OOIR: Observatory of International Research

Papers

(The TQCC of Lab on a Chip is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Front cover	214
Inside back cover	113
Contents list	103
Stepwise isolation of diverse metabolic cell populations using sorting by interfacial tension (SIFT)	101
Front cover	87
The reversible capillary field effect transistor: a capillaric element for autonomous flow switching	84
Study on the size and spatial configuration of liquid metal droplets in conductive hydrogels induced by surface acoustic waves	84
Microfluidic cell unroofing for the in situ molecular analysis of organelles without membrane permeabilization	83
Microfluidics for morpholomics and spatial omics applications	79
Time-resolved single-cell secretion analysis via microfluidics	79
Contents list	77
Placental microphysiological systems: new advances on promising platforms that mimic the microenvironment of the human placenta	71
High-throughput, combinatorial droplet generation by sequential spraying	67
Large-scale acoustic single cell trapping and selective releasing	67
A universal framework for design and manufacture of deterministic lateral displacement chips	65
A plug-and-play microfluidic device for hydrogel fiber spinning	60
Front cover	59
A vibrating capillary for ultrasound rotation manipulation of zebrafish larvae	58
A biosensor-integrated filtration device for nanoparticle isolation and label-free imaging	58
A miniprotein receptor electrochemical biosensor chip based on quantum dots	56
Fabrication of sac-like hydrogel membranes for replicating curved tissue barriers on chips	54
Configurable direction sensitivity of skin-mounted microfluidic strain sensor with auxetic metamaterial	54
On-demand photo-controlled motion enabled by solvent-driven mesogen alignment switch	53
3D nanoprinting of PDMS microvessels with tailored tortuosity and microporosity via direct laser writing	51
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Reagent free detection of SARS-CoV-2 using an antibody-based microwave sensor in a microfluidic platform	34
Front cover	34
3D-printed capillaric ELISA-on-a-chip with aliquoting	34
Hybrid skin chips for toxicological evaluation of chemical drugs and cosmetic compounds	33
Fluidic circuit board with modular sensor and valves enables stand-alone, tubeless microfluidic flow control in organs-on-chips	33
An integrated paper-based microfluidic platform for screening of early-stage Alzheimer's disease by detecting Aβ42	32
Sample-to-answer microfluidic device towards the point-of-need detection of Staphylococcus aureus enterotoxin genes in ruminant milk	32
Amplification-free CRISPR/Cas based dual-enzymatic colorimetric nucleic acid biosensing device	32
Two-dimensional micromodels for studying the convective dissolution of carbon dioxide in 2D water-saturated porous media	32
Inside front cover	31
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Integrated high performance microfluidic organic analysis instrument for planetary and space exploration	28

Contents list	28
Inside front cover	28
Advancing in situ single-cell microbiological analysis through a microwell droplet array with a gradual open sidewall	28
Front cover	28
Reversible bonding in thermoplastic elastomer microfluidic platforms for harvestable 3D microvessel networks	28
Luffa cylindrica-inspired powerless micropump: long-term, high-flow operation and energy-generation application	28
Advancing scalable and controllable multi-core droplet generation with double disturbance flow focusing	27
An intimal-lumen model in a microfluidic device: potential platform for atherosclerosis-related studies	27
Highly efficient combination of multiple single cells using a deterministic single-cell combinatorial reactor	27
Controlled Au-coated PDMS microwell array for surface-enhanced DNA biochips	27
Optofluidic lasers and their applications in biochemical sensing	26
High-precision, low-complexity, high-resolution microscopy-based cell sorting	26
Dispersive phase microscopy incorporated with droplet-based microfluidics for biofactory-on-a-chip	26
Heterogeneous tissue construction by on-demand bubble-assisted acoustic patterning	26
Opportunities and considerations for studying liver disease with microphysiological systems on a chip	26
Detecting telomerase activity at the single-cell level using a CRISPR-Cas12a-based chip	26
A combinatorial droplet microfluidic device integrated with mass spectrometry for enzyme screening	25
Microfluidic device combining hydrodynamic and dielectrophoretic trapping for the controlled contact between single micro-sized objects and application to adhesion assays	25
Real-time spectroscopic monitoring of continuous-flow synthesis of zinc oxide nano-structures in femtosecond laser fabricated 3D microfluidic microchannels with integrated on-chip fiber probe array	25
Robust fully controlled nanometer liquid layers for high resolution liquid-cell electron microscopy	25
Acoustofluidic large-scale mixing for enhanced microfluidic immunostaining for tissue diagnostics	25
Fabrication of ITO microelectrodes and electrode arrays using a low-cost CO₂ laser plotter	24
Controlling amorphous silicon in scratching for fabricating high-performance micromixers	24
Utilizing ChatGPT to assist CAD design for microfluidic devices	24
Generating signals at converging liquid fronts to create line-format readouts of soluble assay products in three-dimensional paper-based devices	24
Design and build a green tent environment for growing and charactering mycelium growth in lab	24
Automated electrokinetic stretcher for manipulating nanomaterials	24
Dynamic nano-imaging via a microsphere compound lens integrated microfluidic device with a 10× objective lens	24
High-throughput adjustable deformability cytometry utilizing elasto-inertial focusing and virtual fluidic channel	23
Manipulation of cancer cells in a sessile dropletviatravelling surface acoustic waves	23
Microfluidic device-fabricated spiky nano-burflower shape gold nanomaterials facilitate large biomolecule delivery into cells using infrared light pulses	23
Millifluidic valves and pumps made of tape and plastic	23
Micro- and nanosystems for the detection of hemorrhagic fever viruses	23
Controlling bead and cell mobility in a recirculating hanging-drop network	23
Ultra-thin and ultra-porous nanofiber networks as a basement-membrane mimic	23
On-chip miRNA extraction platforms: recent technological advances and implications for next generation point-of-care nucleic acid tests	23
Structured-light-sheet imaging in an integrated optofluidic platform	22
In situ spatiotemporal characterization and analysis of chemical reactions using an ATR-integrated microfluidic reactor	22
Measuring the electrophoretic mobility and size of single particles using microfluidic transverse AC electrophoresis (TrACE)	22
Grease the gears: how lubrication of syringe pumps impacts microfluidic flow precision	22
Combinatorial nanodroplet platform for screening antibiotic combinations	22
A biomimetic renal fibrosis progression model on-chip evaluates anti-fibrotic effects longitudinally in a dynamic fibrogenic niche	22
A magnetic microneedle to isolate single immunomagnetically labeled cells	22
High-performance magnetic metal microrobot prepared by a two-photon polymerization and sintering method	22
Design of a multilayer lung chip with multigenerational alveolar ducts to investigate the inhaled particle deposition	22
Single-cell patterning and characterisation of antibiotic persistent bacteria using bio-sCAPA	22
A multi-functional microfluidic device compatible with widefield and light sheet microscopy	22
Accelerated protein digestion and separation with picoliter volume utilizing nanofluidics	22
Contactless acoustic tweezer for droplet manipulation on superhydrophobic surfaces	22
Continuous-flow electrorotation (cROT): improved throughput characterization for dielectric properties of cancer cells	21
Antibody mediated cotton-archetypal substrate for enumeration of circulating tumor cells and chemotherapy outcome in 3D tumors	21
Acousto-optofluidic 3D single cell imaging of macrophage phagocytosis of Pseudomonas Aeruginosa	21
Programmable motion control and trajectory manipulation of microparticles through tri-directional symmetrical acoustic tweezers	21
Brain stimulation-on-a-chip: a neuromodulation platform for brain slices	21
Desktop-level small automatic guided vehicle driven by a liquid metal droplet	21
A versatile and automated microfluidic platform for a quantitative magnetic bead based protocol: application to gluten detection	20
3D-printed microfluidic device for high-throughput production of lipid nanoparticles incorporating SARS-CoV-2 spike protein mRNA	20
On the acoustically induced fluid flow in particle separation systems employing standing surface acoustic waves – Part I	20
The crystal orientation of THF clathrates in nano-confinement by in situ polarized Raman spectroscopy	20
In-line measurement of liquid–liquid phase separation boundaries using a turbidity-sensor-integrated continuous-flow microfluidic device	20
Horizontal and vertical microchamber platforms for evaluation of the paracellular permeability of an epithelial cell monolayer	20
CoreView: fresh tissue biopsy assessment at the bedside using a millifluidic imaging chip	20
Programmable metachronal motion of closely packed magnetic artificial cilia	20
Label-free cell classification in holographic flow cytometry through an unbiased learning strategy	20
Designing for simplicity: lessons from Mesa Biotech for microfluidic entrepreneurs and early-stage companies	20
Geometry and length control of 3D engineered heart tissues using direct laser writing	19
Integrated biocompatible 3D printed isoporous membranes with 7 μm pores	19
Miniature fluorescence sensor for quantitative detection of brain tumour	19
Microfluidic device for single step measurement of protein C in plasma samples for sepsis prognosis	19
Quantitative mechanical stimulation of GPR68 using a novel 96 well flow plugin	19
Bio-inspired progressive motile sperm separation using joint rheotaxis and boundary-following behavior	19
Microfluidic finger-actuated mixer for ultrasensitive electrochemical measurements of protein biomarkers for point-of-care testing	18
Development of a self-powered digital LAMP microfluidic chip (SP-dChip) for the detection of emerging viruses	18
Modelling the innate immune system in microphysiological systems	18
Digital manufacturing for accelerating organ-on-a-chip dissemination and electrochemical biosensing integration	18
Impact of brain organoid-derived sEVs on metastatic adaptation and invasion of breast carcinoma cells through a microphysiological system	18
On the acoustically induced fluid flow in particle separation systems employing standing surface acoustic waves – Part II	18
Rapid nucleic acid extraction from skin biopsies using a point-of-care device	18
Electrolyte-gated amorphous IGZO transistors with extended gates for prostate-specific antigen detection	18
Urine osmolality assessment through the integration of urea hydrolysis and impedance measurement	18

DLM–GelMA/tumor slice sandwich structured tumor on a chip for drug efficacy testing	18
Site-specific thrombus formation: advancements in photothrombosis-on-a-chip technology	18
An ultra-thin flexible wearable sensor with multi-response capability prepared from ZIF-67 and conductive metal–organic framework composites for health signal monitoring	18
Patterned thin film enzyme electrodes via spincoating and glutaraldehyde vapor crosslinking: towards scalable fabrication of integrated sensor-on-CMOS devices	18
A review of optoelectrowetting (OEW): from fundamentals to lab-on-a-smartphone (LOS) applications to environmental sensors	18
3D printing of monolithic gravity-assisted step-emulsification device for scalable production of high viscosity emulsion droplets	18
Low yield stress measurements with a microfluidic rheometer	17
Impact of microchannel width on axons for brain-on-chip applications	17
An agarose fluidic chip for high-throughput in toto organoid imaging	17
Recapitulation of dynamic nanoparticle transport around tumors using a triangular multi-chamber tumor-on-a-chip	17
Advancing cellular transfer printing: achieving bioadhesion-free deposition via vibration microstreaming	17
Liquid metal droplet motion transferred from an alkaline solution by a robot arm	17
Antigen density and applied force control enrichment of nanobody-expressing yeast cells in microfluidics	17
3D printed field-deployable microfluidic systems for the separation and assay of Pu in nuclear forensics	17
Reusable EWOD-based microfluidic system for active droplet generation	17
Axons-on-a-chip for mimicking non-disruptive diffuse axonal injury underlying traumatic brain injury	16
An integrated nucleic acid detection method based on a microfluidic chip for collection and culture of rice false smut spores	16
Bending Drosophila larva using a microfluidic device enables imaging of its brain and nervous system at single neuronal resolution	16
OMEF biochip for evaluating red blood cell deformability using dielectrophoresis as a diagnostic tool for type 2 diabetes mellitus	16
Dynamic sampling from ex vivo adipose tissue using droplet-based microfluidics supports separate mechanisms for glycerol and fatty acid secretion	16
Size-related variability of oxygen consumption rates in individual human hepatic cells	16
Study on the hemodynamic effects of different pulsatile working modes of a rotary blood pump using a microfluidic platform that realizes in vitro cell culture effectively	16
Improved Teflon lift-off for droplet microarray generation and single-cell separation on digital microfluidic chips	16
A machine learning-based framework to design capillary-driven networks	16
The egg-counter: a novel microfluidic platform for characterization of Caenorhabditis elegans egg-laying	16
Binding properties of flowing fibrin-targeted microbubbles evaluated with a thrombus-embedded microchannel	16
Screening for urothelial carcinoma cells in urine based on digital holographic flow cytometry through machine learning and deep learning methods	16
Lab-on-a-chip technologies for minimally invasive molecular sensing of diabetic retinopathy	16
Point-of-care SARS-CoV-2 sensing using lens-free imaging and a deep learning-assisted quantitative agglutination assay	16
Investigation of particle manipulation mechanism and size sorting strategy in a double-layered microchannel	16
Deformation under flow and morphological recovery of cancer cells	16
A nanobody-based microfluidic chip for fast and automated purification of protein complexes	16
Image-based cell sorting using focused travelling surface acoustic waves	16
Miniaturized sensor for electroanalytical and electrochemiluminescent detection of pathogens enabled through laser-induced graphene electrodes embedded in microfluidic channels	16
Flowmetering for microfluidics	16
An integrated microfluidic device for sorting of tumor organoids using image recognition	16
Droplet drinking in constrictions	16
Microfabricated acoustofluidic membrane acoustic waveguide actuator for highly localized in-droplet dynamic particle manipulation	15
Enhanced podocyte differentiation and changing drug toxicity sensitivity through pressure-controlled mechanical filtration stress on a glomerulus-on-a-chip	15
Emulating clinical pressure waveforms in cell culture using an Arduino-controlled millifluidic 3D-printed platform for 96-well plates	15
A multiscale, vertical-flow perfusion system with integrated porous microchambers for upgrading multicellular spheroid culture	15
Back cover	15
Correction: Organ-on-a-chip with integrated semitransparent organic electrodes for barrier function monitoring	15
Open-channel microfluidic chip based on shape memory polymer for controllable liquid transport	15
Non-fouling polymer brush grafted fluorine-doped tin oxide enabled optical and chemical enhancement for sensitive label-free antibody microarrays	15
Virtual-freezing fluorescence imaging flow cytometry with 5-aminolevulinic acid stimulation and antibody labeling for detecting all forms of circulating tumor cells	15
Cells function as a ternary logic gate to decide migration direction under integrated chemical and fluidic cues	15
Introduction to Lab on a Chip Reviews issue	15
Integration of silicon chip microstructures for in-line microbial cell lysis in soft microfluidics	15
Front cover	15
Correction: Antibody-coated microstructures for selective isolation of immune cells in blood	15
Facile construction of a 3D tumor model with multiple biomimetic characteristics using a micropatterned chip for large-scale chemotherapy investigation	15
Passive redirection filters minimize red blood cell contamination during neutrophil chemotaxis assays using whole blood	15
Collection, nucleic acid release, amplification, and visualization platform for rapid field detection of rice false smut	15
Pivot, persevere, or perish: how Ellume Health overcame development and regulatory obstacles to become the first authorized over-the-counter COVID-19 test in the United States	15
On-demand liquid microlens arrays by non-contact relocation of inhomogeneous fluids in acoustic fields	15
Development of a microfluidic device to observe dynamic flow around the villi generated by deformation of small intestinal tissue	15
Front cover	15
Correction: Developing an advanced gut on chip model enabling the study of epithelial cell/fibroblast interactions	15
Integrated membrane-free thermal flow sensor for silicon-on-glass microfluidics	15
Microwell array chip-based single-cell analysis	14
Proof-of-concept optimization of a copper-mediated ¹⁸F-radiosynthesis of a novel MAGL PET tracer on a high-throughput microdroplet platform and its macroscale translation	14
Capturing the spatial and temporal dynamics of tumor stroma for on-chip optimization of microenvironmental targeting nanomedicine	14
Integrating machine learning and digital microfluidics for screening experimental conditions	14
On-board smartphone micromotor-based fluorescence assays	14
Microfluidic confined acoustic streaming vortex for liposome synthesis	14
Under-oil open microfluidic systems for rapid phenotypic antimicrobial susceptibility testing	14
Label-free single-cell antimicrobial susceptibility testing in droplets with concentration gradient generation	14
Droplet microfluidics for functional temporal analysis and cell recovery on demand using microvalves: application in immunotherapies for cancer	14
Inside back cover	14
Automation of cell culture assays using a 3D-printed servomotor-controlled microfluidic valve system	14
A survey of 3D printing technology applied to paper microfluidics	14
A syndromic diagnostic assay on a macrochannel-to-digital microfluidic platform for automatic identification of multiple respiratory pathogens	14
Development of a simultaneous electrorotation device with microwells for monitoring the rotation rates of multiple single cells upon chemical stimulation	14
Sensor-integrated gut-on-a-chip for monitoring senescence-mediated changes in the intestinal barrier	14
Enhanced motility and interaction of nasopharyngeal carcinoma with epithelial cells in confined microwells	13
Visualization investigation of fluid transport in multiscale porous media for CO₂-EOR based on microfluidic technology	13
Lab-on-a-chip models of the blood–brain barrier: evolution, problems, perspectives	13
Automated sample-to-answer centrifugal microfluidic system for rapid molecular diagnostics of SARS-CoV-2	13
Islet-on-chip: promotion of islet health and functionviaencapsulation within a polymerizable fibrillar collagen scaffold	13
Sub-wavelength acoustic stencil for tailored micropatterning	13
Smart salt-responsive thread for highly sensitive microfluidic glucose detection in sweat	13
Inside front cover	13
Pump-less, recirculating organ-on-a-chip (rOoC) platform	13
Heart-on-a-chip systems: disease modeling and drug screening applications	13
Rapid and easily identifiable blood typing on microfluidic cotton thread-based analytical devices	13
Office paper and laser printing: a versatile and affordable approach for fabricating paper-based analytical devices with multimodal detection capabilities	13
Chip-integrated non-mechanical microfluidic pump driven by electrowetting on dielectrics	13
Hydrogel particles-on-chip (HyPoC): a fluorescence micro-sensor array for IgG immunoassay	13
Microfluidic platforms for extracellular vesicle isolation, analysis and therapy in cancer	13
Forced air oscillations – pneumatic capacitance in microfluidic oscillators produces non-linear responses and emergent behaviors	13
Tailored point-of-care biosensors for liquid biopsy in the field of oncology	13
Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models	13
Twenty years of islet-on-a-chip: microfluidic tools for dissecting islet metabolism and function	13
Developing a transwell millifluidic device for studying blood–brain barrier endothelium	13