Lab on a Chip

Article	Citations
Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature	158
Point-of-care testing detection methods for COVID-19	152
An outlook on microfluidics: the promise and the challenge	122
Conventional and emerging strategies for the fabrication and functionalization of PDMS-based microfluidic devices	118
High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows	111
Single-cell microfluidic impedance cytometry: from raw signals to cell phenotypes using data analytics	110
A microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay for rapid COVID-19 detection	104
Engineering neurovascular organoids with 3D printed microfluidic chips	76
Accelerating innovation and commercialization through standardization of microfluidic-based medical devices	74
Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures	68
Recent innovations in cost-effective polymer and paper hybrid microfluidic devices	65
Anin vitrovascularized micro-tumor model of human colorectal cancer recapitulatesin vivoresponses to standard-of-care therapy	61
Controllable fusion of human brain organoids using acoustofluidics	59
Simulating drug concentrations in PDMS microfluidic organ chips	57
HiPSC-derived multi-organoids-on-chip system for safety assessment of antidepressant drugs	57
Microfluidic-based capture and release of cancer-derived exosomes via peptide–nanowire hybrid interface	57
Understanding and improving FDM 3D printing to fabricate high-resolution and optically transparent microfluidic devices	55
Standardisation needs for organ on chip devices	54
Autonomous lab-on-paper for multiplexed, CRISPR-based diagnostics of SARS-CoV-2	52
A flux-adaptable pump-free microfluidics-based self-contained platform for multiplex cancer biomarker detection	52
A high-throughput multiplexed microfluidic device for COVID-19 serology assays	52
Developing an advanced gut on chip model enabling the study of epithelial cell/fibroblast interactions	51
Neural network-enhanced real-time impedance flow cytometry for single-cell intrinsic characterization	49
Multiphysics microfluidics for cell manipulation and separation: a review	49
A thread/fabric-based band as a flexible and wearable microfluidic device for sweat sensing and monitoring	48

Engineering a sustainable future for point-of-care diagnostics and single-use microfluidic devices	47
The acoustic droplet printing of functional tumor microenvironments	47
Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out	46
Microfluidic technologies for nanoparticle formation	46
Bubbles in microfluidics: an all-purpose tool for micromanipulation	43
Liquid marble-based digital microfluidics – fundamentals and applications	43
Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?	43
Machine learning for microfluidic design and control	43
Tubular human brain organoids to model microglia-mediated neuroinflammation	43
Speeding up reconstruction of 3D tomograms in holographic flow cytometry via deep learning	42
Printed microfluidic sweat sensing platform for cortisol and glucose detection	42
Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant read-outs for tissue permeability and vascular structure	41
Self-powered droplet manipulation system for microfluidics based on triboelectric nanogenerator harvesting rotary energy	41
Extracellular vesicle mediated feto-maternal HMGB1 signaling induces preterm birth	41
Membrane integration into PDMS-free microfluidic platforms for organ-on-chip and analytical chemistry applications	40
Thin-film-transistor digital microfluidics for high value in vitro diagnostics at the point of need	40
“One-to-three” droplet generation in digital microfluidics for parallel chemiluminescence immunoassays	40
Biomedical optical fibers	39
Advances in microfluidic extracellular vesicle analysis for cancer diagnostics	38
Plasmonic nanobowtiefluidic device for sensitive detection of glioma extracellular vesicles by Raman spectrometry	38
Liver organ-on-chip models for toxicity studies and risk assessment	38
High throughput transepithelial electrical resistance (TEER) measurements on perfused membrane-free epithelia	37
Interfacing cells with organic transistors: a review ofin vitroandin vivoapplications	37
Materials and methods for droplet microfluidic device fabrication	37
User-friendly image-activated microfluidic cell sorting technique using an optimized, fast deep learning algorithm	36
Tumor-on-a-chip platforms to study cancer–immune system crosstalk in the era of immunotherapy	36
Nanoparticle protein corona: from structure and function to therapeutic targeting	36
Unconventional acoustic approaches for localized and designed micromanipulation	36
Fiber optic hydrogen sensor based on a Fabry–Perot interferometer with a fiber Bragg grating and a nanofilm	36
Inertial microfluidics: current status, challenges, and future opportunities	36
Microliter ultrafast centrifuge platform for size-based particle and cell separation and extraction using novel omnidirectional spiral surface acoustic waves	35
Intelligent acoustofluidics enabled mini-bioreactors for human brain organoids	35
Biologically inspired micro-robotic swimmers remotely controlled by ultrasound waves	35
Simple and fast isolation of circulating exosomes with a chitosan modified shuttle flow microchip for breast cancer diagnosis	34
A 3D human adipose tissue model within a microfluidic device	34
Microscopic artificial cilia – a review	34
Point-of-care diagnostics: recent developments in a pandemic age	34
Label-free microfluidic cell sorting and detection for rapid blood analysis	34
A multilayered blood vessel/tumor tissue chip to investigate T cell infiltration into solid tumor tissues	33
Nonlinear microfluidics: device physics, functions, and applications	33
3D printed microfluidics: advances in strategies, integration, and applications	33
Deciphering impedance cytometry signals with neural networks	33
Cascaded filter deterministic lateral displacement microchips for isolation and molecular analysis of circulating tumor cells and fusion cells	33
Direct isolation of circulating extracellular vesicles from blood for vascular risk profiling in type 2 diabetes mellitus	33
Microdissected “cuboids” for microfluidic drug testing of intact tissues	33
Gear-shaped micromixer for synthesis of silica particles utilizing inertio-elastic flow instability	32
Submicron-precision particle characterization in microfluidic impedance cytometry with double differential electrodes	32
Simultaneous single-cell phenotype analysis of hepatocellular carcinoma CTCs using a SERS-aptamer based microfluidic chip	32
Ultraviolet-induced in situ gold nanoparticles for point-of-care testing of infectious diseases in loop-mediated isothermal amplification	32
Review: tomographic imaging flow cytometry	31

Retinal organoids on-a-chip: a micro-millifluidic bioreactor for long-term organoid maintenance	31
Tailored point-of-care biosensors for liquid biopsy in the field of oncology	31
Lateral flow assays for hormone detection	31
A novel human arterial wall-on-a-chip to study endothelial inflammation and vascular smooth muscle cell migration in early atherosclerosis	31
Review of microfluidic approaches for fabricating intelligent fiber devices: importance of shape characteristics	31
A digital protein microarray for COVID-19 cytokine storm monitoring	30
A microfluidic cathodic photoelectrochemical biosensor chip for the targeted detection of cytokeratin 19 fragments 21-1	30
Recent advances in the microfluidic production of functional microcapsules by multiple-emulsion templating	30
Fabrication of tunable, high-molecular-weight polymeric nanoparticles via ultrafast acoustofluidic micromixing	30
A portable, 3D printed, microfluidic device for multiplexed, real time, molecular detection of the porcine epidemic diarrhea virus, transmissible gastroenteritis virus, and porcine deltacoronavirus at	30
Rapid and precise tumor cell separation using the combination of size-dependent inertial and size-independent magnetic methods	30
Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers	30
Construction of a high fidelity epidermis-on-a-chip for scalable in vitro irritation evaluation	29
An electricity- and instrument-free infectious disease sensor based on a 3D origami paper-based analytical device	29
Real-time isothermal DNA amplification monitoring in picoliter volumes using an optical fiber sensor	29
Microfluidic platforms for extracellular vesicle isolation, analysis and therapy in cancer	29
A fully transparent, flexible PEDOT:PSS–ITO–Ag–ITO based microelectrode array for ECoG recording	29
Wearable chem-biosensing devices: from basic research to commercial market	29
FertDish: microfluidic sperm selection-in-a-dish for intracytoplasmic sperm injection	29
An integrated microfluidic system for early detection of sepsis-inducing bacteria	29
Recent advances in lab-on-paper diagnostic devices using blood samples	29
Sensing morphogenesis of bone cells under microfluidic shear stress by holographic microscopy and automatic aberration compensation with deep learning	29
Recent progress on wearable point-of-care devices for ocular systems	28
In vitro assay for single-cell characterization of impaired deformability in red blood cells under recurrent episodes of hypoxia	28
Investigations on T cell transmigration in a human skin-on-chip (SoC) model	28
Vasculature-on-a-chip platform with innate immunity enables identification of angiopoietin-1 derived peptide as a therapeutic for SARS-CoV-2 induced inflammation	28
Interstitial flow enhances the formation, connectivity, and function of 3D brain microvascular networks generated within a microfluidic device	28
Microfluidic channel integrated with a lattice lightsheet microscopic system for continuous cell imaging	28
A 3-dimensional microfluidic platform for modeling human extravillous trophoblast invasion and toxicological screening	27
Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion	27
Automated biophysical classification of apoptotic pancreatic cancer cell subpopulations by using machine learning approaches with impedance cytometry	27
Fabrication of monodisperse alginate microgel beads by microfluidic picoinjection: a chelate free approach	27
A rapid nucleic acid concentration measurement system with large field of view for a droplet digital PCR microfluidic chip	27
Rapid nitrate determination with a portable lab-on-chip device based on double microstructured assisted reactors	26
Slip formation of a high-density droplet array for nucleic acid quantification by digital LAMP with a random-access system	26
A simple and reversible glass–glass bonding method to construct a microfluidic device and its application for cell recovery	26
Inertial focusing of circulating tumor cells in whole blood at high flow rates using the microfluidic CTCKey™ device for CTC enrichment	26
Recent advances in integrated solid-state nanopore sensors	26
3-D swimming microdrone powered by acoustic bubbles	26
Measuring barrier function in organ-on-chips with cleanroom-free integration of multiplexable electrodes	25
Microfluidic formation of crystal-like structures	25
Microfluidic-based in vitro thrombosis model for studying microplastics toxicity	25
Immuno-biosensor on a chip: a self-powered microfluidic-based electrochemical biosensing platform for point-of-care quantification of proteins	25
A graphene oxide coated tapered microfiber acting as a super-sensor for rapid detection of SARS-CoV-2	25
Microfluidic point-of-care device for detection of early strains and B.1.1.7 variant of SARS-CoV-2 virus	25
A sample-to-answer, quantitative real-time PCR system with low-cost, gravity-driven microfluidic cartridge for rapid detection of SARS-CoV-2, influenza A/B, and human papillomavirus 16/18	25
Establishment of a human three-dimensional chip-based chondro-synovial coculture joint model for reciprocal cross talk studies in arthritis research	25
Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies	25
Integration of segmented microflow chemistry and online HPLC/MS analysis on a microfluidic chip system enabling enantioselective analyses at the nanoliter scale	24
Deep imaging flow cytometry	24
A microfluidic device enabling deterministic single cell trapping and release	24
Tuning particle inertial separation in sinusoidal channels by embedding periodic obstacle microstructures	24
Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy	24
Three-dimensional imaging on a chip using optofluidics light-sheet fluorescence microscopy	24
A robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology	24
Enzyme-based digital bioassay technology – key strategies and future perspectives	24
Bacterial classification and antibiotic susceptibility testing on an integrated microfluidic platform	24
Tunnel dielectrophoresis for ultra-high precision size-based cell separation	24
Acoustic valves in microfluidic channels for droplet manipulation	24
Emerging point-of-care technologies for anemia detection	23
Postoperative evaluation of tumours based on label-free acoustic separation of circulating tumour cells by microstreaming	23
A microfluidic chip with a serpentine channel enabling high-throughput cell separation using surface acoustic waves	23
Cancer drug screening with an on-chip multi-drug dispenser in digital microfluidics	23
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips	23
Microneedle-based transdermal detection and sensing devices	23
Closed-loop feedback control of microfluidic cell manipulation via deep-learning integrated sensor networks	23
Oxygen control: the often overlooked but essential piece to create betterin vitrosystems	23
Recent microfluidic advances in submicron to nanoparticle manipulation and separation	23
On-chip rapid drug screening of leukemia cells by acoustic streaming	23
Isolation and recovery of extracellular vesicles using optically-induced dielectrophoresis on an integrated microfluidic platform	23
A fully integrated biomimetic microfluidic device for evaluation of sperm response to thermotaxis and chemotaxis	22
Engineering a deformation-free plastic spiral inertial microfluidic system for CHO cell clarification in biomanufacturing	22
High-throughput injection molded microfluidic device for single-cell analysis of spatiotemporal dynamics	22
Microfluidic droplet-based functional materials for cell manipulation	22
Focused surface acoustic wave locally removes cells from culture surface	22
Microfluidic model with air-walls reveals fibroblasts and keratinocytes modulate melanoma cell phenotype, migration, and metabolism	22
A review on microrobots driven by optical and magnetic fields	22
Optimized design of obstacle sequences for microfluidic mixing in an inertial regime	22
Stromal cell identity modulates vascular morphogenesis in a microvasculature-on-a-chip platform	22
Assessing red blood cell deformability from microscopy images using deep learning	22

Rapid isolation of circulating cancer associated fibroblasts by acoustic microstreaming for assessing metastatic propensity of breast cancer patients	22
Multi-oscillation microrheology via acoustic force spectroscopy enables frequency-dependent measurements on endothelial cells at high-throughput	22
Zigzag microchannel for rigid inertial separation and enrichment (Z-RISE) of cells and particles	22
A microphysiological early metastatic niche on a chip reveals how heterotypic cell interactions and inhibition of integrin subunit β3 impact breast cancer cell extravasation	22
Label-free inertial-ferrohydrodynamic cell separation with high throughput and resolution	22
On the acoustically induced fluid flow in particle separation systems employing standing surface acoustic waves – Part I	22
Advances in droplet digital polymerase chain reaction on microfluidic chips	21
Flowmetering for microfluidics	21
Blood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research	21
Multi-parametric functional imaging of cell cultures and tissues with a CMOS microelectrode array	21
Predicting the fluid behavior of random microfluidic mixers using convolutional neural networks	21
Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip	21
Machine learning assisted fast prediction of inertial lift in microchannels	21
Intestinal explant barrier chip: long-term intestinal absorption screening in a novel microphysiological system using tissue explants	21
A continuous flow PCR array microfluidic chip applied for simultaneous amplification of target genes of periodontal pathogens	21
Disposable photonics for cost-effective clinical bioassays: application to COVID-19 antibody testing	21
Human neuromuscular junction on micro-structured microfluidic devices implemented with a custom micro electrode array (MEA)	21
Technologies for measuring red blood cell deformability	21
Generation of flow and droplets with an ultra-long-range linear concentration gradient	21
A microfluidic cartridge for fast and accurate diagnosis of Mycobacterium tuberculosis infections on standard laboratory equipment	21
Size-tuneable isolation of cancer cells using stretchable inertial microfluidics	21
Recent advances in microfluidic devices for single-cell cultivation: methods and applications	21
High-throughput and label-free enrichment of malignant tumor cells and clusters from pleural and peritoneal effusions using inertial microfluidics	21
Engineering inclined orientations of piezoelectric films for integrated acoustofluidics and lab-on-a-chip operated in liquid environments	20
Parallel multistep digital analysis SlipChip demonstrated with the quantification of nucleic acid by digital LAMP-CRISPR	20
Versatile acoustic manipulation of micro-objects using mode-switchable oscillating bubbles: transportation, trapping, rotation, and revolution	20
Spatial trans-epithelial electrical resistance (S-TEER) integrated in organs-on-chips	20
Self-aligned sequential lateral field non-uniformities over channel depth for high throughput dielectrophoretic cell deflection	20
Healthy and diseased in vitro models of vascular systems	20
Practical microcircuits for handheld acoustofluidics	20
Development of a human neuromuscular tissue-on-a-chip model on a 24-well-plate-format compartmentalized microfluidic device	20
Biohybrid sensor for odor detection	20
Lab-in-a-pencil graphite: A 3D-printed microfluidic sensing platform for real-time measurement of antipsychotic clozapine level	20
Microfluidic technologies for immunotherapy studies on solid tumours	20
Cell-sorting centrifugal microfluidic chip with a flow rectifier	20
Microfluidics for antibiotic susceptibility testing	19
A polymer index-matched to water enables diverse applications in fluorescence microscopy	19
Automated fluorescence quantification of extracellular vesicles collected from blood plasma using dielectrophoresis	19
3D micromixer for nanoliposome synthesis: a promising advance in high mass productivity	19
Programmable motion control and trajectory manipulation of microparticles through tri-directional symmetrical acoustic tweezers	19
Bridging the academic–industrial gap: application of an oxygen and pH sensor-integrated lab-on-a-chip in nanotoxicology	19
Multiplex amplification of target genes of periodontal pathogens in continuous flow PCR microfluidic chip	19
Flexural wave-based soft attractor walls for trapping microparticles and cells	19
On-chip perivascularnichesupporting stemness of patient-derived glioma cells in a serum-free, flowable culture	19
Automated sample-to-answer centrifugal microfluidic system for rapid molecular diagnostics of SARS-CoV-2	19
A photofabricated honeycomb micropillar array for loss-free trapping of microfluidic droplets and application to digital PCR	19
An epidermal wearable microfluidic patch for simultaneous sampling, storage, and analysis of biofluids with counterion monitoring	19
Point-of-care microchip electrophoresis for integrated anemia and hemoglobin variant testing	19
Dosage-controlled intracellular delivery mediated by acoustofluidics for lab on a chip applications	19
IL-2 secretion-based sorting of single T cells using high-throughput microfluidic on-cell cytokine capture	18
Lateral flow device for water fecal pollution assessment: from troubleshooting of its microfluidics using bioluminescence to colorimetric monitoring of generic Escherichia coli	18
High-throughput digital pathology via a handheld, multiplexed, and AI-powered ptychographic whole slide scanner	18
High performance inkjet printed embedded electrochemical sensors for monitoring hypoxia in a gut bilayer microfluidic chip	18
Quantitative particle agglutination assay for point-of-care testing using mobile holographic imaging and deep learning	18
Small intestinal sampling capsule for inflammatory bowel disease type detection and management	18
Digital electrical impedance analysis for single bacterium sensing and antimicrobial susceptibility testing	18
An “occlusive thrombosis-on-a-chip” microfluidic device for investigating the effect of anti-thrombotic drugs	18
An antibiotic concentration gradient microfluidic device integrating surface-enhanced Raman spectroscopy for multiplex antimicrobial susceptibility testing	18
Microfluidic single-cell transcriptomics: moving towards multimodal and spatiotemporal omics	18
Bio-inspired fractal textile device for rapid sweat collection and monitoring	18
Application of a gut–liver-on-a-chip device and mechanistic modelling to the quantitative in vitro pharmacokinetic study of mycophenolate mofetil	18
Surfactant-laden droplet size prediction in a flow-focusing microchannel: a data-driven approach	18
A sequentially bioconjugated optofluidic laser for wash-out-free and rapid biomolecular detection	18
Efficient and gentle delivery of molecules into cells with different elasticity via Progressive Mechanoporation	18
Monitoring the effects of chemical stimuli on live cells with metasurface-enhanced infrared reflection spectroscopy	18
Advanced continuous-flow microfluidic device for parallel screening of crystal polymorphs, morphology, and kinetics at controlled supersaturation	17
Microfluidic acoustic sawtooth metasurfaces for patterning and separation using traveling surface acoustic waves	17
Integrated microfluidic platform with electrohydrodynamic focusing and a carbon-nanotube-based field-effect transistor immunosensor for continuous, selective, and label-free quantification of bacteria	17
Scaffold-free generation of heterotypic cell spheroids using acoustofluidics	17
Cilo-seq: highly sensitive cell-in-library-out single-cell transcriptome sequencing with digital microfluidics	17
Fluidic circuit board with modular sensor and valves enables stand-alone, tubeless microfluidic flow control in organs-on-chips	17
Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems	17
Super-resolution optofluidic scanning microscopy	17
Label-free detection and enumeration of rare circulating tumor cells by bright-field image cytometry and multi-frame image correlation analysis	17
Microfluidic studies of hydrostatic pressure-enhanced doxorubicin resistance in human breast cancer cells	17
Shape-based separation of drug-treated Escherichia coli using viscoelastic microfluidics	17
Flow shear stress controls the initiation of neovascularization via heparan sulfate proteoglycans within a biomimetic microfluidic model	17
Microfluidic generation of ATPS droplets by transient double emulsion technique	17
Low-cost rapid prototyping and assembly of an open microfluidic device for a 3D vascularized organ-on-a-chip	17
Hotspots of root-exuded amino acids are created within a rhizosphere-on-a-chip	17
Deep learning detector for high precision monitoring of cell encapsulation statistics in microfluidic droplets	17
Sheathless and high-throughput elasto-inertial bacterial sorting for enhancing molecular diagnosis of bloodstream infection	17
Origami paper-based sample preconcentration using sequentially driven ion concentration polarization	17
Counting of enzymatically amplified affinity reactions in hydrogel particle-templated drops	16
On-board smartphone micromotor-based fluorescence assays	16
A microfluidic hanging drop-based spheroid co-culture platform for probing tumor angiogenesis	16
High-throughput microfluidic compressibility cytometry using multi-tilted-angle surface acoustic wave	16
Active single cell encapsulation using SAW overcoming the limitations of Poisson distribution	16
Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy	16
Mechanotransduction-on-chip: vessel-chip model of endothelial YAP mechanobiology reveals matrix stiffness impedes shear response	16
Extraction of small extracellular vesicles by label-free and biocompatible on-chip magnetic separation	16
Selection of high-quality sperm with thousands of parallel channels	16
Sub-micron thick liquid sheets produced by isotropically etched glass nozzles	16
Label-free three-dimensional observations and quantitative characterisation of on-chip vasculogenesis using optical diffraction tomography	16
Portable sample processing for molecular assays: application to Zika virus diagnostics	16