Aging Cell

Article	Citations
Issue Information	197
Associations of combined accelerated biological aging and genetic susceptibility with incidence of heart failure in a population‐based cohort study	139
Effects of Aging on Glucose and Lipid Metabolism in Mice	131
Increased levels of extracellular matrix proteins associated with extracellular vesicles from brains of aged mice	123
Circadian regulation in aging: Implications for spaceflight and life on earth	121
Cooperative effects of SIRT1 and SIRT2 on APP acetylation	115
Featured Cover	104
Age‐related changes in metabolites in young donor livers and old recipient sera after liver transplantation from young to old rats	104
Compromised CD8+ T cell immunity in the aged brain increases severity of neurotropic coronavirus infection and postinfectious cognitive impairment	102
Inflammatory and immune markers in HIV‐infected older adults on long‐term antiretroviral therapy: Persistent elevation of sCD14 and of proinflammatory effector memory T cells	94
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Telomere length and micronuclei trajectories in APP/PS1 mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic ma	88
Chronic TNF exposure induces glucocorticoid‐like immunosuppression in the alveolar macrophages of aged mice that enhances their susceptibility to pneumonia	79
Expression of mitochondrial oxidative stress response genes in muscle is associated with mitochondrial respiration, physical performance, and muscle mass in the Study of Muscle, Mobility, and Aging	78
SCARF2 is a target for chronic obstructive pulmonary disease: Evidence from multi‐omics research and cohort validation	77
A p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo	73
Oral Citrate Supplementation Mitigates Age‐Associated Pathologic Intervertebral Disc Calcification in LG/J Mice	71
Correlates of life course physical activity in participants of the Baltimore longitudinal study of aging	70
Aging influences the cardiac macrophage phenotype and function during steady state and during inflammation	69
Long‐term Tai Chi practice in older adults is associated with “younger” functional abilities	66
Lipid peroxidation products induce carbonyl stress, mitochondrial dysfunction, and cellular senescence in human and murine cells	65
Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy	65
Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain	62
Blood–brain barrier dysfunction promotes astrocyte senescence through albumin‐induced TGFβ signaling activation	62
Epigenetic clock and methylation studies in elephants	61

Telomere Position Effect‐Over Long Distances Acts as a Genome‐Wide Epigenetic Regulator Through a Common Alu Element	59
Cisd2 slows down liver aging and attenuates age‐related metabolic dysfunction in male mice	59
Advanced age and female sex protect cerebral arteries from mitochondrial depolarization and apoptosis during acute oxidative stress	58
Role of autophagy in aging: The good, the bad, and the ugly	58
Age‐dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging	57
Alpha‐ketoglutarate ameliorates age‐related and surgery induced temporomandibular joint osteoarthritis via regulating IKK/NF‐κB signaling	56
Nanocarriers for natural polyphenol senotherapeutics	56
Longitudinal analysis of physical function in older adults: The effects of physical inactivity and exercise training	54
Issue Information	53
Dysregulated nicotinamide adenine dinucleotide metabolome in patients hospitalized with COVID‐19	53
Enhanced NRF2 expression mitigates the decline in neural stem cell function during aging	53
Targeting TGF‐β signaling, oxidative stress, and cellular senescence rescues osteoporosis in gerodermia osteodysplastica	53
S‐adenosyl‐L‐homocysteine extends lifespan through methionine restriction effects	53
Anatomical Society Research Studentships 2023/24	52
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Cockayne syndrome B protein is implicated in transcription and associated chromatin dynamics in homeostatic and genotoxic conditions	51
Association between prescription drugs and all‐cause mortality risk in the UK population	51
Hippocampal rejuvenation by a single intracerebral injection of one‐carbon metabolites in C57BL6 old wild‐type mice	51
Corrigendum to: Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction	49
Corrigendum to: Cap‐independent translation of GPLD1 enhances markers of brain health in long‐lived mutant and drug‐treated mice	47
Cellular senescence contributes to spontaneous repair of the rat meniscus	47
Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis	46
Reduced bone morphogenic protein signaling along the gut–neuron axis by heat shock factor promotes longevity	46
Alterations of lipid‐mediated mitophagy result in aging‐dependent sensorimotor defects	46
The role of cardiac resident macrophage in cardiac aging	46
Skeletal muscle DNA methylation: Effects of exercise and HIV	46
Young donor hematopoietic stem cells revitalize aged or damaged bone marrow niche by transdifferentiating into functional niche cells	46
4‐phenylbutyric acid—Identity crisis; can it act as a translation inhibitor?	46
Heterozygous OT‐I mice reveal that antigen‐specific CD8+ T cells shift from apoptotic to necrotic killers in the elderly	44
Discovery of genomic and transcriptomic pleiotropy between kidney function and soluble receptor for advanced glycation end products using correlated meta‐analyses: The Long Life Family Study	44
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Mechanisms of angiogenic incompetence in Hutchinson–Gilford progeria via downregulation of endothelial NOS	43
Trends of genetic contributions on epigenetic clocks and related methylation sites with aging: A population‐based adult twin study	42
Vitamin D3 inhibits p38 MAPK and senescence‐associated inflammatory mediator secretion by senescent fibroblasts that impacts immune responses during ageing	42
Type I Interferon signaling controls the accumulation and transcriptomes of monocytes in the aged lung	42
Chemically induced senescence in human stem cell‐derived neurons promotes phenotypic presentation of neurodegeneration	42
Endothelial‐specific telomerase inactivation causes telomere‐independent cell senescence and multi‐organ dysfunction characteristic of aging	41
Ecological Realism Accelerates Epigenetic Aging in Mice	41
CALB1 and RPL23 Are Essential for Maintaining Oocyte Quality and Function During Aging	41
DNA methylation and chromatin accessibility predict age in the domestic dog	41
Cell nonautonomous roles of NHR‐49 in promoting longevity and innate immunity	40
Age‐dependent aneuploidy in mammalian oocytes instigated at the second meiotic division	40
Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization	39
3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex	39
Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species	39
Degradation of cochlear Connexin26 accelerate the development of age‐related hearing loss	38
Deciphering the role of immune cell composition in epigenetic age acceleration: Insights from cell‐type deconvolution applied to human blood epigenetic clocks	38
Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson‐Gilford Progeria syndrome	38
Amyloid‐β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk‐AMPK pathway	38
Accelerated biological aging, healthy behaviors, and genetic susceptibility with incidence of stroke and its subtypes: A prospective cohort study	37

Altered tubulin detyrosination due to SVBP malfunction induces cytokinesis failure and senescence, underlying a complex hereditary spastic paraplegia	37
Lipoteichoic acid restrains macrophage senescence via β‐catenin/FOXO1/REDD1 pathway in age‐related osteoporosis	37
Anatomical Society Research Studentships 2025/26	37
Intestinal stem cell aging at single‐cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics	37
Issue Information	36
Form follows function: Nuclear morphology as a quantifiable predictor of cellular senescence	36
Early resilience and epigenetic ageing: Results from the prospective Young Finns Study with a 31‐year follow‐up	36
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The Redox Activity of Protein Disulphide Isomerase Functions in Non‐Homologous End‐Joining Repair to Prevent DNA Damage	36
Cardiomyocyte Pdk4 response is associated with metabolic maladaptation in aging	35
High plasma concentrations of acyl‐coenzyme A binding protein (ACBP) predispose to cardiovascular disease: Evidence for a phylogenetically conserved proaging function of ACBP	35
Homocysteine potentiates amyloid β‐induced death receptor 4‐ and 5‐mediated cerebral endothelial cell apoptosis, blood brain barrier dysfunction and angiogenic impairment	35
Chaperone‐mediated autophagy degrades Keap1 and promotes Nrf2‐mediated antioxidative response	35
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Enhanced insulin‐regulated phagocytic activities support extreme health span and longevity in multiple populations	35
dVGLUT Is a Mediator of Sex Differences in Dopamine Neuron Mitochondrial Function Across Aging and in a Parkinson's Disease Model	34
Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro‐BDNF in older adults with prediabetes	34
Epigenetic age oscillates during the day	34
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis	34
Aging and cancer epigenetics: Where do the paths fork?	34
Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity	34
AP‐1 is a regulatory transcription factor of inflammaging in the murine kidney and liver	33
Fkbp5 gene deletion: Circadian rhythm profile and brain proteomics in aged mice	33
Peripheral inflammatory biomarkers are associated with cognitive function and dementia: Framingham Heart Study Offspring cohort	33
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Genetically determined blood pressure, antihypertensive drug classes, and frailty: A Mendelian randomization study	33
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Age‐Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light‐Induced Outer Retinal Degeneration in Mice	32
Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice	32
Improved cognitive impairments by silencing DMP1 via enhancing the proliferation of neural progenitor cell in Alzheimer‐like mice	32
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Network‐based cytokine inference implicates Oncostatin M as a driver of an inflammation phenotype in knee osteoarthritis	31
Myeloid ectopic viral integration site 2 accelerates the progression of Alzheimer's disease	31
Delayed formation of neural representations of space in aged mice	31
Downregulation of PLIN2 in human dermal fibroblasts impairs mitochondrial function in an age‐dependent fashion and induces cell senescence via GDF15	31
Senescence detection using reflected light	31
Intact mitochondrial function in the setting of telomere‐induced senescence	31
Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice	31
LEMD2‐associated progeroid syndrome: Expanding the phenotype of the nuclear envelopathy caused by a defect in LEMD2 gene	31
Targeted sequencing of the 9p21.3 region reveals association with reduced disease risks in Ashkenazi Jewish centenarians	31
P2Y2 Inhibition Modifies the Anabolic Response to Exercise in Adult Mice	30
Inhibition of unfolded protein response prevents post‐anesthesia neuronal hyperactivity and synapse loss in aged mice	30
Glycation‐mediated tissue‐level remodeling of brain meningeal membrane by aging	30
Exerkine FNDC5/irisin‐enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin‐1	30
Ipriflavone as a non‐steroidal glucocorticoid receptor antagonist ameliorates diabetic cognitive impairment in mice	29
Cochlear Neurotrophin‐3 overexpression at mid‐life prevents age‐related inner hair cell synaptopathy and slows age‐related hearing loss	29
B cell‐intrinsic changes with age do not impact antibody‐secreting cell formation but delay B cell participation in the germinal centre reaction	29
Ketogenic β‐hydroxybutyrate regulates β‐hydroxybutyrylation of TCA cycle‐associated enzymes and attenuates disease‐associated pathologies in Alzheimer's mice	29
Proteo‐metabolomic insights for early dual physical and cognitive impairments: A search for biomarkers of healthy aging based on muscle–brain crosstalk	29
Single‐cell RNA sequencing reveals the CRTAC1+ population actively contributes to the pathogenesis of spinal ligament degeneration by SPP1+ macro	29
Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics	29
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Stiffening symphony of aging: Biophysical changes in senescent osteocytes	28
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Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma	28
Necroptosis contributes to chronic inflammation and fibrosis in aging liver	28
Macrophage Subpopulation Promotes Skeletal Muscle Regeneration Through HGF/MET Signaling‐Mediated Skeletal Muscle Stem Cell Proliferation	28
Proteomic analysis across aged tissues reveals distinct signatures and the crucial involvement of midgut barrier function in the regulation of aging	28
Exploring Lymph Node Stroma Ageing: Immune Implications and Future Directions	28
DeepQA: A Unified Transcriptome‐Based Aging Clock Using Deep Neural Networks	28
Development of a Short Telomere Zebrafish Model for Accelerated Aging Research and Antiaging Drug Screening	28
Isolating the direct effects of growth hormone on lifespan and metabolism in mice	28
circSIRT2/miR‐542‐3p/VASH1 axis regulates endothelial‐to‐mesenchymal transition (EndMT) in subretinal fibrosis in age‐related macular degeneration models	28
Telomerase reverse transcriptase gene knock‐in unleashes enhanced longevity and accelerated damage repair in mice	28
Senolytics alleviate the degenerative disorders of temporomandibular joint in old age	27
Lithium can mildly increase health during ageing but not lifespan in mice	27
Intermittent Fasting Enhances Motor Coordination Through Myelin Preservation in Aged Mice	27
Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4‐induced brain pathology	27
The cellular bases of mobility from the Study of Muscle, Mobility and Aging (SOMMA)	27
Donor BMSC‐derived small extracellular vesicles relieve acute rejection post‐renal allograft through transmitting Loc108349490 to dendritic cells	27
A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease	26
Ghrelin delays premature aging in Hutchinson‐Gilford progeria syndrome	26
Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence	26
Age‐ and disease‐related autophagy impairment in Huntington disease: New insights from direct neuronal reprogramming	26
Age‐related memory vulnerability to interfering stimuli is caused by gradual loss of MAPK‐dependent protection in Drosophila	26
NMR metabolomic modeling of age and lifespan: A multicohort analysis	26
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Fusion and expansion of vitellogenin vesicles during Caenorhabditis elegans intestinal senescence	26
A novel framework to build saliva‐based DNA methylation biomarkers: Quantifying systemic chronic inflammation as a case study	26

Age‐related thymic involution: Mechanisms and functional impact	25
Age‐dependent NMDA receptor function is regulated by the amyloid precursor protein	25
A novel senolytic drug for pulmonary fibrosis: BTSA1 targets apoptosis of senescent myofibroblasts by activating BAX	25
Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function	25
Muscle mitochondrial energetics predicts mobility decline in well‐functioning older adults: The baltimore longitudinal study of aging	25
Issue Information	25
Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal‐dominant Alzheimer's disease	25
Sirt1 overexpression improves senescence‐associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL‐11 transcription	25
Knockdown of astrocytic Grin2a aggravates β‐amyloid‐induced memory and cognitive deficits through regulating nerve growth factor	25
Correction to ‘Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single‐cell analysis’	25
Insights into T‐cell dysfunction in Alzheimer's disease	25
Contextualizing aging clocks and properly describing biological age	25
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SQSTM1/p62 Orchestrates Skin Aging via USP7 Degradation	24
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Optimising Age‐Specific Insulin Signalling to Slow Down Reproductive Ageing Increases Fitness in Different Nutritional Environments	24
Morphological phenotyping of the aging cochlea in inbred C57BL/6N and outbred CD1 mouse strains	24
Comparative single‐cell transcriptomic analysis across tissues of aging primates reveals specific autologous activation of ZNF281 to mitigate oxidative stress in cornea	24
Aβ ‐induced excessive mitochondrial fission drives type H blood vessels injury to aggravate bone loss in APP/PS1 mice with Alzheimer's diseases	24
TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1	24
Senescent Macrophages Promote Age‐Related Revascularization Impairment by Increasing Antiangiogenic VEGF‐A165B Expression	24
Mechanistic Insights Into 5′‐tiRNA‐His‐GTG Mediated Activation of the JNK Pathway in Skin Photoaging	24
Issue Information	24
Aging clock based on nucleosome reorganisation derived from cell‐free DNA	23
Accelerated replicative senescence of ataxia‐telangiectasia skin fibroblasts is retained at physiologic oxygen levels, with unique and common transcriptional patterns	23
Anatomical Society Research Studentships 2025/26	23
Hungry for biomarkers of aging	23
Prepubertal castration eliminates sex differences in lifespan and growth trajectories in genetically heterogeneous mice	23
Pro‐inflammatory cytokine 11 plays a pivotal role in inflammaging‐associated pathologies	23
Enhancing mask activity in dopaminergic neurons extends lifespan in flies	23
Downregulation of ROR2 promotes dental pulp stem cell senescence by inhibiting STK4‐FOXO1/SMS1 axis in sphingomyelin biosynthesis	23
Quantitative restoration of immune defense in old animals determined by naive antigen‐specific CD8 T‐cell numbers	22
Plasma proteomic signature of decline in gait speed and grip strength	22
Nicotinamide riboside intervention alleviates hematopoietic system injury of ionizing radiation‐induced premature aging mice	22
Bone dysplasia in Hutchinson‐Gilford progeria syndrome is associated with dysregulated differentiation and function of bone cell populations	22
ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds	22
Large‐scale genetic screens identify BET‐1 as a cytoskeleton regulator promoting actin function and life span	22
Whole‐genome methylation analysis of aging human tissues identifies age‐related changes in developmental and neurological pathways	21
Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence	21
The lysosomal proteome of senescent cells contributes to the senescence secretome	21
Proteomic aging clock (PAC) predicts age‐related outcomes in middle‐aged and older adults	21
The SATB1‐MIR22‐GBA axis mediates glucocerebroside accumulation inducing a cellular senescence‐like phenotype in dopaminergic neurons	21
Aging‐associated decrease of PGC‐1α promotes pain chronification	21
Age‐dependent loss of hepatic SIRT1 enhances NLRP3 inflammasome signaling and impairs capacity for liver fibrosis resolution	21
Dual treatment with kynurenine pathway inhibitors and NAD+ precursors synergistically extends life span in Drosophila	21
Age‐related increase of CD38 directs osteoclastogenic potential of monocytic myeloid‐derived suppressor cells through mitochondrial dysfunction in male mice	21
Innate immune remodeling by short‐term intensive fasting	21
Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis	21
Effect of canakinumab on frailty: A post hoc analysis of the CANTOS trial	21
Deep Characterization of Isomerization in the Human Eye Lens Proteome by Crystallin‐Depleted Data‐Independent Acquisition	20
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Chronic polypharmacy, monotherapy, and deprescribing: Understanding complex effects on the hepatic proteome of aging mice	20
Nucleoporin93 limits Yap activity to prevent endothelial cell senescence	20
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Progeria‐based vascular model identifies networks associated with cardiovascular aging and disease	20
TAF15 downregulation contributes to the benefits of physical training on dendritic spines and working memory in aged mice	20
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Diet composition, adherence to calorie restriction, and cardiometabolic disease risk modification	20
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Oocyte aging is controlled by mitogen‐activated protein kinase signaling	19
Platelet biomarkers identifying mild cognitive impairment in type 2 diabetes patients	19
Single‐Cell RNA‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury	19
Late‐life plasma proteins associated with prevalent and incident frailty: A proteomic analysis	19
Dysregulated glial genes in Alzheimer's disease are essential for homeostatic plasticity: Evidence from integrative epigenetic and single cell analyses	19
Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer’s disease	19
Organelle dysfunction upon asrij depletion causes aging‐like changes in mouse hematopoietic stem cells	19
Plasma Proteomic Signature as a Predictor of Age Advancement in People Living With HIV	19
Associations between skeletal muscle energetics and accelerometry‐based performance fatigability: Study of Muscle, Mobility and Aging	19
Loss of heterochromatin and retrotransposon silencing as determinants in oocyte aging	19
Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging	19
Abalone peptide increases stress resilience and cost‐free longevity via SKN‐1‐governed transcriptional metabolic reprogramming in C. elegans	19
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Overexpression of mitochondrial fission or mitochondrial fusion genes enhances resilience and extends longevity	19
Tgm2‐Catalyzed Covalent Cross‐Linking of IκBα Drives NF‐κB Nuclear Translocation to Promote SASP in Senescent Microglia	19
Chronic β3‐AR stimulation activates distinct thermogenic mechanisms in brown and white adipose tissue and improves systemic metabolism in aged mice	19
A molecular index for biological age identified from the metabolome and senescence‐associated secretome in humans	18
A circular intronic RNA ciPVT1 delays endothelial cell senescence by regulating the miR‐24‐3p/CDK4/pRb axis	18
Sensitivity of the S1 neuronal calcium network to insulin and Bay‐K 8644 in vivo: Relationship to gait, motivation, and aging processes	18
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Physical Exercise Decreases Complement‐Mediated Synaptic Loss and Protects Against Cognitive Impairment by Inhibiting Microglial Tmem9‐ATP6V0D1 in Alzheimer's Disease	18
Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan	18
rDNA Copy Number Variation and Methylation During Normal and Premature Aging	18
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Long term methionine restriction: Influence on gut microbiome and metabolic characteristics	18
Age‐related dysregulation of the retinal transcriptome in African turquoise killifish	18
Astrocytic Hevin/SPARCL‐1 Regulates Cognitive Decline in Pathological and Normal Brain Aging	18
Integrated multi‐omic analyses uncover the effects of aging on cell‐type regulation in glucose‐responsive tissues	18
Rejuvenation of neutrophils and their extracellular vesicles is associated with enhanced aged fracture healing	18
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The physiologic complexity of beat‐to‐beat blood pressure is associated with age‐related alterations in blood pressure regulation	18
HLH‐30/TFEB Rewires the Chaperone Network to Promote Proteostasis Upon Perturbations to the Coenzyme A and Iron–Sulfur Cluster Biosynthesis Pathways	17
Acetyltransferase p300 regulates atrial fibroblast senescence and age‐related atrial fibrosis through p53/Smad3 axis	17
Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic	17