Expert Opinion on Therapeutic Targets

Article	Citations
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy	114
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA	57
IL-36: a therapeutic target for ulcerative colitis?	52
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines	48
Interleukin-18 in cancer immunology and immunotherapy	43
Targeting transcription in neuroblastoma: focus on the core regulatory circuit	38
Mitochondrial permeability transition pore: a snapshot of a therapeutic target	38
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects	36
The sigma–1 receptor: a mechanistically–informed therapeutic target for antidepressants	33
Molecular basis for targeting TBK1 in CAR-T cell therapies for cancer	32
Glycoproteins and longevity: an interview with Professor Gordan Lauc	32
Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications	31
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement	30
Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing	30
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer	28
NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): seven years between lights and shadows	28
Current challenges in the discovery of treatments against Mayaro fever	26
A short report on NGM282/aldafermin for the treatment of nonalcoholic steatohepatitis (NASH)	26
MDA-9/Syntenin as a therapeutic cancer metastasis target: current molecular and preclinical understanding	26
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study	25
The potential of multimolecular G-quadruplex structures for targeted treatment of Amyotrophic Lateral Sclerosis	25
Clostridioides difficile: innovations in target discovery and potential for therapeutic success	24
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets	24
Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy	24
Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis	23

KRAS mutations in colorectal cancer: impacts on tumor microenvironment and therapeutic implications	22
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath	22
The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?	21
Antibacterial carbonic anhydrase inhibitors targeting Vibrio cholerae enzymes	21
Uncovering key targets of success for immunotherapy in pancreatic cancer	20
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age	20
The challenges and potential of microRNA-based therapy for patients with liver failure syndromes and hepatocellular carcinoma	19
Esophageal cancer: emerging therapeutics	19
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)	18
Novel signatures of prostate cancer progression and therapeutic resistance	18
Progeria: a perspective on potential drug targets and treatment strategies	17
Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABAB R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model	17
Tenosynovial giant cell tumors (TGCT): molecular biology, drug targets and non-surgical pharmacological approaches	17
Targeting PRL phosphatases in hematological malignancies	16
The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin	16
RBM47 as a therapeutic target in selected human diseases	16
The trap becomes the target: molecular basis for targeted inhibition of neutrophil extracellular traps in the pre-metastatic niche	16
What do we know about the renin angiotensin system and inflammatory bowel disease?	16
Molecular pharmacology of multitarget cyclin-dependent kinase inhibitors in human colorectal carcinoma cells	16
Targeting acid-sensing ion channels in glioblastoma: is there any therapeutic potential?	16
Promising therapeutic targets for the treatment of urine storage dysfunction: what’s the status?	16
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling	16
ULK1 as a therapeutic target in kidney diseases: Current perspective	16
Emerging therapeutic targets for anorexia nervosa	15
Sjögren’s syndrome: shedding light on emerging and key drug targets	15
Atypical teratoid rhabdoid tumor (ATRT): disease mechanisms and potential drug targets	15
GDF15: a potential therapeutic target for type 1 diabetes	15
Myocarditis: causes, mechanisms, and evolving therapies	14
What is the potential of formyl peptide receptor 1 (FPR1) as a therapeutic target in human disease?	14
Granzyme B as a therapeutic target: an update in 2022	14
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update	14
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?	14
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies	13
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer	13
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications	13
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets	13
Retinal vein occlusion: drug targets and therapeutic implications	13
Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy	13
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?	13
Mitochondria makeover: unlocking the path to healthy longevity	13
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers	12
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?	12
Metabolic hallmarks of trastuzumab resistance	12
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders	12
The mechanisms and therapeutic targets of ferroptosis in cancer	12
Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies	12
Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness	12
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	12
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression	12
Leveraging AI to identify dual-purpose aging and disease targets	12

Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level	12
Epigenetic regulatory mechanisms of histone acetylation in the treatment of cutaneous squamous cell carcinoma	12
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential	11
An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models	11
Rare tumors, real targets: patient-derived models for the discovery and validation of precision therapies	11
Influence of the inflammasome complex on psychiatric disorders: clinical and preclinical studies	11
The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies	11
Cellular role of CD93 and its potential as a future therapeutic target	11
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2	10
Ways of modulating GABA transporters to treat neurological disease	10
Emerging therapeutic targets for epilepsy: preclinical insights	10
New therapeutic targets for endometrial cancer: a glimpse into the preclinical sphere	10
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment	10
Considerations on the implementation of MAP4K4 inhibitors as cancer treatment	10
The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state	10
ORF6, a repressor of the MHC class I pathway: new molecular target for SARS-CoV-2 drug discovery?	10
Shedding light on emerging therapeutic targets for chordoma	10
TAR DNA-binding protein of 43 kDa (TDP-43) and amyotrophic lateral sclerosis (ALS): a promising therapeutic target	10
Current strategies for targeting HPK1 in cancer and the barriers to preclinical progress	10
Targeting the Tumor-Tumor Microenvironment Crosstalk	9
Role of the P2Y12 receptor on thrombus formation and evolution in therapeutic strategies	9
Emerging drug targets for triple-negative breast cancer: a guided tour of the preclinical landscape	9
The emerging role of Tetraspanin 32 in autoimmune diseases: from discovery to relevant theranostics?	9
The potential for OGG1 inhibition to be a therapeutic strategy for pulmonary diseases	9
Targeting the TRPV1 pain pathway in osteoarthritis of the knee	9
Potential therapeutic targets to prevent organ damage in chronic pulmonary sarcoidosis	9
The emerging role of TIM-3 in colorectal cancer: a promising target for immunotherapy	9
Cardiac conduction diseases: understanding the molecular mechanisms to uncover targets for future treatments	9
Emerging pathways yielding opportunities for future treatments in pancreatic ductal adenocarcinoma	9
Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles	9
TROP2 (trophoblast cell-surface antigen 2): a drug target for breast cancer	9
A two-decade journey in identifying high mobility group box 1 (HMGB1) and procathepsin L (pCTS-L) as potential therapeutic targets for sepsis	9
Restoring FXR expression as a novel treatment strategy in liver cancer and other liver disorders	9
aMMP-8 point-of-care - diagnostic methods and treatment modalities in periodontitis and peri-implantitis	8
Gateway reflexes are neural circuits that establish the gateway of immune cells to regulate tissue specific inflammation	8
An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection	8
Pharmacological targeting of ECM homeostasis, fibroblast activation and invasion for the treatment of pulmonary fibrosis	8
Renal fibrosis as a hallmark of diabetic kidney disease: potential role of targeting transforming growth factor-beta (TGF-β) and related molecules	8
Emerging role for the Serum Response Factor (SRF) as a potential therapeutic target in cancer	8
NRG/ErbB signaling: on the trail of a molecular fingerprint in mucinous carcinoma	7
Acute myeloid leukemia: therapeutic targeting of stem cells	7
Fatty liver disease: time to target CCR5?	7
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases	7
Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?	7
Targeting mucosal healing in Crohn’s disease: efficacy of novel pathways and therapeutic targets	7
The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review	7
Can targeting the FGF23-αKlotho signaling system delay phosphate-driven organ damage?	7
Assessing the current molecular understanding of therapeutic targets in osteosarcoma	7
Toxoplasma gondii infection: novel emerging therapeutic targets	7
Targeting SHP2 phosphatase in hematological malignancies	7
Endothelial dysfunction: a therapeutic target in bacterial sepsis?	7
Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors?	7
Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging	7
Fatty acid-mediated signaling as a target for developing type 1 diabetes therapies	6
Renal ciliopathies: promising drug targets and prospects for clinical trials	6
Arenobufagin induces cell apoptosis by modulating the cell cycle regulator claspin and the JNK pathway in nasopharyngeal carcinoma cells	6
Epigenetic regulation of immune cells in systemic lupus erythematosus: insight from chromatin accessibility	6
Enhancer of zeste homolog 2 (EZH2) in endocrine tumors: current knowledge and future directions	6
Sirtuins as therapeutic targets in diabetes	6
Tumor cells-derived extracellular vesicles carry circ_0064516 competitively inhibit microRNA-6805-3p and promote cervical cancer angiogenesis and tumor growth	6
Modulating multidrug resistance to drug-based antitumor therapies through NF-κB signaling pathway: mechanisms and perspectives	6
XBP1 as a novel molecular target to attenuate drug resistance in hepatocellular carcinoma	6
MT1-MMP – A potential drug target for the management of the obesity	6
Kv1.3 in the spotlight for treating immune diseases	6
Unlocking the potential of melanotransferrin (CD228): implications for targeted drug development and novel therapeutic avenues	6
TGF-β as a therapeutic target in the infarcted and failing heart: cellular mechanisms, challenges, and opportunities	6
Repurposing fluoxetine to treat lymphocytic leukemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction	6
Cholangiocarcinoma: what are the most valuable therapeutic targets – cancer-associated fibroblasts, immune cells, or beyond T cells?	6
Potential therapeutic targets and biomarkers in testicular germ cell tumor oncogenesis	6
Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets	6
Exploring PKG signaling as a therapeutic avenue for pressure overload, ischemia, and HFpEF	6
High levels of HDAC expression correlate with microglial aging	5
Small molecule neurolysin activators, potential multi-mechanism agents for ischemic stroke therapy	5
Glycometabolic rearrangements–aerobic glycolysis in pancreatic ductal adenocarcinoma (PDAC): roles, regulatory networks, and therapeutic potential	5
Targeting GABA receptors with chalcone derivative compounds, what is the evidence?	5
Novel chromobox 2 inhibitory peptide decreases tumor progression	5
Therapeutic perspectives on PDE4B inhibition in adipose tissue dysfunction and chronic liver injury	5
The role of ubiquitination in microbial infection induced endothelial dysfunction: potential therapeutic targets for sepsis	5
CDK6: an attractive therapeutic target for T-ALL/LBL	5
Cytokines of the interleukin-6 family as emerging targets in inflammatory bowel disease	5

Novel and emerging targets for cholangiocarcinoma progression: therapeutic implications	5
Refining targeted therapeutic approaches in pancreatic cancer: from histology and molecular pathology to the clinic	5
The molecular mechanisms and targeting strategies of transcription factors in cholangiocarcinoma	5
miR-181a : regulatory roles, cancer-associated signaling pathway disruptions, and therapeutic potential	5
Epigenetic determinants in soft tissue sarcomas: molecular mechanisms and therapeutic targets	5
Potential of IDH mutations as immunotherapeutic targets in gliomas: a review and meta-analysis	5
Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) – the involvement of mitochondrial quality control, autophagy, and antioxidant response	5
Focusing on oligomeric tau as a therapeutic target in Alzheimer’s disease and other tauopathies	5
Therapeutic application of GLP-1 and GIP receptor agonists in Parkinson’s disease	5
Feasibility and considerations of epsin2 as a candidate target for multiple system atrophy treatment	5
Type 1 diabetes: key drug targets and how they could influence future therapeutics	5
Cataract-related mutations in EphA2: a survey of literature data and the relevance of the receptor Sam domain	5
Airway smooth muscle in contractility and remodeling of asthma: potential drug target mechanisms	5
SCN1A as a therapeutic target for Dravet syndrome	4
TRPC3: how current mechanistic understanding provides a basis for therapeutic targeting	4
Candidate molecular targets uncovered in mouse lifespan extension studies	4
Correction	4
The ATP-sensitive potassium channel: a therapeutic target for neurodegeneration?	4
Advances in cerebellar disorders: pre-clinical models, therapeutic targets, and challenges	4
HIV Pol: does it offer therapeutic targets for HIV?	4
Lipocalin-2 as a therapeutic target for diabetes neurological complications	4
Galectin-3: therapeutic targeting in liver disease	4
Potential molecular targets for the pharmacologic management of non-traumatic osteonecrosis	4
Progress and challenges in glypican-3 targeting for hepatocellular carcinoma therapy	4
Targeting endoplasmic reticulum stress—the responder to lipotoxicity and modulator of non-alcoholic fatty liver diseases	4
Therapeutic targets for pulmonary arterial hypertension: insights into the emerging landscape	4
Emerging therapeutic targets for osteoarthritis	4
The participation of non-canonical autophagic proteins in the autophagy process and their potential as therapeutic targets	4
OXPHOS-targeting drugs in oncology: new perspectives	4
Uncovering immune pathways for therapeutic targeting of hypertension	4
Glucocorticoid receptors participate in epilepsy in FCDII patients and MP model rats: A potential therapeutic target for epilepsy in patients with focal cortical dysplasia II (FCDII)	4
Targeted therapeutic strategies for the kidney	4