Trends in Immunology

Article	Citations
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DNA flexibility can shape the preferential hypermutation of antibody genes	326
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On tending sprouts: empowering emerging immunologists in Latin America	209
Advisory Board and Contents	148
Advisory Board and Contents	145
Advisory Board and Contents	135
Unleashing dendritic cell-mediated tumor clearance by targeting Bcl-2	121
Two models, one question: how does respiratory syncytial virus cause asthma?	115
Experimental immunologists in the era of artificial intelligence	106
Tensor-based insights into systems immunity and infectious disease	101
Contribution of gut-derived T cells to extraintestinal autoimmune diseases	91
‘Smelling’ lipid cues: chemosensory receptors tune tumor-associated macrophage behavior	89
Dietary fibers affecting gastrointestinal immunity	87
Innate immunity: the bacterial connection	85
Novel insights and recent progress in osteoimmunology	85
Metabolic and stress response adaptations in T cells to fever and physiological heat	80
Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?	77
Loss of ARID1A ‘loops’ in STING	71
Beyond the innate immune system: rethinking inflammasomes in multiple sclerosis	70
EmBmem: will the real memory B cell please stand up?	69
Subscription and Copyright Information	62
Cell-intrinsic CD4 T cell tolerance: a new frontier in therapy?	61
Risk factors of cytokine release syndrome: stress, catecholamines, and beyond	60
Targeting WSTF degradation to resolve chronic inflammation	59

Parental leave in immunology—3	57
The tumor niche can reprogram long-lived protumorigenic neutrophils	57
DNA at the center of mammalian innate immune recognition of bacterial biofilms	56
BCR signaling in germinal center B cell selection	54
Inflammatory and immune etiology of type 2 diabetes	54
KLHL6: a proteostatic guardian against T-cell exhaustion	52
Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics	51
Oxidative battles in tuberculosis: walking the ferroptotic tightrope	49
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections	49
Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis	49
Advisory Board and Contents	48
SenSpots: when B cells age in place	48
Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine	48
TGF-β: A master regulator of tissue-resident macrophage identity and function	48
Cytokine specificity in macrophages: JAK-STAT and beyond	46
Microglia in systemic neuroimmune communication: functions beyond phagocytosis	44
Beyond the bench: teaching grant writing in immunotherapy training	44
Infusion of neutralization into Lassa vaccine design	42
Leveraging community engagement to shape biomedical research priorities	42
Unanticipated specificity in effector-triggered immunity	42
The five senses of immunity	42
Genotype–phenotype landscapes for immune–pathogen coevolution	42
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology	42
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The translational potential of studying bat immunity	41
High endothelial venules as potential gateways for therapeutics	40
Microglia as integrators of brain-associated molecular patterns	40
Cytosolic delivery of innate immune agonists	40
Secondary bile acids as immune and metabolic mediators	40
Advisory Board and Contents	39
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Immunology as a guide to human relationships	37
Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens	37
Astrocytes ACLYmate to chronic neuroinflammation	37
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Intracellular C1q – an unexpected player in neuronal proteostasis	37
Immune evasion in ovarian cancer: implications for immunotherapy and emerging treatments	36
Mitochondrial dysfunction in myeloid cells: a central deficit in autoimmune diseases	36
T cell control of the intestinal barrier and gut microbiota during ageing	36
Bridging anatomical gaps between brain and immune system	35
Balancing IL-17–mediated protection and IFN-γ–driven pathology at mucocutaneous barriers	35
Original antigenic sin: not so sinful after all	35
Monoallelic expression in human immune cells: linking genotype to phenotype	34
Interleukin-22: the hub bridging gut homeostasis and metabolism	34
Calreticulin surface presentation can promote quality control of hematopoietic stem cells	34
Targeting γδ T cells for immunotherapies against colorectal cancer	33
Spiking SARS-CoV-2 antiviral immunity in the respiratory tract	32
Lymphoid tissue on the mind	32

TLR9 triggers MyD88-independent anti-inflammatory signaling in lupus	32
Seven subsets, two fates: mouse γδ T cells in cancer immunity	31
Cooling inflammation through metabolism with 4-octyl itaconate	31
The complex immunological role of Helicobacter in modulating cancer	31
Advisory Board and Contents	30
Advisory Board and Contents	30
Subscription and Copyright Information	30
Immunoferroptosis: ferroptosis meets tumor immunity and immunotherapy	30
Protists protecting food tolerance	29
Exploring mucosal immune development and function in utero	29
Signaling is the pathway to macrophage function	28
The lingering shadow of epidemics: post-acute sequelae across history	28
Gut microbiota–host post-translational modification axis in immunometabolic diseases	27
Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities	27
Adenosine as a metabolic checkpoint in CD8+ T cell dysfunction	27
Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers	27
Targeting the metabolism of tumor-infiltrating regulatory T cells	27
Chimeric antigen receptor Treg therapy in transplantation	27
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Advisory Board and Contents	26
The predictive power of systems immunology	25
Protect, repair, rewire, and defend	25
New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies	25
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Advisory Board and Contents	25
Lactation, tissue-resident immunity, and protection against breast cancer	25
Redefining nucleotide-binding oligomerization domain-like receptors: from immune sentinels to multifunctional regulators	24
Parental leave in immunology—4	24
Sensory neuronal control of skin barrier immunity	24
Multiple sclerosis: role of meningeal lymphoid aggregates in progression independent of relapse activity	24
Immune-featured decidual stromal cells: pregnancy's multitasking superstars	23
A PanIN-oramic view of early pancreatic cancer in 3D	23
Sensory nerves unlock the TOLL-7 gate for cancer spread	23
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy	22
Feeding the wrath with myelin	22
Parental leave in immunology - 9	22
Regulation and impact of tumor-specific CD4+ T cells in cancer and immunotherapy	22
Overcoming gender bias in STEM	22
Partners and guardians of the nervous and immune systems	21
The diversity of cGLR receptors: shedding new light on innate immunity	21
SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences	21
How do autoimmune CD4+ T cells handle exhaustion?	21
Dancing immunity	21
Development of a circadian immune system	21
Repurposing of old drugs for unleashing innate immunity	20
COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle	20
Substance abuse and inflammation: consequences beyond the brain	19
Life and death of tolerogenic dendritic cells	19
Microbes, molecules, and the maternal–fetal interface: rethinking the gut–placenta axis	19
Lymph node fibroblast-produced extracellular matrix shapes immune function	18
Molecular mechanisms of type 2 innate immune sensing	18
B cell phylogenetics in the single cell era	18
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases	18
Inflammasome diversity: exploring novel frontiers in the innate immune response	18
Advisory Board and Contents	17
cGAS-like receptors: back to the future	17
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Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment	17
Local cues, local killers: human natural killer cells across tissues	16
News from the T cell trogocytosis front	16
Post-translational modifications of NLRP3: to prime or not to prime?	16
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis	16
Human neutrophil kinetics: a call to revisit old evidence	16
Breaking down IgA: Tomasiella immunophila enlightens microbiome–immune interactions	15
Advances in human myeloid-engrafting NSG-SGM3 and MISTRG mice	15
Afucosylated IgG responses in humans – structural clues to the regulation of humoral immunity	15
RNA circuits and RNA-binding proteins in T cells	15
Advisory Board and Contents	15
Molecular mimicry as a driver of T cell-mediated tumour immunity	14
Revisiting the macrophage disappearance reaction	13
Neuro–immune crosstalk: focus on innate lymphoid cells	13
Exhausted CD8+ T cells face a developmental fork in the road	13
IEL–IEC circuit in barrier immunity and beyond	13
Physiological role of cytokines in the regulation of mammalian metabolism	13
SIRT6 bridges glycolysis and epigenetics to neutrophilic asthma	13
Advisory Board and Contents	13
Macrophage states: there's a method in the madness	13
Restriction factors regulating human herpesvirus infections	13
Inflammasomopathies: mechanisms and disease signatures	13
T cell TET2 disruption cuts the breaks on antitumor CAR T cell therapy	13

New insights into transcription elongation control of HIV-1 latency and rebound	12
The T cell subsetting challenge	12
Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?	12
Advisory Board and Contents	12
Channel plan: control of adaptive immune responses by pannexins	12
A microbiota-derived antigen drives CD4+ intraepithelial lymphocyte (CD4IEL) development	12
Prenatal inflammation shapes microglial immune response into adulthood	12
Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine	12
Uniting innate and adaptive immunity in glioblastoma; an α-CTLA-4 quest	11
Humans pIKK-up NLRP3 to skip NEK7	11
Monoclonal antibodies lock down SARS-CoV-2 spike	11
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Advisory Board and Contents	11
Advisory Board and Contents	11
Advisory Board and Contents	11
Introducing the 'Significance' box in Trends in Immunology articles	10
Using TCR-CAR dual signaling for precise cancer targeting	10
Ghrelin and leptin regulating wound healing	10
Enhancing tumor immunity via in vivo cDC1 reprogramming	10
Microglia replacement: from monocytic origin to therapy	9
Malaria: influence of Anopheles mosquito saliva on Plasmodium infection	9
Parental leave in immunology – 1	9
Affinity-independent plasma cell differentiation in germinal centers	9
Approaches for studying neuroimmune interactions in Alzheimer’s disease	9
Targeting TLR2 agonists as immunomodulators with broad antiviral activity	9
Cryptic but critical: non-canonical antigens in cancer immunotherapy	9
Towards a quantitative theory of tolerance	9
Cell intrinsic versus cell extrinsic control of plasma cell longevity	9
Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond	9
Locus architecture and RAG scanning determine antibody diversity	9
Parental leave in immunology—2	9
Aching to defend: spleen innervation drives humoral immunity	9
Regional specialization within the mammalian respiratory immune system	9
Enlightening Per2-suasive role of neutrophils in antibacterial immunity	8
Deciphering SARS-CoV-2 evolution under antibody immune pressure	8
Maternal diet shapes the development and identity of tissue-resident macrophages	8
Targeting immune evasion in hepatocellular carcinoma-initiating cells	8
Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death	8
Structure-based mechanisms of 2′3′-cGAMP intercellular transport in the cGAS–STING immune pathway	8
Gutsy sensations modulate intestinal disease	8
Mutagenic repair during antibody diversification: emerging insights	8
Genetic conflicts and the origin of self/nonself-discrimination in the vertebrate immune system	8
Germinal centre B cell disruption by non-typhoidal Salmonella	8
Scaling immunity: sickness as a host defense strategy	8
Advisory Board and Contents	8
Advisory Board and Contents	8
Subscription and Copyright Information	8
Multiscale geometric and topological analyses for characterizing and predicting immune responses from single cell data	8
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Microglia pack a toolbox for life	8
ADAR1 and ZBP1 in innate immunity, cell death, and disease	8
Recombinant snake antivenoms get closer to the clinic	7
The Vibrio cholerae maneuver	7
Transcriptional control of natural killer cell antitumor activity	7
Get with the program: regulation of T cell death	7
Neuronal inflammasomes: balancing immunity, neuroinflammation, and homeostasis	7
Embryonic microglia maintain the brain's cortical fault lines	7
Over but not gone: lingering epigenetic effects of COVID-19	7
The putative contribution of cellular senescence to driving tauopathies	7
Got milk? how T cells shape lactation and beyond	7
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Lung tumor immunity: redirecting macrophages through infection-induced inflammation	7
The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder	7
Helper ILCs in the human hematopoietic system	7
Targeting the fate of exhausted CD8+ T cells	6
Advisory Board and Contents	6
Complement(ing) long-COVID thromboinflammation and pathogenesis	6
Leveraging deep learning to improve vaccine design	6
Boosting peripheral immunity to fight neurodegeneration in the brain	6
Diet and immune response: how today’s plate shapes tomorrow’s health	6
Tracking tumor-specific CD8+ T cell responses	6
Decoding microglial functions in Alzheimer’s disease: insights from human models	6
Why do central nervous system barriers host a diverse immune landscape?	6
The heightened importance of the microbiome in cancer immunotherapy	6
Epigenetically programmed identity crisis to combat diffuse large B cell lymphoma	6
Towards decoding the space-time continuum of pregnancy	6
Approaches for studying human macrophages	6
Modeling human immune responses to vaccination in vitro	6
Parental leave in immunology — 5	6
Group 3 innate lymphoid cells: guardians of intestinal homeostasis	5
Endothelial cells modulate immune cell responses during atherosclerosis	5
One degree of separation: urgent questions surrounding new USA laws in women’s healthcare	5
Restraining the killers: regulation of T cell quiescence	5
Parental leave in immunology — 8	5
Beyond antiviral: role of IFN-I in brain development	5
Advisory Board and Contents	5
Macrophage immunotherapy: overcoming impediments to realize promise	5
ZBTB46 in ILC3: shared transcriptional infrastructure defines gut-protective capabilities	5
Nanotube-mediated mitochondrial transfer: power to the T cells!	5
Pathways and mechanisms of CD4+CD8αα+ intraepithelial T cell development	5
Base editors dissect genetic variants in human hematopoietic cells on a large scale	5
Mitochondrial Ca2+ signaling: A metabolic rheostat defining tumor and immune cell fate	5
NF-κB: blending metabolism, immunity, and inflammation	5
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Leveraging human immune organoids for rational vaccine design	5