Trends in Molecular Medicine

Article	Citations
Advisory Board and Contents	233
Subscription and Copyright Information	219
Advisory Board and Contents	203
Subscription and Copyright Information	170
Consideration of the importance of measuring thermal discomfort in biomedical research	166
Advisory Board and Contents	166
Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes	147
Fc-optimized checkpoint antibodies for cancer immunotherapy	133
Bursts of brain erosion: seizures and age-dependent neurological vulnerability	121
Opportunities and challenges for biomarker discovery using electronic health record data	116
Subscription and Copyright Information	108
Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates	106
Subscription and Copyright Information	101
Subscription and Copyright Information	99
Beneath the radar: immune-evasive cell sources for stroke therapy	97
Advisory Board and Contents	93
Stories in Molecular Medicine December 2021	89
Neutrophils and extracellular traps in crystal-associated diseases	83
Pushing the boundaries of brain organoids to study Alzheimer’s disease	80
m6A and beyond: RNA modifications shaping angiogenesis	79
Microbiota: a dawn for cancer metastasis therapy	74
d-Amino acids: new clinical pathways for brain diseases	72
Cellular senescence in neuroinflammatory disease: new therapies for old cells?	72
Advancements in intensive eating disorder treatments: the benefit of CBT-E and integrated care models	70
Microbes and mood: innovative biomarker approaches in depression	70

Insights from HIV-1 vaccine and passive immunization efficacy trials	67
Advisory Board and Contents	66
Emerging roles of cyclin-dependent kinase 7 in health and diseases	64
Amyloid and collagen templates in aortic valve calcification	64
Brain-specific regulatory T cell expansion limits cognitive decline	63
Subscription and Copyright Information	62
Systemically administered alcadein peptide p3-Alcβ neutralizes brain Alzheimer’s Aβ oligomers	56
Epigenetic regulation in intervertebral disc degeneration	55
Stories in Molecular Medicine November 2021	53
Engineering cytokines for tumor-targeting and selective T cell activation	52
Erythropoietic protoporphyrias: updates and advances	52
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients	52
Three ‘E’ challenges for siRNA drug development	51
Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality	48
iPSCs and DRGs: stepping stones to new pain therapies	48
RNA immunotherapy: revolutionizing cancer and autoimmune disease treatments	47
Keratinocytes: new perspectives in inflammatory skin diseases	46
Acquired resistance to immunotherapy in solid tumors	46
Promoting proteostasis by cAMP/PKA and cGMP/PKG	45
Hormesis as an adaptive response to infection	45
Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging	45
Molecular mechanisms in the pathogenesis of dengue infections	45
Significant challenges to translating breakthrough science in Mexico	44
Pathogenic mechanisms in genetically defined Ehlers–Danlos syndromes	43
Mitigating age-related somatic mutation burden	43
The endoplasmic reticulum proteostasis network and bone disease	42
SOX17: escape route from immune destruction in early CRC	41
Subscription and Copyright Information	41
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart	41
Subscription and Copyright Information	40
Advisory Board and Contents	40
Shining a light on comorbidities	40
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation	40
Leptin and male fertility: unraveling the molecular pathways, receptor functions, and therapeutic potential	39
Roadmap for developing biologically inspired therapeutics for genetic brain disorders	39
Advisory Board and Contents	39
Antibody signatures in inflammatory bowel disease: current developments and future applications	38
CircRNA perspective: new strategies for RNA therapy	38
The bleeding edge: broadening horizons for hematopoietic stem cell therapies	37
Naked mole-rats: at the heart of it	36
Timing matters: maternal milk IgG sets weaning threshold	36
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	36
Two-pronged immune evasion of pseudouridine-modified RNA	35
Saving eyesight, one gene at a time	34
Targeting mitochondrial transfer as a promising therapeutic strategy	34
Molecular disease mechanisms of human antineuronal monoclonal autoantibodies	34
Subscription and Copyright Information	33
Time-restricted feeding and Alzheimer’s disease: you are when you eat	32
Science around the world	32
Translation of gene therapy strategies for amyotrophic lateral sclerosis	31

The emerging Janus face of SVEP1 in development and disease	31
Focused ultrasound gene delivery for the treatment of neurological disorders	31
Intestinal mucus barrier: a missing piece of the puzzle in food allergy	30
Maternal obesity: new placental paradigms unfolded	29
IL-15 in CAR engineering: striking an efficacy–safety balance	29
Cystic fibrosis at a glance: from disease mechanism to therapy	28
Science around the world	28
Incorporating placental pathology into clinical care and research	28
Skin senescence: mechanisms and impact on whole-body aging	28
Advisory Board and Contents	28
ABC transporters: human disease and pharmacotherapeutic potential	27
Gasdermins in pyroptosis, inflammation, and cancer	27
Leveraging zebrafish to investigate pancreatic development, regeneration, and diabetes	27
Unraveling host genetics and microbiome genome crosstalk: a novel therapeutic approach	27
Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery	27
Fibroblasts in AKI: small army, big help	26
Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer	26
Advisory Board and Contents	26
Translational opportunities emerge from genetic influences on health	25
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health	25
Biodiversity: the overlooked source of human health	25
Leveraging cellular mechano-responsiveness for cancer therapy	25
Autoantibodies as drivers of neuropathic pain	25
Advisory Board and Contents	25
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	24
The global human gut microbiome: genes, lifestyles, and diet	24
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Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes	24
Clock-modulated checkpoints in time-restricted eating	24
iPSC-derived models for anorexia nervosa research	23
Advisory Board and Contents	23
Novel universal vaccines to mitigate emerging avian influenza viruses	23
Molecular basis and clinical implications of HIFs in cardiovascular diseases	23
Human dopaminergic system in the exercise-cognition link	22
BH3 mimetic therapies for CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia	22
Stratum corneum as polymer sheet: concept and cornification processes	21
Circadian molecular clock disruption in chronic pulmonary diseases	20
Dissecting mechanisms of fecal microbiota transplantation efficacy in disease	20
Advisory Board and Contents	20
Vaccine-based immunotherapy and related preclinical models for glioma	20
Subscription and Copyright Information	20
Subscription and Copyright Information	20
HPV integration and cervical cancer: a failed evolutionary viral trait	19
Subscription and Copyright Information	19
Understanding the tuberculosis granuloma: the matrix revolutions	19
TIM-3 blockade: immune and targeted therapy in DIPG	19
mRNA vaccine platforms to prevent bacterial infections	19
Autoimmune diseases and cardiovascular risk	19
Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias	19
Advisory Board and Contents	19
Deciphering the MYCN-driven metabolic microenvironment of neuroblastoma	19
Glycosylation of blood cells during the onset and progression of atherosclerosis and myocardial infarction	19
Asthma exacerbations: the Achilles heel of asthma care	19
Advisory Board and Contents	18
Renin–angiotensin system: a novel target for brain health	18
AAV capsid design: A Goldilocks challenge	18
Vitiligo: advances in pathophysiology research and treatment development	18
Staging of Alzheimer’s disease: past, present, and future perspectives	18
Organ-specific aging in the plasma proteome predicts disease	17
Thirty years of molecular medicine: reflections from an academic physician-scientist, 1995–2025	17
The dual role of the TSC complex in cancer	17
The future of phage therapy in the USA	17
Tertiary lymphoid structures in the central nervous system	17
Treating Niemann-Pick C lysosomal storage: approved and emerging approaches	17
There is nothing as inconsistent as the OSFED diagnostic criteria	16
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases	16
Common mechanisms in pediatric acute liver failure	16
Copy number alterations: a catastrophic orchestration of the breast cancer genome	16
Telomere biology disorders: time for moving towards the clinic?	16
Missing links in preeclampsia cell model systems of endothelial dysfunction	16
Dysfunctional tRNA reprogramming and codon-biased translation in cancer	16
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections	16
Thymic stroma and TFII-I: towards new targeted therapies	16
Why we must fight ignorance about COVID-19 vaccines and menstrual cycles	16
Redefining metalloproteases specificity through network proteolysis	16
Treatment and research needs for severe eating disorders: a response to Dr Ayton	15
IL-6: a pivotal molecule for tumor–brain dysfunction interaction	15
Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology	15
Clinical crusade: zosurabalpin's charge against antibiotic resistance	15
Primary cilia shape hallmarks of health and aging	15

Advisory Board and Contents	15
Multiomics tools for improved atherosclerotic cardiovascular disease management	15
Rejuvenating the human gut microbiome	15
Nanocarrier vaccines for respiratory infections	15
The aging lipidome: exercise is medicine	15
Safety of non-replicative and oncolytic replication-selective HSV vectors	14
Adenoviruses in medicine: innocuous pathogen, predator, or partner	14
Dynamic rewiring of neurovasculature in health and disease	14
Cancer driver mutations: predictions and reality	14
Short-chain fatty acids in fetal development and metabolism	13
Subscription and Copyright Information	13
Bearing allostatic load: insights into a more equitable future within cardio-oncology	13
Enhancers in disease: molecular basis and emerging treatment strategies	13
Are GLP-1R agonists the long-sought-after panacea for obesity?	13
Advisory Board and Contents	13
Digital health applications for eating disorders treatment	13
Nontraditional models as research tools: the road not taken	13
Advances in Hodgkin lymphoma research	13
Secondary failure: immune responses to approved protein therapeutics	13
Brain-related sexual dimorphism in tuberous sclerosis complex: an overlooked matter	12
Novel bladder-sparing approaches in patients with muscle-invasive bladder cancer	12
The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis	12
Science around the world	12
Block, expose, and immunize: triple attack on cancer	12
Gene therapy for β-thalassemia: current and future options	12
Interdisciplinary approaches for the discovery of novel antifungals	12
Subscription and Copyright Information	12
Understanding preeclampsia: from phenotypes to treatment	12
Clonal hematopoiesis of indeterminate potential: the root cause of, and fertile ground for, hematological malignancies	12
Targeting pathological ERK1/2 signaling in cancer and beyond	12
Nanobodies as a powerful platform for biomedicine	11
Updates and advances in pyruvate kinase deficiency	11
Cholesterol efflux in HIV-associated atherosclerosis: mechanisms and targets	11
Metabolic symphony coordinates the muscle regeneration niche	11
Correction to: siRNA modification and delivery for drug development	11
Pig models for translational Duchenne muscular dystrophy research	11
Epigenetic regulation of tumor-immune symbiosis in glioma	11
Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases	11
Development of asparagine endopeptidase inhibitors for treating neurodegenerative diseases	11
From pathophysiology to treatment in transthyretin cardiac amyloidosis	11
Subscription and Copyright Information	11
Advisory Board and Contents	11
Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements	11
Cell-free and extrachromosomal DNA profiling of small cell lung cancer	11
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Patients as biomedical researchers	10
Next-generation immune profiling – beyond blood cancer cells	10
Advisory Board and Contents	10
NK cells in the brain: implications for brain tumor development and therapy	10
The body is not just impacted by eating disorders – biology drives them	10
PIK3CA-related overgrowth: silver bullets from the cancer arsenal?	10
Subscription and Copyright Information	10
Antibody class-switching as a strategy to improve HIV-1 neutralization	10
Genetic causes of obesity: mapping a path forward	10
Advisory Board and Contents	10
Nutrition interventions in congenital disorders of glycosylation	10
Subscription and Copyright Information	9
Exposing the role of metals in neurological disorders: a focus on manganese	9
Erythrophagocytes in hemolytic anemia, wound healing, and cancer	9
Can’t handle the stress? Mechanobiology and disease	9
ILC2s in cancer: good, bad, or stay tuned?	9
Recent insights into lysosomal acid lipase deficiency	9
Exploiting pancreatic cancer metabolism: challenges and opportunities	9
Physical activity, cathepsin B, and cognitive health	9
Science around the world	8
Advancements and challenges in mouse models of Alzheimer’s disease	8
Powering immunity: mitochondrial dynamics in natural killer cells	8
Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies	8
Subscription and Copyright Information	8
Pulmonary fibrosis: from pathogenesis to clinical decision-making	8
Technologies for chimeric antigen receptor transgene delivery	8
Translating osteoarthritis genetics research: challenging times ahead	8
Burden of hereditary enamel disorders	8
Psoriatic arthritis: diagnosis, pathogenesis, and emerging therapies	8
A sex-biased target against demyelination in Alzheimer’s disease	8
Unlocking the potential of agonist antibodies for treating cancer using antibody engineering	7
Convalescent plasma to deliver therapeutic antibodies against COVID-19	7
Advisory Board and Contents	7
Advisory Board and Contents	7
Imaging genomics: data fusion in uncovering disease heritability	7
Circular RNA translation: novel protein isoforms and clinical significance	7
Monoamines' role in islet cell function and type 2 diabetes risk	7
Subscription and Copyright Information	7
Suicide prevention in cancer: earlier is better	7
Advisory Board and Contents	7
Microbiome-targeted interventions for the control of oral–gut dysbiosis and chronic systemic inflammation	7
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New insights into gut microbiota–prostate cancer crosstalk	7
Molecular links between allergy and cancer	7
RyR-mediated calcium release in hippocampal health and disease	7
SARS-CoV-2 targets the liver and manipulates glucose metabolism	7
Subscription and Copyright Information	7
Post-acute anti-NMDAR encephalitis mirrors schizophrenia	7
Polycystic kidney disease: novel insights into polycystin function	7
Cancer quiescence: non-coding RNAs in the spotlight	7