OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Pharmacology is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Native botulinum toxin type A vs. redesigned botulinum toxins in pain: What did we learn so far?	104
Editorial Board	94
Splice-switching as cancer therapy	92
Therapeutic hurdles in acute myeloid leukemia: Leukemic stem cells, inflammation and immune dysfunction	69
The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies	62
The role of extracellular ATP in homeostatic immune cell migration	59
From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling	50
Recent advances in emerging PCOS therapies	49
Lipid raft disruption as an opportunity for peripheral analgesia	47
Gastrointestinal issue: Advances in gastrointestinal oncology	42
Editorial Board	40
Technological advancements to study cellular signaling pathways in inherited retinal degenerative diseases	38
Optofluidic neural interfaces for in vivo photopharmacology	37
Optic nerve regeneration: Potential treatment approaches	35
Photo-isomerizable tweezers to probe ionotropic receptor mechanisms	35
Artemisinins and their impact on inhibitory neurotransmission	34
Considerations for individualized first-line systemic treatment in advanced hepatocellular carcinoma	33
Pancreatic alpha cells and glucagon secretion: Novel functions and targets in glucose homeostasis	33
Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistance	32
Advanced microneedle arrays for transdermal antibiotic delivery	32
Editorial overview: Special issue on “Rheumatology: Therapeutic advances for autoimmune and musculoskeletal diseases”	31
A review of emerging neuroprotective and neuroregenerative therapies in traumatic spinal cord injury	30
Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration	30
Three-dimensional culture models to study glioblastoma — current trends and future perspectives	29
Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus	29

Editorial Board	27
Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis	27
Allogeneic double-negative T-cell therapy for acute myeloid leukemia	27
Effects of functional electrical stimulation on muscle health after spinal cord injury	26
Exercise as a drug for glucose management and prevention in type 2 diabetes mellitus	26
Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration	25
Current state of CFTR modulators for treatment of Cystic Fibrosis	25
Animal models of cystic fibrosis in the era of highly effective modulator therapies	25
Editorial Board	24
Plant-based vaccine research development against viral diseases with emphasis on Ebola virus disease: A review study	24
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside	24
Therapeutic approaches in different congenital myopathies	23
Promising therapeutic approaches in pulmonary arterial hypertension	23
Integrating single-cell transcriptomics and microcircuit computer modeling	23
Gene therapies for RyR1-related myopathies	22
Oligonucleotide-based therapies for cystic fibrosis	22
Editorial overview: An initiative toward Ebolavirus disease (EVD) free world: An edited special anti-infective issue on Ebola virus disease	22
Very-low-calorie ketogenic diet: An alternative to a pharmacological approach to improve glycometabolic and gonadal profile in men with obesity	22
Next-gen therapeutics to spare and expand beta-cell mass	22
Lipids and lipid regulators in intraocular pressure homeostasis	21
Strategies to enhance anti-leukaemia immunotherapy	21
Photopharmacological approaches for dissecting potassium channel physiology	21
Autophagy in neuronal physiology and disease	20
Oncohistone-sculpted epigenetic mechanisms in pediatric brain cancer	20
Antihypertensive effect of soybean bioactive peptides: A review	20
Treatment of severe alcoholic hepatitis: A systematic review	20
MicroRNA: A mediator of diet-induced cardiovascular protection	19
Nutraceuticals in mental diseases — Bridging the gap between traditional use and modern pharmacology	19
Drug development for the treatment of RyR1-related skeletal muscle diseases	19
Non-alcoholic fatty liver disease: Current therapeutic options	19
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”	19
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration	19
Host membrane proteins in the HIV-induced membrane fusion: Role in pathogenesis and therapeutic potential of autoantibodies	19
Photopharmacological control of cell signaling with photoswitchable lipids	18
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer	18
Editorial overview: COVID-19 therapy: From lung disease to systemic disorder	18
Organotypic human ex vivo models for coronavirus disease 2019 research and drug development	18
Adoptive cell therapy for solid tumors: Chimeric antigen receptor T cells and beyond	18
Functional role of the ER stress transducer IRE1α in CF airway epithelial inflammation	17
Purinergic signalling in graft-versus-host disease	17
Challenges in formulating transdermal systems for treating chronic skin infections	17
Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction	17
Light-activated receptor tyrosine kinases: Designs and applications	17
Antibiotics, the microbiome and gastrointestinal cancers: A causal interference?	17
Editorial Board	16
CFTR RNA- and DNA-based therapies	16
Editorial overview: Introduction to the musculoskeletal section of current opinion in pharmacology	16
Targeting fibroblast-like synoviocytes in rheumatoid arthritis	16
Fluorescent chemigenetic actuators and indicators for use in living animals	16
PRRT for higher-grade neuroendocrine neoplasms: What is still acceptable?	16

Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies	16
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway	16
AI-driven GPCR analysis, engineering, and targeting	16
Pharmacoutilization data-driven AI-assisted diagnosis algorithm to improve the pharmacological treatment of pain and agitation in patients suffering from severe dementia	15
Novel approaches to CAR T cell target identification in acute myeloid leukemia	15
The expanding role of split protein complementation in opsin-free optogenetics	15
NMR applications to GPCR recognition by peptide ligands	15
Advances in tethered photopharmacology for precise optical control of signaling proteins	15
Targeting the endocannabinoid system for the management of low back pain	15
Effects of protein glycation and protective mechanisms against glycative stress	15
Immune dysfunction after spinal cord injury – A review of autonomic and neuroendocrine mechanisms	15
Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscle	15
Towards eradication of HBV: Treatment approaches and status of clinical trials	15