Nature Reviews Molecular Cell Biology

Article	Citations
The translation m(o)TOR that propels regeneration	2342
When senescence generates pluripotent stem cells	1281
Tightening the epithelium to control signalling	1255
Transfection reflections: fit-for-purpose delivery of nucleic acids	1249
A dynamic culture system that models the intricacy of the mammary gland	1056
From trans-splicing discovery and onwards, trypanosomes lead the way	986
Re-sizing of nuclear pores	776
Histone H1 deamidation regulates DNA double-strand break repair	774
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	754
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	599
Mechanisms of substrate processing during ER-associated protein degradation	594
The aetiology and molecular landscape of insulin resistance	549
Understanding mechanisms of antioxidant action in health and disease	528
Modulation of cellular processes by histone and non-histone protein acetylation	518
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	490
Publisher Correction: Plant hormone regulation of abiotic stress responses	433
Resilience through selective translation	421
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	398
How proteins sense their cellular environment	398
N-glycan-dependent protein maturation and quality control in the ER	387
Decoding the Ca2+ signal for salt tolerance	375
Mechanism and regulation of kinesin motors	372
The emerging mechanisms and functions of microautophagy	356
New insights into activation and function of the AMPK	342
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	341

The healing role of gasdermin B in IBD	338
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	333
CRISPR–Cas applications in agriculture and plant research	332
C-degron mimicry confers E3 ligase selectivity	331
Silencing centromeres with age	318
Bookmarking pluripotency genes	318
Voices of the new generation: open science is good for science (and for you)	304
The discovery of oncogene-induced senescence	299
Regulation, functions and transmission of bivalent chromatin during mammalian development	298
Telomere function and regulation from mouse models to human ageing and disease	294
Nucleosomes as blueprints of genome architecture	291
Biology and therapeutic targeting of vascular endothelial growth factor A	289
Studying lysosomal function and dysfunction using LysoIP	284
Mechanisms and roles of podosomes and invadopodia	276
Regulation of membrane protein structure and function by their lipid nano-environment	275
Curvature-mediated endocytosis	274
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design	274
Big cells, small potential	268
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	249
Molecular tools for analysing in vivo senescence	245
A quick guide to (transmembrane) planar cell polarity mouse strains	236
Science Twitter — navigating change in science communication	233
Migrasomes promote angiogenesis	225
Improving chemical reprogramming strategies	207
The prospects and opportunities of protein structure prediction with AI	205
Why novel mRNA modifications are so challenging and what we can do about it	205
The RNA world ‘hypothesis’	203
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	200
Context-dependent TGFβ family signalling in cell fate regulation	197
Splicing regulation through biomolecular condensates and membraneless organelles	195
Circadian clock communication during homeostasis and ageing	194
Molecular mechanisms and consequences of mitochondrial permeability transition	193
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	193
FOXO transcription factors as mediators of stress adaptation	192
Machinery, regulation and pathophysiological implications of autophagosome maturation	183
Transposons: catch them if you can	176
RNA binding — a useful third wheel in transcription	168
New tool for MAPping microtubule dynamics	167
Energy-driven genome regulation by ATP-dependent chromatin remodellers	166
Activation of human endogenous retroviruses and its physiological consequences	161
Mechanisms of mitochondrial respiratory adaptation	158
Context-specific regulation and function of mRNA alternative polyadenylation	158
Does species-specific alternative splicing make us human?	157
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	153
Regulation and function of insulin and insulin-like growth factor receptor signalling	147
Apical–basal polarity and the control of epithelial form and function	144
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	141
How ancient RNA survives and what we can learn from it	139
Targeted protein degradation: from mechanisms to clinic	138
Transcriptional control of energy metabolism by nuclear receptors	135

Revisiting small RNA movement in plants	133
A guide to cell death pathways	129
Cold-induced longevity through proteasome boosting	127
Myosin VI assists in fork protection	127
New frontiers in quality control: the case of GPI-anchored proteins	126
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	125
The centromere as a tag of self-DNA	125
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	124
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	121
The molecular basis for cellular function of intrinsically disordered protein regions	120
The technological landscape and applications of single-cell multi-omics	116
DEI conversations: more than a box-ticking exercise	115
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	114
Fat cells have long-lasting (epigenetic) memory	110
Genome characteristics at the borders	105
ATP and ROS signal cell extrusion	102
Anticancer effects of zotatifin are mediated by RNA structure remodelling	101
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	97
Microenvironmental determinants of endothelial cell heterogeneity	92
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	89
Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition	89
Deep learning shapes single-cell data analysis	88
Nuclear compartmentalization as a mechanism of quantitative control of gene expression	88
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	87
Interplay between mechanics and signalling in regulating cell fate	86
The role and regulation of integrins in cell migration and invasion	82
Ethylene — the lifeguard hormone	80
Mechanisms of microtubule organization in differentiated animal cells	80
Sleep tight thanks to Parp1	80
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	80
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	79
Unravelling oocyte ultrastructure	76
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	75
From shortening telomeres to replicative crisis	73
The contribution of databases towards understanding the universe of long non-coding RNAs	71
Transcription factors crossing the cell membrane	70
Profiling the disordered proteome in cells using a chemical tag	69
The many regulators of epithelial−mesenchymal transition	66
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	65
How green is your science? The race to make laboratories sustainable	65
The molecular principles of gene regulation by Polycomb repressive complexes	65
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	64
Karyopherin-mediated nucleocytoplasmic transport	62
Exercise metabolism and adaptation in skeletal muscle	60
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	59
Mechanisms of SARS-CoV-2 entry into cells	57
Mechanisms and regulation of substrate degradation by the 26S proteasome	57
EV signalling in the haematopoietic niche	56
Cellular role of TETs in early embryos	55
Translation feedback control in the brain	54
Author Correction: The role of the haematopoietic stem cell niche in development and ageing	52
Cellular and molecular control of vertebrate somitogenesis	51
Following the electric current	51
The senescence-associated secretory phenotype and its physiological and pathological implications	51
The birth of evo-devo	50
Deciphering ADP-ribosylation signalling	44
SWI/SNF chromatin remodellers persist through mitosis	44
Calcium connects lysosomal damage to stress granule formation	42
Mechanisms and regulation of DNA end resection in the maintenance of genome stability	41
The bystander effect of pyroptosis	41
The bioethics of synthetic cells	40
Collective migration modes in development, tissue repair and cancer	36
Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking	33
Mediat(or)ing adult stem cells by XIST	33
Keeping oocytes young	33
Voices of the new generation: my unconventional way to stay in academia	33
Harnessing fluorescent probes to unveil dynamic membrane mechanics	32
ERMES — from myths to molecules	31
Functions and therapeutic applications of pseudouridylation	29
ncRNA regulation of mitochondrial transcription	29
Spatiotemporal control over cell–matrix interactions using dynamic micropatterns	27
Mechanical state transitions in the regulation of tissue form and function	27
Present and future of synthetic cell development	27
Proteins that assemble co-translationally lean on their partner for stability	26
Signalling mechanisms and cellular functions of SUMO	25
Internal-m7G-modified mRNAs quake under stress	24
Local and systemic mechanisms that control the hair follicle stem cell niche	24
Author Correction: Molecular mechanisms underlying nucleotide repeat expansion disorders	24
Sorting membrane proteins by size in the Golgi	23
Smelling your way to longevity	23

Lasker Award for AlphaFold	22
Epigenetic discovery by enzyme activity profiling	22
Let’s talk about (biological) sex	21
Decoding the interactions and functions of non-coding RNA with artificial intelligence	21
Blebbisomes are one bleb away from a functional cell	21
The nuance in DNA and transcription factor interactions	20
A nuclear morphology-based machine learning algorithm for senescence detection	20
Cracking genetic codes of longevity	19
Early insights into co-translational assembly of protein complexes	18
The birth of stable introns	17
Size matters	17
Translating the midbody for cytokinesis	17
Enabling RNA-compatible synthetic receptors through RNA editing	16
Cellular functions of the protein kinase ATM and their relevance to human disease	16
Control of satellite cell function in muscle regeneration and its disruption in ageing	15
Translational control of stem cell function	15
Cellular functions of eukaryotic RNA helicases and their links to human diseases	14
Mapping organelle supply chains	13
The discovery of cyclin-dependent kinases	13
Mitochondrial ROS drive cell cycle progression	13
BCL-2 proteins in senescence: beyond a simple target for senolysis?	12
5mC: what goes on must come off	12
New imprinting control-like regions	12
Mechanistic insights into gasdermin-mediated pyroptosis	11
Genome control by SMC complexes	10
Mechanisms and regulation of human mitochondrial transcription	10
Viruses show the way	10
Pioneer factors as master regulators of the epigenome and cell fate	10
Author Correction: Fundamentals of redox regulation in biology	9
Gene regulation in time and space during X-chromosome inactivation	9
Single-cell lipidomics reveals the organizing principle of cell fate decision	9
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing	8
Effects of aneuploidy on cell behaviour and function	8
Shaping epithelial tissues by stem cell mechanics in development and cancer	8
The role of ordered cooperative assembly in biomolecular condensates	8
Paleoproteomics sheds light on million-year-old fossils	8
Monitoring subcellular protein localization at scale in live cells	8
The role of the haematopoietic stem cell niche in development and ageing	7
A novel photosystem assembly line worker	7
Cell–extracellular matrix mechanotransduction in 3D	7
Returning to the lab after a career break	7
oskar stands on solid ground for translation	7
Uncovering mRNA sequences that control translation initiation	7
The double-edged sword of bivalency	7
Exploring the uncharted landscape of truncated mRNAs	7
Key challenges and recommendations for defining organelle membrane contact sites	6
Mechanics and functional consequences of nuclear deformations	6
Modelling human brain development and disease with organoids	6
Protrusion-derived vesicles: new subtype of EVs?	6
Modes of Notch signalling in development and disease	6
The lipotype hypothesis	6
Condensates trail the nucleus	5
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation	5
Probing cytoskeletal remodelling by cutting and marking filaments	5
Compression as a driver of hair loss	5
Principles and dynamics of spindle assembly checkpoint signalling	5
A catalytic function for mammalian Argonautes	5
BERing transcriptional noise for cell plasticity	5
How embryos sort themselves out	4
The memory of viscosity	4
Molecular machineries shaping the mitochondrial inner membrane	4
A histone code controls positional identity in limb regeneration	4
Regulation of microtubule dynamics, mechanics and function through the growing tip	4
DNA modifications walk a fine line between epigenetics and mutagenesis	4
Challenges and opportunities in macromolecular structure determination	4
Regulation and functions of non-m6A mRNA modifications	4
MYC in TOP shape	3
Base editing of organellar DNA with programmable deaminases	3
Mechanisms of mechanotransduction and physiological roles of PIEZO channels	3
Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer	3
Senescent cells support limb regeneration	3
Regulation of and challenges in targeting NAD+ metabolism	3
A guide to machine learning for biologists	3
Genome doubling — twice the same is not the same	3
The prompt to discover senolytics	3
The neuronal epigenome is special	3
Cell cycle control in cancer	2
The multiple links between actin and mitochondria	2
Control of stem cell renewal and fate by YAP and TAZ	2
Neurons whisper, tissues respond: neurons as orchestrators of stress responses	2
Long non-coding RNAs: definitions, functions, challenges and recommendations	2
A code within the genetic code	2
Good neighbours transfer nucleotides	2
Cytosol-to-nucleus journey of a novel histone PTM	2
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics	2
RNA polymerase II transcription compartments: from multivalent chromatin binding to liquid droplet formation?	2
Fat accumulation in middle-aged male animals	2
A SOX9 switch from regeneration to fibrosis	2
Cell quiescence sends argonaute-2 to transposons	2
Plant hormone regulation of abiotic stress responses	2
A guide to membraneless organelles and their various roles in gene regulation	2
The diffraction limit of light taken by storm	2
Slow cell death helps tissue repair	2
First demonstration of miRNA-dependent mRNA decay	2
Mechanisms of auxin action in plant growth and development	2