Expert Opinion on Therapeutic Targets

Papers
(The TQCC of Expert Opinion on Therapeutic Targets is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)
ArticleCitations
lncRNAs: potential therapeutic targets and biomarkers for pancreatic cancer?107
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy55
Mitochondrial permeability transition pore: a snapshot of a therapeutic target47
Potential role of indole-3-propionic acid in tuberculosis: current perspectives and future prospects40
IL-36: a therapeutic target for ulcerative colitis?37
Calcium channelopathies in neurodegenerative disorder: an untold story of RyR and SERCA36
The clinical and immunological features of alopecia areata following SARS-CoV-2 infection or COVID-19 vaccines36
Interleukin-18 in cancer immunology and immunotherapy31
The sigma–1 receptor: a mechanistically–informed therapeutic target for antidepressants30
NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): seven years between lights and shadows30
Glycoproteins and longevity: an interview with Professor Gordan Lauc29
Axial spondyloarthritis: emerging drug targets29
Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications27
Pleural mesothelioma: a snapshot of emerging drug targets and opportunities for non-surgical therapeutic advancement26
Novel regulators of airway epithelial barrier function during inflammation: potential targets for drug repurposing26
MDA-9/Syntenin as a therapeutic cancer metastasis target: current molecular and preclinical understanding25
A short report on NGM282/aldafermin for the treatment of nonalcoholic steatohepatitis (NASH)25
PD-L1 and Notch as novel biomarkers in pancreatic sarcomatoid carcinoma: a pilot study24
The potential of multimolecular G-quadruplex structures for targeted treatment of Amyotrophic Lateral Sclerosis24
Current challenges in the discovery of treatments against Mayaro fever24
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets23
Clostridioides difficile: innovations in target discovery and potential for therapeutic success23
Kallikrein-related peptidases: mechanistic understanding for potential therapeutic targeting in cancer23
Therapeutic targeting of the polyglutamine androgen receptor in Spinal and Bulbar Muscular Atrophy22
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age22
KRAS mutations in colorectal cancer: impacts on tumor microenvironment and therapeutic implications21
The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?21
Bruton’s tyrosine kinase as a promising therapeutic target for multiple sclerosis21
Uncovering key targets of success for immunotherapy in pancreatic cancer20
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath20
Antibacterial carbonic anhydrase inhibitors targeting Vibrio cholerae enzymes20
Esophageal cancer: emerging therapeutics19
Novel signatures of prostate cancer progression and therapeutic resistance19
The challenges and potential of microRNA-based therapy for patients with liver failure syndromes and hepatocellular carcinoma19
What do we know about the renin angiotensin system and inflammatory bowel disease?18
The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin18
The sweet side of wound healing: galectins as promising therapeutic targets in hemostasis, inflammation, proliferation, and maturation/remodeling17
Progeria: a perspective on potential drug targets and treatment strategies16
Molecular pharmacology of multitarget cyclin-dependent kinase inhibitors in human colorectal carcinoma cells16
Hepatocellular carcinoma (HCC): the most promising therapeutic targets in the preclinical arena based on tumor biology characteristics16
Promising therapeutic targets for the treatment of urine storage dysfunction: what’s the status?15
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)15
Tenosynovial giant cell tumors (TGCT): molecular biology, drug targets and non-surgical pharmacological approaches15
ULK1 as a therapeutic target in kidney diseases: Current perspective14
Atypical teratoid rhabdoid tumor (ATRT): disease mechanisms and potential drug targets14
Targeting PRL phosphatases in hematological malignancies14
Targeting acid-sensing ion channels in glioblastoma: is there any therapeutic potential?14
Sjögren’s syndrome: shedding light on emerging and key drug targets14
Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABAB R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model14
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update14
GDF15: a potential therapeutic target for type 1 diabetes13
Retinal vein occlusion: drug targets and therapeutic implications13
Granzyme B as a therapeutic target: an update in 202213
Improving mitochondrial function in preclinical models of heart failure: therapeutic targets for future clinical therapies?13
Emerging therapeutic targets for anorexia nervosa13
Myocarditis: causes, mechanisms, and evolving therapies13
Myricetin, a natural inhibitor of CD147, increases sensitivity of cisplatin in ovarian cancer12
Mitochondria makeover: unlocking the path to healthy longevity12
The mechanisms and therapeutic targets of ferroptosis in cancer12
Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?12
Scavenger receptor A in immunity and autoimmune diseases: Compelling evidence for targeted therapy12
Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets12
Macrophages-microenvironment crosstalk in fibrostenotic inflammatory bowel disease: from basic mechanisms to clinical applications12
Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers12
What is the potential of formyl peptide receptor 1 (FPR1) as a therapeutic target in human disease?12
Hypoplastic left heart syndrome (HLHS): molecular pathogenesis and emerging drug targets for cardiac repair and regeneration11
Targeting BMPR-II in pulmonary arterial hypertension: a case of Hercules versus the Hydra?11
Targeting PCSK9 beyond the liver: evidence from experimental and clinical studies11
Bench-to-bedside investigations of H3 K27-altered diffuse midline glioma: drug targets and potential pharmacotherapies11
The role of collagen triple helix repeat containing 1 (CTHRC1) in cancer development and progression11
Nitric oxide pathway as a plausible therapeutic target in autism spectrum disorders11
Epigenetic regulatory mechanisms of histone acetylation in the treatment of cutaneous squamous cell carcinoma10
Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level10
An appraisal of emerging therapeutic targets for multiple sclerosis derived from current preclinical models10
TAR DNA-binding protein of 43 kDa (TDP-43) and amyotrophic lateral sclerosis (ALS): a promising therapeutic target10
Tackling retinal ganglion cell apoptosis in glaucoma: role of adenosine receptors10
Exosomes as a drug delivery tool for cancer therapy: a new era for existing drugs and oncolytic viruses10
The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies10
NTRK fusions in colorectal cancer: clinical meaning and future perspective10
Leveraging AI to identify dual-purpose aging and disease targets10
Expression of Concern: Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness10
The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential10
Cellular role of CD93 and its potential as a future therapeutic target10
Emerging therapeutic targets for epilepsy: preclinical insights10
The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state9
Virus-induced senescence: A therapeutic target to mitigate severe progression of SARS-COV-29
Considerations on the implementation of MAP4K4 inhibitors as cancer treatment9
Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles9
Medulloblastoma: novel insights into emerging therapeutic targets9
Shedding light on emerging therapeutic targets for chordoma9
ORF6, a repressor of the MHC class I pathway: new molecular target for SARS-CoV-2 drug discovery?9
Tumor-associated neutrophils: orchestrating cancer pathobiology and therapeutic resistance9
Ways of modulating GABA transporters to treat neurological disease9
Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment9
Neuromodulatory effects of SARS-CoV2 infection: Possible therapeutic targets9
Influence of the inflammasome complex on psychiatric disorders: clinical and preclinical studies9
Targeting the TRPV1 pain pathway in osteoarthritis of the knee9
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