American Journal of Physiology-Renal Physiology

Article	Citations
First Author Highlights	54
Accuracy and processing time of kidney volume measurement methods in rodents polycystic kidney disease models: superiority of semiautomated kidney segmentation	50
First Author Highlights	49
First Author Highlights	45
“Idiopathic” minimal change nephrotic syndrome: a podocyte mystery nears the end	45
Exercise sensitizes the pressure diuresis response: shifting immune landscapes may underlie renal adaptations	43
Role of the CDKL1-SOX11 signaling axis in acute kidney injury	42
Distinct developmental reprogramming footprint of macrophages during acute kidney injury across species	39
Physical association of NHE3 and SGLT2 mediated by accessory proteins in the renal proximal tubule	36
Corrigendum for Jang et al., volume 326, 2024, p. F69	35
Transcriptomics of SGLT2-positive early proximal tubule segments in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism	33
Chronic infusion of the tryptophan metabolite kynurenine increases mean arterial pressure in male Sprague-Dawley rats	32
Lack of renoprotective effects by long-term PCSK9 and SGLT2 inhibition using alirocumab and empagliflozin in obese ZSF1 rats	30
Interleukin-6 blockade reduces salt-induced cardiac inflammation and fibrosis in subtotal nephrectomized mice	30
Perinatal asphyxia leads to acute kidney damage and increased renal susceptibility in adulthood	29
Expression of leptin receptor in renal tubules is sparse but implicated in leptin-dependent kidney gene expression and function	28
Stimulation of basolateral calcium-sensing receptor inhibits Kir4.1/Kir5.1 in the mouse distal convoluted tubule	27
Small hairpin inhibitory RNA delivery in the metanephric organ culture identifies long noncoding RNA Pvt1 as a modulator of cyst growth	27
C-terminal fragment of fibroblast growth factor 23 improves heart function in murine models of high intact fibroblast growth factor 23	26
First Author Highlights	25
Polygenic genetic variation affecting antibody formation underlies hypertensive renal injury in the stroke-prone spontaneously hypertensive rat	25
β2-Adrenergic receptor agonists: a new treatment for diabetic kidney disease?	23
Defining protein expression in the kidney at large scale: from antibody validation to cytometry analysis	23
A key role of AT1a receptors and Na+/H+ exchanger 3 in the proximal tubules in angiotensin II-induced and two-kidney, one-clip Goldblatt hypertension	22
Perspective on G protein-coupled receptors in renal physiology	22

Methylseq, single-nuclei RNAseq, and discovery proteomics identify pathways associated with nephron-deficit CKD in the HSRA rat model	22
Pax inhibition: stressing proximal tubule for successful repair	22
Optogenetic urothelial cell stimulation induces bladder contractions and pelvic nerve afferent firing	21
The nephronophthisis protein GLIS2 / NPHP7 is required for the DNA damage response in kidney tubular epith	21
A brief history of the cortical thick ascending limb: a systems-biology perspective	20
Redox regulation in diabetic kidney disease	20
Tubular dysfunction impairs renal excretion of pseudouridine in diabetic kidney disease	20
A combination of β-hydroxybutyrate and citrate ameliorates disease progression in a rat model of polycystic kidney disease	20
Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury	19
Activation of branched chain amino acid catabolism protects against nephrotoxic acute kidney injury	19
Hyperphosphatemia and zinc deficiency in chronic kidney disease: unpacking their interconnected roles and nutritional implications	19
SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy	19
First Author Highlights	18
Race and sex differences in pressor response to laboratory stressors in patients with chronic kidney disease	18
Angiotensin in the acute and chronic responses to unilateral nephrectomy	18
Epoxyeicosatrienoic acid administration or soluble epoxide hydrolase inhibition attenuates renal fibrogenesis in obstructive nephropathy	18
Kir7.1 knockdown and inhibition alter renal electrolyte handling but not the development of hypertension in Dahl salt-sensitive rats	17
Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age	17
Editorial Board	17
Novel insight on physiological regulation of the Cl−/HCO3− exchanger pendrin	16
Protein phosphatase 2A subunit B55 alpha is required for angiotensin type 2 receptor elicited natriuresis	16
Cilia-deficient renal tubule cells are primed for injury with mitochondrial defects and aberrant tryptophan metabolism	16
Ubiquitination of NKCC2 by the cullin-RING E3 ubiquitin ligase family in the thick ascending limb of the loop of Henle	16
Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase	16
Delayed graft function post renal transplantation: a review on animal models and therapeutics	16
Valosin-containing protein in ciliary morphology: a novel target in ADPKD	16
Prolonged unilateral renal ischemia-reperfusion as a model for acute to chronic kidney injury in female mice	15
High dietary K+ intake inhibits proximal tubule transport	15
Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats	15
Commensal microbiota regulate aldosterone	15
Inhibition of hypoxia-inducible factor-prolyl hydroxylation protects from cyclophosphamide-induced bladder injury and urinary dysfunction	15
Impaired nitric oxide mechanisms underlying lower urinary tract dysfunction in aging rats	15
Recent advances in understanding the kidney circadian clock mechanism	15
Investigating FSGS-like injury in zebrafish larvae by nifurpirinol: efficacy and molecular insight	15
Characterization of FAM114A1: a novel podocyte cytoskeleton-associated protein upregulated in glomerular injury	15
Metabolomic profiling reveals muscle metabolic changes following iliac arteriovenous fistula creation in mice	15
Inducible Avp knockout mouse line	15
Comparison of the surgical resection and infarct 5/6 nephrectomy rat models of chronic kidney disease	14
Downloadable Tool for Modeling of Salt, Urea and Water Transport in a Renal Tubule Segment: Application to the DCT	14
Influence of proteolytic cleavage of ENaC’s γ subunit upon Na+ and K+ handling	14
First Author Spotlight	14
The kidney in health and disease in 2022: Gaps in and opportunities for new knowledge	14
Macrophage angiotensin AT2 receptor activation is protective against early phases of LPS-induced acute kidney injury	14
First Author Spotlight	14
Mapping single-nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging	14
Peak Oxygen Consumption is Positively Associated with Estimates of Oxygen Extraction and Microvascular Blood Volume in Veterans with Chronic Kidney Disease	13
Pendrin regulation is prioritized by anion in high-potassium diets	13
Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension	13
Kir4.1/Kir5.1 of distal convoluted tubule is required for short-term angiotensin-II-induced stimulation of Na-Cl cotransporter	13
Sex-disaggregated analysis of acute kidney injury in hospitalized children with sickle cell anemia in Uganda	13

Ad libitum drinking does not mitigate acute kidney injury risk nor elevations in markers of oxidative stress and inflammation during simulated occupational heat stress	13
Revisiting voltage-coupled H+ secretion in the collecting duct	13
A novel functional role for the classic CNS neurotransmitters, GABA, glycine, and glutamate, in the kidney: potent and opposing regulators of the renal vasculature	13
The impact of maternal obesity on polycystic kidney disease progression in a mouse model	13
Intersecting transcriptomic landscapes of hypertension and kidney function in African American women	13
TNIK depletion induces inflammation and apoptosis in injured renal proximal tubule epithelial cells	13
Kidney transplant injury associated with brain death is mediated by TNFα, independently of renal innervation	13
Sex differences in dietary sodium evoked NCC regulation and blood pressure in male and female Sprague-Dawley, Dahl salt-resistant, and Dahl salt-sensitive rats	12
A brief harvesting-freezing delay significantly alters the kidney metabolome and leads to false positive and negative results	12
5-Hydroxytryptamine 1F receptor loss reduces renal vasculature and prevents lasmiditan-induced recovery following moderate-severe acute kidney injury in mice	12
Practical notes on popular statistical tests in renal physiology	12
Physiology assays in human kidney organoids	12
Inducible deletion of the prostaglandin EP3 receptor in kidney tubules of male and female mice has no major effect on water homeostasis	12
Prevention of hypertension-induced renal vascular dysfunction through a p66Shc-targeted mechanism	12
Citrate modulates calciprotein particle formation and composition	12
Injury in nonaged podocytes as an accelerator of glomerular aging	12
Sex differences in renal acid-base regulation	12
Impaired hemodynamic renal reserve response following recovery from established acute kidney injury and improvement by hydrodynamic isotonic fluid delivery	12
Editorial Board	12
First Author Highlights	12
Regulation of kidney mitochondrial function by caloric restriction	12
Cystinosin-deficient rats recapitulate the phenotype of nephropathic cystinosis	11
Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia-reperfusion injury in a sex-dependent manner	11
Protective effects of fermentable dietary fiber and propionate in Dahl salt-sensitive hypertension and renal damage	11
Furin-mediated modification is required for epithelial sodium channel-activating activity of soluble (pro)renin receptor in cultured collecting duct cells	11
Bayesian mapping of protein kinases to vasopressin-regulated phosphorylation sites in renal collecting duct	11
Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress	11
Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort	11
Influence of carnosine and carnosinase-1 on diabetes-induced afferent arteriole vasodilation: implications for glomerular hemodynamics	11
Amiloride lowers plasma TNF and interleukin-6 but not interleukin-17A in patients with hypertension and type 2 diabetes	11
The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in the human kidney	11
Exogenous pericyte delivery protects the mouse kidney from chronic ischemic injury	11
Chronic kidney disease amplifies severe kidney injury and mortality in a mouse model of skin arsenical exposure	11
CRB2 depletion induces YAP signaling and disrupts mechanosensing in podocytes	11
First Author Highlights	11
JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice	11
Mechanisms of anti-VEGF therapy-induced kidney injury: current insights and future perspectives in combination with immune checkpoint inhibitors	10
HMGB1 drives T-cell activation in hypertensive males and females	10
Pretreatment with a novel Toll-like receptor 4 agonist attenuates renal ischemia-reperfusion injury	10
Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury	10
First Author Highlights	10
Male Akita mice develop signs of bladder underactivity independent of NLRP3 as a result of a decrease in neurotransmitter release from efferent neurons	10
Vascular transcriptional and metabolic changes precede progressive intrarenal microvascular rarefaction in autosomal dominant polycystic kidney disease	10
Loss of transcription factor ATOH8 activates TGF-β signaling and exacerbates glomerulosclerosis in podocytes	10
Mitochondrial dysfunction in the pathophysiology of renal diseases	10
Altered renal vascular patterning reduces ischemic kidney injury and limits age-associated vascular loss	10
Promises and challenges of miRNA therapeutics	10
Maresin 1 modulates renal and cardiac lipid profiles in hypertensive rats	10
Exogenous uromodulin and tubular responses in a model of oxalate-induced kidney injury	10
HIF-mediated regulation of glutathione-specific gamma-glutamyl cyclotransferase 1 contributes to tubular cell death in renal ischemia–reperfusion	10
Adverse functions of neutrophils are regulated by neutrophilic angiotensin-converting enzyme in immune complex-mediated crescentic glomerulonephritis	10
Measuring nephron number in the healthy and diabetic rat kidney in vivo using MRI without contrast agents	10
Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program	9
Inhibition of mTORC2 promotes natriuresis in Dahl salt-sensitive rats via the decrease of NCC and ENaC activity	9
Chronic circadian stress impairs blood pressure and sodium homeostasis in a diet- and sex-specific manner	9
First Author Spotlight	9
Kidney functional reserve helps early detection of subclinical chronic kidney disease	9
Novel method for kinetic analysis applied to transport by the uniporter OCT2	9
β2-Adrenergic receptor agonists as a treatment for diabetic kidney disease	9
Nicotinamide ameliorates podocyte injury and albuminuria in adriamycin-induced nephropathy	9
Postoperative acute kidney injury after volatile or intravenous anesthesia: a meta-analysis	9
The miR-143/145 cluster induced by TGF-β1 suppresses Wilms’ tumor 1 expression in cultured human podocytes	9
Longitudinal intravital microscopy of the mouse kidney: inflammatory responses to abdominal imaging windows	9
Assays to enhance metabolic phenotyping in the kidney	9
The nonsteroidal MR antagonist finerenone reverses Western diet-induced kidney disease by regulating mitochondrial and lipid metabolism and inflammation	9
Transcription factor HNF1β controls a transcriptional network regulating kidney cell structure and tight junction integrity	9
Creatinine clearance is maintained in a range of wet-bulb globe temperatures and work-rest ratios during simulated occupational heat stress	9
Macrophages and TGFB signaling regulate fibrosis in the Escherichia coli -infected mouse prostate	9
Renal tubular (pro)renin receptor deletion exacerbates kidney injury in db/db mice	9
Tacrolimus induces fibroblast-to-myofibroblast transition via a TGF-β-dependent mechanism to contribute to renal fibrosis	9
Flow-dependent transport processes 2024: filtration, absorption, secretion	9
Faster bladder filling in rats reduces detrusor overactivity but worsens (i.e., decreases) bladder compliance	8
Role of protease-activated receptor 4 in mouse models of acute and chronic kidney injury	8
First Author Highlights	8
How does the kidney conserve Na + in a salt-scarce environment?	8
2024 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal Section	8
First Author Highlights	8
The response to kidney injury is epigenetically regulated through the activation of bivalent genes	8
Activation of farnesoid X receptor inhibits TMEM16A-mediated chloride secretion in renal collecting duct cells and retards renal cyst progression	8
Predicting sex differences in the effects of diuretics in renal epithelial transport during angiotensin II-induced hypertension	8

Endothelin-1 signaling in the kidney: recent advances and remaining gaps	8
KCC3 is not required for the distal convoluted tubule response to reduced dietary potassium intake	8
Editorial Board	8
The degree of aortic occlusion in the setting of trauma alters the extent of acute kidney injury associated with mitochondrial preservation	8
Identification of cell division cycle protein 20 in various forms of acute and chronic kidney injury in mice	8
Diffusion tensor MRI is sensitive to fibrotic injury in a mouse model of oxalate-induced chronic kidney disease	8
Western diet exacerbates a murine model of Balkan nephropathy	8
Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation	8
Metabolomic profiling to identify early urinary biomarkers and metabolic pathway alterations in autosomal dominant polycystic kidney disease	7
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy	7
Sex differences in circadian regulation of kidney function of the mouse	7
Endothelial dysfunction in the aging kidney	7
Chronic central nervous system leptin administration attenuates kidney dysfunction and injury in a model of ischemia/reperfusion-induced acute kidney injury	7
Corrigendum for Martínez-Rojas et al., volume 323, 2022, p. F425–F434	7
Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice	7
Pathways and parameters of sacral neuromodulation in rats	7
The knock-out of paracingulin attenuates hypertension through modulation of kidney ion transport	7
The evolving concepts of KS-WNK1 effect on NCC activity	7
A comparative modeling study of the mitochondrial function of the proximal tubule and thick ascending limb cells in the rat kidney	7
Myo-inositol oxygenase in cadmium-induced kidney injury	7
Corrigendum for Beenken et al., volume 327, 2024, p. F775–F787	7
Corrigendum for McKinzie et al., volume 326, 2024, p. F644–F660	7
The role of Gata3 in renin cell identity	7
Single-cell RNA sequencing and spatial transcriptomics reveal unique subpopulations of infiltrating macrophages and dendritic cells following AKI	7
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake	7
Renal ischemia-reperfusion injury triggers proximal tubular apoptosis and NHE3 dysfunction via p38MAPK/ezrin signaling pathway	7
Cullin 3 mutant causing familial hyperkalemic hypertension lacks normal activity in the kidney	7
SGLT2 inhibitors: not every drug has the same effect	7
Expression and distribution of MUC1 in the developing and adult kidney	6
Circadian gene expression in mouse renal proximal tubule	6
Hepatic and proximal tubule angiotensinogen play distinct roles in kidney dysfunction, glomerular and tubular injury, and fibrosis progression	6
Persistence and expansion of hypoxia detected by pimonidazole adduct immunostaining during progression of diabetic nephropathy in diabetic mice	6
The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials	6
Tips on navigating the first year of graduate school for individuals from historically excluded backgrounds	6
Population-level circadian rhythm of eGFR and the effect of chronodisruption	6
Podocyte injury at young age causes premature senescence and worsens glomerular aging	6
Editorial Board	6
Intestinal barrier function declines during polycystic kidney disease progression	6
Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes	6
Transition from acute kidney injury to chronic kidney disease: mechanisms, models, and biomarkers	6
Spleen tyrosine kinase signaling in myeloid cells promotes macrophage infiltration, glomerulosclerosis, and interstitial fibrosis in diabetic kidney disease	6
Effect of sex chromosome complement versus gonadal hormones on abundance of renal transporters	6
Raising serum uric acid with a uricase inhibitor worsens PKD in rat and mouse models	6
Early-life exposures and long-term health: adverse gestational environments and the programming of offspring renal and vascular disease	6
Sex-specific modulation of renal epigenetic and injury markers in aging kidney	6
Kidney stone formation in a novel murine model of polycystic kidney disease	6
Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na+ and K+	6
Functional NADPH oxidase 2 in T cells amplifies salt-sensitive hypertension and associated renal damage	6
The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu)	6
PLVAP: the new villain in glomerular endothelial cell injury	6
The unique structural and functional characteristics of glomerular endothelial cell fenestrations and their potential as a therapeutic target in kidney disease	6
First Author Highlights	6
Renal calcium and magnesium handling during pregnancy: modeling and analysis	6
Lung cancer-kidney cross talk induces kidney injury, interstitial fibrosis, and enhances cisplatin-induced nephrotoxicity	6
Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect	6
The organelle-tethering protein PDZD8 regulates endolysosomal maturation and TLR9-NF-κB signaling in cisplatin-induced acute kidney injury	6
Kidney organoid models of polycystic kidney disease: challenges and future directions	6
Endothelin receptor B is required for the blood pressure-lowering effect of G protein-coupled estrogen receptor 1 in ovariectomized rats	6
Anatomic and functional evidence for renal autonomic innervation in normotensive and hypertensive rats	6
Role of coagulation in persistent renal ischemia following reperfusion in an animal model	6
Amiloride evokes significant natriuresis and weight loss in kidney transplant recipients with and without albuminuria	5
Nicorandil protects podocytes via modulation of antioxidative capacity in acute puromycin aminonucleoside-induced nephrosis in rats	5
First Author Highlights	5
Exercise for patients with chronic kidney disease: from cells to systems to function	5
Kidney kallikrein-1 contributes to cleavage of γ-ENaC in vivo	5
The hypoxia-inducible factor-α prolyl hydroxylase inhibitor FG4592 ameliorates renal fibrosis by inducing the H3K9 demethylase JMJD1A	5
Induction of plasmalemmal vesicle-associated protein exacerbates glomerular endothelial injury in thrombotic microangiopathy	5
The transcription factor Tcf21 is necessary for adoption of cell fates by Foxd1 + stromal progenitors during kidney develo	5
Autophagy and mitophagy: physiological implications in kidney inflammation and diseases	5
Ribosomal s6 kinase is a mediator of aquaporin-2 S256 phosphorylation and membrane accumulation after EGFR inhibition with erlotinib	5
Impact of bedding on Dahl salt-sensitive hypertension and renal damage	5
Modulation of blood pressure by dietary potassium and sodium: sex differences and modeling analysis	5
Proximal tubule pannexin 1 contributes to mitochondrial dysfunction and cell death during acute kidney injury	5
Podocytes are lost from glomeruli before completing apoptosis	5
The FSGS protein actinin-4 interacts with NKCC2 to regulate thick ascending limb NaCl reabsorption	5
Renal macro- and microcirculatory perturbations in acute kidney injury and chronic kidney disease associated with heart failure and cardiac surgery	5
The Michigan O’Brien Kidney Research Center: transforming translational kidney research through systems biology	5
Fibroblast histone deacetylase-1 promotes kidney interstitial fibrosis following ischemia-reperfusion injury	5
Diabetes causes NLRP3-dependent barrier dysfunction in mice with detrusor overactivity but not underactivity	5
First Author Highlights	5
The Janus view: dual roles for hypoxia-inducible factor in renal repair after acute kidney injury	5
Electron paramagnetic resonance imaging to detect acute kidney injury	5
Generation of Atp6v1g3-Cre mice for investigation of intercalated cells and the collecting duct	5
Role of the SLC22A17/lipocalin-2 receptor in renal endocytosis of proteins/metalloproteins: a focus on iron- and cadmium-binding proteins	5
Kidney functional reserve and damage biomarkers in subclinical chronic kidney disease and acute kidney injury	5
When ACE2 turns against the kidney: a paradox unveiled in heme-induced AKI	5
Mitochondria as mediators of systemic inflammation and organ cross talk in acute kidney injury	5
Inhaled silica nanoparticles cause chronic kidney disease in rats	5
Therapeutic α-1-microglobulin ameliorates kidney ischemia-reperfusion injury	5
Renal G protein-coupled estrogen receptor 1 regulates the epithelial sodium channel promoting natriuresis to a greater extent in females	5
Myeloid-specific ferritin light chain deletion does not exacerbate sepsis-associated AKI	5
Wilms’ tumor gene 1: lessons from the interface between kidney development and cancer	5
Angiotensin (1–7) protects against renal ischemia-reperfusion injury via regulating expression of NRF2 and microRNAs in Fisher 344 rats	5
Guidelines on antibody use in physiology research	5
Oxysterol-binding protein-like 7 deficiency leads to ER stress-mediated apoptosis in podocytes and proteinuria	5