OOIR: Observatory of International Research

Papers

(The TQCC of BMC Biotechnology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Improvement and prediction of the extraction parameters of lupeol and stigmasterol metabolites of Melia azedarach with response surface methodology	60
Simplified cloning and isolation of peptides from “sandwiched” SUMO-peptide-intein fusion proteins	40
Identification of a novel fully human anti-toxic shock syndrome toxin (TSST)-1 single-chain variable fragment antibody averting TSST-1-induced mitogenesis and cytokine secretion	39
Parabacteroides distasonis promotes CXCL9 secretion of tumor-associated macrophages and enhances CD8+T cell activity to trigger anti-tumor immunity against anti-PD-1 treatment in non-small cell lung c	38
Optimized zymogram protocol from 3D spheroid cultures to study MMP-2 and -9 activities in tumor cells	34
Biocompatibility and potential anticancer activity of gadolinium oxide (Gd2O3) nanoparticles against nasal squamous cell carcinoma	33
Maximizing lipid accumulation in Tetradesmus obliquus under heavy metal stress for sustainable biodiesel innovation	31
3D printing of Ceffe-infused scaffolds for tailored nipple-like cartilage development	31
The mechanism of degradation of alizarin red by a white-rot fungus Trametes gibbosa	29
Enzymatic degradation is an effective means to reduce aflatoxin contamination in maize	26
Reductive enzymatic dynamic kinetic resolution affording 115 g/L (S)-2-phenylpropanol	24
Synergistic effect of zinc oxide-cinnamic acid nanoparticles for wound healing management: in vitro and zebrafish model studies	23
Biosafety and pharmacokinetic characteristics of polyethylene pyrrolidone modified nano selenium in rats	23
Transgenic Arabidopsis thaliana plants expressing bacterial γ-hexachlorocyclohexane dehydrochlorinase LinA	20
Electrospun PCL membranes for localized drug delivery and bone regeneration	20
Rice yellow mottle virus is a suitable amplicon vector for an efficient production of an anti-leishmianiasis vaccine in Nicotiana benthamiana leaves	19
Evaluating the anticancer efficacy of Chara vulgaris ethanolic extract and selenium nanoformulation in Ehrlich carcinoma mice: role of autophagy and apoptosis	18
Fusarium verticillioides pigment: production, response surface optimization, gamma irradiation and encapsulation studies	18
Biochemical characterization and insights into the potency of the acidic Aspergillus niger NRC114 purified α-galactosidase in removing raffinose family oligosaccharides from soymilk yogurt	17
Highly multiplexed targeted sequencing strategy for infectious disease surveillance	17
Fabrication and characterization of metformin-loaded PLGA/Collagen nanofibers for modulation of macrophage polarization for tissue engineering and regenerative medicine	17
Optimization of lipase production using fungal isolates from oily residues	17
Comparison of vector elements and process conditions in transient and stable suspension HEK293 platforms using SARS-CoV-2 receptor binding domain as a model protein	17
A new mRNA structure prediction based approach to identifying improved signal peptides for bone morphogenetic protein 2	16
Chitosan nano-formulation enhances stability and bactericidal activity of the lytic phage HK6	15

Soft sensor modeling method for Pichia pastoris fermentation process based on substructure domain transfer learning	15
Purification and characterization of soluble recombinant Crimean-Congo hemorrhagic fever virus glycoprotein Gc expressed in mammalian 293F cells	15
Generation of a recombinant antibody for sensitive detection of Pseudomonas aeruginosa	14
Newly designed curcumin-loaded hybrid nanoparticles: a multifunctional strategy for combating oxidative stress, inflammation, and infections to accelerate wound healing and tissue regeneration	14
The ESRP1 promoter reporter can function as an in vivo sensor of DNA methyltransferase inhibition	13
One-step fermentation for producing xylo-oligosaccharides from wheat bran by recombinant Escherichia coli containing an alkaline xylanase	13
Anti-inflammatory potential of aspergillus unguis SP51-EGY: TLR4-dependent effects & chemical diversity via Q-TOF LC-HRMS	12
Molecular and agro-morphological characterization of new barley genotypes in arid environments	12
Central position of histidine in the sequence of designed alternating polarity peptides enhances pH-responsive assembly with DNA	12
A critical role for erythropoietin on vagus nerve Schwann cells in intestinal motility	12
A novel allogeneic acellular matrix scaffold for porcine cartilage regeneration	11
Isolation and identification of antifungal, antibacterial and nematocide agents from marine bacillus gottheilii MSB1	11
Gene cloning and molecular characterization of a thermostable chitosanase from Bacillus cereus TY24	11
Validation and calibration of a novel GEM biosensor for specific detection of Cd2+, Zn2+, and Pb2+	10
ECM-mimetic, NSAIDs loaded thermo-responsive, immunomodulatory hydrogel for rheumatoid arthritis treatment	10
Ferula latisecta gels for synthesis of zinc/silver binary nanoparticles: antibacterial effects against gram-negative and gram-positive bacteria and physicochemical characteristics	10
Derivation of a novel antimicrobial peptide from the Red Sea Brine Pools modified to enhance its anticancer activity against U2OS cells	10
An engineered hypoxia-response promoter for human umbilical cord-derived mesenchymal stem cell-based therapeutics	10
A magnetic solid phase chemiluminescent immunoassay for quantification of Cystatin C in human serum	10
Saccharification and co-fermentation of lignocellulosic biomass by a cockroach-gut bacterial symbiont and yeast cocktail for bioethanol production	10
Efficient delivery of a large-size Cas9-EGFP vector in porcine fetal fibroblasts using a Lonza 4D-Nucleofector system	10
Aripiprazole-loaded niosome/chitosan-gold nanoparticles for breast cancer chemo-photo therapy	10
A copper switch for inducing CRISPR/Cas9-based transcriptional activation tightly regulates gene expression in Nicotiana benthamiana	10
Unlocking the antioxidant and antibacterial potential of exopolysaccharides produced by endophytic fungi (Aspergillus fumigatus and Preussia isabellae) isolated from Tanzania’s mangroves	10
Aspergillus terreus camptothecin-sodium alginate/titanium dioxide nanoparticles as a novel nanocomposite with enhanced compatibility and anticancer efficiency in vivo	10
High-performance internal circulation anaerobic granular sludge reactor for cattle slaughterhouse wastewater treatment and simultaneous biogas production	9
Green and environmentally friendly synthesis of silver nanoparticles with antibacterial properties from some medicinal plants	9
An efficient and specific CRISPR-Cas9 genome editing system targeting soybean phytoene desaturase genes	9
Establishment of an indirect ELISA antibody detection method based on the stable expression of LSDV P32 protein in CHO-K1 cells	9
Fabrication of apigenin and adenosine-loaded nanoparticles against doxorubicin-induced myocardial infarction by reducing inflammation and oxidative stress	9
Dexamethasone-boosted mesenchymal stem cell secretome: insight into hepatic protection	9
Organosolv-derived lipids from hemicellulose and cellulose, and pre-extracted tannins as additives upon hydrothermal liquefaction (HTL) of spruce bark lignins to bio-oil	8
An anti-idiotypic single domain antibody as Cry2Aa toxin mimotope and analysis of its binding region through molecular docking	8
Development of a CHO cell line for stable production of recombinant antibodies against human MMP9	8
Utilizing non-clonal CHO cell derived materials for preclinical studies of complex molecules	8
A novel starch-active lytic polysaccharide monooxygenase discovered with bioinformatics screening and its application in textile desizing	8
Rescue of an enterotropic Newcastle disease virus strain ZM10 from cloned cDNA and stable expressing an inserted foreign gene	8
Enhancing the biotransformation of progesterone to the anticancer compound testololactone by Penicillium chrysogenum Ras3009: kinetic modelling and efficiency maximization	8
Antifungal efficacy of Citrusfusion mediated silver nanoparticles in Candida species	8
Exploring the microbial diversity and characterization of cellulase and hemicellulase genes in goat rumen: a metagenomic approach	7
Assessment of the bioactive compounds in gamma irradiated stevia (Stevia rebaudiana Bertoni) leaves	7
Coupling fermentation of glutamic acid and γ-polyglutamic acid and preparation of poly(amino acid) superabsorbent polymers	7
An engineered self-cleavage fusion system for the production of chimaera spider silk proteins	7
Development of a chemically defined medium for Paenibacillus polymyxa by parallel online monitoring of the respiration activity in microtiter plates	7
Synthesis and evaluation of nanosized aluminum MOF encapsulating Umbelliferon: assessing antioxidant, anti-inflammatory, and wound healing potential in an earthworm model	7
Efficient extraction and antioxidant activity of polyphenols from Antrodia cinnamomea	7
Optimization of culture conditions for HBV-specific T cell expansion in vitro from chronically infected patients	7
Comparison of active site mutations at subsite + 2 of Anoxybacillus ayderensis A9 β-glucosidase for hydrolysis of pNPG and polydatin	7
Orange peel-mediated synthesis of silver nanoparticles with antioxidant and antitumor activities	7
Dual release of daptomycin and BMP-2 from a composite of β-TCP ceramic and ADA gelatin	7

Integration of ZnO nanorods with silver ions by a facile co-precipitation for antimicrobial, larvicidal, and ovicidal activity	7
Bioconversion of wild Ipomoea pes-caprae and Suaeda fruticosa biomass: a novel application of thermostable xylanase from Neobacillus sedimentimangrovi	7
Induction of antimicrobial, antioxidant metabolites production by co-cultivation of two red-sea-sponge-associated Aspergillus sp. CO2 and Bacillus sp. COBZ21	6
Design, synthesis, and biological evaluation of Osimertinib–Cy7 (OSA-Cy7) conjugate as potential theranostic agent targeting activating EGFR mutations	6
Effects of solid lipid nanocarrier containing methyl urolithin A by coating folate-bound chitosan and evaluation of its anti-cancer activity	6
Scientific and technological challenges of recombinant egg protein production	6
Oleic acid based experimental evolution of Bacillus megaterium yielding an enhanced P450 BM3 variant	6
Assessment of biochar filter application in improving chromium stress tolerance and plant physiology in Chinese cabbage (Brassica rapa) under a flow-through water setup	6
Development of a chemiluminescence assay for tissue plasminogen activator inhibitor complex and its applicability to gastric cancer	6
Preparation and characterization of propolis reinforced eggshell membrane/ GelMA composite hydrogel for biomedical applications	6
Choosing an appropriate somatic embryogenesis medium of carrot (Daucus carota L.) by data mining technology	6
Influence of low-intensity artificial light on the fatty acid profile of the biotechnologically important culinary mushroom Pleurotus eryngii in vitro	6
Research on the targeted improvement of the yield of a new VB12-producing strain, Ensifer adhaerens S305, based on genomic and transcriptomic analysis	6
Introduction of loxP sites by electroporation in the mouse genome; a simple approach for conditional allele generation in complex targeting loci	6
rocF affects the production of tetramethylpyrazine in fermented soybeans with Bacillus subtilis BJ3-2	6
Identification, expression, and purification of DNA cytosine 5-methyltransferases with short recognition sequences	6
The transcriptional factor Clr-5 is involved in cellulose degradation through regulation of amino acid metabolism in Neurospora crassa	6
Prediction and optimization of indirect shoot regeneration of Passiflora caerulea using machine learning and optimization algorithms	6
Enhanced extracellular production of Coprinopsis cinerea laccase Lcc9 in Aspergillus niger by gene expression cassette and bioprocess optimization	6