OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Nanobiotechnology is 90. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Double-layered N-S1 protein nanoparticle immunization elicits robust cellular immune and broad antibody responses against SARS-CoV-2	300
Self-disassembling diatomic nanocluster bomb unlock reciprocal synergistic multi-pathway cancer therapy	286
Correction: Bacterial outer membrane vesicle-cancer cell hybrid membrane-coated nanoparticles for sonodynamic therapy in the treatment of breast cancer bone metastasis	274
Multifunctional nanoagonist enhances photodynamic therapy-driven in situ cancer vaccination by inhibiting tumor thrombosis	274
Correction: Conductive single-wall carbon nanotubes/extracellular matrix hybrid hydrogels promote the lineage-specific development of seeding cells for tissue repair through reconstructing an integrin	257
Design and mechanistic insights into ZMF59/CpG: a complementary adjuvant system boosting immunity and safety in herpes zoster vaccines	251
H2S-responsive CuSe nanoparticles convert into CuSSe in situ with band gap modulation for oxygen self-supply and enhanced colon cancer phototherapy	241
Visualization of photothermal therapy by semiconducting polymer dots mediated photoacoustic detection in NIR II	235
Engineering BiTE-inspired IPSC-exosomes to potentiate CAR-T cell therapy against lung cancer	230
Multifunctional copper-based nanoparticles potentiate colorectal cancer immunotherapy via synergistic metabolic remodeling and cGAS-STING pathway activation	227
Maternal exposure to fullerenols impairs placental development in mice by inhibiting estriol synthesis and reducing ERα	221
Assembling Au8 clusters on surfaces of bifunctional nanoimmunomodulators for synergistically enhanced low dose radiotherapy of metastatic tumor	220
A clinically feasible circulating tumor cell sorting system for monitoring the progression of advanced hepatocellular carcinoma	208
Pathogen-microenvironment-responsive and antioxidant-buffered propiconazole nanofungicide for safe and effective fungal disease control	207
Tumor-activated dual metabolic nanomodulator turns over tolerogenic tumor control and unleashes systemic immune responses	183
Exosomes from umbilical cord-derived mesenchymal stem cells combined with gelatin methacryloyl inhibit vein graft restenosis by enhancing endothelial functions	182
Neutrophil-guided pro-efferocytic mRNA platform for accelerated diabetic wound repair	181
Immune-modified exosome vaccine loaded with liver cancer epitope peptides induces potent and specific antitumor immunity	180
Targeting CAD with a tumor microenvironment-responsive nano-heterojunction for synergistic induction of cuproptosis and inhibition of colorectal cancer progression	178
Nanocomposites based on nanoceria regulate the immune microenvironment for the treatment of polycystic ovary syndrome	176
Microneedle delivery system with rapid dissolution and sustained release of bleomycin for the treatment of hemangiomas	174
Eriodictyol-cisplatin coated nanomedicine synergistically promote osteosarcoma cells ferroptosis and chemosensitivity	171
Apoptotic extracellular vesicles act as master regulators of the bone healing niche	168
An exosomal strategy for targeting cancer-associated fibroblasts mediated tumors desmoplastic microenvironments	165
A multifunctional ICAM1-directed MnO₂@ZIF8 nanoplatform with Tanshinone IIA synergistically reverses senescence and restores alveolar regeneration in septic lung injury	165

Cartilage targeting therapy with reactive oxygen species-responsive nanocarrier for osteoarthritis	163
Biomimetic β-lapachone and hemin nanoassembly for intracellular oxidation cascade amplified ferroptosis in hepatocellular carcinoma therapy	161
Nanoplastics-mediated physiologic and genomic responses in pathogenic Escherichia coli O157:H7	156
Self-activated prodrug nanocomposites reprogramming lactic acid metabolism to initiate acidosis-endoplasmic reticulum stress cascade and potentiate immunogenic cell death for enhanced liver cancer the	154
Glutathione responsive iNOS inhibiting polymeric prodrug for targeted Inhibition of angiogenesis	151
Macrophage membrane (MMs) camouflaged near-infrared (NIR) responsive bone defect area targeting nanocarrier delivery system (BTNDS) for rapid repair: promoting osteogenesis via phototherapy and modula	150
Customizing cancer treatment at the nanoscale: a focus on anaplastic thyroid cancer therapy	142
Dual-function TA@CaCO3 nanomedicine targeting M2 macrophage lipid peroxidation sensitivity in rheumatoid arthritis therapy	138
MXene-based nanosheet for enhanced glioma therapy via photonic hyperthermia to boost the abscopal effect of radioimmunotherapy	138
Mesoporous multimetallic PdPtBi nanozymes target redox imbalance and glutamine deprivation for immuno-chemodynamic therapy	137
Transdermal delivery of CRISPR/Cas9-mediated melanoma gene therapy via polyamines-modified thermosensitive hydrogels	137
BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma	134
3D printed shape-memory piezoelectric scaffolds with in-situ self-power properties for bone defect repair	134
Nanomedicine's shining armor: understanding and leveraging the metal-phenolic networks	133
A high-affinity CEA-targeted nanobody for 68Ga PET imaging and 177Lu-based radioisotope therapy: preclinical and first-in-human evaluation	133
Exosomes: compositions, biogenesis, and mechanisms in diabetic wound healing	130
Immunomodulating melatonin-decorated silica nanoparticles suppress bacterial wilt (Ralstonia solanacearum) in tomato (Solanum lycopersicum L.) through fine-tuning of oxidative signaling and rhizospher	128
A sequentially targeted and pathology-responsive nanoplatform for synergistic treatment of dry eye disease via concurrent anti-inflammation and mitochondrial ROS scavenging	126
New anti-cancer explorations based on metal ions	125
Gut-derived extracellular vesicle enriched miR-125a-5p mediates cadmium-induced intestinal injury through NF-κB pathway activation	122
Integrated triple signal amplification strategy for ultrasensitive electrochemical detection of gastric cancer-related microRNA utilizing MoS2-based nanozyme, hybridization chain reaction, and horsera	121
Curcumin-loaded copper/iron bimetallic nanoparticle-incorporated hydrogel scaffold: a sequential microenvironment reprogramming platform for accelerated chronic wound healing	120
An encounter between metal ions and natural products: natural products-coordinated metal ions for the diagnosis and treatment of tumors	120
Biocompatible exosome-modified fibrin gel accelerates the recovery of spinal cord injury by VGF-mediated oligodendrogenesis	118
Piezoelectric heterojunction/polyetherketoneketone composite with enhanced sonodynamic efficacy and nanozyme activities for anti-infection and encouraging neurovascular ossification	117
MnO2 and roflumilast-loaded probiotic membrane vesicles mitigate experimental colitis by synergistically augmenting cAMP in macrophage	117
Oxygen vacancy-engineered bimetallic nanozymes for disrupting electron transport chain and synergistic multi-enzyme activity to reverse oxaliplatin resistance in colorectal cancer	117
Multifunctional nanoagent for enhanced cancer radioimmunotherapy via pyroptosis and cGAS-STING activation	116
De novo strategy of organic semiconducting polymer brushes for NIR-II light-triggered carbon monoxide release to boost deep-tissue cancer phototheranostics	114
Hyaluronic acid-functionalized supramolecular nanophotosensitizers for targeted photoimmunotherapy of triple-negative breast cancer	114
Radionuclide-labeled oxygen-self-supplying calcium reservoir for high-efficiency radioimmunotherapy via synergistic pyroptosis activation and PD-L1 downregulation	113
An ESIPT-AIE nanosensor for ONOO− imaging: decoding heavy metal stress and ferroptosis in living plants	113
Oral administration of Sophora Flavescens-derived exosomes-like nanovesicles carrying CX5461 ameliorates DSS-induced colitis in mice	111
Harnessing protein sensing ability of electrochemical biosensors via a controlled peptide receptor–electrode interface	109
Co-delivery of axitinib and PD-L1 siRNA for the synergism of vascular normalization and immune checkpoint inhibition to boost anticancer immunity	108
Dephosphorylation-regulated MNAzyme-PER cascade as a programmable converter for multi-task molecular actuation	108
Macrophage membrane-camouflaged biomimetic nanoparticles for rheumatoid arthritis treatment via modulating macrophage polarization	108
DNAzyme hydrogels specifically inhibit the NLRP3 pathway to prevent radiation-induced skin injury in mice	104
Fusiform nanoparticle boosts efficient genetic transformation in Sclerotinia sclerotiorum	103
Recent progress of non-linear topological structure polymers: synthesis, and gene delivery	103
Recent advances of metal-based nanoparticles in nucleic acid delivery for therapeutic applications	101
A novel nanosensor for in situ detection of EV-miR-107 enables noninvasive tuberculosis diagnosis and treatment monitoring	101
Green synthesis of glyco-CuInS2 QDs with visible/NIR dual emission for 3D multicellular tumor spheroid and in vivo imaging	100
Nanotechnology for research and treatment of the intestine	99
An oxygen-generating nanoplatform remodels the immunosuppressive tumor microenvironment via synergistic lactate depletion and sonodynamic therapy	99
CPA-Cas12a-based lateral flow strip for portable assay of Methicillin-resistant Staphylococcus aureus in clinical sample	99
High-throughput synthesis and optimization of ionizable lipids through A3 coupling for efficient mRNA delivery	97
Protective effect of spore oil-functionalized nano-selenium system on cisplatin-induced nephrotoxicity by regulating oxidative stress-mediated pathways and activating immune response	97
The nucleic acid reactions on the nanomaterials surface for biomedicine	95
αvβ3 integrin-specific exosomes engineered with cyclopeptide for targeted delivery of triptolide against malignant melanoma	95

Design of a new electrochemical aptasensor based on screen printed carbon electrode modified with gold nanoparticles for the detection of fumonisin B1 in maize flour	94
Structural optimization of Sr/Zn-phosphate conversion coatings triggered by ions preloading on micro/nanostructured titanium surfaces for bacterial infection control and enhanced osteogenesis	94
Targeting and repolarizing M2-like tumor-associated macrophage-mediated MR imaging and tumor immunotherapy by biomimetic nanoparticles	94
Gold-nanosphere mitigates osteoporosis through regulating TMAO metabolism in a gut microbiota-dependent manner	94
A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression	93
Gouqi-derived nanovesicles (GqDNVs) inhibited dexamethasone-induced muscle atrophy associating with AMPK/SIRT1/PGC1α signaling pathway	93
Engineered extracellular vesicles-mediated curcumin delivery in brain microenvironment modulating lysosomes, mitochondria, and microglia reprogram for parkinson’s disease therapy	93
Intestinal nanoparticle delivery and cellular response: a review of the bidirectional nanoparticle-cell interplay in mucosa based on physiochemical properties	93
Inorganic nanoparticle-based treatment approaches for colorectal cancer: recent advancements and challenges	92
The current status of stimuli-responsive nanotechnologies on orthopedic titanium implant surfaces	92
PDGFR-α shRNA-polyplex for uveal melanoma treatment via EMT mediated vasculogenic mimicry interfering	91
Lipid liquid-crystalline nanoparticles as a suitable platform for accommodating sensitive membrane proteins: monitoring the activity of HMG-CoA reductase	91
NK-92 cells labeled with Fe3O4-PEG-CD56/Avastin@Ce6 nanoprobes for the targeted treatment and noninvasive therapeutic evaluation of breast cancer	91
Correction: Regulation of immune microenvironments by polyetheretherketone surface topography for improving osseointegration	91
CT-sensitized nanoprobe for effective early diagnosis and treatment of pulmonary fibrosis	90
Expression of Concern: Curcumin- and resveratrol-co-loaded nanoparticles in synergistic treatment of hepatocellular carcinoma	90