OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Communication and Signaling is 67. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor	567
Harnessing nanomedicine to target NF-κB signalling in cancer: at the intersection of inflammatory signalling, metabolic reprogramming, and therapeutic innovation	538
The scaffold protein AXIN1: gene ontology, signal network, and physiological function	349
The p53 tumor suppressor modulates the expression of proteins that control natural killer cell activity	337
Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2	322
Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage	313
LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence	258
Caffeine mitigates ROS accumulation and attenuates motor neuron degeneration in the wobbler mouse model of amyotrophic lateral sclerosis	229
Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer	226
Primary ciliogenesis is promoted during epithelial-mesenchymal transition via a miR-200 – DZIP1 axis	196
Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression	190
Transmission Electron Microscopy-based characterization of Extracellular Vesicles from plasma and serum from Parkinson´s Disease patients	170
Soluble E-cadherin contributes to inflammation in acute lung injury via VEGF/VEGFR2 signaling	155
Polydatin upregulates ZDHHC19 to promote apoptosis of acute myeloid leukemia cells via mediating BID palmitoylation	143
Recent advances in the roles of exosomal microRNAs (exomiRs) in hematologic neoplasms: pathogenesis, diagnosis, and treatment	143
Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury	141
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases	138
RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma	134
Proteomic analysis of hydrogen peroxide-treated human chondrocytes shows endoplasmic reticulum stress, cytoskeleton remodeling, and altered secretome composition	133
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis	132
Mitochondrial dysfunction in the regulation of aging and aging-related diseases	132
The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells	127
The role of lactate in cardiovascular diseases	127
Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-naïve cells	125
Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases	114

The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice	113
Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis	113
Catalase-deficient mice induce aging faster through lysosomal dysfunction	112
STAT3 blockade ameliorates LPS-induced kidney injury through macrophage-driven inflammation	109
Exosome RAB10 inhibits JAK1/STAT1 to hinder macrophage M1 polarization and promote tumor immune escape	104
Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2	104
Genetic screening for anticancer genes highlights FBLN5 as a synthetic lethal partner of MYC	99
Epigenetic regulation of NR5A2 influences colorectal cancer cell stemness via a stemness-related transcription factor NANOG	99
Interruption of cross-communication pathways alters the immune cell signature of pancreatic cancer and decreases tumor growth	97
Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis	96
RNA N6-methyladenosine modification in female reproductive biology and pathophysiology	96
UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1	96
Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation	93
SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells	90
Phase separation-mediated biomolecular condensates and their relationship to tumor	89
miR-23b-3p, miR-126-3p and GAS5 delivered by extracellular vesicles inhibit breast cancer xenografts in zebrafish	89
Tannic acid inhibits TNF-α signaling by targeting the protein disulfide isomerase and alleviates symptoms in an imiquimod-induced psoriasis mouse model	88
Chondroitin sulfate E activates IL-6/STAT3 signaling to drive androgen-independent growth in castration-resistant prostate cancer	87
RT–ICI therapy induces a distal immunometabolic axis that shapes systemic macrophage polarization and enhances local T cell immunity	86
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress	86
MSP-RON signaling in liver pathobiology and as an emerging therapeutic target: a review of the current evidence	85
Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation	83
Epigenetic meets metabolism: novel vulnerabilities to fight cancer	82
USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice	82
Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges	79
Non-canonical STING activation by calcium influx paired to endoplasmic reticulum stress	77
New insights into the regulation of METTL3 and its role in tumors	77
MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis	76
LRSAM1 mediated the degradation of intracellular Vibrio through the ubiquitination-autophagy-lysosome pathway in oyster	76
Fibroblast-derived POSTN promotes colorectal cancer progression under high-fat diet by reprogramming fatty acid metabolism in tumor cell	76
Signaling pathways, microenvironment, and targeted treatments in Langerhans cell histiocytosis	75
Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells	74
RepID represses megakaryocytic differentiation by recruiting CRL4A-JARID1A at DAB2 promoter	72
Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease	72
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer	71
Role of DEAD/DEAH-box helicases in immunity, infection and cancers	70
NAT10 mediated ac4C acetylation driven m6A modification via involvement of YTHDC1-LDHA/PFKM regulates glycolysis and promotes osteosarcoma	69
HAX1 inhibits apoptosis and promotes maturation of neutrophils	69
Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice	69
Mitochondria facilitate neuronal differentiation by metabolising nuclear-encoded RNA	68
Microglial depletion decreases Müller cell maturation and inner retinal vascular density	68
SIRT6 cooperates with KDM5C to transcriptionally silence MICAL2 and inhibit tumorigenesis in pancreatic cancer	68
Precise metabolomics identifies glycolysis-related pyruvate kinase M activity as regulator of the S-phase-specific radiation response in triple-negative breast cancer cells	67