OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Pharmacology is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Targeting CD73 to augment cancer immunotherapy	79
The molecular link between oxidative stress, insulin resistance, and type 2 diabetes: A target for new therapies against cardiovascular diseases	55
Nanotechnology in pulmonary medicine	47
Alleviating tumor hypoxia with perfluorocarbon-based oxygen carriers	46
Gestational diabetes: Implications for fetal growth, intervention timing, and treatment options	45
Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus	44
Prospects for COPD treatment	44
Adipose tissue depot differences in adipokines and effects on skeletal and cardiac muscle	42
Targeting B cells for inflammatory bowel disease treatment: back to the future	37
The regulatory roles of dietary fibers on host health via gut microbiota-derived short chain fatty acids	36
Transforming targeted cancer therapy with PROTACs: A forward-looking perspective	36
Recent discoveries in HIV-1 reverse transcriptase inhibitors	34
Bile acid-activated receptors and the regulation of macrophages function in metabolic disorders	34
Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy	33
Targeting the A2AR in cancer; early lessons from the clinic	32
Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications	31
Gut microbiota and regulation of myokine-adipokine function	30
Myokines and adipokines in sarcopenia: understanding cross-talk between skeletal muscle and adipose tissue and the role of exercise	30
Targeting fibroblast-like synoviocytes in rheumatoid arthritis	30
A review of emerging neuroprotective and neuroregenerative therapies in traumatic spinal cord injury	30
Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies	29
Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistance	29
Antihypertensive effect of soybean bioactive peptides: A review	28
Exercise and browning of white adipose tissue – a translational perspective	26
Astrocytes as cellular mediators of cue reactivity in addiction	25

Glutamate receptors and metaplasticity in addiction	25
N-methyl-d-aspartate receptor function in neuronal and synaptic development and signaling	25
Current advances in the treatment of systemic sclerosis	25
Monitoring vedolizumab and ustekinumab drug levels in patients with inflammatory bowel disease: hype or hope?	25
Treatments for COVID-19: Lessons from 2020 and new therapeutic options	24
Chronotherapy of cardiac and vascular disease: timing medications to circadian rhythms to optimize treatment effects and outcomes	24
Non-nucleoside reverse transcriptase inhibitors (NNRTIs): a brief overview of clinically approved drugs and combination regimens	24
Circadian control of human cardiovascular function	24
Exercise as a drug for glucose management and prevention in type 2 diabetes mellitus	24
Treatment of early rheumatoid arthritis: Methotrexate and beyond	23
Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis	23
The role of the liver in the modulation of glucose and insulin in non alcoholic fatty liver disease and type 2 diabetes	23
Circadian influence on inflammatory response during cardiovascular disease	23
Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use disorder	22
The pleiotropic roles of autophagy in Alzheimer's disease: From pathophysiology to therapy	22
Renal protection with glucagon-like peptide-1 receptor agonists	22
Metabolic adaptations after bariatric surgery: adipokines, myokines and hepatokines	21
Disruption of energy utilization in diabetic cardiomyopathy; a mini review	21
Drug-resistance in rheumatoid arthritis: the role of p53 gene mutations, ABC family transporters and personal factors	20
Anti-inflammatory glucocorticoid action: genomic insights and emerging concepts	20
Current state of CFTR modulators for treatment of Cystic Fibrosis	20
Applications of chemogenetics in non-human primates	20
Alpha1-antitrypsin deficiency: New therapies on the horizon	20
The role of faecal microbiota transplantation in the treatment of inflammatory bowel disease	20
Rethinking the clinical management of volumetric muscle loss in patients with spinal cord injury: Synergy among nutritional supplementation, pharmacotherapy, and rehabilitation	20
Does probiotics work for bacterial vaginosis and vulvovaginal candidiasis	19
Adoptive cell therapy for solid tumors: Chimeric antigen receptor T cells and beyond	19
Role of the endocannabinoid system in the regulation of the skeletal muscle response to exercise	19
Photopharmacological control of cell signaling with photoswitchable lipids	19
Current pharmacological intervention and development of targeting IVIG resistance in Kawasaki disease	18
Environmental enrichment-inspired pharmacological tools for the treatment of addiction	18
MicroRNAs as mediators of drug resistance mechanisms	18
Testosterone therapy for prevention and reversal of type 2 diabetes in men with low testosterone	18
TMEM16A (ANO1) as a therapeutic target in cystic fibrosis	18
Intersection of immunometabolism and immunosenescence during aging	18
Updated pharmacological effects of Lonicerae japonicae flos, with a focus on its potential efficacy on coronavirus disease–2019 (COVID-19)	18
Effects of functional electrical stimulation on muscle health after spinal cord injury	17
Integrating the roles of liver X receptors in inflammation and infection: mechanisms and outcomes	17
The changing landscape of the cystic fibrosis lung environment: From the perspective of Pseudomonas aeruginosa	17
Optical control of Class A G protein-coupled receptors with photoswitchable ligands	17
Cost-effectiveness of therapeutic drug monitoring in inflammatory bowel disease	17
New drugs in the pipeline for the treatment of inflammatory bowel diseases: what is coming?	17
Immunogenicity, breakthrough infection, and underlying disease flare after SARS-CoV-2 vaccination among individuals with systemic autoimmune rheumatic diseases	16
The 2013–2016 Ebola virus disease outbreak in West Africa	16
Prospects for severe asthma treatment	16
Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration	16
Lipid deposition and metaflammation in diabetic kidney disease	15
The hypodopaminergic state ten years after: transcranial magnetic stimulation as a tool to test the dopamine hypothesis of drug addiction	15
Lynx1 prototoxins: critical accessory proteins of neuronal nicotinic acetylcholine receptors	15
Hormonal drugs for the treatment of endometriosis	15

Probing function in 3D neuronal cultures: A survey of 3D multielectrode array advances	15
Role of intestinal glucose absorption in glucose tolerance	15
Elexacaftor–tezacaftor–ivacaftor: The new paradigm to treat people with cystic fibrosis with at least one p.Phe508del mutation	15
The e-psychonaut drugs’ psychopharmacology	14
Immune dysfunction after spinal cord injury – A review of autonomic and neuroendocrine mechanisms	14
Genetic risk scores and personalization of care in fatty liver disease	14
Oxygenation and A2AR blockade to eliminate hypoxia/HIF-1α-adenosinergic immunosuppressive axis and improve cancer immunotherapy	14
Microbiota-gut-brain axis: A novel potential target of ketogenic diet for epilepsy	14
Pharmacological modulation of GABAA receptors	14
Mechanisms underlying N3-PUFA regulation of white adipose tissue endocrine function	14
Lipid metabolism as a mechanism of immunomodulation in macrophages: the role of liver X receptors	14
Regulation of adipose tissue and skeletal muscle substrate metabolism by the stomach-derived hormone, ghrelin	14
RNAi therapeutics: an antiviral strategy for human infections	14
Non-alcoholic fatty liver disease: Current therapeutic options	14
Metabokines in the regulation of systemic energy metabolism	13
Stress, kisspeptin, and functional hypothalamic amenorrhea	13
Recent insights into astrocytes as therapeutic targets for demyelinating diseases	13
Targeting drug memory reconsolidation: a neural analysis	13
Design strategies for long-acting anti-HIV pharmaceuticals	13
Evolving understanding of cardiovascular protection by SGLT2 inhibitors: focus on renal protection, myocardial effects, uric acid, and magnesium balance	13
Therapeutics development for Ebola virus disease: A recent scenario	12
Molecular routes to sarcopenia and biomarker development: per aspera ad astra	12
Tackling inflammation in atherosclerosis: Are we there yet and what lies beyond?	12
Recent advances in emerging PCOS therapies	12
Highland mate: Edible and functional foods in traditional medicine for the prevention and treatment of hypoxia-related symptoms	12
Contribution of the bone marrow stromal cells in mediating drug resistance in hematopoietic tumors	12
Pharmacology of pannexin channels	12
Targeting cellular senescence as a new approach to chronic obstructive pulmonary disease therapy	12
Targeting cellular senescence as a novel treatment for osteoarthritis	12
Promising therapeutic approaches in pulmonary arterial hypertension	12
Recent developments and strategies of Ebola virus vaccines	12