American Journal of Physiology-Renal Physiology

Article	Citations
First Author Highlights	72
First Author Highlights	51
First Author Highlights	47
Exercise sensitizes the pressure diuresis response: shifting immune landscapes may underlie renal adaptations	44
Role of the CDKL1-SOX11 signaling axis in acute kidney injury	39
Distinct developmental reprogramming footprint of macrophages during acute kidney injury across species	38
Corrigendum for Jang et al., volume 326, 2024, p. F69	35
C-terminal fragment of fibroblast growth factor 23 improves heart function in murine models of high intact fibroblast growth factor 23	34
Expression of leptin receptor in renal tubules is sparse but implicated in leptin-dependent kidney gene expression and function	33
Perinatal asphyxia leads to acute kidney damage and increased renal susceptibility in adulthood	31
Small hairpin inhibitory RNA delivery in the metanephric organ culture identifies long noncoding RNA Pvt1 as a modulator of cyst growth	30
“Idiopathic” minimal change nephrotic syndrome: a podocyte mystery nears the end	29
Chronic infusion of the tryptophan metabolite kynurenine increases mean arterial pressure in male Sprague-Dawley rats	29
Interleukin-6 blockade reduces salt-induced cardiac inflammation and fibrosis in subtotal nephrectomized mice	29
Stimulation of basolateral calcium-sensing receptor inhibits Kir4.1/Kir5.1 in the mouse distal convoluted tubule	29
Accuracy and processing time of kidney volume measurement methods in rodents polycystic kidney disease models: superiority of semiautomated kidney segmentation	27
Lack of renoprotective effects by long-term PCSK9 and SGLT2 inhibition using alirocumab and empagliflozin in obese ZSF1 rats	26
Mechanistic target of rapamycin complex-1 plays a role in inhibiting kidney K + excretion during overnight dietary K +	26
Physical association of NHE3 and SGLT2 mediated by accessory proteins in the renal proximal tubule	25
First Author Highlights	24
Transcriptomics of SGLT2-positive early proximal tubule segments in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism	24
β2-Adrenergic receptor agonists: a new treatment for diabetic kidney disease?	24
A key role of AT1a receptors and Na+/H+ exchanger 3 in the proximal tubules in angiotensin II-induced and two-kidney, one-clip Goldblatt hypertension	23
Perspective on G protein-coupled receptors in renal physiology	23
Optogenetic urothelial cell stimulation induces bladder contractions and pelvic nerve afferent firing	23

Defining protein expression in the kidney at large scale: from antibody validation to cytometry analysis	23
Methylseq, single-nuclei RNAseq, and discovery proteomics identify pathways associated with nephron-deficit CKD in the HSRA rat model	22
Tubular dysfunction impairs renal excretion of pseudouridine in diabetic kidney disease	22
Phosphorylation of aquaporin-2 at serine 269 in urinary extracellular vesicles reflects renal vasopressin activity in rats	21
A combination of β-hydroxybutyrate and citrate ameliorates disease progression in a rat model of polycystic kidney disease	21
Redox regulation in diabetic kidney disease	21
SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy	21
Polygenic genetic variation affecting antibody formation underlies hypertensive renal injury in the stroke-prone spontaneously hypertensive rat	21
Pax inhibition: stressing proximal tubule for successful repair	20
Activation of branched chain amino acid catabolism protects against nephrotoxic acute kidney injury	20
Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury	20
Hyperphosphatemia and zinc deficiency in chronic kidney disease: unpacking their interconnected roles and nutritional implications	19
The nephronophthisis protein GLIS2 / NPHP7 is required for the DNA damage response in kidney tubular epith	19
A brief history of the cortical thick ascending limb: a systems-biology perspective	19
First Author Highlights	18
Epoxyeicosatrienoic acid administration or soluble epoxide hydrolase inhibition attenuates renal fibrogenesis in obstructive nephropathy	18
Editorial Board	18
Novel insight on physiological regulation of the Cl−/HCO3− exchanger pendrin	17
Protein phosphatase 2A subunit B55 alpha is required for angiotensin type 2 receptor elicited natriuresis	17
Valosin-containing protein in ciliary morphology: a novel target in ADPKD	17
Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase	17
Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age	17
Ubiquitination of NKCC2 by the cullin-RING E3 ubiquitin ligase family in the thick ascending limb of the loop of Henle	16
Race and sex differences in pressor response to laboratory stressors in patients with chronic kidney disease	16
Smartwatches in the digital health ecosystem for health monitoring in patients with chronic kidney disease and kidney failure: opportunities and challenges	16
Investigating FSGS-like injury in zebrafish larvae by nifurpirinol: efficacy and molecular insight	16
Metabolomic profiling reveals muscle metabolic changes following iliac arteriovenous fistula creation in mice	16
Kir7.1 knockdown and inhibition alter renal electrolyte handling but not the development of hypertension in Dahl salt-sensitive rats	16
Prolonged unilateral renal ischemia-reperfusion as a model for acute to chronic kidney injury in female mice	16
Influence of proteolytic cleavage of ENaC’s γ subunit upon Na+ and K+ handling	16
A-Intercalated Cell Dysfunction Disrupts Renal Epithelial-Immune Balance and Impairs Host Defense During UTI	16
Cilia-deficient renal tubule cells are primed for injury with mitochondrial defects and aberrant tryptophan metabolism	16
Delayed graft function post renal transplantation: a review on animal models and therapeutics	16
Impaired nitric oxide mechanisms underlying lower urinary tract dysfunction in aging rats	16
Macrophage angiotensin AT2 receptor activation is protective against early phases of LPS-induced acute kidney injury	16
Commensal microbiota regulate aldosterone	16
First Author Spotlight	15
Characterization of FAM114A1: a novel podocyte cytoskeleton-associated protein upregulated in glomerular injury	15
High dietary K+ intake inhibits proximal tubule transport	15
Inducible Avp knockout mouse line	15
Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats	15
Recent advances in understanding the kidney circadian clock mechanism	15
First Author Spotlight	14
A novel functional role for the classic CNS neurotransmitters, GABA, glycine, and glutamate, in the kidney: potent and opposing regulators of the renal vasculature	14
Sex differences in dietary sodium evoked NCC regulation and blood pressure in male and female Sprague-Dawley, Dahl salt-resistant, and Dahl salt-sensitive rats	14
Mapping single-nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging	14
Downloadable Tool for Modeling of Salt, Urea and Water Transport in a Renal Tubule Segment: Application to the DCT	14
Revisiting voltage-coupled H+ secretion in the collecting duct	14
Inducible deletion of the prostaglandin EP3 receptor in kidney tubules of male and female mice has no major effect on water homeostasis	14
The kidney in health and disease in 2022: Gaps in and opportunities for new knowledge	14

Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension	14
Sex-disaggregated analysis of acute kidney injury in hospitalized children with sickle cell anemia in Uganda	14
Impaired hemodynamic renal reserve response following recovery from established acute kidney injury and improvement by hydrodynamic isotonic fluid delivery	13
Citrate modulates calciprotein particle formation and composition	13
Kidney transplant injury associated with brain death is mediated by TNFα, independently of renal innervation	13
Peak oxygen consumption is positively associated with estimates of oxygen extraction and microvascular blood volume in veterans with chronic kidney disease	13
First Author Highlights	13
Sex differences in the renal T cell profile in DOCA-salt hypertension are independent of MR activation and increases in blood pressure	13
Intersecting transcriptomic landscapes of hypertension and kidney function in African American women	13
5-Hydroxytryptamine 1F receptor loss reduces renal vasculature and prevents lasmiditan-induced recovery following moderate-severe acute kidney injury in mice	13
TNIK depletion induces inflammation and apoptosis in injured renal proximal tubule epithelial cells	13
Ad libitum drinking does not mitigate acute kidney injury risk nor elevations in markers of oxidative stress and inflammation during simulated occupational heat stress	13
Pendrin regulation is prioritized by anion in high-potassium diets	13
Editorial Board	12
Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress	12
JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice	12
Kir4.1/Kir5.1 of distal convoluted tubule is required for short-term angiotensin-II-induced stimulation of Na-Cl cotransporter	12
Injury in nonaged podocytes as an accelerator of glomerular aging	12
Cystinosin-deficient rats recapitulate the phenotype of nephropathic cystinosis	12
Exogenous pericyte delivery protects the mouse kidney from chronic ischemic injury	12
Practical notes on popular statistical tests in renal physiology	12
The impact of maternal obesity on polycystic kidney disease progression in a mouse model	12
Prevention of hypertension-induced renal vascular dysfunction through a p66Shc-targeted mechanism	12
Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort	12
Protective effects of fermentable dietary fiber and propionate in Dahl salt-sensitive hypertension and renal damage	12
Amiloride lowers plasma TNF and interleukin-6 but not interleukin-17A in patients with hypertension and type 2 diabetes	12
Sex differences in renal acid-base regulation	12
Pharmacologic disruption of HuR-RNA interactions prevents maladaptive tubular repair and AKI-to-CKD progression	11
Furin-mediated modification is required for epithelial sodium channel-activating activity of soluble (pro)renin receptor in cultured collecting duct cells	11
Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia-reperfusion injury in a sex-dependent manner	11
Chronic kidney disease amplifies severe kidney injury and mortality in a mouse model of skin arsenical exposure	11
First Author Highlights	11
A brief harvesting-freezing delay significantly alters the kidney metabolome and leads to false positive and negative results	11
CRB2 depletion induces YAP signaling and disrupts mechanosensing in podocytes	11
Bayesian mapping of protein kinases to vasopressin-regulated phosphorylation sites in renal collecting duct	11
Male Akita mice develop signs of bladder underactivity independent of NLRP3 as a result of a decrease in neurotransmitter release from efferent neurons	10
The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in the human kidney	10
Vascular transcriptional and metabolic changes precede progressive intrarenal microvascular rarefaction in autosomal dominant polycystic kidney disease	10
Exogenous uromodulin and tubular responses in a model of oxalate-induced kidney injury	10
First Author Highlights	10
Flow-dependent transport processes 2024: filtration, absorption, secretion	10
Pretreatment with a novel Toll-like receptor 4 agonist attenuates renal ischemia-reperfusion injury	10
HMGB1 drives T-cell activation in hypertensive males and females	10
Loss of transcription factor ATOH8 activates TGF-β signaling and exacerbates glomerulosclerosis in podocytes	10
Mechanisms of anti-VEGF therapy-induced kidney injury: current insights and future perspectives in combination with immune checkpoint inhibitors	10
Transcription factor HNF1β controls a transcriptional network regulating kidney cell structure and tight junction integrity	10
Promises and challenges of miRNA therapeutics	10
HIF-mediated regulation of glutathione-specific γ-glutamyl cyclotransferase 1 contributes to tubular cell death in renal ischemia-reperfusion injury	10
Maresin 1 modulates renal and cardiac lipid profiles in hypertensive rats	10
Altered renal vascular patterning reduces ischemic kidney injury and limits age-associated vascular loss	10
Mitochondrial dysfunction in the pathophysiology of renal diseases	10
Macrophages and TGFB signaling regulate fibrosis in the Escherichia coli -infected mouse prostate	10
Nitrite protects against cardiac surgery-associated acute kidney injury via inflammation suppression: insights from a rat cardiopulmonary bypass model	9
Nicotinamide ameliorates podocyte injury and albuminuria in adriamycin-induced nephropathy	9
β2-Adrenergic receptor agonists as a treatment for diabetic kidney disease	9
The nonsteroidal MR antagonist finerenone reverses Western diet-induced kidney disease by regulating mitochondrial and lipid metabolism and inflammation	9
Adverse functions of neutrophils are regulated by neutrophilic angiotensin-converting enzyme in immune complex-mediated crescentic glomerulonephritis	9
Faster bladder filling in rats reduces detrusor overactivity but worsens (i.e., decreases) bladder compliance	9
How does the kidney conserve Na + in a salt-scarce environment?	9
Predicting sex differences in the effects of diuretics in renal epithelial transport during angiotensin II-induced hypertension	9
Renal tubular (pro)renin receptor deletion exacerbates kidney injury in db/db mice	9
First Author Highlights	9
Measuring nephron number in the healthy and diabetic rat kidney in vivo using MRI without contrast agents	9
Chronic circadian stress impairs blood pressure and sodium homeostasis in a diet- and sex-specific manner	9
Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program	9
ΔNP63 regulates epithelial stratification and differentiation in the murine ureter	9
Kidney functional reserve helps early detection of subclinical chronic kidney disease	9
Identification of cell division cycle protein 20 in various forms of acute and chronic kidney injury in mice	9
Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury	9
Postoperative acute kidney injury after volatile or intravenous anesthesia: a meta-analysis	9
Creatinine clearance is maintained in a range of wet-bulb globe temperatures and work-rest ratios during simulated occupational heat stress	9
The miR-143/145 cluster induced by TGF-β1 suppresses Wilms’ tumor 1 expression in cultured human podocytes	9
Novel method for kinetic analysis applied to transport by the uniporter OCT2	9
Inhibition of mTORC2 promotes natriuresis in Dahl salt-sensitive rats via the decrease of NCC and ENaC activity	9
Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation	9
First Author Highlights	9
Excessive protein uptake by endocytic receptors causes elevated proliferation and senescence in proximal tubules primarily in outer medulla of proteinuric mice	8
2024 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal Section	8
Corrigendum for Martínez-Rojas et al., volume 323, 2022, p. F425–F434	8
First Author Highlights	8

Tacrolimus induces fibroblast-to-myofibroblast transition via a TGF-β-dependent mechanism to contribute to renal fibrosis	8
Activation of farnesoid X receptor inhibits TMEM16A-mediated chloride secretion in renal collecting duct cells and retards renal cyst progression	8
The degree of aortic occlusion in the setting of trauma alters the extent of acute kidney injury associated with mitochondrial preservation	8
Endothelin-1 signaling in the kidney: recent advances and remaining gaps	8
Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice	8
Corrigendum for Beenken et al., volume 327, 2024, p. F775–F787	8
Longitudinal intravital microscopy of the mouse kidney: inflammatory responses to abdominal imaging windows	8
Diffusion tensor MRI is sensitive to fibrotic injury in a mouse model of oxalate-induced chronic kidney disease	8
The response to kidney injury is epigenetically regulated through the activation of bivalent genes	8
Editorial Board	8
Metabolomic profiling to identify early urinary biomarkers and metabolic pathway alterations in autosomal dominant polycystic kidney disease	8
Corrigendum for McKinzie et al., volume 326, 2024, p. F644–F660	8
Assays to enhance metabolic phenotyping in the kidney	8
Role of protease-activated receptor 4 in mouse models of acute and chronic kidney injury	8
The knock-out of paracingulin attenuates hypertension through modulation of kidney ion transport	7
Western diet exacerbates a murine model of Balkan nephropathy	7
First Author Highlights	7
Sex differences in circadian regulation of kidney function of the mouse	7
SGLT2 inhibitors: not every drug has the same effect	7
The role of Gata3 in renin cell identity	7
Endothelial dysfunction in the aging kidney	7
KCC3 is not required for the distal convoluted tubule response to reduced dietary potassium intake	7
PLVAP: the new villain in glomerular endothelial cell injury	7
Chronic central nervous system leptin administration attenuates kidney dysfunction and injury in a model of ischemia/reperfusion-induced acute kidney injury	7
Cullin 3 mutant causing familial hyperkalemic hypertension lacks normal activity in the kidney	7
Pathways and parameters of sacral neuromodulation in rats	7
The unique structural and functional characteristics of glomerular endothelial cell fenestrations and their potential as a therapeutic target in kidney disease	7
Renal ischemia-reperfusion injury triggers proximal tubular apoptosis and NHE3 dysfunction via p38MAPK/ezrin signaling pathway	7
Single-cell RNA sequencing and spatial transcriptomics reveal unique subpopulations of infiltrating macrophages and dendritic cells following AKI	7
The evolving concepts of KS-WNK1 effect on NCC activity	7
Transition from acute kidney injury to chronic kidney disease: mechanisms, models, and biomarkers	7
A comparative modeling study of the mitochondrial function of the proximal tubule and thick ascending limb cells in the rat kidney	7
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake	7
Epigenetic regulation of nephrogenesis: from Waddington’s landscape to adult disease	7
Spleen tyrosine kinase signaling in myeloid cells promotes macrophage infiltration, glomerulosclerosis, and interstitial fibrosis in diabetic kidney disease	6
Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na+ and K+	6
Circadian gene expression in mouse renal proximal tubule	6
Guidelines on antibody use in physiology research	6
Podocyte injury at young age causes premature senescence and worsens glomerular aging	6
Oxysterol-binding protein-like 7 deficiency leads to ER stress-mediated apoptosis in podocytes and proteinuria	6
Proteinuria remission profiles in obesity-related kidney disease after bariatric surgery	6
Kidney organoid models of polycystic kidney disease: challenges and future directions	6
Intestinal barrier function declines during polycystic kidney disease progression	6
The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu)	6
Functional NADPH oxidase 2 in T cells amplifies salt-sensitive hypertension and associated renal damage	6
Anatomic and functional evidence for renal autonomic innervation in normotensive and hypertensive rats	6
Editorial Board	6
Early-life exposures and long-term health: adverse gestational environments and the programming of offspring renal and vascular disease	6
Generation of Atp6v1g3-Cre mice for investigation of intercalated cells and the collecting duct	6
Sex-specific modulation of renal epigenetic and injury markers in aging kidney	6
The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials	6
Renal calcium and magnesium handling during pregnancy: modeling and analysis	6
Expression and distribution of MUC1 in the developing and adult kidney	6
Endothelin receptor B is required for the blood pressure-lowering effect of G protein-coupled estrogen receptor 1 in ovariectomized rats	6
Hepatic and proximal tubule angiotensinogen play distinct roles in kidney dysfunction, glomerular and tubular injury, and fibrosis progression	6
First Author Highlights	6
Population-level circadian rhythm of eGFR and the effect of chronodisruption	6
Lung cancer-kidney cross talk induces kidney injury, interstitial fibrosis, and enhances cisplatin-induced nephrotoxicity	6
Tips on navigating the first year of graduate school for individuals from historically excluded backgrounds	6
The organelle-tethering protein PDZD8 regulates endolysosomal maturation and TLR9-NF-κB signaling in cisplatin-induced acute kidney injury	6
Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect	6
Effect of sex chromosome complement versus gonadal hormones on abundance of renal transporters	6
Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes	6
Role of coagulation in persistent renal ischemia following reperfusion in an animal model	6
Loss of Fn14 reduces cisplatin-induced maladaptive inflammatory and fibrotic gene expression and limits downstream tubular damage	6
Electron paramagnetic resonance imaging to detect acute kidney injury	5
Impact of bedding on Dahl salt-sensitive hypertension and renal damage	5
Proximal tubule pannexin 1 contributes to mitochondrial dysfunction and cell death during acute kidney injury	5
Podocytes are lost from glomeruli before completing apoptosis	5
Therapeutic α-1-microglobulin ameliorates kidney ischemia-reperfusion injury	5
Dapagliflozin ameliorates high-fat diet–induced, megalin-mediated autolysosomal dysfunction in proximal tubules via suppression of megalin-dependent endocytosis	5
The hypoxia-inducible factor-α prolyl hydroxylase inhibitor FG4592 ameliorates renal fibrosis by inducing the H3K9 demethylase JMJD1A	5
Kidney functional reserve and damage biomarkers in subclinical chronic kidney disease and acute kidney injury	5
First Author Highlights	5
Modulation of blood pressure by dietary potassium and sodium: sex differences and modeling analysis	5
Wilms’ tumor gene 1: lessons from the interface between kidney development and cancer	5
Role of the SLC22A17/lipocalin-2 receptor in renal endocytosis of proteins/metalloproteins: a focus on iron- and cadmium-binding proteins	5
The FSGS protein actinin-4 interacts with NKCC2 to regulate thick ascending limb NaCl reabsorption	5
First Author Highlights	5
Nicorandil protects podocytes via modulation of antioxidative capacity in acute puromycin aminonucleoside-induced nephrosis in rats	5
Renal G protein-coupled estrogen receptor 1 regulates the epithelial sodium channel promoting natriuresis to a greater extent in females	5
Fibroblast histone deacetylase-1 promotes kidney interstitial fibrosis following ischemia-reperfusion injury	5
Kidney kallikrein-1 contributes to cleavage of γ-ENaC in vivo	5
Chronic environmental hypoxia attenuates innate immunity activation and renal injury in two CKD models	5
Autophagy and mitophagy: physiological implications in kidney inflammation and diseases	5
Raising serum uric acid with a uricase inhibitor worsens PKD in rat and mouse models	5
Persistence and expansion of hypoxia detected by pimonidazole adduct immunostaining during progression of diabetic nephropathy in diabetic mice	5
Exercise for patients with chronic kidney disease: from cells to systems to function	5
Diabetes causes NLRP3-dependent barrier dysfunction in mice with detrusor overactivity but not underactivity	5
Induction of plasmalemmal vesicle-associated protein exacerbates glomerular endothelial injury in thrombotic microangiopathy	5
Renal macro- and microcirculatory perturbations in acute kidney injury and chronic kidney disease associated with heart failure and cardiac surgery	5
The transcription factor Tcf21 is necessary for adoption of cell fates by Foxd1 + stromal progenitors during kidney develo	5
Myeloid-specific ferritin light chain deletion does not exacerbate sepsis-associated AKI	5
The endocytic adaptor ARH facilitates potassium conservation by regulating ROMK and BK	5
Ribosomal s6 kinase is a mediator of aquaporin-2 S256 phosphorylation and membrane accumulation after EGFR inhibition with erlotinib	5