Nature Reviews Cancer

Article	Citations
Linking pancreatic renewal and cancer initiation	1473
Computing brain metastasis impact	1233
Digging for treasures in the tumour interactome	1045
INVADEseq to study the intratumoural microbiota at host single-cell resolution	886
An inhospitable site	541
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment	507
Fructose takes a detour to feed cancer	471
Combinatorial strategies to target RAS-driven cancers	397
Artificial intelligence in cancer research, diagnosis and therapy	347
Emerging strategies to investigate the biology of early cancer	337
Oncofetal reprogramming in tumour development and progression	336
Mapping the prostate cell family tree	318
How medical anthropology can contribute to cancer research	290
Author Correction: Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma	288
Connie J. Eaves (1944–2024)	281
The recruitment of metastasis-associated monocytes	278
Antihistamines boost immunotherapy	266
Fighting cancer with fat	262
The role of CRAF in cancer progression: from molecular mechanisms to precision therapies	256
Tertiary lymphoid structures as hubs of antitumour immunity	250
Reply to ‘Heterogeneity of TP53 mutations necessitates differentiation with p53-rescue therapies’	242
Targeting transcription cycles in cancer	238
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel	229
Translating premalignant biology to accelerate non-small-cell lung cancer interception	225
Context-dependent functions of pattern recognition receptors in cancer	220

Epithelial and stromal co-evolution and complicity in pancreatic cancer	211
No mutation, tumour initiation	207
Impersonating neurons	206
Under pressure	204
Nanoreceptors take down mutant p53	202
Defining a ‘cells to society’ research framework for appendiceal tumours	192
Gut microbes produce novel genotoxic metabolites	179
Tumour EVPs disrupt liver function	176
Removing barriers to address sex differences in anticancer drug toxicity	169
Dendritic cells rise and shine	169
Persistence is key	167
Thelpers? More like Ttroublemakers	166
Moonlighting functions of glucose metabolic enzymes and metabolites in cancer	165
How chemokines organize the tumour microenvironment	165
AACR 2025	160
Measuring HLA disruption using MHC Hammer	158
Tumour–host interactions through the lens of Drosophila	156
Remodelling of the tumour microenvironment by the kallikrein-related peptidases	150
3D bioprinted cancer models: from basic biology to drug development	147
Natural killer cells in antitumour adoptive cell immunotherapy	147
Points of entry for tumour-infiltrating lymphocytes	146
B-ring sterols to the rescue	144
Bone voyage: immune crosstalk sets sail	139
In-depth organoid profiling of pancreatic cancer	138
Identifying spatial cellular structures with SPACE-GM	138
Visualizing intratumoural heterogeneity with EpicMIBI	137
Un-Fair Skin: racial disparities in acral melanoma research	133
The plasticity of mRNA translation during cancer progression and therapy resistance	131
Linking cell mechanical memory and cancer metastasis	120
The path to leptomeningeal metastasis	119
Metabolic interplays between the tumour and the host shape the tumour macroenvironment	118
Leveraging the replication stress response to optimize cancer therapy	115
Regulatory T cells in the tumour microenvironment	108
In situ decellularization of tissues to resolve the tumour-associated matrix	104
Dynamics and specificities of T cells in cancer immunotherapy	104
Deciphering the cancer genome and epigenome	100
Understanding and addressing race disparities in childhood cancer outcomes	100
Encoding spatial tumour dynamics with Starfysh	93
Taming TAMs in brain metastases	91
The link between vitamin D and prostate cancer	89
Race influences the tumour microbiome	89
Don’t blame the messenger: lessons learned for cancer mRNA vaccines during the COVID-19 pandemic	89
Polygenic scores in cancer	88
Cancer nanomedicine	87
Targeted protein degradation for cancer therapy	87
Acetyl-CoA metabolism in cancer	87
RNA splicing dysregulation and the hallmarks of cancer	86
Z-nucleic acids give immunotherapy a boost	84
Local CAR manufacturing	84
Author Correction: Antibody-based proteomics: fast-tracking molecular diagnostics in oncology	83

Parity modulates epithelial–immune cell communication	82
Right ON target: a new RAS-GTP inhibitor	82
Prime editing GEMMs to model cancer mutations	79
A trojan horse to target spliceosome mutant cells	79
Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities	78
Expanding the utility of precision oncology knowledge bases	78
Integrative medicine in oncology: redefining the standard of care	77
Defining precancer: a grand challenge for the cancer community	76
NOTUM-mediated stem cell competition in CRC	75
Chromothripsis in cancer	75
Targeting ferroptosis as a vulnerability in cancer	71
Tertiary lymphoid structures in anticancer immunity	71
Starting a new job	68
Glycogen condensates drive tumorigenesis by trapping Hippo kinases	67
Quantum probes in cancer research	65
Functional lineage tracing to study the clonal evolution of therapy resistance	64
Neutrophils: a roadblock for immunotherapy	61
Revealing genomic secrets of archival FFPE samples	59
In vivo labelling system to study cell neighbourhoods	59
New pathogen on the block	58
Judith Campisi (1948–2024)	58
Recent advances in therapeutic cancer vaccines	56
Inferring cancer metabolism from gene-expression data	56
The present and future of the Cancer Dependency Map	55
Immune-checkpoint inhibitor-mediated myocarditis: CTLA4, PD1 and LAG3 in the heart	53
Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data	52
Cell states can give tumorigenesis a head start	46
Carcinogenesis at single-cell resolution	46
Microbiota links to immunotherapy toxicity	45
Bidirectional CART.BiTE cells bring new hope	44
Patient-derived organoids unveil sarcoma vulnerabilities	43
Epigenomic heterogeneity as a source of tumour evolution	43
Global post-mortem tissue donation programmes to accelerate cancer research	41
Transfer RNAs as dynamic and critical regulators of cancer progression	39
Evolution and progression of Barrett’s oesophagus to oesophageal cancer	38
A timeline of tumour-associated macrophage biology	38
Developing dietary interventions as therapy for cancer	38
Traject3d for studying 3D cellular heterogeneity	35
Author Correction: Integrative medicine in oncology: redefining the standard of care	33
We cannot ignore the cancer risks of wildfires	32
Neuro-immune cross-talk in cancer	32
Guardrails for the use of generalist AI in cancer care	31
Tissue clearing to examine tumour complexity in three dimensions	30
Harnessing the influenza virus to fight cancer	30
Digitally enhanced Raman spectroscopy	29
mRNA-based cancer therapeutics	28
Fcγ receptors and immunomodulatory antibodies in cancer	25
Targeting cancer cell dormancy	25
The immunological and metabolic landscape in primary and metastatic liver cancer	24
Structural variations in cancer and the 3D genome	24
The role of ROS in tumour development and progression	23
Integrating microbiomics in cancer management	23
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity	23
AACR 2024	22
Frozen silicified vaccines	22
CAFs promote CRPC	21
Ethnically diverse cancer cell lines for drug testing	19
Decoding the functional impact of the cancer genome through protein–protein interactions	18
Next-generation epidemiologic cohorts for cancer aetiology	17
Male melanoma comes of age	17
The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment	16
EMT in chemoresistance	16
Modelling and deciphering tumour metabolism in CRISPR screens	16
Mechanisms driving the immunoregulatory function of cancer cells	15
Fungi in cancer: not such a ‘fun-guy’	15
Key role for microbiota in gut–bone crosstalk	14
Advances in cutaneous squamous cell carcinoma	14
Inflammatory neutrophils	14
Silent mutations make noise	14
Disconnecting multicellular networks in brain tumours	13
Stabilizing the mood of tumours	13
Author Correction: Learning to distinguish progressive and non-progressive ductal carcinoma in situ	13
Decoding the basis of histological variation in human cancer	13
Multiomics-guided cellular immunotherapies	12
Deep tissue imaging of cancer in the infrared	12
Advances in translational research of the rare cancer type adrenocortical carcinoma	12
Stemness in solid malignancies: coping with immune attack	11
Energizing leukaemia	11
Exploiting senescence for the treatment of cancer	11
Glioblastomas remodel neural circuits	10

Therapeutic resistance to anti-oestrogen therapy in breast cancer	10
Air pollution promotes tumorigenesis through pre-existing oncogenic mutations	10
Enhanced transposable elements	10
Mapping out mitochondria	9
Black voices in cancer research and oncology	8
Too much of a good thing	8
Addressing the gaps in cancer screening for LGBTQ+ individuals	8
Androgen receptor activation for breast cancer therapy	8
Overcoming heterogeneity with 3D whole-tumour sampling	7
Aristolochic acid-associated cancers: a public health risk in need of global action	7
Fungi in cancer	7
Limiting bias in AI models for improved and equitable cancer care	7
Big data in basic and translational cancer research	6
Pathogenesis of cancers derived from thyroid follicular cells	6
Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection	6
Nucleotide metabolism: a pan-cancer metabolic dependency	5
Targeting sex steroid biosynthesis for breast and prostate cancer therapy	5
Breast milk for breast cancer detection	5
Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment	5
Proximity labelling to study chromatin interactomes	5
Polyamines in cancer: integrating organismal metabolism and antitumour immunity	4
Feeding latent brain metastasis	4
Intercepting gastric cancer	4
The fibroinflammatory response in cancer	4
Metabolic mechanisms of medulloblastoma metastasis	4
Hubs of transcriptional activity	4
Defining and using immune archetypes to classify and treat cancer	4
Understanding tumour endothelial cell heterogeneity and function from single-cell omics	4
Epigenetic memory	4
Conventional chemotherapy: millions of cures, unresolved therapeutic index	4
Tumour avatars to model patients’ responses to immunotherapy	4
Obesity as a promoter in BRCA mutation carriers	4
Small speckles, big impact	4
scAtlasVAE: a deep learning framework for generating a human CD8+ T cell atlas	3
Lymphatic vessels in the age of cancer immunotherapy	3
Exploiting temporal aspects of cancer immunotherapy	3
Towards cancer equity via patient outreach	3
Studying extrachromosomal DNA with the ecTag method	3
Multiplex protein imaging in tumour biology	3
Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma	3
Tracing the evolutionary history of breast cancer	3
Protection against tumour formation	3
A machine learning toolkit for subtyping cancer in existing and new datasets	3
Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment	3
Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications	3
VIBRANT: mapping cell phenotypes using vibrational spectroscopy	3
Ageing lipids map melanoma’s journey	2
The dynamic role of platelets in cancer progression and their therapeutic implications	2
Taking the path of most resistance	2
Hidden epithelial subtypes refine colorectal cancer classification	2
Oncologists must act to manage cancer detected through prenatal screening	2
The BMP pathway could curb cachexia	2
Epigenetic lesions drive gliomagenesis	2
Expanding oesophageal cancer research and care in eastern Africa	2
Non-coding driver mutations in human cancer	2
Cancer’s sensory experience	2
Heard immunity in CAR T cells	2
Harnessing multimodal data integration to advance precision oncology	2
Sex affects cancer genomes	2
Enhancing cellular immunotherapies in cancer by engineering selective therapeutic resistance	2
Presenting fibroblasts	2
Stromal cells drive tumorigenesis in BRCA1 mutation carriers	2
Targeting the tumour’s little helpers	2
Author Correction: The importance of 3D fibre architecture in cancer and implications for biomaterial model design	2
Advancing cancer research via comparative oncology	2
Targeting aberrant splicing	2
PDX models for functional precision oncology and discovery science	2
Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities	2
Lactate gives a sour taste	2
Bringing community to our pages	2
Targeting the DNA damage response in immuno-oncology: developments and opportunities	2
In Polϴ position	2
Naughty neutrophils	2
How protons pave the way to aggressive cancers	2
Rusting away with age	2
Mastering the use of cellular barcoding to explore cancer heterogeneity	2
Taking a detour	2
Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention	2
The rhythm of the night	1
Cholesterol-fuelled glioblastoma	1
CAF-induced physical constraints controlling T cell state and localization in solid tumours	1
Publisher Correction: Programmed death ligand 1 signals in cancer cells	1
Characterization of the B cell receptor repertoire in melanoma	1
Revisiting the TGFβ paradox: insights from HPV-driven cancer and the DNA damage response	1
Gasdermin E shields PDAC	1
Reflecting on 20 years of progress	1
Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities	1
Programming immune escape	1
Approaching cancer during pregnancy	1
Switching on cancer survival mechanisms	1
Lifestyle interventions for cancer survivors	1
Extrachromosomal DNA in cancer	1
Epigenetic remodelling drives fibroid development	1
Investigating immune cells across time in vivo	1
Cancer burden in low-income and middle-income countries	1