OOIR: Observatory of International Research

Papers

(The TQCC of Current Opinion in Pharmacology is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Native botulinum toxin type A vs. redesigned botulinum toxins in pain: What did we learn so far?	108
Editorial Board	100
Therapeutic hurdles in acute myeloid leukemia: Leukemic stem cells, inflammation and immune dysfunction	92
From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling	74
Lipid raft disruption as an opportunity for peripheral analgesia	64
The role of extracellular ATP in homeostatic immune cell migration	59
The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies	51
Recent advances in emerging PCOS therapies	50
Gastrointestinal issue: Advances in gastrointestinal oncology	47
Editorial Board	43
Optofluidic neural interfaces for in vivo photopharmacology	40
Technological advancements to study cellular signaling pathways in inherited retinal degenerative diseases	40
Photo-isomerizable tweezers to probe ionotropic receptor mechanisms	37
Considerations for individualized first-line systemic treatment in advanced hepatocellular carcinoma	36
Pancreatic alpha cells and glucagon secretion: Novel functions and targets in glucose homeostasis	35
Optic nerve regeneration: Potential treatment approaches	33
Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration	33
Editorial overview: Special issue on “Rheumatology: Therapeutic advances for autoimmune and musculoskeletal diseases”	33
Advanced microneedle arrays for transdermal antibiotic delivery	33
Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistance	33
A review of emerging neuroprotective and neuroregenerative therapies in traumatic spinal cord injury	30
Three-dimensional culture models to study glioblastoma — current trends and future perspectives	30
Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus	29
Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis	29
Editorial Board	29

Effects of functional electrical stimulation on muscle health after spinal cord injury	28
Allogeneic double-negative T-cell therapy for acute myeloid leukemia	27
Therapeutic approaches in different congenital myopathies	26
Current state of CFTR modulators for treatment of Cystic Fibrosis	26
Editorial Board	26
Animal models of cystic fibrosis in the era of highly effective modulator therapies	26
Plant-based vaccine research development against viral diseases with emphasis on Ebola virus disease: A review study	26
Integrating single-cell transcriptomics and microcircuit computer modeling	25
Gene therapies for RyR1-related myopathies	24
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside	24
Editorial overview: An initiative toward Ebolavirus disease (EVD) free world: An edited special anti-infective issue on Ebola virus disease	24
Next-gen therapeutics to spare and expand beta-cell mass	23
Oligonucleotide-based therapies for cystic fibrosis	23
Lipids and lipid regulators in intraocular pressure homeostasis	22
Photopharmacological approaches for dissecting potassium channel physiology	21
Oncohistone-sculpted epigenetic mechanisms in pediatric brain cancer	21
Very-low-calorie ketogenic diet: An alternative to a pharmacological approach to improve glycometabolic and gonadal profile in men with obesity	21
Strategies to enhance anti-leukaemia immunotherapy	21
Antihypertensive effect of soybean bioactive peptides: A review	20
Host membrane proteins in the HIV-induced membrane fusion: Role in pathogenesis and therapeutic potential of autoantibodies	20
Treatment of severe alcoholic hepatitis: A systematic review	20
Drug development for the treatment of RyR1-related skeletal muscle diseases	20
Autophagy in neuronal physiology and disease	20
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration	20
Non-alcoholic fatty liver disease: Current therapeutic options	19
Nutraceuticals in mental diseases — Bridging the gap between traditional use and modern pharmacology	19
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer	19
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”	19
Photopharmacological control of cell signaling with photoswitchable lipids	18
Editorial overview: COVID-19 therapy: From lung disease to systemic disorder	18
Functional role of the ER stress transducer IRE1α in CF airway epithelial inflammation	18
MicroRNA: A mediator of diet-induced cardiovascular protection	18
Antibiotics, the microbiome and gastrointestinal cancers: A causal interference?	17
Light-activated receptor tyrosine kinases: Designs and applications	17
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway	17
Purinergic signalling in graft-versus-host disease	17
Challenges in formulating transdermal systems for treating chronic skin infections	17
Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction	17
Editorial Board	16
Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies	16
CFTR RNA- and DNA-based therapies	16
Fluorescent chemigenetic actuators and indicators for use in living animals	16
PRRT for higher-grade neuroendocrine neoplasms: What is still acceptable?	16
Targeting fibroblast-like synoviocytes in rheumatoid arthritis	16
Editorial overview: Introduction to the musculoskeletal section of current opinion in pharmacology	16
AI-driven GPCR analysis, engineering, and targeting	16
Effects of protein glycation and protective mechanisms against glycative stress	15
NMR applications to GPCR recognition by peptide ligands	15
Advances in tethered photopharmacology for precise optical control of signaling proteins	15
Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscle	15

Novel approaches to CAR T cell target identification in acute myeloid leukemia	15
TMEM16A (ANO1) as a therapeutic target in cystic fibrosis	15
Targeting the endocannabinoid system for the management of low back pain	15
The expanding role of split protein complementation in opsin-free optogenetics	15
Immune dysfunction after spinal cord injury – A review of autonomic and neuroendocrine mechanisms	15
Towards eradication of HBV: Treatment approaches and status of clinical trials	15