OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Communication and Signaling is 58. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Genetic screening for anticancer genes highlights FBLN5 as a synthetic lethal partner of MYC	449
The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells	353
The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor	348
miR-23b-3p, miR-126-3p and GAS5 delivered by extracellular vesicles inhibit breast cancer xenografts in zebrafish	255
Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage	235
STAT3 blockade ameliorates LPS-induced kidney injury through macrophage-driven inflammation	225
Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation	206
The scaffold protein AXIN1: gene ontology, signal network, and physiological function	194
Phase separation-mediated biomolecular condensates and their relationship to tumor	175
Snail mediates GDF-8-stimulated human extravillous trophoblast cell invasion by upregulating MMP2 expression	156
Mitochondrial dysfunction in the regulation of aging and aging-related diseases	150
Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis	147
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress	141
The role of lactate in cardiovascular diseases	139
Connexin32 gap junction channels deliver miR155-3p to mediate pyroptosis in renal ischemia-reperfusion injury	116
Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation	110
Caffeine mitigates ROS accumulation and attenuates motor neuron degeneration in the wobbler mouse model of amyotrophic lateral sclerosis	109
MSP-RON signaling in liver pathobiology and as an emerging therapeutic target: a review of the current evidence	108
SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells	106
Transmission Electron Microscopy-based characterization of Extracellular Vesicles from plasma and serum from Parkinson´s Disease patients	106
LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence	103
Proteomic analysis of hydrogen peroxide-treated human chondrocytes shows endoplasmic reticulum stress, cytoskeleton remodeling, and altered secretome composition	98
Catalase-deficient mice induce aging faster through lysosomal dysfunction	93
Chemotherapy reprograms miRNA expression profiles in apoptotic extracellular vesicles from medulloblastoma cells, regulating pro- and anti-proliferative effects on recipient drug-naïve cells	92
Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2	91

UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1	89
New insights into the regulation of METTL3 and its role in tumors	89
Epigenetic meets metabolism: novel vulnerabilities to fight cancer	88
Soluble E-cadherin contributes to inflammation in acute lung injury via VEGF/VEGFR2 signaling	88
USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice	84
Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases	83
Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis	81
RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma	80
A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types	79
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases	78
Recent advances in the roles of exosomal microRNAs (exomiRs) in hematologic neoplasms: pathogenesis, diagnosis, and treatment	77
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis	71
The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice	70
Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2	68
Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer	68
RNA N6-methyladenosine modification in female reproductive biology and pathophysiology	67
TGF-β1 regulates chondrocyte proliferation and extracellular matrix synthesis via circPhf21a-Vegfa axis in osteoarthritis	66
LRSAM1 mediated the degradation of intracellular Vibrio through the ubiquitination-autophagy-lysosome pathway in oyster	66
Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1	66
Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges	66
MyD88 protein destabilization mitigates NF-κB-dependent protection against macrophage apoptosis	66
Correction: LOX overexpression programming mediates the osteoclast mechanism of low peak bone mass in female offspring rats caused by pregnant dexamethasone exposure	66
Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress	65
HAX1 inhibits apoptosis and promotes maturation of neutrophils	64
The diverse dependence of galectin-1 and -8 on multivalency for the modulation of FGFR1 endocytosis	63
Repurposing thioridazine for inducing immunogenic cell death in colorectal cancer via eIF2α/ATF4/CHOP and secretory autophagy pathways	62
IL-23 promotes neuronal ferroptosis via IL-23R/STAT3 signaling after traumatic brain injury	61
Correction: Anastasis: cell recovery mechanisms and potential role in cancer	61
TGFβ1-induced hedgehog signaling suppresses the immune response of brain microvascular endothelial cells elicited by meningitic Escherichia coli	60
Correction: The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities	60
Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease	59
Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells	59
E3 ubiquitin ligase RNF128 negatively regulates the IL-3/STAT5 signaling pathway by facilitating K27-linked polyubiquitination of IL-3Rα	58