OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Communication and Signaling is 61. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Genetic screening for anticancer genes highlights FBLN5 as a synthetic lethal partner of MYC	477
The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor	430
Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation	369
Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation	288
Caffeine mitigates ROS accumulation and attenuates motor neuron degeneration in the wobbler mouse model of amyotrophic lateral sclerosis	269
Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2	245
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases	241
Tannic acid inhibits TNF-α signaling by targeting the protein disulfide isomerase and alleviates symptoms in an imiquimod-induced psoriasis mouse model	213
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress	199
Polydatin upregulates ZDHHC19 to promote apoptosis of acute myeloid leukemia cells via mediating BID palmitoylation	175
Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-naïve cells	168
Epigenetic regulation of NR5A2 influences colorectal cancer cell stemness via a stemness-related transcription factor NANOG	166
The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells	161
Epigenetic meets metabolism: novel vulnerabilities to fight cancer	150
Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis	132
Catalase-deficient mice induce aging faster through lysosomal dysfunction	131
Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury	126
MSP-RON signaling in liver pathobiology and as an emerging therapeutic target: a review of the current evidence	124
Transmission Electron Microscopy-based characterization of Extracellular Vesicles from plasma and serum from Parkinson´s Disease patients	120
The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice	116
miR-23b-3p, miR-126-3p and GAS5 delivered by extracellular vesicles inhibit breast cancer xenografts in zebrafish	112
UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1	107
Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage	103
Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer	103
A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types	103

RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma	100
Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis	99
USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice	98
RNA N6-methyladenosine modification in female reproductive biology and pathophysiology	98
Mitochondrial dysfunction in the regulation of aging and aging-related diseases	98
SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells	95
Phase separation-mediated biomolecular condensates and their relationship to tumor	94
STAT3 blockade ameliorates LPS-induced kidney injury through macrophage-driven inflammation	94
New insights into the regulation of METTL3 and its role in tumors	89
Recent advances in the roles of exosomal microRNAs (exomiRs) in hematologic neoplasms: pathogenesis, diagnosis, and treatment	87
The scaffold protein AXIN1: gene ontology, signal network, and physiological function	81
Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases	81
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis	80
The role of lactate in cardiovascular diseases	80
Soluble E-cadherin contributes to inflammation in acute lung injury via VEGF/VEGFR2 signaling	78
LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence	76
Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression	76
Proteomic analysis of hydrogen peroxide-treated human chondrocytes shows endoplasmic reticulum stress, cytoskeleton remodeling, and altered secretome composition	75
Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges	74
Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2	73
Correction: LOX overexpression programming mediates the osteoclast mechanism of low peak bone mass in female offspring rats caused by pregnant dexamethasone exposure	73
LRSAM1 mediated the degradation of intracellular Vibrio through the ubiquitination-autophagy-lysosome pathway in oyster	73
MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis	72
IL-23 promotes neuronal ferroptosis via IL-23R/STAT3 signaling after traumatic brain injury	71
HAX1 inhibits apoptosis and promotes maturation of neutrophils	71
Correction: Anastasis: cell recovery mechanisms and potential role in cancer	70
Dual inhibition of GTP-bound KRAS and mTOR in lung adenocarcinoma and squamous cell carcinoma harboring KRAS G12C	69
TGFβ1-induced hedgehog signaling suppresses the immune response of brain microvascular endothelial cells elicited by meningitic Escherichia coli	69
Correction: The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities	69
The primary cilium as a multifunctional organelle: emerging roles and unanswered questions	68
Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction	68
E3 ubiquitin ligase RNF128 negatively regulates the IL-3/STAT5 signaling pathway by facilitating K27-linked polyubiquitination of IL-3Rα	66
Evidence that CRISPR-Cas9 Y537S-mutant expressing breast cancer cells activate Yes-associated protein 1 to driving the conversion of normal fibroblasts into cancer-associated fibroblasts	65
Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress	64
Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells	63
Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease	62
Role of DEAD/DEAH-box helicases in immunity, infection and cancers	61
Correction: Human Parathyroid Hormone Analog (3–34/29–34) promotes wound re-epithelialization through inducing keratinocyte migration and epithelial–mesenchymal transition via PTHR1-PI3K/AKT activatio	61