OOIR: Observatory of International Research

Papers

(The TQCC of Environmental Toxicology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
PM2.5‐induced pulmonary inflammation via activating of the NLRP3/caspase‐1 signaling pathway	81
The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase‐1 signaling pathway and oxidative stress in Wistar rats	70
Hesperidin protects against the chlorpyrifos‐induced chronic hepato‐renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up‐regulation of PARP‐1/V	51
Investigation of the effects of hesperidin administration on abamectin‐induced testicular toxicity in rats through oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, autophagy, a	46
Polystyrene nanoplastics potentiate the development of hepatic fibrosis in high fat diet fed mice	43
Polystyrene nanoplastics exacerbated lipopolysaccharide‐induced necroptosis and inflammation via the ROS/MAPK pathway in mice spleen	43
Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis	41
Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with oxidative stress and apoptosis in the head of ze	40
CircKDM4C upregulates P53 by sponging hsa‐let‐7b‐5p to induce ferroptosis in acute myeloid leukemia	40
Cadmium induces ferroptosis and apoptosis by modulating miR‐34a‐5p/Sirt1axis in PC12 cells	38
Long noncoding RNA H19 acts as a miR‐340‐3p sponge to promote epithelial‐mesenchymal transition by regulating YWHAZ expression in paclitaxel‐resistant breast cancer ce	37
An assessment of serum‐dependent impacts on intracellular accumulation and genomic response of per‐ and polyfluoroalkyl substances in a placental trophoblast model	37
Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes	36
CircRNA circ_POLA2 promotes lung cancer cell stemness via regulating the miR‐326/GNB1 axis	35
Exosomal lncRNA HMMR‐AS1 mediates macrophage polarization through miR‐147a/ARID3A axis under hypoxia and affects the progression of hepatocellular carcinoma	34
Chrysin ameliorates aluminum phosphide‐induced oxidative stress and mitochondrial damages in rat cardiomyocytes and isolated mitochondria	34
Chronic lung inflammation and pulmonary fibrosis after multiple intranasal instillation of PM₂_.5 in mice	34
Itraconazole attenuates the stemness of nasopharyngeal carcinoma cells via triggering ferroptosis	33
Ehrlich ascites carcinoma as model for studying the cardiac protective effects of curcumin nanoparticles against cardiac damage in female mice	33
Review on the ecotoxicological impacts of plastic pollution on the freshwater invertebrate Daphnia	33
Curcumin functions as an anti‐inflammatory and antioxidant agent on arsenic‐induced hepatic and kidney injury by inhibiting MAPKs/NF‐κB and activating Nrf2	33
Enhanced anticancer potency of hydroxytyrosol and curcumin by PLGA‐PAA nano‐encapsulation on PANC‐1 pancreatic cancer cell line	33
ROS‐mediated PERK‐eIF2α‐ATF4 pathway plays an important role in arsenite‐induced L‐02 cells apoptosis via regulating CHOP‐DR5 signaling	33
Developmental toxicity induced by Cu(OH)₂ nanopesticide in zebrafish embryos	32
Deltamethrin induces apoptosis in cerebrum neurons of quail via promoting endoplasmic reticulum stress and mitochondrial dysfunction	31

Melatonin increases the anticancer potential of doxorubicin in Caco‐2 colorectal cancer cells	30
Di‐(2‐ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice	29
PM2.5 induces endothelial dysfunction via activating NLRP3 inflammasome	29
A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2‐positive breast cancer through regulating ferroptosis	29
An ecofriendly synthesized gold nanoparticles induces cytotoxicity via apoptosis inHepG2cells	28
Evaluation of protective effects of quercetin against cypermethrin‐induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway	27
Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway	27
Silica dust exposure induces pulmonary fibrosis through autophagy signaling	27
LncRNA MEG3 mediates nickel oxide nanoparticles‐induced pulmonary fibrosis via suppressing TGF‐β1 expression and epithelial‐mesenchymal transition process	26
The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells	26
Imbalanced inflammatory response in subchronic arsenic‐induced liver injury and the protective effects of Ginkgo biloba extract in rats: Potential role of cytokines mediated cell–cel	26
Lagerstroemia speciosa (L.) Pers. triggers oxidative stress mediated apoptosis via intrinsic mitochondrial pathway in HepG2 cells	26
Overexpression of HIF‐1α enhances the protective effect of mitophagy on steroid‐induced osteocytes apoptosis	26
Lithium intoxication induced pyroptosis via ROS/NF‐κB/NLRP3 inflammasome regulatory networks in kidney of mice	26
Nootkatone improves anxiety‐ and depression‐like behavior by targeting hyperammonemia‐induced oxidative stress in D‐galactosamine model of liver injury	25
Verbascoside inhibits the epithelial‐mesenchymal transition of prostate cancer cells through high‐mobility group box 1/receptor for advanced glycation end‐products/TGF‐β pathway	24
Resveratrol improved hippocampal neurogenesis following lead exposure in rats through activation of SIRT1 signaling	24
Serum cadmium positively correlates with inflammatory cytokines in patients with chronic obstructive pulmonary disease	24
Environmental relevant concentrations of triclosan affected developmental toxicity, oxidative stress, and apoptosis in zebrafish embryos	24
Cardioprotective potential of amygdalin against angiotensin II induced cardiac hypertrophy, oxidative stress and inflammatory responses through modulation of Nrf2 and NF‐κB activ	24
Responses of Cirrhinus mrigala to second‐generation fluoroquinolone (ciprofloxacin) toxicity: Assessment of antioxidants, tissue morphology, and inorganic ions	24
Bisphenol A induced apoptosis via oxidative stress generation involved Nrf2/HO‐1 pathway and mitochondrial dependent pathways in human retinal pigment epithelium (	23
Polystyrene microplastics induce apoptosis and necroptosis in swine testis cells via ROS/MAPK/HIF1α pathway	23
Curcumin suppresses the stemness of non‐small cell lung cancer cells via promoting the nuclear‐cytoplasm translocation of TAZ	22
Kaempferol inhibits the cell migration of human hepatocellular carcinoma cells by suppressing MMP‐9 and Akt signaling	22
Borneol protects against cerulein‐induced oxidative stress and inflammation in acute pancreatitis mice model	21
Polystyrene microplastic particles induce autophagic cell death in BEAS‐2B human bronchial epithelial cells	20
Demethoxycurcumin induces apoptosis in HER2 overexpressing bladder cancer cells through degradation of HER2 and inhibiting the PI3K/Akt pathway	20
Plumbagin protects the myocardial damage by modulating the cardiac biomarkers, antioxidants, and apoptosis signaling in the doxorubicin‐induced cardiotoxicity in rats	20
Inhibition of ALKBH5‐mediated m⁶A modification of PPARG mRNA alleviates H/R‐induced oxidative stress and apoptosis in placenta trophoblast	20
Diosmetin alleviates cerebral ischemia‐reperfusion injury through Keap1‐mediated Nrf2/ARE signaling pathway activation and NLRP3 inflammasome inhibition	20
Nigella sativa oil protects against emamectin benzoate‐Induced neurotoxicity in rats	20
Calycosin alleviates H₂O₂‐induced astrocyte injury by restricting oxidative stress through the Akt/Nrf2/HO‐1 signaling pathway	20
Benzo[a]pyrene exposure and overcrowding stress impacts anxiety‐like behavior and impairs learning and memory in adult zebrafish, Danio rerio	20
Cytotoxicity of naringenin induces Bax‐mediated mitochondrial apoptosis in human lung adenocarcinoma A549 cells	20
Melatonin ameliorates Bisphenol S induced testicular damages by modulating Nrf‐2/HO‐1 and SIRT‐1/FOXO‐1 expressions	19
Nickel oxide nanoparticles induce apoptosis and ferroptosis in airway epithelial cells via ATF3	19
MiR‐122‐5p and miR‐326‐3p promote cadmium‐induced NRK‐52E cell apoptosis by downregulating PLD1	19
High‐fat diet exacerbates lead‐induced blood–brain barrier disruption by disrupting tight junction integrity	18
Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK	18
Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib‐resistant melanoma cells by downregulating the EGFR signaling pathway	18
Brucine promotes apoptosis in cervical cancer cells (ME‐180) via suppression of inflammation and cell proliferation by regulating PI3K/AKT/mTOR signaling pa	18
Delphinidin modulates JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells	18
Mangiferin inhibits lipopolysaccharide‐induced epithelial‐mesenchymal transition (EMT) and enhances the expression of tumor suppressor gene PER1 in non‐small cell lung cancer cells	18
Hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish following sub‐chronic exposure to BDE‐47 and BDE‐153	17
Potential chemotherapeutic effect of betalain against human non‐small cell lung cancer through PI3K/Akt/mTOR signaling pathway	17
MiR‐186‐5p suppresses cell migration, invasion, and epithelial mesenchymal transition in bladder cancer by targeting RAB27A/B	17
Hsa_circ_0001073 targets miR‐626/LIFR axis to inhibit lung cancer progression	17
Long noncodingRNA MCF2L‐AS1promotes the cancer stem cell‐like traits in non‐small cell lung cancer cells through regulatingmiR‐873‐5p level	17
The dual role of boron in vitro neurotoxication of glioblastoma cells via SEMA3F/NRP2 and ferroptosis signaling pathways	17

Scutellarin alleviates cerebral ischemia/reperfusion by suppressing oxidative stress and inflammatory responses via MAPK/NF‐κB pathways in rats	17
Reproductive organ dysfunction and gene expression after orally administration of ZnO nanoparticles in murine	17
LncRNA SNHG14 contributes to proinflammatory cytokine production in rheumatoid arthritis via the regulation of the miR‐17‐5p/MINK1‐JNK pathway	17
Resveratrol reduces DRP1‐mediated mitochondrial dysfunction via the SIRT1‐PGC1α signaling pathway in manganese‐induced nerve damage in mice	17
Extracts of Jasminum sambac flowers fermented by Lactobacillus rhamnosus inhibit H₂O₂‐ and UVB‐induced aging in human dermal fibrob	17
Dual down‐regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells	17
Fucoxanthin treatment inhibits nasopharyngeal carcinoma cell proliferation through induction of autophagy mechanism	17
Perfluorooctane sulfonate‐induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol	17
Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells	16
Polystyrene microplastics induce autophagy and apoptosis in birds lungs via PTEN/PI3K/AKT/mTOR	16
Long noncoding RNA FAM66C promotes tumor progression and glycolysis in intrahepatic cholangiocarcinoma by regulating hsa‐miR‐23b‐3p/KCND2 axis	16
Comparative assessment of neurotoxicity impacts induced by alkyl tri‐n‐butyl phosphate and aromatic tricresyl phosphate in PC12 cells	16
Inorganic arsenic‐mediated upregulation of AS3MT promotes proliferation of nonsmall cell lung cancer cells by regulating cell cycle genes	16
Toxicity of thioacetamide and protective effects of quercetin in zebrafish (Danio rerio) larvae	16
Long noncoding RNA MACC1‐AS1 promotes the stemness of nonsmall cell lung cancer cells through promoting UPF1‐mediated destabilization of LATS1/2	16
The therapeutic effects of Prunella vulgaris against fluoride‐induced oxidative damage by using the metabolomics method	16
Effect of inorganic mercury exposure on reproductive system of male mice: Immunosuppression and fibrosis in testis	16
LncRNA PVT1 contributes to invasion and doxorubicin resistance of bladder cancer cells through promoting MDM2 expression and AURKB‐mediated p53 ubiquitination	16
Silica nanoparticles induce mitochondrial pathway‐dependent apoptosis by activating unfolded protein response in human neuroblastoma cells	16
DNA damage, immunotoxicity, and neurotoxicity induced by deltamethrin on the freshwater crayfish, Procambarus clarkii	16
Silencing of miR‐497‐5p inhibits cell apoptosis and promotes autophagy in Parkinson's disease by upregulation of FGF2	16
Reactive oxygen species regulate miR‐17‐5p expression via DNA methylation in paraquat‐induced nerve cell damage	16
Autophagic response of intestinal epithelial cells exposed to polystyrene nanoplastics	15
Effects of 2,4‐dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy‐related proteins as well as the protective effect of Lycium barbarum polysaccharide in	15
Syringin alleviates ovalbumin‐induced lung inflammation in BALB/c mice asthma model via NF‐κB signaling pathway	15
Combined lead and zinc oxide‐nanoparticles induced thyroid toxicity through 8‐OHdG oxidative stress‐mediated inflammation, apoptosis, and Nrf2 activation in rats	15
Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism	15
Luteolin‐7‐O‐glucoside inhibits cell proliferation and modulates apoptosis through the AKT signaling pathway in human nasopharyngeal carcinoma	15
Suppression of bisphenol A‐induced oxidative stress by taurine promotes neuroprotection and restores altered neurobehavioral response in zebrafish (Danio rerio)	15
Anti‐ulcerative effects of wogonin on ulcerative colitis induced by dextran sulfate sodium via Nrf2/TLR4/NF‐κB signaling pathway in BALB/c mice	15
Protection of melatonin against long‐term radon exposure‐caused lung injury	15
Single and combined effects of carbamazepine and copper on nervous and antioxidant systems of zebrafish (Danio rerio)	14
ROCK inhibitor attenuates carbon blacks‐induced pulmonary fibrosis in mice via Rho/ROCK/NF‐kappa B pathway	14
Ochratoxin A induces human kidney tubular epithelial cell apoptosis through regulating lipid raft/PTEN/AKT signaling pathway	14
Selenium protects against cadmium‐induced cardiac injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling	14
MEOX1 suppresses the progression of lung cancer cells by inhibiting the cell‐cycle checkpoint gene CCNB1	14
Traditional Chinese medicine formula T33 inhibits the proliferation of human colorectal cancer cells by inducing autophagy	14
Pitavastatin and metformin synergistically activate apoptosis and autophagy in pancreatic cancer cells	14
circ_0089153 exacerbates breast cancer cells proliferation and metastasis via sponging miR‐2467‐3p/E2F6	14
Protective effect of nimbolide against streptozotocin induced gestational diabetes mellitus in rats via alteration of inflammatory reaction, oxidative stress, and gut microbiota	14
Poly(ADP‐ribose) glycohydrolase silencing‐mediated H2B expression inhibits benzo(a)pyrene‐induced carcinogenesis	14
Toxicogenicity and mechanistic pathways of aflatoxinB1induced renal injury	14
Arecoline induces heart injure via Fas/Fas ligand apoptotic pathway in heart of Sprague–Dawley rat	14
DLX6‐AS1 accelerates cell proliferation through regulating miR‐497‐5p/SNCG pathway in prostate cancer	13
Triclosan regulates the Nrf2/HO‐1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons	13
Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF‐κB‐mediated anti‐apoptotic potential in glioblastoma	13
Hsp70 overexpression in Drosophila hemocytes attenuates benzene‐induced immune and developmental toxicity via regulating ROS/JNK signaling pathway	13
Luteolin mitigates potassium dichromate‐induced nephrotoxicity, cardiotoxicity and genotoxicity through modulation of Kim‐1/Nrf2 signaling pathways	13
LINC01234 aggravates cell growth and migration of triple‐negative breast cancer by activating the Wnt pathway	13
Dieckol alleviates dextran sulfate sodium‐induced colitis via inhibition of inflammatory pathway and activation of Nrf2/HO‐1 signaling pathway	13
Thiamethoxam‐induced oxidative stress, lipid peroxidation, and disturbance of steroidogenic genes in male rats: Palliative role of Saussurea lappa and Silybum marianum	13
Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor‐positive breast cancer therapy: An in vitro study	13
Carvacrol reduces abnormal and dead sperm counts by attenuating sodium arsenite‐induced oxidative stress, inflammation, apoptosis, and autophagy in the testicular tissues of rats	13
Glycine protects the male reproductive system against lead toxicity via alleviating oxidative stress, preventing sperm mitochondrial impairment, improving kinematics of sperm, and blunting the downreg	13
Protective effect of hesperidin against N,N′‐dimethylhydrazine induced oxidative stress, inflammation, and apoptotic response in the colon of Wistar rats	13
HBCD, TBECH, and BTBPE exhibit cytotoxic effects in human vascular endothelial cells by regulating mitochondria function and ROS production	13
Effects of lead exposure on the activation of microglia in mice fed with high‐fat diets	13
Integrated analysis of multi‐omics data on epigenetic changes caused by combined exposure to environmental hazards	13
Carvacrol protects against λ‐Cyhalothrin‐induced hepatotoxicity and nephrotoxicity by modulating oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy	12
Sorafenib reduces steatosis‐induced fibrogenesis in a human 3D co‐culture model of non‐alcoholic fatty liver disease	12
LINC00473 downregulation facilitates trophoblast cell migration and invasion via the miR‐15a‐5p/LITAF axis in pre‐eclampsia	12
2,4‐dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body‐induced autophagy disorder in microglia and the protective effect of Lycium barbarum polys	12
PM₂_.5 exposure‐induced ferroptosis in neuronal cells via inhibiting ERK/CREB pathway	12
Antimycin A shows selective antiproliferation to oral cancer cells by oxidative stress‐mediated apoptosis and DNA damage	12
Sub‐chronic exposure to ammonia inhibits the growth of juvenile Wuchang bream (Megalobrama amblycephala) mainly by downregulation of growth hormone/insulin‐like growth factor axis	12
Glyburide attenuates B(a)p and LPS‐induced inflammation‐related lung tumorigenesis in mice	12
Corynoline protects lipopolysaccharide‐induced mastitis through regulating AKT/GSK3β/Nrf2 signaling pathway	12
Circ‐SNAP47 (hsa_circ_0016760) and miR‐625‐5p are regulators of WEE1 in regulation of chemoresistance, growth and invasion of DDP‐tolerant NSCLC cells via ceRNA pathway	12
Ginsenoside Rg1 ameliorates reproductive function injury in C57BL/6J mice induced by di‐N‐butyl‐phthalate	12
Protective effects of ethyl acetate extract from Shorea roxburghii against diabetes induced testicular damage in rats	12
The antagonistic effect of melatonin on TBBPA‐induced apoptosis and necroptosis via PTEN/PI3K/AKT signaling pathway in swine testis cells	12
Long non‐coding RNA DUXAP9 promotes hepatocellular carcinoma cell stemness via directly interacting with sox9	12
Long non‐coding RNA NORAD aggravates acute myocardial infarction by promoting fibrosis and apoptosis via miR‐577/COBLL1 axis	12
CircRNA circSTIL inhibits ferroptosis in colorectal cancer via miR‐431/SLC7A11 axis	12
Chitosan attenuated the neurotoxicity‐induced titanium dioxide nanoparticles in brain of adult rats	12
Seven traditional Chinese herbal extracts fermented by Lactobacillus rhamnosus provide anti‐pigmentation effects by regulating the CREB/MITF/tyrosina	12
ROS generation is involved in titanium dioxide nanoparticle‐induced AP‐1 activation through p38 MAPK and ERK pathways in JB6 cells	12
RNA‐binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3′UTR with miR‐92a‐3p	12
Nano nickel oxide promotes epithelial‐mesenchymal transition through transforming growth factor β1/smads signaling pathway in A549 cells	12
LncRNA MEG3 restrained pulmonary fibrosis induced by NiO NPs via regulating hedgehog signaling pathway‐mediated autophagy	12

Low concentration triphenyl phosphate fuels proliferation and migration of hepatocellular carcinoma cells	12
LncRNA PSMA3‐AS1 promotes cell proliferation, migration, and invasion in ovarian cancer by activating the PI3K/Akt pathway via the miR‐378a‐3p/GALNT3 axis	12
Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability	12
SH3PXD2A‐AS1/miR‐330‐5p/UBA2 ceRNA network mediates the progression of colorectal cancer through regulating the activity of the Wnt/β‐catenin signaling pathway	11
Per‐ and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells	11
Sinapic acid mitigates methotrexate‐induced hepatic injuries in rats through modulation of Nrf‐2/HO‐1 signaling	11
Estrogen receptor‐α36 is involved in diallyl sulfide‐induced inhibition of malignant growth of HepG2 and Huh7 hepatocellular carcinoma cells	11
LncRNA RHPN1‐AS1 inhibition induces autophagy and apoptosis in prostate cancer cells via the miR‐7‐5p/EGFR/PI3K/AKT/mTOR signaling pat	11
PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis	11
TRIP13 exerts a cancer‐promoting role in cervical cancer by enhancing Wnt/β‐catenin signaling via ACTN4	11
Bergenin alleviates H₂O₂‐induced oxidative stress and apoptosis in nucleus pulposus cells: Involvement of the PPAR‐γ/NF‐κB pathway	11
In vitro antimetastatic activity of Momordica balsamina crude acetone extract in HT‐29 human colon cancer cells	11
CircSmg5 stimulates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting the miR‐194‐5p/Fzd6 axis and beta‐catenin signaling	11
Long noncoding RNA LINC01287 promotes proliferation and inhibits apoptosis of lung adenocarcinoma cells via the miR‐3529‐5p/RNASEH2A axis under the competitive endogen	11
Puerarin alleviates cadmium‐induced oxidative damage to bone by reducing autophagy in rats	11
Molecular and biochemical investigation of the protective effects of rutin against liver and kidney toxicity caused by malathion administration in a rat model	11
CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR‐375/SLC7A11 axis	11
Adolescent cadmium exposure impairs cognition and hippocampal neurogenesis in C57BL/6 mice	11
Prognostic impact of lactylation‐associated gene modifications in clear cell renal cell carcinoma: Insights into molecular landscape and therapeutic opportunities	11
LncRNA NCK1‐AS1 exerts oncogenic property in gastric cancer by targeting the miR‐22‐3p/BCL9 axis to activate the Wnt/β‐catenin signaling	11
miR‐146a promotes proliferation, invasion, and epithelial‐to‐mesenchymal transition in oral squamous carcinoma cells	11
Low concentrations of 17β‐estradiol exacerbate tamoxifen resistance in breast cancer treatment through membrane estrogen receptor‐mediated signaling pathways	11
Butein induces cellular senescence through reactive oxygen species‐mediated p53 activation in osteosarcoma U‐2 OS cells	11
Poria cocos (Fuling) targets TGFβ/Smad7 associated collagen accumulation and enhances Nrf2‐antioxidant mechanism to exert anti‐skin aging effects in human dermal fibroblasts	11
Insight into the mechanism of aspartame‐induced toxicity in male reproductive system following long‐term consumption in mice model	10
The role of H3K9me2‐regulated base excision repair genes in the repair of DNA damage induced by arsenic in HaCaT cells and the effects of Ginkgo biloba	10
β‐Amyrin ameliorates diabetic nephropathy in mice and regulates the miR‐181b‐5p/HMGB2 axis in high glucose‐stimulated HK‐2 cells	10
Ursolic acid reduces Adriamycin resistance of human ovarian cancer cells through promoting the HuR translocation from cytoplasm to nucleus	10
Prostate cancer‐secreted CCN3 uses the GSK3β and β‐catenin pathways to enhance osteogenic factor levels in osteoblasts	10
Inhibition of NCAPG expression inactivates the Wnt/β‐catenin signal to suppresses endometrial cancer cell growth in vitro	10
LncRNA LINC00115 facilitates lung cancer progression through miR‐607/ITGB1 pathway	10
Miconazole induces protective autophagy in bladder cancer cells	10
ABCA8 inhibits breast cancer cell proliferation by regulating the AMP activated protein kinase/mammalian target of rapamycin signaling pathway	10
Histopathological evaluation of the interrenal gland (adrenal homolog) of Japanese medaka (Oryzias latipes) exposed to graphene oxide	10
A macrolide from Streptomyces sp. modulates apoptosis and autophagy through Mcl‐1 downregulation in human breast cancer cells	10
hUC‐MSCs exosomal miR‐451 alleviated acute lung injury by modulating macrophage M2 polarization via regulating MIF‐PI3K‐AKT signaling pathway	10
The crosstalk between mitochondrial dysfunction and endoplasmic reticulum stress promoted ATF4‐mediated mitophagy induced by hexavalent chromium	10
Inhibition of the notch signaling pathway overcomes resistance of cervical cancer cells to paclitaxel through retardation of the epithelial–mesenchymal transition process	10
Glyphosate‐based herbicides induces autophagy in IPEC‐J2 cells and the intervention of N‐acetylcysteine	10
circ_0008797 attenuates non‐small cell lung cancer proliferation, metastasis, and aerobic glycolysis by sponging miR‐301a‐3p/SOCS2	10
Effects of naringin on oxidative stress, inflammation, some reproductive parameters, and apoptosis in acrylamide‐induced testis toxicity in rat	10
Protective effect of C‐phycocyanin and apo‐phycocyanin subunit on programmed necrosis of GC‐1 spg cells induced by H₂O₂	10
Effect of resveratrol on the inflammatory status and oxidative stress in thymus gland and spleen of sulfoxaflor‐treated rats	10
Arecoline induces epithelial mesenchymal transition in HK2 cells by upregulating the ERK‐mediated signaling pathway	10
N‐acetylcysteine reduced the immunotoxicity effects induced in vitro by azoxystrobin and iprodione fungicides in mice	10
Propolis nanoparticles modulate the inflammatory and apoptotic pathways in carbon tetrachloride‐induced liver fibrosis and nephropathy in rats	10
Uranium induces kidney cells apoptosis via reactive oxygen species generation, endoplasmic reticulum stress and inhibition of PI3K/AKT/mTOR signaling in culture	10
CRABP2 accelerates epithelial mesenchymal transition in serous ovarian cancer cells by promoting TRIM16 methylation via upregulating EZH2 expression	10
Cadmium modulates steatosis, fibrosis, and oncogenic signaling in liver cancer cells by activating notch and AKT/mTOR pathways	10
circZFR regulates thyroid cancer progression by the miR‐16/MAPK1 axis	10
DNA damage and cell apoptosis induced by fungicide difenoconazole in mouse mononuclear macrophage RAW264.7	10
Mechanisms of acrolein induces toxicity in human umbilical vein endothelial cells: Oxidative stress, DNA damage response, and apoptosis	10
Dihydromyricetin inhibits cancer cell migration and matrix metalloproteinases‐2 expression in human nasopharyngeal carcinoma through extracellular signal‐regulated kinase signaling pathway	10
Melatonin improves bisphenol A‐induced cell apoptosis, oxidative stress and autophagy impairment via inhibition of the p38 MAPK signaling pathway in FLK‐BLV cells	10
Thymoquinone loaded calcium alginate and polyvinyl alcohol carrier inhibits the 7,12‐dimethylbenz[a]anthracene‐induced hamster oral cancer via the down‐regulation of PI3K/AKT/	10
Linseed ameliorates renal apoptosis in rat fetuses induced by single or combined exposure to diesel nanoparticles or fenitrothion by inhibiting transcriptional activation of p21/p53 and caspase‐3/9 th	10
Shh‐Yap signaling controls hepatic ductular reactions in CCl₄‐induced liver injury	10
Shikonin ameliorates injury and inflammatory response of LPS‐stimulated WI‐38 cells via modulating the miR‐489‐3p/MAP2K1 axis	10
Nano‐selenium attenuates mitochondrial‐associated apoptosis via the PI3K/AKT pathway in nickel‐induced hepatotoxicity in vivo and in vitro	9
Compound essential oils relieve oxidative stress caused by PM₂_.5 exposure by inhibiting autophagy through the AMPK/mTOR pathway	9
Syringic acid and silymarin concurrent administration inhibits sodium valproate‐induced liver injury in rats	9
SIRT1/mTOR pathway‐mediated autophagy dysregulation promotes Pb‐induced hepatic lipid accumulation in HepG2 cells	9
Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation	9
Biochemical study on the protective effect of curcumin on acetaminophen and gamma‐irradiation induced hepatic toxicity in rats	9
Dichloroacetate attenuates the stemness of hepatocellular carcinoma cells via promoting nucleus‐cytoplasm translocation of YAP	9
GPX4 utilization by selenium is required to alleviate cadmium‐induced ferroptosis and pyroptosis in sheep kidney	9
Ginsenoside Rg1 suppresses paraquat‐induced epithelial cell senescence by enhancing autophagy in an ATG12‐dependent manner	9
Trimetazidine improved adriamycin‐induced cardiomyopathy by downregulating TNF‐α, BAX, and VEGF immunoexpression via an antioxidant mechanism	9
T‐2 toxin‐induced femur lesion is accompanied by autophagy and apoptosis associated with Wnt/β‐catenin signaling in mice	9
Dioscorea nipponica Makino suppresses TPA‐induced migration and invasion through inhibition of matrix metalloproteinase‐9 in human cervical cancer cells	9
Gallic acid: A promising genoprotective and hepatoprotective bioactive compound against cyclophosphamide induced toxicity in mice	9
Exposure to neonicotinoids and serum testosterone in men, women, and children	9
Fucoxanthin decreases lipopolysaccharide‐induced acute lung injury through the inhibition of RhoA activation and the NF‐κB pathway	9
miR‐486‐3p regulates CyclinD1 and promotes fluoride‐induced osteoblast proliferation and activation	9
Procyanidin protects human retinal pigment epithelial cells from high glucose by inhibiting autophagy	9
In vivo hepatoprotective effect of Morinda elliptica stem extract against liver fibrosis induced by thioacetamide	9
Acute iron oxide nanoparticles exposure induced murine eosinophilic airway inflammation via TLR2 and TLR4 signaling	9
Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells	9
Microcrystalline silica particles induce inflammatory response via pyroptosis in primary human respiratory epithelial cells	9
Long noncoding RNA OIP5‐AS1 promotes the stemness of lung cancer cells through enhancing Oct4 mRNA stability	9
Adverse effects of chronic ammonia stress on juvenile oriental river prawn (Macrobrachium nipponense) and alteration of glucose and ammonia metabolism	9
MiR‐1246 is responsible for lung cancer cells‐derived exosomes‐mediated promoting effects on lung cancer stemness via targeting TRIM17	9
Downregulation of estrogen receptor‐α36 expression attenuates metastasis of hepatocellular carcinoma cells	9
Long non‐coding RNA LINC00514 promotes the proliferation and invasion through the miR‐708‐5p/HOXB3 axis in cervical squamous cell carcinoma	9
A novel mechanism of cannabidiol in suppressing ovarian cancer through LAIR‐1 mediated mitochondrial dysfunction and apoptosis	9
Caffeic acid phenethyl ester induces radiosensitization via inhibition of DNA damage repair in androgen‐independent prostate cancer cells	9
Fat1 suppresses the tumor‐initiating ability of nonsmall cell lung cancer cells by promoting Yes‐associated protein 1 nuclear‐cytoplasmic translocation	9
Antagonistic effect of selenium on mercuric chloride in the central immune organs of chickens: The role of microRNA‐183/135b‐FOXO1/TXNIP/NLRP3 inflammasome	9
Pipoxolan suppresses the inflammatory factors of NF‐κB, AP‐1, and STATs, but activates the antioxidative factor Nrf2 in LPS‐stimulated RAW 264.7	9
Activation of Nrf2/HO‐1 signaling pathway attenuates ROS‐mediated autophagy induced by silica nanoparticles in H9c2 cells	9
Galectin‐3 facilitates inflammation and apoptosis in chondrocytes through upregulation of the TLR‐4‐mediated oxidative stress pathway in TC28a2 human chondrocyte cells	9
Long noncoding RNA ST8SIA6‐AS1 promotes cell proliferation and metastasis in triple‐negative breast cancer by targeting miR‐145‐5p/CDCA3 to inactivate the p53/p21 sign	9
Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma	9
CircFAM64A enhances cellular processes in triple‐negative breast cancer by targeting the miR‐149‐5p/CDT1 axis	9
Resveratrol inhibits oral squamous cell carcinoma cells proliferation while promoting apoptosis through inhibition of CBX7 protein	9