Trends in Molecular Medicine

Article	Citations
Advisory Board and Contents	228
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Subscription and Copyright Information	198
Advisory Board and Contents	193
Stories in Molecular Medicine December 2021	186
Subscription and Copyright Information	156
Advisory Board and Contents	156
Advisory Board and Contents	149
Subscription and Copyright Information	123
Subscription and Copyright Information	121
m6A and beyond: RNA modifications shaping angiogenesis	118
Fc-optimized checkpoint antibodies for cancer immunotherapy	115
Bursts of brain erosion: seizures and age-dependent neurological vulnerability	110
Pushing the boundaries of brain organoids to study Alzheimer’s disease	109
Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates	101
Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes	100
Consideration of the importance of measuring thermal discomfort in biomedical research	100
Neutrophils and extracellular traps in crystal-associated diseases	95
Opportunities and challenges for biomarker discovery using electronic health record data	89
Beneath the radar: immune-evasive cell sources for stroke therapy	88
Cellular senescence in neuroinflammatory disease: new therapies for old cells?	87
d-Amino acids: new clinical pathways for brain diseases	79
Advancements in intensive eating disorder treatments: the benefit of CBT-E and integrated care models	76
Subscription and Copyright Information	76
Stories in Molecular Medicine November 2021	73

Systemically administered alcadein peptide p3-Alcβ neutralizes brain Alzheimer’s Aβ oligomers	68
Brain-specific regulatory T cell expansion limits cognitive decline	67
Insights from HIV-1 vaccine and passive immunization efficacy trials	67
Engineering cytokines for tumor-targeting and selective T cell activation	66
Acquired resistance to immunotherapy in solid tumors	64
Amyloid and collagen templates in aortic valve calcification	63
Erythropoietic protoporphyrias: updates and advances	63
Molecular mechanisms in the pathogenesis of dengue infections	61
Three ‘E’ challenges for siRNA drug development	60
iPSCs and DRGs: stepping stones to new pain therapies	54
Microbes and mood: innovative biomarker approaches in depression	53
Cell-free circulating tumor DNA profiling in cancer management	53
Advisory Board and Contents	52
Emerging roles of cyclin-dependent kinase 7 in health and diseases	51
Keratinocytes: new perspectives in inflammatory skin diseases	49
RNA immunotherapy: revolutionizing cancer and autoimmune disease treatments	49
Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality	48
Epigenetic regulation in intervertebral disc degeneration	46
Hormesis as an adaptive response to infection	46
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients	45
Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging	44
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart	44
Promoting proteostasis by cAMP/PKA and cGMP/PKG	44
Mitigating age-related somatic mutation burden	43
Significant challenges to translating breakthrough science in Mexico	43
Leptin and male fertility: unraveling the molecular pathways, receptor functions, and therapeutic potential	43
Advisory Board and Contents	42
Advisory Board and Contents	42
Shining a light on comorbidities	42
Subscription and Copyright Information	41
Roadmap for developing biologically inspired therapeutics for genetic brain disorders	40
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SOX17: escape route from immune destruction in early CRC	39
Pathogenic mechanisms in genetically defined Ehlers–Danlos syndromes	39
The endoplasmic reticulum proteostasis network and bone disease	38
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation	38
CircRNA perspective: new strategies for RNA therapy	38
Antibody signatures in inflammatory bowel disease: current developments and future applications	37
Science around the world	36
Translation of gene therapy strategies for amyotrophic lateral sclerosis	36
Subscription and Copyright Information	36
Naked mole-rats: at the heart of it	36
Clinical implications of vitamin B12 as redox-active cofactor	36
Saving eyesight, one gene at a time	35
The emerging Janus face of SVEP1 in development and disease	35
Molecular disease mechanisms of human antineuronal monoclonal autoantibodies	34
The bleeding edge: broadening horizons for hematopoietic stem cell therapies	34
Time-restricted feeding and Alzheimer’s disease: you are when you eat	33
Targeting mitochondrial transfer as a promising therapeutic strategy	33
Intestinal mucus barrier: a missing piece of the puzzle in food allergy	32

From pixels to patients: the evolution and future of deep learning in cancer diagnostics	32
Maternal obesity: new placental paradigms unfolded	32
IL-15 in CAR engineering: striking an efficacy–safety balance	31
Focused ultrasound gene delivery for the treatment of neurological disorders	31
Skin senescence: mechanisms and impact on whole-body aging	29
Advisory Board and Contents	29
Fibroblasts in AKI: small army, big help	28
Science around the world	28
Incorporating placental pathology into clinical care and research	28
Autoantibodies as drivers of neuropathic pain	28
Advisory Board and Contents	28
Advisory Board and Contents	27
Leveraging cellular mechano-responsiveness for cancer therapy	27
Gasdermins in pyroptosis, inflammation, and cancer	27
ABC transporters: human disease and pharmacotherapeutic potential	27
Cystic fibrosis at a glance: from disease mechanism to therapy	26
Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery	26
Leveraging zebrafish to investigate pancreatic development, regeneration, and diabetes	26
Translational opportunities emerge from genetic influences on health	25
The global human gut microbiome: genes, lifestyles, and diet	25
Clock-modulated checkpoints in time-restricted eating	25
Biodiversity: the overlooked source of human health	25
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health	24
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Unraveling host genetics and microbiome genome crosstalk: a novel therapeutic approach	24
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes	24
Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer	24
Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome	24
Subscription and Copyright Information	23
iPSC-derived models for anorexia nervosa research	23
Advisory Board and Contents	23
Advisory Board and Contents	23
Stratum corneum as polymer sheet: concept and cornification processes	23
Novel universal vaccines to mitigate emerging avian influenza viruses	23
Advisory Board and Contents	23
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	23
Molecular basis and clinical implications of HIFs in cardiovascular diseases	23
Subscription and Copyright Information	22
Human dopaminergic system in the exercise-cognition link	22
Dissecting mechanisms of fecal microbiota transplantation efficacy in disease	22
Advisory Board and Contents	22
Circadian molecular clock disruption in chronic pulmonary diseases	22
TIM-3 blockade: immune and targeted therapy in DIPG	21
Vitiligo: advances in pathophysiology research and treatment development	20
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Vaccine-based immunotherapy and related preclinical models for glioma	19
Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias	19
Autoimmune diseases and cardiovascular risk	19
Glycosylation of blood cells during the onset and progression of atherosclerosis and myocardial infarction	19
mRNA vaccine platforms to prevent bacterial infections	19
Understanding the tuberculosis granuloma: the matrix revolutions	19
Staging of Alzheimer’s disease: past, present, and future perspectives	18
Advisory Board and Contents	18
Why we must fight ignorance about COVID-19 vaccines and menstrual cycles	18
AAV capsid design: A Goldilocks challenge	18
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases	18
Asthma exacerbations: the Achilles heel of asthma care	18
HPV integration and cervical cancer: a failed evolutionary viral trait	18
Thymic stroma and TFII-I: towards new targeted therapies	18
Common mechanisms in pediatric acute liver failure	17
There is nothing as inconsistent as the OSFED diagnostic criteria	17
Thirty years of molecular medicine: reflections from an academic physician-scientist, 1995–2025	17
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections	17
The future of phage therapy in the USA	16
Organ-specific aging in the plasma proteome predicts disease	16
Redefining metalloproteases specificity through network proteolysis	16
Copy number alterations: a catastrophic orchestration of the breast cancer genome	16
Tertiary lymphoid structures in the central nervous system	16
Telomere biology disorders: time for moving towards the clinic?	16
Missing links in preeclampsia cell model systems of endothelial dysfunction	16
The dual role of the TSC complex in cancer	16
Treating Niemann-Pick C lysosomal storage: approved and emerging approaches	16
Extracellular matrix-based cancer targeting	16
Advisory Board and Contents	15
Rejuvenating the human gut microbiome	15
Clinical crusade: zosurabalpin's charge against antibiotic resistance	15
Primary cilia shape hallmarks of health and aging	15
IL-6: a pivotal molecule for tumor–brain dysfunction interaction	15
The aging lipidome: exercise is medicine	15
Treatment and research needs for severe eating disorders: a response to Dr Ayton	15

Dysfunctional tRNA reprogramming and codon-biased translation in cancer	15
Secondary failure: immune responses to approved protein therapeutics	15
Dynamic rewiring of neurovasculature in health and disease	15
Multiomics tools for improved atherosclerotic cardiovascular disease management	14
Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology	14
Safety of non-replicative and oncolytic replication-selective HSV vectors	14
Advisory Board and Contents	13
Enhancers in disease: molecular basis and emerging treatment strategies	13
Are GLP-1R agonists the long-sought-after panacea for obesity?	13
Advisory Board and Contents	13
Nanocarrier vaccines for respiratory infections	13
Subscription and Copyright Information	13
Digital health applications for eating disorders treatment	13
Cancer driver mutations: predictions and reality	13
Adenoviruses in medicine: innocuous pathogen, predator, or partner	13
Bearing allostatic load: insights into a more equitable future within cardio-oncology	13
Updates and advances in pyruvate kinase deficiency	12
Short-chain fatty acids in fetal development and metabolism	12
Subscription and Copyright Information	12
Brain-related sexual dimorphism in tuberous sclerosis complex: an overlooked matter	12
Gene therapy for β-thalassemia: current and future options	12
Advisory Board and Contents	12
Science around the world	12
Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements	12
Nontraditional models as research tools: the road not taken	12
Advances in Hodgkin lymphoma research	12
Subscription and Copyright Information	12
Nanobodies as a powerful platform for biomedicine	12
Block, expose, and immunize: triple attack on cancer	11
Novel bladder-sparing approaches in patients with muscle-invasive bladder cancer	11
The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis	11
Subscription and Copyright Information	11
Understanding preeclampsia: from phenotypes to treatment	11
Epigenetic regulation of tumor-immune symbiosis in glioma	11
Clonal hematopoiesis of indeterminate potential: the root cause of, and fertile ground for, hematological malignancies	11
Advisory Board and Contents	11
Interdisciplinary approaches for the discovery of novel antifungals	11
Pig models for translational Duchenne muscular dystrophy research	11
Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases	11
Advisory Board and Contents	11
Cell-free and extrachromosomal DNA profiling of small cell lung cancer	10
Genetic causes of obesity: mapping a path forward	10
NK cells in the brain: implications for brain tumor development and therapy	10
Patients as biomedical researchers	10
Physical activity, cathepsin B, and cognitive health	10
Advancements and challenges in mouse models of Alzheimer’s disease	10
Recent insights into lysosomal acid lipase deficiency	10
Can’t handle the stress? Mechanobiology and disease	10
Subscription and Copyright Information	10
Subscription and Copyright Information	10
Correction to: siRNA modification and delivery for drug development	10
Metabolic symphony coordinates the muscle regeneration niche	10
The body is not just impacted by eating disorders – biology drives them	9
Development of asparagine endopeptidase inhibitors for treating neurodegenerative diseases	9
Erythrophagocytes in hemolytic anemia, wound healing, and cancer	9
Exploiting pancreatic cancer metabolism: challenges and opportunities	9
PIK3CA-related overgrowth: silver bullets from the cancer arsenal?	9
Next-generation immune profiling – beyond blood cancer cells	9
Cholesterol efflux in HIV-associated atherosclerosis: mechanisms and targets	9
ILC2s in cancer: good, bad, or stay tuned?	9
From pathophysiology to treatment in transthyretin cardiac amyloidosis	9
Nutrition interventions in congenital disorders of glycosylation	9
Exposing the role of metals in neurological disorders: a focus on manganese	9
Convalescent plasma to deliver therapeutic antibodies against COVID-19	8
Science around the world	8
Post-acute anti-NMDAR encephalitis mirrors schizophrenia	8
Technologies for chimeric antigen receptor transgene delivery	8
Advisory Board and Contents	8
Subscription and Copyright Information	8
Subscription and Copyright Information	8
A sex-biased target against demyelination in Alzheimer’s disease	8
Advisory Board and Contents	8
Pulmonary fibrosis: from pathogenesis to clinical decision-making	8
Advisory Board and Contents	8
Stories in Molecular Medicine September 2021	8
SARS-CoV-2 targets the liver and manipulates glucose metabolism	8
Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies	8
Antibody class-switching as a strategy to improve HIV-1 neutralization	8
Translating osteoarthritis genetics research: challenging times ahead	7
Psoriatic arthritis: diagnosis, pathogenesis, and emerging therapies	7
Circular RNA translation: novel protein isoforms and clinical significance	7
Powering immunity: mitochondrial dynamics in natural killer cells	7
RyR-mediated calcium release in hippocampal health and disease	7
Molecular therapy for polyQ disorders: from bench to clinical trials	7
Imaging genomics: data fusion in uncovering disease heritability	7
Burden of hereditary enamel disorders	7
Polycystic kidney disease: novel insights into polycystin function	7
Suicide prevention in cancer: earlier is better	7
Microbiome-targeted interventions for the control of oral–gut dysbiosis and chronic systemic inflammation	7
The molecular underpinnings of female predominance in lupus	6
Monoamines' role in islet cell function and type 2 diabetes risk	6
Harnessing the healing power of love	6
Circadian phase instability in bipolar disorder: a neglected essence	6
New strategies for the treatment of chronic hepatitis B	6
New insights into gut microbiota–prostate cancer crosstalk	6