Expert Opinion on Therapeutic Targets

Article	Citations
Targeting transcription in neuroblastoma: focus on the core regulatory circuit	127
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy	60
IL-36: a therapeutic target for ulcerative colitis?	58
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines	48
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects	45
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA	42
Interleukin-18 in cancer immunology and immunotherapy	41
Mitochondrial permeability transition pore: a snapshot of a therapeutic target	37
CDK7 as a New therapeutic target in pancreatic and lung cancer: current evidence and future perspectives	37
Glycoproteins and longevity: an interview with Professor Gordan Lauc	36
Molecular basis for targeting TBK1 in CAR-T cell therapies for cancer	35
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement	34
Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing	34
The sigma–1 receptor: a mechanistically–informed therapeutic target for antidepressants	33
The membrane receptor CD44: roles in neurodegenerative diseases	32
MDA-9/Syntenin as a therapeutic cancer metastasis target: current molecular and preclinical understanding	32
The potential of multimolecular G-quadruplex structures for targeted treatment of Amyotrophic Lateral Sclerosis	29
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer	27
Current challenges in the discovery of treatments against Mayaro fever	26
Identification of target sites in the VHR (DUSP3) enzyme unlocking potential avenues for future sepsis treatment	24
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets	24
The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?	23
The challenges and potential of microRNA-based therapy for patients with liver failure syndromes and hepatocellular carcinoma	22
Novel signatures of prostate cancer progression and therapeutic resistance	22
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age	22

Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis	21
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath	21
Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy	20
KRAS mutations in colorectal cancer: impacts on tumor microenvironment and therapeutic implications	20
Antibacterial carbonic anhydrase inhibitors targeting Vibrio cholerae enzymes	20
Esophageal cancer: emerging therapeutics	19
Promising therapeutic targets for the treatment of urine storage dysfunction: what’s the status?	19
RBM47 as a therapeutic target in selected human diseases	19
The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin	19
The trap becomes the target: molecular basis for targeted inhibition of neutrophil extracellular traps in the pre-metastatic niche	19
Molecular pharmacology of multitarget cyclin-dependent kinase inhibitors in human colorectal carcinoma cells	19
Targeting PRL phosphatases in hematological malignancies	19
Progeria: a perspective on potential drug targets and treatment strategies	19
What do we know about the renin angiotensin system and inflammatory bowel disease?	18
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling	18
Targeting acid-sensing ion channels in glioblastoma: is there any therapeutic potential?	17
Sjögren’s syndrome: shedding light on emerging and key drug targets	17
Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABAB R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model	17
Tenosynovial giant cell tumors (TGCT): molecular biology, drug targets and non-surgical pharmacological approaches	17
Emerging therapeutic targets for anorexia nervosa	17
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications	16
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update	16
Atypical teratoid rhabdoid tumor (ATRT): disease mechanisms and potential drug targets	16
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?	16
Myocarditis: causes, mechanisms, and evolving therapies	16
ULK1 as a therapeutic target in kidney diseases: Current perspective	16
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?	16
Granzyme B as a therapeutic target: an update in 2022	16
GDF15: a potential therapeutic target for type 1 diabetes	16
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer	15
Mitochondria makeover: unlocking the path to healthy longevity	15
Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy	15
The contribution of fibronectin in epileptogenesis: therapeutic potential and mechanistic complexity	14
What is the potential of formyl peptide receptor 1 (FPR1) as a therapeutic target in human disease?	14
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers	14
XPO-1 targeting in chronic lymphocytic leukemia: is there potential for therapeutic strategy?	14
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets	13
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?	13
Rare tumors, real targets: patient-derived models for the discovery and validation of precision therapies	13
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression	13
Metabolic hallmarks of trastuzumab resistance	13
Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level	13
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies	13
Leveraging AI to identify dual-purpose aging and disease targets	13
Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness	13
Shedding light on emerging therapeutic targets for chordoma	12
Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies	12
Unveiling the role of mineralocorticoid receptor antagonists in epilepsy: the intersection of seizures, stress, and neuroinflammation	12
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	12
Cellular role of CD93 and its potential as a future therapeutic target	12

The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential	12
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders	12
An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models	11
FAM171A2 in Parkinson’s disease: mechanistic insights for a future therapeutic target	11
New therapeutic targets for endometrial cancer: a glimpse into the preclinical sphere	11
TAR DNA-binding protein of 43 kDa (TDP-43) and amyotrophic lateral sclerosis (ALS): a promising therapeutic target	11
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2	11
ORF6, a repressor of the MHC class I pathway: new molecular target for SARS-CoV-2 drug discovery?	11
The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies	11
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment	11
The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state	11
Considerations on the implementation of MAP4K4 inhibitors as cancer treatment	11
Emerging therapeutic targets for epilepsy: preclinical insights	11
The emerging role of TIM-3 in colorectal cancer: a promising target for immunotherapy	10
Targeting the Tumor-Tumor Microenvironment Crosstalk	10
Ways of modulating GABA transporters to treat neurological disease	10
Role of the P2Y12 receptor on thrombus formation and evolution in therapeutic strategies	10
Targeting the TRPV1 pain pathway in osteoarthritis of the knee	10
Potential therapeutic targets to prevent organ damage in chronic pulmonary sarcoidosis	10
Current strategies for targeting HPK1 in cancer and the barriers to preclinical progress	10
A two-decade journey in identifying high mobility group box 1 (HMGB1) and procathepsin L (pCTS-L) as potential therapeutic targets for sepsis	9
The potential for OGG1 inhibition to be a therapeutic strategy for pulmonary diseases	9
Emerging role for the Serum Response Factor (SRF) as a potential therapeutic target in cancer	9
The emerging role of Tetraspanin 32 in autoimmune diseases: from discovery to relevant theranostics?	9
Restoring FXR expression as a novel treatment strategy in liver cancer and other liver disorders	9
Emerging drug targets for triple-negative breast cancer: a guided tour of the preclinical landscape	9
Emerging pathways yielding opportunities for future treatments in pancreatic ductal adenocarcinoma	9
aMMP-8 point-of-care - diagnostic methods and treatment modalities in periodontitis and peri-implantitis	9
An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection	9
Cardiac conduction diseases: understanding the molecular mechanisms to uncover targets for future treatments	9
The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review	8
Can targeting the FGF23-αKlotho signaling system delay phosphate-driven organ damage?	8
Renal fibrosis as a hallmark of diabetic kidney disease: potential role of targeting transforming growth factor-beta (TGF-β) and related molecules	8
Acute myeloid leukemia: therapeutic targeting of stem cells	8
Gateway reflexes are neural circuits that establish the gateway of immune cells to regulate tissue specific inflammation	8
Pharmacological targeting of ECM homeostasis, fibroblast activation and invasion for the treatment of pulmonary fibrosis	8
TROP2 (trophoblast cell-surface antigen 2): a drug target for breast cancer	8
Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors?	7
Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?	7
Renal ciliopathies: promising drug targets and prospects for clinical trials	7
Modulating multidrug resistance to drug-based antitumor therapies through NF-κB signaling pathway: mechanisms and perspectives	7
Arenobufagin induces cell apoptosis by modulating the cell cycle regulator claspin and the JNK pathway in nasopharyngeal carcinoma cells	7
NRG/ErbB signaling: on the trail of a molecular fingerprint in mucinous carcinoma	7
Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets	7
Fatty liver disease: time to target CCR5?	7
The molecular role of RE1 silencing transcription factor in uterine diseases: is there potential for targeted therapeutic development?	7
Toxoplasma gondii infection: novel emerging therapeutic targets	7
Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging	7
CDK6: an attractive therapeutic target for T-ALL/LBL	6
The molecular mechanisms and targeting strategies of transcription factors in cholangiocarcinoma	6
GADD45: a crucial component of the DNA damage response and a potential cancer therapeutic target	6
Therapeutic application of GLP-1 and GIP receptor agonists in Parkinson’s disease	6
Sirtuins as therapeutic targets in diabetes	6
TGF-β as a therapeutic target in the infarcted and failing heart: cellular mechanisms, challenges, and opportunities	6
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases	6
Tumor cells-derived extracellular vesicles carry circ_0064516 competitively inhibit microRNA-6805-3p and promote cervical cancer angiogenesis and tumor growth	6
Repurposing fluoxetine to treat lymphocytic leukemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction	6
Novel chromobox 2 inhibitory peptide decreases tumor progression	6
Feasibility and considerations of epsin2 as a candidate target for multiple system atrophy treatment	6
Enhancer of zeste homolog 2 (EZH2) in endocrine tumors: current knowledge and future directions	6
Cytokines of the interleukin-6 family as emerging targets in inflammatory bowel disease	6
Focusing on oligomeric tau as a therapeutic target in Alzheimer’s disease and other tauopathies	6
MT1-MMP – A potential drug target for the management of the obesity	6
Targeting mucosal healing in Crohn’s disease: efficacy of novel pathways and therapeutic targets	6
Fatty acid-mediated signaling as a target for developing type 1 diabetes therapies	6
Assessing the current molecular understanding of therapeutic targets in osteosarcoma	6
XBP1 as a novel molecular target to attenuate drug resistance in hepatocellular carcinoma	6
miR-181a : regulatory roles, cancer-associated signaling pathway disruptions, and therapeutic potential	6
Kv1.3 in the spotlight for treating immune diseases	6
Autophagic failure with age: influence on metabolic disorders and prospects for therapeutic targeting	6
Exploring PKG signaling as a therapeutic avenue for pressure overload, ischemia, and HFpEF	6
Potential therapeutic targets and biomarkers in testicular germ cell tumor oncogenesis	6
Unlocking the potential of melanotransferrin (CD228): implications for targeted drug development and novel therapeutic avenues	6
Novel and emerging targets for cholangiocarcinoma progression: therapeutic implications	6
Targeting SHP2 phosphatase in hematological malignancies	6
Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy	6
Epigenetic regulation of immune cells in systemic lupus erythematosus: insight from chromatin accessibility	6
Correction	5
Progress and challenges in glypican-3 targeting for hepatocellular carcinoma therapy	5
Targeted therapeutic strategies for the kidney	5

HIV Pol: does it offer therapeutic targets for HIV?	5
Uncovering immune pathways for therapeutic targeting of hypertension	5
Airway smooth muscle in contractility and remodeling of asthma: potential drug target mechanisms	5
Sugars to signals: emerging roles of PAK1 in re-wiring glucose metabolism in cancers	5
Type 1 diabetes: key drug targets and how they could influence future therapeutics	5
Paraspeckle component 1 in acute myeloid leukemia: prospects for therapeutic targeting	5
SCN1A as a therapeutic target for Dravet syndrome	5
Candidate molecular targets uncovered in mouse lifespan extension studies	5
The ATP-sensitive potassium channel: a therapeutic target for neurodegeneration?	5
Advances in cerebellar disorders: pre-clinical models, therapeutic targets, and challenges	5
Potential molecular targets for the pharmacologic management of non-traumatic osteonecrosis	5
Epigenetic determinants in soft tissue sarcomas: molecular mechanisms and therapeutic targets	5
High levels of HDAC expression correlate with microglial aging	5
Targeting GABA receptors with chalcone derivative compounds, what is the evidence?	5
Lipocalin-2 as a therapeutic target for diabetes neurological complications	5
Glucocorticoid receptors participate in epilepsy in FCDII patients and MP model rats: A potential therapeutic target for epilepsy in patients with focal cortical dysplasia II (FCDII)	5
Cataract-related mutations in EphA2: a survey of literature data and the relevance of the receptor Sam domain	5
Galectin-3: therapeutic targeting in liver disease	5
The participation of non-canonical autophagic proteins in the autophagy process and their potential as therapeutic targets	5
Targeting endoplasmic reticulum stress—the responder to lipotoxicity and modulator of non-alcoholic fatty liver diseases	5
The role of ubiquitination in microbial infection induced endothelial dysfunction: potential therapeutic targets for sepsis	5
Therapeutic perspectives on PDE4B inhibition in adipose tissue dysfunction and chronic liver injury	5
Therapeutic targets for pulmonary arterial hypertension: insights into the emerging landscape	5