Trends in Molecular Medicine

Article	Citations
Advisory Board and Contents	269
Subscription and Copyright Information	211
Subscription and Copyright Information	194
Advisory Board and Contents	179
Stories in Molecular Medicine December 2021	176
Advisory Board and Contents	170
Subscription and Copyright Information	148
Advisory Board and Contents	126
Subscription and Copyright Information	110
Subscription and Copyright Information	110
Pre-eclampsia: Challenges for Nanomedicine Development in Pregnancy	107
Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates	105
Bursts of brain erosion: seizures and age-dependent neurological vulnerability	102
Consideration of the importance of measuring thermal discomfort in biomedical research	98
Fc-optimized checkpoint antibodies for cancer immunotherapy	92
Neutrophils and extracellular traps in crystal-associated diseases	91
Opportunities and challenges for biomarker discovery using electronic health record data	87
Cellular senescence in neuroinflammatory disease: new therapies for old cells?	84
Pushing the boundaries of brain organoids to study Alzheimer’s disease	84
Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes	79
Beneath the radar: immune-evasive cell sources for stroke therapy	78
d-Amino acids: new clinical pathways for brain diseases	76
Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors	72
Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines	70
m6A and beyond: RNA modifications shaping angiogenesis	69

Advancements in intensive eating disorder treatments: the benefit of CBT-E and integrated care models	68
Stories in Molecular Medicine November 2021	65
Subscription and Copyright Information	65
Systemically administered alcadein peptide p3-Alcβ neutralizes brain Alzheimer’s Aβ oligomers	65
Engineering cytokines for tumor-targeting and selective T cell activation	60
Insights from HIV-1 vaccine and passive immunization efficacy trials	59
Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation	57
Acquired resistance to immunotherapy in solid tumors	57
Brain-specific regulatory T cell expansion limits cognitive decline	56
Cell-free circulating tumor DNA profiling in cancer management	56
Emerging roles of cyclin-dependent kinase 7 in health and diseases	53
Microbes and mood: innovative biomarker approaches in depression	52
Advisory Board and Contents	49
Erythropoietic protoporphyrias: updates and advances	48
Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality	47
Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging	47
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients	46
iPSCs and DRGs: stepping stones to new pain therapies	46
Molecular mechanisms in the pathogenesis of dengue infections	44
Keratinocytes: new perspectives in inflammatory skin diseases	43
In Utero Gene Therapy: Progress and Challenges	43
Epigenetic regulation in intervertebral disc degeneration	43
Amyloid and collagen templates in aortic valve calcification	42
Hormesis as an adaptive response to infection	42
Promoting proteostasis by cAMP/PKA and cGMP/PKG	41
Three ‘E’ challenges for siRNA drug development	41
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation	40
Mitigating age-related somatic mutation burden	40
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart	40
Significant challenges to translating breakthrough science in Mexico	39
Advisory Board and Contents	38
Leptin and male fertility: unraveling the molecular pathways, receptor functions, and therapeutic potential	38
Advisory Board and Contents	37
Shining a light on comorbidities	37
Subscription and Copyright Information	37
Roadmap for developing biologically inspired therapeutics for genetic brain disorders	36
Clinical implications of vitamin B12 as redox-active cofactor	36
Subscription and Copyright Information	36
SOX17: escape route from immune destruction in early CRC	36
Pathogenic mechanisms in genetically defined Ehlers–Danlos syndromes	36
CircRNA perspective: new strategies for RNA therapy	35
Antibody signatures in inflammatory bowel disease: current developments and future applications	35
Science around the world	34
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	34
Subscription and Copyright Information	34
The bleeding edge: broadening horizons for hematopoietic stem cell therapies	33
Targeting mitochondrial transfer as a promising therapeutic strategy	33
Time-restricted feeding and Alzheimer’s disease: you are when you eat	33
Molecular disease mechanisms of human antineuronal monoclonal autoantibodies	33
Naked mole-rats: at the heart of it	32

Translation of gene therapy strategies for amyotrophic lateral sclerosis	32
Saving eyesight, one gene at a time	31
Intestinal mucus barrier: a missing piece of the puzzle in food allergy	30
Maternal obesity: new placental paradigms unfolded	30
Focused ultrasound gene delivery for the treatment of neurological disorders	30
Skin senescence: mechanisms and impact on whole-body aging	30
The emerging Janus face of SVEP1 in development and disease	29
Advisory Board and Contents	28
Predicting Bone Regeneration with a Simple Blood Test	28
Advisory Board and Contents	27
Science around the world	27
Advisory Board and Contents	27
Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery	26
Leveraging zebrafish to investigate pancreatic development, regeneration, and diabetes	26
Cystic fibrosis at a glance: from disease mechanism to therapy	25
Translational opportunities emerge from genetic influences on health	25
Unraveling host genetics and microbiome genome crosstalk: a novel therapeutic approach	25
Gasdermins in pyroptosis, inflammation, and cancer	25
Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer	25
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health	25
Biodiversity: the overlooked source of human health	25
Clock-modulated checkpoints in time-restricted eating	24
Leveraging cellular mechano-responsiveness for cancer therapy	24
Incorporating placental pathology into clinical care and research	24
Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome	24
Subscription and Copyright Information	23
Subscription and Copyright Information	23
ABC transporters: human disease and pharmacotherapeutic potential	23
Advisory Board and Contents	23
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes	23
Advisory Board and Contents	23
The global human gut microbiome: genes, lifestyles, and diet	23
Historical Perspective of Clinical Nano and Microparticle Formulations for Delivery of Therapeutics	22
Dissecting mechanisms of fecal microbiota transplantation efficacy in disease	22
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	22
Molecular Mechanisms and Treatment Options of Nephropathic Cystinosis	22
Molecular basis and clinical implications of HIFs in cardiovascular diseases	22
Novel universal vaccines to mitigate emerging avian influenza viruses	22
Stratum corneum as polymer sheet: concept and cornification processes	22
iPSC-derived models for anorexia nervosa research	22
Circadian molecular clock disruption in chronic pulmonary diseases	21
Cancer Surgery 2.0: Guidance by Real-Time Molecular Technologies	21
Subscription and Copyright Information	20
Advisory Board and Contents	20
Subscription and Copyright Information	20
Human dopaminergic system in the exercise-cognition link	20
Autoimmune diseases and cardiovascular risk	20
TIM-3 blockade: immune and targeted therapy in DIPG	20
AAV-Mediated Gene Therapy for Glycosphingolipid Biosynthesis Deficiencies	20
Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias	20
mRNA vaccine platforms to prevent bacterial infections	19
Glycosylation of blood cells during the onset and progression of atherosclerosis and myocardial infarction	19
AAV capsid design: A Goldilocks challenge	19
Vaccine-based immunotherapy and related preclinical models for glioma	19
Asthma exacerbations: the Achilles heel of asthma care	19
HPV integration and cervical cancer: a failed evolutionary viral trait	19
Vitiligo: advances in pathophysiology research and treatment development	19
Staging of Alzheimer’s disease: past, present, and future perspectives	18
Advisory Board and Contents	18
Understanding the tuberculosis granuloma: the matrix revolutions	18
Why we must fight ignorance about COVID-19 vaccines and menstrual cycles	17
Missing links in preeclampsia cell model systems of endothelial dysfunction	17
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases	17
Treating Niemann-Pick C lysosomal storage: approved and emerging approaches	17
Tertiary lymphoid structures in the central nervous system	17
There is nothing as inconsistent as the OSFED diagnostic criteria	17
Thymic stroma and TFII-I: towards new targeted therapies	17
The dual role of the TSC complex in cancer	16
Strategies to Identify Genetic Variants Causing Infertility	16
The future of phage therapy in the USA	16
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections	16
Thirty years of molecular medicine: reflections from an academic physician-scientist, 1995–2025	16
Telomere biology disorders: time for moving towards the clinic?	16
Extracellular matrix-based cancer targeting	15
Dysfunctional tRNA reprogramming and codon-biased translation in cancer	15
Common mechanisms in pediatric acute liver failure	15
Organ-specific aging in the plasma proteome predicts disease	15
Redefining metalloproteases specificity through network proteolysis	15
Copy number alterations: a catastrophic orchestration of the breast cancer genome	15
Nanocarrier vaccines for respiratory infections	14

Treatment and research needs for severe eating disorders: a response to Dr Ayton	14
The aging lipidome: exercise is medicine	14
Multiomics tools for improved atherosclerotic cardiovascular disease management	14
Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology	14
Advisory Board and Contents	14
Primary cilia shape hallmarks of health and aging	14
Clinical crusade: zosurabalpin's charge against antibiotic resistance	14
Rejuvenating the human gut microbiome	14
Dynamic rewiring of neurovasculature in health and disease	14
Stories in Molecular Medicine June 2021	14
Advisory Board and Contents	14
Secondary failure: immune responses to approved protein therapeutics	14
Enhancers in disease: molecular basis and emerging treatment strategies	14
Advisory Board and Contents	13
Safety of non-replicative and oncolytic replication-selective HSV vectors	13
Are GLP-1R agonists the long-sought-after panacea for obesity?	13
Subscription and Copyright Information	13
Cancer driver mutations: predictions and reality	13
Short-chain fatty acids in fetal development and metabolism	13
Advisory Board and Contents	13
Adenoviruses in medicine: innocuous pathogen, predator, or partner	13
Digital health applications for eating disorders treatment	12
Bearing allostatic load: insights into a more equitable future within cardio-oncology	12
Stories in Molecular Medicine July 2021	12
Advances in Hodgkin lymphoma research	12
Circadian Angiopoietin-Like-4 as a Novel Therapy in Cardiovascular Disease	11
Nontraditional models as research tools: the road not taken	11
Subscription and Copyright Information	11
Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements	11
Gene therapy for β-thalassemia: current and future options	11
Interdisciplinary approaches for the discovery of novel antifungals	11
Subscription and Copyright Information	11
The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis	11
Brain-related sexual dimorphism in tuberous sclerosis complex: an overlooked matter	11
Science around the world	11
Advisory Board and Contents	11
Novel bladder-sparing approaches in patients with muscle-invasive bladder cancer	10
Advisory Board and Contents	10
Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases	10
Clonal hematopoiesis of indeterminate potential: the root cause of, and fertile ground for, hematological malignancies	10
Nanobodies as a powerful platform for biomedicine	10
Updates and advances in pyruvate kinase deficiency	10
Preimplantation Genetic Testing for Aneuploidy – a Castle Built on Sand	10
Epigenetic regulation of tumor-immune symbiosis in glioma	10
Pig models for translational Duchenne muscular dystrophy research	10
Physical activity, cathepsin B, and cognitive health	10
Advisory Board and Contents	9
Advancements and challenges in mouse models of Alzheimer’s disease	9
Development of asparagine endopeptidase inhibitors for treating neurodegenerative diseases	9
Subscription and Copyright Information	9
Correction to: siRNA modification and delivery for drug development	9
The body is not just impacted by eating disorders – biology drives them	9
Can’t handle the stress? Mechanobiology and disease	9
Genetic causes of obesity: mapping a path forward	9
Subscription and Copyright Information	9
Antibody class-switching as a strategy to improve HIV-1 neutralization	9
Erythrophagocytes in hemolytic anemia, wound healing, and cancer	9
NK cells in the brain: implications for brain tumor development and therapy	8
Exploiting pancreatic cancer metabolism: challenges and opportunities	8
Advisory Board and Contents	8
Science around the world	8
Suicide prevention in cancer: earlier is better	8
Subscription and Copyright Information	8
SARS-CoV-2 targets the liver and manipulates glucose metabolism	8
Cell-free and extrachromosomal DNA profiling of small cell lung cancer	8
PIK3CA-related overgrowth: silver bullets from the cancer arsenal?	8
Pulmonary fibrosis: from pathogenesis to clinical decision-making	8
Nutrition interventions in congenital disorders of glycosylation	8
A sex-biased target against demyelination in Alzheimer’s disease	8
Molecular therapy for polyQ disorders: from bench to clinical trials	8
Advisory Board and Contents	8
Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?	8
Recent insights into lysosomal acid lipase deficiency	8
Patients as biomedical researchers	8
Advisory Board and Contents	8
Subscription and Copyright Information	8
Post-acute anti-NMDAR encephalitis mirrors schizophrenia	8
Translating osteoarthritis genetics research: challenging times ahead	8
Stories in Molecular Medicine September 2021	8
Exposing the role of metals in neurological disorders: a focus on manganese	8
Powering immunity: mitochondrial dynamics in natural killer cells	7
Convalescent plasma to deliver therapeutic antibodies against COVID-19	7
Circular RNA translation: novel protein isoforms and clinical significance	7
The inaccessible road to science for people with disabilities	7
Polycystic kidney disease: novel insights into polycystin function	7
Microbiome-targeted interventions for the control of oral–gut dysbiosis and chronic systemic inflammation	7
Imaging genomics: data fusion in uncovering disease heritability	7
Advisory Board and Contents	7
Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies	7
RyR-mediated calcium release in hippocampal health and disease	7
Stories in Molecular Medicine October 2021	7
Subscription and Copyright Information	7
Cancer quiescence: non-coding RNAs in the spotlight	6
Advisory Board and Content	6
Is there a place for engineered immune cell therapies in autoimmune diseases?	6