OOIR: Observatory of International Research

Papers

(The TQCC of Expert Opinion on Therapeutic Targets is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy	114
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA	57
IL-36: a therapeutic target for ulcerative colitis?	52
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines	48
Interleukin-18 in cancer immunology and immunotherapy	43
Targeting transcription in neuroblastoma: focus on the core regulatory circuit	38
Mitochondrial permeability transition pore: a snapshot of a therapeutic target	38
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects	36
The sigma–1 receptor: a mechanistically–informed therapeutic target for antidepressants	33
Molecular basis for targeting TBK1 in CAR-T cell therapies for cancer	32
Glycoproteins and longevity: an interview with Professor Gordan Lauc	32
Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications	31
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement	30
Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing	30
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer	28
NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): seven years between lights and shadows	28
Current challenges in the discovery of treatments against Mayaro fever	26
A short report on NGM282/aldafermin for the treatment of nonalcoholic steatohepatitis (NASH)	26
MDA-9/Syntenin as a therapeutic cancer metastasis target: current molecular and preclinical understanding	26
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study	25
The potential of multimolecular G-quadruplex structures for targeted treatment of Amyotrophic Lateral Sclerosis	25
Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy	24
Clostridioides difficile: innovations in target discovery and potential for therapeutic success	24
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets	24
Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis	23

KRAS mutations in colorectal cancer: impacts on tumor microenvironment and therapeutic implications	22
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath	22
Antibacterial carbonic anhydrase inhibitors targeting Vibrio cholerae enzymes	21
The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?	21
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age	20
Uncovering key targets of success for immunotherapy in pancreatic cancer	20
The challenges and potential of microRNA-based therapy for patients with liver failure syndromes and hepatocellular carcinoma	19
Esophageal cancer: emerging therapeutics	19
Novel signatures of prostate cancer progression and therapeutic resistance	18
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)	18
Tenosynovial giant cell tumors (TGCT): molecular biology, drug targets and non-surgical pharmacological approaches	17
Progeria: a perspective on potential drug targets and treatment strategies	17
Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABA_B R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model	17
Targeting PRL phosphatases in hematological malignancies	16
The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin	16
RBM47 as a therapeutic target in selected human diseases	16
The trap becomes the target: molecular basis for targeted inhibition of neutrophil extracellular traps in the pre-metastatic niche	16
What do we know about the renin angiotensin system and inflammatory bowel disease?	16
Molecular pharmacology of multitarget cyclin-dependent kinase inhibitors in human colorectal carcinoma cells	16
Targeting acid-sensing ion channels in glioblastoma: is there any therapeutic potential?	16
Promising therapeutic targets for the treatment of urine storage dysfunction: what’s the status?	16
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling	16
ULK1 as a therapeutic target in kidney diseases: Current perspective	16
Emerging therapeutic targets for anorexia nervosa	15
Sjögren’s syndrome: shedding light on emerging and key drug targets	15
Atypical teratoid rhabdoid tumor (ATRT): disease mechanisms and potential drug targets	15
GDF15: a potential therapeutic target for type 1 diabetes	15
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update	14
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?	14
Myocarditis: causes, mechanisms, and evolving therapies	14
What is the potential of formyl peptide receptor 1 (FPR1) as a therapeutic target in human disease?	14
Granzyme B as a therapeutic target: an update in 2022	14
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?	13
Mitochondria makeover: unlocking the path to healthy longevity	13
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies	13
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer	13
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications	13
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets	13
Retinal vein occlusion: drug targets and therapeutic implications	13
Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy	13
Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level	12
Epigenetic regulatory mechanisms of histone acetylation in the treatment of cutaneous squamous cell carcinoma	12
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers	12
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?	12
Metabolic hallmarks of trastuzumab resistance	12
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders	12
The mechanisms and therapeutic targets of ferroptosis in cancer	12
Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies	12
Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness	12
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses	12

The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression	12
Leveraging AI to identify dual-purpose aging and disease targets	12
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential	11
An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models	11
Rare tumors, real targets: patient-derived models for the discovery and validation of precision therapies	11
Influence of the inflammasome complex on psychiatric disorders: clinical and preclinical studies	11
The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies	11
Cellular role of CD93 and its potential as a future therapeutic target	11
Shedding light on emerging therapeutic targets for chordoma	10
Current strategies for targeting HPK1 in cancer and the barriers to preclinical progress	10
TAR DNA-binding protein of 43 kDa (TDP-43) and amyotrophic lateral sclerosis (ALS): a promising therapeutic target	10
Ways of modulating GABA transporters to treat neurological disease	10
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-2	10
New therapeutic targets for endometrial cancer: a glimpse into the preclinical sphere	10
Emerging therapeutic targets for epilepsy: preclinical insights	10
Considerations on the implementation of MAP4K4 inhibitors as cancer treatment	10
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment	10
ORF6, a repressor of the MHC class I pathway: new molecular target for SARS-CoV-2 drug discovery?	10
The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state	10