Clinical Immunology

Article	Citations
COVID-19 pathophysiology: A review	1299
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China	923
COVID-19: Immunology and treatment options	450
Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases	412
The first case of COVID-19 treated with the complement C3 inhibitor AMY-101	236
Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy	211
Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients	199
Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic	186
Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy	182
COVID-19: A review of therapeutic strategies and vaccine candidates	172
Do COVID-19 RNA-based vaccines put at risk of immune-mediated diseases? In reply to “potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in aut	154
The efficacy of PD-1/PD-L1 blockade in cold cancers and future perspectives	132
Selective CD8 cell reduction by SARS-CoV-2 is associated with a worse prognosis and systemic inflammation in COVID-19 patients	124
The IL-2 – IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor	120
Potential effect of blood purification therapy in reducing cytokine storm as a late complication of critically ill COVID-19	118
Type 3 hypersensitivity in COVID-19 vasculitis	115
COVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potential	115
On the molecular determinants of the SARS-CoV-2 attack	110
Therapeutic blockade of inflammation in severe COVID-19 infection with intravenous N-acetylcysteine	105
Interrelations between COVID-19 and other disorders	103
Influenza infection, SARS, MERS and COVID-19: Cytokine storm – The common denominator and the lessons to be learned	100
Anti-complement C5 therapy with eculizumab in three cases of critical COVID-19	99
Recent advances on signaling pathways and their inhibitors in rheumatoid arthritis	96
Neurologic adverse events among 704,003 first-dose recipients of the BNT162b2 mRNA COVID-19 vaccine in Mexico: A nationwide descriptive study	83
SARS-CoV-2 infections in children and young people	81

Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution!	81
Comorbidities associated with psoriatic arthritis: Review and update	81
Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19	80
Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients	79
Micronutrients as immunomodulatory tools for COVID-19 management	76
Inhibition of cytokine signaling by ruxolitinib and implications for COVID-19 treatment	68
Treating COVID-19 with colchicine in community healthcare setting	66
Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy	64
Guillain-Barré syndrome is infrequent among recipients of the BNT162b2 mRNA COVID-19 vaccine	59
Characterization of PANoptosis patterns predicts survival and immunotherapy response in gastric cancer	59
Laboratory biomarkers associated with COVID-19 severity and management	51
Development of child immunity in the context of COVID-19 pandemic	48
Galectin-3 regulates microglial activation and promotes inflammation through TLR4/MyD88/NF-kB in experimental autoimmune uveitis	46
COVID-19 in a patient with long-term use of glucocorticoids: A study of a familial cluster	46
Covid-19 vaccine and autoimmunity: Awakening the sleeping dragon	45
Hydroxychloroquine inhibiting neutrophil extracellular trap formation alleviates hepatic ischemia/reperfusion injury by blocking TLR9 in mice	45
Genetic justification of severe COVID-19 using a rigorous algorithm	45
COVID-19 – Considerations for the paediatric rheumatologist	42
Use of CAR-T cell therapy, PD-1 blockade, and their combination for the treatment of hematological malignancies	41
Major reduction of NKT cells in patients with severe COVID-19 pneumonia	40
Activation of classical and alternative complement pathways in the pathogenesis of lung injury in COVID-19	40
Natural killer cells play an important role in virus infection control: Antiviral mechanism, subset expansion and clinical application	39
Identification of critical ferroptosis regulators in lung adenocarcinoma that RRM2 facilitates tumor immune infiltration by inhibiting ferroptotic death	36
Imatinib for COVID-19: A case report	35
A framework for understanding Kawasaki disease pathogenesis	34
Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients	33
The microbiota-mediated dietary and nutritional interventions for COVID-19	33
Macrophages in tumor: An inflammatory perspective	33
TNF-α pathway and T-cell immunity are activated early during the development of diabetic nephropathy in Type II Diabetes Mellitus	32
Long-term infection of SARS-CoV-2 changed the body's immune status	32
On the genetics and immunopathogenesis of COVID-19	32
Treatment of B-cell depleted COVID-19 patients with convalescent plasma and plasma-based products	31
Challenges in the clinical diagnosis of psoriatic arthritis	31
Dupilumab to treat severe atopic dermatitis in autosomal dominant hyper-IgE syndrome	29
Effective DNA damage response after acute but not chronic immune challenge: SARS-CoV-2 vaccine versus Systemic Lupus Erythematosus	28
Lupus gut microbiota transplants cause autoimmunity and inflammation	28
ROCK2, a critical regulator of immune modulation and fibrosis has emerged as a therapeutic target in chronic graft-versus-host disease	28
Gut dysbiosis and multiple sclerosis	28
Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19	27
Anaphylaxis associated with the mRNA COVID-19 vaccines: Approach to allergy investigation	27
Update on the cellular and molecular aspects of lupus nephritis	27
Type I interferon-independent T cell impairment in a Tmem173 N153S/WT mouse model of STING associated vasculopathy with onset in infancy (SAVI)	26
Longitudinal observation of antibody responses for 14 months after SARS-CoV-2 infection	26
An enlightening role for cytokine storm in coronavirus infection	26
From discovery to approval: A brief history of the compstatin family of complement C3 inhibitors	26
COVID-19-related health outcomes in people with primary immunodeficiency: A systematic review	24
Polyarteritis nodosa and deficiency of adenosine deaminase 2 – Shared genealogy, generations apart	24
Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults	24
Vitamin D suppress the production of vascular endothelial growth factor in mast cell by inhibiting PI3K/Akt/p38 MAPK/HIF-1α pathway in chronic spontaneous urticaria	24
Adult-onset Still's disease following mRNA COVID-19 vaccination	24

Long non-coding RNA Xist contribution in systemic lupus erythematosus and rheumatoid arthritis	23
The resurgence of a neglected orthopoxvirus: Immunologic and clinical aspects of monkeypox virus infections over the past six decades	23
Coronavirus-induced autoimmunity	22
Current insights and future prospects for the pathogenesis and treatment for rheumatoid arthritis	22
Patients with autoimmune polyendocrine syndrome type 1 have an increased susceptibility to severe herpesvirus infections	22
T cell dysregulation in SLE	21
Racial disparity in Covid-19 mortality rates - A plausible explanation	21
Transcriptional changes in peanut-specific CD4+ T cells over the course of oral immunotherapy	21
Systemic lupus erythematosus as a genetic disease	21
Behçet's disease with a somatic UBA1 variant:Expanding spectrum of autoinflammatory phenotypes of VEXAS syndrome	21
Whole exome sequencing (WES) approach for diagnosing primary immunodeficiencies (PIDs) in a highly consanguineous community	20
Gut microbiota in chronic inflammatory disorders: A focus on pediatric inflammatory bowel diseases and juvenile idiopathic arthritis	20
Transcriptome of airway neutrophils reveals an interferon response in life-threatening respiratory syncytial virus infection	20
Exosome-mediated circ_0001846 participates in IL-1β-induced chondrocyte cell damage by miR-149-5p-dependent regulation of WNT5B	20
The role of A-to-I RNA editing in infections by RNA viruses: Possible implications for SARS-CoV-2 infection	20
PD-1 signaling pathway in sepsis: Does it have a future?	20
SARS-CoV-2 infection associated with hepatitis in an infant with X-linked severe combined immunodeficiency	20
TNF-inhibitors or bisphosphonates in chronic nonbacterial osteomyelitis? - Results of an international retrospective multicenter study	20
Infection-induced myeloperoxidase specific antineutrophil cytoplasmic antibody (MPO-ANCA) associated vasculitis: A systematic review	20
DNA methylation signatures of autoimmune diseases in human B lymphocytes	20
Immune modulating effects of receptor interacting protein 2 (RIP2) in autoinflammation and immunity	19
Subgroup analysis of nelipepimut-S plus GM-CSF combined with trastuzumab versus trastuzumab alone to prevent recurrences in patients with high-risk, HER2 low-expressing breast cancer	19
Serum levels of SARS-CoV-2 nucleocapsid antigen associate with inflammatory status and disease severity in COVID-19 patients	19
SARS-CoV-2/COVID-19 and its relationship with NOD2 and ubiquitination	19
Role of NRF2 and Sirtuin activators in COVID-19	19
Treg-dependent immunosuppression triggers effector T cell dysfunction via the STING/ILC2 axis	19
Mesenchymal stem cell alongside exosomes as a novel cell-based therapy for COVID-19: A review study	19
Reactogenicity of a third BNT162b2 mRNA COVID-19 vaccine among immunocompromised individuals and seniors - A nationwide survey	19
Immunogenicity of SARS-CoV-2 vaccination in rituximab-treated patients: Effect of timing and immunologic parameters	19
Immune checkpoint inhibition for the treatment of cancers: An update and critical review of ongoing clinical trials	19
Dynamics of HIV reservoir decay and naïve CD4 T-cell recovery between immune non-responders and complete responders on long-term antiretroviral treatment	19
T cell markers recount the course of immunosenescence in healthy individuals and chronic kidney disease	18
Abatacept for treatment-refractory pediatric CTLA4-haploinsufficiency	18
Atezolizumab and blockade of LncRNA PVT1 attenuate cisplatin resistant ovarian cancer cells progression synergistically via JAK2/STAT3/PD-L1 pathway	18
Can Ticagrelor be used to prevent sepsis-induced coagulopathy in COVID-19?	18
IL-21+ CD4+ T helper cells co-expressing IFN-γ and TNF-α accumulate in the joints of antinuclear antibody positive patients with juvenile idiopathic arthritis	18
Capsaicin alleviates acetaminophen-induced acute liver injury in mice	18
How to overcome tumor resistance to anti-PD-1/PD-L1 therapy by immunotherapy modifying the tumor microenvironment in MSS CRC	18
Differential analysis of serum and urine S100 proteins in juvenile-onset systemic lupus erythematosus (jSLE)	18
Prognostic impact of toll-like receptors gene polymorphism on outcome of COVID-19 pneumonia: A case-control study	18
Biological effect of PM10 on airway epithelium-focus on obstructive lung diseases	18
Common hematological values predict unfavorable outcomes in hospitalized COVID-19 patients	17
Antibody-dependent enhancement and COVID-19: Moving toward acquittal	17
Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis	17
Combination of multiple tumor-infiltrating immune cells predicts clinical outcome in colon cancer	17
Immunostaining of galactose-deficient IgA1 by KM55 is not specific for immunoglobulin A nephropathy	17
The critical role of short-chain fatty acids in health and disease: A subtle focus on cardiovascular disease-NLRP3 inflammasome-angiogenesis axis	17
Role of diet in regulating the gut microbiota and multiple sclerosis	17
Phenotypic characterization of tumor CTLA-4 expression in melanoma tissues and its possible role in clinical response to Ipilimumab	16
Fungal infections in primary immunodeficiency diseases	16
Evaluation of serological anti-SARS-CoV-2 chemiluminescent immunoassays correlated to live virus neutralization test, for the detection of anti-RBD antibodies as a relevant alternative in COVID-19 lar	16
Improvement of renal and non-renal SLE outcome measures on sirolimus therapy – A 21-year follow-up study of 73 patients	16
Complement activation and increased expression of Syk, mucin-1 and CaMK4 in kidneys of patients with COVID-19	16
Updated therapies for the management of Psoriatic Arthritis	16
Prolonged intraocular residence and retinal tissue distribution of a fourth-generation compstatin-based C3 inhibitor in non-human primates	16
Myeloid-derived suppressor cells in COVID-19: A review	16
N6-methyladenosine demethylase FTO regulates inflammatory cytokine secretion and tight junctions in retinal pigment epithelium cells	16
Association of KIR gene polymorphisms with COVID-19 disease	16
Seven novel podocyte autoantibodies were identified to diagnosis a new disease subgroup-autoimmune Podocytopathies	16
Systemic lupus erythematosus – Are children miniature adults?	16
Effectiveness and safety of intravenous tocilizumab to treat COVID-19-associated hyperinflammatory syndrome: Covizumab-6 observational cohort	16
Circ_0001103 alleviates IL-1β-induced chondrocyte cell injuries by upregulating SIRT1 via targeting miR-375	16
Juvenile-onset Behçet's syndrome and mimics	16
Chronic non-bacterial osteomyelitis and autoinflammatory bone diseases	15
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19	15
Classification of systemic lupus erythematosus in children and adults	15
Checkpoint inhibitors (CPI) and autoimmune chronic inflammatory diseases (ACIDs): tolerance and loss of tolerance in the occurrence of immuno-rheumatologic manifestations	15
Association of cardiometabolic risk status with clinical activity and damage in systemic lupus erythematosus patients: A cross-sectional study	15
Health-related quality of life in primary immunodeficiencies: Impact of delayed diagnosis and treatment burden	15
Early prediction of COVID-19 outcome using artificial intelligence techniques and only five laboratory indices	15
COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era	15
Significance of KIR like natural killer cell receptors in autoimmune disorders	15
Two siblings presenting with novel ADA2 variants, lymphoproliferation, persistence of large granular lymphocytes, and T-cell perturbations	15
Fatal SARS-CoV-2 infection in a male patient with Good's syndrome	15
Proinflammatory cytokines are associated with prolonged viral RNA shedding in COVID-19 patients	15
Targeting immunometabolism against acute lung injury	14
Psoriatic arthritis in childhood: A commentary on the controversy	14
Combined administration of inhaled DNase, baricitinib and tocilizumab as rescue treatment in COVID-19 patients with severe respiratory failure	14
PARP14 promotes the growth and glycolysis of acute myeloid leukemia cells by regulating HIF-1α expression	14
Foxp3+ Tregs from Langerhans cell histiocytosis lesions co-express CD56 and have a definitively regulatory capacity	14

Cardiac pathology and outcomes vary between Kawasaki disease and PIMS-TS	14
Protracted stress-induced hypocortisolemia may account for the clinical and immune manifestations of Long COVID	14
Interleukin 4 promotes anti-inflammatory macrophages that clear cartilage debris and inhibits osteoclast development to protect against osteoarthritis	14
Protective HLA alleles against severe COVID-19: HLA-A*68 as an ancestral protection allele in Tapachula-Chiapas, Mexico	14
Effect of monoclonal antibody therapy on the endogenous SARS-CoV-2 antibody response	14
Impact of the COVID-19 pandemic in patients with systemic lupus erythematosus throughout one year	14
Utilization of intravenous or subcutaneous immunoglobulins in secondary immune deficiency (ULTIMATE): A retrospective multicenter study	14
Allergic skin inflammation and S. aureus skin colonization are mutually reinforcing	14
BTK inhibitors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): A systematic review	14
Exhaustion and over-activation of immune cells in COVID-19: Challenges and therapeutic opportunities	14
New laboratory criteria of the autoimmune inflammation in pulmonary sarcoidosis and tuberculosis	13
Stem cell like memory T cells: A new paradigm in cancer immunotherapy	13
Mumps virus-specific immune response outcomes and sex-based differences in a cohort of healthy adolescents	13
X-linked inhibitor of apoptosis protein deficiency complicated with Crohn's disease-like enterocolitis and Takayasu arteritis: A case report	13
Novel T cell interferon gamma release assay (IGRA) using spike recombinant protein for COVID19 vaccine response and Nucleocapsid for SARS-Cov2 response	13
IL-27: An endogenous constitutive repressor of human monocytes	13
Prognostic value of a nine-gene signature in glioma patients based on tumor-associated macrophages expression profiling	13
Expression, regulation and clinical significance of B7-H3 on neutrophils in human gastric cancer	13
A simple and highly efficient method of IFI44L methylation detection for the diagnosis of systemic lupus erythematosus	13
The cutaneous and intestinal microbiome in psoriatic disease	13
A plea for the pathogenic role of immune complexes in severe Covid-19	13
Recent genetic advances in innate immunity of psoriatic arthritis	13
SARS-CoV-2 proteins regulate inflammatory, thrombotic and diabetic responses in human arterial fibroblasts	13
Where we are with acquired angioedema due to C1 inhibitor deficiency: A systematic literature review	12
Immunophenotyping reveals distinct subgroups of lupus patients based on their activated T cell subsets	12
The safety of long-term use of inhaled corticosteroids in patients with asthma: A systematic review and meta-analysis	12
Platelet bound complement split product (PC4d) is a marker of platelet activation and arterial vascular events in Systemic Lupus Erythematosus	12
Intestinal microbiome transfer, a novel therapeutic strategy for COVID-19 induced hyperinflammation?	12
The impaired anti-tumoral effect of immune surveillance cells in the immune microenvironment of gastric cancer	12
Anti-inflammatory and immune therapy in severe coronavirus disease 2019 (COVID-19) patients: An update	12
Farnesol induces protection against murine CNS inflammatory demyelination and modifies gut microbiome	12
Long-term cognitive deficits after traumatic brain injury associated with microglia activation	12
Curb complement to cure COVID-19	12
Therapeutic agents affecting the immune system and drug-induced inflammatory bowel disease (IBD): A review on etiological and pathogenetic aspects	12
Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis	12
Health-related quality of life in patients with immune mediated inflammatory diseases: A cross-sectional, multidisciplinary study	12
Identification of a potent regulatory T cell epitope in factor V that modulates CD4+ and CD8+ memory T cell responses	12
mTOR signaling: A pivotal player in Treg cell dysfunction in systemic lupus erythematosus	11
Ectopic lymphoid structures in the aged lacrimal glands	11
Anti-SARS-CoV-2 antibody detection in healthcare workers of two tertiary hospitals in Athens, Greece	11
Differential expression of TIM-3 in circulation and tumor microenvironment of colorectal cancer patients	11
Immunoglobulin free light chains as an inflammatory biomarker of heart failure with myocarditis	11
The impact of BCG dose and revaccination on trained immunity	11
Recent insights into the impact of immune dysfunction on reproduction in autoimmune thyroiditis	11
Epithelial-macrophage-dendritic cell interactions impact alarmins expression in asthma and COPD	11
Aberrant monocyte subsets in patients with Behçet's disease	11
Sicca syndrome following immune checkpoint inhibition	11
Determination of neutralising anti-SARS-CoV-2 antibody half-life in COVID-19 convalescent donors	11
Potential of immunotherapies in the mediation of antileukemic responses for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) - With a focus on Dendritic cells of leukemic	11
Psoriatic arthritis under the influence of IFNγ	11
A novel application of delayed-type hipersensitivity reaction to measure cellular immune response in SARS-CoV-2 exposed individuals	11
Immunological features of circulating monocyte subsets in patients with squamous cell carcinoma of the head and neck	11
T cell receptor repertoire as a potential diagnostic marker for celiac disease	11
Invasive fungal disease and the immunocompromised host including allogeneic hematopoietic cell transplant recipients: Improved understanding and new strategic approach with sargramostim	11
Circulating dendritic cells are severely decreased in idiopathic pulmonary fibrosis with a potential value for prognosis prediction	11
RNA-seq characterization of histamine-releasing mast cells as potential therapeutic target of osteoarthritis	10
Efficacy of tofacitinib for slowly progressive interstitial lung disease in a patient with anti-MDA5 antibody-positive dermatomyositis	10
Unconventional T cells – New players in antifungal immunity	10
Autoantibody signatures discovered by HuProt protein microarray to enhance the diagnosis of lung cancer	10
A strategy targeting monocyte-macrophage differentiation to avoid pulmonary complications in SARS-Cov2 infection	10
Immune evasion and chronological decrease in titer of neutralizing antibody against SARS-CoV-2 and its variants of concerns in COVID-19 patients	10
Effects of dietary restriction on gut microbiota and CNS autoimmunity	10
Novel biallelic mutations in the DUOX2 gene underlying very early-onset inflammatory bowel disease: A case report	10
Immunologic and dose dependent effects of rapamycin and its evolving role in chemoprevention	10
A global survey in the developmental landscape of possible vaccination strategies for COVID-19	10
The FCGR2A rs1801274 polymorphism was associated with the risk of death among COVID-19 patients	10
RIP2 knockdown inhibits cartilage degradation and oxidative stress in IL-1β-treated chondrocytes via regulating TRAF3 and inhibiting p38 MAPK pathway	10
Paediatric MAS/HLH caused by a novel monoallelic activating mutation in p110δ	9
Allogeneic hematopoietic cell transplantation in the management of GATA2 deficiency and pulmonary alveolar proteinosis	9
Not your average joint: Towards precision medicine in psoriatic arthritis	9
How autoinflammation may turn into autoimmune inflammation: Insights from monogenetic and complex IL-1 mediated auto-inflammatory diseases	9
Expression and clinical significance of VISTA, B7-H3, and PD-L1 in glioma	9
B-cell oligoclonal expansions in renal tissue of patients with immune-mediated glomerular disease	9
Memory and naïve gamma delta regulatory T-cell gene expression in the first 24-weeks of peanut oral immunotherapy	9
A novel intracellular nanobody against HPV16 E6 oncoprotein	9
Clinical, immunological, molecular and therapeutic findings in monogenic immune dysregulation diseases: Middle East and North Africa registry	9
Advances in the treatment of severe combined immunodeficiency	9
Immunogenicity and reactogenicity of homologous mRNA-based and vector-based SARS-CoV-2 vaccine regimens in patients receiving maintenance dialysis	9
Critical COVID-19 disease, homeostasis, and the “surprise” of effective glucocorticoid therapy	9
Cancer germline antigen gene MAGEB2 promotes cell invasion and correlates with immune microenvironment and immunotherapeutic efficiency in laryngeal cancer	9
Expression of APOBEC family members as regulators of endogenous retroelements and malignant transformation in systemic autoimmunity	9
Tissue distribution of γδ T cell subsets in oesophageal adenocarcinoma	9
Severe COVID-19 pneumonia in Good syndrome with a favorable outcome	9
ADA2 deficiency complicated by EBV-driven lymphoproliferative disease	9
Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19	9
The pro-inflammatory effect of triglyceride on human CD4+ T cells and experimental autoimmune uveitis	9
Endoplasmic reticulum stress exacerbates inflammation in chronic rhinosinusitis with nasal polyps via the transcription factor XBP1	9
Differential response induced by LPS and MPLA in immunocompetent and septic individuals	9
Mycoplasma infection may complicate the clinical course of SARS-Co-V-2 associated Kawasaki-like disease in children	9
IL-4 receptor blockade is a global repressor of naïve B cell development and responses in a dupilumab-treated patient	8
BCL10 loss-of-function novel mutation leading to atypical severe combined immunodeficiency	8
Infection with SARS-CoV-2 primes immunological memory in human nasal-associated lymphoid tissue	8
Treatment of antiphospholipid syndrome	8
Ex vivo assays to detect complement activation in complementopathies	8
SAP interacts with CD28 to inhibit PD-1 signaling in T lymphocytes	8