Nature Reviews Cancer

Article	Citations
Computing brain metastasis impact	1770
Digging for treasures in the tumour interactome	1268
An inhospitable site	668
Combining spatial transcriptomics and AI to enhance brain tumour diagnosis	623
Fructose takes a detour to feed cancer	615
Implementing practice-changing progress for managing cancer of unknown primary	412
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment	411
Emerging strategies to investigate the biology of early cancer	409
Oncofetal reprogramming in tumour development and progression	407
INVADEseq to study the intratumoural microbiota at host single-cell resolution	391
Exploiting metabolic cell death for cancer therapy	356
Combinatorial strategies to target RAS-driven cancers	354
How medical anthropology can contribute to cancer research	347
Mapping the prostate cell family tree	342
Fighting cancer with fat	324
Reply to ‘Heterogeneity of TP53 mutations necessitates differentiation with p53-rescue therapies’	302
The recruitment of metastasis-associated monocytes	283
Epithelial and stromal co-evolution and complicity in pancreatic cancer	272
3D chromatin architecture as a predictor of somatic mutations in cancer genomes	255
The evolution of cancer and ageing: a history of constraint	236
Translating premalignant biology to accelerate non-small-cell lung cancer interception	233
Context-dependent functions of pattern recognition receptors in cancer	229
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel	228
Author Correction: Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma	226
Gut microbes produce novel genotoxic metabolites	221

Connie J. Eaves (1944–2024)	221
The role of CRAF in cancer progression: from molecular mechanisms to precision therapies	221
Tertiary lymphoid structures as hubs of antitumour immunity	221
No mutation, tumour initiation	201
Nanoreceptors take down mutant p53	201
Impersonating neurons	199
Dendritic cells rise and shine	198
Tumour EVPs disrupt liver function	194
AACR 2025	187
Measuring HLA disruption using MHC Hammer	175
Persistence is key	173
Thelpers? More like Ttroublemakers	172
Remodelling of the tumour microenvironment by the kallikrein-related peptidases	172
Removing barriers to address sex differences in anticancer drug toxicity	165
Moonlighting functions of glucose metabolic enzymes and metabolites in cancer	164
Defining a ‘cells to society’ research framework for appendiceal tumours	164
How chemokines organize the tumour microenvironment	156
3D bioprinted cancer models: from basic biology to drug development	155
Natural killer cells in antitumour adoptive cell immunotherapy	150
Bone voyage: immune crosstalk sets sail	145
B-ring sterols to the rescue	142
Visualizing intratumoural heterogeneity with EpicMIBI	140
Points of entry for tumour-infiltrating lymphocytes	139
Environmental endocrine disruptors: rethinking the origins of early-onset ER+ breast cancer	136
The immune microenvironment of colorectal cancer	135
Identifying spatial cellular structures with SPACE-GM	135
In-depth organoid profiling of pancreatic cancer	133
Regulatory T cells in the tumour microenvironment	127
Un-Fair Skin: racial disparities in acral melanoma research	127
Metabolic interplays between the tumour and the host shape the tumour macroenvironment	127
Leveraging the replication stress response to optimize cancer therapy	126
The path to leptomeningeal metastasis	123
Linking cell mechanical memory and cancer metastasis	120
Dynamics and specificities of T cells in cancer immunotherapy	115
In situ decellularization of tissues to resolve the tumour-associated matrix	114
Understanding and addressing race disparities in childhood cancer outcomes	108
Encoding spatial tumour dynamics with Starfysh	107
Race influences the tumour microbiome	106
Deciphering the cancer genome and epigenome	101
The link between vitamin D and prostate cancer	99
Don’t blame the messenger: lessons learned for cancer mRNA vaccines during the COVID-19 pandemic	97
Polygenic scores in cancer	96
Being in the zone	89
ER stress sparks nerve pain	89
Targeted protein degradation for cancer therapy	88
Cancer nanomedicine	87
Acetyl-CoA metabolism in cancer	84
RNA splicing dysregulation and the hallmarks of cancer	83
Z-nucleic acids give immunotherapy a boost	81
Local CAR manufacturing	79

Author Correction: Antibody-based proteomics: fast-tracking molecular diagnostics in oncology	78
Parity modulates epithelial–immune cell communication	78
Prime editing GEMMs to model cancer mutations	75
A trojan horse to target spliceosome mutant cells	71
NOTUM-mediated stem cell competition in CRC	71
Tamoxifen takes the wheel	70
Expanding the utility of precision oncology knowledge bases	68
Right ON target: a new RAS-GTP inhibitor	66
Defining precancer: a grand challenge for the cancer community	61
Integrative medicine in oncology: redefining the standard of care	59
Chromothripsis in cancer	57
Tertiary lymphoid structures in anticancer immunity	55
Targeting ferroptosis as a vulnerability in cancer	54
Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities	54
Neutrophils: a roadblock for immunotherapy	53
In vivo labelling system to study cell neighbourhoods	52
Revealing genomic secrets of archival FFPE samples	51
Judith Campisi (1948–2024)	51
Quantum probes in cancer research	50
Functional lineage tracing to study the clonal evolution of therapy resistance	48
New pathogen on the block	48
Melanomagenesis antagonizes stem cell ageing	46
Inferring cancer metabolism from gene-expression data	46
N6-Methyladenosine: an RNA modification as a central regulator of cancer	45
Immune-checkpoint inhibitor-mediated myocarditis: CTLA4, PD1 and LAG3 in the heart	44
Recent advances in therapeutic cancer vaccines	43
The present and future of the Cancer Dependency Map	42
Carcinogenesis at single-cell resolution	42
Patient-derived organoids unveil sarcoma vulnerabilities	41
Epigenomic heterogeneity as a source of tumour evolution	40
Bidirectional CART.BiTE cells bring new hope	40
Global post-mortem tissue donation programmes to accelerate cancer research	38
Focusing on the complex and dynamic interplay between ageing and cancer	37
Transfer RNAs as dynamic and critical regulators of cancer progression	35
A timeline of tumour-associated macrophage biology	35
Developing dietary interventions as therapy for cancer	35
Traject3d for studying 3D cellular heterogeneity	34
Author Correction: Integrative medicine in oncology: redefining the standard of care	34
Digitally enhanced Raman spectroscopy	33
Harnessing the influenza virus to fight cancer	32
Targeting cancer cell dormancy	31
Fcγ receptors and immunomodulatory antibodies in cancer	30
Mechanisms and treatment of cancer therapy-induced peripheral and central neurotoxicity	30
Structural variations in cancer and the 3D genome	28
Mechanisms, challenges and opportunities for FLASH radiotherapy in cancer	28
Neuro-immune cross-talk in cancer	27
The role of ROS in tumour development and progression	25
Guardrails for the use of generalist AI in cancer care	25
We cannot ignore the cancer risks of wildfires	25
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity	24
mRNA-based cancer therapeutics	24
AACR 2024	23
Next-generation epidemiologic cohorts for cancer aetiology	23
Ethnically diverse cancer cell lines for drug testing	22
Male melanoma comes of age	21
Modelling and deciphering tumour metabolism in CRISPR screens	20
Fungi in cancer: not such a ‘fun-guy’	20
CAFs promote CRPC	19
Mechanisms driving the immunoregulatory function of cancer cells	19
EMT in chemoresistance	19
The role of eIF4F-driven mRNA translation in regulating the tumour microenvironment	18
Advances in cutaneous squamous cell carcinoma	17
Decoding the functional impact of the cancer genome through protein–protein interactions	17
Silent mutations make noise	16
Energizing leukaemia	16
Author Correction: Learning to distinguish progressive and non-progressive ductal carcinoma in situ	16
Multiomics-guided cellular immunotherapies	15
Same same but different	15
Inflammatory neutrophils	15
Key role for microbiota in gut–bone crosstalk	14
Decoding the basis of histological variation in human cancer	14
Disconnecting multicellular networks in brain tumours	13
Advances in translational research of the rare cancer type adrenocortical carcinoma	12
Exploiting senescence for the treatment of cancer	12
Stemness in solid malignancies: coping with immune attack	12
Deep tissue imaging of cancer in the infrared	12
Therapeutic resistance to anti-oestrogen therapy in breast cancer	12
Glioblastomas remodel neural circuits	11
Enhanced transposable elements	11
Air pollution promotes tumorigenesis through pre-existing oncogenic mutations	10

Addressing the gaps in cancer screening for LGBTQ+ individuals	10
Too much of a good thing	9
Mapping out mitochondria	9
Fungi in cancer	8
Overcoming heterogeneity with 3D whole-tumour sampling	8
Androgen receptor activation for breast cancer therapy	8
Targeting sex steroid biosynthesis for breast and prostate cancer therapy	8
Black voices in cancer research and oncology	8
Aristolochic acid-associated cancers: a public health risk in need of global action	8
Pathogenesis of cancers derived from thyroid follicular cells	8
Limiting bias in AI models for improved and equitable cancer care	8
Nucleotide metabolism: a pan-cancer metabolic dependency	7
Breast milk for breast cancer detection	7
Big data in basic and translational cancer research	7
Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection	7
Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment	7
Tumour avatars to model patients’ responses to immunotherapy	6
Feeding latent brain metastasis	6
Conventional chemotherapy: millions of cures, unresolved therapeutic index	6
Intercepting gastric cancer	6
Proximity labelling to study chromatin interactomes	6
Modelling the ageing dependence of cancer evolutionary trajectories	6
Polyamines in cancer: integrating organismal metabolism and antitumour immunity	5
VIBRANT: mapping cell phenotypes using vibrational spectroscopy	5
Understanding tumour endothelial cell heterogeneity and function from single-cell omics	5
Epigenetic memory	5
Protection against tumour formation	5
The fibroinflammatory response in cancer	5
Obesity as a promoter in BRCA mutation carriers	5
Small speckles, big impact	5
Defining and using immune archetypes to classify and treat cancer	5
Replication timings affect the frequency of chromosomal translocation	4
Lymphatic vessels in the age of cancer immunotherapy	4
Tracing the evolutionary history of breast cancer	4
Exploiting temporal aspects of cancer immunotherapy	4
scAtlasVAE: a deep learning framework for generating a human CD8+ T cell atlas	4
Studying extrachromosomal DNA with the ecTag method	4
Enhancing cellular immunotherapies in cancer by engineering selective therapeutic resistance	4
Multiplex protein imaging in tumour biology	4
A machine learning toolkit for subtyping cancer in existing and new datasets	4
Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma	4
Targeting the roots of myeloid malignancies with T cell receptors	4
Sex affects cancer genomes	3
Lactate gives a sour taste	3
The dynamic role of platelets in cancer progression and their therapeutic implications	3
Epigenetic lesions drive gliomagenesis	3
Aggregating premalignancy	3
Presenting fibroblasts	3
Heard immunity in CAR T cells	3
Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities	3
Hidden epithelial subtypes refine colorectal cancer classification	3
Cancer’s sensory experience	3
Rusting away with age	3
Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications	3
Ageing lipids map melanoma’s journey	3
Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention	3
Stromal cells drive tumorigenesis in BRCA1 mutation carriers	3
Taking a detour	3
PDX models for functional precision oncology and discovery science	3
Targeting the tumour’s little helpers	2
A guide to transcriptomic deconvolution in cancer	2
How protons pave the way to aggressive cancers	2
Targeting aberrant splicing	2
Naughty neutrophils	2
Activated neutrophils: the anti-hero	2
Characterization of the B cell receptor repertoire in melanoma	2
Why do patients with cancer die?	2
Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities	2
The advent of immune stimulating CAFs in cancer	2
Tryptophan metabolite improves PDAC response rates and survival	2
NET-working under stress	2
Cancer progression through the lens of age-induced metabolic reprogramming	2
Identification, functional insights and therapeutic targeting of EMT tumour states	2
Advancing cancer research via comparative oncology	2
Oncologists must act to manage cancer detected through prenatal screening	2
Nanotherapy: targeting the tumour microenvironment	2
Unlocking the potential of FinnGen to advance cancer research	2
Investigating immune cells across time in vivo	2
Eph receptors and ephrins in cancer progression	2
Cancers make their own luck: theories of cancer origins	2
Translating p53-based therapies for cancer into the clinic	2
Challenging the status quo to improve the translational potential of preclinical oncology studies	2
Author Correction: The importance of 3D fibre architecture in cancer and implications for biomaterial model design	2
Circular RNA in cancer	2
Mastering the use of cellular barcoding to explore cancer heterogeneity	2
Expanding oesophageal cancer research and care in eastern Africa	2
CRISPR in cancer biology and therapy	2
Gender and sex interactions are intrinsic components of cancer phenotypes	2
Unlocking the potential of urine-based liquid biopsy through improved reporting and standardization	2
Towards targeting transposable elements for cancer therapy	2
STAT proteins in cancer: orchestration of metabolism	2
Tumour-derived d-2HG blocks T cell cytotoxicity	2
How cancer reduces motivation	2
Pressing defence	2
Tracking genome evolution following p53 inactivation	2