Aging Cell

Article	Citations
Lipid peroxidation products induce carbonyl stress, mitochondrial dysfunction, and cellular senescence in human and murine cells	252
Longitudinal analysis of physical function in older adults: The effects of physical inactivity and exercise training	175
Alpha‐ketoglutarate ameliorates age‐related and surgery induced temporomandibular joint osteoarthritis via regulating IKK/NF‐κB signaling	154
Advanced age and female sex protect cerebral arteries from mitochondrial depolarization and apoptosis during acute oxidative stress	149
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Aging Adipose‐Derived Mesenchymal Stem Cells, Cultured on a Native Young Extracellular Matrix, Are Protected From Senescence and Apoptosis Along With Increased Expression of HLA‐DR	100
Cooperative effects of SIRT1 and SIRT2 on APP acetylation	98
Increased levels of extracellular matrix proteins associated with extracellular vesicles from brains of aged mice	96
Expression of mitochondrial oxidative stress response genes in muscle is associated with mitochondrial respiration, physical performance, and muscle mass in the Study of Muscle, Mobility, and Aging	91
Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial	89
Long‐Term Stress Adaptation as a Highly‐Conserved Key Factor in Yeast Aging	87
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Diminished and Altered Cellular Senescence Response in Delayed Wound Healing of Aging	85
Serum‐Derived Extracellular Vesicles as Biological Indicator of Mobility Resilience in Older Adults	82
A p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo	81
Single‐Cell Profiling Reveals Distinct Immune Communication Networks in Centenarians and Elderly Controls	81
Correlates of life course physical activity in participants of the Baltimore longitudinal study of aging	77
Age‐dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging	71
Chronic TNF exposure induces glucocorticoid‐like immunosuppression in the alveolar macrophages of aged mice that enhances their susceptibility to pneumonia	70
SCARF2 is a target for chronic obstructive pulmonary disease: Evidence from multi‐omics research and cohort validation	69
Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain	65
The Roles of EDA2R in Ageing and Disease	63
Role of autophagy in aging: The good, the bad, and the ugly	62

Blood–brain barrier dysfunction promotes astrocyte senescence through albumin‐induced TGFβ signaling activation	61
Long‐term Tai Chi practice in older adults is associated with “younger” functional abilities	61
Nanocarriers for natural polyphenol senotherapeutics	61
Lactate Secretion by Monocytes as a Determinant of Innate Immune Cell Fitness in Healthy Elderly	60
Circadian regulation in aging: Implications for spaceflight and life on earth	60
Telomere Position Effect‐Over Long Distances Acts as a Genome‐Wide Epigenetic Regulator Through a Common Alu Element	59
Single Cell Sequencing Identifies Distinct Cellular Alterations in Impaired Aged and Diabetic Wounds	59
Telomere length and micronuclei trajectories in APP/PS1 mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic ma	58
Associations of combined accelerated biological aging and genetic susceptibility with incidence of heart failure in a population‐based cohort study	58
Compromised CD8+ T cell immunity in the aged brain increases severity of neurotropic coronavirus infection and postinfectious cognitive impairment	58
Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging	57
Silencing of the Metabolic Gene HKDC1 Is Associated With Aging and Neurodegeneration in Mice and Humans	56
Longitudinal Testing of Exploratory Behaviour in Mice Reveals Stable Cognitive Traits Across the Adult Lifespan	56
Inflammatory and immune markers in HIV ‐infected older adults on long‐term antiretroviral therapy: Persistent elevation of s	55
Biologically Younger Individuals, as Identified by MARK ‐ AGE Biological Age Scores, Display a Dis	55
Effects of Aging on Glucose and Lipid Metabolism in Mice	54
Cockayne syndrome B protein is implicated in transcription and associated chromatin dynamics in homeostatic and genotoxic conditions	53
Oral Citrate Supplementation Mitigates Age‐Associated Pathologic Intervertebral Disc Calcification in LG/J Mice	53
Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype	53
3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex	52
Dysregulated nicotinamide adenine dinucleotide metabolome in patients hospitalized with COVID‐19	52
Preliminary Evidence for Increased Histone Succinylation as a Potential Epigenetic Marker for Longevity	52
Intestinal stem cell aging at single‐cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics	51
Corrigendum to: Wnt/β‐catenin/ RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction	51
Anatomical Society Research Studentships 2023/24	50
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Alterations of lipid‐mediated mitophagy result in aging‐dependent sensorimotor defects	49
cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging	49
Reduced bone morphogenic protein signaling along the gut–neuron axis by heat shock factor promotes longevity	49
Local Growth Hormone Facilitates Aging of the Colon Epithelial Microenvironment	49
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Heterozygous OT‐I mice reveal that antigen‐specific CD8+ T cells shift from apoptotic to necrotic killers in the elderly	47
Ecological Realism Accelerates Epigenetic Aging in Mice	46
Correction to “Multiple Outcomes of the Germline p16 INK4a Mutation Affe	46
Hippocampal rejuvenation by a single intracerebral injection of one‐carbon metabolites in C57BL6 old wild‐type mice	46
Corrigendum to: Cap‐independent translation of GPLD1 enhances markers of brain health in long‐lived mutant and drug‐treated mice	46
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Differential Effects of Liver Regeneration on Aging‐Related Changes in Gene Expression and Metabolic Function	45
Organ‐Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming	45
Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis	43
The Aging Landscape by scRNAseq of Mesenchymal Lineage Cells in Mouse Bone	42
Young donor hematopoietic stem cells revitalize aged or damaged bone marrow niche by transdifferentiating into functional niche cells	42
The role of cardiac resident macrophage in cardiac aging	42
DNA methylation and chromatin accessibility predict age in the domestic dog	41
Deciphering the role of immune cell composition in epigenetic age acceleration: Insights from cell‐type deconvolution applied to human blood epigenetic clocks	41
Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species	41
Vitamin D 3 inhibits p38 MAPK	41
Age‐dependent aneuploidy in mammalian oocytes instigated at the second meiotic division	41
4‐phenylbutyric acid—Identity crisis; can it act as a translation inhibitor?	40

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery	40
CALB1 and RPL23 Are Essential for Maintaining Oocyte Quality and Function During Aging	40
Cellular senescence contributes to spontaneous repair of the rat meniscus	40
Discovery of genomic and transcriptomic pleiotropy between kidney function and soluble receptor for advanced glycation end products using correlated meta‐analyses: The Long Life Family Study	39
Targeting TGF‐β signaling, oxidative stress, and cellular senescence rescues osteoporosis in gerodermia osteodysplastica	38
Trends of genetic contributions on epigenetic clocks and related methylation sites with aging: A population‐based adult twin study	38
Aged Zebrafish as a Spontaneous Model of Cardiac Valvular Disease	38
The Immune Cell Atlas of “Longevity Molecular Tag”: Identification of Principal Immune Cell Subsets and Their Underlying Molecular Regulatory Mechanisms	37
Association between prescription drugs and all‐cause mortality risk in the UK population	37
Endothelial‐specific telomerase inactivation causes telomere‐independent cell senescence and multi‐organ dysfunction characteristic of aging	37
A Multi‐Organ Atlas Links Gut Microbial Metabolites to Systemic Redox Changes in Aging Mice	37
Lipoteichoic acid restrains macrophage senescence via β‐catenin/FOXO1/REDD1 pathway in age‐related osteoporosis	37
Multi‐Omics Analysis Reveals Photodynamic Therapy Ameliorating Skin Photoaging by Improving Cellular Senescence Through Mitohormesis‐Mediated Reduction of Citrate Content	37
Degradation of cochlear Connexin26 accelerate the development of age‐related hearing loss	37
Skeletal muscle DNA methylation: Effects of exercise and HIV	37
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Anatomical Society Research Studentships 2025/26	35
Canagliflozin Reprograms the Aging Hippocampus in Genetically Diverse UM ‐ HET 3 Mice and Attenuat	35
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Genetically determined blood pressure, antihypertensive drug classes, and frailty: A Mendelian randomization study	35
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Altered tubulin detyrosination due to SVBP malfunction induces cytokinesis failure and senescence, underlying a complex hereditary spastic paraplegia	35
Early resilience and epigenetic ageing: Results from the prospective Young Finns Study with a 31‐year follow‐up	34
High plasma concentrations of acyl‐coenzyme A binding protein (ACBP) predispose to cardiovascular disease: Evidence for a phylogenetically conserved proaging function of ACBP	33
Homocysteine potentiates amyloid β‐induced death receptor 4‐ and 5‐mediated cerebral endothelial cell apoptosis, blood brain barrier dysfunction and angiogenic impairment	33
Two weeks of exercise alters neuronal extracellular vesicle insulin signaling proteins and pro‐BDNF in older adults with prediabetes	33
Accelerated biological aging, healthy behaviors, and genetic susceptibility with incidence of stroke and its subtypes: A prospective cohort study	33
Age Deceleration and Reversal Gene Patterns in Dauer Diapause	33
Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions	33
Aging and cancer epigenetics: Where do the paths fork?	32
Vascular Endothelial NAMPT ‐Mediated NAD + Biosynthesis Regulates A	32
Pre‐Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine Responsiveness	32
Enhanced insulin‐regulated phagocytic activities support extreme health span and longevity in multiple populations	32
dVGLUT Is a Mediator of Sex Differences in Dopamine Neuron Mitochondrial Function Across Aging and in a Parkinson's Disease Model	32
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Form follows function: Nuclear morphology as a quantifiable predictor of cellular senescence	31
Senescence‐Driven IL ‐ 17A Inflammatory Circuit Promotes Epithelial–Mesenchymal Transition (	31
Chaperone‐mediated autophagy degrades Keap1 and promotes Nrf2‐mediated antioxidative response	31
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Overactivation of Cdc42 GTPase Impairs the Cytotoxic Function of NK Cells From Old Individuals Tow	31
AP‐1 is a regulatory transcription factor of inflammaging in the murine kidney and liver	31
Epigenetic age oscillates during the day	31
Cardiomyocyte Pdk4 response is associated with metabolic maladaptation in aging	31
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis	31
Peripheral inflammatory biomarkers are associated with cognitive function and dementia: Framingham Heart Study Offspring cohort	31
Associations of Skin Biomechanical Properties With Biological Aging Clocks and Longitudinal Changes in Intrinsic Capacity in Adults Aged 20–93: The INSPIRE‐T Project	30
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Graded Calorie Restriction Causes Graded Slowing of Epigenetic Ageing in Mice	30
Senescence detection using reflected light	30
The Redox Activity of Protein Disulphide Isomerase Functions in Non‐Homologous End‐Joining Repair to Prevent DNA Damage	30
APP Induces AICD ‐Mediated Autophagy‐Dependent Axon Degeneration	30
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miR ‐375‐3p/ STX6 Exacerbates Atherosclerosis by Promoting Endothelial Cell Senescence via Activation of	30
Telomerase modRNA Offers a Novel RNA ‐Based Approach to Treat Human Pulmonary Fibrosis	29
Intact mitochondrial function in the setting of telomere‐induced senescence	29
P2Y2 Inhibition Modifies the Anabolic Response to Exercise in Adult Mice	29
Glycation‐mediated tissue‐level remodeling of brain meningeal membrane by aging	29
Development of a Short Telomere Zebrafish Model for Accelerated Aging Research and Antiaging Drug Screening	29
Downregulation of PLIN2 in human dermal fibroblasts impairs mitochondrial function in an age‐dependent fashion and induces cell senescence via GDF15	29
PCBP2 Regulates p16 INK4a ‐Dependent Cell	29
LEMD2‐associated progeroid syndrome: Expanding the phenotype of the nuclear envelopathy caused by a defect in LEMD2 gene	29
Cochlear Neurotrophin‐3 overexpression at mid‐life prevents age‐related inner hair cell synaptopathy and slows age‐related hearing loss	28
Delayed formation of neural representations of space in aged mice	28
Targeted sequencing of the 9p21.3 region reveals association with reduced disease risks in Ashkenazi Jewish centenarians	28
Fkbp5 gene deletion: Circadian rhythm profile and brain proteomics in aged mice	28
Age‐Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light‐Induced Outer Retinal Degeneration in Mice	28
In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation	27
Senescence Alters Antimicrobial Peptide Expression and Induces Amyloid‐β Production in Retinal Pigment Epithelial Cells	27
Single‐cell RNA sequencing reveals the CRTAC1+ population actively contributes to the pathogenesis of spinal ligament degeneration by SPP1+ macro	27
Proteo‐metabolomic insights for early dual physical and cognitive impairments: A search for biomarkers of healthy aging based on muscle–brain crosstalk	27
Exerkine FNDC5/irisin‐enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin‐1	26
RUVBL2 Regulates Microglia Metabolic Reprogramming to Mediate Stress Granules Aggregation Exacerbating Postoperative Delirium in Aged Mild Cognitive Impairment Rats	26
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Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal‐dominant Alzheimer's disease	26
Myeloid ectopic viral integration site 2 accelerates the progression of Alzheimer's disease	26
T‐CLASS: An Online Tool for the Identification and Classification of Aging and Senescence Using Transcriptome Data	26
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Intermittent Fasting Enhances Motor Coordination Through Myelin Preservation in Aged Mice	26

The cellular bases of mobility from the Study of Muscle, Mobility and Aging (SOMMA)	26
Network‐based cytokine inference implicates Oncostatin M as a driver of an inflammation phenotype in knee osteoarthritis	26
B cell‐intrinsic changes with age do not impact antibody‐secreting cell formation but delay B cell participation in the germinal centre reaction	26
Muscle Cathepsin B Treatment Improves Behavioral and Neurogenic Deficits in a Mouse Model of Alzheimer's Disease	26
Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice	26
DeepQA: A Unified Transcriptome‐Based Aging Clock Using Deep Neural Networks	26
Ketogenic β‐hydroxybutyrate regulates β‐hydroxybutyrylation of TCA cycle‐associated enzymes and attenuates disease‐associated pathologies in Alzheimer's mice	26
DP1 Receptor Blockade Attenuates Microglial Senescence and Cognitive Decline Caused by PTGDS in Exosomes From Aged Brains	26
Proteomic Signatures of Epigenetic Age in African Green Monkey Cerebrospinal Fluid and Plasma	25
Exploring Lymph Node Stroma Ageing: Immune Implications and Future Directions	25
NMR metabolomic modeling of age and lifespan: A multicohort analysis	25
p62/ SQSTM1 Condensation Modulates Mitochondrial Clustering to Participate in Mitochondrial Quality Control	25
Phosphodiesterase‐5 Inhibition and Alzheimer's Disease Risk: A Mendelian Randomisation Study	25
Contextualizing aging clocks and properly describing biological age	25
Stiffening symphony of aging: Biophysical changes in senescent osteocytes	25
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Isolating the direct effects of growth hormone on lifespan and metabolism in mice	25
Novel PMVs / ZIP4 /Zinc/Prelamin A Axis Promotes Nuclear Dysmorphism and Vascular Aging in Humans	25
Ghrelin delays premature aging in Hutchinson‐Gilford progeria syndrome	25
Proteomic analysis across aged tissues reveals distinct signatures and the crucial involvement of midgut barrier function in the regulation of aging	24
Age‐related memory vulnerability to interfering stimuli is caused by gradual loss of MAPK‐dependent protection in Drosophila	24
A novel framework to build saliva‐based DNA methylation biomarkers: Quantifying systemic chronic inflammation as a case study	24
Age‐related thymic involution: Mechanisms and functional impact	24
Age‐ and disease‐related autophagy impairment in Huntington disease: New insights from direct neuronal reprogramming	24
Telomerase reverse transcriptase gene knock‐in unleashes enhanced longevity and accelerated damage repair in mice	24
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Age‐dependent NMDA receptor function is regulated by the amyloid precursor protein	24
Sirt1 overexpression improves senescence‐associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL‐11 transcription	24
circSIRT2/miR‐542‐3p/VASH1 axis regulates endothelial‐to‐mesenchymal transition (EndMT) in subretinal fibrosis in age‐related macular degeneration models	24
Cerebral Metabolic Rate of Oxygen and Accelerometry‐Based Fatigability in Community‐Dwelling Older Adults	24
YTHDC1 Orchestrates Telomerase Assembly via Scaffold‐Mediated TERT ‐ TERC	24
Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma	24
Smoking Promotes AT2 Cell Senescence and Exacerbates Pulmonary Fibrosis by Downregulating POT1 via Integratively Inducing CpG Methylation and MECP2‐Mediated	24
Pro‐inflammatory cytokine 11 plays a pivotal role in inflammaging‐associated pathologies	23
A novel senolytic drug for pulmonary fibrosis: BTSA1 targets apoptosis of senescent myofibroblasts by activating BAX	23
Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4‐induced brain pathology	23
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Aβ ‐induced excessive mitochondrial fission drives type H blood vessels injury to aggravate bone loss in APP/PS1 mice with Alzheimer's diseases	23
SQSTM1 /p62 Orchestrates Skin Aging via USP7 Degradation	23
Large‐scale genetic screens identify BET‐1 as a cytoskeleton regulator promoting actin function and life span	23
Morphological phenotyping of the aging cochlea in inbred C57BL/6N and outbred CD1 mouse strains	23
Correction to ‘Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single‐cell ana	23
Fusion and expansion of vitellogenin vesicles during Caenorhabditis elegans intestinal senescence	23
Anatomical Society Research Studentships 2025/26	23
Mechanistic Insights Into 5′‐ tiRNA ‐His‐ GTG Mediated Activation of the	23
Whole‐genome methylation analysis of aging human tissues identifies age‐related changes in developmental and neurological pathways	23
Aging‐associated decrease of PGC‐1α promotes pain chronification	23
Senolytic‐Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers	23
Not Aging but Calorie Restriction Strongly Affects Protein Oxidation in Heart and Brain Mitochondria	23
MskAge —An Epigenetic Biomarker of Musculoskeletal Age Derived From a Genetic Algorithm Islands Model	23
MSC ‐Derived Exosomal lnc‐AGT‐3 : A Novel Anti‐Angiogenic Target in Age‐Related Macular Degeneration Through	23
Macrophage Subpopulation Promotes Skeletal Muscle Regeneration Through HGF/MET Signaling‐Mediated Skeletal Muscle Stem Cell Proliferation	23
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Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence	23
TSP50 in Neural Stem Cells Regulates Aging‐Related Cognitive Decline and Neuroinflammation by Altering the Gut Microbiota	23
Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage	23
DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment	23
Effect of canakinumab on frailty: A post hoc analysis of the CANTOS trial	23
Plasma proteomic signature of decline in gait speed and grip strength	22
Accelerated replicative senescence of ataxia‐telangiectasia skin fibroblasts is retained at physiologic oxygen levels, with unique and common transcriptional patterns	22
Dual treatment with kynurenine pathway inhibitors and NAD + precursors synergistically extends life span in	22
Aging clock based on nucleosome reorganisation derived from cell‐free DNA	22
Age‐related increase of CD38 directs osteoclastogenic potential of monocytic myeloid‐derived suppressor cells through mitochondrial dysfunction in male mice	22
Senescent Macrophages Promote Age‐Related Revascularization Impairment by Increasing Antiangiogenic VEGF ‐ A165B	22
Prepubertal castration eliminates sex differences in lifespan and growth trajectories in genetically heterogeneous mice	22
Age‐dependent loss of hepatic SIRT1 enhances NLRP3 inflammasome signaling and impairs capacity for liver fibrosis resolution	22
Comparative single‐cell transcriptomic analysis across tissues of aging primates reveals specific autologous activation of ZNF281 to mitigate oxidative stress in cornea	21
Autophagy‐Independent Function of ATG‐18 Is Essential for Gonadal Longevity in Caenorhabditis elegans	21
An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease	21
The SATB1‐MIR22‐GBA axis mediates glucocerebroside accumulation inducing a cellular senescence‐like phenotype in dopaminergic neurons	21
The lysosomal proteome of senescent cells contributes to the senescence secretome	21
Bone dysplasia in Hutchinson‐Gilford progeria syndrome is associated with dysregulated differentiation and function of bone cell populations	21
Entropy, Assessed by Homeostatic Dysregulation on Electrocardiograms Predicts Fracture and Mortality	21
Brain Aging Mediating Heart Imaging‐Derived Phenotypes and Mental and Nervous System Disorders	21
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ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds	21
Differential Gene Expression in Human Hippocampus With Aging	21
Optimising Age‐Specific Insulin Signalling to Slow Down Reproductive Ageing Increases Fitness in Different Nutritional Environments	21
Proteomic aging clock ( PAC ) predicts age‐related outcomes in middle‐aged and older adults	21
Hungry for biomarkers of aging	21
Nicotinamide riboside intervention alleviates hematopoietic system injury of ionizing radiation‐induced premature aging mice	21
TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1	20
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Systemic LINE ‐1 RNA in Plasma Extracellular Vesicles Drives Neuroinflammation and Cognitive Dysfu	20
Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence	20
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Associations between skeletal muscle energetics and accelerometry‐based performance fatigability: Study of Muscle, Mobility and Aging	20
Microbiological Foundations to Optimise Intrinsic Capacity and Promote Healthy Ageing: An Integration Into the Life Course Approach	20
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Plasma Proteomic Signature as a Predictor of Age Advancement in People Living With HIV	19