OOIR: Observatory of International Research

Papers

(The TQCC of Aging Cell is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation	290
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice	184
Underlying features of epigenetic aging clocks in vivo and in vitro	115
Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo	105
Ovarian stiffness increases with age in the mammalian ovary and depends on collagen and hyaluronan matrices	100
COVID‐19 is an emergent disease of aging	94
Targeting miR‐124/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model	93
Determinants of accelerated metabolomic and epigenetic aging in a UK cohort	92
On the evolution of cellular senescence	83
Epigenetic age prediction	82
A genome‐wide association study of the frailty index highlights brain pathways in ageing	78
Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans	78
Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery	78
Mitochondrial DNA in extracellular vesicles declines with age	75
mTORC2: The other mTOR in autophagy regulation	75
Aging aggravated liver ischemia and reperfusion injury by promoting STING‐mediated NLRP3 activation in macrophages	72
Clonal hematopoiesis associated with epigenetic aging and clinical outcomes	72
Cellular senescence as a potential mediator of COVID‐19 severity in the elderly	71
Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity	70
Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus	69
Thyroid hormones in diabetes, cancer, and aging	67
Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging	67
Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling	65
Necroptosis contributes to chronic inflammation and fibrosis in aging liver	65
Animal models of sarcopenia	63

Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice	62
DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: the DAMA study	62
BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy	61
Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging	60
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming	57
Proteomics in aging research: A roadmap to clinical, translational research	57
Plasma proteomic profile of age, health span, and all‐cause mortality in older adults	56
NAD⁺ supplementation prevents STING‐induced senescence in ataxia telangiectasia by improving mitophagy	56
The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high‐fat diet‐fed obese rats	53
Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells	53
Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus	53
Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease	53
The role of senescent T cells in immunopathology	51
α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease	50
Klotho overexpression improves amyloid‐β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease	49
miR‐181a regulates p62/SQSTM1, parkin, and protein DJ‐1 promoting mitochondrial dynamics in skeletal muscle aging	48
17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex	48
Nuclear envelope dysfunction and its contribution to the aging process	48
Aging is associated with a decline in Atg9b‐mediated autophagosome formation and appearance of enlarged mitochondria in the heart	47
Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects	47
MiR‐103‐3p targets the m⁶A methyltransferase METTL14 to inhibit osteoblastic bone formation	47
Exercise reduces circulating biomarkers of cellular senescence in humans	46
Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation	45
Exercise training reverses cardiac aging phenotypes associated with heart failure with preserved ejection fraction in male mice	45
Single human oocyte transcriptome analysis reveals distinct maturation stage‐dependent pathways impacted by age	44
JUNB‐FBXO21‐ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy	44
Fibronectin type III domain‐containing 5 improves aging‐related cardiac dysfunction in mice	44
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis	44
Senescent cells and the incidence of age‐related diseases	43
Aging and sex: Impact on microglia phagocytosis	43
Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD⁺ redox	43
Epigenetic clock and methylation studies in elephants	43
Microglial MT1 activation inhibits LPS‐induced neuroinflammation via regulation of metabolic reprogramming	43
Sirt1 sustains female fertility by slowing age‐related decline in oocyte quality required for post‐fertilization embryo development	43
Poly (ADP‐ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α‐synuclein degradation via transcription factor EB‐dependent autophagy in mutant α‐synucleinA53T model of Parkinson's	43
The ketogenic diet preserves skeletal muscle with aging in mice	42
Alterations in mitochondrial dynamics with age‐related Sirtuin1/Sirtuin3 deficiency impair cardiomyocyte contractility	42
Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans	41
Is exercise a senolytic medicine? A systematic review	41
Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids	40
Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity	40
Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson–Gilford Progeria Syndrome	40
Repetitive elements as a transcriptomic marker of aging: Evidence in multiple datasets and models	39
Insights into T‐cell dysfunction in Alzheimer's disease	39
Alzheimer’s amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood‐brain barrier integrity, and angiogenesis	39
Anti‐inflammatory treatment rescues memory deficits during aging in nfkb1^−/− mice	38
SS‐31 and NMN: Two paths to improve metabolism and function in aged hearts	38
Vascular dysfunction in aged mice contributes to persistent lung fibrosis	38
ATF3 drives senescence by reconstructing accessible chromatin profiles	37
Type I interferons and related pathways in cell senescence	37

Metformin inhibits chronic kidney disease‐induced DNA damage and senescence of mesenchymal stem cells	37
Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells	37
G6PDoverexpression protects from oxidative stress and age‐related hearing loss	36
Functional genomic analyses highlight a shift in Gpr17‐regulated cellular processes in oligodendrocyte progenitor cells and underlying myelin dysregulation in the aged mouse cerebrum	36
RTN4B‐mediated suppression of Sirtuin 2 activity ameliorates β‐amyloid pathology and cognitive impairment in Alzheimer's disease mouse model	36
Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss	36
YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling	36
Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age	35
Genetic associations for two biological age measures point to distinct aging phenotypes	35
Interleukin‐6 neutralization ameliorates symptoms in prematurely aged mice	35
Sex‐specific aging in animals: Perspective and future directions	35
Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging	34
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway	34
Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging	34
α‐ketoglutarate delays age‐related fertility decline in mammals	33
PPARγ agonists delay age‐associated metabolic disease and extend longevity	33
TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1	33
Chronic low‐grade inflammation in heart failure with preserved ejection fraction	33
Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice	33
Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats	33
Muscle mitochondrial energetics predicts mobility decline in well‐functioning older adults: The baltimore longitudinal study of aging	32
Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro‐inflammatory cytokines	32
Antiallergic drug desloratadine as a selective antagonist of 5HT_2A receptor ameliorates pathology of Alzheimer's disease model mice by improving microglial dysfunction	32
Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease	31
Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization	31
Age‐related changes in hippocampal‐dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor	31
Body weight and high‐fat diet are associated with epigenetic aging in female members of the BXD murine family	31
Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress‐induced mitochondrial dysfunction	31
Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice	31
Ibrutinib modulates Aβ/tau pathology, neuroinflammation, and cognitive function in mouse models of Alzheimer's disease	31
Age‐related thymic involution: Mechanisms and functional impact	30
Parallels between retinal and brain pathology and response to immunotherapy in old, late‐stage Alzheimer's disease mouse models	30
Disruption of ER‐mitochondria tethering and signalling in C9orf72‐associated amyotrophic lateral sclerosis and frontotemporal dementia	30
Modeling the human aging transcriptome across tissues, health status, and sex	30
Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice	30
NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation	29
Role of sirtuins in bone biology: Potential implications for novel therapeutic strategies for osteoporosis	29
The inherited methylome landscape is directly altered with paternal aging and associated with offspring neurodevelopmental disorders	29
Mastering organismal aging through the endoplasmic reticulum proteostasis network	29
Late‐life exercise mitigates skeletal muscle epigenetic aging	29
Aging‐induced aberrant RAGE/PPARα axis promotes hepatic steatosis via dysfunctional mitochondrial β oxidation	29
A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan	29
Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single‐cell analysis	28
Glutathione peroxidase‐1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice	28
Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline	28
Platelet biomarkers for a descending cognitive function: A proteomic approach	28
Activation of angiotensin‐converting enzyme 2/angiotensin (1–7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling	28
Metabolipidomic profiling reveals an age‐related deficiency of skeletal muscle pro‐resolving mediators that contributes to maladaptive tissue remodeling	28
Plasma proteomic profile of frailty	27
Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice	27
NF‐κB/IKK activation by small extracellular vesicles within the SASP	27
Prevalent intron retention fine‐tunes gene expression and contributes to cellular senescence	27
Microbiota‐microglia connections in age‐related cognition decline	27
A decade of epigenetic change in aging twins: Genetic and environmental contributions to longitudinal DNA methylation	27
miR‐195 reduces age‐related blood–brain barrier leakage caused by thrombospondin‐1‐mediated selective autophagy	26
Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan	26
Autophagic receptor p62 protects against glycation‐derived toxicity and enhances viability	26
Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination	26
Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis	26
Lamin A safeguards the m⁶A methylase METTL14 nuclear speckle reservoir to prevent cellular senescence	26
The antagonistic pleiotropy of insulin‐like growth factor 1	26
Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals	26
Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD⁺ signaling	26
Youthful and age‐related matreotypes predict drugs promoting longevity	26
Role of sleep quality in the acceleration of biological aging and its potential for preventive interaction on air pollution insults: Findings from the UK Biobank cohort	25
Vitamin D supplementation worsens Alzheimer's progression: Animal model and human cohort studies	25
A germ cell‐specific ageing pattern in otherwise healthy men	25
Protein restriction and branched‐chain amino acid restriction promote geroprotective shifts in metabolism	25
Aging‐associated changes in CD47 arrangement and interaction with thrombospondin‐1 on red blood cells visualized by super‐resolution imaging	25
Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging	25
Monomeric C‐reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype‐dependent pattern: A risk factor for Alzheimer’s disease?	25
Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson‐Gilford Progeria syndrome	25
Adiponectin alleviated Alzheimer‐like pathologies via autophagy‐lysosomal activation	24
Shorter life and reduced fecundity can increase colony fitness in virtual Caenorhabditis elegans	24
Biological mechanisms of aging predict age‐related disease co‐occurrence in patients	24
Mechanisms by which autophagy regulates memory capacity in ageing	24
Activation of CREB‐mediated autophagy by thioperamide ameliorates β‐amyloid pathology and cognition in Alzheimer’s disease	24
Mitochondrial stress and mitokines in aging	24
Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging	24
Amyloid‐β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk‐AMPK pathway	24

Histone methyltransferase Smyd3 is a new regulator for vascular senescence	24
Cap‐independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α‐estradiol	23
The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence‐associated epigenomic remodeling	23
Transcriptional landscape of human microglia implicates age, sex, and APOE‐related immunometabolic pathway perturbations	23
Autophagy‐Sirt3 axis decelerates hematopoietic aging	23
Increased marrow adipogenesis does not contribute to age‐dependent appendicular bone loss in female mice	23
Altered glucocorticoid metabolism represents a feature of macroph‐aging	23
Dependence of PINK1 accumulation on mitochondrial redox system	23
Photobiomodulation suppresses JNK3 by activation of ERK/MKP7 to attenuate AMPA receptor endocytosis in Alzheimer's disease	22
The lysosomal proteome of senescent cells contributes to the senescence secretome	22
TRIM33 protects osteoblasts from oxidative stress‐induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation	22
Advanced Maternal Age‐associated SIRT1 Deficiency Compromises Trophoblast Epithelial−Mesenchymal Transition through an Increase in Vimentin Acetylation	22
Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma	21
AMPK‐mediated formation of stress granules is required for dietary restriction‐induced longevity in Caenorhabditis elegans	21
Advanced maternal age causes premature placental senescence and malformation via dysregulated α‐Klotho expression in trophoblasts	21
Aging impairs the essential contributions of non‐glial progenitors to neurorepair in the dorsal telencephalon of the Killifish Nothobranchius furzeri	21
Intraocular iron injection induces oxidative stress followed by elements of geographic atrophy and sympathetic ophthalmia	21
Human age reversal: Fact or fiction?	21
Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging	21
Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles	21
Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia	21
The SIRT6 activator MDL‐800 improves genomic stability and pluripotency of old murine‐derived iPS cells	21
Emerging rejuvenation strategies—Reducing the biological age	21
Regulation and roles of RNA modifications in aging‐related diseases	21
Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging	21
Delineating the relationship between immune system aging and myogenesis in muscle repair	21
Incomplete proline catabolism drives premature sperm aging	21
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition	20
Dysfunctional telomeres through mitostress‐induced cGAS/STING activation to aggravate immune senescence and viral pneumonia	20
Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue	20
Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin	20
Caenorhabditis elegans Lipin 1 moderates the lifespan‐shortening effects of dietary glucose by maintaining ω‐6 polyunsaturated fatty acids	20
Single‐oocyte transcriptome analysis reveals aging‐associated effects influenced by life stage and calorie restriction	20
NAMPT reduction‐induced NAD⁺ insufficiency contributes to the compromised oocyte quality from obese mice	20
The metabolome as a biomarker of aging in Drosophila melanogaster	20
Cell nonautonomous roles of NHR‐49 in promoting longevity and innate immunity	20
Progress and trends in the development of therapies for Hutchinson–Gilford progeria syndrome	20
Impaired phagocytic function in CX3CR1⁺ tissue‐resident skeletal muscle macrophages prevents muscle recovery after influenza A virus‐induced pneumonia in old mice	20
VPS35 D620N knockin mice recapitulate cardinal features of Parkinson’s disease	20
Cisd2 slows down liver aging and attenuates age‐related metabolic dysfunction in male mice	20
Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice	19
p300 arrests intervertebral disc degeneration by regulating the FOXO3/Sirt1/Wnt/β‐catenin axis	19
Contribution of proteases to the hallmarks of aging and to age‐related neurodegeneration	19
Altered sperm tsRNAs in aged male contribute to anxiety‐like behavior in offspring	19
The neuronal receptor tyrosine kinase Alk is a target for longevity	19
Sex‐specific accelerated decay in time/activity‐dependent plasticity and associative memory in an animal model of Alzheimer's disease	19
Total and regional body adiposity increases during menopause—evidence from a follow‐up study	19
Autophagy regulates the localization and degradation of p16^INK4a	19
Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age‐related neurodegeneration	19
Role of autophagy in aging: The good, the bad, and the ugly	19
Ouabain and chloroquine trigger senolysis of BRAF‐V600E‐induced senescent cells by targeting autophagy	19
microRNA‐146a controls age‐related bone loss	19
Geriatric fragility fractures are associated with a human skeletal stem cell defect	19
Lycorine hydrochloride suppresses stress‐induced premature cellular senescence by stabilizing the genome of human cells	19
Aging influences the cardiac macrophage phenotype and function during steady state and during inflammation	19
Comet assay for quantification of the increased DNA damage burden in primary human chondrocytes with aging and osteoarthritis	18
Identification of distinct and age‐dependent p16^High microglia subtypes	18
Stress induced aging in mouse eye	18
Metabolic dysfunction in human skin: Restoration of mitochondrial integrity and metabolic output by nicotinamide (niacinamide) in primary dermal fibroblasts from older aged donors	18
Age‐dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B	18
Genetic differences and longevity‐related phenotypes influence lifespan and lifespan variation in a sex‐specific manner in mice	18
CR reprograms acetyl‐CoA metabolism and induces long‐chain acyl‐CoA dehydrogenase and CrAT expression	18
Liver osteopontin is required to prevent the progression of age‐related nonalcoholic fatty liver disease	18
α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐ and aging‐related genes suggesting its implication in Parkinson's disease	18
Sirt1 overexpression improves senescence‐associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL‐11 transcription	18
Ganoderic acid D prevents oxidative stress‐induced senescence by targeting 14‐3‐3ε to activate CaM/CaMKII/NRF2 signaling pathway in mesenchymal stem cells	18
Chaperone‐mediated autophagy degrades Keap1 and promotes Nrf2‐mediated antioxidative response	18
Epigenetic quantification of immunosenescent CD8⁺ TEMRA cells in human blood	18
Elevated miR‐124‐3p in the aging colon disrupts mucus barrier and increases susceptibility to colitis by targeting T‐synthase	18
FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology	18
CXCL5‐CXCR2 signaling is a senescence‐associated secretory phenotype in preimplantation embryos	18
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ	18
Mitochondrial uncoupling protein‐2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age‐associated lung fibrosis	18
ZMAT3 hypomethylation contributes to early senescence of preadipocytes from healthy first‐degree relatives of type 2 diabetics	18
Inhibition of DNA methyltransferase aberrations reinstates antioxidant aging suppressors and ameliorates renal aging	17
Neuronal control of lipid metabolism by STR‐2 G protein‐coupled receptor promotes longevity in Caenorhabditis elegans	17
Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy	17
FOXO3a acts to suppress DNA double‐strand break‐induced mutations	17
Dioscin elevates lncRNA MANTIS in therapeutic angiogenesis for heart diseases	17
Role of Adiponectin‐Notch pathway in cognitive dysfunction associated with depression and in the therapeutic effect of physical exercise	17
MAPK15 protects from oxidative stress‐dependent cellular senescence by inducing the mitophagic process	17
Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function	17
Rapid senescence‐like response after acute injury	17
Attenuation of epigenetic regulator SMARCA4 and ERK‐ETS signaling suppresses aging‐related dopaminergic degeneration	17
A high‐fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the App^{NL−F/NL−F} knock‐in mouse model	17
Proper control of R‐loop homeostasis is required for maintenance of gene expression and neuronal function during aging	17
5‐HT6R null mutatrion induces synaptic and cognitive defects	17
Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock	17
DNA methylation signatures in Blood DNA of Hutchinson–Gilford Progeria syndrome	17
Sex differences in telomere length, lifespan, and embryonic dyskerin levels	17
Accelerated epigenetic aging in newborns with Down syndrome	17
Phosphoglycerate mutase family member 5 maintains oocyte quality via mitochondrial dynamic rearrangement during aging	17
Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM‐HET3 mice	17
Association between IGF‐1 levels ranges and all‐cause mortality: A meta‐analysis	17
FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16^INK4a increase	17