Nature Reviews Cancer

Article	Citations
Computing brain metastasis impact	1665
Digging for treasures in the tumour interactome	1205
An inhospitable site	999
Fructose takes a detour to feed cancer	624
Implementing practice-changing progress for managing cancer of unknown primary	583
Exploiting metabolic cell death for cancer therapy	565
Oncofetal reprogramming in tumour development and progression	388
INVADEseq to study the intratumoural microbiota at host single-cell resolution	387
Emerging strategies to investigate the biology of early cancer	377
Combining spatial transcriptomics and AI to enhance brain tumour diagnosis	362
Combinatorial strategies to target RAS-driven cancers	353
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment	331
How medical anthropology can contribute to cancer research	325
Mapping the prostate cell family tree	323
Fighting cancer with fat	317
Reply to ‘Heterogeneity of TP53 mutations necessitates differentiation with p53-rescue therapies’	286
3D chromatin architecture as a predictor of somatic mutations in cancer genomes	281
Author Correction: Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma	263
Connie J. Eaves (1944–2024)	259
Antihistamines boost immunotherapy	251
The evolution of cancer and ageing: a history of constraint	235
The role of CRAF in cancer progression: from molecular mechanisms to precision therapies	227
The recruitment of metastasis-associated monocytes	215
Translating premalignant biology to accelerate non-small-cell lung cancer interception	208
Context-dependent functions of pattern recognition receptors in cancer	205

Epithelial and stromal co-evolution and complicity in pancreatic cancer	204
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel	201
Gut microbes produce novel genotoxic metabolites	197
Tertiary lymphoid structures as hubs of antitumour immunity	197
No mutation, tumour initiation	195
Nanoreceptors take down mutant p53	192
Impersonating neurons	187
Dendritic cells rise and shine	186
Tumour EVPs disrupt liver function	182
AACR 2025	173
Measuring HLA disruption using MHC Hammer	167
Persistence is key	166
Thelpers? More like Ttroublemakers	160
Removing barriers to address sex differences in anticancer drug toxicity	158
Remodelling of the tumour microenvironment by the kallikrein-related peptidases	156
Moonlighting functions of glucose metabolic enzymes and metabolites in cancer	149
Defining a ‘cells to society’ research framework for appendiceal tumours	146
3D bioprinted cancer models: from basic biology to drug development	140
How chemokines organize the tumour microenvironment	136
Natural killer cells in antitumour adoptive cell immunotherapy	130
Bone voyage: immune crosstalk sets sail	128
B-ring sterols to the rescue	126
In-depth organoid profiling of pancreatic cancer	123
Visualizing intratumoural heterogeneity with EpicMIBI	122
Identifying spatial cellular structures with SPACE-GM	120
The path to leptomeningeal metastasis	117
Points of entry for tumour-infiltrating lymphocytes	116
Environmental endocrine disruptors: rethinking the origins of early-onset ER+ breast cancer	115
Regulatory T cells in the tumour microenvironment	115
Un-Fair Skin: racial disparities in acral melanoma research	112
The immune microenvironment of colorectal cancer	112
Metabolic interplays between the tumour and the host shape the tumour macroenvironment	108
Dynamics and specificities of T cells in cancer immunotherapy	107
Leveraging the replication stress response to optimize cancer therapy	107
Linking cell mechanical memory and cancer metastasis	103
In situ decellularization of tissues to resolve the tumour-associated matrix	100
Understanding and addressing race disparities in childhood cancer outcomes	97
Race influences the tumour microbiome	97
Encoding spatial tumour dynamics with Starfysh	97
Deciphering the cancer genome and epigenome	96
The link between vitamin D and prostate cancer	91
Taming TAMs in brain metastases	89
Don’t blame the messenger: lessons learned for cancer mRNA vaccines during the COVID-19 pandemic	88
Cancer nanomedicine	84
Polygenic scores in cancer	83
Acetyl-CoA metabolism in cancer	82
RNA splicing dysregulation and the hallmarks of cancer	82
Targeted protein degradation for cancer therapy	81
Z-nucleic acids give immunotherapy a boost	78
Local CAR manufacturing	75

Parity modulates epithelial–immune cell communication	72
Author Correction: Antibody-based proteomics: fast-tracking molecular diagnostics in oncology	69
Right ON target: a new RAS-GTP inhibitor	69
Prime editing GEMMs to model cancer mutations	67
Integrative medicine in oncology: redefining the standard of care	66
Expanding the utility of precision oncology knowledge bases	65
NOTUM-mediated stem cell competition in CRC	64
A trojan horse to target spliceosome mutant cells	62
Tamoxifen takes the wheel	62
Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities	59
Defining precancer: a grand challenge for the cancer community	59
Tertiary lymphoid structures in anticancer immunity	54
Chromothripsis in cancer	51
Targeting ferroptosis as a vulnerability in cancer	49
Neutrophils: a roadblock for immunotherapy	47
Revealing genomic secrets of archival FFPE samples	47
In vivo labelling system to study cell neighbourhoods	47
Judith Campisi (1948–2024)	45
Quantum probes in cancer research	45
Functional lineage tracing to study the clonal evolution of therapy resistance	43
New pathogen on the block	42
Inferring cancer metabolism from gene-expression data	41
Glycogen condensates drive tumorigenesis by trapping Hippo kinases	40
Immune-checkpoint inhibitor-mediated myocarditis: CTLA4, PD1 and LAG3 in the heart	38
Recent advances in therapeutic cancer vaccines	38
The present and future of the Cancer Dependency Map	37
Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data	36
Carcinogenesis at single-cell resolution	35
Bidirectional CART.BiTE cells bring new hope	34
Patient-derived organoids unveil sarcoma vulnerabilities	34
Global post-mortem tissue donation programmes to accelerate cancer research	33
Transfer RNAs as dynamic and critical regulators of cancer progression	31
Focusing on the complex and dynamic interplay between ageing and cancer	31
A timeline of tumour-associated macrophage biology	30
Developing dietary interventions as therapy for cancer	30
Epigenomic heterogeneity as a source of tumour evolution	30
Traject3d for studying 3D cellular heterogeneity	29
Digitally enhanced Raman spectroscopy	29
Author Correction: Integrative medicine in oncology: redefining the standard of care	29
Mechanisms and treatment of cancer therapy-induced peripheral and central neurotoxicity	28
We cannot ignore the cancer risks of wildfires	27
Harnessing the influenza virus to fight cancer	26
Structural variations in cancer and the 3D genome	26
Neuro-immune cross-talk in cancer	25
Mechanisms, challenges and opportunities for FLASH radiotherapy in cancer	24
Guardrails for the use of generalist AI in cancer care	23
Fcγ receptors and immunomodulatory antibodies in cancer	22
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity	21
Targeting cancer cell dormancy	21
The role of ROS in tumour development and progression	20
mRNA-based cancer therapeutics	19
Frozen silicified vaccines	18
Next-generation epidemiologic cohorts for cancer aetiology	18
AACR 2024	18
Fungi in cancer: not such a ‘fun-guy’	17
Male melanoma comes of age	17
The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment	17
Ethnically diverse cancer cell lines for drug testing	17
Modelling and deciphering tumour metabolism in CRISPR screens	17
CAFs promote CRPC	16
Decoding the functional impact of the cancer genome through protein–protein interactions	15
Advances in cutaneous squamous cell carcinoma	14
Mechanisms driving the immunoregulatory function of cancer cells	14
EMT in chemoresistance	14
Silent mutations make noise	13
Energizing leukaemia	13
Author Correction: Learning to distinguish progressive and non-progressive ductal carcinoma in situ	13
Multiomics-guided cellular immunotherapies	12
Same same but different	11
Inflammatory neutrophils	10
Disconnecting multicellular networks in brain tumours	10
Key role for microbiota in gut–bone crosstalk	10
Deep tissue imaging of cancer in the infrared	10
Stemness in solid malignancies: coping with immune attack	10
Decoding the basis of histological variation in human cancer	10
Advances in translational research of the rare cancer type adrenocortical carcinoma	9
Exploiting senescence for the treatment of cancer	9
Therapeutic resistance to anti-oestrogen therapy in breast cancer	9
Air pollution promotes tumorigenesis through pre-existing oncogenic mutations	8
Addressing the gaps in cancer screening for LGBTQ+ individuals	8

Glioblastomas remodel neural circuits	8
Mapping out mitochondria	8
Enhanced transposable elements	8
Too much of a good thing	8
Pathogenesis of cancers derived from thyroid follicular cells	7
Androgen receptor activation for breast cancer therapy	7
Fungi in cancer	7
Black voices in cancer research and oncology	7
Targeting sex steroid biosynthesis for breast and prostate cancer therapy	7
Limiting bias in AI models for improved and equitable cancer care	6
Overcoming heterogeneity with 3D whole-tumour sampling	6
Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment	6
Big data in basic and translational cancer research	5
Feeding latent brain metastasis	5
Conventional chemotherapy: millions of cures, unresolved therapeutic index	5
Nucleotide metabolism: a pan-cancer metabolic dependency	5
Breast milk for breast cancer detection	5
Tumour avatars to model patients’ responses to immunotherapy	5
Hubs of transcriptional activity	5
Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection	5
Proximity labelling to study chromatin interactomes	5
Aristolochic acid-associated cancers: a public health risk in need of global action	5
The fibroinflammatory response in cancer	5
Obesity as a promoter in BRCA mutation carriers	4
Defining and using immune archetypes to classify and treat cancer	4
Epigenetic memory	4
Replication timings affect the frequency of chromosomal translocation	4
Modelling the ageing dependence of cancer evolutionary trajectories	4
Understanding tumour endothelial cell heterogeneity and function from single-cell omics	4
Small speckles, big impact	4
Targeting the roots of myeloid malignancies with T cell receptors	4
Intercepting gastric cancer	4
Polyamines in cancer: integrating organismal metabolism and antitumour immunity	4
VIBRANT: mapping cell phenotypes using vibrational spectroscopy	4
Protection against tumour formation	4
The dynamic role of platelets in cancer progression and their therapeutic implications	3
Studying extrachromosomal DNA with the ecTag method	3
Tracing the evolutionary history of breast cancer	3
Exploiting temporal aspects of cancer immunotherapy	3
Lactate gives a sour taste	3
scAtlasVAE: a deep learning framework for generating a human CD8+ T cell atlas	3
Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma	3
Lymphatic vessels in the age of cancer immunotherapy	3
Multiplex protein imaging in tumour biology	3
Enhancing cellular immunotherapies in cancer by engineering selective therapeutic resistance	3
A machine learning toolkit for subtyping cancer in existing and new datasets	3
Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications	3
Epigenetic lesions drive gliomagenesis	2
Naughty neutrophils	2
Challenging the status quo to improve the translational potential of preclinical oncology studies	2
Tumour-derived d-2HG blocks T cell cytotoxicity	2
Identification, functional insights and therapeutic targeting of EMT tumour states	2
Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer	2
Author Correction: The importance of 3D fibre architecture in cancer and implications for biomaterial model design	2
Shared immunosuppressive mechanism between pregnancy and cancer	2
Preprints as tools to advance careers	2
Targeting aberrant splicing	2
NET-working under stress	2
Cancer’s sensory experience	2
Hidden epithelial subtypes refine colorectal cancer classification	2
Ageing lipids map melanoma’s journey	2
Presenting fibroblasts	2
Mastering the use of cellular barcoding to explore cancer heterogeneity	2
Tryptophan metabolite improves PDAC response rates and survival	2
Tracking genome evolution following p53 inactivation	2
Tumour hypoxia in driving genomic instability and tumour evolution	2
Aggregating premalignancy	2
Nanotherapy: targeting the tumour microenvironment	2
Advancing cancer research via comparative oncology	2
Managing cancer following the World Trade Center disaster	2
Pressing defence	2
Taking a detour	2
Gender and sex interactions are intrinsic components of cancer phenotypes	2
PDX models for functional precision oncology and discovery science	2
Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention	2
Heard immunity in CAR T cells	2
How protons pave the way to aggressive cancers	2
Salmonella, the insidious contributor to gallbladder and colon cancers	2
How cancer reduces motivation	2
Activated neutrophils: the anti-hero	2
CRISPR in cancer biology and therapy	2
Rusting away with age	2
Targeting the tumour’s little helpers	2
Oncologists must act to manage cancer detected through prenatal screening	2
Liquid biopsies for Hodgkin lymphoma	2
Allies in the epidermis	2
Expanding oesophageal cancer research and care in eastern Africa	2
Stromal cells drive tumorigenesis in BRCA1 mutation carriers	2
Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities	2
Sex affects cancer genomes	2