Aging Cell

Article	Citations
Latent transforming growth factor beta binding protein 4: A regulator of mitochondrial function in acute kidney injury	181
Deletion of quinolinate phosphoribosyltransferase gene accelerates frailty phenotypes and neuromuscular decline with aging in a sex‐specific pattern	127
Lifetime age‐related changes in clinical laboratory results, aging clocks and mortality predictors in 2412 Golden Retrievers	118
seRNA PAM controls skeletal muscle satellite cell proliferation and aging through trans regulation of Timp2 expression synergistically with Ddx5	117
Circular RNA Telomerase Reverses Endothelial Senescence in Progeria	113
Effects of the VIVIFRAIL Exercise Protocol on Circulatory and Intracellular Peripheral Mediators Bridging Mitochondrial Dynamics and Inflammation in Robust and Frail Older People	113
Compromised CD8+ T cell immunity in the aged brain increases severity of neurotropic coronavirus infection and postinfectious cognitive impairment	108
Knockdown of RUVBL2 improves hnRNPA2/B1‐stress granules dynamics to inhibit perioperative neurocognitive disorders in aged mild cognitive impairment rats	98
Metabolomic characterization of unintentional weight loss among community‐dwelling older Black and White men and women	96
The Ercc1−/Δ mouse model of XFE progeroid syndrome undergoes accelerated retinal degeneration	94
Accumulation of senescent cells in the adrenal gland induces hypersecretion of corticosterone via IL1β secretion	92
Non‐enzymatic function of WRN RECQL helicase regulates removal of topoisomerase‐I‐DNA covalent complexes and triggers NF‐κB signaling in cancer	89
Genetic context drives age‐related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits	85
Epigenetic clock and methylation studies in elephants	80
Telomere length and micronuclei trajectories in APP/PS1 mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic ma	75
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Asparagine prevents intestinal stem cell aging via the autophagy‐lysosomal pathway	74
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CAV1 Exacerbates Renal Tubular Epithelial Cell Senescence by Suppressing CaMKK2/AMPK‐Mediated Autophagy	63
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Sensitivity of the S1 neuronal calcium network to insulin and Bay‐K 8644 in vivo: Relationship to gait, motivation, and aging processes	57
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Proteomes of primary skin fibroblasts from healthy individuals reveal altered cell responses across the life span	55
microRNA‐425 loss mediates amyloid plaque microenvironment heterogeneity and promotes neurodegenerative pathologies	55
Oculopharyngeal muscular dystrophy mutations link the RNA‐binding protein HNRNPQ to autophagosome biogenesis	55
Acyl coenzyme A binding protein (ACBP): An aging‐ and disease‐relevant “autophagy checkpoint”	55
Single‐worm quantitative proteomics reveals aging heterogeneity in isogenic Caenorhabditis elegans	54
Sexual dimorphism in the peripheral metabolic homeostasis and behavior in the TgF344‐AD rat model of Alzheimer's disease	53
Chronic TNF exposure induces glucocorticoid‐like immunosuppression in the alveolar macrophages of aged mice that enhances their susceptibility to pneumonia	53
Biomarkers of cellular senescence and risk of death in humans	53
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CCR4‐NOT subunit CCF‐1/CNOT7 promotes transcriptional activation to multiple stress responses in Caenorhabditis elegans	52
Müller Glia maintain their regenerative potential despite degeneration in the aged zebrafish retina	50
Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice	50
Announcement	48
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Methylation entropy landscape of Chinese long‐lived individuals reveals lower epigenetic noise related to human healthy aging	45
Centenarian hippocampus displays high levels of astrocytic metallothioneins	45
Can statin preventative treatment inform geroscience‐guided therapeutics?	44
Age‐ and sex‐dependent alterations in primary somatosensory cortex neuronal calcium network dynamics during locomotion	44
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Impact of diffused versus vasculature targeted DNA damage on the heart of mice depleted of telomeric factor Ft1	43
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Long‐term Tai Chi practice in older adults is associated with “younger” functional abilities	40
Biomarker development for translational geroscience: Considerations for a strategic framework focusing on early clinical development	39
Overexpression of mitochondrial fission or mitochondrial fusion genes enhances resilience and extends longevity	39
Proteomic architecture of frailty across the spectrum of cardiovascular disease	39
Progeria‐based vascular model identifies networks associated with cardiovascular aging and disease	39
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Role of autophagy in aging: The good, the bad, and the ugly	38
A short peptide protects from age‐onset proteotoxicity	38
The “telomereless” erythrocytes and telomere‐length dependent erythropoiesis	37
Region‐based epigenetic clock design improves RRBS‐based age prediction	36
Ectopic cervical thymi and no thymic involution until midlife in naked mole rats	36
Viral uptake and pathophysiology of the lung endothelial cells in age‐associated severe SARS‐CoV‐2 infection models	36
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Effects of cerebral amyloid angiopathy on the brain vasculome	36
Endosomal trafficking protein TBC‐2 modulates stress resistance and lifespan through DAF‐16‐dependent and independent mechanisms	36
Platelet biomarkers identifying mild cognitive impairment in type 2 diabetes patients	35
STAT3 promotes a youthful epigenetic state in articular chondrocytes	35
Associations between skeletal muscle energetics and accelerometry‐based performance fatigability: Study of Muscle, Mobility and Aging	35
Aging influences the cardiac macrophage phenotype and function during steady state and during inflammation	35

Biological mechanisms of aging predict age‐related disease co‐occurrence in patients	35
Long term methionine restriction: Influence on gut microbiome and metabolic characteristics	35
Diet composition, adherence to calorie restriction, and cardiometabolic disease risk modification	35
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Transcriptomics age acceleration in prolonged treated HIV infection	34
Sex and age differences in AMPK phosphorylation, mitochondrial homeostasis, and inflammation in hearts from inflammatory cardiomyopathy patients	34
Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease	34
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Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy‐like retinal degeneration in a mouse model with iron overload	34
Advanced age and female sex protect cerebral arteries from mitochondrial depolarization and apoptosis during acute oxidative stress	34
Plasma Proteomic Signature as a Predictor of Age Advancement in People Living With HIV	33
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Reproductive‐Triggered Sterol Competition Exacerbates Age‐Related Intestinal Barrier Damage in Drosophila Females	32
A comprehensive AI‐driven analysis of large‐scale omic datasets reveals novel dual‐purpose targets for the treatment of cancer and aging	32
Cellular Senescence Contributes to the Dysfunction of Tight Junctions in Submandibular Glands of Aging Mice	32
Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments	32
Heterochromatic silencing of immune‐related genes in glia is required for BBB integrity and normal lifespan in drosophila	32
Unraveling Alveolar Fibroblast and Activated Myofibroblast Heterogeneity and Differentiation Trajectories During Lung Fibrosis Development and Resolution in Young and Old Mice	32
Oral Citrate Supplementation Mitigates Age‐Associated Pathologic Intervertebral Disc Calcification in LG/J Mice	32
Negative Effect of Gst‐35 on the Health Span of Caenorhabditis elegans Through Lysosomal Dysfunction via the Pmk‐1 and Skr Genes	32
Correlates of life course physical activity in participants of the Baltimore longitudinal study of aging	31
Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer’s disease	31
Cooperative effects of SIRT1 and SIRT2 on APP acetylation	31
Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy	30
Increased levels of extracellular matrix proteins associated with extracellular vesicles from brains of aged mice	30
Associations of age and sex with characteristics of extracellular vesicles and protein‐enriched fractions of blood plasma	30
Lipid peroxidation products induce carbonyl stress, mitochondrial dysfunction, and cellular senescence in human and murine cells	30
2'‐Fucosyllactose attenuates aging‐related metabolic disorders through modulating gut microbiome‐T cell axis	29
Mitochondrial stress and mitokines in aging	29
Piwi mutant germ cells transmit a form of heritable stress that promotes longevity	29
Telomere Position Effect‐Over Long Distances Acts as a Genome‐Wide Epigenetic Regulator Through a Common Alu Element	29
Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians	29
Oocyte aging is controlled by mitogen‐activated protein kinase signaling	28
Modelling the dynamics of senescence spread	28
Enhanced NRF2 expression mitigates the decline in neural stem cell function during aging	28
Reduced endosomal microautophagy activity in aging associates with enhanced exocyst‐mediated protein secretion	28
Type I IFN stimulates lymph node stromal cells from adult and old mice during a West Nile virus infection	28
Integrative analysis of clinical and epigenetic biomarkers of mortality	28
Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice	28
Effects of Aging on Glucose and Lipid Metabolism in Mice	28
Deficiency for scavenger receptors Stabilin‐1 and Stabilin‐2 leads to age‐dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice	27
Late‐life plasma proteins associated with prevalent and incident frailty: A proteomic analysis	27
A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan	27
IL‐21‐IgFc immunotherapy alters transcriptional landscape of lymph node cells leading to enhanced flu vaccine response in aging and SIV infection	27
The association between chrononutrition behaviors and muscle health among older adults: The study of muscle, mobility and aging	27
Exaggerated hypoxic vascular breakdown in aged brain due to reduced microglial vasculo‐protection	27
Glucagon‐like peptide‐1 receptor agonists to expand the healthy lifespan: Current and future potentials	27
Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging	27
GM‐CSF and IL‐7 fusion cytokine engineered tumor vaccine generates long‐term Th‐17 memory cells and increases overall survival in aged syngeneic mouse models of glioblastoma	27
Expression of mitochondrial oxidative stress response genes in muscle is associated with mitochondrial respiration, physical performance, and muscle mass in the Study of Muscle, Mobility, and Aging	26
TAF15 downregulation contributes to the benefits of physical training on dendritic spines and working memory in aged mice	26
The E262K mutation in Lamin A links nuclear proteostasis imbalance to laminopathy‐associated premature aging	26
Long‐term demyelination and aging‐associated changes in mice corpus callosum; evidence for the role of accelerated aging in remyelination failure in a mouse model of multiple sclerosis	26
Nanocarriers for natural polyphenol senotherapeutics	26
Alpha‐ketoglutarate ameliorates age‐related and surgery induced temporomandibular joint osteoarthritis via regulating IKK/NF‐κB signaling	26
Metformin treatment results in distinctive skeletal muscle mitochondrial remodeling in rats with different intrinsic aerobic capacities	26
Rejuvenation of neutrophils and their extracellular vesicles is associated with enhanced aged fracture healing	26
Tgm2‐Catalyzed Covalent Cross‐Linking of IκBα Drives NF‐κB Nuclear Translocation to Promote SASP in Senescent Microglia	25
Circadian regulation in aging: Implications for spaceflight and life on earth	25
Rapamycin/metformin co‐treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice	25
TRIM33 protects osteoblasts from oxidative stress‐induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation	25
Disrupted macrophage metabolic reprogramming in aged soleus muscle during early recovery following disuse atrophy	25
Canonical and extra‐telomeric functions of telomerase: Implications for healthy ageing conferred by endurance training	25
Dietary cinnamon promotes longevity and extends healthspan via mTORC1 and autophagy signaling	25
Dysregulated glial genes in Alzheimer's disease are essential for homeostatic plasticity: Evidence from integrative epigenetic and single cell analyses	25
Age‐dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging	25
A rationally designed fluorescence probe achieves highly specific and long‐term detection of senescence in vitro and in vivo	24
Unveiling ceramide dynamics: Shedding light on healthy aging in growth hormone‐releasing hormone knockout mice	24
The D3‐creatine dilution method non‐invasively measures muscle mass in mice	24
Measuring biological age using a functionally interpretable multi‐tissue RNA clock	24
Age patterns of intra‐pair DNA methylation discordance in twins: Sex difference in epigenomic instability and implication on survival	24
Erratum to: Increased miR‐34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS‐JNK‐p53 pathway in Alzheimer's disease	24
Corrigendum: Body weight and high‐fat diet are associated with epigenetic aging in female members of the BXD murine family	24
Hematopoietic progenitor cell liabilities and alarmins S100A8/A9‐related inflammaging associate with frailty and predict poor cardiovascular outcomes in older adults	24
Role of Adiponectin‐Notch pathway in cognitive dysfunction associated with depression and in the therapeutic effect of physical exercise	24
The ultrastructural and proteomic analysis of mitochondria‐associated endoplasmic reticulum membrane in the midbrain of a Parkinson's disease mouse model	24
DNA repair‐deficient premature aging models display accelerated epigenetic age	23
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The longevity factor spermidine is part of a highly heritable complex erythrocyte phenotype associated with longevity	23
LEF1 isoforms regulate cellular senescence and aging	23

Associations of combined accelerated biological aging and genetic susceptibility with incidence of heart failure in a population‐based cohort study	23
A p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo	23
Calorie restriction reduces biomarkers of cellular senescence in humans	23
Chronic β3‐AR stimulation activates distinct thermogenic mechanisms in brown and white adipose tissue and improves systemic metabolism in aged mice	23
Glycogen phosphorylase inhibition improves cognitive function of aged mice	23
Nitric oxide‐soluble guanylyl cyclase pathway as a contributor to age‐related memory impairment in Drosophila	22
Blood–brain barrier dysfunction promotes astrocyte senescence through albumin‐induced TGFβ signaling activation	22
Circulating miR‐19a‐3p and miR‐19b‐3p characterize the human aging process and their isomiRs associate with healthy status at extreme ages	22
Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain	22
Platelet response to influenza vaccination reflects effects of aging	22
Decreased Enterobacteriaceae translocation due to gut microbiota remodeling mediates the alleviation of premature aging by a high‐fat diet	22
Longitudinal analysis of physical function in older adults: The effects of physical inactivity and exercise training	21
Diurnal expression of Dgat2 induced by time‐restricted feeding maintains cardiac health in the Drosophila model of circadian disruption	21
S‐adenosyl‐L‐homocysteine extends lifespan through methionine restriction effects	21
Nucleoporin93 limits Yap activity to prevent endothelial cell senescence	21
SCARF2 is a target for chronic obstructive pulmonary disease: Evidence from multi‐omics research and cohort validation	21
Large‐Scale metabolomics: Predicting biological age using 10,133 routine untargeted LC–MS measurements	21
Age‐related changes in metabolites in young donor livers and old recipient sera after liver transplantation from young to old rats	21
Organelle dysfunction upon asrij depletion causes aging‐like changes in mouse hematopoietic stem cells	21
Exercise enhancement by RGS14 disruption is mediated by brown adipose tissue	21
Loss of heterochromatin and retrotransposon silencing as determinants in oocyte aging	20
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming	20
Myeloid cell‐specific mutation of Spi1 selectively reduces M2‐biased macrophage numbers in skeletal muscle, reduces age‐related muscle fibrosis and prevents sarcopenia	20
Abalone peptide increases stress resilience and cost‐free longevity via SKN‐1‐governed transcriptional metabolic reprogramming in C. elegans	20
Inflammatory and immune markers in HIV‐infected older adults on long‐term antiretroviral therapy: Persistent elevation of sCD14 and of proinflammatory effector memory T cells	20
System‐level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity	20
Cisd2 slows down liver aging and attenuates age‐related metabolic dysfunction in male mice	20
Alzheimer’s disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR‐edited human neuronal cells	20
Platelet biomarkers for a descending cognitive function: A proteomic approach	20
Endothelial cell‐specific reduction in mTOR ameliorates age‐related arterial and metabolic dysfunction	19
Telomere length and metabolic syndrome traits: A Mendelian randomisation study	19
Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans	19
Chronic polypharmacy, monotherapy, and deprescribing: Understanding complex effects on the hepatic proteome of aging mice	19
Chromosome‐level Asian elephant genome assembly and comparative genomics of long‐lived mammals reveal the common substitutions for cancer resistance	19
Reducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription	19
RETRACTION: 1,25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling	19
Plasma proteomic signature of human longevity	19
Importance of Bmal1 in Alzheimer's disease and associated aging‐related diseases: Mechanisms and interventions	19
Arginine metabolism is a biomarker of red blood cell and human aging	19
Microbiota‐microglia connections in age‐related cognition decline	19
NF‐κB/IKK activation by small extracellular vesicles within the SASP	19
Mendelian randomization supports causality between overweight status and accelerated aging	19
miR‐24 and its target gene Prdx6 regulate viability and senescence of myogenic progenitors during aging	18
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The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress	18
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4‐phenylbutyric acid—Identity crisis; can it act as a translation inhibitor?	18
DNA methylation and chromatin accessibility predict age in the domestic dog	18
The conserved microRNA‐229 family controls low‐insulin signaling and dietary restriction induced longevity through interactions with SKN‐1/NRF2	18
B cell senescence promotes age‐related changes in oral microbiota	18
Soluble guanylate cyclase activator BAY 54–6544 improves vasomotor function and survival in an accelerated ageing mouse model	18
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Rapid and synchronous chemical induction of replicative‐like senescence via a small molecule inhibitor	18
Targeting TGF‐β signaling, oxidative stress, and cellular senescence rescues osteoporosis in gerodermia osteodysplastica	17
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Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents	17
A small‐molecule screen identifies novel aging modulators by targeting 5‐HT/DA signaling pathway	17
Proteasome Augmentation Mitigates Age‐Related Cognitive Decline in Mice	17
Dysregulated nicotinamide adenine dinucleotide metabolome in patients hospitalized with COVID‐19	17
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Long‐term exposure to excessive norepinephrine in the brain induces tau aggregation, neuronal death, and cognitive deficits in early tau transgenic mice	17
A Single‐Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging	17
Pathogenic TDP‐43 accelerates the generation of toxic exon1 HTT in Huntington's disease knock‐in mice	17
Phosphodiesterase inhibitor ameliorates senescent changes of renal interstitial pericytes in aging kidney	17
Young transgenic hMTH1 mice are protected against dietary fat‐induced metabolic stress—implications for enhanced longevity	17
Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan	17
Trends of genetic contributions on epigenetic clocks and related methylation sites with aging: A population‐based adult twin study	17
Young donor hematopoietic stem cells revitalize aged or damaged bone marrow niche by transdifferentiating into functional niche cells	17
miR‐203‐3p promotes senescence of mouse bone marrow mesenchymal stem cells via downregulation of Pbk	16
Cockayne syndrome B protein is implicated in transcription and associated chromatin dynamics in homeostatic and genotoxic conditions	16
Molecular and physiological mechanisms of aging are distinct in the cardiac right and left ventricles	16
Hippocampal rejuvenation by a single intracerebral injection of one‐carbon metabolites in C57BL6 old wild‐type mice	16
Anatomical Society Research Studentships 2023/24	16
Dysregulation of choline metabolism and therapeutic potential of citicoline in Huntington's disease	16
Rejuvenation of Senescent Cells, In Vitro and In Vivo, by Low‐Frequency Ultrasound	16
Hippocampal Nogo66‐NgR1 signaling activation restricts postsynaptic assembly in aged mice with postoperative neurocognitive disorders	16
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The Effect of Advancing Age and Intraocular Pressure Injury on Retinal Ganglion Cell Function and Synaptic Connectivity	16
Temporal Changes in Alzheimer's Disease‐Related Biomarkers in the CSF of Cognitively Normal Subjects at Different Ages: The Chongqing Ageing and Dementia Study	16
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DNA fork remodeling proteins, Zranb3 and Smarcal1, are uniquely essential for aging hematopoiesis	16
Impaired mitophagosome–lysosome fusion mediates olanzapine‐induced aging	16
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Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan	16
Associations Between Leisure‐Time Physical Activity and Metabolomics‐Based Markers of Biological Aging in Late Midlife: Short‐Term and Long‐Term Follow‐Up	16
Bloom syndrome patients and mice display accelerated epigenetic aging	16
Age‐related changes to macrophage subpopulations and TREM2 dysregulation characterize attenuated fracture healing in old mice	15
SIRT6 deficiency causes ovarian hypoplasia by affecting Plod1‐related collagen formation	15
The physiologic complexity of beat‐to‐beat blood pressure is associated with age‐related alterations in blood pressure regulation	15
Prophylactic senolytic treatment in aged mice reduces seizure severity and improves survival from Status Epilepticus	15
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Identification of nicotinamide N‐methyltransferase as a promising therapeutic target for sarcopenia	15
Transcriptomic and intervention evidence reveals domestic dogs as a promising model for anti‐inflammatory investigation	15