OOIR: Observatory of International Research

Papers

(The median citation count of Current Opinion in Pharmacology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Corrigendum to “From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling” [COPHAR 76 (2024) 102458]	112
Editorial Board	101
The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies	86
From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling	74
The role of extracellular ATP in homeostatic immune cell migration	55
Advances in pain therapeutics: Targets, mechanisms, and translational frontiers	53
Therapeutic hurdles in acute myeloid leukemia: Leukemic stem cells, inflammation and immune dysfunction	52
Lipid raft disruption as an opportunity for peripheral analgesia	47
Native botulinum toxin type A vs. redesigned botulinum toxins in pain: What did we learn so far?	42
Targeting Strategies and Immune Regulatory Mechanisms of CAR-Macrophages in the Treatment of Osteosarcoma	39
Lipidomics-driven Insights into Acupuncture Mechanisms: From Dynamic Signaling Networks to Multidimensional Regulations	39
Optofluidic neural interfaces for in vivo photopharmacology	38
Recent advances in emerging PCOS therapies	38
Photo-isomerizable tweezers to probe ionotropic receptor mechanisms	36
Gastrointestinal issue: Advances in gastrointestinal oncology	35
Editorial Board	35
Optic nerve regeneration: Potential treatment approaches	34
CRISPR-Cas9 in acute myeloid leukaemia: Current state-of-art and future perspectives	34
Considerations for individualized first-line systemic treatment in advanced hepatocellular carcinoma	33
Pancreatic alpha cells and glucagon secretion: Novel functions and targets in glucose homeostasis	31
Advanced microneedle arrays for transdermal antibiotic delivery	30
Editorial Board	30
Editorial overview: Special issue on “Rheumatology: Therapeutic advances for autoimmune and musculoskeletal diseases”	30
Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistance	28
Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration	28

Animal models of cystic fibrosis in the era of highly effective modulator therapies	27
Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis	25
Current state of CFTR modulators for treatment of Cystic Fibrosis	25
Editorial Board	25
Editorial Board	23
Gene therapies for RyR1-related myopathies	23
Allogeneic double-negative T-cell therapy for acute myeloid leukemia	23
Therapeutic approaches in different congenital myopathies	22
Editorial overview: An initiative toward Ebolavirus disease (EVD) free world: An edited special anti-infective issue on Ebola virus disease	21
Photopharmacological approaches for dissecting potassium channel physiology	21
Oncohistone-sculpted epigenetic mechanisms in pediatric brain cancer	21
Strategies to enhance anti-leukaemia immunotherapy	21
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside	21
Drug development for the treatment of RyR1-related skeletal muscle diseases	20
Antihypertensive effect of soybean bioactive peptides: A review	20
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration	20
Lipids and lipid regulators in intraocular pressure homeostasis	20
Smart solutions for tough infections: The rise of next-gen transdermal drug delivery	20
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer	20
Oligonucleotide-based therapies for cystic fibrosis	20
Functional role of the ER stress transducer IRE1α in CF airway epithelial inflammation	19
Photopharmacological control of cell signaling with photoswitchable lipids	19
Antibiotics, the microbiome and gastrointestinal cancers: A causal interference?	19
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”	19
Light-activated receptor tyrosine kinases: Designs and applications	18
Editorial overview: COVID-19 therapy: From lung disease to systemic disorder	18
Purinergic signalling in graft-versus-host disease	17
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway	17
Challenges in formulating transdermal systems for treating chronic skin infections	17
TMEM16A regulates MUC5AC production in airway diseases:A Comprehensive Review	17
Advancements in targeted therapies for acute myeloid leukemia	16
Pharmacoutilization data-driven artificial intelligence–assisted diagnosis algorithm to improve the pharmacological treatment of pain and agitation in patients suffering from severe dementia	16
Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies	16
Targeting fibroblast-like synoviocytes in rheumatoid arthritis	16
Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction	16
Editorial Board	15
Novel approaches to CAR T cell target identification in acute myeloid leukemia	15
Editorial overview: Introduction to the musculoskeletal section of current opinion in pharmacology	15
NMR applications to GPCR recognition by peptide ligands	15
CFTR RNA- and DNA-based therapies	14
The expanding role of split protein complementation in opsin-free optogenetics	14
AI-driven GPCR analysis, engineering, and targeting	14
PRRT for higher-grade neuroendocrine neoplasms: What is still acceptable?	14
Editorial Board	14
Effects of protein glycation and protective mechanisms against glycative stress	14
Targeting the endocannabinoid system for the management of low back pain	14
Revolutionizing UC monitoring: The emerging role of intestinal ultrasound	14
Novel treatments for dry eye syndrome	14
TMEM16A (ANO1) as a therapeutic target in cystic fibrosis	14
Editorial Board	14

Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscle	14
Fluorescent chemigenetic actuators and indicators for use in living animals	14
Immune dysfunction after spinal cord injury – A review of autonomic and neuroendocrine mechanisms	14
Advances in tethered photopharmacology for precise optical control of signaling proteins	14
Environmental toxicants, brown adipose tissue, and potential links to obesity and metabolic disease	14
Is there still a place for radiotherapy in gastric cancer?	13
Dysregulation of immune checkpoint proteins in hepatocellular carcinoma: Impact on metabolic reprogramming	13
The molecular link between oxidative stress, insulin resistance, and type 2 diabetes: A target for new therapies against cardiovascular diseases	13
Innate and adaptive immune mechanisms regulating central nervous system remyelination	13
Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation	13
Corrigendum to “Antihypertensive effect of soybean bioactive peptides: A review” [Curr Opin Pharmacol (62) (2022) 74–81]	13
Anabolic–androgenic steroid abuse and testicular function in men; recent insights	12
Editorial overview: Advanced therapies and new targets in ocular diseases	12
Current and new targets for treating myositis	12
Physiological regulation of leptin as an integrative signal of reproductive readiness	12
Mechanisms of cardio-renal protection of sodium-glucose cotransporter-2 inhibitors	11
Lipid-based nanocarriers in topical applications for skin infections	11
Newly identified tumor suppressor functions of ING proteins	11
Revolutionizing Crohn's disease monitoring: The emerging role of intestinal ultrasound	11
A review of biosimilars for rheumatoid arthritis	11
Recent insights into astrocytes as therapeutic targets for demyelinating diseases	11
Treatment of alcohol use disorder in patients with liver disease	11
Targeting PKC in microglia to promote remyelination and repair in the CNS	11
Precision medicine and immunotherapeutic approaches for relapsed/refractory paediatric acute myeloid leukaemia	10
Treatment advances in antiphospholipid syndrome: 2022 update	10
Interrogating the function of GABAA receptors in the brain with optogenetic pharmacology	10
Novel strategies to promote resolution of inflammation to treat lower extremity artery disease	10
Applications of chemogenetics in non-human primates	9
Impact of amino acids on microglial activation and CNS remyelination	9
Biased signalling in analgesic research and development	9
New developments in treatments for systemic vasculitis	9
Hormonal drugs for the treatment of endometriosis	9
The use of hormone stimulation in male infertility	9
Recent innovations in clinical trial design for inflammatory bowel disease	9
Health benefits of spices in individuals with chemotherapeutic drug-induced cardiotoxicity	9
Interventional functional diagnostics in gastrointestinal endoscopy: Combining diagnostic and therapeutic tools in the endoscopy suite with the functional lumen imaging probe	9
Optical control of Class A G protein-coupled receptors with photoswitchable ligands	9
Colloidal drug delivery systems for infectious diseases of skin	9
RAD51 paralogs: Expanding roles in replication stress responses and repair	9
Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors	8
High-quality randomised controlled trials of acupuncture interventions for autism spectrum disorder in the last 10 years (2015–2024): A literature review	8
Editorial Board	8
Update on anti-fibrotic pharmacotherapies in skeletal muscle disease	8
Current treatment and molecular targets for axial spondyloarthritis: Evidence from randomized controlled trials	8
Making myelin regenerate: Factors to consider	8
Breaking the barriers to remyelination in multiple sclerosis	7
Immune-mediated food reactions in irritable bowel syndrome	7
Novel therapeutic avenues for kisspeptin	7
Therapeutic opportunities for targeting cellular senescence in progressive multiple sclerosis	7
Molecular insights driving personalized therapies	7
Extracellular adenosine signaling in bone health and disease	7
Editorial: Nutraceuticals	7
Microglia as therapeutic targets for central nervous system remyelination	6
Reprogramming cell fates towards novel cancer immunotherapies	6
Impaired metabolism of oligodendrocyte progenitor cells and axons in demyelinated lesion and in the aged CNS	6
COVID-19 in Latin America and the caribbean region: Symptoms and morbidities in the epidemiology of infection	6
Routine neoadjuvant chemotherapy for all patients with resectable pancreatic ductal adenocarcinoma? A review of the evidence	6
Treatments for COVID-19: Lessons from 2020 and new therapeutic options	6
Towards development of disease-modifying therapy for Alzheimer's disease using redox chemical biology pathways	6
The changing landscape of the cystic fibrosis lung environment: From the perspective of Pseudomonas aeruginosa	6
Emerging strategies for treating gout	6
In the heart and beyond: Mitochondrial dysfunction in heart failure with preserved ejection fraction (HFpEF)	6
Treatment approach to connective tissue disease-associated interstitial lung disease	6
Immune cell subtype contributions to doxorubicin cardiotoxicity–defining immune targets for translational interventions	6
Seeing is believing: Identifying remyelination in the central nervous system	6
Overview of CF lung pathophysiology	6
Shaping surgical decisions in IBD — Unveiling the power of intestinal ultrasound across the perioperative pathway	6