OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Communication and Signaling is 50. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Genetic screening for anticancer genes highlights FBLN5 as a synthetic lethal partner of MYC	394
The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells	299
Epigenetic meets metabolism: novel vulnerabilities to fight cancer	266
miR-23b-3p, miR-126-3p and GAS5 delivered by extracellular vesicles inhibit breast cancer xenografts in zebrafish	213
The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor	181
A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types	181
Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-naïve cells	175
Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury	174
Extracellular vesicles from maternal uterine cells exposed to risk factors cause fetal inflammatory response	160
Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage	143
Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2	138
Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation	126
USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice	122
Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis	119
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases	108
Proteomic analysis of hydrogen peroxide-treated human chondrocytes shows endoplasmic reticulum stress, cytoskeleton remodeling, and altered secretome composition	99
Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2	93
Recent advances in the roles of exosomal microRNAs (exomiRs) in hematologic neoplasms: pathogenesis, diagnosis, and treatment	93
The scaffold protein AXIN1: gene ontology, signal network, and physiological function	90
Phase separation-mediated biomolecular condensates and their relationship to tumor	89
The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice	88
RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma	87
Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer	86
Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation	82
Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis	81

UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1	78
Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases	78
STAT3 blockade ameliorates LPS-induced kidney injury through macrophage-driven inflammation	76
Mitochondrial dysfunction in the regulation of aging and aging-related diseases	76
LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence	74
RNA N6-methyladenosine modification in female reproductive biology and pathophysiology	72
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis	70
Catalase-deficient mice induce aging faster through lysosomal dysfunction	70
New insights into the regulation of METTL3 and its role in tumors	67
Soluble E-cadherin contributes to inflammation in acute lung injury via VEGF/VEGFR2 signaling	67
SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells	63
The role of lactate in cardiovascular diseases	61
Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression	60
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress	59
LRSAM1 mediated the degradation of intracellular Vibrio through the ubiquitination-autophagy-lysosome pathway in oyster	59
Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges	59
Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction	57
O-GlcNAcylation: roles and potential therapeutic target for bone pathophysiology	56
Nanobodies and their derivatives: pioneering the future of cancer immunotherapy	56
Intrauterine administration of peripheral blood mononuclear cells helps manage recurrent implantation failure by normalizing dysregulated gene expression including estrogen-responsive genes in mice	56
Increased levels of villus-derived exosomal miR-29a-3p in normal pregnancy than uRPL patients suppresses decidual NK cell production of interferon-γ and exerts a therapeutic effect in abortion-prone m	55
The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis	54
TGF-β1 regulates chondrocyte proliferation and extracellular matrix synthesis via circPhf21a-Vegfa axis in osteoarthritis	51
NAT10 mediated ac4C acetylation driven m6A modification via involvement of YTHDC1-LDHA/PFKM regulates glycolysis and promotes osteosarcoma	51
IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways	50
Roles of Twist1 in lipid and glucose metabolism	50
IL-23 promotes neuronal ferroptosis via IL-23R/STAT3 signaling after traumatic brain injury	50