Organic & Biomolecular Chemistry

Article	Citations
Thioxanthone: a powerful photocatalyst for organic reactions	110
Advances in deep eutectic solvents and water: applications in metal- and biocatalyzed processes, in the synthesis of APIs, and other biologically active compounds	89
The chemistry and biology of fungal meroterpenoids (2009–2019)	79
Recent advances in Rh(iii)/Ir(iii)-catalyzed C–H functionalization/annulation via carbene migratory insertion	78
Recent advances in ring-opening of donor acceptor cyclopropanes using C-nucleophiles	77
Metal-catalyzed C–S bond formation using sulfur surrogates	67
Recent advances in using 4DPAIPN in photocatalytic transformations	66
Tris(pentafluorophenyl)borane catalyzed C–C and C–heteroatom bond formation	57
Recent advances in the synthesis and reactivity of azetidines: strain-driven character of the four-membered heterocycle	56
Recent advancements in the development of molecular organic photocatalysts	56
Recent advances in transition metal-free annulation toward heterocycle diversity based on the C–N bond cleavage of enaminone platform	54
Multicomponent reactions as a potent tool for the synthesis of benzodiazepines	52
Recent advances in aminative difunctionalization of alkenes	51
Silicon phthalocyanines: synthesis and resurgent applications	49
Modern approaches towards the synthesis of geminal difluoroalkyl groups	48
Recent advances in the synthesis of α-amino ketones	48
Optical sensing of anions by macrocyclic and interlocked hosts	44
Metallaphotoredox catalysis with organic dyes	44
Visible-light-induced silylation: an update	43
Recent advances in the synthesis and applications of β-keto sulfones: new prospects for the synthesis of β-keto thiosulfones	43
Electrohalogenation of organic compounds	42
Photoaffinity labelling strategies for mapping the small molecule–protein interactome	42
Metal-free multicomponent reactions: a benign access to monocyclic six-membered N-heterocycles	41
Light-induced borylation: developments and mechanistic insights	41
Recent advances in nickel-catalyzed C–C and C–N bond formation via HA and ADC reactions	40

Construction of bridged polycycles through dearomatization strategies	40
Recent progress on electrochemical synthesis involving carboxylic acids	40
Recent developments in asymmetric Heck type cyclization reactions for constructions of complex molecules	39
Recent progress in the synthesis of pyrrolo[2,1-a]isoquinolines	38
Nickel catalysts in Sonogashira coupling reactions	38
Recent advances in single-benzene-based fluorophores: physicochemical properties and applications	37
Recent advances in the Rh-catalyzed cascade arene C–H bond activation/annulation toward diverse heterocyclic compounds	37
Recent advances in the synthesis of indolizine and its derivatives by radical cyclization/cross-coupling	37
Electrochemical synthesis of sulfonated benzothiophenes using 2-alkynylthioanisoles and sodium sulfinates	37
Recent developments in enantio- and diastereoselective hydrogenation of N-heteroaromatic compounds	36
Strategies for organelle targeting of fluorescent probes	35
Removal and modification of directing groups used in metal-catalyzed C–H functionalization: the magical step of conversion into ‘conventional’ functional groups	35
Asymmetric synthesis of organophosphorus compounds using H–P reagents derived from chiral alcohols	35
Ruthenium(ii) complexes with N-heterocyclic carbene–phosphine ligands for the N-alkylation of amines with alcohols	34
Overview of coumarin-fused-coumarins: synthesis, photophysical properties and their applications	34
Approaches for peptide and protein cyclisation	34
Reactions promoted by hypervalent iodine reagents and boron Lewis acids	33
Forgotten and forbidden chemical reactions revitalised through continuous flow technology	33
Electrochemical regioselective C–H selenylation of 2H-indazole derivatives	33
Copper-catalyzed Goldberg-type C–N coupling in deep eutectic solvents (DESs) and water under aerobic conditions	32
α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update	32
Cycloaddition of cyclopropanes for the elaboration of medium-sized carbocycles	32
An update on the progress of cycloaddition reactions of 3-methyleneindolinones in the past decade: versatile approaches to spirooxindoles	32
Iminosugars as glycosyltransferase inhibitors	32
Metal–ligand cooperative approaches in homogeneous catalysis using transition metal complex catalysts of redox noninnocent ligands	32
Expeditious entry into carbocyclic and heterocyclic spirooxindoles	32
Advances in palladium-catalysed imidoylative cyclization of functionalized isocyanides for the construction of N-heterocycles	31
Electrosynthetic C–F bond cleavage	30
Synthesis of 2H-chromenes: recent advances and perspectives	30
Beyond osmium: progress in 1,2-amino oxygenation of alkenes, 1,3-dienes, alkynes, and allenes	29
Eosin: a versatile organic dye whose synthetic uses keep expanding	29
Visible-light-mediated cascade cyanoalkylsulfonylation/cyclization of alkynoates leading to coumarins via SO2 insertion	29
Rh(iii)-catalyzed C–H annulation of sulfoxonium ylides with iodonium ylides towards isocoumarins	29
Halogen bond-induced electrophilic aromatic halogenations	29
Ionic liquids: “normal” solvents or nanostructured fluids?	29
Red-shifted tetra-ortho-halo-azobenzenes for photo-regulated transmembrane anion transport	29
Hancockiamides: phenylpropanoid piperazines from Aspergillus hancockii are biosynthesised by a versatile dual single-module NRPS pathway	28
Indicator displacement assays: from concept to recent developments	28
Recent progress of direct thiocyanation reactions	28
Reframing primary alkyl amines as aliphatic building blocks	28
Molecular cages for biological applications	28
Total synthesis of apratoxin A and B using Matteson's homologation approach	28
Peroxide-mediated synthesis of benzimidazo[2,1-a]isoquinoline-6(5H)-ones via cascade methylation/ethylation and intramolecular cyclization	27
Recent advances in the synthesis of pyrido[1,2-a]indoles	27
Applications of catalysis in hydroboration of imines, nitriles, and carbodiimides	27
Recent advances in the applications of pyrazolone derivatives in enantioselective synthesis	27
Green solvents for the formation of amide linkages	27
Recent developments in the synthesis of nitrogen-containing heterocycles from β-aminovinyl esters/ketones as CC–N donors	26
Phosphorus containing porous organic polymers: synthetic techniques and applications in organic synthesis and catalysis	26
Facile synthesis of carbamoylated benzimidazo[2,1-a]isoquinolin-6(5H)-ones via radical cascade cyclization under metal-free conditions	26

CpxM(iii)-catalyzed enantioselective C–H functionalization through migratory insertion of metal–carbenes/nitrenes	26
Asparaginyl endopeptidases: enzymology, applications and limitations	25
A comprehensive insight into aldehyde deformylation: mechanistic implications from biology and chemistry	25
Controlling selectivity in N-heterocycle directed borylation of indoles	25
Exploration of Kobayashi's aryne precursor: a potent reactive platform for the synthesis of polycyclic aromatic hydrocarbons	25
DABSO as a SO2 gas surrogate in the synthesis of organic structures	25
An expeditious and highly efficient synthesis of substituted pyrroles using a low melting deep eutectic mixture	24
Recent progress in the nitration of arenes and alkenes	24
Visible-light-promoted selective O-alkylation of 2-pyridones with α-aryldiazoacetates	24
Copper-catalyzed P–H insertion reactions of sulfoxonium ylides	24
Stereodivergent Pd/Cu catalysis: asymmetric alkylation of racemic symmetrical 1,3-diphenyl allyl acetates	24
Nickel catalyzed sustainable synthesis of benzazoles and purines via acceptorless dehydrogenative coupling and borrowing hydrogen approach	24
Synthesis and reactivity of alkynyl boron compounds	24
A reference scale of cucurbit[7]uril binding affinities	24
Updates on hypervalent-iodine reagents: metal-free functionalisation of alkenes, alkynes and heterocycles	24
Copper-catalyzed radical cascade cyclization for synthesis of CF3-containing tetracyclic benzimidazo[2,1-a]iso-quinolin-6(5H)-ones	24
Recent advances in reactions using diacyl peroxides as sources of O- and C-functional groups	24
Current developments in the synthesis of 4-chromanone-derived compounds	24
Iodine–TBHP mediated efficient synthesis of α-ketoamides from vinyl azides and amines under mild conditions	24
Catalyst-free and additive-free reactions enabling C–C bond formation: a journey towards a sustainable future	24
Synthesis and derivatization of hetera-buckybowls	24
Recent approaches to the synthesis of tetrahydrocarbazoles	23
Recent advances on triptycene derivatives in supramolecular and materials chemistry	23
Transition-metal-catalyzed ortho-selective C–H functionalization reactions of free phenols	22
Synthesis of polychloromethylated and halogenated spiro[5,5]trienones via dearomative spirocyclization of biaryl ynones	22
C(sp2)–H functionalization in non-aromatic azomethine-based heterocycles	22
Metal-catalyzed reactions of organic nitriles and boronic acids to access diverse functionality	22
Recent highlights of biosynthetic studies on marine natural products	22
Recent advances in the transition metal-free oxidative dehydrogenative aromatization of cyclohexanones	22
Recent advances in the synthesis of pyrrolo[1,2-a]indoles and their derivatives	22
Sulfur(vi) fluorides as tools in biomolecular and medicinal chemistry	21
Recent advances in palladium-catalyzed C(sp3)/C(sp2)–H bond functionalizations: access to C-branched glycosides	21
Stereoselective synthesis of fused-, spiro- and bridged heterocycles via cyclization of isoquinolinium salts: a recent update	21
Artificial enzymes bringing together computational design and directed evolution	21
Predicting the catalytic activity of azolium-based halogen bond donors: an experimentally-verified theoretical study	21
Recent advances in pyrazole synthesis employing diazo compounds and synthetic analogues	21
Azulene as an ingredient for visible-light- and stimuli-responsive photoswitches	21
Construction of an IMiD-based azide library as a kit for PROTAC research	21
Dinuclear zinc-catalyzed enantioselective formal [3 + 2] cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with low reactivity aurone derivatives	21
Carbon dioxide based methodologies for the synthesis of fine chemicals	21
A Zn(ii)-functionalized COF as a recyclable catalyst for the sustainable synthesis of cyclic carbonates and cyclic carbamates from atmospheric CO2	21
Hydroxyl-group-activated azomethine ylides in organocatalytic H-bond-assisted 1,3-dipolar cycloadditions and beyond	21
Application of DMSO as a methylthiolating reagent in organic synthesis	21
Total synthesis of the pseudoindoxyl class of natural products	21
Synthesis and stereoselective catalytic transformations of 3-hydroxyisoindolinones	20
Conjugated ynones in catalytic enantioselective reactions	20
Synthesis of functionalized indoles via cascade benzannulation strategies: a decade's overview	20
Catalytic asymmetric synthesis of 5-membered alicyclic α-quaternary β-amino acids via [3 + 2]-photocycloaddition of α-substituted acrylates	20
Visible light-promoted photocatalyst-free activation of persulfates: a promising strategy for C–H functionalization reactions	20
NaI/KI/NH4I and TBHP as powerful oxidation systems: use in the formation of various chemical bonds	20
Cu(ii)-catalyzed domino construction of spironaphthalenones by dearomatization of β-naphthols and using N,N-dimethylaminoethanol as a C1 synthon	20
Chemical probes targeting the kinase CK2: a journey outside the catalytic box	20
Visible light-induced selenylative spirocyclization of biaryl ynones toward the formation of selenated spiro[5.5]trienones	20
A BODIPY-O-glycoside based near-infrared fluorescent sensor for serum albumin	20
The role of intermolecular forces in ionic reactions: the solvent effect, ion-pairing, aggregates and structured environment	20
An overview of metal-free sustainable nitrogen-based catalytic knoevenagel condensation reaction	20
Iodine(iii) reagents for oxidative aromatic halogenation	20
Electrocatalytic hydrogenation of benzoic acids in a proton-exchange membrane reactor	19
Genome mining of cryptic tetronate natural products from a PKS-NRPS encoding gene cluster in Trichoderma harzianum t-22	19
Gold-catalyzed hydroarylation reactions: a comprehensive overview	19
Cascade cyclization for the synthesis of indolo[2,1-α]isoquinoline derivatives via visible-light-induced halogen-atom-transfer (XAT) and hydrogen-atom-transfer (HAT)	19
Recent progress towards the transition-metal-catalyzed Nazarov cyclization of alkynes via metal carbenes	19
Direct functionalization of quinoxalin-2(1H)-one with alkanes: C(sp2)–H/C(sp3)–H cross coupling in transition metal-free mode	19
Enantioselective catalytic Povarov reactions	19
The transition-metal-catalyzed stereoselective ring-expansion of vinylaziridines and vinyloxiranes	19
NIS-promoted three-component reaction of 3-oxo-3-arylpropanenitriles with arylsulfonyl hydrazides	19
Preparation of new bicyclo[2.1.1]hexane compact modules: an opening towards novel sp3-rich chemical space	19
Selected applications of Meldrum's acid – a tutorial	19
A review on the assembly of multi-substituted pyridines via Co-catalyzed [2 + 2 + 2] cycloaddition with nitriles	19
Radical bromination-induced ipso cyclization–ortho cyclization sequence of N-hydroxylethyl-N-arylpropiolamides	18
Recent advances in transition-metal-catalyzed directed C–H alkenylation with maleimides	18
Ring closing metathesis for the construction of carbazole and indole-fused natural products	18
Crown ether–pillararene hybrid macrocyclic systems	18
Recent reports on the synthesis of γ-butenolide, γ-alkylidenebutenolide frameworks, and related natural products	18
Deuteration of terminal alkynes realizes simultaneous live cell Raman imaging of similar alkyne-tagged biomolecules	18
Chiral cyclometalated iridium complexes for asymmetric reduction reactions	18
Recent progress in organophotoredox reaction	18
A photocatalyst-free visible-light-mediated solvent-switchable route to stilbenes/vinyl sulfones from β-nitrostyrenes and arylazo sulfones	18
Synthesis of macrocyclic and medium-sized ring thiolactones via the ring expansion of lactams	18
Electro-organic synthesis: an environmentally benign alternative for heterocycle synthesis	18

C-5 selective chlorination of 8-aminoquinoline amides using dichloromethane	18
Phosphorylation of arenes, heteroarenes, alkenes, carbonyls and imines by dehydrogenative cross-coupling of P(O)–H and P(R)–H	17
Modern methods for the synthesis of perfluoroalkylated aromatics	17
Recent advances in the synthesis of 2,3-fused quinazolinones	17
Live-cell imaging of the nucleolus and mapping mitochondrial viscosity with a dual function fluorescent probe	17
N-Alkenylation of hydroxamic acid derivatives with ethynyl benziodoxolone to synthesize cis-enamides through vinyl benziodoxolones	17
Recent advances in the application of Langlois’ reagent in olefin difunctionalization	17
Unprecedented access to functionalized pyrrolo[2,1-a]isoquinolines from the domino reaction of isoquinolinium ylides and electrophilic benzannulated heterocycles	17
Synthesis and immunological evaluation of the unnatural β-linked mucin-1 Thomsen–Friedenreich conjugate	17
Visible-light-induced cascade reaction: a sustainable approach towards molecular complexity	17
Time-economical synthesis of selenofunctionalized heterocycles via I2O5-mediated selenylative heterocyclization	17
Harnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions	17
Arylcyclopropane yet in its infancy: the challenges and recent advances in its functionalization	17
Deoxygenation reactions in organic synthesis catalyzed by dioxomolybdenum(vi) complexes	17
Recent advances in C–F bond activation of trifluoromethylated carbonyl compounds and derivatives	17
Glycosyl disulfides: importance, synthesis and application to chemical and biological systems	16
Metal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions	16
Nitroarenes and nitroalkenes as potential amino sources for the synthesis of N-heterocycles	16
Silicon compounds as stoichiometric coupling reagents for direct amidation	16
Biotin-decorated NIR-absorbing nanosheets for targeted photodynamic cancer therapy	16
Generation and trapping of electron-deficient 1,2-cyclohexadienes. Unexpected hetero-Diels–Alder reactivity	16
Recent advances in the direct O-arylation of carbohydrates	16
Recent advances in the carbon–phosphorus (C–P) bond formation from unsaturated compounds by s- and p-block metals	16
N-Triflylphosphoramides: highly acidic catalysts for asymmetric transformations	16
Xanthene-based functional dyes: towards new molecules operating in the near-infrared region	16
Visible-light-promoted trifluoromethylselenolation of ortho-hydroxyarylenaminones	16
Supramolecular brush polymers prepared from 1,3,4-oxadiazole and cyanobutoxy functionalised pillar[5]arene for detecting Cu2+	16
Regioselective C–H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions	16
Sulfur-controlled and rhodium-catalyzed formal (3 + 3) transannulation of thioacyl carbenes with alk-2-enals and mechanistic insights	16
Chemoselective synthesis of fully substituted pyrroles via a one-pot four-component isocyanide-based reaction	16
Continuous-flow electrosynthesis of selenium-substituted iminoisobenzofuran via oxidative cyclization of olefinic amides and diselenides	16
Distiboranes based on ortho-phenylene backbones as bidentate Lewis acids for fluoride anion chelation	16
B(C6F5)3-catalyzed O–H insertion reactions of diazoalkanes with phosphinic acids	16
Synthesis of indolo[2,1-α]isoquinoline derivatives via metal-free radical cascade cyclization	16
Recent advances in rhodium-catalyzed C(sp2)–H (hetero)arylation	16
Chemoselective electrochemical reduction of nitroarenes with gaseous ammonia	16
Metal-free polychloromethyl radical-initiated cyclization of unactivated N-allylindoles towards pyrrolo[1,2-a]indoles	16
Generalizable synthesis of bioresponsive near-infrared fluorescent probes: sulfonated heptamethine cyanine prototype for imaging cell hypoxia	16
Recent advances in the copper-catalyzed aerobic Csp3–H oxidation strategy	16
Merging kinetic resolution with C–H activation: an efficient approach for enantioselective synthesis	15
(4 + 2) cyclization of aza-o-quinone methides with azlactones: construction of biologically important dihydroquinolinone frameworks	15
Biocatalytic approaches for enantio and diastereoselective synthesis of chiral β-nitroalcohols	15
Catalytic and highly regenerable aminic organoselenium antioxidants with cytoprotective effects	15
Metal-free three-component cyanoalkylation of quinoxalin-2(1H)-ones with vinylarenes and azobis(alkylcarbonitrile)s	15
Phenanthrenequinone (PQ) catalyzed cross-dehydrogenative coupling of alkanes with quinoxalin-2(1H)-ones and simple N-heteroarenes under visible light irradiation	15
A sustainable C–H functionalization of indoles, pyrroles and furans under a blue LED with iodonium ylides	15
Glucose conjugated aza-BODIPY for enhanced photodynamic cancer therapy	15
Photoinduced efficient synthesis of cyanoalkylsulfonylated oxindoles via sulfur dioxide insertion	15
Advances of α-activated cyclic isothiocyanate for the enantioselective construction of spirocycles	15
Reductive stability evaluation of 6-azopurine photoswitches for the regulation of CKIα activity and circadian rhythms	15
Asymmetric oxidative Mannich reactions promoted by photocatalysis and electrochemistry	15
Design, synthesis and biological evaluation of a halogenated phenazine-erythromycin conjugate prodrug for antibacterial applications	15
Recent advances in the tandem copper-catalyzed Ullmann–GoldbergN-arylation–cyclization strategies	15
Synthetic enzyme-catalyzed multicomponent reaction for Isoxazol-5(4H)-one Syntheses, their properties and biological application; why should one study mechanisms?	15
Binaphthyl–prolinol chiral ligands: design and their application in enantioselective arylation of aromatic aldehydes	15
Diaryliodonium(iii) salts in one-pot double functionalization of C–IIIIandorthoC–H bonds	15
Dissipative control of the fluorescence of a 1,3-dipyrenyl calix[4]arene in the cone conformation	15
Diversification of α-ketoamides via transamidation reactions with alkyl and benzyl amines at room temperature	15
Visible-light-promoted photocatalyst-free alkylation and acylation of benzothiazoles	15
Acid-catalyzed [2 + 2 + 2] cycloaddition of two cyanamides and one ynamide: highly regioselective synthesis of 2,4,6-triaminopyrimidines	15
Recent advances in C–H functionalization of 2H-indazoles	15
Copper-catalyzed ortho-selective direct sulfenylation of N-aryl-7-azaindoles with disulfides	15
Tricyclic 2-benzazepines obtained via an unexpected cyclization involving nitrilium ylides	15
Oxidative cross-coupling of thiols for S–X (X = S, N, O, P, and C) bond formation: mechanistic aspects	15
A sustainable photochemical aerobic sulfide oxidation: access to sulforaphane and modafinil	15
Electrochemical monofluoroalkylation cyclization ofN-arylacrylamides to construct monofluorinated 2-oxindoles	15
The construction of benzimidazo[2,1-a]isoquinolin-6(5H)-ones from N-methacryloyl-2-phenylbenzoimidazoles through radical strategies	15
Enantioselective N-heterocyclic carbene-catalysed intermolecular crossed benzoin condensations: improved catalyst design and the role of in situ racemisation	15
Recent strategies used in the synthesis of saturated four-membered heterocycles	15
I2-mediated coupling of quinazolinone enamines with 2-aminopyridines: a new strategy to access spiroquinazolinones	14
Chiroptical sensing of amino acids, amines, amino alcohols, alcohols and terpenes with π-extended acyclic cucurbiturils	14
Metal-free regioselective C–H amination for the synthesis of pyrazole-containing 2H-indazoles	14
An enantioselective aza-Friedel–Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines	14
Constructing firefly luciferin bioluminescence probes for in vivo imaging	14
Organocatalytic enantioselective aza-Friedel–Crafts reaction between benzothiazolimines and 2-naphthols for the preparation of chiral 2′-aminobenzothiazolomethyl naphthols	14
Contemporary advancements in the semi-synthesis of bioactive terpenoids and steroids	14
Iodonium ylides: an emerging and alternative carbene precursor for C–H functionalizations	14
Computational evidence of glycosyl cations	14
Diethylammonium iodide as catalyst for the metal-free synthesis of 5-aryl-2-oxazolidinones from aziridines and carbon dioxide	14
Recent advances in the functionalization of polyfluoro(aza)aromatics via C–C coupling strategies	14
N-Heterocyclic carbene (NHC)-catalyzed intramolecular benzoin condensation–oxidation	14
Application of combined cyanide sources in cyanation reactions	14
Copper-catalyzed [3 + 2]-cycloaddition of α-halonitroalkenes with azomethine ylides: facile synthesis of multisubstituted pyrrolidines and pyrroles	14
Synthetic and biosynthetic methods for selective cyclisations of 4,5-epoxy alcohols to tetrahydropyrans	14
Electrocatalytic three-component synthesis of 4-halopyrazoles with sodium halide as the halogen source	14
An air-stable, Zn2+-based catalyst for hydrosilylation of alkenes and alkynes	14
Antitumor activity of tridentate pincer and related metal complexes	14
Bismuth(iii) triflate as a novel and efficient activator for glycosyl halides	14
A novel near-infrared fluorescent probe based on isophorone for the bioassay of endogenous cysteine	14
A high-yielding solid-phase total synthesis of daptomycin using a Fmoc SPPS stable kynurenine synthon	14
Directmetasubstitution of calix[4]arenes	14
Catalyst-free synthesis of substituted pyridin-2-yl, quinolin-2-yl, and isoquinolin-1-yl carbamates from the corresponding hetaryl ureas and alcohols	14
Transition metal-free formal hydro/deuteromethylthiolation of unactivated alkenes	14
Dearomatization reaction of β-naphthols with disulfurating reagents	14
Electrochemical sulfonylation of enamides with sodium sulfinates to access β-amidovinyl sulfones	14