OOIR: Observatory of International Research

Papers

(The median citation count of Current Opinion in Pharmacology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Therapeutic hurdles in acute myeloid leukemia: Leukemic stem cells, inflammation and immune dysfunction	115
Corrigendum to “From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling” [COPHAR 76 (2024) 102458]	109
Editorial Board	96
Native botulinum toxin type A vs. redesigned botulinum toxins in pain: What did we learn so far?	80
From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling	68
The role of extracellular ATP in homeostatic immune cell migration	52
Lipid raft disruption as an opportunity for peripheral analgesia	52
The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies	47
Recent advances in emerging PCOS therapies	45
Considerations for individualized first-line systemic treatment in advanced hepatocellular carcinoma	41
Optofluidic neural interfaces for in vivo photopharmacology	40
Photo-isomerizable tweezers to probe ionotropic receptor mechanisms	38
Editorial Board	38
Gastrointestinal issue: Advances in gastrointestinal oncology	36
CRISPR-Cas9 in acute myeloid leukaemia: current state-of-art and future perspectives	34
Optic nerve regeneration: Potential treatment approaches	34
Pancreatic alpha cells and glucagon secretion: Novel functions and targets in glucose homeostasis	33
Editorial overview: Special issue on “Rheumatology: Therapeutic advances for autoimmune and musculoskeletal diseases”	32
Advanced microneedle arrays for transdermal antibiotic delivery	31
Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration	31
Editorial Board	31
Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistance	28
Three-dimensional culture models to study glioblastoma — current trends and future perspectives	28
Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus	28
Current state of CFTR modulators for treatment of Cystic Fibrosis	27

Allogeneic double-negative T-cell therapy for acute myeloid leukemia	27
Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis	27
Editorial Board	26
Animal models of cystic fibrosis in the era of highly effective modulator therapies	25
Therapeutic approaches in different congenital myopathies	25
Editorial Board	25
Gene therapies for RyR1-related myopathies	24
Strategies to enhance anti-leukaemia immunotherapy	23
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside	23
Oncohistone-sculpted epigenetic mechanisms in pediatric brain cancer	22
Oligonucleotide-based therapies for cystic fibrosis	22
Antihypertensive effect of soybean bioactive peptides: A review	22
Lipids and lipid regulators in intraocular pressure homeostasis	22
Next-gen therapeutics to spare and expand beta-cell mass	21
Editorial overview: An initiative toward Ebolavirus disease (EVD) free world: An edited special anti-infective issue on Ebola virus disease	21
Non-alcoholic fatty liver disease: Current therapeutic options	20
Drug development for the treatment of RyR1-related skeletal muscle diseases	20
Smart solutions for tough infections: The rise of next-gen transdermal drug delivery	20
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer	20
Photopharmacological approaches for dissecting potassium channel physiology	20
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”	19
Nutraceuticals in mental diseases — Bridging the gap between traditional use and modern pharmacology	19
Photopharmacological control of cell signaling with photoswitchable lipids	19
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway	19
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration	19
Challenges in formulating transdermal systems for treating chronic skin infections	19
Purinergic signalling in graft-versus-host disease	18
Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies	18
Antibiotics, the microbiome and gastrointestinal cancers: A causal interference?	18
Light-activated receptor tyrosine kinases: Designs and applications	17
Functional role of the ER stress transducer IRE1α in CF airway epithelial inflammation	17
Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction	17
Targeting fibroblast-like synoviocytes in rheumatoid arthritis	17
Editorial overview: COVID-19 therapy: From lung disease to systemic disorder	17
Advances in tethered photopharmacology for precise optical control of signaling proteins	16
NMR applications to GPCR recognition by peptide ligands	16
The expanding role of split protein complementation in opsin-free optogenetics	16
AI-driven GPCR analysis, engineering, and targeting	16
Pharmacoutilization data-driven artificial intelligence–assisted diagnosis algorithm to improve the pharmacological treatment of pain and agitation in patients suffering from severe dementia	16
Editorial Board	16
Novel approaches to CAR T cell target identification in acute myeloid leukemia	16
Targeting the endocannabinoid system for the management of low back pain	15
Editorial overview: Introduction to the musculoskeletal section of current opinion in pharmacology	15
Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscle	15
CFTR RNA- and DNA-based therapies	15
Fluorescent chemigenetic actuators and indicators for use in living animals	15
Novel treatments for dry eye syndrome	15
Effects of protein glycation and protective mechanisms against glycative stress	14
Is there still a place for radiotherapy in gastric cancer?	14
Caffeine consumption and schizophrenia: A highlight on adenosine receptor–independent mechanisms	14

TMEM16A (ANO1) as a therapeutic target in cystic fibrosis	14
Editorial Board	14
Corrigendum to “Antihypertensive effect of soybean bioactive peptides: A review” [Curr Opin Pharmacol (62) (2022) 74–81]	14
Immune dysfunction after spinal cord injury – A review of autonomic and neuroendocrine mechanisms	14
PRRT for higher-grade neuroendocrine neoplasms: What is still acceptable?	14
Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation	14
Editorial Board	14
Innate and adaptive immune mechanisms regulating central nervous system remyelination	13
Anabolic–androgenic steroid abuse and testicular function in men; recent insights	13
Recent insights into astrocytes as therapeutic targets for demyelinating diseases	13
The molecular link between oxidative stress, insulin resistance, and type 2 diabetes: A target for new therapies against cardiovascular diseases	13
Mechanisms of cardio-renal protection of sodium-glucose cotransporter-2 inhibitors	13
Targeting PKC in microglia to promote remyelination and repair in the CNS	13
Dysregulation of immune checkpoint proteins in hepatocellular carcinoma: Impact on metabolic reprogramming	13
Environmental toxicants, brown adipose tissue, and potential links to obesity and metabolic disease	13
Editorial overview: Advanced therapies and new targets in ocular diseases	13
Physiological regulation of leptin as an integrative signal of reproductive readiness	13
Treatment advances in antiphospholipid syndrome: 2022 update	12
Current and new targets for treating myositis	12
Lipid-based nanocarriers in topical applications for skin infections	12
Melatonin in neuroskeletal biology	12
Newly identified tumor suppressor functions of ING proteins	12
Treatment of alcohol use disorder in patients with liver disease	12
A review of biosimilars for rheumatoid arthritis	12
Interrogating the function of GABAA receptors in the brain with optogenetic pharmacology	11
Impact of amino acids on microglial activation and CNS remyelination	11
Applications of chemogenetics in non-human primates	11
Novel strategies to promote resolution of inflammation to treat lower extremity artery disease	11
Interventional functional diagnostics in gastrointestinal endoscopy: Combining diagnostic and therapeutic tools in the endoscopy suite with the functional lumen imaging probe	11
Precision medicine and immunotherapeutic approaches for relapsed/refractory paediatric acute myeloid leukaemia	11
New developments in treatments for systemic vasculitis	11
Colloidal drug delivery systems for infectious diseases of skin	10
RAD51 paralogs: Expanding roles in replication stress responses and repair	10
Biased signalling in analgesic research and development	10
Hormonal drugs for the treatment of endometriosis	10
Optical control of Class A G protein-coupled receptors with photoswitchable ligands	10
Health benefits of spices in individuals with chemotherapeutic drug-induced cardiotoxicity	10
Therapeutic opportunities for targeting cellular senescence in progressive multiple sclerosis	9
Making myelin regenerate: Factors to consider	9
Recent innovations in clinical trial design for inflammatory bowel disease	9
Current treatment and molecular targets for axial spondyloarthritis: Evidence from randomized controlled trials	9
Editorial Board	9
Update on anti-fibrotic pharmacotherapies in skeletal muscle disease	9
The use of hormone stimulation in male infertility	9
Novel therapeutic avenues for kisspeptin	9
Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors	9
MedXercise: a promising strategy to promote remyelination	9
Extracellular adenosine signaling in bone health and disease	8
Treatment approach to connective tissue disease-associated interstitial lung disease	8
Molecular insights driving personalized therapies	8
Immune-mediated food reactions in irritable bowel syndrome	8
Gastrointestinal manifestations and SARS-CoV-2 infection	8
Towards development of disease-modifying therapy for Alzheimer's disease using redox chemical biology pathways	8
Reprogramming cell fates towards novel cancer immunotherapies	8
Editorial: Nutraceuticals	8
Microglia as therapeutic targets for central nervous system remyelination	8
Breaking the barriers to remyelination in multiple sclerosis	8
Impaired metabolism of oligodendrocyte progenitor cells and axons in demyelinated lesion and in the aged CNS	7
In the heart and beyond: Mitochondrial dysfunction in heart failure with preserved ejection fraction (HFpEF)	7
Seeing is believing: Identifying remyelination in the central nervous system	7
Treatments for COVID-19: Lessons from 2020 and new therapeutic options	7
Emerging strategies for treating gout	7
The changing landscape of the cystic fibrosis lung environment: From the perspective of Pseudomonas aeruginosa	7
The active kinome: The modern view of how active protein kinase networks fit in biological research	6
COVID-19 in Latin America and the caribbean region: Symptoms and morbidities in the epidemiology of infection	6
Routine neoadjuvant chemotherapy for all patients with resectable pancreatic ductal adenocarcinoma? A review of the evidence	6
Drug effects on neuropeptides and their receptors: Big hopes but moderate success in the treatment of chronic pain	6
Overview of CF lung pathophysiology	6
Editorial Board	6
Editorial Board	6
Dietary serine supplementation: Friend or foe?	6
Stress, kisspeptin, and functional hypothalamic amenorrhea	6