Nature Reviews Molecular Cell Biology

Article	Citations
When senescence generates pluripotent stem cells	2077
Tightening the epithelium to control signalling	2003
Histone H1 deamidation regulates DNA double-strand break repair	1266
The secretory pathway gets a molecular framework	1244
A dynamic culture system that models the intricacy of the mammary gland	1130
Advancing single-cell omics and cell-based therapeutics with quantum computing	907
Transfection reflections: fit-for-purpose delivery of nucleic acids	893
DNA-repair-driven cell death compels us to rethink cancer therapies	866
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	759
The translation m(o)TOR that propels regeneration	668
Mechanisms of substrate processing during ER-associated protein degradation	664
Understanding mechanisms of antioxidant action in health and disease	654
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	645
Decoding the Ca2+ signal for salt tolerance	645
The double life of a transcription factor in the cytoplasm	575
Chemical reprogramming of human blood cells	520
Resilience through selective translation	517
The advent of confocal laser scanning microscopy in biological research	512
Programmed ‘DNA splicing’ removes transposons from genes	501
Progress in stem cell-based embryo models and their applications in developmental biology and biomedicine	473
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	445
How proteins sense their cellular environment	404
PIONEARing how DNA sequence composition tunes TF–nucleosome interactions	404
Engineered nanobodies facilitate cryo-EM studies of small proteins	384
Mechanism and regulation of kinesin motors	377

N-glycan-dependent protein maturation and quality control in the ER	338
New insights into activation and function of the AMPK	334
The emerging mechanisms and functions of microautophagy	333
C-degron mimicry confers E3 ligase selectivity	328
Nucleosomes as blueprints of genome architecture	312
Telomere function and regulation from mouse models to human ageing and disease	303
The discovery of oncogene-induced senescence	303
Silencing centromeres with age	294
Bookmarking pluripotency genes	293
Coordination of cardiogenesis in vivo and in vitro	288
DNA looping regulates transcription	285
Studying lysosomal function and dysfunction using LysoIP	284
CRISPR–Cas applications in agriculture and plant research	283
Biology and therapeutic potential of extracellular vesicle targeting and uptake	260
Regulation, functions and transmission of bivalent chromatin during mammalian development	257
ESCRT-III function in membrane fission and repair	257
Regulation of membrane protein structure and function by their lipid nano-environment	254
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	250
Biology and therapeutic targeting of vascular endothelial growth factor A	245
Mechanisms and roles of podosomes and invadopodia	237
Molecular tools for analysing in vivo senescence	227
A quick guide to (transmembrane) planar cell polarity mouse strains	224
Snoozing APC/C for a sweet cell cycle entry	223
A histone variant that manages abiotic stress in plants	222
Migrasomes promote angiogenesis	216
Science Twitter — navigating change in science communication	211
The RNA world ‘hypothesis’	210
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	201
Improving chemical reprogramming strategies	199
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	197
Context-dependent TGFβ family signalling in cell fate regulation	185
Circadian clock communication during homeostasis and ageing	183
FOXO transcription factors as mediators of stress adaptation	183
Splicing regulation through biomolecular condensates and membraneless organelles	182
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	177
RNA binding — a useful third wheel in transcription	176
Like water on rock, the microenvironment bends stem cell fate	174
Mechanisms and regulation of the Hsp70 chaperone network	169
Energy-driven genome regulation by ATP-dependent chromatin remodellers	169
Subcellular localization as a driver of protein function	168
Mechanisms of mitochondrial respiratory adaptation	164
Context-specific regulation and function of mRNA alternative polyadenylation	157
Activation of human endogenous retroviruses and its physiological consequences	156
Does species-specific alternative splicing make us human?	150
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	147
Organelles stick together through PDZD8-mediated condensate formation	138
How ancient RNA survives and what we can learn from it	138
Molecular machineries and pathways of mitochondrial protein transport	137
Regulation and function of insulin and insulin-like growth factor receptor signalling	136
Targeted protein degradation: from mechanisms to clinic	130

Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	127
A guide to cell death pathways	125
Myosin VI assists in fork protection	124
The centromere as a tag of self-DNA	123
Cold-induced longevity through proteasome boosting	119
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	113
Decoding ubiquitin signals inside cells	109
Redox-driven cell death by disulfidptosis and its therapeutic potential	107
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	104
New frontiers in quality control: the case of GPI-anchored proteins	103
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	101
The molecular basis for cellular function of intrinsically disordered protein regions	100
DEI conversations: more than a box-ticking exercise	97
The technological landscape and applications of single-cell multi-omics	97
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	96
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	95
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	94
Genome characteristics at the borders	94
Anticancer effects of zotatifin are mediated by RNA structure remodelling	94
Fat cells have long-lasting (epigenetic) memory	91
New developments and applications of human organoids	90
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	85
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	85
Microenvironmental determinants of endothelial cell heterogeneity	83
The role and regulation of integrins in cell migration and invasion	82
Unravelling oocyte ultrastructure	81
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	80
Transcription factors crossing the cell membrane	79
Profiling the disordered proteome in cells using a chemical tag	79
The contribution of databases towards understanding the universe of long non-coding RNAs	77
From shortening telomeres to replicative crisis	75
How green is your science? The race to make laboratories sustainable	73
The hunter becomes the hunted in target-directed microRNA degradation	73
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	69
Ethylene — the lifeguard hormone	68
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	67
Neural crest gene regulatory networks as drivers of development, diversification and disease	66
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	66
Exercise metabolism and adaptation in skeletal muscle	65
Mechanisms and regulation of substrate degradation by the 26S proteasome	58
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	56
Cellular role of TETs in early embryos	52
Publisher Correction: Advancing single-cell omics and cell-based therapeutics with quantum computing	48
Translation feedback control in the brain	48
Cis-regulatory elements that tune transcriptional responses in liver drug metabolism and outcomes	46
Following the electric current	45
Stem cell sources of colon cancer in mice	44
Author Correction: The role of the haematopoietic stem cell niche in development and ageing	42
Overcoming cytoskeleton instability in the early embryo	41
Organization of replicated chromosomes by DNA loops and sister chromatid cohesion	40
The senescence-associated secretory phenotype and its physiological and pathological implications	39
Cellular and molecular control of vertebrate somitogenesis	39
The birth of evo-devo	38
Calcium connects lysosomal damage to stress granule formation	38
SWI/SNF chromatin remodellers persist through mitosis	37
Mechanisms and regulation of DNA end resection in the maintenance of genome stability	36
Nuclear speckles of GC richness	35
The bioethics of synthetic cells	34
Tissue injury leads to the accumulation of somatic mtDNA mutations	33
Collective cell migration modes in development, tissue repair and cancer	31
The bystander effect of pyroptosis	31
Deciphering ADP-ribosylation signalling	31
Mediat(or)ing adult stem cells by XIST	30
Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking	29
Harnessing fluorescent probes to unveil dynamic membrane mechanics	27
Functions and therapeutic applications of pseudouridylation	27
Spatiotemporal control over cell–matrix interactions using dynamic micropatterns	25
ncRNA regulation of mitochondrial transcription	24
Microtubules provide a mechanical link for YAP/TAZ signalling	23
Voices of the new generation: my unconventional way to stay in academia	23
Proteins that assemble co-translationally lean on their partner for stability	22
The emergence of MARUbe — a hybrid ADP-ribose–ubiquitin modification	22
Phase separation across membranes and condensates in cell organization and function	22
ERMES — from myths to molecules	21
The mechanistic basis and cellular functions of UFMylation	19
Signalling mechanisms and cellular functions of SUMO	19
Local and systemic mechanisms that control the hair follicle stem cell niche	19
Present and future of synthetic cell development	18
Lasker Award for AlphaFold	17
Mechanical state transitions in the regulation of tissue form and function	17

Smelling your way to longevity	17
Sorting membrane proteins by size in the Golgi	17
Epigenetic discovery by enzyme activity profiling	16
Internal-m7G-modified mRNAs quake under stress	16
Blebbisomes are one bleb away from a functional cell	15
Revealing the hidden coding potential of the human genome	15
Decoding the interactions and functions of non-coding RNA with artificial intelligence	15
A nuclear morphology-based machine learning algorithm for senescence detection	14
Regulation of RNA-binding proteins by small biomolecules	14
The birth of stable introns	13
Size matters	13
Mitochondrial ROS drive cell cycle progression	12
Translating the midbody for cytokinesis	12
Early insights into co-translational assembly of protein complexes	12
The nuance in DNA and transcription factor interactions	12
Enabling RNA-compatible synthetic receptors through RNA editing	12
Cellular functions of eukaryotic RNA helicases and their links to human diseases	11
Critical constituents and assembly principles of centriole biogenesis in human cells	11
The discovery of cyclin-dependent kinases	11
The emerging importance of UBA6 in ubiquitylation and proteostasis	11
Genome control by SMC complexes	10
Prevailing views of cell senescence overlook its biological complexity	10
Mechanistic insights into gasdermin-mediated pyroptosis	10
BCL-2 proteins in senescence: beyond a simple target for senolysis?	10
The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance	10
Mechanisms and regulation of human mitochondrial transcription	10
Single-cell lipidomics reveals the organizing principle of cell fate decision	9
Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target	9
Monitoring subcellular protein localization at scale in live cells	9
Viruses show the way	9
Goodbye, senescent cells: CAR-T cells unleashed to fight ageing	8
Paleoproteomics sheds light on million-year-old fossils	8
Shaping epithelial tissues by stem cell mechanics in development and cancer	8
Publisher Correction: Mechanisms and regulation of the Hsp70 chaperone network	8
Exploring the uncharted landscape of truncated mRNAs	7
Protrusion-derived vesicles: new subtype of EVs?	7
Author Correction: Fundamentals of redox regulation in biology	7
Cell–extracellular matrix mechanotransduction in 3D	7
A novel photosystem assembly line worker	7
Towards a unified framework for the function of endoplasmic reticulum exit sites	7
Uncovering mRNA sequences that control translation initiation	7
Key challenges and recommendations for defining organelle membrane contact sites	6
Modes of Notch signalling in development and disease	6
The double-edged sword of bivalency	6
Modelling human brain development and disease with organoids	6
The lipotype hypothesis	6
Principles and dynamics of spindle assembly checkpoint signalling	6
Author Correction: Molecular machineries and pathways of mitochondrial protein transport	6
Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation	5
Turning the replisome around	5
Heterogeneity, dynamics and organelle interactions of lipid droplets	5
A catalytic function for mammalian Argonautes	5
The role of the haematopoietic stem cell niche in development and ageing	5
The prompt to discover senolytics	5
How embryos sort themselves out	4
Base editing of organellar DNA with programmable deaminases	4
Illuminating protein microenvironments with rotor-based fluorescent amino acids	4
Inflammageing and clonal haematopoiesis interplay and their impact on human disease	4
Regulation and functions of non-m6A mRNA modifications	4
Genome doubling — twice the same is not the same	4
Condensates trail the nucleus	4
DNA modifications walk a fine line between epigenetics and mutagenesis	4
The memory of viscosity	4
Molecular machineries shaping the mitochondrial inner membrane	4
Senescent cells support limb regeneration	4
Challenges and opportunities in macromolecular structure determination	4
Probing cytoskeletal remodelling by cutting and marking filaments	4
A histone code controls positional identity in limb regeneration	4
The regulation, function and disease relevance of cytoplasmic tRNAs	4
Regulation of and challenges in targeting NAD+ metabolism	4
Mechanisms of mechanotransduction and physiological roles of PIEZO channels	4
The discovery of simple repeats that cause complex disorders	4
White adipocyte dysfunction and obesity-associated pathologies in humans	3
Plant microRNA maturation and function	3
Long non-coding RNAs: definitions, functions, challenges and recommendations	3
The neuronal epigenome is special	3
SLAM passes the haematopoietic stem cell identity test	3
Modelling tauopathies	3
Mechanisms and functions of protein S-acylation	3
Biochemical and mechanical regulation of actin dynamics	3
The cell biology of ferroptosis	3
A lunapark for secretory mRNA translation at ER junctions	3
Cell quiescence sends argonaute-2 to transposons	3
RNF26 and vimentin orchestrate ER stress recovery	3
The multiple links between actin and mitochondria	3
Uncovering the complexity of RNA–protein interactions	3
Good neighbours transfer nucleotides	3
Fatty acid signalling promotes hair regrowth	3
Distal enhancers loop to proximal enhancers, not to promoters	3