Neoplasia

Article	Citations
UALCAN: An update to the integrated cancer data analysis platform	676
ONC201 and imipridones: Anti-cancer compounds with clinical efficacy	84
Development and prevalence of castration-resistant prostate cancer subtypes	65
ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma	63
Pamiparib is a potent and selective PARP inhibitor with unique potential for the treatment of brain tumor	59
Glycolysis-induced drug resistance in tumors—A response to danger signals?	53
A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo	43
STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications	43
Exosomal lncRNA NEAT1 from cancer-associated fibroblasts facilitates endometrial cancer progression via miR-26a/b-5p-mediated STAT3/YKL-40 signaling pathway	42
The forces driving cancer extracellular vesicle secretion	41
SalvGlandDx – a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets	40
Evaluating patient-specific neoadjuvant regimens for breast cancer via a mathematical model constrained by quantitative magnetic resonance imaging data	40
Tumor necrosis factor in lung cancer: Complex roles in biology and resistance to treatment	37
Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses	34
Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine	32
Trop‐2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis	32
MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking	32
MKL1/miR-5100/CAAP1 loop regulates autophagy and apoptosis in gastric cancer cells	32
Predicting patient-specific response to adaptive therapy in metastatic castration-resistant prostate cancer using prostate-specific antigen dynamics	31
TRIM11 promotes breast cancer cell proliferation by stabilizing estrogen receptor α	31
Rosmarinic acid represses colitis-associated colon cancer: A pivotal involvement of the TLR4-mediated NF-κB-STAT3 axis	30
Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping	30
Prostate cancer-derived MMP-3 controls intrinsic cell growth and extrinsic angiogenesis	30
Short chain fatty acids delay the development of hepatocellular carcinoma in HBx transgenic mice	29
Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells	27

Opioids drive breast cancer metastasis through the δ-opioid receptor and oncogenic STAT3	26
Bone marrow mesenchymal stem cells interact with head and neck squamous cell carcinoma cells to promote cancer progression and drug resistance	24
EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG	24
Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer	22
Spatiotemporal trends of the global burden of melanoma in 204 countries and territories from 1990 to 2019: Results from the 2019 global burden of disease study	22
Myeloid-derived suppressor cells promote tumor growth and sorafenib resistance by inducing FGF1 upregulation and fibrosis	22
Cholesterol and saturated fatty acids synergistically promote the malignant progression of prostate cancer	22
LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase	21
Targeting AGTR1/NF-κB/CXCR4 axis by miR-155 attenuates oncogenesis in glioblastoma	21
Copy number variation in triple negative breast cancer samples associated with lymph node metastasis	21
An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis	21
The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science	21
Ultrasound-mediated disruption of the blood tumor barrier for improved therapeutic delivery	20
Estrogen-induced hypomethylation and overexpression of YAP1 facilitate breast cancer cell growth and survival	20
mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics	20
Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut	19
Noninvasive multiparametric characterization of mammary tumors with transmission-reflection optoacoustic ultrasound	19
Enterococcus faecalis promotes a migratory and invasive phenotype in colon cancer cells	19
A systemic review of the role of enterotoxic Bacteroides fragilis in colorectal cancer	19
Discovery of a new inhibitor targeting PD-L1 for cancer immunotherapy	19
Hepatocellular carcinoma in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis	18
Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin	18
Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes	18
Molecular and genetic biomarkers implemented from next-generation sequencing provide treatment insights in clinical practice for Waldenström macroglobulinemia	18
Liver fluke granulin promotes extracellular vesicle-mediated crosstalk and cellular microenvironment conducive to cholangiocarcinoma	17
Composition of gastrointestinal microbiota in association with treatment response in individuals with metastatic castrate resistant prostate cancer progressing on enzalutamide and initiating treatment	17
Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4	17
PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1	16
Hypoxia induces docetaxel resistance in triple-negative breast cancer via the HIF-1α/miR-494/Survivin signaling pathway	16
High expression of SCHLAP1 in primary prostate cancer is an independent predictor of biochemical recurrence, despite substantial heterogeneity	15
P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9	15
Mathematical modeling of radiotherapy and its impact on tumor interactions with the immune system	15
Abscisic acid regulates dormancy of prostate cancer disseminated tumor cells in the bone marrow	15
CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation	15
Synergistic effect of Chloroquine and Panobinostat in ovarian cancer through induction of DNA damage and inhibition of DNA repair	15
Tumor-immune ecosystem dynamics define an individual Radiation Immune Score to predict pan-cancer radiocurability	15
The p53-inducible CLDN7 regulates colorectal tumorigenesis and has prognostic significance	15
Hypoxia theranostics of a human prostate cancer xenograft and the resulting effects on the tumor microenvironment	15
Breast cancer cell debris diminishes therapeutic efficacy through heme oxygenase-1-mediated inactivation of M1-like tumor-associated macrophages	14
Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1)	14
Diet-microbiome interactions in cancer treatment: Opportunities and challenges for precision nutrition in cancer	14
A systematic review of microbiome-derived biomarkers for early colorectal cancer detection	14
Real-time sensing of MAPK signaling in medulloblastoma cells reveals cellular evasion mechanism counteracting dasatinib blockade of ERK activation during invasion	14
A cohesive look at leukemogenesis: The cohesin complex and other driving mutations in AML	13
Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway	13
TROY signals through JAK1-STAT3 to promote glioblastoma cell migration and resistance	13
Pediatric low-grade glioma: Targeted therapeutics and clinical trials in the molecular era	13
Neddylation inactivation represses androgen receptor transcription and inhibits growth, survival and invasion of prostate cancer cells	13
Microbiota-driven mechanisms at different stages of cancer development	13
SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT pathway	13

Targeting hypoxia regulated sodium driven bicarbonate transporters reduces triple negative breast cancer metastasis	13
Tumor treating fields (TTFields) impairs aberrant glycolysis in glioblastoma as evaluated by [18F]DASA-23, a non-invasive probe of pyruvate kinase M2 (PKM2) expression	13
Panobinostat enhances olaparib efficacy by modifying expression of homologous recombination repair and immune transcripts in ovarian cancer	13
BRAF inhibition in melanoma is associated with the dysregulation of histone methylation and histone methyltransferases	13
Cancer: A turbulence problem	12
Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition	12
c-Myb interferes with inflammatory IL1α-NF-κB pathway in breast cancer cells	12
Cross-talk among MEN1, p53 and Notch regulates the proliferation of pancreatic neuroendocrine tumor cells by modulating INSM1 expression and subcellular localization	12
SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma	12
High tumor mutation burden predicts favorable outcome among patients with aggressive histological subtypes of lung adenocarcinoma: A population-based single-institution study	12
Prognostic alternative mRNA splicing signatures and associated splicing factors in acute myeloid leukemia	12
The interleukin-1 axis and the tumor immune microenvironment in pancreatic ductal adenocarcinoma	12
Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype	12
Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis	12
Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas	12
The anti-B7-H4 checkpoint synergizes trastuzumab treatment to promote phagocytosis and eradicate breast cancer	12
Circ_0089823 reinforces malignant behaviors of non-small cell lung cancer by acting as a sponge for microRNAs targeting SOX4,	11
Proprotein convertase subtilisin/kexin Type 9 is required for Ahnak-mediated metastasis of melanoma into lung epithelial cells	11
Deep tissue volumetric optoacoustic tracking of individual circulating tumor cells in an intracardially perfused mouse model	11
Fusobacterium nucleatum stimulates cell proliferation and promotes PD-L1 expression via IFIT1-related signal in colorectal cancer	11
STAMBP promotes lung adenocarcinoma metastasis by regulating the EGFR/MAPK signaling pathway	11
Combining selinexor with alisertib to target the p53 pathway in neuroblastoma	11
Targeting methyltransferase PRMT5 retards the carcinogenesis and metastasis of HNSCC via epigenetically inhibiting Twist1 transcription	11
Suppression of ER-stress induction of GRP78 as an anti-neoplastic mechanism of the cardiac glycoside Lanatoside C in pancreatic cancer	11
Understanding the roles of N6-methyladenosine writers, readers and erasers in breast cancer	11
Reduction in mitochondrial oxidative stress mediates hypoxia-induced resistance to cisplatin in human transitional cell carcinoma cells	10
Past, present and future of Focused Ultrasound as an adjunct or complement to DIPG/DMG therapy: A consensus of the 2021 FUSF DIPG meeting	10
Carcinogenesis induced by space radiation: A systematic review	10
Proteome biology of primary colorectal carcinoma and corresponding liver metastases	10
Epigenome-wide DNA methylation profiling of portal vein tumor thrombosis (PVTT) tissues in hepatocellular carcinoma patients	10
Eucannabinolide, a novel sesquiterpene lactone, suppresses the growth, metastasis and BCSCS-like traits of TNBC via inactivation of STAT3	10
Targeted and explorative profiling of kallikrein proteases and global proteome biology of pancreatic ductal adenocarcinoma, chronic pancreatitis, and normal pancreas highlights disease-specific proteo	10
A glypican-1-targeted antibody-drug conjugate exhibits potent tumor growth inhibition in glypican-1-positive pancreatic cancer and esophageal squamous cell carcinoma	10
Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma	10
Non-melanoma skin cancers: physio-pathology and role of lipid delivery systems in new chemotherapeutic treatments	10
Injured tissues favor cancer cell implantation via fibrin deposits on scar zones	9
Genomic characterization of Chinese ovarian clear cell carcinoma identifies driver genes by whole exome sequencing	9
Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations	9
Identification of disease-promoting stromal components by comparative proteomic and transcriptomic profiling of canine mammary tumors using laser-capture microdissected FFPE tissue	9
Upregulation of HIF1-α via an NF-κB/COX2 pathway confers proliferative dominance of HER2-negative ductal carcinoma in situ cells in response to inflammatory stimuli	9
Noninvasive optoacoustic microangiography reveals dose and size dependency of radiation-induced deep tumor vasculature remodeling	9
Molecular homology between canine spontaneous oral squamous cell carcinomas and human head-and-neck squamous cell carcinomas reveals disease drivers and therapeutic vulnerabilities	9
TGFBR2 mediated phosphorylation of BUB1 at Ser-318 is required for transforming growth factor-β signaling	9
miR-524-5p reduces the progression of the BRAF inhibitor-resistant melanoma	9
Tumor cell endogenous HIF-1α activity induces aberrant angiogenesis and interacts with TRAF6 pathway required for colorectal cancer development	9
Inhibition of DNA-PK may improve response to neoadjuvant chemoradiotherapy in rectal cancer	9
The breast tissue microbiome, stroma, immune cells and breast cancer	9
Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation	9
High dose acetaminophen inhibits STAT3 and has free radical independent anti-cancer stem cell activity	9
STAT3 contributes to cisplatin resistance, modulating EMT markers, and the mTOR signaling in lung adenocarcinoma	9
Synergizing radiotherapy and immunotherapy: Current challenges and strategies for optimization	9
Ex vivo assessment of targeted therapies in a rare metastatic epithelial–myoepithelial carcinoma	9
The paradox of radiation and T cells in tumors	9
In vivo two-photon characterization of tumor-associated macrophages and microglia (TAM/M) and CX3CR1 during different steps of brain metastasis formation from lung cancer	9
Exome sequencing identifies frequent genomic loss of TET1 in IDH-wild-type glioblastoma	8
Spectroscopic investigation of radiation-induced reoxygenation in radiation-resistant tumors	8
SHC014748M, a novel selective inhi-bitor of PI3Kδ, demonstrates promising preclinical antitumor activity in B cell lymphomas and chronic lymphocytic leukemia	8
WHSC1 monomethylates histone H1 and induces stem-cell like features in squamous cell carcinoma of the head and neck	8
The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53	8
Naproxen inhibits spontaneous lung adenocarcinoma formation in KrasG12V mice	8
Mathematical modeling of PDGF-driven glioma reveals the dynamics of immune cells infiltrating into tumors	8
Does the proteasome inhibitor bortezomib sensitize to DNA-damaging therapy in gastroenteropancreatic neuroendocrine neoplasms? – A preclinical assessment in vitro and in vivo	8
CBP-mediated Wnt3a/β-catenin signaling promotes cervical oncogenesis initiated by Piwil2	8
Niche-derived soluble DLK1 promotes glioma growth	8
Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines	8
Spatial distribution of immune checkpoint proteins in histological subtypes of lung adenocarcinoma	8
Tumor necrosis factor receptor signaling modulates carcinogenesis in a mouse model of breast cancer	8
PAD4-dependent citrullination of nuclear translocation of GSK3β promotes colorectal cancer progression via the degradation of nuclear CDKN1A	8
Role of heparanase 2 (Hpa2) in gastric cancer	8
Suppression of CCDC6 sensitizes tumor to oncolytic virus M1	8
Locoregional CAR T cells for children with CNS tumors: Clinical procedure and catheter safety	8
Inhibition of fibronectin accumulation suppresses tumor growth	8
IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells	8
Myelodysplastic syndromes: Biological and therapeutic consequences of the evolving molecular aberrations landscape	7
Myeloperoxidase exerts anti-tumor activity in glioma after radiotherapy	7
Optical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer	7
Therapeutic significance of ARID1A mutation in bladder cancer	7
miR-138-5p induces aggressive traits by targeting Trp53 expression in murine melanoma cells, and correlates with poor prognosis of melanoma patients	7
Ovulation sources coagulation protease cascade and hepatocyte growth factor to support physiological growth and malignant transformation	7
Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer	7

Overcoming ABCB1-mediated multidrug resistance by transcription factor BHLHE40	7
Hepatocellular carcinoma-derived FOXO1 inhibits tumor progression by suppressing IL-6 secretion from macrophages	7
Colorectal cancer, Vitamin D and microbiota: A double-blind Phase II randomized trial (ColoViD) in colorectal cancer patients	7
Genomic landscape of metastatic lung adenocarcinomas from large-scale clinical sequencing	7
Therapeutic avenues for targeting treatment challenges of diffuse midline gliomas	7
Global molecular alterations involving recurrence or progression of pediatric brain tumors	6
Regulation of growth, invasion and metabolism of breast ductal carcinoma through CCL2/CCR2 signaling interactions with MET receptor tyrosine kinases	6
mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer	6
Lung cancer lesion detection in histopathology images using graph‐based sparse PCA network	6
Differentiated embryonic chondrocyte expressed gene-1 (DEC1) enhances the development of colorectal cancer with an involvement of the STAT3 signaling	6
p85β alters response to EGFR inhibitor in ovarian cancer through p38 MAPK-mediated regulation of DNA repair	6
PEGPH20, a PEGylated human hyaluronidase, induces radiosensitization by reoxygenation in pancreatic cancer xenografts. A molecular imaging study	6
Radiation-induced lymphopenia does not impact treatment efficacy in a mouse tumor model	6
From adenoma to CRC stages: the oral-gut microbiome axis as a source of potential microbial and metabolic biomarkers of malignancy	6
Therapeutic effiacy of T cells expressing chimeric antigen receptor derived from a mesothelin-specific scFv in orthotopic human pancreatic cancer animal models	6
Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma	6
Cell competition, cooperation, and cancer	6
Copy number alteration of the interferon gene cluster in cancer: Individual patient data meta-analysis prospects to personalized immunotherapy	6
Evaluating the efficacy of enzalutamide and the development of resistance in a preclinical mouse model of type-I endometrial carcinoma	6
Detection of circulating tumor DNA without a tumor-informed search using next-generation sequencing is a prognostic biomarker in pancreatic ductal adenocarcinoma	6
Cyst fluid metabolites distinguish malignant from benign pancreatic cysts	6
The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells	6
Unsupervised machine learning using K-means identifies radiomic subgroups of pediatric low-grade gliomas that correlate with key molecular markers	6
Amelioration of muscle wasting by gintonin in cancer cachexia	6
Hedgehog/GLI1 Transcriptionally Regulates FANCD2 in Ovarian Tumor Cells: Its Inhibition Induces HR-Deficiency and Synergistic Lethality with PARP Inhibition.	6
MET inhibition downregulates DR4 expression in MET-amplified lung cancer cells with acquired resistance to EGFR inhibitors through suppressing AP-1-mediated transcription	6
Transgenic expression of Sag/Rbx2 E3 causes early stage tumor promotion, late stage cytogenesis and acinar loss in the Kras–PDAC model	5
Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor	5
U-RT1 – A new model for Richter transformation	5
Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature	5
Molecular subtypes based on CNVs related gene signatures identify candidate prognostic biomarkers in lung adenocarcinoma	5
Strength and duration of GIPC-dependent signaling networks as determinants in cancer	5
MDM2 amplification and fusion gene ss18-ssx in a poorly differentiated synovial sarcoma: A rare but puzzling conjunction	5
Molecular mechanisms of Guadecitabine induced FGFR4 down regulation in alveolar rhabdomyosarcomas	5
Role of AMPK and Akt in triple negative breast cancer lung colonization	5
Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction	5
PRMT1 methylates METTL14 to modulate its oncogenic function	5
DNA polymerase β deficiency promotes the occurrence of esophageal precancerous lesions in mice	5
Nuclear morphology predicts cell survival to cisplatin chemotherapy	5
Antibiotic treatment targeting gram negative bacteria prevents neratinib-induced diarrhea in rats	5
Whole-chromosome arm acquired uniparental disomy in cancer development is a consequence of isochromosome formation	5
Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells	5
Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11	5
Patient-specific molecular response dynamics can predict the possibility of relapse during the second treatment-free remission attempt in chronic myelogenous leukemia	5
HDAC6 promotes aggressive development of liver cancer by improving egfr mRNA stability	5
Mcl-1 levels critically impact the sensitivities of human colorectal cancer cells to APG-1252-M1, a novel Bcl-2/Bcl-XL dual inhibitor that induces Bax-dependent apoptosis	5