OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Molecular Cell Biology is 55. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
When senescence generates pluripotent stem cells	1728
The translation m(o)TOR that propels regeneration	1666
From trans-splicing discovery and onwards, trypanosomes lead the way	1330
A dynamic culture system that models the intricacy of the mammary gland	1031
Transfection reflections: fit-for-purpose delivery of nucleic acids	1008
DNA-repair-driven cell death compels us to rethink cancer therapies	937
Tightening the epithelium to control signalling	853
Histone H1 deamidation regulates DNA double-strand break repair	770
The secretory pathway gets a molecular framework	764
Mechanisms of substrate processing during ER-associated protein degradation	736
Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids	716
Modulation of cellular processes by histone and non-histone protein acetylation	710
Pore-forming proteins as drivers of membrane permeabilization in cell death pathways	563
Understanding mechanisms of antioxidant action in health and disease	549
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment	534
Decoding the Ca2+ signal for salt tolerance	500
N-glycan-dependent protein maturation and quality control in the ER	467
The double life of a transcription factor in the cytoplasm	459
Chemical reprogramming of human blood cells	433
Resilience through selective translation	425
How proteins sense their cellular environment	425
The phosphoinositide PI5P inhibits the Hippo pathway effector YAP	415
The advent of confocal laser scanning microscopy in biological research	412
Publisher Correction: Plant hormone regulation of abiotic stress responses	399
The emerging mechanisms and functions of microautophagy	383

New insights into activation and function of the AMPK	374
Mechanism and regulation of kinesin motors	368
Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance	367
The healing role of gasdermin B in IBD	359
C-degron mimicry confers E3 ligase selectivity	355
Nucleosomes as blueprints of genome architecture	351
Studying lysosomal function and dysfunction using LysoIP	346
Silencing centromeres with age	327
DNA looping regulates transcription	318
Coordination of cardiogenesis in vivo and in vitro	305
CRISPR–Cas applications in agriculture and plant research	302
Telomere function and regulation from mouse models to human ageing and disease	290
Bookmarking pluripotency genes	268
The discovery of oncogene-induced senescence	260
ESCRT-III function in membrane fission and repair	258
Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation	257
Biology and therapeutic targeting of vascular endothelial growth factor A	254
Mechanisms and roles of podosomes and invadopodia	249
Regulation, functions and transmission of bivalent chromatin during mammalian development	246
Regulation of membrane protein structure and function by their lipid nano-environment	237
Curvature-mediated endocytosis	231
Molecular tools for analysing in vivo senescence	227
A quick guide to (transmembrane) planar cell polarity mouse strains	225
Snoozing APC/C for a sweet cell cycle entry	225
A histone variant that manages abiotic stress in plants	218
Improving chemical reprogramming strategies	217
Migrasomes promote angiogenesis	215
Publisher Correction: Emerging roles and functional mechanisms of PIWI- interacting RNAs	213
The prospects and opportunities of protein structure prediction with AI	212
The RNA world ‘hypothesis’	210
Science Twitter — navigating change in science communication	199
Circadian clock communication during homeostasis and ageing	197
Splicing regulation through biomolecular condensates and membraneless organelles	189
Context-dependent TGFβ family signalling in cell fate regulation	188
Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens	182
Why novel mRNA modifications are so challenging and what we can do about it	181
A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals	175
FOXO transcription factors as mediators of stress adaptation	175
Transposons: catch them if you can	171
RNA binding — a useful third wheel in transcription	170
Like water on rock, the microenvironment bends stem cell fate	165
Mechanisms and regulation of the Hsp70 chaperone network	162
New tool for MAPping microtubule dynamics	162
Activation of human endogenous retroviruses and its physiological consequences	160
Energy-driven genome regulation by ATP-dependent chromatin remodellers	159
Mechanisms of mitochondrial respiratory adaptation	154
Context-specific regulation and function of mRNA alternative polyadenylation	149
Integrated biophysical imaging of cell interactions with 3D extracellular matrices	145
Does species-specific alternative splicing make us human?	145
Revisiting small RNA movement in plants	144

How ancient RNA survives and what we can learn from it	141
Molecular machineries and pathways of mitochondrial protein transport	138
Regulation and function of insulin and insulin-like growth factor receptor signalling	137
Transcriptional control of energy metabolism by nuclear receptors	136
A guide to cell death pathways	131
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases	131
Targeted protein degradation: from mechanisms to clinic	131
Apical–basal polarity and the control of epithelial form and function	128
Myosin VI assists in fork protection	123
The centromere as a tag of self-DNA	123
Author Correction: All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	120
Cold-induced longevity through proteasome boosting	114
Decoding ubiquitin signals inside cells	114
New frontiers in quality control: the case of GPI-anchored proteins	113
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex	112
Redox-driven cell death by disulfidptosis and its therapeutic potential	112
Resolution in super-resolution microscopy — definition, trade-offs and perspectives	108
The technological landscape and applications of single-cell multi-omics	106
The molecular basis for cellular function of intrinsically disordered protein regions	105
Polarized endoplasmic reticulum–plasma membrane contacts in cell migration	101
DEI conversations: more than a box-ticking exercise	101
Fat cells have long-lasting (epigenetic) memory	100
Genome characteristics at the borders	99
Anticancer effects of zotatifin are mediated by RNA structure remodelling	98
Author Correction: Regulation of membrane protein structure and function by their lipid nano-environment	95
ATP and ROS signal cell extrusion	89
Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death	85
Mechanisms of microtubule organization in differentiated animal cells	83
Microenvironmental determinants of endothelial cell heterogeneity	83
Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases	81
Interplay between mechanics and signalling in regulating cell fate	80
Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	74
Ethylene — the lifeguard hormone	73
Deep learning shapes single-cell data analysis	73
The role and regulation of integrins in cell migration and invasion	73
Author Correction: Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics	70
Voices of the new generation: importance of emotional ‘match’ in mentoring relationships	68
Unravelling oocyte ultrastructure	68
From shortening telomeres to replicative crisis	65
Transcription factors crossing the cell membrane	61
Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles	61
Profiling the disordered proteome in cells using a chemical tag	61
Mechanisms and regulation of substrate degradation by the 26S proteasome	60
How green is your science? The race to make laboratories sustainable	59
The contribution of databases towards understanding the universe of long non-coding RNAs	58
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis	58
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies	58
The hunter becomes the hunted in target-directed microRNA degradation	58
Karyopherin-mediated nucleocytoplasmic transport	55