OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Molecular Medicine is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Advisory Board and Contents	240
Subscription and Copyright Information	232
Advisory Board and Contents	208
Subscription and Copyright Information	175
Advisory Board and Contents	174
Consideration of the importance of measuring thermal discomfort in biomedical research	157
Bursts of brain erosion: seizures and age-dependent neurological vulnerability	140
Fc-optimized checkpoint antibodies for cancer immunotherapy	126
Subscription and Copyright Information	117
Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates	112
Subscription and Copyright Information	111
Subscription and Copyright Information	106
Stories in Molecular Medicine December 2021	105
Neutrophils and extracellular traps in crystal-associated diseases	102
Microbiota: a dawn for cancer metastasis therapy	94
m6A and beyond: RNA modifications shaping angiogenesis	93
Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes	88
The right drug at the right time: key to IBD success	83
d-Amino acids: new clinical pathways for brain diseases	81
Cellular senescence in neuroinflammatory disease: new therapies for old cells?	75
Pushing the boundaries of brain organoids to study Alzheimer’s disease	74
Opportunities and challenges for biomarker discovery using electronic health record data	74
Beneath the radar: immune-evasive cell sources for stroke therapy	74
Advancements in intensive eating disorder treatments: the benefit of CBT-E and integrated care models	73
Microbes and mood: innovative biomarker approaches in depression	70

Engineering cytokines for tumor-targeting and selective T cell activation	68
Advisory Board and Contents	68
Subscription and Copyright Information	66
Brain-specific regulatory T cell expansion limits cognitive decline	66
Systemically administered alcadein peptide p3-Alcβ neutralizes brain Alzheimer’s Aβ oligomers	64
Erythropoietic protoporphyrias: updates and advances	60
Amyloid and collagen templates in aortic valve calcification	57
iPSCs and DRGs: stepping stones to new pain therapies	56
Acquired resistance to immunotherapy in solid tumors	56
Molecular mechanisms in the pathogenesis of dengue infections	55
Insights from HIV-1 vaccine and passive immunization efficacy trials	54
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients	52
Three ‘E’ challenges for siRNA drug development	52
RNA immunotherapy: revolutionizing cancer and autoimmune disease treatments	49
Emerging roles of cyclin-dependent kinase 7 in health and diseases	49
Hormesis as an adaptive response to infection	48
Keratinocytes: new perspectives in inflammatory skin diseases	47
Epigenetic regulation in intervertebral disc degeneration	47
Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality	47
Mitigating age-related somatic mutation burden	46
Significant challenges to translating breakthrough science in Mexico	46
The endoplasmic reticulum proteostasis network and bone disease	45
SOX17: escape route from immune destruction in early CRC	44
Subscription and Copyright Information	44
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart	43
Subscription and Copyright Information	43
Shining a light on comorbidities	43
Subscription and Copyright Information	42
Roadmap for developing biologically inspired therapeutics for genetic brain disorders	42
Advisory Board and Contents	42
Leptin and male fertility: unraveling the molecular pathways, receptor functions, and therapeutic potential	42
Advisory Board and Contents	42
Pathogenic mechanisms in genetically defined Ehlers–Danlos syndromes	41
Promoting proteostasis by cAMP/PKA and cGMP/PKG	41
CircRNA perspective: new strategies for RNA therapy	41
Antibody signatures in inflammatory bowel disease: current developments and future applications	39
The bleeding edge: broadening horizons for hematopoietic stem cell therapies	39
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation	39
Naked mole-rats: at the heart of it	37
Two-pronged immune evasion of pseudouridine-modified RNA	36
Timing matters: maternal milk IgG sets weaning threshold	36
Saving eyesight, one gene at a time	35
Subscription and Copyright Information	35
Molecular disease mechanisms of human antineuronal monoclonal autoantibodies	35
Science around the world	34
Maternal obesity: new placental paradigms unfolded	33
Intestinal mucus barrier: a missing piece of the puzzle in food allergy	33
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	33
Targeting mitochondrial transfer as a promising therapeutic strategy	32
Time-restricted feeding and Alzheimer’s disease: you are when you eat	32

IL-15 in CAR engineering: striking an efficacy–safety balance	31
Translation of gene therapy strategies for amyotrophic lateral sclerosis	30
Advisory Board and Contents	29
Skin senescence: mechanisms and impact on whole-body aging	29
Clock-modulated checkpoints in time-restricted eating	29
Science around the world	29
The emerging Janus face of SVEP1 in development and disease	29
Autoantibodies as drivers of neuropathic pain	29
Focused ultrasound gene delivery for the treatment of neurological disorders	29
Unraveling host genetics and microbiome genome crosstalk: a novel therapeutic approach	28
Translational opportunities emerge from genetic influences on health	28
Advisory Board and Contents	28
Advisory Board and Contents	28
Fibroblasts in AKI: small army, big help	27
Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery	27
Leveraging zebrafish to investigate pancreatic development, regeneration, and diabetes	27
Cystic fibrosis at a glance: from disease mechanism to therapy	27
Incorporating placental pathology into clinical care and research	27
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health	26
Gasdermins in pyroptosis, inflammation, and cancer	26
Biodiversity: the overlooked source of human health	25
The global human gut microbiome: genes, lifestyles, and diet	25
ABC transporters: human disease and pharmacotherapeutic potential	24
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes	24
Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer	24
Subscription and Copyright Information	24
Leveraging cellular mechano-responsiveness for cancer therapy	24
From pixels to patients: the evolution and future of deep learning in cancer diagnostics	24
iPSC-derived models for anorexia nervosa research	23
Novel universal vaccines to mitigate emerging avian influenza viruses	23
BH3 mimetic therapies for CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia	23
Advisory Board and Contents	23
Subscription and Copyright Information	22
Advisory Board and Contents	22
Stratum corneum as polymer sheet: concept and cornification processes	22
Circadian molecular clock disruption in chronic pulmonary diseases	21
Dissecting mechanisms of fecal microbiota transplantation efficacy in disease	21
Molecular basis and clinical implications of HIFs in cardiovascular diseases	20
TIM-3 blockade: immune and targeted therapy in DIPG	20
Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias	20
Glycosylation of blood cells during the onset and progression of atherosclerosis and myocardial infarction	20
Subscription and Copyright Information	20
Subscription and Copyright Information	20
Advisory Board and Contents	20
Vaccine-based immunotherapy and related preclinical models for glioma	20
Human dopaminergic system in the exercise-cognition link	20
Staging of Alzheimer’s disease: past, present, and future perspectives	19
Understanding the tuberculosis granuloma: the matrix revolutions	19
Renin–angiotensin system: a novel target for brain health	19
Deciphering the MYCN-driven metabolic microenvironment of neuroblastoma	19
Asthma exacerbations: the Achilles heel of asthma care	19
Advisory Board and Contents	19
Vitiligo: advances in pathophysiology research and treatment development	19
AAV capsid design: A Goldilocks challenge	19
HPV integration and cervical cancer: a failed evolutionary viral trait	19
mRNA vaccine platforms to prevent bacterial infections	19
Autoimmune diseases and cardiovascular risk	19
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases	18
Organ-specific aging in the plasma proteome predicts disease	18
Thymic stroma and TFII-I: towards new targeted therapies	18
Missing links in preeclampsia cell model systems of endothelial dysfunction	18
Primary cilia shape hallmarks of health and aging	17
Tertiary lymphoid structures in the central nervous system	17
Why we must fight ignorance about COVID-19 vaccines and menstrual cycles	17
Telomere biology disorders: time for moving towards the clinic?	17
Common mechanisms in pediatric acute liver failure	17
Thirty years of molecular medicine: reflections from an academic physician-scientist, 1995–2025	17
The dual role of the TSC complex in cancer	17
Treating Niemann-Pick C lysosomal storage: approved and emerging approaches	17
Redefining metalloproteases specificity through network proteolysis	16
Predicting healthspan and disease risks through biological age	16
Clinical crusade: zosurabalpin's charge against antibiotic resistance	16
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections	16
Treatment and research needs for severe eating disorders: a response to Dr Ayton	16
There is nothing as inconsistent as the OSFED diagnostic criteria	16
The future of phage therapy in the USA	16
Copy number alterations: a catastrophic orchestration of the breast cancer genome	16
Dysfunctional tRNA reprogramming and codon-biased translation in cancer	16
Repurposing of microbial proteins as new-generation therapeutic agents for biomedical applications	16