Trends in Molecular Medicine

Article	Citations
Advisory Board and Contents	246
Subscription and Copyright Information	239
Advisory Board and Contents	211
Subscription and Copyright Information	188
Advisory Board and Contents	180
Microbiota: a dawn for cancer metastasis therapy	168
Consideration of the importance of measuring thermal discomfort in biomedical research	148
The right drug at the right time: key to IBD success	133
Fc-optimized checkpoint antibodies for cancer immunotherapy	121
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Subscription and Copyright Information	115
Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates	112
Subscription and Copyright Information	107
Bursts of brain erosion: seizures and age-dependent neurological vulnerability	105
Neutrophils and extracellular traps in crystal-associated diseases	99
Opportunities and challenges for biomarker discovery using electronic health record data	97
Cellular senescence in neuroinflammatory disease: new therapies for old cells?	89
Lymph node microenvironment rewires ferroptosis redox defenses	88
Beneath the radar: immune-evasive cell sources for stroke therapy	81
Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes	80
m6A and beyond: RNA modifications shaping angiogenesis	78
Pushing the boundaries of brain organoids to study Alzheimer’s disease	77
Advancements in intensive eating disorder treatments: the benefit of CBT-E and integrated care models	76
d-Amino acids: new clinical pathways for brain diseases	76
Microbes and mood: innovative biomarker approaches in depression	75

Advisory Board and Contents	72
Subscription and Copyright Information	70
Brain-specific regulatory T cell expansion limits cognitive decline	70
Systemically administered alcadein peptide p3-Alcβ neutralizes brain Alzheimer’s Aβ oligomers	69
iPSCs and DRGs: stepping stones to new pain therapies	69
Insights from HIV-1 vaccine and passive immunization efficacy trials	67
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients	63
Molecular mechanisms in the pathogenesis of dengue infections	62
Amyloid and collagen templates in aortic valve calcification	61
Hormesis as an adaptive response to infection	57
Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality	56
Keratinocytes: new perspectives in inflammatory skin diseases	56
Acquired resistance to immunotherapy in solid tumors	53
RNA immunotherapy: revolutionizing cancer and autoimmune disease treatments	51
Epigenetic regulation in intervertebral disc degeneration	51
Emerging roles of cyclin-dependent kinase 7 in health and diseases	50
Erythropoietic protoporphyrias: updates and advances	50
Three ‘E’ challenges for siRNA drug development	49
Significant challenges to translating breakthrough science in Mexico	49
Engineering cytokines for tumor-targeting and selective T cell activation	49
The endoplasmic reticulum proteostasis network and bone disease	48
Antibody signatures in inflammatory bowel disease: current developments and future applications	46
Mitigating age-related somatic mutation burden	45
SOX17: escape route from immune destruction in early CRC	45
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Roadmap for developing biologically inspired therapeutics for genetic brain disorders	44
Advisory Board and Contents	44
Advisory Board and Contents	43
Shining a light on comorbidities	43
Promoting proteostasis by cAMP/PKA and cGMP/PKG	42
Subscription and Copyright Information	42
Leptin and male fertility: unraveling the molecular pathways, receptor functions, and therapeutic potential	42
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart	42
Pathogenic mechanisms in genetically defined Ehlers–Danlos syndromes	41
The bleeding edge: broadening horizons for hematopoietic stem cell therapies	39
CircRNA perspective: new strategies for RNA therapy	39
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation	39
Naked mole-rats: at the heart of it	37
Translation of gene therapy strategies for amyotrophic lateral sclerosis	36
Timing matters: maternal milk IgG sets weaning threshold	35
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	35
Two-pronged immune evasion of pseudouridine-modified RNA	35
Science around the world	34
Molecular disease mechanisms of human antineuronal monoclonal autoantibodies	34
Saving eyesight, one gene at a time	34
Time-restricted feeding and Alzheimer’s disease: you are when you eat	34
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Intestinal mucus barrier: a missing piece of the puzzle in food allergy	33
Focused ultrasound gene delivery for the treatment of neurological disorders	32

IL-15 in CAR engineering: striking an efficacy–safety balance	31
Skin senescence: mechanisms and impact on whole-body aging	31
Targeting mitochondrial transfer as a promising therapeutic strategy	31
The emerging Janus face of SVEP1 in development and disease	30
Maternal obesity: new placental paradigms unfolded	30
Autoantibodies as drivers of neuropathic pain	29
Advisory Board and Contents	29
Unraveling host genetics and microbiome genome crosstalk: a novel therapeutic approach	29
Science around the world	29
Translational opportunities emerge from genetic influences on health	28
Advisory Board and Contents	28
Advisory Board and Contents	28
Cystic fibrosis at a glance: from disease mechanism to therapy	28
Clock-modulated checkpoints in time-restricted eating	27
Fibroblasts in AKI: small army, big help	27
Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery	27
Lipedema: a chronic adipose tissue disease	27
Leveraging zebrafish to investigate pancreatic development, regeneration, and diabetes	27
The overlooked uterine factor: unlocking endometrium potential in premature ovarian insufficiency	26
Gasdermins in pyroptosis, inflammation, and cancer	25
ABC transporters: human disease and pharmacotherapeutic potential	25
Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer	25
Incorporating placental pathology into clinical care and research	25
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Leveraging cellular mechano-responsiveness for cancer therapy	24
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes	24
Biodiversity: the overlooked source of human health	24
The global human gut microbiome: genes, lifestyles, and diet	24
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health	24
Novel universal vaccines to mitigate emerging avian influenza viruses	23
BH3 mimetic therapies for CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia	23
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	23
iPSC-derived models for anorexia nervosa research	23
Advisory Board and Contents	23
Advisory Board and Contents	22
Stratum corneum as polymer sheet: concept and cornification processes	22
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Human dopaminergic system in the exercise-cognition link	21
Dissecting mechanisms of fecal microbiota transplantation efficacy in disease	21
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Circadian molecular clock disruption in chronic pulmonary diseases	21
Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias	21
Molecular basis and clinical implications of HIFs in cardiovascular diseases	21
Vaccine-based immunotherapy and related preclinical models for glioma	21
Renin–angiotensin system: a novel target for brain health	20
AAV capsid design: A Goldilocks challenge	20
TIM-3 blockade: immune and targeted therapy in DIPG	20
Deciphering the MYCN-driven metabolic microenvironment of neuroblastoma	20
Glycosylation of blood cells during the onset and progression of atherosclerosis and myocardial infarction	20
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Autoimmune diseases and cardiovascular risk	20
Advisory Board and Contents	20
Understanding the tuberculosis granuloma: the matrix revolutions	19
mRNA vaccine platforms to prevent bacterial infections	19
Staging of Alzheimer’s disease: past, present, and future perspectives	19
Asthma exacerbations: the Achilles heel of asthma care	19
Organ-specific aging in the plasma proteome predicts disease	19
Vitiligo: advances in pathophysiology research and treatment development	19
Advisory Board and Contents	19
HPV integration and cervical cancer: a failed evolutionary viral trait	19
Thirty years of molecular medicine: reflections from an academic physician-scientist, 1995–2025	18
Treating Niemann-Pick C lysosomal storage: approved and emerging approaches	18
Common mechanisms in pediatric acute liver failure	17
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases	17
Dysfunctional tRNA reprogramming and codon-biased translation in cancer	17
Thymic stroma and TFII-I: towards new targeted therapies	17
Predicting healthspan and disease risks through biological age	17
There is nothing as inconsistent as the OSFED diagnostic criteria	17
Telomere biology disorders: time for moving towards the clinic?	17
Why we must fight ignorance about COVID-19 vaccines and menstrual cycles	17
Repurposing of microbial proteins as new-generation therapeutic agents for biomedical applications	17
Treatment and research needs for severe eating disorders: a response to Dr Ayton	16
Clinical crusade: zosurabalpin's charge against antibiotic resistance	16
Tertiary lymphoid structures in the central nervous system	16
Redefining metalloproteases specificity through network proteolysis	16
The future of phage therapy in the USA	16
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections	16
Missing links in preeclampsia cell model systems of endothelial dysfunction	16
Primary cilia shape hallmarks of health and aging	16
Copy number alterations: a catastrophic orchestration of the breast cancer genome	16

The dual role of the TSC complex in cancer	16
Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology	15
The aging lipidome: exercise is medicine	15
Dynamic rewiring of neurovasculature in health and disease	15
IL-6: a pivotal molecule for tumor–brain dysfunction interaction	15
Advisory Board and Contents	15
Rejuvenating the human gut microbiome	15
Safety of non-replicative and oncolytic replication-selective HSV vectors	14
Adenoviruses in medicine: innocuous pathogen, predator, or partner	14
Are GLP-1R agonists the long-sought-after panacea for obesity?	14
Multiomics tools for improved atherosclerotic cardiovascular disease management	14
Subscription and Copyright Information	14
Advances in Hodgkin lymphoma research	14
Nanocarrier vaccines for respiratory infections	14
Cancer driver mutations: predictions and reality	14
Advisory Board and Contents	14
Digital health applications for eating disorders treatment	14
Nontraditional models as research tools: the road not taken	13
Targeting pathological ERK1/2 signaling in cancer and beyond	13
Bearing allostatic load: insights into a more equitable future within cardio-oncology	13
Block, expose, and immunize: triple attack on cancer	13
Interdisciplinary approaches for the discovery of novel antifungals	13
Short-chain fatty acids in fetal development and metabolism	13
Brain-related sexual dimorphism in tuberous sclerosis complex: an overlooked matter	13
Epigenetic regulation of tumor-immune symbiosis in glioma	12
Understanding preeclampsia: from phenotypes to treatment	12
Clonal hematopoiesis of indeterminate potential: the root cause of, and fertile ground for, hematological malignancies	12
Gene therapy for β-thalassemia: current and future options	12
Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements	12
Nanobodies as a powerful platform for biomedicine	12
Science around the world	12
Advisory Board and Contents	12
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Updates and advances in pyruvate kinase deficiency	12
Toward low-cost gene therapy: mRNA-based therapeutics for treatment of inherited retinal diseases	12
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Pig models for translational Duchenne muscular dystrophy research	12
Novel bladder-sparing approaches in patients with muscle-invasive bladder cancer	12
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From pathophysiology to treatment in transthyretin cardiac amyloidosis	11
Antibody class-switching as a strategy to improve HIV-1 neutralization	11
Advisory Board and Contents	11
Correction to: siRNA modification and delivery for drug development	11
Subscription and Copyright Information	11
NK cells in the brain: implications for brain tumor development and therapy	11
Cholesterol efflux in HIV-associated atherosclerosis: mechanisms and targets	11
Advisory Board and Contents	11
Next-generation immune profiling – beyond blood cancer cells	11
Metabolic symphony coordinates the muscle regeneration niche	10
Erythrophagocytes in hemolytic anemia, wound healing, and cancer	10
Patients as biomedical researchers	10
PIK3CA-related overgrowth: silver bullets from the cancer arsenal?	10
Development of asparagine endopeptidase inhibitors for treating neurodegenerative diseases	10
Genetic causes of obesity: mapping a path forward	10
Physical activity, cathepsin B, and cognitive health	10
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ILC2s in cancer: good, bad, or stay tuned?	10
Exploiting pancreatic cancer metabolism: challenges and opportunities	10
Nutrition interventions in congenital disorders of glycosylation	10
Science around the world	9
Cell-free and extrachromosomal DNA profiling of small cell lung cancer	9
Recent insights into lysosomal acid lipase deficiency	9
Exposing the role of metals in neurological disorders: a focus on manganese	9
Advancements and challenges in mouse models of Alzheimer’s disease	9
Pulmonary fibrosis: from pathogenesis to clinical decision-making	9
The body is not just impacted by eating disorders – biology drives them	9
Can’t handle the stress? Mechanobiology and disease	9
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Suicide prevention in cancer: earlier is better	8
Post-acute anti-NMDAR encephalitis mirrors schizophrenia	8
Advisory Board and Contents	8
Burden of hereditary enamel disorders	8
Psoriatic arthritis: diagnosis, pathogenesis, and emerging therapies	8
Molecular therapy for polyQ disorders: from bench to clinical trials	8
Advisory Board and Contents	8
Technologies for chimeric antigen receptor transgene delivery	8
Advisory Board and Contents	8
A sex-biased target against demyelination in Alzheimer’s disease	8
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SARS-CoV-2 targets the liver and manipulates glucose metabolism	8
Powering immunity: mitochondrial dynamics in natural killer cells	8
Polycystic kidney disease: novel insights into polycystin function	7
Rett syndrome: a complex disorder with promising therapeutic prospects	7
Science around the world	7
Circadian phase instability in bipolar disorder: a neglected essence	7
Translating osteoarthritis genetics research: challenging times ahead	7
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Endometriosis and comorbidities: molecular mechanisms and clinical implications	7
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Circular RNA translation: novel protein isoforms and clinical significance	7
Molecular links between allergy and cancer	7
New strategies for the treatment of chronic hepatitis B	7
β2ARs: double edge sword in heart function	7
RyR-mediated calcium release in hippocampal health and disease	7