Trends in Immunology

Article	Citations
Advisory Board and Contents	455
Advisory Board and Contents	380
Subscription and Copyright Information	370
Advisory Board and Contents	196
Tensor-based insights into systems immunity and infectious disease	178
Novel insights and recent progress in osteoimmunology	154
Metabolic and stress response adaptations in T cells to fever and physiological heat	149
‘Smelling’ lipid cues: chemosensory receptors tune tumor-associated macrophage behavior	141
Innate immunity: the bacterial connection	131
DNA flexibility can shape the preferential hypermutation of antibody genes	120
Emerging roles of Dectin-1 in noninfectious settings and in the CNS	120
Dietary fibers affecting gastrointestinal immunity	113
On tending sprouts: empowering emerging immunologists in Latin America	93
Unleashing dendritic cell-mediated tumor clearance by targeting Bcl-2	89
Lymph node stromal cells: subsets and functions in health and disease	84
Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?	84
Ragulator-Rag and ROS TORment gasdermin D pore formation	76
Contribution of gut-derived T cells to extraintestinal autoimmune diseases	72
Subscription and Copyright Information	70
DNA at the center of mammalian innate immune recognition of bacterial biofilms	69
Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine	68
Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy?	64
The tumor niche can reprogram long-lived protumorigenic neutrophils	61
BCR signaling in germinal center B cell selection	61
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis	59

Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections	58
EmBmem: will the real memory B cell please stand up?	58
Loss of ARID1A ‘loops’ in STING	58
Oxidative battles in tuberculosis: walking the ferroptotic tightrope	56
Targeting WSTF degradation to resolve chronic inflammation	56
Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics	55
Inflammatory and immune etiology of type 2 diabetes	52
Risk factors of cytokine release syndrome: stress, catecholamines, and beyond	51
Context-dependent regulation of follicular helper T cell survival	48
The five senses of immunity	48
Agents of cancer immunosurveillance: HSPs and dsDNA	47
Advisory Board and Contents	47
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology	46
Infusion of neutralization into Lassa vaccine design	46
Subscription and Copyright Information	46
Unanticipated specificity in effector-triggered immunity	44
Targeting Th17 cells in HIV-1 remission/cure interventions	44
Leveraging community engagement to shape biomedical research priorities	44
Microglia as integrators of brain-associated molecular patterns	43
High endothelial venules as potential gateways for therapeutics	43
Tumor microenvironment metabolites directing T cell differentiation and function	42
Genotype–phenotype landscapes for immune–pathogen coevolution	42
The translational potential of studying bat immunity	42
Cytosolic delivery of innate immune agonists	41
Subscription and Copyright Information	41
Maternal inflammation and its ramifications on fetal neurodevelopment	41
Subscription and Copyright Information	40
Subscription and Copyright Information	37
Subscription and Copyright Information	37
Advisory Board and Contents	36
Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens	35
Original antigenic sin: not so sinful after all	34
Astrocytes ACLYmate to chronic neuroinflammation	34
Mitochondrial dysfunction in myeloid cells: a central deficit in autoimmune diseases	34
B cells masquerade as dendritic cells	33
Bridging anatomical gaps between brain and immune system	33
Natural resistance against infections: focus on COVID-19	33
Intracellular C1q – an unexpected player in neuronal proteostasis	32
Balancing IL-17–mediated protection and IFN-γ–driven pathology at mucocutaneous barriers	32
Antigen presentation by MHC-E: a putative target for vaccination?	32
Immune evasion in ovarian cancer: implications for immunotherapy and emerging treatments	32
Subscription and Copyright Information	31
The complex immunological role of Helicobacter in modulating cancer	31
Monoallelic expression in human immune cells: linking genotype to phenotype	31
Emerging roles for tRNAs in hematopoiesis and hematological malignancies	30
Lymphoid tissue on the mind	30
Old macrophages lose their (circadian) rhythm	29
TLR9 triggers MyD88-independent anti-inflammatory signaling in lupus	29
Calreticulin surface presentation can promote quality control of hematopoietic stem cells	29
Spiking SARS-CoV-2 antiviral immunity in the respiratory tract	28

Transcription factor-driven regulation of ILC1 and ILC3	28
LNCing RNA to immunity	28
Signaling is the pathway to macrophage function	27
Advisory Board and Contents	27
Gut microbiota–host post-translational modification axis in immunometabolic diseases	27
Advisory Board and Contents	27
Advisory Board and Contents	27
Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities	26
Exploring mucosal immune development and function in utero	26
Putative role of STING-mitochondria associated membrane crosstalk in immunity	26
Protists protecting food tolerance	26
Subscription and Copyright Information	26
Advisory Board and Contents	25
Chimeric antigen receptor Treg therapy in transplantation	25
Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers	25
Advisory Board and Contents	25
Targeting the metabolism of tumor-infiltrating regulatory T cells	25
Subscription and Copyright Information	24
Sensory nerves unlock the TOLL-7 gate for cancer spread	24
New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies	23
Immunotherapy response-associated Akkermansia: canary in a coal mine?	23
Subscription and Copyright Information	23
Overcoming gender bias in STEM	23
Th17 cells: from gut homeostasis to CNS pathogenesis	23
The predictive power of systems immunology	23
Harder, better, faster, stronger: biochemistry and biophysics in the immunosurveillance concert	23
BCG vaccination induces cross-protective immunity against pathogenic microorganisms	22
Protect, repair, rewire, and defend	22
Multiple sclerosis: role of meningeal lymphoid aggregates in progression independent of relapse activity	22
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy	22
Immune-featured decidual stromal cells: pregnancy's multitasking superstars	22
TCR-sequencing in cancer and autoimmunity: barcodes and beyond	21
Sensory neuronal control of skin barrier immunity	21
Regulation and impact of tumor-specific CD4+ T cells in cancer and immunotherapy	21
Subscription and Copyright Information	20
How do autoimmune CD4+ T cells handle exhaustion?	20
Inflammasome diversity: exploring novel frontiers in the innate immune response	19
Partners and guardians of the nervous and immune systems	18
CD8+ Tregs kill pathogenic cells to avert autoimmunity	18
Life and death of tolerogenic dendritic cells	18
The diversity of cGLR receptors: shedding new light on innate immunity	18
B cell phylogenetics in the single cell era	18
Feeding the wrath with myelin	18
Development of a circadian immune system	18
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases	17
RORγt protein modifications and IL-17-mediated inflammation	17
COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle	17
Lymph node fibroblast-produced extracellular matrix shapes immune function	17
SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences	17
Repurposing of old drugs for unleashing innate immunity	17
Early clues regarding the pathogenesis of long-COVID	16
The extracellular matrix and immunity: breaking the old barrier in cancer	16
Human neutrophil kinetics: a call to revisit old evidence	16
Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment	16
Finding your niche: immune evasion in quiescent tumor reservoirs	16
News from the T cell trogocytosis front	16
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis	16
Advisory Board and Contents	15
Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunity	15
Breaking down IgA: Tomasiella immunophila enlightens microbiome–immune interactions	15
cGAS-like receptors: back to the future	15
RNA circuits and RNA-binding proteins in T cells	15
ICOS-play: dressing T cells for residency	15
Macrophage states: there's a method in the madness	14
Inflammasomopathies: mechanisms and disease signatures	14
Unraveling B cell trajectories at single cell resolution	14
Restriction factors regulating human herpesvirus infections	14
Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice	14
Exhausted CD8+ T cells face a developmental fork in the road	14
Molecular mimicry as a driver of T cell-mediated tumour immunity	14
Neuro–immune crosstalk: focus on innate lymphoid cells	14
Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine	13
T cell TET2 disruption cuts the breaks on antitumor CAR T cell therapy	13
Advisory Board and Contents	13
The T cell subsetting challenge	13
Channel plan: control of adaptive immune responses by pannexins	13
Cancer germline antigens and tumor-agnostic CD8+ T cell evasion	13
Turning cold tumors hot: from molecular mechanisms to clinical applications	13
The meningeal lymphatics: regulators of Aβ immunotherapy?	13
Unleashing TNF cytotoxicity to enhance cancer immunotherapy	13

A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development	13
Physiological role of cytokines in the regulation of mammalian metabolism	13
Prenatal inflammation shapes microglial immune response into adulthood	12
Monoclonal antibodies lock down SARS-CoV-2 spike	12
Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?	12
Baby’s skin bacteria: first impressions are long-lasting	12
Advisory Board and Contents	12
Zebrafish: an underutilized tool for discovery in host–microbe interactions	12
New insights into transcription elongation control of HIV-1 latency and rebound	12
Subscription and Copyright Information	12
Ghrelin and leptin regulating wound healing	11
Introducing the 'Significance' box in Trends in Immunology articles	11
Advisory Board and Contents	11
Regional specialization within the mammalian respiratory immune system	11
Malaria: influence of Anopheles mosquito saliva on Plasmodium infection	11
Uniting innate and adaptive immunity in glioblastoma; an α-CTLA-4 quest	11
Cryptic but critical: non-canonical antigens in cancer immunotherapy	11
Inflammatory and immune effects on tumor progression	11
Advisory Board and Contents	11
Locus architecture and RAG scanning determine antibody diversity	10
Using TCR-CAR dual signaling for precise cancer targeting	10
Humans pIKK-up NLRP3 to skip NEK7	10
Microglia replacement: from monocytic origin to therapy	10
Trust your gut: an early life lesson for T cells	10
Towards a quantitative theory of tolerance	10
Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond	10
Approaches for studying neuroimmune interactions in Alzheimer’s disease	9
SARS-CoV-2 vaccination washes away original antigenic sin	9
Affinity-independent plasma cell differentiation in germinal centers	9
Aching to defend: spleen innervation drives humoral immunity	9
Host immunity and cellular responses to bacterial outer membrane vesicles	9
Enhancing tumor immunity via in vivo cDC1 reprogramming	9
Developing cultural humility in immunology and STEMM mentoring	9
Subscription and Copyright Information	9
Subscription and Copyright Information	8
Mutagenic repair during antibody diversification: emerging insights	8
Deciphering SARS-CoV-2 evolution under antibody immune pressure	8
Structure-based mechanisms of 2′3′-cGAMP intercellular transport in the cGAS–STING immune pathway	8
Advisory Board and Contents	8
Gutsy sensations modulate intestinal disease	8
Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death	8
Multiscale geometric and topological analyses for characterizing and predicting immune responses from single cell data	8
Genetic conflicts and the origin of self/nonself-discrimination in the vertebrate immune system	8
Targeting immune evasion in hepatocellular carcinoma-initiating cells	8
Pseudomonas aeruginosa: a pathogen making itself at home	8
Enlightening Per2-suasive role of neutrophils in antibacterial immunity	8
Microglia pack a toolbox for life	7
Subscription and Copyright Information	7
ADAR1 and ZBP1 in innate immunity, cell death, and disease	7
Advisory Board and Contents	7
Memory B cell diversity: insights for optimized vaccine design	7
The Vibrio cholerae maneuver	7
Embryonic microglia maintain the brain's cortical fault lines	7
Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus	7
Immunomodulatory impact of α-fetoprotein	6
C3-targeted therapy in periodontal disease: moving closer to the clinic	6
Recombinant snake antivenoms get closer to the clinic	6
Tracking tumor-specific CD8+ T cell responses	6
The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder	6
Transcriptional control of natural killer cell antitumor activity	6
The putative contribution of cellular senescence to driving tauopathies	6
Oxidative stress, malaria, sickle cell disease, and innate immunity	6
Lung tumor immunity: redirecting macrophages through infection-induced inflammation	6
Over but not gone: lingering epigenetic effects of COVID-19	6
Helper ILCs in the human hematopoietic system	6
Allogeneic hematopoietic stem cell transplantation: lessons learned by a molecular immunologist/transplant patient	6
Diet and immune response: how today’s plate shapes tomorrow’s health	5
Tissue-specific differentiation of CD8+ resident memory T cells	5
Complement(ing) long-COVID thromboinflammation and pathogenesis	5
The heightened importance of the microbiome in cancer immunotherapy	5
Advisory Board and Contents	5
Leveraging deep learning to improve vaccine design	5
Advisory Board and Contents	5
Decoding microglial functions in Alzheimer’s disease: insights from human models	5
Why do central nervous system barriers host a diverse immune landscape?	5
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Modeling human immune responses to vaccination in vitro	5
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Boosting peripheral immunity to fight neurodegeneration in the brain	5
Towards decoding the space-time continuum of pregnancy	5
Approaches for studying human macrophages	5
Macrophage immunotherapy: overcoming impediments to realize promise	5
NF-κB: blending metabolism, immunity, and inflammation	5
On developmental programming of the immune system	5
Deconstructing iNKT cell development at single-cell resolution	5
Emerging roles of astrocytes as immune effectors in the central nervous system	4
Single B cell technologies for monoclonal antibody discovery	4
DNA repair and antibody diversification: the 53BP1 paradigm	4
Mutant ARID1A: igniting cancer immunotherapy	4
Modulation of host immunity by sensory neurons	4
Sterols in asthma	4
Liquid–liquid phase separation in innate immunity	4
The unusual metabolism of germinal center B cells	4
Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond	4
Keeping T cell memories in mind	4