Expert Opinion on Therapeutic Targets

Article	Citations
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines	121
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA	60
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects	56
Mitochondrial permeability transition pore: a snapshot of a therapeutic target	55
Targeting transcription in neuroblastoma: focus on the core regulatory circuit	45
Interleukin-18 in cancer immunology and immunotherapy	40
CDK7 as a New therapeutic target in pancreatic and lung cancer: current evidence and future perspectives	40
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy	39
IL-36: a therapeutic target for ulcerative colitis?	37
Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications	33
Molecular basis for targeting TBK1 in CAR-T cell therapies for cancer	33
Glycoproteins and longevity: an interview with Professor Gordan Lauc	33
The membrane receptor CD44: roles in neurodegenerative diseases	33
Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing	32
The sigma–1 receptor: a mechanistically–informed therapeutic target for antidepressants	32
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement	31
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer	30
MDA-9/Syntenin as a therapeutic cancer metastasis target: current molecular and preclinical understanding	30
The potential of multimolecular G-quadruplex structures for targeted treatment of Amyotrophic Lateral Sclerosis	28
Current challenges in the discovery of treatments against Mayaro fever	26
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets	25
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study	25
Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy	24
Identification of target sites in the VHR (DUSP3) enzyme unlocking potential avenues for future sepsis treatment	24
Uncovering key targets of success for immunotherapy in pancreatic cancer	23

The challenges and potential of microRNA-based therapy for patients with liver failure syndromes and hepatocellular carcinoma	22
Clostridioides difficile: innovations in target discovery and potential for therapeutic success	22
Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis	21
KRAS mutations in colorectal cancer: impacts on tumor microenvironment and therapeutic implications	20
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath	20
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age	20
The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?	19
The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin	18
The trap becomes the target: molecular basis for targeted inhibition of neutrophil extracellular traps in the pre-metastatic niche	18
Progeria: a perspective on potential drug targets and treatment strategies	18
Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABAB R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model	18
Antibacterial carbonic anhydrase inhibitors targeting Vibrio cholerae enzymes	18
Esophageal cancer: emerging therapeutics	18
Novel signatures of prostate cancer progression and therapeutic resistance	18
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling	17
Promising therapeutic targets for the treatment of urine storage dysfunction: what’s the status?	17
RBM47 as a therapeutic target in selected human diseases	17
Targeting PRL phosphatases in hematological malignancies	17
Molecular pharmacology of multitarget cyclin-dependent kinase inhibitors in human colorectal carcinoma cells	17
What do we know about the renin angiotensin system and inflammatory bowel disease?	16
Targeting acid-sensing ion channels in glioblastoma: is there any therapeutic potential?	16
Atypical teratoid rhabdoid tumor (ATRT): disease mechanisms and potential drug targets	16
ULK1 as a therapeutic target in kidney diseases: Current perspective	16
Myocarditis: causes, mechanisms, and evolving therapies	16
Tenosynovial giant cell tumors (TGCT): molecular biology, drug targets and non-surgical pharmacological approaches	16
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications	15
Emerging therapeutic targets for anorexia nervosa	15
Granzyme B as a therapeutic target: an update in 2022	15
Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy	15
GDF15: a potential therapeutic target for type 1 diabetes	15
Sjögren’s syndrome: shedding light on emerging and key drug targets	15
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?	15
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update	15
Mitochondria makeover: unlocking the path to healthy longevity	14
What is the potential of formyl peptide receptor 1 (FPR1) as a therapeutic target in human disease?	14
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?	14
The contribution of fibronectin in epileptogenesis: therapeutic potential and mechanistic complexity	13
The mechanisms and therapeutic targets of ferroptosis in cancer	13
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies	13
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers	13
Metabolic hallmarks of trastuzumab resistance	13
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer	13
Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness	12
Unveiling the role of mineralocorticoid receptor antagonists in epilepsy: the intersection of seizures, stress, and neuroinflammation	12
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets	12
Leveraging AI to identify dual-purpose aging and disease targets	12
Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies	12
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression	12
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?	12
Rare tumors, real targets: patient-derived models for the discovery and validation of precision therapies	12

The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state	11
The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies	11
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders	11
Emerging therapeutic targets for epilepsy: preclinical insights	11
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2	11
An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models	11
Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level	11
Cellular role of CD93 and its potential as a future therapeutic target	11
TAR DNA-binding protein of 43 kDa (TDP-43) and amyotrophic lateral sclerosis (ALS): a promising therapeutic target	11
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment	11
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential	11
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	11
Epigenetic regulatory mechanisms of histone acetylation in the treatment of cutaneous squamous cell carcinoma	11
Shedding light on emerging therapeutic targets for chordoma	11
Considerations on the implementation of MAP4K4 inhibitors as cancer treatment	10
Targeting the TRPV1 pain pathway in osteoarthritis of the knee	10
ORF6, a repressor of the MHC class I pathway: new molecular target for SARS-CoV-2 drug discovery?	10
Ways of modulating GABA transporters to treat neurological disease	10
Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles	10
Restoring FXR expression as a novel treatment strategy in liver cancer and other liver disorders	9
Cardiac conduction diseases: understanding the molecular mechanisms to uncover targets for future treatments	9
Role of the P2Y12 receptor on thrombus formation and evolution in therapeutic strategies	9
Current strategies for targeting HPK1 in cancer and the barriers to preclinical progress	9
Emerging pathways yielding opportunities for future treatments in pancreatic ductal adenocarcinoma	9
Emerging drug targets for triple-negative breast cancer: a guided tour of the preclinical landscape	9
Potential therapeutic targets to prevent organ damage in chronic pulmonary sarcoidosis	9
Targeting the Tumor-Tumor Microenvironment Crosstalk	9
The potential for OGG1 inhibition to be a therapeutic strategy for pulmonary diseases	9
aMMP-8 point-of-care - diagnostic methods and treatment modalities in periodontitis and peri-implantitis	9
New therapeutic targets for endometrial cancer: a glimpse into the preclinical sphere	9
The emerging role of TIM-3 in colorectal cancer: a promising target for immunotherapy	9
Pharmacological targeting of ECM homeostasis, fibroblast activation and invasion for the treatment of pulmonary fibrosis	8
Emerging role for the Serum Response Factor (SRF) as a potential therapeutic target in cancer	8
The emerging role of Tetraspanin 32 in autoimmune diseases: from discovery to relevant theranostics?	8
The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review	8
Fatty liver disease: time to target CCR5?	8
Renal fibrosis as a hallmark of diabetic kidney disease: potential role of targeting transforming growth factor-beta (TGF-β) and related molecules	8
Gateway reflexes are neural circuits that establish the gateway of immune cells to regulate tissue specific inflammation	8
Acute myeloid leukemia: therapeutic targeting of stem cells	8
Can targeting the FGF23-αKlotho signaling system delay phosphate-driven organ damage?	8
A two-decade journey in identifying high mobility group box 1 (HMGB1) and procathepsin L (pCTS-L) as potential therapeutic targets for sepsis	8
An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection	8
TROP2 (trophoblast cell-surface antigen 2): a drug target for breast cancer	8
The molecular role of RE1 silencing transcription factor in uterine diseases: is there potential for targeted therapeutic development?	7
Modulating multidrug resistance to drug-based antitumor therapies through NF-κB signaling pathway: mechanisms and perspectives	7
Repurposing fluoxetine to treat lymphocytic leukemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction	7
Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors?	7
Assessing the current molecular understanding of therapeutic targets in osteosarcoma	7
Arenobufagin induces cell apoptosis by modulating the cell cycle regulator claspin and the JNK pathway in nasopharyngeal carcinoma cells	7
Targeting SHP2 phosphatase in hematological malignancies	6
NRG/ErbB signaling: on the trail of a molecular fingerprint in mucinous carcinoma	6
Sirtuins as therapeutic targets in diabetes	6
Glycometabolic rearrangements–aerobic glycolysis in pancreatic ductal adenocarcinoma (PDAC): roles, regulatory networks, and therapeutic potential	6
MT1-MMP – A potential drug target for the management of the obesity	6
Potential therapeutic targets and biomarkers in testicular germ cell tumor oncogenesis	6
Fatty acid-mediated signaling as a target for developing type 1 diabetes therapies	6
Tumor cells-derived extracellular vesicles carry circ_0064516 competitively inhibit microRNA-6805-3p and promote cervical cancer angiogenesis and tumor growth	6
Renal ciliopathies: promising drug targets and prospects for clinical trials	6
Unlocking the potential of melanotransferrin (CD228): implications for targeted drug development and novel therapeutic avenues	6
Therapeutic application of GLP-1 and GIP receptor agonists in Parkinson’s disease	6
Cytokines of the interleukin-6 family as emerging targets in inflammatory bowel disease	6
Novel and emerging targets for cholangiocarcinoma progression: therapeutic implications	6
Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy	6
TGF-β as a therapeutic target in the infarcted and failing heart: cellular mechanisms, challenges, and opportunities	6
Toxoplasma gondii infection: novel emerging therapeutic targets	6
Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?	6
Targeting mucosal healing in Crohn’s disease: efficacy of novel pathways and therapeutic targets	6
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases	6
Exploring PKG signaling as a therapeutic avenue for pressure overload, ischemia, and HFpEF	6
Enhancer of zeste homolog 2 (EZH2) in endocrine tumors: current knowledge and future directions	6
Focusing on oligomeric tau as a therapeutic target in Alzheimer’s disease and other tauopathies	6
Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets	6
Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging	6
Epigenetic regulation of immune cells in systemic lupus erythematosus: insight from chromatin accessibility	5
Novel chromobox 2 inhibitory peptide decreases tumor progression	5
Refining targeted therapeutic approaches in pancreatic cancer: from histology and molecular pathology to the clinic	5
Targeting GABA receptors with chalcone derivative compounds, what is the evidence?	5
Cataract-related mutations in EphA2: a survey of literature data and the relevance of the receptor Sam domain	5
The role of ubiquitination in microbial infection induced endothelial dysfunction: potential therapeutic targets for sepsis	5
Lipocalin-2 as a therapeutic target for diabetes neurological complications	5

miR-181a : regulatory roles, cancer-associated signaling pathway disruptions, and therapeutic potential	5
XBP1 as a novel molecular target to attenuate drug resistance in hepatocellular carcinoma	5
The molecular mechanisms and targeting strategies of transcription factors in cholangiocarcinoma	5
Type 1 diabetes: key drug targets and how they could influence future therapeutics	5
CDK6: an attractive therapeutic target for T-ALL/LBL	5
Epigenetic determinants in soft tissue sarcomas: molecular mechanisms and therapeutic targets	5
Potential of IDH mutations as immunotherapeutic targets in gliomas: a review and meta-analysis	5
Potential molecular targets for the pharmacologic management of non-traumatic osteonecrosis	5
Kv1.3 in the spotlight for treating immune diseases	5
Feasibility and considerations of epsin2 as a candidate target for multiple system atrophy treatment	5
Therapeutic perspectives on PDE4B inhibition in adipose tissue dysfunction and chronic liver injury	5
High levels of HDAC expression correlate with microglial aging	5
Therapeutic targets for pulmonary arterial hypertension: insights into the emerging landscape	5
SCN1A as a therapeutic target for Dravet syndrome	5
Airway smooth muscle in contractility and remodeling of asthma: potential drug target mechanisms	5
The participation of non-canonical autophagic proteins in the autophagy process and their potential as therapeutic targets	5
Advances in cerebellar disorders: pre-clinical models, therapeutic targets, and challenges	4
Guillain–Barré syndrome: immunopathogenesis and therapeutic targets	4
Glucocorticoid receptors participate in epilepsy in FCDII patients and MP model rats: A potential therapeutic target for epilepsy in patients with focal cortical dysplasia II (FCDII)	4
Candidate molecular targets uncovered in mouse lifespan extension studies	4
Uncovering immune pathways for therapeutic targeting of hypertension	4
miR-26a-5p restoration via EZH2 silencing blocks the IL-6/STAT3 axis to repress the growth of prostate cancer	4
The role of Nrf2 in immune cells and inflammatory autoimmune diseases: a comprehensive review	4
Multidimensional insights into squalene epoxidase drug development: in vitro mechanisms, in silico modeling, and in vivo	4
Emerging therapeutic targets for osteoarthritis	4
Galectin-3: therapeutic targeting in liver disease	4
PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date	4
OXPHOS-targeting drugs in oncology: new perspectives	4
The ATP-sensitive potassium channel: a therapeutic target for neurodegeneration?	4
TRPC3: how current mechanistic understanding provides a basis for therapeutic targeting	4
Targeting endoplasmic reticulum stress—the responder to lipotoxicity and modulator of non-alcoholic fatty liver diseases	4
Early clinical and pre-clinical therapy development in Nemaline myopathy	4
Therapeutic potential of RUNX1 and RUNX2 in bone metastasis of breast cancer	4
Duchenne cardiomyopathy: targeting ROS and NOX4 as a promising therapeutic strategy	4
Targeted therapeutic strategies for the kidney	4
Progress and challenges in glypican-3 targeting for hepatocellular carcinoma therapy	4
HIV Pol: does it offer therapeutic targets for HIV?	4
Correction	4
VPS35 or retromer as a potential target for neurodegenerative disorders: barriers to progress	4
Innovations in treating acute graft-versus-host disease: a review of preclinical targets and strategies	4
Targeting inflammasome complexes as a novel therapeutic strategy for mood disorders	4
Can we target insulin signalling for cognition therapeutics?	4