OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Pharmacology is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Native botulinum toxin type A vs. redesigned botulinum toxins in pain: What did we learn so far?	97
Editorial Board	86
The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies	82
Splice-switching as cancer therapy	63
Therapeutic hurdles in acute myeloid leukemia: Leukemic stem cells, inflammation and immune dysfunction	59
Lipid raft disruption as an opportunity for peripheral analgesia	58
From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling	45
Recent advances in emerging PCOS therapies	44
The role of extracellular ATP in homeostatic immune cell migration	44
Gastrointestinal issue: Advances in gastrointestinal oncology	37
Editorial Board	36
Technological advancements to study cellular signaling pathways in inherited retinal degenerative diseases	35
Current status of hepatitis delta	33
Considerations for individualized first-line systemic treatment in advanced hepatocellular carcinoma	33
Optic nerve regeneration: Potential treatment approaches	32
Optofluidic neural interfaces for in vivo photopharmacology	31
Pancreatic alpha cells and glucagon secretion: Novel functions and targets in glucose homeostasis	30
Artemisinins and their impact on inhibitory neurotransmission	30
Editorial overview: Special issue on “Rheumatology: Therapeutic advances for autoimmune and musculoskeletal diseases”	30
Photo-isomerizable tweezers to probe ionotropic receptor mechanisms	30
Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistance	29
Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration	29
Advanced Microneedle Arrays for Transdermal Antibiotic Delivery	28
Three-dimensional culture models to study glioblastoma — current trends and future perspectives	27
Editorial Board	27

Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus	27
A review of emerging neuroprotective and neuroregenerative therapies in traumatic spinal cord injury	27
Animal models of cystic fibrosis in the era of highly effective modulator therapies	27
Effects of functional electrical stimulation on muscle health after spinal cord injury	25
Exercise as a drug for glucose management and prevention in type 2 diabetes mellitus	25
Current state of CFTR modulators for treatment of Cystic Fibrosis	24
Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis	23
Plant-based vaccine research development against viral diseases with emphasis on Ebola virus disease: A review study	23
Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration	23
Next-gen therapeutics to spare and expand beta-cell mass	22
Gene therapies for RyR1-related myopathies	22
Promising therapeutic approaches in pulmonary arterial hypertension	22
Editorial overview: An initiative toward Ebolavirus disease (EVD) free world: An edited special anti-infective issue on Ebola virus disease	22
Integrating single-cell transcriptomics and microcircuit computer modeling	22
Editorial Board	22
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside	22
Therapeutic approaches in different congenital myopathies	22
Photopharmacological approaches for dissecting potassium channel physiology	21
Treatment of severe alcoholic hepatitis: A systematic review	21
Very-low-calorie ketogenic diet: An alternative to a pharmacological approach to improve glycometabolic and gonadal profile in men with obesity	21
Drug development for the treatment of RyR1-related skeletal muscle diseases	21
Strategies to enhance anti-leukaemia immunotherapy	20
Autophagy in neuronal physiology and disease	19
Lipids and lipid regulators in intraocular pressure homeostasis	19
Oligonucleotide-based therapies for cystic fibrosis	19
Antihypertensive effect of soybean bioactive peptides: A review	19
Oncohistone-sculpted epigenetic mechanisms in pediatric brain cancer	19
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”	18
Nutraceuticals in mental diseases — Bridging the gap between traditional use and modern pharmacology	18
Host membrane proteins in the HIV-induced membrane fusion: Role in pathogenesis and therapeutic potential of autoantibodies	18
Organotypic human ex vivo models for coronavirus disease 2019 research and drug development	17
Non-alcoholic fatty liver disease: Current therapeutic options	17
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration	17
Photopharmacological control of cell signaling with photoswitchable lipids	17
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer	17
MicroRNA: A mediator of diet-induced cardiovascular protection	17
Functional role of the ER stress transducer IRE1α in CF airway epithelial inflammation	16
Adoptive cell therapy for solid tumors: Chimeric antigen receptor T cells and beyond	16
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway	16
Challenges in Formulating Transdermal Systems for Treating Chronic Skin Infections	16
Antibiotics, the microbiome and gastrointestinal cancers: A causal interference?	16
Editorial overview: COVID-19 therapy: From lung disease to systemic disorder	16
Purinergic signalling in graft-versus-host disease	16
Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction	16
Light-activated receptor tyrosine kinases: Designs and applications	15
Editorial Board	15
Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscle	15
AI-driven GPCR analysis, engineering, and targeting	15
Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies	15
Fluorescent chemigenetic actuators and indicators for use in living animals	15

CFTR RNA- and DNA-based therapies	15
NMR applications to GPCR recognition by peptide ligands	15
Targeting fibroblast-like synoviocytes in rheumatoid arthritis	15
Editorial overview: Introduction to the musculoskeletal section of current opinion in pharmacology	15
Effects of protein glycation and protective mechanisms against glycative stress	15
Novel approaches to CAR T cell target identification in acute myeloid leukemia	14
Targeting the endocannabinoid system for the management of low back pain	14
PRRT for higher-grade neuroendocrine neoplasms: What is still acceptable?	14
Towards eradication of HBV: Treatment approaches and status of clinical trials	14
Novel treatments for dry eye syndrome	14
The expanding role of split protein complementation in opsin-free optogenetics	14
Advances in tethered photopharmacology for precise optical control of signaling proteins	14
Immune dysfunction after spinal cord injury – A review of autonomic and neuroendocrine mechanisms	14
TMEM16A (ANO1) as a therapeutic target in cystic fibrosis	14