Trends in Immunology

Article	Citations
Advisory Board and Contents	387
Metabolic and stress response adaptations in T cells to fever and physiological heat	330
Novel insights and recent progress in osteoimmunology	312
Advisory Board and Contents	280
Subscription and Copyright Information	152
Advisory Board and Contents	152
DNA flexibility can shape the preferential hypermutation of antibody genes	147
Unleashing dendritic cell-mediated tumor clearance by targeting Bcl-2	139
Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?	122
On tending sprouts: empowering emerging immunologists in Latin America	122
Emerging roles of Dectin-1 in noninfectious settings and in the CNS	118
Dietary fibers affecting gastrointestinal immunity	116
Contribution of gut-derived T cells to extraintestinal autoimmune diseases	105
Tensor-based insights into systems immunity and infectious disease	91
Lymph node stromal cells: subsets and functions in health and disease	89
Innate immunity: the bacterial connection	89
Ragulator-Rag and ROS TORment gasdermin D pore formation	88
Carbohydrates in allergy: from disease to novel immunotherapies	77
Subscription and Copyright Information	76
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections	75
EmBmem: will the real memory B cell please stand up?	73
Risk factors of cytokine release syndrome: stress, catecholamines, and beyond	73
Loss of ARID1A ‘loops’ in STING	67
DNA at the center of mammalian innate immune recognition of bacterial biofilms	66
BCR signaling in germinal center B cell selection	65

Inflammatory and immune etiology of type 2 diabetes	63
Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine	59
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis	58
Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics	57
The tumor niche can reprogram long-lived protumorigenic neutrophils	57
High endothelial venules as potential gateways for therapeutics	55
Oxidative battles in tuberculosis: walking the ferroptotic tightrope	55
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology	54
Unanticipated specificity in effector-triggered immunity	52
Genotype–phenotype landscapes for immune–pathogen coevolution	51
The translational potential of studying bat immunity	51
Context-dependent regulation of follicular helper T cell survival	50
The five senses of immunity	49
Subscription and Copyright Information	48
Leveraging community engagement to shape biomedical research priorities	47
Targeting Th17 cells in HIV-1 remission/cure interventions	46
Microglia as integrators of brain-associated molecular patterns	45
Cytosolic delivery of innate immune agonists	45
Agents of cancer immunosurveillance: HSPs and dsDNA	44
Tumor microenvironment metabolites directing T cell differentiation and function	44
Maternal inflammation and its ramifications on fetal neurodevelopment	43
Subscription and Copyright Information	42
Advisory Board and Contents	42
Subscription and Copyright Information	42
Subscription and Copyright Information	42
Subscription and Copyright Information	41
Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens	40
Intracellular C1q – an unexpected player in neuronal proteostasis	40
B cells masquerade as dendritic cells	40
Astrocytes ACLYmate to chronic neuroinflammation	40
Neuroimmune cleanup crews in brain injury	39
Antigen presentation by MHC-E: a putative target for vaccination?	39
Immune evasion in ovarian cancer: implications for immunotherapy and emerging treatments	38
Bridging anatomical gaps between brain and immune system	38
Original antigenic sin: not so sinful after all	38
Subscription and Copyright Information	37
Natural resistance against infections: focus on COVID-19	37
Monoallelic expression in human immune cells: linking genotype to phenotype	36
TLR9 triggers MyD88-independent anti-inflammatory signaling in lupus	35
The complex immunological role of Helicobacter in modulating cancer	35
Lymphoid tissue on the mind	34
Spiking SARS-CoV-2 antiviral immunity in the respiratory tract	34
Old macrophages lose their (circadian) rhythm	33
Calreticulin surface presentation can promote quality control of hematopoietic stem cells	33
Transcription factor-driven regulation of ILC1 and ILC3	33
Understanding mast cell heterogeneity at single cell resolution	32
Emerging roles for tRNAs in hematopoiesis and hematological malignancies	32
LNCing RNA to immunity	31
Advisory Board and Contents	31
Advisory Board and Contents	31

Advisory Board and Contents	30
Protists protecting food tolerance	28
Signaling is the pathway to macrophage function	28
Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers	27
Targeting the metabolism of tumor-infiltrating regulatory T cells	27
Chimeric antigen receptor Treg therapy in transplantation	27
Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities	27
Advisory Board and Contents	27
Putative role of STING-mitochondria associated membrane crosstalk in immunity	27
Advisory Board and Contents	27
Harder, better, faster, stronger: biochemistry and biophysics in the immunosurveillance concert	25
Protect, repair, rewire, and defend	25
The predictive power of systems immunology	25
Sensory nerves unlock the TOLL-7 gate for cancer spread	25
Multiple sclerosis: role of meningeal lymphoid aggregates in progression independent of relapse activity	25
Subscription and Copyright Information	25
Immune-featured decidual stromal cells: pregnancy's multitasking superstars	25
Immunotherapy response-associated Akkermansia: canary in a coal mine?	25
TCR-sequencing in cancer and autoimmunity: barcodes and beyond	24
New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies	24
Sensory neuronal control of skin barrier immunity	24
Overcoming gender bias in STEM	24
Regulation and impact of tumor-specific CD4+ T cells in cancer and immunotherapy	23
Th17 cells: from gut homeostasis to CNS pathogenesis	23
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy	22
Lymph node fibroblast-produced extracellular matrix shapes immune function	22
BCG vaccination induces cross-protective immunity against pathogenic microorganisms	22
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The diversity of cGLR receptors: shedding new light on innate immunity	21
Life and death of tolerogenic dendritic cells	21
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases	21
B cell phylogenetics in the single cell era	21
COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle	21
Feeding the wrath with myelin	21
Partners and guardians of the nervous and immune systems	21
CD8+ Tregs kill pathogenic cells to avert autoimmunity	21
How do autoimmune CD4+ T cells handle exhaustion?	21
SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences	20
The extracellular matrix and immunity: breaking the old barrier in cancer	20
Inflammasome diversity: exploring novel frontiers in the innate immune response	20
RORγt protein modifications and IL-17-mediated inflammation	20
cGAS-like receptors: back to the future	19
Finding your niche: immune evasion in quiescent tumor reservoirs	19
Early clues regarding the pathogenesis of long-COVID	19
Why are there so few (or so many) circulating coronaviruses?	19
Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment	19
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis	18
Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions	17
Advisory Board and Contents	17
Human neutrophil kinetics: a call to revisit old evidence	17
Subscription and Copyright Information	17
Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunity	17
ICOS-play: dressing T cells for residency	17
Macrophage states: there's a method in the madness	16
RNA circuits and RNA-binding proteins in T cells	16
Restriction factors regulating human herpesvirus infections	16
Breaking down IgA: Tomasiella immunophila enlightens microbiome–immune interactions	16
CD4+ T cells that help B cells – a proposal for uniform nomenclature	16
Exhausted CD8+ T cells face a developmental fork in the road	16
Inflammasomopathies: mechanisms and disease signatures	16
Physiological role of cytokines in the regulation of mammalian metabolism	15
A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development	15
Lipid regulation of NLRP3 inflammasome activity through organelle stress	15
Advisory Board and Contents	15
Turning cold tumors hot: from molecular mechanisms to clinical applications	15
Unraveling B cell trajectories at single cell resolution	15
Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine	14
The meningeal lymphatics: regulators of Aβ immunotherapy?	14
Baby’s skin bacteria: first impressions are long-lasting	14
Prenatal inflammation shapes microglial immune response into adulthood	14
Channel plan: control of adaptive immune responses by pannexins	14
New insights into transcription elongation control of HIV-1 latency and rebound	14
T cell TET2 disruption cuts the breaks on antitumor CAR T cell therapy	14
Cancer germline antigens and tumor-agnostic CD8+ T cell evasion	14
Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?	14
Advisory Board and Contents	13
Cytokine-skewed Tfh cells: functional consequences for B cell help	13
Monoclonal antibodies lock down SARS-CoV-2 spike	13
Zebrafish: an underutilized tool for discovery in host–microbe interactions	13
Subscription and Copyright Information	13

Unleashing TNF cytotoxicity to enhance cancer immunotherapy	13
Subscription and Copyright Information	12
Advisory Board and Contents	12
Humans pIKK-up NLRP3 to skip NEK7	12
Advisory Board and Contents	12
Towards a quantitative theory of tolerance	12
Trust your gut: an early life lesson for T cells	12
Affinity-independent plasma cell differentiation in germinal centers	12
Approaches for studying neuroimmune interactions in Alzheimer’s disease	11
Uniting innate and adaptive immunity in glioblastoma; an α-CTLA-4 quest	11
Enhancing tumor immunity via in vivo cDC1 reprogramming	11
SARS-CoV-2 vaccination washes away original antigenic sin	11
Introducing the 'Significance' box in Trends in Immunology articles	11
Regional specialization within the mammalian respiratory immune system	11
Malaria: influence of Anopheles mosquito saliva on Plasmodium infection	11
Locus architecture and RAG scanning determine antibody diversity	11
Subscription and Copyright Information	10
Microglia replacement: from monocytic origin to therapy	10
Developing cultural humility in immunology and STEMM mentoring	10
Inflammatory and immune effects on tumor progression	10
Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond	10
Subscription and Copyright Information	10
Ghrelin and leptin regulating wound healing	10
Aching to defend: spleen innervation drives humoral immunity	10
Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death	10
Shaped by the epithelium – postnatal immune mechanisms of oral homeostasis	10
Host immunity and cellular responses to bacterial outer membrane vesicles	10
OTULIN in NF-κB signaling, cell death, and disease	10
Using TCR-CAR dual signaling for precise cancer targeting	10
Mutagenic repair during antibody diversification: emerging insights	9
Gutsy sensations modulate intestinal disease	9
Memory B cell diversity: insights for optimized vaccine design	9
Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks	9
Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus	9
Deciphering SARS-CoV-2 evolution under antibody immune pressure	9
Genetic conflicts and the origin of self/nonself-discrimination in the vertebrate immune system	9
Advisory Board and Contents	9
Pseudomonas aeruginosa: a pathogen making itself at home	9
Multiscale geometric and topological analyses for characterizing and predicting immune responses from single cell data	9
Microglia pack a toolbox for life	9
The Vibrio cholerae maneuver	8
Subscription and Copyright Information	8
Targeting immune evasion in hepatocellular carcinoma-initiating cells	8
ADAR1 and ZBP1 in innate immunity, cell death, and disease	8
Over but not gone: lingering epigenetic effects of COVID-19	8
Structure-based mechanisms of 2′3′-cGAMP intercellular transport in the cGAS–STING immune pathway	8
Embryonic microglia maintain the brain's cortical fault lines	8
Advisory Board and Contents	8
Emerging mechanisms of immunocoagulation in sepsis and septic shock	8
Lung tumor immunity: redirecting macrophages through infection-induced inflammation	7
The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder	7
C3-targeted therapy in periodontal disease: moving closer to the clinic	7
Helper ILCs in the human hematopoietic system	7
Recombinant snake antivenoms get closer to the clinic	7
The putative contribution of cellular senescence to driving tauopathies	7
Sodium and its manifold impact on our immune system	7
Immunomodulatory impact of α-fetoprotein	6
Allogeneic hematopoietic stem cell transplantation: lessons learned by a molecular immunologist/transplant patient	6
Decoding microglial functions in Alzheimer’s disease: insights from human models	6
The heightened importance of the microbiome in cancer immunotherapy	6
Why do central nervous system barriers host a diverse immune landscape?	6
Advisory Board and Contents	6
Tracking tumor-specific CD8+ T cell responses	6
Tissue-specific differentiation of CD8+ resident memory T cells	6
Leveraging deep learning to improve vaccine design	6
Advisory Board and Contents	6
Oxidative stress, malaria, sickle cell disease, and innate immunity	6
Towards decoding the space-time continuum of pregnancy	6
Diet and immune response: how today’s plate shapes tomorrow’s health	6
Macrophage immunotherapy: overcoming impediments to realize promise	5
Complement(ing) long-COVID thromboinflammation and pathogenesis	5
Subscription and Copyright Information	5
Deconstructing iNKT cell development at single-cell resolution	5
Boosting peripheral immunity to fight neurodegeneration in the brain	5
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Approaches for studying human macrophages	5
NF-κB: blending metabolism, immunity, and inflammation	5
Advisory Board and Contents	5
Modeling human immune responses to vaccination in vitro	5
The cancer cell-derived extracellular vesicle glycocode in immunoevasion	4
The extracellular matrix in solid tumor immunotherapy	4
Modulation of host immunity by sensory neurons	4
Keeping T cell memories in mind	4
DNA repair and antibody diversification: the 53BP1 paradigm	4
Pathways and mechanisms of CD4+CD8αα+ intraepithelial T cell development	4
Emerging roles of astrocytes as immune effectors in the central nervous system	4
Subscription and Copyright Information	4
Liquid–liquid phase separation in innate immunity	4
The unusual metabolism of germinal center B cells	4
Splicing dysregulation in human hematologic malignancies: beyond splicing mutations	4
Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond	4
Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis	4
Sterols in asthma	4
Analyzing the unperturbed HIV-1 T cell reservoir	4