IUBMB Life

Article	Citations
Issue Information	79
Issue Information	64
Protein Tyrosine Phosphatases: Mighty oaks from little acorns grow	47
The roles of proteases in prostate cancer	44
Integrated multi‐omics and machine learning reveal a gefitinib resistance signature for prognosis and treatment response in lung adenocarcinoma	43
SNHG14 promotes triple‐negative breast cancer cell proliferation, invasion, and chemoresistance by regulating the ERK/MAPK signaling pathway	41
The role of the proteasome in mitochondrial protein quality control	41
Issue Information	40
Serum/glucocorticoid‐regulated kinase 1‐targeted transient receptor potential oxalate subtype 1 regulates bladder smooth muscle cell proliferation due to bladder outlet obstruction in mice via activat	37
Thiourea derivatives inhibit key diabetes‐associated enzymes and advanced glycation end‐product formation as a treatment for diabetes mellitus	36
Irisin alleviates the pyroptosis of β cells in T2DM by inhibiting NLRP3 inflammasome through regulating miR‐19b‐3p/SOCS3/STAT3 axis mediated auto	36
Anti‐inflammatory effects of sodium‐glucose cotransporter‐2 inhibitors in COVID‐19	32
Mitochondrial protein and organelle quality control—Lessons from budding yeast	30
SHP2: The protein tyrosine phosphatase involved in chronic pulmonary inflammation and fibrosis	29
Discovery and Validation of a New Biomarker Integrating Ferroptosis and Glycolysis‐Related Genes in Bladder Cancer	28
Central nervous system cholesterol metabolism in health and disease	28
Gastrointestinal tissue as a “new” target of pollution exposure	27
Modulation of PPAR‐α and PPAR‐γ Influences Cardiomyocyte Growth and Cardiac Remodeling	27
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Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer	23
Combined doxorubicin and arctigenin treatment induce cell cycle arrest‐associated cell death by promoting doxorubicin uptake in doxorubicin‐resistant breast cancer cells	23
Underlying selection for the diversity of spike protein sequences of SARS‐CoV‐2	23
Potential COVID‐19 remedies from repurposed drugs and herbal small RNAs	21
Cholesterol‐dependent cytolysins: The outstanding questions	21

RETRACTION: Nutritional Flavonoids Modulate Estrogen Receptor α Signaling	21
Neuroprotective effects of resveratrol through modulation of PI3K/Akt/GSK‐3β pathway and metalloproteases	20
Optimization of the chromium (Cr+6) reduction from waterways using chemically and bacterially treated agro‐waste	20
MST4 as a novel therapeutic target for autophagy and radiosensitivity in gastric cancer	20
Kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP‐1 expression, and the STAT3 pathway	19
miR‐203a—A multifaceted regulator modulating cancer hallmarks and therapy response	19
Low expression of PCK2 in breast tumors contributes to better prognosis by inducing senescence of cancer cells	19
miR‐126 regulates the proliferation, migration, invasion, and apoptosis of non‐small lung cancer cells via AKT2/HK2 axis	18
Non‐coding RNA regulatory networks in post‐transcriptional regulation of VEGFA in cancer	18
Circular RNAs in chemotherapy resistance of lung cancer and their potential therapeutic application	17
N6‐methyladenosine regulators are potential prognostic biomarkers for multiple myeloma	17
Nicotinamide mononucleotide alters body composition and ameliorates metabolic disorders induced by a high‐fat diet	17
Issue Highlights	16
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FOXO transcription factors in antioxidant defense	16
CD38/cADPR‐mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1	15
2‐Deoxy‐d‐glucose exploits increased glucose metabolism in cancer and viral‐infected cells: Relevance to its use in India against SARS‐CoV‐2	15
Overexpression of RGPR‐p117 reveals anticancer effects by regulating multiple signaling pathways in bone metastatic human breast cancer MDA‐MB‐231 cells	15
Eddy Fischer—Renaissance scientist and bon viveur	15
Issue Information	15
Dynamic association of flavin cofactors to regulate flavoprotein function	14
One‐year mortality and consequences of COVID‐19 in cancer patients: A cohort study	14
Enhanced HER2 status detection in breast and gastric cancers using surrogate DNA methylation markers	13
Mechanisms of epigenetic regulation of transcription by lncRNAs in plants	13
Knockdown of ST6Gal‐I expression in human hepatocellular carcinoma cells inhibits their exosome‐mediated proliferation‐ and migration‐promoting effects	13
2‐Deoxy‐D‐glucose simultaneously targets glycolysis and Wnt/β‐catenin signaling to inhibit cervical cancer progression	13
Central nervous system organoids for modeling neurodegenerative diseases	13
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Adaptation of cardiomyogenesis to the generation and maturation of cardiomyocytes from human pluripotent stem cells	12
Issue Highlights	12
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Adverse fetal and neonatal impact of war conflicts during pregnancy: A systematic review	12
Particulate matters 2.5 induce tumor progression in lung cancer by increasing the activity of hnRNPA2B1 resulting in retarding mRNA decay of oxidative phosphorylation	12
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Role of extracellular vesicles in mitochondrial eye diseases	11
Unraveling antiviral efficacy of multifunctional immunomodulatory triterpenoids against SARS‐COV‐2 targeting main protease and papain‐like protease	11
Experimental evolution of extremotolerant and extremophilic fungi under osmotic stress	11
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Lectins CGL and MTL, representatives of mytilectin family, exhibit different antiproliferative activity in Burkitt's lymphoma cells	11
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Euryhaline Black Yeasts From the Arabian Gulf: Descriptions of Salinomyces qatarensis sp. nov. and Hortaea werneckii Genotypic Variations	11
Mitochondrial respiratory supercomplexes of the yeast Saccharomyces cerevisiae	11
Issue Highlights	10
Endoplasmic reticulum stress and NF‐kB activation in SARS‐CoV‐2 infected cells and their response to antiviral therapy	10
Neuroprotection and mechanisms of ginsenosides in nervous system diseases: Progress and perspectives	10
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Erythroid spectrin binding modulates peroxidase and catalase activity of heme proteins	10
Imperative connotation of SODs in cancer: Emerging targets and multifactorial role of action	10
The up‐regulation of RIPK3 mediated by ac4C modification promotes oxidative stress‐induced granulosa cell senescence by inhibiting the Nrf2/HO‐1 pathway	10

Correction to “Upstream Transcription Factor 1 Suppresses Laryngeal Squamous Cell Carcinoma Progression Through Transcriptional Activation of Junctional Adhesion Molecule 3”	10
RNA processing and degradation mechanisms shaping the mitochondrial transcriptome of budding yeasts	9
Issue Information	9
Pseudoexfoliation syndrome: The critical role of the extracellular matrix in pathogenesis and treatment	9
Desaturases: Structural and mechanistic insights into the biosynthesis of unsaturated fatty acids	8
RetroGREAT signaling: The lessons we learn from yeast	8
Comparative analysis of the potential of the secretomes of cardiac resident stromal cells and fibroblasts	8
Early steps in the biogenesis of mitochondrially encoded oxidative phosphorylation subunits	8
Genomic features of lichen‐associated black fungi	8
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Greater TIMP‐1 protein levels and neointimal formation represent sex‐dependent cellular events limiting aortic vessel expansion in female rats	8
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Ferulic acid ameliorates acetaminophen‐induced acute liver injury by promoting AMPK‐mediated protective autophagy	8
Depletion of macrophages and osteoclast precursors mitigates iron overload‐mediated bone loss	8
EXPRESSION OF CONCERN: Laccase Treatment Impairs Bisphenol A‐Induced Cancer Cell Proliferation Affecting Estrogen Receptor α‐Dependent Rapid Signals	8
A standardised nomenclature for long non‐coding RNAs	8
Parecoxib inhibits tumorigenesis and angiogenesis in hepatocellular carcinoma through ERK–VEGF/MMPs signaling pathway	8
Corrigendum	8
CRYAB is upregulated and predicts clinical prognosis in kidney renal clear cell carcinoma	7
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Neuromelanins in brain aging and Parkinson's disease: synthesis, structure, neuroinflammatory, and neurodegenerative role	7
Correction to “Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells”	7
Variability in the levels of exosomal miRNAs among human subjects could be explained by differential interactions of exosomes with the endothelium	7
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Stem cell genes in atheromatosis: The role of Klotho, HIF1α, OCT4, and BMP4	7
Regulation of innate immune signaling pathways by autophagy in dengue virus infection	7
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KGF secreted from HSCs activates PAK4/BMI1, promotes HCC stemness through PI3K/AKT pathway	7
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The ins and outs of the flavin mononucleotide cofactor of respiratory complex I	7
Structure–function relationships between the human bitter taste receptor TAS2R38 and propylthiouracil: An in‐silico investigation	7
N1‐methyladenosine profiling of long non‐coding RNA in colorectal cancer	7
The role of SF3B1 and NOTCH1 in the pathogenesis of leukemia	6
1,25(OH)2D3 inhibits Lewis lung cancer cell migration via NHE1‐sensitive metabolic reprograming	6
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N‐acetylneuraminic acid modulates SQSTM1/p62 sialyation‐mediated ubiquitination degradation contributing to vascular endothelium dysfunction in experimental atherosclerosis mice	6
The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic inflammation	6
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The Saccharomyces cerevisiae mitochondrial DNA polymerase and its contribution to the knowledge about human POLG‐related disorders	6
Pore‐forming aegerolysin and MACPF proteins in extremotolerant or extremophilic fungi	6
Nano‐therapeutics: The upcoming nanomedicine to treat cancer	6
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The multifaceted antineoplastic role of pyrimethamine against human malignancies	6
Correction to “Astrakurkurone, a Sesquiterpenoid From Wild Edible Mushroom, Targets Liver Cancer Cells by Modulating Bcl‐2 Family Proteins”	6
Golgi quality control and autophagy	6
A decoy strategy to activate the immune system	6
CPEB1 enhances erastin‐induced ferroptosis in gastric cancer cells by suppressing twist1 expression	6
Erratum	6
Therapeutic Potential of Translational Readthrough at Disease‐Associated Premature Termination Codons From Tumor Suppressor Genes	6
Cofactors and pathogens: Flavin mononucleotide and flavin adenine dinucleotide (FAD) biosynthesis by the FAD synthase from Brucella ovis	6
Issue Highlights	6
FOXC2‐induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression	6
Issue Information	5
Correction to “LncRNA RAD51‐AS1/miR‐29b/c‐3p/NDRG2 crosstalk repressed proliferation, invasion and glycolysis of colorectal cancer”	5
The redox signal: A physiological perspective	5
Thiouracil and triazole conjugate induces autophagy through the downregulation of Wnt/β‐catenin signaling pathway in human breast cancer cells	5
Il‐6 and UGT1A1 variations may related to furosemide resistance in heart failure patients	5
Issue Information	5
Correction to “Retraction”	5
Mechanisms of adaptive hypertrophic cardiac remodeling in a large animal model of premature ventricular contraction‐induced cardiomyopathy	5
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Analyzing the role of ferroptosis in ribosome‐related bone marrow failure disorders: From pathophysiology to potential pharmacological exploitation	5
Tyrosine and Phenylalanine Activate Neuronal DNA Repair but Exhibit Opposing Effects on Global Transcription and Adult Female Mice Are Resilient to TyrRS/YARS1 Depleti	5
Corrigendum	4
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Ginkgolide C promotes apoptosis and abrogates metastasis of colorectal carcinoma cells by targeting Wnt/β‐catenin signaling pathway	4
Disrupted cellular calcium homeostasis is responsible for Aβ‐induced learning and memory damage and lifespan shortening in a model of Aβ transgenic fly	4
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Pyrimidine–triazole‐tethered tert‐butyl‐piperazine‐carboxylate suppresses breast cancer by targeting estrogen receptor signaling and β‐catenin activation	4
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Deciphering the senescence‐based tumoral heterogeneity and characteristics in pancreatic cancer: Results from parallel bulk and single‐cell transcriptome data	4
Biolistic transformation of the yeast Saccharomyces cerevisiae mitochondrial DNA	4
High cholesterol diet activates ER stress mediated apoptosis in testes tissue: Role of α‐tocopherol	4
Machine learning‐based establishment and validation of age‐related patterns for predicting prognosis in non‐small cell lung cancer within the context of the tumor microenvironment	4
Delivery of AKT1 phospho‐forms to human cells reveals differential substrate selectivity	4

Wnt signaling in cell adhesion, development, and colon cancer	4
Amyloid‐β40 E22K fibril in familial Alzheimer's disease is more thermostable and susceptible to seeding	4
The CD40/CD40 ligand dyad and its downstream effector molecule ISG54 in relating acute neuroinflammation with persistent, progressive demyelination	4
The long intergenic noncoding RNA ARES modulates root architecture in Arabidopsis	4
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Mimicking human riboflavin responsive neuromuscular disorders by silencing flad‐1 gene in C. elegans: Alteration of vitamin transport and cholinergic transmission	3
Melatonin effect on breast and ovarian cancers by targeting the PI3K/Akt/mTOR pathway	3
Issue Highlights	3
MRASin coronary artery disease—Unchartered territory	3
Humanized disulfide‐stabilized diabody against fibroblast growth factor‐2 inhibits PD‐L1 expression and epithelial‐mesenchymal transition in hepatoma cells through STAT3	3
Selectively targeting cancer stem cells: Current and novel therapeutic strategies and approaches in the effective eradication of cancer	3
p62 bodies: Phase separation, NRF2 activation, and selective autophagic degradation	3
Issue Information	3
Cyclin‐dependent kinase 7 is essential for spermatogenesis by regulating retinoic acid signaling pathways and the STAT3 molecular pathway	3
Hederagenol improves multiple sclerosis by modulating Th17 cell differentiation	3
Condition‐dependent structural collapse in the intrinsically disordered N‐terminal domain of prion protein	3
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Advancing Therapeutic Strategies for Nonsense‐Related Diseases: From Small Molecules to Nucleic Acid‐Based Innovations	3
Issue Highlights	3
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Reflections on the 50‐year history of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB)	3
Blood Coagulation Factor IX: Structure, Function, and Regulation	3
Mammalian iron sulfur cluster biogenesis and human diseases	3
Retraction: miR‐212/132 downregulates SMAD2 expression to suppress the G1/S phase transition of the cell cycle and the epithelial to mesenchymal transition in cervical	2
Mast cells: Therapeutic targets for COVID‐19 and beyond	2
Machine learning applications for transcription level and phenotype predictions	2
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Brucein D imparts a growth inhibitory effect in multiple myeloma cells by abrogating the Akt‐driven signaling pathway	2
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Intracellular innate immunity and mechanism of action of cytosolic nucleic acid receptor‐mediated type I IFN against viruses	2
Redefining pseudokinases: A look at the untapped enzymatic potential of pseudokinases	2
Contrast‐Induced Acute Kidney Injury is Modulated by Circadian CLOCK/NRF2 Pathway	2
Identification of novel key molecular signatures in the pathogenesis of experimental diabetic retinopathy	2
Neonatal exposure to low‐dose X‐ray causes behavioral defects and abnormal hippocampal development in mice	2
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Hypoxia inducible factor 3‐alpha promotes a malignant phenotype in colorectal cancer cells	2
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A high‐throughput approach to predict A‐to‐I effects on RNA structure indicates a change of double‐stranded content in noncoding RNAs	2
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miRNA‐128 and miRNA‐223 regulate cholesterol‐mediated drug resistance in breast cancer	2
The combination of midkine inhibitor with Lenvatinib amplifies the suppression of hepatocellular carcinoma	2
Zinc finger protein 169 promotes tumor progress of hepatocellular cancer via up‐regulating cyclin‐dependent kinase 19	2
MiR‐3680‐3p is a novel biomarker for the diagnosis and prognosis of liver cancer and is involved in regulating the progression of liver cancer	2
Cholesteryl ester transfer protein knock‐down in conjunction with a cholesterol‐depleting agent decreases tamoxifen resistance in breast cancer cells	2
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Involvement of sialoglycans in SARS‐COV‐2 infection: Opportunities and challenges for glyco‐based inhibitors	2
Single‐Cell Profiling of the Microenvironment in High‐Risk Neuroblastoma	2
miRNAs are now starring in “No Time to Die: Overcoming the chemoresistance in cancer”	2
Biosynthesis of uridine diphosphate N‐Acetylglucosamine: An underexploited pathway in the search for novel antibiotics?	2
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Mitochondrial E3 ubiquitin ligase 1 (MUL1) as a novel therapeutic target for diseases associated with mitochondrial dysfunction	2
Identification, subcellular localization, and functional comparison of novel Yap splicing isoforms in mouse embryonic stem cells	2
Aminoacyl‐tRNA synthetase defects in neurological diseases	2
KLHL38 facilitates staurosporine‐induced apoptosis in HL‐1 cells via myocardin degradation	2
Novel NRF2‐activated cancer treatments utilizing synthetic lethality	2
Enhancing the activation of T cells through anti‐CD3/CD28 magnetic beads by adjusting the antibody ratio	2
PD‐1/PD‐L1 blockade: Prospectives for immunotherapy in cancer and autoimmunity	1
The therapeutic effects of induced pluripotent stem cell‐derived mesenchymal stem cells on Parkinson's disease	1
Screening and experimental validation of diagnostic gene in ulcerative colitis with anti‐TNF‐α therapy	1
A hub for regulation of mitochondrial metabolism: Fatty acid and lipoic acid biosynthesis	1
Role of the initiation factor 3 in the fidelity of initiator tRNA selection on ribosome	1
Inorganic phosphate‐induced cytotoxicity	1
Fingolimod (FTY720), an FDA‐approved sphingosine 1‐phosphate (S1P) receptor agonist, restores endothelial hyperpermeability in cellular and animal models of dengue vir	1
Coexisting bacterial aminoacyl‐tRNAsynthetase paralogs exhibit distinct phylogenetic backgrounds and functional compatibility withEscherichia coli	1
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Differential expression of HNF1A and HNF1A‐AS1 in colon cancer cells	1
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The increased expression of cytokeratin 13 leads to an increase in radiosensitivity of nasopharyngeal carcinoma HNE‐3 cells by upregulating ERRFI1	1
Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect	1
A hybrid approach to assess the structural impact of long noncoding RNA mutations uncovers key NEAT1 interactions in colorectal cancer	1
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Functional TET2 gene polymorphisms increase the risk of neuroblastoma in Chinese children	1
Genetic tools to dissect functions of long noncoding RNAs	1
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Nuclear and cytoplasmic lncRNAs in root tips of the model legume Medicago truncatula under control and submergence	1
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Synergistic integration of deep learning with protein docking in cardiovascular disease treatment strategies	1
β‐Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts	1
CDKN3 as a key regulator of G2M phase in triple‐negative breast cancer: Insights from multi‐transcriptomic analysis	1
Phosphorylation, compartmentalization, and cardiac function	1
Rapamycin treatment unmasks a sex‐specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel	1
The latest achievements in biochemistry, biophysics and biotechnology—50 years of history of the Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków, Poland	1
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The scientific career and life of Edmond H. Fischer—A personal tribute	1
LncRTPred: Predicting RNA–RNA mode of interaction mediated by lncRNA	1
Histone demethylase LSD1 promotes castration‐resistant prostate cancer by causing widespread gene expression derangements	1
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m6A transferase KIAA1429‐stabilized LINC00958 accelerates gastric cancer aerobic glycolysis through targeting GLUT1	1
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Correction to “The latest achievements in biochemistry, biophysics and biotechnology—50 years of history of the Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Kraków	1
Investigation through naphtho[2,3‐a]pyrene on mutated EGFR mediated autophagy in NSCLC: Cellular model system unleashing therapeutic potential	1
Microtubule depolymerization induces ferroptosis in neuroblastoma cells	1