OOIR: Observatory of International Research

Papers

(The TQCC of Expert Review of Molecular Diagnostics is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)

Article	Citations
Alzheimer’s disease: a scoping review of biomarker research and development for effective disease diagnosis	73
Evaluating tumor cell- and T cell-derived extracellular vesicles as potential biomarkers of cancer and immune cell competence	67
Molecular charcterization of lung adenocarcinoma combining whole exome sequencing, copy number analysis and gene expression profiling	62
Retrospective analysis of the risk factors associated with failure in obtaining effective noninvasive prenatal test results and pregnancy outcomes: a case-control study	54
Mild behavioral impairment and neurodegeneration: time for a biomarker-based assessment	47
Recent updates in the development of molecular assays for the rapid identification and susceptibility testing of MRSA	41
What makes a « good » companion diagnostic in thoracic oncology?	34
Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer	33
Molecular point-of-care testing in the community pharmacy setting: current status and future prospects	31
Evolution and future of cervical cancer screening: from cytology to primary HPV testing and the impact of vaccination	31
Clinicopathological, etiological and molecular characteristics of intrahepatic cholangiocarcinoma subtypes classified by mucin production and immunohistochemical features	29
Analytical validation of a novel multi-target blood-based test to detect hepatocellular carcinoma	27
Polygenic and Network-based studies in risk identification and demystification of cancer	27
Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer	26
Cost analyses for malaria molecular diagnosis for research planners in India and beyond	26
Gene fusions in vascular tumors and their underlying molecular mechanisms	26
Harnessing the potential of genomic characterization of mutational profiles to improve early diagnosis of lung cancer	25
Nuclease activity: an exploitable biomarker in bacterial infections	25
Unlocking the power of biomarkers: transforming the diagnosis of acute respiratory distress syndrome	24
A novel anoikis-related signature predicts prognosis risk and treatment responsiveness in diffuse large B-cell lymphoma	24
Diagnostic approach to leptomeningeal involvement in diffuse large B-cell lymphoma	24
Functional proteomic analysis, a missing piece for understanding clonal evolution and cooperation in the tissue microecology	23
RAD51 as a functional biomarker for homologous recombination deficiency in cancer: a promising addition to the HRD toolbox?	22
The current and future applications of in situ hybridization technologies in anatomical pathology	22
Enzymatic cross-linking of collagens in organ fibrosis – resolution and assessment	21

Long non-coding RNAs and their potential impact on diagnosis, prognosis, and therapy in prostate cancer: racial, ethnic, and geographical considerations	21
The MALAT1-breast cancer interplay: insights and implications	21
Genetic risk and gastric cancer: polygenic risk scores in population-based case-control study	21
Noncoding RNAs as a potential biomarker for the prognosis of bladder cancer: a systematic review and meta-analysis	20
Clinical application of noninvasive prenatal testing in twin pregnancies: a single-center experience	20
Prognostic and survival impact of BCL9 and RPS6KB1 copy number variation detected from circulating free DNA in hepatocellular carcinoma	20
Bacterial extracellular vesicles in biofluids as potential diagnostic biomarkers	19
Emerging concepts in the detection of liver fibrosis in non-alcoholic fatty liver disease	18
Neuroimaging with PET/CT in chronic traumatic encephalopathy: what nuclear medicine can do to move the field forward	18
Early Identification of Fungal and Mycobacterium Infections in Pulmonary Granulomas Using Metagenomic Next-Generation Sequencing on Formalin fixation and paraffin embedding tissue	18
Molecular predictors of metastasis in patients with prostate cancer	17
Efficient screening strategies for severe combined immunodeficiencies in newborns	17
The clinical importance of high-sensitivity cardiac troponin measurements for risk prediction in non-cardiac surgery	17
Predictive biomarkers of response to immune checkpoint inhibitors in hepatocellular carcinoma	17
Discovery of potential biomarkers for osteoporosis diagnosis by individual omics and multi-omics technologies	16
Patient outcomes improve when a molecular signature test guides treatment decision-making in rheumatoid arthritis	16
Comprehensive genomic profiling: a public health system perspective	16
Molecular diagnostic criteria of myeloproliferative neoplasms	16
The integration of biomarkers and patient-reported outcomes improves prediction of interstitial cystitis syndrome	16
LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis	16
Optimization of time interval for the measurement of plasma lipids for cardiovascular disease risk assessment	16
Genomic determinants of biological aggressiveness and poor prognosis of pancreatic cancers: KRAS and beyond	16
Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative disease	14
The challenges and potential in developing microRNA associated with regeneration as biomarkers to improve prognostication for liver failure syndromes and hepatocellular carcinoma	14
Analytical validation of urine ALCAM ELISA as a test for lupus nephritis	14
Point-of-care isothermal nucleic acid amplification tests: progress and bottlenecks for extraction-free sample collection and preparation	14
Early diagnostics of fibromyalgia: an overview of the challenges and opportunities	13
Extracellular vesicles as source of biomarkers in hematological malignancies: looking towards clinical applications	13
Biomarkers of sleep-wake disturbance as predictors of cognitive decline and accelerated disease progression	13
Cytokines as biomarkers of Huntington’s disease progression	13
Association between polymorphisms in TLR3 , TICAM1 and IFNA1 genes and covid-19 severity in Southern Brazil	13
Reviewing the occurrence of large genomic rearrangements in patients with inherited cancer predisposing syndromes: importance of a comprehensive molecular diagnosis	13
Faster infection diagnostics for intensive care unit (ICU) patients	12
Diagnostic approaches for dengue infection	12
Cystic echinococcosis microRNAs as potential noninvasive biomarkers: current insights and upcoming perspective	12
Association betweenCDH1methylation and esophageal cancer risk: a meta-analysis and bioinformatics study	12
Characteristics of circRNA and its approach as diagnostic tool in melanoma	12
An update on utilising brain natriuretic peptide for risk stratification, monitoring and guiding therapy in heart failure	12
Diagnostic salivary biomarkers in oral cancer and oral potentially malignant disorders and their relationships to risk factors – A systematic review	12
Lessons from the pandemic: new best practices in selecting molecular diagnostics for point-of-care testing of infectious diseases in sub-Saharan Africa	12
The role of molecular heterogeneity targeting resistance mechanisms to lung cancer therapies	12
Intraoperative detection of axillary metastasis of breast cancer using nucleic acid amplification methods: review of advantages and limitations	11
Application of selected biosensor techniques in clinical diagnostics	11
Mortality prediction of patients with spontaneous intracerebral hemorrhage by serum soluble Fas ligand concentrations	11
Genetic-based diagnostics of Parkinson’s disease and other Parkinsonian syndromes	11
Unraveling the future: hot topics shaping molecular diagnostics today	11
The dark side of lipid metabolism in prostate and renal carcinoma: novel insights into molecular diagnostic and biomarker discovery	11
The association between blood sodium levels and survival in patients treated with immune checkpoint inhibitors	11
Decoding pancreatic cancer: key risk factors across genetics and lifestyle	11
Clinicopathologic and prognostic roles of circular RNA plasmacytoma variant translocation 1 in various cancers	11

Prognostic biomarkers in melanoma: a 2023 update from clinical trials in different therapeutic scenarios	11
Quantitative versus qualitative estrogen and luteinizing hormone testing for personal fertility monitoring	11
An updated review of the role of lncRNAs and their contribution in various molecular subtypes of breast cancer	11
From detection to action: new diagnostic insights into antifungal resistance	10
Association between NUDT17 polymorphisms and breast cancer risk	10
Recent developments in wearable & non-wearable point-of-care biosensors for cortisol detection	10
hTERT rs2735940 polymorphism influences lung cancer risk and overall survival in lung cancer patients undergoing platinum-based doublet chemotherapy	10
Current and emerging technologies to develop Point-of-Care Diagnostics in medical mycology	10
Noninvasive prenatal screening in southeast China: clinical application and accuracy evaluation	10
MicroRNA dysregulation in schistosomiasis-induced hepatic fibrosis: a systematic review	10
COVID-19 diagnosis: lessons to learn and hints for preparedness	10
Implications of TERT promoter mutations and telomerase activity in solid tumors with a focus on genitourinary cancers	10
Potential role of circulating miR-21 in the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis	10
The role of fecal biomarkers in individuals with inflammatory bowel disease	10
Known biomarkers for monitoring pregnancy complications	9
Neuroimaging in hereditary spastic paraplegias: from qualitative cues to precision biomarkers	9
Advances in pediatric sepsis biomarkers - what have we learnt so far?	9
Potential use of heat shock protein 90 as a biomarker for the diagnosis of human diseases	9
Highlighting and addressing barriers to widespread adaptation of HIV self-testing in the United States	9
JC polyomavirus: a short review of its biology, its association with progressive multifocal leukoencephalopathy, and the diagnostic value of different methods to manifest its activity or presence	9
Molecular determination of insect venom allergies	9
How our molecular understanding of the pathogenesis of Mycobacterium ulcerans infection can improve diagnosis of Buruli ulcer	9
Statistical determination of cancer biomarkers: moving forward clinically	8
Towards improved point-of-care (POC) testing for patients with suspected sepsis: POC tests for host biomarkers and possible microbial pathogens	8
Determining the accuracy of next generation sequencing based copy number variation analysis in Hereditary Breast and Ovarian Cancer	8
Future potential of metagenomics in microbiology laboratories	8
Validating blood tests as a possible routine diagnostic assay of Alzheimer’s disease	8
Variants of KLF5 and KLF12 were related to endometrial cancer risk in the Chinese population	8
How reliable are polygenic risk scores for risk prediction in patients with heart disease?	8
Saliva-based Hormone Diagnostics: advances, applications, and future perspectives	8
What are the diagnostic capabilities of glycans for breast cancer?	8
Cross-sectional risk models using quantitative fecal hemoglobin in colorectal cancer screening: a systematic review	8
CD44v6 acts as a directional responding factor in the process of transcoelomic metastasis from gastric carcinoma to Krukenberg tumor	8
Point-of-care urine tenofovir monitoring of adherence to drive interventions for HIV treatment and prevention	8
Global polymorphism of Plasmodium falciparum histidine rich proteins 2/3 and impact on malaria rapid diagnostic test detection: a systematic review and meta-analysis	8
One biomarker does not fit all: tailoring anti-infective therapy through utilization of procalcitonin and other specific biomarkers	8
Dual-energy spectral CT in renal cell carcinoma: dawn of a brand-new era?	8