Expert Opinion on Therapeutic Targets

Papers
(The TQCC of Expert Opinion on Therapeutic Targets is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
Assessing platelet-derived extracellular vesicles for potential as therapeutic targets in cardiovascular diseases102
Endothelial dysfunction: a therapeutic target in bacterial sepsis?56
Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy46
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?43
Targeting ALK receptors in non-small cell lung cancer: what is the road ahead?41
HIV Pol: does it offer therapeutic targets for HIV?35
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer35
Fatty liver disease: time to target CCR5?33
Ubiquitin-specific protease 7 (USP7): an emerging drug target for cancer treatment33
Retinal vein occlusion: drug targets and therapeutic implications33
Novel therapeutic targets for diabetes-related wounds or ulcers: an update on preclinical and clinical research31
Emerging therapeutic targets for narcolepsy30
Targeting VCAM-1: a therapeutic opportunity for vascular damage29
Dyskinesia and Parkinson’s disease: animal model, drug targets, and agents in preclinical testing28
IL-36: a therapeutic target for ulcerative colitis?28
An update on novel pharmacological agents for primary sclerosing cholangitis27
Glucocorticoid receptors participate in epilepsy in FCDII patients and MP model rats: A potential therapeutic target for epilepsy in patients with focal cortical dysplasia II (FCDII)27
The ATP-sensitive potassium channel: a therapeutic target for neurodegeneration?24
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA24
Glucose-6-phosphate dehydrogenase: a therapeutic target for ovarian cancer24
lncRNAs: potential therapeutic targets and biomarkers for pancreatic cancer?24
Advances in cerebellar disorders: pre-clinical models, therapeutic targets, and challenges24
Tolperisone induces UPR-mediated tumor inhibition and synergizes with proteasome inhibitor and immunotherapy by targeting LSD124
Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential24
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy23
Mitochondria makeover: unlocking the path to healthy longevity23
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications22
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?21
Understanding the role of galectins toward influenza A virus infection21
Targeting the CTLA-4/B7 axes in glioblastoma: preclinical evidence and clinical interventions21
Druggable genes for therapeutic targeting in PTH signaling for osteoporosis21
Powering down the mitochondrial LonP1 protease: a novel strategy for anticancer therapeutics21
Targeted therapeutic strategies for the kidney21
Gateway reflexes are neural circuits that establish the gateway of immune cells to regulate tissue specific inflammation21
Correction20
OXPHOS-targeting drugs in oncology: new perspectives20
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines20
Mitochondrial permeability transition pore: a snapshot of a therapeutic target20
Interleukin-18 in cancer immunology and immunotherapy19
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects18
Human prion disease: molecular pathogenesis, and possible therapeutic targets and strategies18
The role of the ATP-Binding Cassette A1 (ABCA1) in neurological disorders: a mechanistic review18
Can targeting the FGF23-αKlotho signaling system delay phosphate-driven organ damage?18
An overview of novel antimicrobial carbonic anhydrase inhibitors17
MET alterations and their impact on the future of non-small cell lung cancer (NSCLC) targeted therapies17
Pharmacological targeting of ECM homeostasis, fibroblast activation and invasion for the treatment of pulmonary fibrosis17
Acute myeloid leukemia: therapeutic targeting of stem cells16
Galectin-3: therapeutic targeting in liver disease15
TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-215
Glycoproteins and longevity: an interview with Professor Gordan Lauc15
Progress and challenges in glypican-3 targeting for hepatocellular carcinoma therapy15
miR-26a-5p restoration via EZH2 silencing blocks the IL-6/STAT3 axis to repress the growth of prostate cancer14
Mast cell chymase-1 and tryptases: therapeutic targets for COPD?14
Navigating the landscape of psoriasis therapy: novel targeted pathways and emerging trends14
NF-κB-inducing kinase (NIK): an emerging therapeutic target in human disease14
Aberrations of DNA repair pathways in prostate cancer: a cornerstone of precision oncology14
Can we suppress chronic systemic inflammation and postpone age-related diseases by targeting the IgG glycome?14
Tumor cells-derived extracellular vesicles carry circ_0064516 competitively inhibit microRNA-6805-3p and promote cervical cancer angiogenesis and tumor growth13
Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway12
Combining rejuvenation interventions in rodents: a milestone in biomedical gerontology whose time has come12
Targeting mucosal healing in Crohn’s disease: efficacy of novel pathways and therapeutic targets11
The mineralocorticoid receptor signal could be a new molecular target for the treatment of diabetic retinal complication11
Preclinical target validation for non-addictive therapeutics development for pain11
TRPC3: how current mechanistic understanding provides a basis for therapeutic targeting11
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases11
Axial spondyloarthritis: emerging drug targets11
Chemokine signaling in tumors: potential role of CXC chemokines and their receptors as glioblastoma therapeutic targets11
Repurposing fluoxetine to treat lymphocytic leukemia: Apoptosis induction, sigma-1 receptor upregulation, inhibition of IL-2 cytokine production, and autophagy induction11
Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging11
Casein Kinase II exacerbates rheumatoid arthritis via promoting Th1 and Th17 cell inflammatory responses10
Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications10
Emerging therapeutic targets for osteoarthritis10
Triple-negative breast cancer drug resistance, durable efficacy, and cure: how advanced biological insights and emerging drug modalities could transform progress9
Fatty acid-mediated signaling as a target for developing type 1 diabetes therapies9
Unraveling therapeutic targets in acute myeloid leukemia through multiplexed genome editing CRISPR screening9
Major depressive disorder (mdd): emerging immune targets at preclinical level9
Leucine-rich repeat kinase 2 (LRRK2): an update on the potential therapeutic target for Parkinson’s disease9
Lipid metabolism in malignant tumor brain metastasis: reprogramming and therapeutic potential9
Modulating multidrug resistance to drug-based antitumor therapies through NF-κB signaling pathway: mechanisms and perspectives9
Guillain–Barré syndrome: immunopathogenesis and therapeutic targets9
TGF-β as a therapeutic target in the infarcted and failing heart: cellular mechanisms, challenges, and opportunities9
The role of the sigma-1 receptor in neuroprotection: Comment on Nrf-2 as a therapeutic target in ischemic stroke9
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement9
Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?9
Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets9
The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting9
Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing9
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets9
Microglia as therapeutic targets after neurological injury: strategy for cell therapy8
Arenobufagin induces cell apoptosis by modulating the cell cycle regulator claspin and the JNK pathway in nasopharyngeal carcinoma cells8
Hypoplastic left heart syndrome (HLHS): molecular pathogenesis and emerging drug targets for cardiac repair and regeneration8
Renal ciliopathies: promising drug targets and prospects for clinical trials8
NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): seven years between lights and shadows8
Toxoplasma gondii infection: novel emerging therapeutic targets8
PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date8
Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder8
Targeting inflammasome complexes as a novel therapeutic strategy for mood disorders8
The role of immune response in the pathogenesis of idiopathic pulmonary fibrosis: far beyond the Th1/Th2 imbalance8
Synaptic fidelity for drug development: is it time to move beyond glutamate release and receptors?8
The mechanisms and therapeutic targets of ferroptosis in cancer8
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression8
Targeting the EGFR signaling pathway in cancer therapy: What’s new in 2023?8
VPS35 or retromer as a potential target for neurodegenerative disorders: barriers to progress8
Cholangiocarcinoma: what are the most valuable therapeutic targets – cancer-associated fibroblasts, immune cells, or beyond T cells?8
Hepatitis B virus: promising drug targets and therapeutic implications8
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies8
Targeting SHP2 phosphatase in hematological malignancies8
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers8
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