OOIR: Observatory of International Research

Papers

(The TQCC of IUBMB Life is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Bacterial co‐infections with SARS‐CoV‐2	195
Copper homeostasis: Emerging target for cancer treatment	145
The malate–aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway	118
Glucose‐regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders	50
N⁶‐methyladenosine modification of circular RNA circ‐ARL3 facilitates Hepatitis B virus‐associated hepatocellular carcinoma via sponging miR‐1305	46
Berberine: A novel therapeutic strategy for cancer	45
Toll‐like receptors (TLRs) in cancer; with an extensive focus on TLR agonists and antagonists	44
Toll‐like receptors in neuroinflammation, neurodegeneration, and alcohol‐induced brain damage	43
Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease	40
M2 macrophage‐derived exosomal miR‐25‐3p improves high glucose‐induced podocytes injury through activation autophagy via inhibiting DUSP1 expression	40
Expression level and diagnostic value of exosomal NEAT1/miR‐204/MMP‐9 in acute ST‐segment elevation myocardial infarction	39
Vitamin B12 may inhibit RNA‐dependent‐RNA polymerase activity of nsp12 from the SARS‐CoV‐2 virus	39
m⁶A transferase KIAA1429‐stabilized LINC00958 accelerates gastric cancer aerobic glycolysis through targeting GLUT1	39
Xanthohumol from Hop: Hope for cancer prevention and treatment	34
CircMMP1 promotes the progression of glioma through miR‐433/HMGB3 axis in vitro and in vivo	33
Structure, catalysis, and inhibition mechanism of prenyltransferase	33
One‐year mortality and consequences of COVID‐19 in cancer patients: A cohort study	31
m6A methyltransferase Wilms' tumor 1‐associated protein facilitates cell proliferation and cisplatin resistance in NK/T cell lymphoma by regulating dual‐specifici	31
Luteolin protects against testicular injury induced by lead acetate by activating the Nrf2/HO‐1 pathway	30
Role of microRNAs in Staphylococcus aureus infection: Potential biomarkers and mechanism	30
Identification of mutation resistance coldspots for targeting the SARS‐CoV2 main protease	29
Iron overload‐induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study	29
miR‐143 acts as an inhibitor of migration and proliferation as well as an inducer of apoptosis in melanoma cancer cells in vitro	28
SARS‐CoV‐2 multifaceted interaction with the human host. Part II: Innate immunity response, immunopathology, and epigenetics	28
The immunomodulatory effects of mesenchymal stromal cell‐based therapy in human and animal models of systemic lupus erythematosus	28

The apoptosis‐inducing factor family: Moonlighting proteins in the crosstalk between mitochondria and nuclei	28
Neuromelanins in brain aging and Parkinson's disease: synthesis, structure, neuroinflammatory, and neurodegenerative role	27
Circulating exosomal microRNAs as emerging non‐invasive clinical biomarkers in heart failure: Mega bio‐roles of a nano bio‐particle	27
Endoplasmic reticulum stress and NF‐kB activation in SARS‐CoV‐2 infected cells and their response to antiviral therapy	26
Exosomes derived from regulatory T cells ameliorate acute myocardial infarction by promoting macrophage M2 polarization	26
Long non‐coding RNAs as potential biomarkers in the prognosis and diagnosis of lung cancer: A review and target analysis	26
Crocetin imparts antiproliferative activity via inhibiting STAT3 signaling in hepatocellular carcinoma	26
LncRNA RAD51‐AS1/miR‐29b/c‐3p/NDRG2 crosstalk repressed proliferation, invasion and glycolysis of colorectal cancer	25
Hormesis: Transforming disciplines that rely on the dose response	25
Combination of metformin and chlorogenic acid attenuates hepatic steatosis and inflammation in high‐fat diet fed mice	24
Exosomes derived from T regulatory cells relieve inflammatory bowel disease by transferring miR‐195a‐3p	24
T‐cell immunoglobulin and ITIM domain, as a potential immune checkpoint target for immunotherapy of colorectal cancer	23
Expression levels of miR‐27a, miR‐329, ABCA1, and ABCG1 genes in peripheral blood mononuclear cells and their correlation with serum levels of	23
ATF4‐modified serum exosomes derived from osteoarthritic mice inhibit osteoarthritis by inducing autophagy	23
Pro‐inflammatory role of cell‐free mitochondrial DNA in cardiovascular diseases	22
Interleukin‐22 and intestinal homeostasis: Protective or destructive?	22
Long non‐coding RNA NORAD functions as a microRNA‐204‐5p sponge to repress the progression of Parkinson's disease in vitro by increasing the solute carrier family 5 member 3 expr	22
Mitophagy in aging and longevity	22
Soy isoflavone genistein inhibits hsa_circ_0031250/miR‐873‐5p/FOXM1 axis to suppress non‐small‐cell lung cancer progression	22
Oleuropein protects against lipopolysaccharide‐induced sepsis and alleviates inflammatory responses in mice	21
Oxidized low‐density lipoprotein accelerates the injury of endothelial cells via circ‐USP36/miR‐98‐5p/VCAM1 axis	21
Brain‐targeted co‐delivery of β‐amyloid converting enzyme 1 shRNA and epigallocatechin‐3‐gallate by multifunctional nanocarriers for Alzheimer's disease treatment	20
Iron accumulation regulates osteoblast apoptosis through lncRNAXIST/miR‐758‐3p/caspase 3 axis leading to osteoporosis	20
Mitochondrial transport and metabolism of the vitamin B‐derived cofactors thiamine pyrophosphate, coenzyme A,FADandNAD⁺, and related diseases: A review	20
Inhibition of microRNA‐9‐5p and microRNA‐128‐3p can inhibit ischemic stroke‐related cell death in vitro and in vivo	20
The PI3K/Akt/mTORC signaling axis in head and neck squamous cell carcinoma: Possibilities for therapeutic interventions either as single agents or in combination with conventional therapies	19
Targeting amino acid metabolism of Mycobacterium tuberculosis for developing inhibitors to curtail its survival	18
CPEB1 enhances erastin‐induced ferroptosis in gastric cancer cells by suppressing twist1 expression	18
Shedding more light on the role of Midkine in hepatocellular carcinoma: New perspectives on diagnosis and therapy	18
Mitochondria and nucleus cross‐talk: Signaling in metabolism, apoptosis, and differentiation, and function in cancer	18
Naringin‐generated ROS promotes mitochondria‐mediated apoptosis in Candida albicans	18
The potential therapeutic effects of curcumin on pregnancy complications: Novel insights into reproductive medicine	18
Circ_0072088 promotes progression of hepatocellular carcinoma by activating JAK2/STAT3 signaling pathway via miR‐375	17
Mitochondrial–nuclear p53 trafficking controls neuronal susceptibility in stroke	17
The effect of Chinese herbal medicine on digestive system and liver functions should not be neglected in COVID‐19: An updated systematic review and meta‐analysis	17
MiR‐134‐5p targeting XIAP modulates oxidative stress and apoptosis in cardiomyocytes under hypoxia/reperfusion‐induced injury	17
MiR‐770 promotes oral squamous cell carcinoma migration and invasion by regulating the Sirt7/Smad4 pathway	17
Gastrointestinal tissue as a “new” target of pollution exposure	17
Not all mitochondrial DNAs are made equal and the nucleus knows it	17
FOXO transcription factors in antioxidant defense	17
DNMT1 maintains the methylation of miR‐152‐3p to regulate TMSB10 expression, thereby affecting the biological characteristics of colorectal cancer cells	16
Reference intervals for routine biochemical markers and body mass index: A study based on healthcare center database in northeastern Iran	16
2‐Deoxy‐d‐glucose exploits increased glucose metabolism in cancer and viral‐infected cells: Relevance to its use in India against SARS‐CoV‐2	16
Small nucleolar RNA host genes promoting epithelial–mesenchymal transition lead cancer progression and metastasis	16
miR‐543 in human mesenchymal stem cell–derived exosomes promotes cardiac microvascular endothelial cell angiogenesis after myocardial infarction through COL4A1	16
lncRNA ZEB2‐AS1: A promising biomarker in human cancers	15
Impact of supplementation with vitamins B₆, B₁₂, and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A sys	15
Role of PIWI‐interacting RNAs on cell survival: Proliferation, apoptosis, and cycle	15
Knockdown of lncRNA TTTY15 alleviates myocardial ischemia–reperfusion injury through the miR‐374a‐5p/FOXO1 axis	15
The key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions	15

Combined effect of chrysin and apigenin on inhibiting the development and progression of colorectal cancer by suppressing the activity of P38‐MAPK/AKT pathway	15
Long noncoding RNA small nucleolar RNA host gene 15 deteriorates liver cancer via microRNA‐18b‐5p/LIM‐only 4 axis	14
Roles of IL‐1 and IL‐10 family cytokines in the progression of systemic lupus erythematosus: Friends or foes?	14
The mechanism research on the anti‐liver fibrosis of emodin based on network pharmacology	14
miR‐141‐3p inhibits vascular smooth muscle cell proliferation and migration via regulating Keap1/Nrf2/HO‐1 pathway	14
Nuclear‐mitochondrial crosstalk: On the role of the nuclear receptor liver receptor homolog‐1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival, and cancer	14
Angiotensin‐converting enzyme 2: A protective factor in regulating disease virulence of SARS‐COV‐2	14
Let‐7b‐5p is involved in the response of endoplasmic reticulum stress in acute pulmonary embolism through upregulating the expression of stress‐associated endoplasmic reticulum protein 1	13
HOXA5 induces M2 macrophage polarization to attenuate carotid atherosclerosis by activating MED1	13
The halogenation of natural flavonoids, baicalein and chrysin, enhances their affinity to human protein kinase CK2	13
Gliclazide attenuates cisplatin‐induced nephrotoxicity through inhibiting NF‐κB and caspase‐3 activity	13
Kinetochore‐catalyzed MCC formation: A structural perspective	13
Desaturases: Structural and mechanistic insights into the biosynthesis of unsaturated fatty acids	13
Homeostatic control of redox status and health	13
Cancer combination therapies by silencing of CTLA‐4, PD‐L1, and TIM3 in osteosarcoma	13
Mass production of active recombinant Chryseobacterium proteolyticum protein glutaminase in Escherichia coli using a sequential dual expression system and one‐step	13
Influence of plasma circulating exosomes obtained from obese women on tumorigenesis and tamoxifen resistance in MCF‐7 cells	13
Long non‐coding RNA uc.80‐ overexpression promotes M2 polarization of microglias to ameliorate depression in rats	13
LncRNA UCA1 remits LPS‐engendered inflammatory damage through deactivation of miR‐499b‐5p/TLR4 axis	13
Epigenetic targeting of SLC30A3 by HDAC1 is related to the malignant phenotype of glioblastoma	13
Gallic acid‐gold nanoparticles enhance radiation‐induced cell death of human glioma U251 cells	13
Autophagy drives plasticity and functional polarization of tumor‐associated macrophages	13
Tea bioactive components prevent carcinogenesis via anti‐pathogen, anti‐inflammation, and cell survival pathways	12
Analysis of the expression profile of long non‐coding RNAs MALAT1 and THRIL in children with immune thrombocytopenia	12
N1‐methyladenosine profiling of long non‐coding RNA in colorectal cancer	12
Knockdown of ST6Gal‐I expression in human hepatocellular carcinoma cells inhibits their exosome‐mediated proliferation‐ and migration‐promoting effects	12
p62 bodies: Phase separation, NRF2 activation, and selective autophagic degradation	12
Long non‐coding RNA LINC01207 promotes prostate cancer progression by downregulating microRNA‐1972 and upregulating LIM and SH3 protein 1	11
Schizandrin A inhibits cellular phenotypes of breast cancer cells by repressing miR‐155	11
CP‐25 exerts therapeutic effects in mice with dextran sodium sulfate‐induced colitis by inhibiting GRK2 translocation to downregulate the TLR4‐NF‐κB‐NLRP3 inflammasome	11
Silencing of long non‐coding RNADLX6‐AS1 weakens neuroblastoma progression by the miR‐513c‐5p/PLK4 axis	11
Ursolic acid ameliorates hypobaric hypoxia‐induced skeletal muscle protein loss via upregulating Akt pathway: An experimental study using rat model	11
Melatonin as a potential inhibitor of kidney cancer: A survey of the molecular processes	11
Mitochondrial E3 ubiquitin ligase 1 (MUL1) as a novel therapeutic target for diseases associated with mitochondrial dysfunction	11
Cholesterol‐dependent cytolysins: The outstanding questions	11
SMARCAL1, the annealing helicase and the transcriptional co‐regulator	11
Ginkgolide C promotes apoptosis and abrogates metastasis of colorectal carcinoma cells by targeting Wnt/β‐catenin signaling pathway	11
Circ_0109046 promotes the malignancy of endometrial carcinoma cells through the microRNA‐105/SOX9/Wnt/β‐catenin axis	11
Half a century of bacteriophage lambda recombinase: In vitro studies of lambda exonuclease and Red‐beta annealase	11
PD‐1/PD‐L1 blockade: Prospectives for immunotherapy in cancer and autoimmunity	10
TAR DNA‐binding protein 43 oligomers in physiology and pathology	10
An overview of the innate and adaptive immune system in atherosclerosis	10
Mast cells: Therapeutic targets for COVID‐19 and beyond	10
CircPDE4B inhibits retinal pathological angiogenesis via promoting degradation of HIF‐1α though targeting miR‐181c	10
Neopterin serum level does not reflect the disease activity in rheumatoid arthritis: A systematic review and meta‐analysis	10
The multifaceted antineoplastic role of pyrimethamine against human malignancies	10
LMNB2 is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma	10
Epigenetic transcripts of LINC01311 and hsa‐miR‐146a‐5p regulate neural development in a cellular model of Alzheimer's disease	10
Histone deacetylase 10 exerts antitumor effects on cervical cancer via a novel microRNA‐223/TXNIP/Wnt/β‐catenin pathway	10
SARS‐CoV‐2 multifaceted interaction with human host. Part I: What we have learnt and done so far, and the still unknown realities	10
Periplocin induces apoptosis and inhibits inflammation in rheumatoid arthritis fibroblast‐like synoviocytes via nuclear factor kappa B pathway	9
The mechanism of sitagliptin inhibition of colorectal cancer cell lines' metastatic functionalities	9
MiR‐1224‐5p acts as a tumor suppressor via inhibiting the malignancy of rectal cancer through targeting SLC29A3	9
Mitochondrial iron and calcium homeostasis in Friedreich ataxia	9
Long noncoding RNA PWRN1 is lowly expressed in osteosarcoma and modulates cancer proliferation and migration by targeting hsa‐miR‐214‐5p	9
Urinary proteomic analysis to identify a potential protein biomarker panel for the diagnosis of tuberculosis	9
Current status and perspectives regarding the association between allergic disorders and cancer	9
Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes	9
Bromodomain‐containing protein 9 is a prognostic biomarker associated with immune infiltrates and promotes tumor malignancy through activating notch signaling pathway in negative HIF‐2α cle	9
Enhancer of zeste homolog 2 participates in the process of atherosclerosis by modulating microRNA‐139‐5p methylation and signal transducer and activator of transcription 1 expres	9
Evaluating the therapeutic efficacy of radiolabeled BSA@CuS nanoparticle‐induced radio‐photothermal therapy against anaplastic thyroid cancer	9
Autophagy and antiviral defense	9
Central nervous system cholesterol metabolism in health and disease	9
The lethal internal face of the coronaviruses: Kidney tropism of the SARS, MERS, and COVID19 viruses	9