Expert Opinion on Therapeutic Targets

Papers
(The TQCC of Expert Opinion on Therapeutic Targets is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
ArticleCitations
Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma115
TRPA1 as a therapeutic target for nociceptive pain97
The cytokine storm of COVID-19: a spotlight on prevention and protection77
Esophageal cancer: emerging therapeutics52
Therapeutic antibodies and fusion inhibitors targeting the spike protein of SARS-CoV-249
New therapeutic targets in chronic kidney disease progression and renal fibrosis41
Aberrations of DNA repair pathways in prostate cancer: a cornerstone of precision oncology40
Glioblastoma multiforme: novel therapeutic targets38
Omentin-1: a newly discovered warrior against metabolic related diseases36
Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease36
Nutritional intervention in chronic pain: an innovative way of targeting central nervous system sensitization?35
The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma33
TLR4 as a therapeutic target for respiratory and neurological complications of SARS-CoV-233
CCR5 is a potential therapeutic target for cancer32
HSP47: a potential target for fibrotic diseases and implications for therapy30
Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain28
Targeting TANK-binding kinase 1 (TBK1) in cancer27
The role of microRNA in cisplatin resistance or sensitivity27
Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy26
Is neurotrophin-3 (NT-3): a potential therapeutic target for depression and anxiety?24
Reversing T-cell exhaustion in immunotherapy: a review on current approaches and limitations24
MET alterations and their impact on the future of non-small cell lung cancer (NSCLC) targeted therapies23
Systemic lupus erythematosus (SLE): emerging therapeutic targets23
Microglia as therapeutic targets after neurological injury: strategy for cell therapy23
PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date22
The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer’s22
Tumor-associated neutrophils: orchestrating cancer pathobiology and therapeutic resistance21
The gut microbiome as a target for adjuvant therapy in obstructive sleep apnea21
The mechanisms and therapeutic targets of ferroptosis in cancer21
Liver X receptor: a potential target in the treatment of atherosclerosis21
The emerging role of the Angiopoietin-Tie pathway as therapeutic target for treating retinal diseases21
Activin A: an emerging target for improving cancer treatment?20
Targeting p53 in chronic lymphocytic leukemia20
Myeloperoxidase: a potential therapeutic target for coronary artery disease20
Calpain as a therapeutic target in cancer20
CD36 as a target for metabolic modulation therapy in cardiac disease18
Therapeutic application of GLP-1 and GIP receptor agonists in Parkinson’s disease18
Redox-sensitive TRP channels: a promising pharmacological target in chemotherapy-induced peripheral neuropathy17
Targeting translesion synthesis (TLS) to expose replication gaps, a unique cancer vulnerability17
TAM kinase inhibition and immune checkpoint blockade– a winning combination in cancer treatment?17
Nrf2 as a therapeutic target in ischemic stroke17
The BAFF / APRIL system as therapeutic target in multiple sclerosis17
Targeting Fc effector function in vaccine design17
Autoimmune encephalitis: novel therapeutic targets at the preclinical level17
Targeting RUNX1 in acute myeloid leukemia: preclinical innovations and therapeutic implications16
The interaction between microbiome and host central nervous system: the gut-brain axis as a potential new therapeutic target in the treatment of obesity and cardiometabolic disease16
Targeting TIM-3 in solid tumors: innovations in the preclinical and translational realm and therapeutic potential16
Emerging therapeutic targets for cerebral edema15
Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity15
RNA in spinal muscular atrophy: therapeutic implications of targeting15
Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases15
Epigenetic regulation in Alzheimer’s disease: is it a potential therapeutic target?14
Emerging therapeutic targets for schizophrenia: a framework for novel treatment strategies for psychosis14
Transglutaminase 2 as a therapeutic target for neurological conditions14
Potassium channels as prominent targets and tools for the treatment of epilepsy14
Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway14
Emerging therapeutic targets for neuroblastoma14
Emerging therapeutic targets for cardiac hypertrophy14
The potential for immune checkpoint modulators in cerebrovascular injury and inflammation14
Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles13
Emerging therapeutic targets for gastric cancer from a host-Helicobacter pylori interaction perspective13
Non-histone substrates of histone deacetylases as potential therapeutic targets in epilepsy13
The necroptosis pathway and its role in age-related neurodegenerative diseases: will it open up new therapeutic avenues in the next decade?13
Endothelial dysfunction: a therapeutic target in bacterial sepsis?13
GDF15: a potential therapeutic target for type 1 diabetes12
Emerging therapeutic targets for sepsis12
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study12
Novel immune targets for the treatment of triple-negative breast cancer12
Fumarate hydratase as a therapeutic target in renal cancer12
Renal fibrosis as a hallmark of diabetic kidney disease: potential role of targeting transforming growth factor-beta (TGF-β) and related molecules12
Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) – the involvement of mitochondrial quality control, autophagy, and antioxidant response12
Salivary gland cancer in the era of immunotherapy: can we exploit tumor microenvironment?12
Glutamatergic dysregulation in mood disorders: opportunities for the discovery of novel drug targets11
The ceramide-S1P pathway as a druggable target to alleviate peripheral neuropathic pain11
The gut-brain axis and gut inflammation in Parkinson’s disease: stopping neurodegeneration at the toll gate11
Deciphering Alzheimer’s disease: predicting new therapeutic strategies via improved understanding of biology and pathogenesis11
Novel drug targets for treatment of cryptosporidiosis11
The CB2 cannabinoid receptor as a therapeutic target in the central nervous system11
Therapeutic targets for enterovirus infections11
Targeting the tumor microenvironment in cholangiocarcinoma: implications for therapy10
Emerging therapeutic targets for osteoarthritis10
A vasculature-centric approach to developing novel treatment options for glioblastoma10
Fatty acid synthase: a druggable driver of breast cancer brain metastasis10
Emerging therapeutic targets for nasopharyngeal carcinoma: opportunities and challenges10
The Nrf2 pathway in psychiatric disorders: pathophysiological role and potential targeting10
Targeting SHP2 phosphatase in hematological malignancies10
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)10
NTRK fusions in colorectal cancer: clinical meaning and future perspective10
An overview of novel antimicrobial carbonic anhydrase inhibitors10
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