OOIR: Observatory of International Research

Papers

(The TQCC of Neoplasia is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Filamin a binds deleted in liver cancer 1 (DLC1) to promote its tumor suppressor activity and inhibit the SRF coactivator MRTF-A	79
Visualizing mast cell migration to tumor sites using sodium iodide symporter of nuclear medicine reporter gene	76
Sialylated IgG-activated integrin β4-Src-Erk axis stabilizes c-Myc in a p300 lysine acetyltransferase-dependent manner to promote colorectal cancer liver metastasis	74
Corrigendum to “Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells” [Neoplasia 17 (2014) 85]	68
Corrigendum to “Tumorigenicity of IL-1α- and IL-1β-Deficient Fibrosarcoma Cells” [Neoplasia, Volume 10, Issue 6, June 2008, Pages 549–562]	67
Identification of molecularly targeted therapy-induced immunopeptidome in diffuse midline glioma (DMG)	56
High metastatic tumor-derived CXCL16 mediates liver colonization metastasis by inducing Kupffer cell polarization via the PI3K/AKT/FOXO3a pathway	55
DHX34 deficiency triggers tumor-intrinsic immunity via a dsRNA-mediated type I interferon pathway activation in HCC	55
Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma	54
ARID1A loss sensitizes colorectal cancer cells to floxuridine	49
Epitranscriptomic mechanisms of androgen signalling and prostate cancer	49
Single cell analysis unveils the commonality and heterogeneity between nasopharyngeal and oropharyngeal carcinoma	46
The benefit of deep genomic testing for asymptomatic high-risk individuals undergoing surveillance for pancreatic adenocarcinoma: European registry for hereditary pancreatic diseases (EUROPAC-PLUS)	45
5-Aza-2′-deoxycytidin (Decitabine) increases cancer-testis antigen expression in head and neck squamous cell carcinoma and modifies immune checkpoint expression, especially in CD39-positive CD8 and CD	44
BPGM as an intrinsic brake to constrain metastasis through phospho-epigenetic-mediated carnitine biosynthesis suppression	43
L-methionine promotes CD8+ T cells killing hepatocellular carcinoma by inhibiting NR1I2/PCSK9 signaling	43
Mutational signatures and their association with survival and gene expression in urological carcinomas	43
RUNX2 enhances bladder cancer progression by promoting glutamine metabolism	41
Myxoid glioneuronal tumor: Histopathologic, neuroradiologic, and molecular features in a single center series	40
New horizons in B-cell lymphoma immunotherapy: From immune checkpoints to precision medicine	37
Combination of sunitinib and 177Lu-labeled antibody cG250 targeted radioimmunotherapy: A promising new therapeutic strategy for patients with advanced renal cell cancer	37
CCAAT‐enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemia	35
Tumor-Infiltrating Immune Cells in Colorectal Cancer	35
Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice	34
From adenoma to CRC stages: the oral-gut microbiome axis as a source of potential microbial and metabolic biomarkers of malignancy	33

Retraction notice to “Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors” [Neoplasia 18 (2016) 347- 355/201]	33
Innate immunity: Looking beyond T-cells in radiation and immunotherapy combinations	32
Rezatapopt: A promising small-molecule “refolder” specific for TP53Y220C mutant tumors	32
Identification of recurrent BRAF non-V600 mutations in intraductal carcinoma of the prostate in Chinese populations	32
A spatiotemporal atlas of orchiectomy-induced androgen deprivation-mediated modulation of cellular composition and gene expression in the mouse prostate	31
Epigenetic DNA modifications and vitamin C in prostate cancer and benign prostatic hyperplasia: Exploring similarities, disparities, and pathogenic implications	30
PDGFRα governs multiple cellular signals and plays a protective role in tumor progression	30
Advanced progress of spatial metabolomics in head and neck cancer research	30
Lactate promoted cisplatin resistance in NSCLC by modulating the m6A modification-mediated FOXO3/MAGI1-IT1/miR-664b-3p/IL-6R axis	30
Leptomeningeal dissemination in pediatric brain tumors	29
Metabolic and imaging phenotypes associated with RB1 and TP53 loss in prostate cancer	29
The role of glycolysis in tumorigenesis: From biological aspects to therapeutic opportunities	26
Reciprocal regulation of lncRNA MEF and c-Myc drives colorectal cancer tumorigenesis	26
Regulatory mechanisms of the Hippo/YAP axis by G-protein coupled estrogen receptor in gastric signet-ring cell carcinoma	26
An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors	26
Colorectal cancer, Vitamin D and microbiota: A double-blind Phase II randomized trial (ColoViD) in colorectal cancer patients	26
Longitudinal genomic alternations and clonal dynamics analysis of primary malignant melanoma of the esophagus	26
Incidence, mortality, and global burden of retinoblastoma in 204 countries worldwide from 1990 to 2021: Data and systematic analysis from the Global Burden of Disease Study 2021	25
Evidence based on Mendelian randomization: Causal relationship between mitochondrial biological function and lung cancer and its subtypes	24
PDGF-BB overexpression in p53 null oligodendrocyte progenitors increases H3K27me3 and induces transcriptional changes which favor proliferation	24
β-Catenin mediated TAM phenotype promotes pancreatic cancer metastasis via the OSM/STAT3/LOXL2 axis	24
A novel regimen for pancreatic ductal adenocarcinoma targeting MEK, BCL-xL, and EGFR	23
PRAS40 activates the IRE1α-XBP-1-mediated unfolded protein response to exacerbate colorectal cancer by enhancing ST6Gal1-dependent α-2, 6 sialylation of GRP78	23
Aurkin-A, a TPX2-Aurora A small molecule inhibitor disrupts Alisertib-induced polyploidy in aggressive diffuse large B cell lymphoma	23
HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma	22
Tumor-associated macrophages promote bladder cancer metastasis through the CCL20-CCR6 axis	22
Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats	22
A systematic review of microbiome-derived biomarkers for early colorectal cancer detection	22
Overexpression of the miR-17-92 cluster in colorectal adenoma organoids causes a carcinoma-like gene expression signature	22
Single-cell proteomic analysis reveals Multiple Myeloma heterogeneity and the dynamics of the tumor immune microenvironment in precursor and advanced states	22
Enhancing the antitumor efficacy using a combination of FGFR4 Inhibitor (H3B-6527) and oxaliplatin in gastric cancer	21
High dose acetaminophen re-polarizes CD11b+ cells in the tumor microenvironment towards an activated macrophage phenotype	21
Indigenous peoples and inclusion in clinical and genomic research: Understanding the history and navigating contemporary engagement	21
Corrigendum to “SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT Pathway” [Neoplasia (2021) 23, 1037–1047]	21
Pediatric neuro-oncology: Highlights of the last quarter-century	20
SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer	20
Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1)	20
Inhibiting HnRNP L-mediated alternative splicing of EIF4G1 counteracts immune checkpoint blockade resistance in Castration-resistant prostate Cancer	20
The DNA mismatch repair protein, MSH6 is a novel regulator of PD-L1 expression	20
Composition of gastrointestinal microbiota in association with treatment response in individuals with metastatic castrate resistant prostate cancer progressing on enzalutamide and initiating treatment	19
Acral melanoma: new insights into the immune and genomic landscape	19
Aurora kinase B is required for growth and expansion of medulloblastoma cells in the tissue context	19
IGDQ motogenic peptide gradient induces directional cell migration through integrin (αv)β3 activation in MDA-MB-231 metastatic breast cancer cells	18
Comparative effects of combustible cigarette versus electronic cigarette exposures on KRAS mutant lung cancer promotion	18
PBI-05204, a supercritical CO2 extract of Nerium oleander, suppresses glioblastoma stem cells by inhibiting GRP78 and inducing programmed necroptotic cell death	18
High-throughput sequencing and in-silico analysis confirm pathogenicity of novel MSH3 variants in African American colorectal cancer	18
BRAF p.V600E mutation as a molecular boundary between genuine oligo-repeated and poly-metastatic disease in colorectal cancer	17
Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor	17
Early separation and parallel clonal selection of dedifferentiated and well-differentiated components in dedifferentiated liposarcoma	17
PAX8 modulates the tumor microenvironment of high grade serous ovarian cancer through changes in the secretome	17

Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma	17
Experimental study of tumor-associated macrophage-derived SPP1 inhibit CD8+ T cells to promote Colorectal cancer progression	17
Carcinogenesis induced by space radiation: A systematic review	17
Microbial crosstalk along the oral–gut axis: organ-specific oncogenic adaptations of Porphyromonas gingivalis and Fusobacterium nucleatum	16
MYH knockdown in pancreatic cancer cells creates an exploitable DNA repair vulnerability	16
Structure and function of the lysine methyltransferase SETD2 in cancer: From histones to cytoskeleton	16
Dopamine receptor D2 regulates glioblastoma survival and death through MET and death receptor 4/5	16
Identification of TUBB3 as an immunotherapy target in lung cancer by genome wide in vivo CRISPR screening	16
Spatial profiling of METex14-altered NSCLC under tepotinib treatment: Shifting the immunosuppressive landscape	16
Corrigendum to “Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma” [Neoplasia, Volume 21, Issue 3 (2019) 322–330]	15
Unveiling the impact of SUMOylation at K298 site of heat shock factor 1 on glioblastoma malignant progression	15
Clonal architecture of FLT3-ITD and acquired 13q uniparental disomy define prognostic heterogeneity and therapeutic vulnerabilities in acute myeloid leukemia	15
PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapy	15
Current state of pediatric neuro-oncology imaging, challenges and future directions	15
Genomics driven precision oncology in advanced biliary tract cancer improves survival	15
Dynasore as a dual modulator of lipid rafts and cell death in pancreatic cancer	15
Targeting myeloma metabolism: How abnormal metabolism contributes to multiple myeloma progression and resistance to proteasome inhibitors	14
Impact of tissue penetration and albumin binding on design of T cell targeted bispecific agents	14
Dual CDK4/6–PI3K/mTOR inhibition reinforces cytostatic programs and tumor control in preclinical models of primary and metastatic osteosarcoma	14
Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances.	14
Bacterial translocation and barrier dysfunction enhance colonic tumorigenesis	14
Systemic inflammation in response to radiation drives the genesis of an immunosuppressed tumor microenvironment	14
Metformin use and survival in people with ovarian cancer: A population-based cohort study from British Columbia, Canada	14
Corrigendum to “Tumor Therapy Mediated by Lentiviral Expression of shBcl-2 and S-TRAIL” [Neoplasia. Vol. 9, No. 5, May 2007, pp. 435–442]	13
Tamoxifen promotes metastasis of breast cancer via reshaping lipid-driven fibrotic microenvironments in the lung	13
LncRNA HOTAIRM1 promotes radioresistance in nasopharyngeal carcinoma by modulating FTO acetylation-dependent alternative splicing of CD44	13
FAPα and αSMA mark different subsets of fibroblasts in normal kidney and conventional renal cell carcinoma	13
Spatial organization of heterogeneous immunotherapy target antigen expression in high-grade glioma	13
Motion based ex vivo (MOTEX) culture of breast tumor slices sustains microenvironment composition	13
Oral bioavailable ITRI-148 degrades androgen receptor variants and overcomes antiandrogen resistance in advanced prostate cancer	13
Genetic loss of CHD1 regulates distinct histone post-translational modifications in the development of castration-resistant prostate cancer	13
Steatohepatitis alters lymphocytes cytotoxicity and localization, accelerating colorectal liver metastases	13
Proteomic profiling of canine fibrosarcoma and adjacent peritumoral tissue	12
A novel microprotein MUCP1 promotes colorectal cancer metabolic reprogramming by regulating mitochondrial succinate transport	12
Activation of PERK/eIF2α/ATF4 signaling inhibits ERα expression in breast cancer	12
Synergizing radiotherapy and immunotherapy: Current challenges and strategies for optimization	12
CYP1B1 promotes angiogenesis and sunitinib resistance in clear cell renal cell carcinoma via USP5-mediated HIF2α deubiquitination	12
Regulation of growth, invasion and metabolism of breast ductal carcinoma through CCL2/CCR2 signaling interactions with MET receptor tyrosine kinases	12
Regulation of prostate-specific membrane antigen (PSMA) expression in prostate cancer cells after treatment with dutasteride and lovastatin	12
Comprehensive profiling of EGFR mutation subtypes reveals genomic-clinical associations in non-small-cell lung cancer patients on first-generation EGFR inhibitors	12
DARPP-32 and t-DARPP in the development of resistance to anti-HER2 agents. Pre-clinical evidence from the STEP study	12
Corrigendum to “DNA-methylation eraser TET2 activates WTIP expression to suppress an AKT-dependent chemoresistance of gastric cancer” [Neoplasia volume 2025 Apr 24:65:101166]	12
Phase I clinical trial of a novel procaspase-3 activator SM-1 with temozolomide in recurrent high-grade gliomas	12
The TRIM22-CDT2 axis is the key mediator of the p53-Rb signals in growth control of HPV-positive cervical carcinoma cells	11
ΔNp63 silencing, DNA methylation shifts, and epithelial-mesenchymal transition resulted from TAp63 genome editing in squamous cell carcinoma	11
Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen Signaling promotes oncogenic functions in HPV16 positive head and neck cancer	11
Multimodal profiling of oral squamous cell carcinoma identifies genomic alterations and expression programs associated with betel quid chewing	11
Saturated fat exacerbates mitochondrial dysfunction through remodelling of ATP production and inflammation in Barrett’s oesophagus compared to monounsaturated fat, particularly in contrast to oesophag	11
AEBP1 promotes papillary thyroid cancer progression by activating BMP4 signaling	11
The kinetics of blast clearance are associated with copy number alterations in childhood B-cell acute lymphoblastic leukemia	11
Furin, ADAM, and γ-secretase: Core regulatory targets in the Notch pathway and the therapeutic potential for breast cancer	11
Metformin combined with cisplatin reduces anticancer activity via ATM/CHK2-dependent upregulation of Rad51 pathway in ovarian cancer	11
Generation of orthotopic intracranial glioblastoma patient-derived xenograft models: insights into extrachromosomal DNA-driven MYC(N) and PDGFRA oncogene amplification and preliminary therapeutic eval	11
Differential prognostic association of systemic inflammatory biomarkers on survival outcomes in head and neck squamous cell carcinoma patients by human papillomavirus status	11
SMARCA4 deficiency in glioblastoma: Mitochondrial transfer from MSCs and the clinical dilemma in targeting the tumor microenvironment	11
Corrigendum to “Single-cell proteomic analysis reveals Multiple Myeloma heterogeneity and the dynamics of the tumor immune microenvironment in precursor and advanced states” [Neoplasia 66 (2025) 11011	11
Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma	11
RUNX2 prompts triple negative breast cancer drug resistance through TGF-β pathway regulating breast cancer stem cells	11
Contribution of the immune bone marrow microenvironment to tumor growth and bone deconstruction: implications for improving immunotherapeutic strategies in bone metastasis	11