OOIR: Observatory of International Research

Papers

(The TQCC of BMC Biotechnology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Improvement and prediction of the extraction parameters of lupeol and stigmasterol metabolites of Melia azedarach with response surface methodology	55
Identification of a novel fully human anti-toxic shock syndrome toxin (TSST)-1 single-chain variable fragment antibody averting TSST-1-induced mitogenesis and cytokine secretion	44
Optimization of expression, purification and secretion of functional recombinant human growth hormone in Escherichia coli using modified staphylococcal protein a signal peptide	36
Simplified cloning and isolation of peptides from “sandwiched” SUMO-peptide-intein fusion proteins	33
Parabacteroides distasonis promotes CXCL9 secretion of tumor-associated macrophages and enhances CD8+T cell activity to trigger anti-tumor immunity against anti-PD-1 treatment in non-small cell lung c	33
3D printing of Ceffe-infused scaffolds for tailored nipple-like cartilage development	31
Optimized zymogram protocol from 3D spheroid cultures to study MMP-2 and -9 activities in tumor cells	29
Maximizing lipid accumulation in Tetradesmus obliquus under heavy metal stress for sustainable biodiesel innovation	29
Enzymatic degradation is an effective means to reduce aflatoxin contamination in maize	28
Genome-scale insights into the metabolic versatility of Limosilactobacillus reuteri	27
Reductive enzymatic dynamic kinetic resolution affording 115 g/L (S)-2-phenylpropanol	27
Biosafety and pharmacokinetic characteristics of polyethylene pyrrolidone modified nano selenium in rats	26
The mechanism of degradation of alizarin red by a white-rot fungus Trametes gibbosa	23
Biocompatibility and potential anticancer activity of gadolinium oxide (Gd2O3) nanoparticles against nasal squamous cell carcinoma	22
Synergistic effect of zinc oxide-cinnamic acid nanoparticles for wound healing management: in vitro and zebrafish model studies	21
Lentiviral CRISPR-guided RNA library screening identified Adam17 as an upstream negative regulator of Procr in mammary epithelium	20
Electrospun PCL membranes for localized drug delivery and bone regeneration	19
Transgenic Arabidopsis thaliana plants expressing bacterial γ-hexachlorocyclohexane dehydrochlorinase LinA	17
Rice yellow mottle virus is a suitable amplicon vector for an efficient production of an anti-leishmianiasis vaccine in Nicotiana benthamiana leaves	17
Optimization of lipase production using fungal isolates from oily residues	16
Fabrication and characterization of metformin-loaded PLGA/Collagen nanofibers for modulation of macrophage polarization for tissue engineering and regenerative medicine	16
Comparison of vector elements and process conditions in transient and stable suspension HEK293 platforms using SARS-CoV-2 receptor binding domain as a model protein	16
Highly multiplexed targeted sequencing strategy for infectious disease surveillance	16
Fusarium verticillioides pigment: production, response surface optimization, gamma irradiation and encapsulation studies	16
Chitosan nano-formulation enhances stability and bactericidal activity of the lytic phage HK6	15

Biochemical characterization and insights into the potency of the acidic Aspergillus niger NRC114 purified α-galactosidase in removing raffinose family oligosaccharides from soymilk yogurt	15
A new mRNA structure prediction based approach to identifying improved signal peptides for bone morphogenetic protein 2	14
Purification and characterization of soluble recombinant Crimean-Congo hemorrhagic fever virus glycoprotein Gc expressed in mammalian 293F cells	14
Soft sensor modeling method for Pichia pastoris fermentation process based on substructure domain transfer learning	14
One-step fermentation for producing xylo-oligosaccharides from wheat bran by recombinant Escherichia coli containing an alkaline xylanase	13
Generation of a recombinant antibody for sensitive detection of Pseudomonas aeruginosa	13
Molecular and agro-morphological characterization of new barley genotypes in arid environments	12
Anti-inflammatory potential of aspergillus unguis SP51-EGY: TLR4-dependent effects & chemical diversity via Q-TOF LC-HRMS	12
A critical role for erythropoietin on vagus nerve Schwann cells in intestinal motility	12
Recombinant laccase rPOXA 1B real-time, accelerated and molecular dynamics stability study	12
Aripiprazole-loaded niosome/chitosan-gold nanoparticles for breast cancer chemo-photo therapy	11
A novel allogeneic acellular matrix scaffold for porcine cartilage regeneration	11
Gene cloning and molecular characterization of a thermostable chitosanase from Bacillus cereus TY24	11
Isolation and identification of antifungal, antibacterial and nematocide agents from marine bacillus gottheilii MSB1	11
A copper switch for inducing CRISPR/Cas9-based transcriptional activation tightly regulates gene expression in Nicotiana benthamiana	11
ECM-mimetic, NSAIDs loaded thermo-responsive, immunomodulatory hydrogel for rheumatoid arthritis treatment	10
A magnetic solid phase chemiluminescent immunoassay for quantification of Cystatin C in human serum	10
Efficient delivery of a large-size Cas9-EGFP vector in porcine fetal fibroblasts using a Lonza 4D-Nucleofector system	10
Validation and calibration of a novel GEM biosensor for specific detection of Cd2+, Zn2+, and Pb2+	10
Ferula latisecta gels for synthesis of zinc/silver binary nanoparticles: antibacterial effects against gram-negative and gram-positive bacteria and physicochemical characteristics	10
Derivation of a novel antimicrobial peptide from the Red Sea Brine Pools modified to enhance its anticancer activity against U2OS cells	10
Saccharification and co-fermentation of lignocellulosic biomass by a cockroach-gut bacterial symbiont and yeast cocktail for bioethanol production	9
High-performance internal circulation anaerobic granular sludge reactor for cattle slaughterhouse wastewater treatment and simultaneous biogas production	9
Enhancing the biotransformation of progesterone to the anticancer compound testololactone by Penicillium chrysogenum Ras3009: kinetic modelling and efficiency maximization	9
Fabrication of apigenin and adenosine-loaded nanoparticles against doxorubicin-induced myocardial infarction by reducing inflammation and oxidative stress	9
Rescue of an enterotropic Newcastle disease virus strain ZM10 from cloned cDNA and stable expressing an inserted foreign gene	9
Development of a CHO cell line for stable production of recombinant antibodies against human MMP9	9
An efficient and specific CRISPR-Cas9 genome editing system targeting soybean phytoene desaturase genes	9
Aspergillus terreus camptothecin-sodium alginate/titanium dioxide nanoparticles as a novel nanocomposite with enhanced compatibility and anticancer efficiency in vivo	9
Green and environmentally friendly synthesis of silver nanoparticles with antibacterial properties from some medicinal plants	9
Organosolv-derived lipids from hemicellulose and cellulose, and pre-extracted tannins as additives upon hydrothermal liquefaction (HTL) of spruce bark lignins to bio-oil	8
Antifungal efficacy of Citrusfusion mediated silver nanoparticles in Candida species	8
The study of laccase immobilization optimization and stability improvement on CTAB-KOH modified biochar	8
A novel starch-active lytic polysaccharide monooxygenase discovered with bioinformatics screening and its application in textile desizing	8
Utilizing non-clonal CHO cell derived materials for preclinical studies of complex molecules	8
Coupling fermentation of glutamic acid and γ-polyglutamic acid and preparation of poly(amino acid) superabsorbent polymers	8
Synthesis and evaluation of nanosized aluminum MOF encapsulating Umbelliferon: assessing antioxidant, anti-inflammatory, and wound healing potential in an earthworm model	8
Insights from molecular docking and molecular dynamics on the potential of vitexin as an antagonist candidate against lipopolysaccharide (LPS) for microglial activation in neuroinflammation	8
Integration of ZnO nanorods with silver ions by a facile co-precipitation for antimicrobial, larvicidal, and ovicidal activity	7
Choosing an appropriate somatic embryogenesis medium of carrot (Daucus carota L.) by data mining technology	7
Efficient extraction and antioxidant activity of polyphenols from Antrodia cinnamomea	7
Enhanced extracellular production of Coprinopsis cinerea laccase Lcc9 in Aspergillus niger by gene expression cassette and bioprocess optimization	7
The transcriptional factor Clr-5 is involved in cellulose degradation through regulation of amino acid metabolism in Neurospora crassa	7
Effects of solid lipid nanocarrier containing methyl urolithin A by coating folate-bound chitosan and evaluation of its anti-cancer activity	7
Influence of low-intensity artificial light on the fatty acid profile of the biotechnologically important culinary mushroom Pleurotus eryngii in vitro	7
Oleic acid based experimental evolution of Bacillus megaterium yielding an enhanced P450 BM3 variant	7
Orange peel-mediated synthesis of silver nanoparticles with antioxidant and antitumor activities	7
Development of a chemically defined medium for Paenibacillus polymyxa by parallel online monitoring of the respiration activity in microtiter plates	7
Prediction and optimization of indirect shoot regeneration of Passiflora caerulea using machine learning and optimization algorithms	7
Introduction of loxP sites by electroporation in the mouse genome; a simple approach for conditional allele generation in complex targeting loci	7

Bioconversion of wild Ipomoea pes-caprae and Suaeda fruticosa biomass: a novel application of thermostable xylanase from Neobacillus sedimentimangrovi	7
Exploring the microbial diversity and characterization of cellulase and hemicellulase genes in goat rumen: a metagenomic approach	7
Dual release of daptomycin and BMP-2 from a composite of β-TCP ceramic and ADA gelatin	7
Optimization of culture conditions for HBV-specific T cell expansion in vitro from chronically infected patients	7