OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Translational Medicine is 71. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
A critical evaluation of berberine in NAFLD management: recommendations for improved research methodology	279
The PDE4 inhibitor tanimilast shows distinct immunomodulatory properties associated with a type 2 endotype and CD141 upregulation	243
Link of TMPRSS2 expression with tumor immunogenicity and response to immune checkpoint inhibitors in cancers	233
Two-sample Mendelian Randomization to evaluate the causal relationship between inflammatory arthritis and female-specific cancers	223
Correction to: Augmentation of tumor expression of HLADR, CXCL9, and CXCL10 may improve olfactory neuroblastoma immunotherapeutic responses	198
Analysis of thyroid carcinoma composition and spatial architecture in the progression of dedifferentiation, lymphatic metastasis, and gastric metastasis	196
Microplastics as an emerging driver of osteoarthritis: a translational synthesis of environmental exposure, patho-mechanisms, and public health implications	187
A novel deep learning-based algorithm combining histopathological features with tissue areas to predict colorectal cancer survival from whole-slide images	186
Computational pathology approach for assessment of prognosis and immunotherapy response in pan-gastrointestinal cancer	149
Alterations in whole muscle quality and physiological cross-sectional area measured with quantitative MRI following ACL injury	145
A call to reignite the revolutionary spirit of scientific discovery	144
Single-cell RNA sequencing reveals a B cell-related immunosuppressive landscape and a potential suppressor in hepatocellular carcinoma	144
KAT2B regulates estradiol synthesis via H3K27ac/PPARα in granulosa cells of PCOS patients	142
Pathway-based cancer transcriptome deciphers a high-resolution intrinsic heterogeneity within bladder cancer classification	139
From sensitivity to public health: integrating cfMeDIP-seq into early breast cancer detection strategies	135
Fully volumetric body composition analysis for prognostic overall survival stratification in melanoma patients	130
Spastin accumulation and motor neuron defects caused by a novel SPAST splice site mutation	130
Clinical impact of volume of disease and time of metastatic disease presentation on patients receiving enzalutamide or abiraterone acetate plus prednisone as first-line therapy for metastatic castrati	130
Inhibition of DDR1 potentiates carbon ion radiotherapy by promoting ferroptosis and immunogenic death in head and neck squamous cell carcinoma	128
Gender differences in eating habits and sports preferences across age groups: a cross-sectional study	125
Arginine-linked HPV-associated E7 displaying bacteria-derived outer membrane vesicles as a potent antigen-specific cancer vaccine	121
Prognosis-Related Nutritional Score for Cancer Patients (PRNS): a clinical nutritional score derived from a retrospective cohort study	121
Identification of epigenetic silencing of the SFRP2 gene in colorectal cancer as a clinical biomarker and molecular significance	120
Deciphering USP8’s pivotal role in cancer: mechanisms, clinical insights and contrasts with its function in pituitary adenomas	118
Identification of comutation in signaling pathways to predict the clinical outcomes of immunotherapy	116

The innovative checkpoint inhibitors of lung adenocarcinoma, cg09897064 methylation and ZBP1 expression reduction, have implications for macrophage polarization and tumor growth in lung cancer	114
Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer	112
Comprehensive analysis of microglia gene and subpathway signatures for glioma prognosis and drug screening: linking microglia to glioma	110
Correction: Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation	108
Vorinostat impairs the cancer-driving potential of leukemia-secreted extracellular vesicles	107
Associations of types of grains and lifestyle with all-cause mortality among Chinese adults aged 65 years or older: a prospective cohort study	104
Lactate infusion elevates cardiac output through increased heart rate and decreased vascular resistance: a randomised, blinded, crossover trial in a healthy porcine model	104
Dietary patterns, polygenic risk, and kidney cancer incidence: a UK Biobank cohort study	103
Ketoglutaric acid can reprogram the immunophenotype of triple-negative breast cancer after radiotherapy and improve the therapeutic effect of anti-PD-L1	102
Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancer	102
A novel model for predicting prolonged stay of patients with type-2 diabetes mellitus: a 13-year (2010–2022) multicenter retrospective case–control study	101
Peroxynitrite regulates ER stress-mediated Ca2+ flux to mitochondria characterizing cardiac microvascular ischemia–reperfusion injury associated with hyperhomocysteinemia	101
Immunogenicity of adalimumab in patients with noninfectious uveitis based on therapeutic drug monitoring	100
The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression	99
Identification of memory B-cell-associated miRNA signature to establish a prognostic model in gastric adenocarcinoma	98
Validity between dual-energy x-ray absorptiometry and bioelectrical impedance for segmental fat analysis and a novel low-cost model developed using anthropometry in young adults	97
Metabolomics approach reveals key plasma biomarkers in multiple myeloma for diagnosis, staging, and prognosis	96
Dissecting transcription of the 8q24-MYC locus in prostate cancer recognizes the equilibration between androgen receptor direct and indirect dual-functions	95
Gut microbiota analysis and LC-MS-based metabolomics to investigate AMPK/NF-κB regulated by Clostridium butyricum in the treatment of acute pancreatitis	95
Myomedin variants developed for in vitro PD-L1 diagnostics in tissue samples of non-small cell lung carcinoma patients	94
Red blood cell-derived arginase release in hemolytic uremic syndrome	94
Unleashing endogenous regeneration by senolytics	93
Incidence and immunomic features of apyretic COVID-19 in patients affected by solid tumors: a prospective cohort study	92
MicroRNA-24-3p targeting Top1 in perirenal fat is involved in circulating inflammation and high cardiovascular disease risk in patients with primary aldosteronism	91
Macrophages as determinants and regulators of systemic sclerosis-related interstitial lung disease	89
Immune-related lncRNAs signature and radiomics signature predict the prognosis and immune microenvironment of glioblastoma multiforme	89
CircNDC80 promotes glioblastoma multiforme tumorigenesis via the miR-139-5p/ECE1 pathway	87
Heat shock protein A4 ablation leads to skeletal muscle myopathy associated with dysregulated autophagy and induced apoptosis	85
Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma	82
SORBS2 as a molecular target for atherosclerosis in patients with familial hypercholesterolemia	82
Identification of novel first-trimester serum biomarkers for early prediction of preeclampsia	81
Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian popul	80
Artemisinin conferred cytoprotection to human retinal pigment epithelial cells exposed to amiodarone-induced oxidative insult by activating the CaMKK2/AMPK/Nrf2 pathway	80
The Swedish childhood tumor biobank: systematic collection and molecular characterization of all pediatric CNS and other solid tumors in Sweden	80
Hyperuricemia suppresses lumican, exacerbating adverse remodeling after myocardial infarction by promoting fibroblast phenotype transition	78
High VSX1 expression promotes the aggressiveness of clear cell renal cell carcinoma by transcriptionally regulating FKBP10	78
Effect of perioperative probiotic intervention on postoperative cognitive dysfunction in elderly patients: a randomized double- blinded and placebo-controlled trial	76
Radiogenomic MRI biomarkers for noninvasive prediction of GPC3 expression and tumor microenvironment in hepatocellular carcinoma	76
A bispecific antibody AP203 targeting PD-L1 and CD137 exerts potent antitumor activity without toxicity	75
The biological function of the N6-Methyladenosine reader YTHDC2 and its role in diseases	75
Polygenic risk score of metabolic dysfunction-associated steatotic liver disease amplifies the health impact on severe liver disease and metabolism-related outcomes	74
VLCKD: a real time safety study in obesity	73
Elevated NGF provokes decidual lipid peroxidation and promotes preterm birth in mice	73
Weighted gene coexpression network analysis and machine learning reveal oncogenome associated microbiome plays an important role in tumor immunity and prognosis in pan-cancer	73
SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner	72
Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations	71
Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis	71
NCAPG promotes the proliferation of hepatocellular carcinoma through the CKII-dependent regulation of PTEN	71
Precision information extraction for rare disease epidemiology at scale	71
Correction: NUCB2/Nesfatin-1 drives breast cancer metastasis through the up-regulation of cholesterol synthesis via the mTORC1 pathway	71