
Calcium connects lysosomal damage to stress granule formation	33
Tissue injury leads to the accumulation of somatic mtDNA mutations	32
The bioethics of synthetic cells	32
The birth of evo-devo	29
Mechanisms and regulation of DNA end resection in the maintenance of genome stability	28
Collective cell migration modes in development, tissue repair and cancer	28
Voices of the new generation: my unconventional way to stay in academia	26
Microtubules provide a mechanical link for YAP/TAZ signalling	24
Harnessing fluorescent probes to unveil dynamic membrane mechanics	23
The emergence of MARUbe — a hybrid ADP-ribose–ubiquitin modification	23
Spatiotemporal control over cell–matrix interactions using dynamic micropatterns	23
Proteins that assemble co-translationally lean on their partner for stability	22
Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking	22
Phase separation across membranes and condensates in cell organization and function	20
ERMES — from myths to molecules	20
Local and systemic mechanisms that control the hair follicle stem cell niche	18
The mechanistic basis and cellular functions of UFMylation	18
Functions and therapeutic applications of pseudouridylation	17
Lasker Award for AlphaFold	16
Present and future of synthetic cell development	16

Smelling your way to longevity	16
Mechanical state transitions in the regulation of tissue form and function	16
Sorting membrane proteins by size in the Golgi	16
Internal-m7G-modified mRNAs quake under stress	15
Regulation of RNA-binding proteins by small biomolecules	14
Epigenetic discovery by enzyme activity profiling	14
Blebbisomes are one bleb away from a functional cell	13
A nuclear morphology-based machine learning algorithm for senescence detection	13
Decoding the interactions and functions of non-coding RNA with artificial intelligence	13
At high noon, plants apply a condensate sunscreen	13
Revealing the hidden coding potential of the human genome	13
Translating the midbody for cytokinesis	12
The birth of stable introns	12
Critical constituents and assembly principles of centriole biogenesis in human cells	12
Early insights into co-translational assembly of protein complexes	12
Cellular functions of eukaryotic RNA helicases and their links to human diseases	12
Enabling RNA-compatible synthetic receptors through RNA editing	12
The nuance in DNA and transcription factor interactions	11
The discovery of cyclin-dependent kinases	11
The emerging importance of UBA6 in ubiquitylation and proteostasis	11
BCL-2 proteins in senescence: beyond a simple target for senolysis?	11
Prevailing views of cell senescence overlook its biological complexity	10
Mechanisms and regulation of human mitochondrial transcription	10
Genome control by SMC complexes	10
Mechanistic insights into gasdermin-mediated pyroptosis	9
The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance	9
Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target	9
Publisher Correction: Mechanisms and regulation of the Hsp70 chaperone network	8
Monitoring subcellular protein localization at scale in live cells	8
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing	8
Single-cell lipidomics reveals the organizing principle of cell fate decision	8
Viruses show the way	8
Bringing CRISPR screens into tissue space	7
Cell–extracellular matrix mechanotransduction in 3D	7
Author Correction: Fundamentals of redox regulation in biology	7
Paleoproteomics sheds light on million-year-old fossils	7
Exploring the uncharted landscape of truncated mRNAs	7
Towards a unified framework for the function of endoplasmic reticulum exit sites	7
A novel photosystem assembly line worker	7
Shaping epithelial tissues by stem cell mechanics in development and cancer	7
Protrusion-derived vesicles: new subtype of EVs?	6
Key challenges and recommendations for defining organelle membrane contact sites	6
The double-edged sword of bivalency	6
Ancient enzymes, new biotechnology applications	6
Principles and dynamics of spindle assembly checkpoint signalling	6
Uncovering mRNA sequences that control translation initiation	6
Author Correction: Molecular machineries and pathways of mitochondrial protein transport	6
The lipotype hypothesis	6
Heterogeneity, dynamics and organelle interactions of lipid droplets	5
The regulation, function and disease relevance of cytoplasmic tRNAs	5
Inflammageing and clonal haematopoiesis interplay and their impact on human disease	5
Illuminating protein microenvironments with rotor-based fluorescent amino acids	5
Tight junction structure, assembly and (dys)function	5
Turning the replisome around	5
A catalytic function for mammalian Argonautes	5
A histone code controls positional identity in limb regeneration	5
DNA modifications walk a fine line between epigenetics and mutagenesis	5
The role of the haematopoietic stem cell niche in development and ageing	5
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation	5
Probing cytoskeletal remodelling by cutting and marking filaments	5
The prompt to discover senolytics	5
How embryos sort themselves out	5
Modes of Notch signalling in development and disease	5
Modelling human brain development and disease with organoids	5
Base editing of organellar DNA with programmable deaminases	4
Regulation and functions of non-m6A mRNA modifications	4
The discovery of simple repeats that cause complex disorders	4
The memory of viscosity	4
Molecular machineries shaping the mitochondrial inner membrane	4
Challenges and opportunities in macromolecular structure determination	4
Genome doubling — twice the same is not the same	4
Condensates trail the nucleus	4
Mechanisms of mechanotransduction and physiological roles of PIEZO channels	4
Senescent cells support limb regeneration	4
Regulation of and challenges in targeting NAD+ metabolism	4
Fatty acid signalling promotes hair regrowth	3
Good neighbours transfer nucleotides	3
Cell quiescence sends argonaute-2 to transposons	3
White adipocyte dysfunction and obesity-associated pathologies in humans	3
Plant microRNA maturation and function	3
The neuronal epigenome is special	3
SLAM passes the haematopoietic stem cell identity test	3
Distal enhancers loop to proximal enhancers, not to promoters	3
Mechanisms and functions of protein S-acylation	3
Uncovering the complexity of RNA–protein interactions	3
A lunapark for secretory mRNA translation at ER junctions	3
Modelling tauopathies	3
The multiple links between actin and mitochondria	3
The cell biology of ferroptosis	3
Biochemical and mechanical regulation of actin dynamics	3
RNF26 and vimentin orchestrate ER stress recovery	3