American Journal of Physiology-Renal Physiology

Article	Citations
Chronic infusion of the tryptophan metabolite kynurenine increases mean arterial pressure in male Sprague-Dawley rats	56
Role of the CDKL1-SOX11 signaling axis in acute kidney injury	52
Accuracy and processing time of kidney volume measurement methods in rodents polycystic kidney disease models: superiority of semiautomated kidney segmentation	36
Expression of leptin receptor in renal tubules is sparse but implicated in leptin-dependent kidney gene expression and function	35
“Idiopathic” minimal change nephrotic syndrome: a podocyte mystery nears the end	34
Corrigendum for Jang et al., volume 326, 2024, p. F69	34
First Author Highlights	34
First Author Highlights	31
Transcriptomics of SGLT2-positive early proximal tubule segments in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism	31
Perinatal asphyxia leads to acute kidney damage and increased renal susceptibility in adulthood	30
C-terminal fragment of fibroblast growth factor 23 improves heart function in murine models of high intact fibroblast growth factor 23	29
Distinct developmental reprogramming footprint of macrophages during acute kidney injury across species	28
Lack of renoprotective effects by long-term PCSK9 and SGLT2 inhibition using alirocumab and empagliflozin in obese ZSF1 rats	27
Interleukin-6 blockade reduces salt-induced cardiac inflammation and fibrosis in subtotal nephrectomized mice	26
First Author Highlights	25
A mathematical model of the rat kidney. IV. Whole kidney response to hyperkalemia	25
First Author Spotlight	25
Small hairpin inhibitory RNA delivery in the metanephric organ culture identifies long noncoding RNA Pvt1 as a modulator of cyst growth	25
Redox regulation in diabetic kidney disease	24
Activation of branched chain amino acid catabolism protects against nephrotoxic acute kidney injury	24
Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury	23
Pax inhibition: stressing proximal tubule for successful repair	23
A brief history of the cortical thick ascending limb: a systems-biology perspective	22
Polygenic genetic variation affecting antibody formation underlies hypertensive renal injury in the stroke-prone spontaneously hypertensive rat	21
Ultrabright plasmonic fluor nanolabel-enabled detection of a urinary ER stress biomarker in autosomal dominant tubulointerstitial kidney disease	21

Methylseq, single-nuclei RNAseq, and discovery proteomics identify pathways associated with nephron-deficit CKD in the HSRA rat model	21
Porcine models of acute kidney injury	20
Hints for a kidney lactate shuttle and lactomone	20
Tubular dysfunction impairs renal excretion of pseudouridine in diabetic kidney disease	20
Defining protein expression in the kidney at large scale: from antibody validation to cytometry analysis	20
Characterization of a functional V1B vasopressin receptor in the male rat kidney: evidence for cross talk between V1B and V2 receptor signaling pathways	20
β2-Adrenergic receptor agonists: a new treatment for diabetic kidney disease?	20
Perspective on G protein-coupled receptors in renal physiology	19
A combination of β-hydroxybutyrate and citrate ameliorates disease progression in a rat model of polycystic kidney disease	19
Circulating extracellular vesicles of patients with steroid-sensitive nephrotic syndrome have higher RAC1 and induce recapitulation of nephrotic syndrome phenotype in podocytes	19
Optogenetic urothelial cell stimulation induces bladder contractions and pelvic nerve afferent firing	19
Splenocyte transfer from hypertensive donors eliminates premenopausal female protection from ANG II-induced hypertension	18
First Author Highlights	18
Prolonged unilateral renal ischemia-reperfusion as a model for acute to chronic kidney injury in female mice	18
Renal cell markers: lighthouses for managing renal diseases	18
Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age	18
SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy	18
Hyperphosphatemia and zinc deficiency in chronic kidney disease: unpacking their interconnected roles and nutritional implications	18
Cilia-deficient renal tubule cells are primed for injury with mitochondrial defects and aberrant tryptophan metabolism	18
Overview of acute kidney manifestations and management of patients with COVID-19	17
15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction	17
Kidney hemodynamic function in men and postmenopausal women with type 2 diabetes and preserved kidney function	16
Inhibition of hypoxia-inducible factor-prolyl hydroxylation protects from cyclophosphamide-induced bladder injury and urinary dysfunction	16
Ubiquitination of NKCC2 by the cullin-RING E3 ubiquitin ligase family in the thick ascending limb of the loop of Henle	16
Angiotensin in the acute and chronic responses to unilateral nephrectomy	16
Novel insight on physiological regulation of the Cl−/HCO3− exchanger pendrin	16
Dysregulation of the sensory and regulatory pathways controlling cellular iron metabolism in unilateral obstructive nephropathy	16
Kir7.1 knockdown and inhibition alter renal electrolyte handling but not the development of hypertension in Dahl salt-sensitive rats	15
Epoxyeicosatrienoic acid administration or soluble epoxide hydrolase inhibition attenuates renal fibrogenesis in obstructive nephropathy	15
Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats	15
A naturally occurring FXR agonist, alisol B 23-acetate, protects against renal ischemia-reperfusion injury	15
Local and downstream actions of proximal tubule angiotensin II signaling on Na+ transporters in the mouse nephron	15
Macrophage angiotensin AT2 receptor activation is protective against early phases of LPS-induced acute kidney injury	15
Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase	15
Delayed graft function post renal transplantation: a review on animal models and therapeutics	15
Corrigendum for Fu et al., volume 317, 2019, p. F1582–F1592	15
First Author Spotlight	15
Characterization of FAM114A1: a novel podocyte cytoskeleton-associated protein upregulated in glomerular injury	14
Influence of proteolytic cleavage of ENaC’s γ subunit upon Na+ and K+ handling	14
Investigating FSGS-like injury in zebrafish larvae by nifurpirinol: efficacy and molecular insight	14
Commensal microbiota regulate aldosterone	14
High dietary K+ intake inhibits proximal tubule transport	13
Recent advances in understanding the kidney circadian clock mechanism	13
First Author Spotlight	13
High baseline ROMK activity in the mouse late distal convoluted and early connecting tubule probably contributes to aldosterone-independent K+ secretion	13
Impaired nitric oxide mechanisms underlying lower urinary tract dysfunction in aging rats	13
First Author Spotlight	13
Predicting oxygen tension along the ureter	13
Metabolomic profiling reveals muscle metabolic changes following iliac arteriovenous fistula creation in mice	13
Comparison of the surgical resection and infarct 5/6 nephrectomy rat models of chronic kidney disease	13

Mapping single-nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging	12
Revisiting voltage-coupled H+ secretion in the collecting duct	12
Sex-disaggregated analysis of acute kidney injury in hospitalized children with sickle cell anemia in Uganda	12
Angiotensin II-stimulated proximal nephron superoxide production and fructose-induced salt-sensitive hypertension	12
Impaired hemodynamic renal reserve response following recovery from established acute kidney injury and improvement by hydrodynamic isotonic fluid delivery	12
A novel functional role for the classic CNS neurotransmitters, GABA, glycine, and glutamate, in the kidney: potent and opposing regulators of the renal vasculature	12
TNIK depletion induces inflammation and apoptosis in injured renal proximal tubule epithelial cells	12
The kidney in health and disease in 2022: Gaps in and opportunities for new knowledge	12
The impact of maternal obesity on polycystic kidney disease progression in a mouse model	12
Downloadable Tool for Modeling of Salt, Urea and Water Transport in a Renal Tubule Segment: Application to the DCT	12
Injury in nonaged podocytes as an accelerator of glomerular aging	11
Physiology assays in human kidney organoids	11
Sex differences in dietary sodium evoked NCC regulation and blood pressure in male and female Sprague-Dawley, Dahl salt-resistant, and Dahl salt-sensitive rats	11
Regulation of kidney mitochondrial function by caloric restriction	11
Sacubitril/valsartan treatment has differential effects in modulating diabetic kidney disease in db/db mice and KKAy mice compared with valsartan treatment	11
Inducible deletion of the prostaglandin EP3 receptor in kidney tubules of male and female mice has no major effect on water homeostasis	11
Intersecting Transcriptomic Landscapes of Hypertension and Kidney Function in African American Women	11
Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress	11
Kir4.1/Kir5.1 of distal convoluted tubule is required for short-term angiotensin-II-induced stimulation of Na-Cl cotransporter	11
Proximal tubule cyclophilin D mediates kidney fibrogenesis in obstructive nephropathy	11
Pendrin regulation is prioritized by anion in high-potassium diets	11
Chronic kidney disease amplifies severe kidney injury and mortality in a mouse model of skin arsenical exposure	10
Exogenous pericyte delivery protects the mouse kidney from chronic ischemic injury	10
Practical notes on popular statistical tests in renal physiology	10
Influence of carnosine and carnosinase-1 on diabetes-induced afferent arteriole vasodilation: implications for glomerular hemodynamics	10
Amiloride lowers plasma TNF and interleukin-6 but not interleukin-17A in patients with hypertension and type 2 diabetes	10
Pretreatment with a novel Toll-like receptor 4 agonist attenuates renal ischemia-reperfusion injury	10
CRB2 depletion induces YAP signaling and disrupts mechanosensing in podocytes	10
Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia-reperfusion injury in a sex-dependent manner	10
Proteinuria is accompanied by intratubular complement activation and apical membrane deposition of C3dg and C5b-9 in kidney transplant recipients	10
Cystinosin-deficient rats recapitulate the phenotype of nephropathic cystinosis	10
Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort	10
Prevention of hypertension-induced renal vascular dysfunction through a p66Shc-targeted mechanism	10
JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice	10
Antibiotic-induced microbiome depletion alters renal glucose metabolism and exacerbates renal injury after ischemia-reperfusion injury in mice	10
Furin-mediated modification is required for epithelial sodium channel-activating activity of soluble (pro)renin receptor in cultured collecting duct cells	10
A brief harvesting-freezing delay significantly alters the kidney metabolome and leads to false positive and negative results	10
First Author Highlights	10
Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury	9
Flow-dependent transport processes 2024: filtration, absorption, secretion	9
Altered renal vascular patterning reduces ischemic kidney injury and limits age-associated vascular loss	9
Bayesian mapping of protein kinases to vasopressin-regulated phosphorylation sites in renal collecting duct	9
Promises and challenges of miRNA therapeutics	9
Inhibition of mTORC2 promotes natriuresis in Dahl salt-sensitive rats via the decrease of NCC and ENaC activity	9
Creatinine clearance is maintained in a range of wet-bulb globe temperatures and work-rest ratios during simulated occupational heat stress	9
Nicotinamide ameliorates podocyte injury and albuminuria in adriamycin-induced nephropathy	9
KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury	9
Male Akita mice develop signs of bladder underactivity independent of NLRP3 as a result of a decrease in neurotransmitter release from efferent neurons	9
Image analysis techniques to map pyramids, pyramid structure, glomerular distribution, and pathology in the intact human kidney from 3-D MRI	9
Mitochondrial dysfunction in the pathophysiology of renal diseases	9
First Author Highlights	9
β2-Adrenergic receptor agonists as a treatment for diabetic kidney disease	9
Transcription factor HNF1β controls a transcriptional network regulating kidney cell structure and tight junction integrity	9
The miR-143/145 cluster induced by TGF-β1 suppresses Wilms’ tumor 1 expression in cultured human podocytes	9
HMGB1 drives T-cell activation in hypertensive males and females	9
The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in the human kidney	9
HIF-1α is transcriptionally regulated by NF-κB in acute kidney injury	9
Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program	9
Mechanisms of decreased tubular flow-induced nitric oxide in Dahl salt-sensitive rat thick ascending limbs	8
Role of protease-activated receptor 4 in mouse models of acute and chronic kidney injury	8
Kidney functional reserve helps early detection of subclinical chronic kidney disease	8
High dietary salt intake increases urinary NGAL excretion and creatinine clearance in healthy young adults	8
Vascular control of kidney epithelial transporters	8
Tacrolimus induces fibroblast-to-myofibroblast transition via a TGF-β-dependent mechanism to contribute to renal fibrosis	8
Postoperative acute kidney injury after volatile or intravenous anesthesia: a meta-analysis	8
IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage	8
The degree of aortic occlusion in the setting of trauma alters the extent of acute kidney injury associated with mitochondrial preservation	8
Faster bladder filling in rats reduces detrusor overactivity but worsens (i.e., decreases) bladder compliance	8
IFT88 deficiency in proximal tubular cells exaggerates cisplatin-induced injury by suppressing autophagy	8
Fasting-induced HMGCS2 expression in the kidney does not contribute to circulating ketones	8
Endothelin-1 signaling in the kidney: recent advances and remaining gaps	8
Novel method for kinetic analysis applied to transport by the uniporter OCT2	8
First Author Spotlight	8
Predicting sex differences in the effects of diuretics in renal epithelial transport during angiotensin II-induced hypertension	8
Assays to enhance metabolic phenotyping in the kidney	8
Identification of cell division cycle protein 20 in various forms of acute and chronic kidney injury in mice	8
Diffusion tensor MRI is sensitive to fibrotic injury in a mouse model of oxalate-induced chronic kidney disease	8
Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation	8
Longitudinal intravital microscopy of the mouse kidney: inflammatory responses to abdominal imaging windows	8
A mathematical model of the rat kidney. III. Ammonia transport	7

A comparative modeling study of the mitochondrial function of the proximal tubule and thick ascending limb cells in the rat kidney	7
Cullin 3 mutant causing familial hyperkalemic hypertension lacks normal activity in the kidney	7
Metabolomic profiling to identify early urinary biomarkers and metabolic pathway alterations in autosomal dominant polycystic kidney disease	7
Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice	7
LncRNA GAS5 protects against TGF-β-induced renal fibrosis via the Smad3/miRNA-142-5p axis	7
Endothelial dysfunction in the aging kidney	7
Corrigendum for McKinzie et al., volume 326, 2024, p. F644–F660	7
The role of Gata3 in renin cell identity	7
SGLT2 inhibitors: not every drug has the same effect	7
Corrigendum for Martínez-Rojas et al., volume 323, 2022, p. F425–F434	7
Divergent roles of angiotensin II upon the immediate and sustained increases of renal blood flow following unilateral nephrectomy	7
Chronic central nervous system leptin administration attenuates kidney dysfunction and injury in a model of ischemia/reperfusion-induced acute kidney injury	7
Metabolic acidosis regulates RGS16 and G protein signaling in osteoblasts	7
The evolving concepts of KS-WNK1 effect on NCC activity	7
First Author Highlights	7
Pathways and parameters of sacral neuromodulation in rats	7
2024 Carl W. Gottschalk Distinguished Lectureship of the American Physiological Society Renal Section	7
The knock-out of paracingulin attenuates hypertension through modulation of kidney ion transport	7
Sex differences in circadian regulation of kidney function of the mouse	7
Western diet exacerbates a murine model of Balkan nephropathy	7
The unique structural and functional characteristics of glomerular endothelial cell fenestrations and their potential as a therapeutic target in kidney disease	7
Hepatic and proximal tubule angiotensinogen play distinct roles in kidney dysfunction, glomerular and tubular injury, and fibrosis progression	6
Endothelin receptor B is required for the blood pressure-lowering effect of G protein-coupled estrogen receptor 1 in ovariectomized rats	6
The influence of intermittent hypoxia, obesity, and diabetes on male genitourinary anatomy and voiding physiology	6
Role of the renal androgen receptor in sex differences in ammonia metabolism	6
First Author Highlights	6
Synaptopodin deficiency exacerbates kidney disease in a mouse model of Alport syndrome	6
Intestinal barrier function declines during polycystic kidney disease progression	6
Myo-inositol oxygenase in cadmium-induced kidney injury	6
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake	6
The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu)	6
Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes	6
Lung cancer-kidney cross talk induces kidney injury, interstitial fibrosis, and enhances cisplatin-induced nephrotoxicity	6
Renal calcium and magnesium handling during pregnancy: modeling and analysis	6
KV7.1 channel blockade inhibits neonatal renal autoregulation triggered by a step decrease in arterial pressure	6
Circadian gene expression in mouse renal proximal tubule	6
Anatomic and functional evidence for renal autonomic innervation in normotensive and hypertensive rats	6
Expression and distribution of MUC1 in the developing and adult kidney	6
Role of coagulation in persistent renal ischemia following reperfusion in an animal model	6
Transition from acute kidney injury to chronic kidney disease: mechanisms, models, and biomarkers	6
Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na+ and K+	6
Functional NADPH oxidase 2 in T cells amplifies salt-sensitive hypertension and associated renal damage	6
Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect	6
Kidney stone formation in a novel murine model of polycystic kidney disease	6
Effect of sex chromosome complement versus gonadal hormones on abundance of renal transporters	6
Histamine receptors rapidly desensitize without altering nerve-evoked contractions in murine urinary bladder smooth muscle	6
PLVAP: the new villain in glomerular endothelial cell injury	6
Corrigendum for Hu QH et al., Volume 297, 2009, p. F1080–F1091	6
Single-cell RNA sequencing and spatial transcriptomics reveal unique subpopulations of infiltrating macrophages and dendritic cells following AKI	6
Specialized proresolution mediators in the bladder: annexin-A1 normalizes inflammation and bladder dysfunction during bladder outlet obstruction	6
Raising serum uric acid with a uricase inhibitor worsens PKD in rat and mouse models	5
Modulation of blood pressure by dietary potassium and sodium: sex differences and modeling analysis	5
Induction of plasmalemmal vesicle-associated protein exacerbates glomerular endothelial injury in thrombotic microangiopathy	5
Diabetes causes NLRP3-dependent barrier dysfunction in mice with detrusor overactivity but not underactivity	5
The Janus view: dual roles for hypoxia-inducible factor in renal repair after acute kidney injury	5
Caspase-3-dependent peritubular capillary dysfunction is pivotal for the transition from acute to chronic kidney disease after acute ischemia-reperfusion injury	5
Angiotensin (1–7) protects against renal ischemia-reperfusion injury via regulating expression of NRF2 and microRNAs in Fisher 344 rats	5
Tips on navigating the first year of graduate school for individuals from historically excluded backgrounds	5
Podocyte injury at young age causes premature senescence and worsens glomerular aging	5
Kidney-specific KO of the circadian clock protein PER1 alters renal Na+ handling, aldosterone levels, and kidney/adrenal gene expression	5
Guidelines on antibody use in physiology research	5
Ribosomal s6 kinase is a mediator of aquaporin-2 S256 phosphorylation and membrane accumulation after EGFR inhibition with erlotinib	5
The FSGS protein actinin-4 interacts with NKCC2 to regulate thick ascending limb NaCl reabsorption	5
Renal mass reduction increases the response to exogenous insulin independent of acid-base status or plasma insulin levels in rats	5
Impact of bedding on Dahl salt-sensitive hypertension and renal damage	5
Could an intrarenal Cori cycle participate in the urinary concentrating mechanism?	5
Wilms’ tumor gene 1: lessons from the interface between kidney development and cancer	5
Generation of Atp6v1g3-Cre mice for investigation of intercalated cells and the collecting duct	5
Oxysterol-binding protein-like 7 deficiency leads to ER stress-mediated apoptosis in podocytes and proteinuria	5
Sex-specific modulation of renal epigenetic and injury markers in aging kidney	5
Endothelial cells: potential novel regulators of renal inflammation	5
Persistence and expansion of hypoxia detected by pimonidazole adduct immunostaining during progression of diabetic nephropathy in diabetic mice	5
Exercise for patients with chronic kidney disease: from cells to systems to function	5
Chronic environmental hypoxia attenuates innate immunity activation and renal injury in two CKD models	5
Amiloride evokes significant natriuresis and weight loss in kidney transplant recipients with and without albuminuria	5
Autophagy and mitophagy: physiological implications in kidney inflammation and diseases	5
Proximal tubule pannexin 1 contributes to mitochondrial dysfunction and cell death during acute kidney injury	5
Role of the SLC22A17/lipocalin-2 receptor in renal endocytosis of proteins/metalloproteins: a focus on iron- and cadmium-binding proteins	5
First Author Spotlight	5
The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials	5
Early-life exposures and long-term health: adverse gestational environments and the programming of offspring renal and vascular disease	5
First Author Highlights	4
First Author Spotlight	4
Kcnma1 alternative splicing in mouse kidney: regulation during development and by dietary K+ intake	4
Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model	4
Mutagenesis of the cleavage site of (pro)renin receptor abrogates aldosterone-salt-induced hypertension and renal injury in mice	4
First Author Spotlight	4
Glucagon receptor activation contributes to the development of kidney injury	4
Strategies to mitigate acute kidney injury risk during physical work in the heat	4
The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain	4
Renal injury in relation to obesity and the additive effect of hypertension in female and male obese and lean ZSF1 rats	4
First Author Spotlight	4
The calcium-sensing receptor has only a parathyroid hormone-dependent role in the acute response of renal phosphate transporters to phosphate intake	4
When ACE2 turns against the kidney: a paradox unveiled in heme-induced AKI	4
Characterizing the metabolic response of the zebrafish kidney to overfeeding	4