OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Immunology is 25. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Regulation goes awry in the liver	1047
Heart failure affects innate immune memory	991
Natural killer cells that target autoimmune cells linked with protection against multiple sclerosis	848
Early life antibiotics have lasting effects on the lung epithelium	848
Exercise induces metabolic changes in the gut microbiota that enhance anti-tumour T cell responses	762
Vaccines only partially protect against Long COVID	527
Decoding the human prenatal immune system with single-cell multi-omics	495
Muscle spindle macrophages regulate motor coordination	430
BCG plus β-glucan trains neutrophils to beat bladder cancer	416
Albumin protects against deadly fungal infection	399
Author Correction: Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies	367
Metabolite and nutrient regulation of macrophages in obesity and metabolic disease	366
Human immune organoids: a tool to study vaccine responses	353
Shaping neutrophil morphology and function: the importance of a segmented nucleus	334
The danger theory of immunity revisited	332
Regulation of cGAS–STING signalling and its diversity of cellular outcomes	328
The immunology of asthma and chronic rhinosinusitis	321
Viral infection and antiviral immunity in the oral cavity	320
Challenges in developing personalized neoantigen cancer vaccines	318
Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses	312
Omicron alone provides limited cross-protection	309
Gut commensals promote antiviral immunity via extracellular vesicles	307
Targeting malaria transmission	294
The distinctive immune features of long COVID	287
Novel insights into the immune response to bacterial T cell superantigens	287

Human T follicular regulatory cells with helper and regulatory lineage origins	268
Fatty liver disease induced by maternal obesity is driven by metabolic rewiring of Kupffer cells	257
Neutrophils are dispensable for Shigella control: macrophages take centre stage	242
Stressed tumours release immunosuppressive vesicles	238
Encouraging vaccine uptake: lessons from behavioural science	231
Mechanistic insights from inflammasome structures	228
A guide to adaptive immune memory	228
Antiviral neutralizing antibodies: from in vitro to in vivo activity	223
The NLR gene family: from discovery to present day	222
How bile acids and the microbiota interact to shape host immunity	210
Mapping the developmental trajectory and recruitment of memory-phenotype Ly49+CD8+ T cells	205
Blood neutrophil subset predicts the success of immune checkpoint inhibitors in cancer	192
Adaptive meets innate: CD8+ T cells kill MHC-I-negative tumour cells	189
You are what you ate: myeloid cells trained by fatty acids	189
T cell–eosinophil collaboration	182
Gut ILC2s remember IL-25	176
The kiss a cell can’t forget: tracking cell–cell interactions with uLIPSTIC	170
Online immunology education for a global world	168
Salt sensitivity includes effects on immune cell signalling and metabolism	163
Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease	160
The OrganiX microfluidic system to recreate the complex tumour microenvironment	160
Splenic stromal niches in homeostasis and immunity	159
The cancer-immune dialogue in the context of stress	159
JAKs drive innate-like TH9 cell activation in allergy	154
Feeding IgA+ plasma cells	154
Negative regulation of fungal immunity by STING	153
Mechanistic insights into Long COVID in hamsters	149
Spatial resolution of host–microbiome interactions	147
Low risk of CAR T cells going rogue	140
An ILC3-intrinsic, CTLA4-dependent intestinal checkpoint	135
Monocytes rule energy metabolism with an iron fist	131
Bacteria in tumours promote cancer progression	118
Author Correction: Cancer cell metabolism and antitumour immunity	118
The immunopathogenesis of narcolepsy type 1	117
Neutrophils make matrix to fortify barrier immunity	113
The spatial and temporal activation of macrophages during fibrosis	113
Microenvironmental regulation of solid tumour resistance to CAR T cell therapy	113
Monkeypox: disease epidemiology, host immunity and clinical interventions	112
Olfactory immunology: the missing piece in airway and CNS defence	111
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies	110
The biology of TREM receptors	107
Commensal fungi support granulocyte development	106
Rejuvenation through checkpoint inhibitors?	106
T cells target viral protein to remove senescent fibroblasts	105
Publisher Correction: Immunological studies in trans-individuals undergoing gender affirming hormone therapy	105
mRNA vaccine for treating pancreatic cancer	96
We need to keep an eye on avian influenza	94
Cytokine multimerization: when more is more and sometimes less	93
Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers	89
Early life allergen sensitivity starts in the skin	88

Spatial immunometabolic zonation in tuberculosis granulomas	83
Podoplanin mediates stromal–immune crosstalk in the lymph node	80
Guardians of immune privilege	76
Germinal centre IL-4 enforces tissue confinement of IgE memory	75
MR1 antigen presentation to MAIT cells and other MR1-restricted T cells	73
The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases	70
Local immune recognition of trophoblast in early human pregnancy: controversies and questions	69
DNA damage and repair in age-related inflammation	68
Glomerulonephritis: immunopathogenesis and immunotherapy	68
The promise of immunotherapy for central nervous system tumours	66
Bacterial serotonin induces Treg cells in neonates	65
Pollution impairs lung defences with age	65
Neutralizing autoantibodies against type 1 interferons identified in West Nile virus encephalitis	61
Boosting cytotoxic T cells for immunotherapy	61
Early antiviral type I interferon impairs lung metastasis	60
Lung-resident memory B cells class-switch to IgE	56
Actin branching maintains tissue-resident mast cells	56
Asymptomatic SARS-CoV-2 linked to HLA-B*15:01	55
Microbiota licenses protective CD8+ T cell responses against neonatal influenza	55
Hypoxia and IL-24 drive a sterile wound healing pathway	52
Insights into immune cell–fibroblast communication in heart disease	51
Turning on anti-tumour T cells via MTAP	51
CODEX multiplexed tissue imaging	50
Defining myeloid-derived suppressor cells	49
IL-17 and IL-17-producing cells in protection versus pathology	48
The renaissance of oral tolerance: merging tradition and new insights	48
Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection	48
Integrated organ immunity: a path to a universal vaccine	48
The autoinflammatory disease APLAID is driven by G-CSF	47
When ‘mild’ COVID-19 is not so mild	47
Effect of prenatal stress on the developing brain	47
PerturbView: scalable image-based perturbation screens in cells and tissues	46
Bacteria tag tumours for CAR T cell attack	46
Author Correction: The immunology of long COVID	45
Disturbance of cytoskeleton primes RIG-I-like receptors	45
Boosting glymphatic drainage via adrenergic receptor inhibition protects the injured brain	45
NK cell mechanosensing through CD16a	44
Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies	44
Immunology of food aversion	42
Mitochondria in monocyte-derived cells promote tissue damage in multiple sclerosis	42
NMDAR-directed CAAR T cells show promise for autoimmune encephalitis	41
Harnessing mucosal immunity for protective vaccines	41
The ageing immune system as a driver of systemic ageing	37
The role of transcription factors in shaping regulatory T cell identity	37
Role of thymic stromal lymphopoietin in allergy and beyond	36
Understanding COVID-19-associated coagulopathy	35
The role of galectins in immunity and infection	35
CARD8 kills CD4+ T cells in response to HIV entry	33
Transposon-derived decoy fine-tunes IFN responses	33
Inhibition of NR4A1 potentiates a CD8+ T cell response against active tuberculosis	33
Targeting ER stress sensor restores immunogenicity of chemotherapy	33
Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors	32
Author Correction: The role of platelets in immune-mediated inflammatory diseases	32
Macrophages bordering the brain parenchyma regulate the flow of cerebrospinal fluid	31
Contextualizing TH17 cells in cancer	30
Metabolites as signalling molecules in the tumour immune microenvironment	30
CRISPR screens for functional interrogation of immunity	28
The diversity of CD8+ T cell dysfunction in cancer and viral infection	28
Macrophage quality control of HSCs	27
Regulation of innate-like activities of neonatal CD8+ T cells	27
Unconventional T cells shape tissue-specific lymph node responses	26
Focusing on the correct gene signatures for SLE	26
Human ILC2s can act as cytolytic killers	26
Obesity-associated autoreactivity	26
Fetal Treg cell reprogramming links maternal immunity to neurodevelopment	25
Type I interferon at the crossroads of metastatic dissemination	25
Signal length not strength guides T cell fate	25
Osteoblast-derived ATP maintains bone marrow plasma cells	25
Publisher Correction: Inflammasome components as new therapeutic targets in inflammatory disease	25