Expert Opinion on Therapeutic Targets

Article	Citations
Assessing platelet-derived extracellular vesicles for potential as therapeutic targets in cardiovascular diseases	102
Endothelial dysfunction: a therapeutic target in bacterial sepsis?	56
Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy	46
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?	43
Targeting ALK receptors in non-small cell lung cancer: what is the road ahead?	41
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer	35
HIV Pol: does it offer therapeutic targets for HIV?	35
Retinal vein occlusion: drug targets and therapeutic implications	33
Fatty liver disease: time to target CCR5?	33
Ubiquitin-specific protease 7 (USP7): an emerging drug target for cancer treatment	33
Novel therapeutic targets for diabetes-related wounds or ulcers: an update on preclinical and clinical research	31
Emerging therapeutic targets for narcolepsy	30
Targeting VCAM-1: a therapeutic opportunity for vascular damage	29
IL-36: a therapeutic target for ulcerative colitis?	28
Dyskinesia and Parkinson’s disease: animal model, drug targets, and agents in preclinical testing	28
An update on novel pharmacological agents for primary sclerosing cholangitis	27
Glucocorticoid receptors participate in epilepsy in FCDII patients and MP model rats: A potential therapeutic target for epilepsy in patients with focal cortical dysplasia II (FCDII)	27
Glucose-6-phosphate dehydrogenase: a therapeutic target for ovarian cancer	24
lncRNAs: potential therapeutic targets and biomarkers for pancreatic cancer?	24
Advances in cerebellar disorders: pre-clinical models, therapeutic targets, and challenges	24
Tolperisone induces UPR-mediated tumor inhibition and synergizes with proteasome inhibitor and immunotherapy by targeting LSD1	24
Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential	24
The ATP-sensitive potassium channel: a therapeutic target for neurodegeneration?	24
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA	24
Mitochondria makeover: unlocking the path to healthy longevity	23

Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy	23
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications	22
Targeted therapeutic strategies for the kidney	21
Gateway reflexes are neural circuits that establish the gateway of immune cells to regulate tissue specific inflammation	21
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?	21
Understanding the role of galectins toward influenza A virus infection	21
Targeting the CTLA-4/B7 axes in glioblastoma: preclinical evidence and clinical interventions	21
Druggable genes for therapeutic targeting in PTH signaling for osteoporosis	21
Powering down the mitochondrial LonP1 protease: a novel strategy for anticancer therapeutics	21
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines	20
Mitochondrial permeability transition pore: a snapshot of a therapeutic target	20
Correction	20
OXPHOS-targeting drugs in oncology: new perspectives	20
Interleukin-18 in cancer immunology and immunotherapy	19
Can targeting the FGF23-αKlotho signaling system delay phosphate-driven organ damage?	18
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects	18
Human prion disease: molecular pathogenesis, and possible therapeutic targets and strategies	18
The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review	18
Pharmacological targeting of ECM homeostasis, fibroblast activation and invasion for the treatment of pulmonary fibrosis	17
An overview of novel antimicrobial carbonic anhydrase inhibitors	17
MET alterations and their impact on the future of non-small cell lung cancer (NSCLC) targeted therapies	17
Acute myeloid leukemia: therapeutic targeting of stem cells	16
Progress and challenges in glypican-3 targeting for hepatocellular carcinoma therapy	15
Galectin-3: therapeutic targeting in liver disease	15
TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2	15
Glycoproteins and longevity: an interview with Professor Gordan Lauc	15
Navigating the landscape of psoriasis therapy: novel targeted pathways and emerging trends	14
NF-κB-inducing kinase (NIK): an emerging therapeutic target in human disease	14
Aberrations of DNA repair pathways in prostate cancer: a cornerstone of precision oncology	14
Can we suppress chronic systemic inflammation and postpone age-related diseases by targeting the IgG glycome?	14
miR-26a-5p restoration via EZH2 silencing blocks the IL-6/STAT3 axis to repress the growth of prostate cancer	14
Mast cell chymase-1 and tryptases: therapeutic targets for COPD?	14
Tumor cells-derived extracellular vesicles carry circ_0064516 competitively inhibit microRNA-6805-3p and promote cervical cancer angiogenesis and tumor growth	13
Combining rejuvenation interventions in rodents: a milestone in biomedical gerontology whose time has come	12
Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway	12
Chemokine signaling in tumors: potential role of CXC chemokines and their receptors as glioblastoma therapeutic targets	11
Repurposing fluoxetine to treat lymphocytic leukemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction	11
Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging	11
Targeting mucosal healing in Crohn’s disease: efficacy of novel pathways and therapeutic targets	11
The mineralocorticoid receptor signal could be a new molecular target for the treatment of diabetic retinal complication	11
Preclinical target validation for non-addictive therapeutics development for pain	11
TRPC3: how current mechanistic understanding provides a basis for therapeutic targeting	11
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases	11
Axial spondyloarthritis: emerging drug targets	11
Emerging therapeutic targets for osteoarthritis	10
Casein Kinase II exacerbates rheumatoid arthritis via promoting Th1 and Th17 cell inflammatory responses	10
Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications	10
TGF-β as a therapeutic target in the infarcted and failing heart: cellular mechanisms, challenges, and opportunities	9
The role of the sigma-1 receptor in neuroprotection: Comment on Nrf-2 as a therapeutic target in ischemic stroke	9
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement	9

Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?	9
Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets	9
The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting	9
Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing	9
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets	9
Triple-negative breast cancer drug resistance, durable efficacy, and cure: how advanced biological insights and emerging drug modalities could transform progress	9
Fatty acid-mediated signaling as a target for developing type 1 diabetes therapies	9
Unraveling therapeutic targets in acute myeloid leukemia through multiplexed genome editing CRISPR screening	9
Major depressive disorder (mdd): emerging immune targets at preclinical level	9
Leucine-rich repeat kinase 2 (LRRK2): an update on the potential therapeutic target for Parkinson’s disease	9
Lipid metabolism in malignant tumor brain metastasis: reprogramming and therapeutic potential	9
Modulating multidrug resistance to drug-based antitumor therapies through NF-κB signaling pathway: mechanisms and perspectives	9
Guillain–Barré syndrome: immunopathogenesis and therapeutic targets	9
Renal ciliopathies: promising drug targets and prospects for clinical trials	8
NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): seven years between lights and shadows	8
Toxoplasma gondii infection: novel emerging therapeutic targets	8
PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date	8
Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder	8
Targeting inflammasome complexes as a novel therapeutic strategy for mood disorders	8
The role of immune response in the pathogenesis of idiopathic pulmonary fibrosis: far beyond the Th1/Th2 imbalance	8
Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors?	8
The mechanisms and therapeutic targets of ferroptosis in cancer	8
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression	8
Targeting the EGFR signaling pathway in cancer therapy: What’s new in 2023?	8
VPS35 or retromer as a potential target for neurodegenerative disorders: barriers to progress	8
Cholangiocarcinoma: what are the most valuable therapeutic targets – cancer-associated fibroblasts, immune cells, or beyond T cells?	8
Hepatitis B virus: promising drug targets and therapeutic implications	8
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies	8
Targeting SHP2 phosphatase in hematological malignancies	8
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers	8
Microglia as therapeutic targets after neurological injury: strategy for cell therapy	8
Arenobufagin induces cell apoptosis by modulating the cell cycle regulator claspin and the JNK pathway in nasopharyngeal carcinoma cells	8
Hypoplastic left heart syndrome (HLHS): molecular pathogenesis and emerging drug targets for cardiac repair and regeneration	8
Spotlight on liver macrophages for halting injury and progression in nonalcoholic fatty liver disease	7
Novel and emerging targets for cholangiocarcinoma progression: therapeutic implications	7
Modulations of ferroptosis in lung cancer therapy	7
Can we target insulin signalling for cognition therapeutics?	7
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?	7
Therapeutic potential of RUNX1 and RUNX2 in bone metastasis of breast cancer	7
Early clinical and pre-clinical therapy development in Nemaline myopathy	7
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders	7
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study	7
A short report on NGM282/aldafermin for the treatment of nonalcoholic steatohepatitis (NASH)	7
Signal peptide peptidase: a potential therapeutic target for parasitic and viral infections	7
Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity	6
Epigenetic regulatory mechanisms of histone acetylation in the treatment of cutaneous squamous cell carcinoma	6
PI3K and tankyrase inhibitors as therapeutic targets in colorectal cancer	6
The endocannabinoid system as a therapeutic target in neuropathic pain: a review	6
Novel therapeutic perspectives for crescentic glomerulonephritis through targeting parietal epithelial cell activation and proliferation	6
Tackling retinal ganglion cell apoptosis in glaucoma: role of adenosine receptors	6
Innovations in treating acute graft-versus-host disease: a review of preclinical targets and strategies	6
Kv1.3 in the spotlight for treating immune diseases	6
Epigenetic regulation of immune cells in systemic lupus erythematosus: insight from chromatin accessibility	6
Exploring PKG signaling as a therapeutic avenue for pressure overload, ischemia, and HFpEF	6
The role of Nrf2 in immune cells and inflammatory autoimmune diseases: a comprehensive review	6
Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases	6
MT1-MMP – A potential drug target for the management of the obesity	6
Current challenges in the discovery of treatments against Mayaro fever	6
An update on the development on tubulin inhibitors for the treatment of solid tumors	6
Duchenne cardiomyopathy: targeting ROS and NOX4 as a promising therapeutic strategy	6
Glycometabolic rearrangements–aerobic glycolysis in pancreatic ductal adenocarcinoma (PDAC): roles, regulatory networks, and therapeutic potential	6
Leveraging AI to identify dual-purpose aging and disease targets	5
Focusing on oligomeric tau as a therapeutic target in Alzheimer’s disease and other tauopathies	5
Therapeutic approaches targeting oncogenic proteins in myeloid leukemia: challenges and perspectives	5
NTRK fusions in colorectal cancer: clinical meaning and future perspective	5
Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level	5
Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy	5
MDA-9/Syntenin as a therapeutic cancer metastasis target: current molecular and preclinical understanding	5
Cytokines of the interleukin-6 family as emerging targets in inflammatory bowel disease	5
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	5
A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function	5
The brain heme oxygenase/biliverdin reductase system as a target in drug research and development	5
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer	5
Sirtuins as therapeutic targets in diabetes	5
Targeting RUNX1 in acute myeloid leukemia: preclinical innovations and therapeutic implications	5
The potential of multimolecular G-quadruplex structures for targeted treatment of Amyotrophic Lateral Sclerosis	5
XBP1 as a novel molecular target to attenuate drug resistance in hepatocellular carcinoma	5
How will the identification and therapeutic intervention of genetic targets in oncology evolve for future therapy?	5
Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness	5
Targeting cyclin-dependent kinases in rheumatoid arthritis and psoriasis – a review of current evidence	5

Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies	5
Potential of αvβ6 and αvβ1 integrin inhibition for treatment of idiopathic pulmonary fibrosis	5
Therapeutic application of GLP-1 and GIP receptor agonists in Parkinson’s disease	5
Unlocking the potential of melanotransferrin (CD228): implications for targeted drug development and novel therapeutic avenues	5
Emerging therapeutic targets for epilepsy: preclinical insights	4
Targeting protein clearance pathways in GBA1-associated Parkinson disease	4
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential	4
Enhancer of zeste homolog 2 (EZH2) in endocrine tumors: current knowledge and future directions	4
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2	4
The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?	4
CD36 as a target for metabolic modulation therapy in cardiac disease	4
Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations	4
Redox-sensitive TRP channels: a promising pharmacological target in chemotherapy-induced peripheral neuropathy	4
TAR DNA-binding protein of 43 kDa (TDP-43) and amyotrophic lateral sclerosis (ALS): a promising therapeutic target	4
Advances in molecular therapies for targeting pathophysiology in spinal cord injury	4
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets	4
Targeting HIF-1 for prostate cancer: a synthesis of preclinical evidence	4
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age	3
Implications of recent molecular achievements in early diagnosis and precision treatments for primary CNS lymphoma	3
Uncovering key targets of success for immunotherapy in pancreatic cancer	3
Parasite and host kinases as targets for antimalarials	3
Potential therapeutic targets for Mpox: the evidence to date	3
Correspondence regarding: TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-2	3
Alternative antigen to defuse SARS-CoV-2 delta variant and its ensuing evolutionary lineage	3
Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy	3
Serotonin and valvular heart disease	3
Advantages and disadvantages of targeting senescent endothelial cells in cardiovascular and cerebrovascular diseases based on small extracellular vesicles	3
Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis	3
miR-181a : regulatory roles, cancer-associated signaling pathway disruptions, and therapeutic potential	3
Target potential of miRNAs in ulcerative colitis: what do we know?	3
Targeting fetal hemoglobin expression to treat β hemoglobinopathies	3
Neuromodulatory effects of SARS-CoV2 infection: Possible therapeutic targets	3
H3K27-altered diffuse midline glioma: a paradigm shifting opportunity in direct delivery of targeted therapeutics	3
Emerging therapeutic targets for sepsis	3
Shedding light on emerging therapeutic targets for chordoma	3
Taking the road less traveled – the therapeutic potential of CBP/β-catenin antagonists	3
Neuropathogenesis of HIV and emerging therapeutic targets	3
BRCA mutations in pancreatic cancer and progress in their targeting	3
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath	3
Type 1 diabetes: key drug targets and how they could influence future therapeutics	3