OOIR: Observatory of International Research

Papers

(The TQCC of Expert Review of Molecular Diagnostics is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Harnessing the potential of genomic characterization of mutational profiles to improve early diagnosis of lung cancer	120
Clinicopathological, etiological and molecular characteristics of intrahepatic cholangiocarcinoma subtypes classified by mucin production and immunohistochemical features	92
Evolution and future of cervical cancer screening: from cytology to primary HPV testing and the impact of vaccination	52
What makes a « good » companion diagnostic in thoracic oncology?	46
Recent updates in the development of molecular assays for the rapid identification and susceptibility testing of MRSA	45
Mild behavioral impairment and neurodegeneration: time for a biomarker-based assessment	44
Evaluating tumor cell- and T cell-derived extracellular vesicles as potential biomarkers of cancer and immune cell competence	41
Cost analyses for malaria molecular diagnosis for research planners in India and beyond	35
Molecular point-of-care testing in the community pharmacy setting: current status and future prospects	34
Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer	33
Alzheimer’s disease: a scoping review of biomarker research and development for effective disease diagnosis	31
Functional proteomic analysis, a missing piece for understanding clonal evolution and cooperation in the tissue microecology	28
Diagnosing thrombophilia: the case for genetic or functional testing?	28
A novel anoikis-related signature predicts prognosis risk and treatment responsiveness in diffuse large B-cell lymphoma	27
Unlocking the power of biomarkers: transforming the diagnosis of acute respiratory distress syndrome	25
Diagnostic approach to leptomeningeal involvement in diffuse large B-cell lymphoma	25
The MALAT1-breast cancer interplay: insights and implications	24
How mitochondrial DNA complicates pre-implantation genetic screening and management	23
Clinical application of noninvasive prenatal testing in twin pregnancies: a single-center experience	23
Genetic risk and gastric cancer: polygenic risk scores in population-based case-control study	23
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease	22
Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma	21
Noncoding RNAs as a potential biomarker for the prognosis of bladder cancer: a systematic review and meta-analysis	21
CRISPR-Cas system: recent advancements in prompt diagnosis of high-risk HPV genotypes in cervical cancer	20
Bacterial extracellular vesicles in biofluids as potential diagnostic biomarkers	20

The promise of liquid biopsies in prostate cancer: a potential point-of-care modality for precision oncology	19
Cell avidity in CAR-T cell therapy	19
Mutation profiling of chronic myeloproliferative neoplasms: improving clinical-molecular prognostic models	19
The clinical importance of high-sensitivity cardiac troponin measurements for risk prediction in non-cardiac surgery	19
Can multiplex molecular panels of microbial pathogens transform respiratory care in critically ill patients?	19
Optimization of time interval for the measurement of plasma lipids for cardiovascular disease risk assessment	18
Molecular diagnostic criteria of myeloproliferative neoplasms	18
Patient outcomes improve when a molecular signature test guides treatment decision-making in rheumatoid arthritis	18
Genomic determinants of biological aggressiveness and poor prognosis of pancreatic cancers: KRAS and beyond	17
Molecular predictors of metastasis in patients with prostate cancer	17
The integration of biomarkers and patient-reported outcomes improves prediction of interstitial cystitis syndrome	17
Point-of-care isothermal nucleic acid amplification tests: progress and bottlenecks for extraction-free sample collection and preparation	17
Comprehensive genomic profiling: a public health system perspective	17
Efficient screening strategies for severe combined immunodeficiencies in newborns	17
The challenges and potential in developing microRNA associated with regeneration as biomarkers to improve prognostication for liver failure syndromes and hepatocellular carcinoma	16
Discovery of potential biomarkers for osteoporosis diagnosis by individual omics and multi-omics technologies	16
LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis	16
Regulation of biomarker analysis: what can be translated in the clinic?	14
Biomarkers of sleep-wake disturbance as predictors of cognitive decline and accelerated disease progression	14
Cytokines as biomarkers of Huntington’s disease progression	14
Urinary biomarkers for immunotherapy response in urothelial carcinoma: current status and future outlook	14
Analytical validation of urine ALCAM ELISA as a test for lupus nephritis	14
Molecular deciphering of melanoma: advances and challenges of neoadjuvant and perioperative treatment	14
Extracellular vesicles as source of biomarkers in hematological malignancies: looking towards clinical applications	13
Association between polymorphisms in TLR3 , TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil	13
Cystic echinococcosis microRNAs as potential noninvasive biomarkers: current insights and upcoming perspective	13
Early diagnostics of fibromyalgia: an overview of the challenges and opportunities	13
Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative disease	13
Guarding the genome: strategies for off-target detection and minimization in CRISPR/Cas9 system	12
Diagnostic approaches for dengue infection	12
Diagnosing, treating and monitoring the inflammatory endotype in osteoarthritis clinical trials	12
Intraoperative detection of axillary metastasis of breast cancer using nucleic acid amplification methods: review of advantages and limitations	12
Association betweenCDH1methylation and esophageal cancer risk: a meta-analysis and bioinformatics study	12
An update on utilising brain natriuretic peptide for risk stratification, monitoring and guiding therapy in heart failure	12
Decoding pancreatic cancer: key risk factors across genetics and lifestyle	12
Lessons from the pandemic: new best practices in selecting molecular diagnostics for point-of-care testing of infectious diseases in sub-Saharan Africa	11
The association between blood sodium levels and survival in patients treated with immune checkpoint inhibitors	11
Unraveling the future: hot topics shaping molecular diagnostics today	11
Genetic-based diagnostics of Parkinson’s disease and other Parkinsonian syndromes	11
Prognostic biomarkers in melanoma: a 2023 update from clinical trials in different therapeutic scenarios	11
The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery	11
MicroRNA dysregulation in schistosomiasis-induced hepatic fibrosis: a systematic review	11
Current and emerging technologies to develop Point-of-Care Diagnostics in medical mycology	10
COVID-19 diagnosis: lessons to learn and hints for preparedness	10
Implications of TERT promoter mutations and telomerase activity in solid tumors with a focus on genitourinary cancers	10
hTERT rs2735940 polymorphism influences lung cancer risk and overall survival in lung cancer patients undergoing platinum-based doublet chemotherapy	10
Potential role of circulating miR-21 in the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis	10
From detection to action: new diagnostic insights into antifungal resistance	10
Advances in pediatric sepsis biomarkers - what have we learnt so far?	9
Potential use of heat shock protein 90 as a biomarker for the diagnosis of human diseases	9

Recent developments in wearable & non-wearable point-of-care biosensors for cortisol detection	9
Association between NUDT17 polymorphisms and breast cancer risk	9
Highlighting and addressing barriers to widespread adaptation of HIV self-testing in the United States	9
Molecular determination of insect venom allergies	9
Development and validation of a nomogram for the prediction of metabolic syndrome in polycystic ovary syndrome in a Chinese population	9
The role of fecal biomarkers in individuals with inflammatory bowel disease	9
Noninvasive prenatal screening in southeast China: clinical application and accuracy evaluation	9
How our molecular understanding of the pathogenesis of Mycobacterium ulcerans infection can improve diagnosis of Buruli ulcer	9
Transforming breast cancer care: the critical role of digital pathology and artificial intelligence in biomarker testing and risk stratification	9
Challenges facing genetic diagnostics of Huntington’s disease: an update	8
Exploring non-sputum biosignatures for tuberculosis triage and diagnosis in children living with HIV	8
Neuroimaging in hereditary spastic paraplegias: from qualitative cues to precision biomarkers	8
Statistical determination of cancer biomarkers: moving forward clinically	8
CD44v6 acts as a directional responding factor in the process of transcoelomic metastasis from gastric carcinoma to Krukenberg tumor	8
Global polymorphism of Plasmodium falciparum histidine rich proteins 2/3 and impact on malaria rapid diagnostic test detection: a systematic review and meta-analysis	8
JC polyomavirus: a short review of its biology, its association with progressive multifocal leukoencephalopathy, and the diagnostic value of different methods to manifest its activity or presence	8
Variants of KLF5 and KLF12 were related to endometrial cancer risk in the Chinese population	8
Cross-sectional risk models using quantitative fecal hemoglobin in colorectal cancer screening: a systematic review	8
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers	7
How reliable are polygenic risk scores for risk prediction in patients with heart disease?	7
The status of standardization in methodologies for tear fluid biomarkers	7
Exploring the prognostic and predictive potential of bacterial biomarkers in non-gastrointestinal solid tumors	7
PCR diagnostic platforms for non- Aspergillus mold infections: ready for routine implementation in the clinic?	7
Loop-mediated isothermal amplification for Candida species surveillance in under-resourced setting: a review of evidence	7
Dual-energy spectral CT in renal cell carcinoma: dawn of a brand-new era?	7
Point-of-care urine tenofovir monitoring of adherence to drive interventions for HIV treatment and prevention	7
Towards improved point-of-care (POC) testing for patients with suspected sepsis: POC tests for host biomarkers and possible microbial pathogens	7
Saliva liquid biopsy for detection of early-stage lesions	7
Diagnostic and predictive value of liquid biopsy-derived exosome miR-21 for breast cancer: a systematic review and meta-analysis	7
Blood-based biomarkers of chronic inflammation	7
TRIB3 overexpression predicts malignant progression and poor prognosis in human solid tumors: bioinformatics validation and clinical significance	7
What are the diagnostic capabilities of glycans for breast cancer?	7
Role of oral microbiome in modulating immune response in oral cancer development. a systematic review	7
Combining oral fluid aMMP-8, calprotectin, and CCAAs in dental panoramic radiography for periodontal disease and systemic disease risk assessment: a point-of-care diagnostic approach	7
Saliva-based Hormone Diagnostics: advances, applications, and future perspectives	7
Validating blood tests as a possible routine diagnostic assay of Alzheimer’s disease	7
Translation of scRNA-seq to a clinical blood test for infection diagnostics	7
Smartphone and wearable diagnostics	7
Liquid biopsy in meningioma: a meta-analysis of diagnostic accuracy across fluid-based biomarkers	7