OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Molecular Medicine is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives	418
Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies	268
G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies	182
Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease	169
Impact of the Natural Compound Urolithin A on Health, Disease, and Aging	168
Cell-Free DNA and Apoptosis: How Dead Cells Inform About the Living	150
Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome	143
Ferroptosis in the tumor microenvironment: perspectives for immunotherapy	139
Liquid Biopsy of Methylation Biomarkers in Cell-Free DNA	126
The Gut Microbiota: Emerging Evidence in Autoimmune Diseases	118
Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis	108
Reducing Senescent Cell Burden in Aging and Disease	100
Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer’s Disease	96
Cell-to-Cell Transmission of Tau and α-Synuclein	93
Metabolic Pathways That Control Skin Homeostasis and Inflammation	90
Enhancers in disease: molecular basis and emerging treatment strategies	81
Ferroptosis in Parkinson’s disease: glia–neuron crosstalk	81
Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases	80
Antibiotic Resistance by Enzymatic Modification of Antibiotic Targets	72
Skin senescence: mechanisms and impact on whole-body aging	71
COVID-19 in pregnancy: implications for fetal brain development	68
Microbiota and sleep: awakening the gut feeling	65
Transcription Factor Inhibition: Lessons Learned and Emerging Targets	65
Extracellular matrix-based cancer targeting	65
NIRF Nanoprobes for Cancer Molecular Imaging: Approaching Clinic	62

The gut vascular barrier: a new player in the gut–liver–brain axis	60
NMDARs in Cell Survival and Death: Implications in Stroke Pathogenesis and Treatment	59
Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation	59
Fertility Preservation: The Challenge of Freezing and Transplanting Ovarian Tissue	59
Haptoglobin Therapeutics and Compartmentalization of Cell-Free Hemoglobin Toxicity	55
Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines	52
Preimplantation Genetic Testing for Aneuploidy – a Castle Built on Sand	51
Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective	51
Fibroblast Heterogeneity in Wound Healing: Hurdles to Clinical Translation	51
Activity-Based Diagnostics: An Emerging Paradigm for Disease Detection and Monitoring	50
Bacterial Peptidoglycan as a Driver of Chronic Brain Inflammation	49
HDL and Reverse Remnant-Cholesterol Transport (RRT): Relevance to Cardiovascular Disease	47
Mouth-Watering Results: Clinical Need, Current Approaches, and Future Directions for Salivary Gland Regeneration	47
Circular RNA translation: novel protein isoforms and clinical significance	45
Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia	45
Mitochondria as Therapeutic Targets in Transplantation	45
Assessing Toxicity with Human Cell-Based In Vitro Methods	43
Bacterial Peptidoglycans from Microbiota in Neurodevelopment and Behavior	43
Avoiding a Sticky Situation: Bypassing the Mucus Barrier for Improved Local Drug Delivery	43
The Ground Zero of Organismal Life and Aging	42
Journey to the Center of the Cell: Tracing the Path of AAV Transduction	42
Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis	42
Homeostatic maintenance of the lymphatic vasculature	41
Tooth Repair and Regeneration: Potential of Dental Stem Cells	41
Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment	41
Chemical Chaperones as Novel Drugs for Parkinson’s Disease	40
Multitissue Multiomics Systems Biology to Dissect Complex Diseases	39
FABP4: A New Player in Obesity-Associated Breast Cancer	39
Towards Advanced iPSC-based Drug Development for Neurodegenerative Disease	38
Therapeutic Modulation of RNA Splicing in Malignant and Non-Malignant Disease	38
Pro-cathepsin D, Prosaposin, and Progranulin: Lysosomal Networks in Parkinsonism	37
Staging of Alzheimer’s disease: past, present, and future perspectives	37
Polyhydroxyalkanoates and their advances for biomedical applications	36
Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases	36
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain health	35
Meet Your Stress Management Professionals: The Endocannabinoids	35
Leveraging Heterogeneity in Systemic Lupus Erythematosus for New Therapies	35
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?	35
Translational Neuroendocrinology of Human Skin: Concepts and Perspectives	33
The gut microbiome as a biomarker of differential susceptibility to SARS-CoV-2	33
Wound Repair, Scar Formation, and Cancer: Converging on Activin	32
Adeno-Associated Virus Vector for Central Nervous System Gene Therapy	32
Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing	31
Noncoding RNAs versus Protein Biomarkers in Cardiovascular Disease	31
Single extracellular vesicle analysis for early cancer detection	30
Extracellular Vesicles and Biomaterial Design: New Therapies for Cardiac Repair	30
PD-L1 regulation revisited: impact on immunotherapeutic strategies	29
Targeted Avenues for Cancer Treatment: The MEK5–ERK5 Signaling Pathway	29
Extinguishing the Embers: Targeting AML Metabolism	29
Data-Driven Modeling of Pregnancy-Related Complications	29

The Urgency of Justice in Research: Beyond COVID-19	28
Trained immunity-related vaccines: innate immune memory and heterologous protection against infections	28
Circadian molecular clock disruption in chronic pulmonary diseases	27
Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging	27
Intestinal mucus barrier: a missing piece of the puzzle in food allergy	27
Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation	27
Emergence of New Disease: How Can Artificial Intelligence Help?	27
JAK–STAT Targeting Offers Novel Therapeutic Opportunities in Sepsis	27
Cancer Surgery 2.0: Guidance by Real-Time Molecular Technologies	26
Type 2 Diabetes Mellitus Drugs for Alzheimer’s Disease: Current Evidence and Therapeutic Opportunities	26
Organoid models: assessing lung cell fate decisions and disease responses	26
Clinical Potential of Kisspeptin in Reproductive Health	25
The Centrosome Linker and Its Role in Cancer and Genetic Disorders	25
TLR2 as a Therapeutic Target in Bacterial Infection	25
Can’t handle the stress? Mechanobiology and disease	25
AAV capsid design: A Goldilocks challenge	25
Vaccination against Allergy: A Paradigm Shift?	24
Influenza A Viruses: Understanding Human Host Determinants	24
Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?	24
Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology	23
The COVID-19 Pandemic from an Ophthalmologist’s Perspective	23
PD-L1 and B7-1 Cis-Interaction: New Mechanisms in Immune Checkpoints and Immunotherapies	23
Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors	23
It’s in Our Blood: A Glimpse of Personalized Medicine	23
Sirtuins: To Be or Not To Be in Diabetic Cardiomyopathy	23
The physiology of bilirubin: health and disease equilibrium	23
Considering the Immune System during Fecal Microbiota Transplantation for Clostridioides difficile Infection	23
Therapeutic Approaches in Facioscapulohumeral Muscular Dystrophy	22
Molecular pathology of rare progeroid diseases	22
Therapeutic potential of interleukin-2 in autoimmune diseases	22
Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging	21
T Cells as Guardians of Pain Resolution	21
First Trial of CRISPR-Edited T cells in Lung Cancer	20
Moyamoya disease emerging as an immune-related angiopathy	20
Exposing the role of metals in neurological disorders: a focus on manganese	20
Genetic and Genomic Mechanisms of Primary Aldosteronism	20
Strategies of pluripotent stem cell-based therapy for retinal degeneration: update and challenges	20
Organoid technologies for the study of intestinal microbiota–host interactions	20
Topical Microbial Therapeutics against Respiratory Viral Infections	20
Breakthroughs and bottlenecks in autophagy research	20
Treatment and Prevention of Neurocristopathies	19
FSP1: a key regulator of ferroptosis	19
Understanding human health through metatranscriptomics	19
New insights into vitamin K biology with relevance to cancer	19
Adolescent PCOS: a postpubertal central obesity syndrome	19
Post-Transcriptional Regulation in Skeletal Muscle Development, Repair, and Disease	19
Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance	18
Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines	18
Breakthroughs and Bottlenecks in Microbiome Research	18
Pathogenic associations between oral and gastrointestinal diseases	18
Mislocalisation of Activated Receptor Tyrosine Kinases – Challenges for Cancer Therapy	18
mRNA therapeutics: beyond vaccine applications	18
A map of the altered glioma metabolism	18
Role and therapeutic implications of protein glycosylation in neuroinflammation	18
Adenoviruses in medicine: innocuous pathogen, predator, or partner	17
Targeting synaptic plasticity in schizophrenia: insights from genomic studies	17
IBD disease-modifying therapies: insights from emerging therapeutics	17
Historical Perspective of Clinical Nano and Microparticle Formulations for Delivery of Therapeutics	17
The multifaceted therapeutic value of targeting ATP-citrate lyase in atherosclerosis	17
Redefining Microglial Identity in Health and Disease at Single-Cell Resolution	17
Linking liver metabolic and vascular disease via bile acid signaling	16
ERα in the Control of Mitochondrial Function and Metabolic Health	16
Cancer driver mutations: predictions and reality	16
N6-methyladenosine-mediated gene regulation and therapeutic implications	16
Blocking Signalopathic Events to Treat Cerebral Cavernous Malformations	16
Role of inflammasomes in HIV-1 infection and treatment	16
Maternal obesity: new placental paradigms unfolded	16
Multivalent Probes in Molecular Imaging: Reality or Future?	16
Harnessing Therapeutic IgE Antibodies to Re-educate Macrophages against Cancer	16
Clock-modulated checkpoints in time-restricted eating	16
Predicting and Overcoming Taxane Chemoresistance	16
Ectopic Lymphoid Organs and Immune-Mediated Diseases: Molecular Basis for Pharmacological Approaches	16
Priming the Proteasome to Protect against Proteotoxicity	16
Bridging rapid and sustained antidepressant effects of ketamine	16