Organic & Biomolecular Chemistry

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Direct organocatalytic chemoselective synthesis of pharmaceutically active benzothiazole/benzoxazole-triazoles	55
Scalable synthesis of (±)-gregatin A via a 1,3-dipolar cycloaddition strategy	55
Fluorescence polarization assays to study carbohydrate–protein interactions	54
An efficient direct electrolysis method for the synthesis of 1,1,1,3,3,3-hexafluoroisopropyxy substituted imidazo[1,2-a]pyridines	50
Visible-light-promoted cascade cyclization of N-arylacrylamides with bromomethyl sulfone: access to sulfonylmethylated phenanthridines	48
I2-Catalyzed benzylation of NH-sulfoximines with diarylmethanes and alkylarenes	46
Synthesis of nonaromatic [16]thiatriphyrin(2.2.1)s	46
Design and synthesis of fluorescent-dye-labeled nucleotide with a new cleavable azo linker for DNA sequencing by synthesis	42
Diastereoselective thia-[3 + 2] cyclization of acetylpyranuloses and β-oxodithioesters	41
Overcoming the ring tension: computational approaches to stereochemical assignments and geometrical insights in small heterocycles	40
Synthesis of N-methyl secondary amides via diboronic acid anhydride-catalyzed dehydrative condensation of carboxylic acids with aqueous methylamine	40
Syntheses of differentially fluorinated triazole-based 1-deoxysphingosine analogues en route to SphK inhibitors	39
Continuous-flow synthesis of carboxylic acids from alcohols via platinum and silicon dioxide-catalyzed hydrogen peroxide oxidation	38
DMTSF-mediated electrophilic cyclization for the synthesis of 3-thiomethyl-substituted benzo[b]furan derivatives	37
Recent advances in Ugi reaction and its post-transformation strategies for crafting diverse indole frameworks	35
Stabilization of optically inactive α-helices of peptidic foldamers through sequence control and i, i + 4 stapling	35
Sodium sulfide-promoted regiodefined redox condensation of o-nitroanilines with aryl ketones to benzo[a]phenazines and quinoxalines	35
A metal-free synthesis of pyrimidines from amidines with α,β-unsaturated ketonesviatandem [3 + 3] annulation and visible-light-enabled photo-oxidation	34
Visible light-promoted intermolecular cyclization/aromatization of chalcones and 2-mercaptobenzimidazolesviaan EDA complex and a mechanism study	34
(NH4)2S2O8 promoted tandem radical cyclization of quinazolin-4(3H)-ones with oxamic acids for the construction of fused quinazolinones under metal-fr	34
The supramolecular chemistry of anions	34
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Palladium-catalyzed α-arylation of sulfoxonium ylides with aryl fluorosulfates	33
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Conversion of amino-terephthalonitriles to multi-substituted single benzene fluorophores with utility in bioimaging	33
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The synthesis of alk-2-ynl Weinreb amides via Pd/Cu-catalysed oxidative carbonylation of terminal alkynes	27
Chimeric GFP–uracil based molecular rotor fluorophores	27
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Direct β-C–H ketoalkylation of enaminoesters with cyclopropanols under metal-free conditions	25
Deoxygenative coupling of alcohols with aromatic nitriles enabled by direct visible light excitation	25
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Light-induced ligand-to-metal charge transfer of Fe(iii)-OR species in organic synthesis	25
Electrochemical alkylation of C(sp2)–H bonds via halogen-atom transfer (XAT) from alkyl iodides	25
Genome mining and heterologous expression reveal streptacidin, a new lasso peptide from Streptacidiphilus jiangxiensis	24
An unprecedented double photoexcitation mechanism for photoswitching in conjugated-dienes to trigger physiological processes for photopharmacology	24
Nickel(ii)-hydrazineylpyridine catalyzed regioselective synthesis of α-benzyl substituted β-hydroxy ketones via a Fenton free radical reaction	24
Tunable base-controlled chemoselective synthesis of trifluoromethyl-containing N-substituted benzimidazole-2-thiones and monofluorinated 4H-benzo[4,5]imidazo[2,1-b][1,3]thiazine	24
Photoinduced radical cyclization reaction of isocyanides with α-carbonyl bromides to access 11-alkyl-substituted 1,4-dibenzodiazepines	24
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Diastereoselective β-hydroxy vinylsulfone isomerizations	24
Synthesis of benzouracils and carbamates from chloroacetamides through carbon–carbon bond cleavage	24
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Outstanding Reviewers for Organic & Biomolecular Chemistry in 2022	20
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Macrocyclic versus open-chain carbazole receptors for carboxylate binding	19
Theoretical insights into the enantiodivergence induced by chiral phosphoric acid catalysis with a Lewis acid for the synthesis of N–N axially chiral atropisomers	19
Base-mediated synthesis of ring-fluorinated imidazo[1,2-a]pyridines via sequential C–F substitutions	19
Flexible and rigid “chirally distorted” π-systems: binaphthyl conjugates as organic CPL-active chromophores	19
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Recent progress in the homogeneous gold-catalysed cycloisomerisation reactions	19
HFIP-promoted phosphorylation of indol-3-yl methanols to access (indol-3-yl)methyl phosphonates	19
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Structure-activity relationship and bioactivity studies of neurotrophic trans-banglene	19
Diastereoselective three-component 1,3-dipolar cycloaddition: concise synthesis of functionalized tetrahydrocarboline-fused spirooxindoles	19
Reagent-assisted regio-divergent cyclization synthesis of pyrazole	19
Anion recognition by silanetriol in acetonitrile	18
Synthesis of functionalized S-benzyl dithiocarbamates from diazo-compounds via multi-component reactions with carbon disulfide and secondary amines	18
Organic acid catalysed Minisci-type arylation of heterocycles with aryl acyl peroxides	18
Radical-mediated sulfonylative/thiolative cyclization of biaryl enones to phenanthrone derivatives	18
Switchable C2/C3 positional selectivity of thioisatins in a three-component domino reaction: combined computational and experimental studies	18
Mechanochemical arylative detrifluoromethylation of trifluoromethylarenes	18
Fluoride ion coordination-induced turn-on fluorescence of tailoredN-methyl N-confused tripyrromonomethene analogues	18
t-BuOLi promoted regioselective N-thiolation of indoles with N-arylthio phthalimide	18
Modular synthesis of 3,3-disubstituted oxindoles from nitrones and acrylic acids	18
Recent applications of nanoparticles in organic transformations	18
Catalytic, asymmetric azidations at carbonyls: achiral and meso-anhydride desymmetrisation affords enantioenriched γ-lactams	18
Regioselective access to di- and trisubstituted pyridines via a metal-oxidant-solvent-free domino reaction involving 3-chloropropiophenones	18
Simplified hybrids of two anticancer bistetrahydroisoquinoline alkaloids ecteinascidin 743 and cribrostatin 4 and inhibitory activity against proliferation of cancer cells	18
ortho-Nitro-substituted diaryliodonium salts enabled regioselective cyclization of arylcarboxylic acids toward 3,4-naphthocoumarins	17
Magnesium catalyzed [3 + 3] heteroannulation of α-enolic dithioesters with MBH acetate: access to functionalized 3,4-dihydro-2H-thiopyrans	17
The catalytic decarboxylative allylation of enol carbonates: the synthesis of enantioenriched 3-allyl-3′-aryl 2-oxindoles and the core structure of azonazine	17
Silver-mediated radical oxytrifluoromethylation of unsaturated carboxylic acids for the synthesis of γ-trifluoromethylthio lactones	17
Theoretical mechanistic insights into the electrophilic addition of hydrogen halides to alkynes	17
Palladium nanoparticle catalyzed synthesis of indoles via intramolecular Heck cyclisation	17
Cationic gold(i)-catalyzed glycosylation with glycosyl N-1,1-dimethylpropargyl carbamate donors	17
Electrocatalytic three-component synthesis of 4-halopyrazoles with sodium halide as the halogen source	17
Synthesis of oxetane and azetidine ethers as ester isosteres by Brønsted acid catalysed alkylation of alcohols with 3-aryl-oxetanols and 3-aryl-azetidinols	17
Polymeric nanostructures based on azobenzene and their biomedical applications: synthesis, self-assembly and stimuli-responsiveness	17
Yb(OTf)3 catalyzed [1,3]-rearrangement of 3-alkenyl oxindoles	17
Photoredox-catalysed regioselective synthesis of C-4-alkylated pyridines with N-(acyloxy)phthalimides	16
Readily accessible azido-alkyne-functionalized monomers for the synthesis of cyclodextrin analogues using click chemistry	16
Synthesis of non-anomeric C-glycosyl pyrazolidinone derivatives via visible-light photoredox catalysis	16
Deploying solid-phase synthesis to access thymine-containing nucleoside analogs that inhibit DNA repair nuclease SNM1A	16
Four- and two-armed hetero porphyrin dimers: their specific recognition and self-sorting behaviours	16
Development of fluorophoric [2]pseudorotaxanes and [2]rotaxane: selective sensing of Zn(ii)	16
Regio- and stereoselective synthesis of functionalized and fused heterocycles from Morita–Baylis–Hillman adducts of dicyclopentadienone	16
Electrochemical oxidation of 3-substituted indoles	16
Azaborine benzylic ion stability and reactivity in ionic polymerization	16
Lipophilic glucose monoesters and glycosides are potent human Mincle agonists	16
Rh(iii)-Catalyzed C–H bond activation/annulation reactions of arylacyl ammonium salts with 4-diazoisochroman-3-imines and 4-diazoisoquinolin-3-ones	16
Synthesis of 3,4-dihydroxy-1,8-naphthalimides with inbuilt catechol and crown ether functionalities	16
Halogenation of aromatic compounds with N-halosuccinimides (NXS) catalysed by d-camphorsulfonic acid-BiCl3	16
Semisynthesis and antitumor activity of endertiin B and related triterpenoids from Ganoderma lucidum	16
Brønsted acid catalyzed [4 + 2] cycloaddition for the synthesis of bisbenzannulated spiroketals with antifungal activities	16
Synthesis of 4-trifluoromethyl-2H-chromenesviathe reaction of 2-(trifluoroacetyl)phenols with vinyltriphenylphosphonium chloride	16
Rapid, room-temperature self-organization of polyarylated 1H-pyrroles from acetylenes and nitriles in the KOBut/DMSO system	16
Longer fatty acid-protected GalNAz enables efficient labeling of proteins in living cells with minimized S-glyco modification	16
Advances in the synthesis of rearranged homoisoflavonoids	16
Mechanochemical asymmetric three-component Mannich reaction involving unreactive arylamines	16
Chromic properties of dibenzo[j,l]fluoranthenes exhibiting different resonance contributions	16
Parallel synthesis of oligonucleotides containing N-acyl amino-LNA and their therapeutic effects as anti-microRNAs	16
Iron-catalyzed alkoxyl radical-mediated C–C bond cleavage/phosphorothiolation: a new approach to functionalized S-alkyl phosphorothioates	16
The total synthesis of rhynchosporosides via orthogonal one-pot glycosylation and stereoselective α-glycosylation strategies	15
Palladium-catalyzed anti-Markovnikov oxidative acetalization of activated olefins with iron(iii) sulphate as the reoxidant	15
Regio- and stereoselective synthesis of tetrasubstituted (E)-(2-chloro-2-fluoro-1-iodovinyl)dimethylphenylsilane and its desilylative sonogashira coupling	15
PIFA-promoted intramolecular oxidative cyclization of pyrrolo- and indolo[1,2-a]quinoxalino-appended porphyrins: an efficient synthesis of meso,β-pyrrolo- and indolo[1,2-a]quinoxa	15

Photocatalyst-free hydroacylations of electron-poor alkenes and enones under visible-light irradiation	15
Palladium-catalysed Csp3–H functionalisation of unactivated 8-aminoquinoline amides in deep eutectic solvents	15
Synthesis of 7-hydroxydibenzopyran-6-ones via benzannulation of coumarins	15
A multi-modal probe for trace water and simultaneously monitoring lipid droplets and lysosomes	15
d-Mannose-appended 5,15-diazaporphyrin for photodynamic therapy	15
Synthesis of primary propargylic alcohols from terminal alkynes using rongalite as the C1 unit	15
Covalent nanosynthesis of fluorene-based macrocycles and organic nanogrids	15
A review on the assembly of multi-substituted pyridines via Co-catalyzed [2 + 2 + 2] cycloaddition with nitriles	15
Cu(ii)-catalyzed [4 + 1] and [4 + 3] annulation reactions: a modular approach to N-aryl/alkyl substituted 2,5-diamidopyrroles and diazepines	15
A metal-free tandem dehydrogenative α-arylation reaction of propargylic alcohols with 2-alkynylbenzaldoximes toward the synthesis of α-(4-bromo-isoquinolin-1-yl)-propenone skeletons	15
Julolidine-based small molecular probes for fluorescence imaging of RNA in live cells	15
A one-pot five component reaction for the synthesis of tetrazol-benzofuran hybrids and their inhibitory activity against Mucor lusitanicus	15
Visible-light-induced copper-catalyzed oxidative esterification of α-azidoketones with diazoacetates: access to α-acyloxyacetates	14
Cross dehydrogenation coupling reaction of purine derivatives with thioethers	14
Assembly of trifluoromethylated fused tricyclic pyrazoles via cyclization of β-amino cyclic ketones	14
Organic synthesis in flow mode by selective liquid-phase hydrogenation over heterogeneous non-noble metal catalysts	14
N-Alkylation of organonitrogen compounds catalyzed by methylene-linked bis-NHC half-sandwich ruthenium complexes	14
Regioselective Brønsted acid catalyzed ring opening of aziridines by phenols and thiophenols; a gateway to access functionalized indolines, indoles, benzothiazines, dihydrobenzo-thiazines, benzo-oxazi	14
Facile access to the 2,2-difluoro-2,3-dihydrofuran skeleton without extra additives: DMF-promoted difluorocarbene formation of ClCF2CO2Na	14
Recyclable and reusable ionic liquid-supported azo precursors in Mitsunobu reactions	14
Construction of benzoheterocycles by the reaction of α-arylglyoxylic acids and ortho-functionalized aniline under mild and minimal conditions	14
Photochemical direct alkylation of heteroarenes with alkanes, alcohols, amides, and ethers	14
Oxidative decarboxylative ammonium hypoiodite-catalysed dihydrobenzofuran synthesis	14
Vancomycin mimicry: towards new supramolecular antibiotics	14
Kinetic study of the reaction of thiophene-tocopherols with peroxyl radicals enlightenings the role of O˙⋯S noncovalent interactions in H-atom transfer	14
Photochemistry of 2-(2-formylphenyloxy)acetic acid derivatives: synthesis of hydroxychromanones and benzofuranones	14
Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins	14
Total synthesis of proposed elgonene C and its (4R,5R)-diastereomer	14
Palladium-catalyzed cascade Heck-type cyclization and reductive aminocarbonylation for the synthesis of functionalized amides	14
COS-triggered oxygen/sulfur exchange of isatins: chemoselective synthesis of functionalized isoindigos and spirothiopyrans via self-condensation and the thio-Diels–Alder reaction	14
Ce-catalyzed regioselective synthesis of pyrazoles from 1,2-diols via tandem oxidation and C–C/C–N bond formation	14
Progressive study on ruthenium catalysis for de(hydrogenative) alkylation and alkenylation using alcohols as a sustainable source	14
The Cloke–Wilson rearrangement of aroyl-substituted donor–acceptor cylopropanes containing arylethyl donors	14
Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors	14
Microwave-assisted palladium catalysed C–H acylation with aldehydes: synthesis and diversification of 3-acylthiophenes	13
Dithioallyl cation (3 + 2) cycloadditions under aprotic reaction conditions: rapid access to spiro-fused cyclopentane scaffolds	13
A metal-free strategy for the cross-dehydrogenative coupling of 1,3-dicarbonyl compounds with 2-methoxyethanol	13
Progress in copper-catalysed/mediated intramolecular dehydrogenative coupling	13
Access to α,α-difluoro(arylthio)methyl oxetanes from α,α-difluoro(arylthio)methyl ketones and trimethylsulfoxonium halides: scope, mechanism and applications	13
Microwave-assisted annulation for the construction of pyrido-fused heterocycles and their application as photoluminescent chemosensors	13
N-Functionalized fluorophores: detecting urinary albumin and imaging lipid droplets	13
An efficient and straightforward approach for accessing thionoesters via palladium-catalyzed C–N cleavage of thioamides	13
Alkylation of isatins with trichloroacetimidates	13
Copper-mediated synthesis of fullerooxazoles from [60]fullerene and N-hydroxybenzimidoyl cyanides	13
Antifungal mono- and dimeric nitrogenous bisabolene derivatives from a sponge in the order Bubarida from Futuna Islands	13
Combination of gold and redox enzyme catalysis to access valuable enantioenriched aliphatic β-chlorohydrins	13
Development of a synthetic equivalent of α,α-dicationic acetic acid leading to unnatural amino acid derivatives via tetrafunctionalized methanes	13
Copper-catalyzed cascade reaction of tryptamines with diazo compounds to access hexahydropyrroloindoline derivatives	13
Unexpected dearomatization of N-protected 5-aminopyrazoles at ambient temperature: a simple route to highly functionalized pyrazolines	13
Alkali metal hydroxide-catalyzed mechanisms of Csp–H silylation of alkynes: a DFT investigation	13
Synthesis of the matriglycan hexasaccharide, -3Xylα1-3GlcAβ1-trimer and its interaction with laminin	13
Copper-catalyzed aerobic annulation of hydrazones with dienones: an efficient route to pyrazole-linked hybrid molecules	13
One-pot formal [3 + 2] annulation of 2-pyridinyl-substituted p-quinone methides and arynes for the synthesis of 3-aryl pyrido[1,2-a]indoles	13
An iron-catalyzed domino reaction of donor–acceptor cyclopropanes: a diastereoselective approach towards diversely functionalized pyrrolo-quinazolines	13
Chemoselective, osmium-free, dihydroxylation/oxidative cleavage of heteroaryl isoprenes by a contemporary Malaprade reaction	13
Methyl group configuration on acyclic threoninol nucleic acids (aTNAs) impacts supramolecular properties	13
Microwave-assisted direct synthesis of BODIPY dyes and derivatives	13
Decyanation–(hetero)arylation of malononitriles to access α-(hetero)arylnitriles	13
Brønsted acid-promoted synthesis of highly functionalized tetrahydrocarbazoles from diethyl (E)-5-diazo-4-oxohex-2-enedioate	13
Metal-free efficient synthesis of aryl sulfonamides from N-hydroxy sulfonamide and amines	13
Synthesis and rotational dynamics of diazamacrocycles having bridged 1,4-naphthylene as framed molecular rotors	13
Porous materials formed by four self-construction processes	13
Chemoselective cycloadditions to epoxide derivatives of erucic acid with CO2and CS2: controlled access to value-added bio-derived compounds	13
A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function	13
Progress toward a biomimetic synthesis of pegaharmaline A	13
Facile construction of C,N-disulfonated 5-amino pyrazoles through an iodine-catalyzed cascade reaction	13
Synthesis of 3-sulfonylisoindolin-1-ones from olefinic amides and sodium sulfinates via electrooxidative tandem cyclization	13
Indoline hemiaminals: a platform for accessing anthranilic acid derivatives through oxidative deformylation	13
Palladium-catalyzed Heck-carbonylation of alkene-tethered carbamoyl chlorides with aryl formates	12
C5-pyrimidine-functionalized morpholino oligonucleotides exhibit differential binding affinity, target specificity and lipophilicity	12
MnSO4-promoted S–O bond cleavage for synthesizing functionalized sulfonium ylides from activated alkynes and sulfoxides	12
Direct C–H borylation of vinylporphyrins via copper catalysis	12
Synthesis of substituted norcaranes for use as probes of enzyme mechanisms	12
Stereoselective synthesis of the northern hemisphere of the proposed structure of neaumycin B	12
Cycloaddition of N-arylnitrones with donor–acceptor oxiranes via C–C bond cleavage to construct 1,5,2-dioxazinanes	12
Design and synthesis of a tetracyclic tripeptide mimetic frozen in a polyproline type II (PP2) helix conformation	12
Thapsigargin: a promising natural product with diverse medicinal potential – a review of synthetic approaches and total syntheses	12
New reagent space and new scope for the Castagnoli–Cushman reaction of oximes and 3-arylglutaconic anhydrides	12
Butterflyene: an entry into an aesthetically pleasing carbocycle via a Diels–Alder reaction on a tetrasubstituted olefin	12
Metal-free oxidative formal C(sp2)–H arylation of cyclopentene-1,3-diones with β-naphthols	12
Supramolecular polyplexes from Janus peptide nucleic acids (bm-PNA-G5): self-assembled bm-PNA G-quadruplex and its tetraduplex with DNA	12
Synthesis of novel C-nucleoside analogues bearing an anomeric cyano and a 1,2,3-triazole nucleobase as potential antiviral agents	12
Trace water in a BF3·OEt2 system: a facile access to sulfinyl alkenylsulfones from alkynes and sodium sulfinates	12
A new phosphoramidite enables orthogonal double labelling to form combination oligonucleotide probes	12
Design of substituted tetrahydrofuran derivatives for HIV-1 protease inhibitors: synthesis, biological evaluation, and X-ray structural studies	12
Transition-metal-free and additive-free intermolecular hydroarylation of alkenes with indoles in hexafluoroisopropanol	12
Copper(ii)-catalyzed, site-selective C(sp)2–H amination using 8-aminoimidazo[1,2-a]pyridine (8-AIP) as a directing group	12
BiCl3 catalyzed synthesis of 2-amino-1,4-naphthoquinones and 1,4-naphthoquinon-2-sulfides and one-pot sequential amine-arylation of 1,4-naphthoquinone	12
Rapid paper-based optical sensing of Spilosoma obliqua nucleopolyhedrovirus via ester hydrolysis	12
Enantioselective Lewis base catalysed allylation of picoline- and quinaldine-based latent pronucleophiles	12
Rh(ii)-catalyzed Doyle–Kirmse reaction: access to unprotected 3-allyl/3-allenyl-3-(thio)oxindoles	12
Direct formylation of phenols using difluorocarbene as a safe CO surrogate	12
Cascade cyclization for the synthesis of indolo[2,1-α]isoquinoline derivatives via visible-light-induced halogen-atom-transfer (XAT) and hydrogen-atom-transfer (HAT)	12
Enzyme directed evolution using genetically encodable biosensors	12
Palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the assembly of dihydrodibenzo[b,d]oxepines	12