American Journal of Physiology-Renal Physiology

Article	Citations
Is the kidney a target of SARS-CoV-2?	149
Preeclampsia beyond pregnancy: long-term consequences for mother and child	127
A role for tubular Na+/H+exchanger NHE3 in the natriuretic effect of the SGLT2 inhibitor empagliflozin	120
Mitochondrial dysfunction and the AKI-to-CKD transition	97
Uric acid and inflammation in kidney disease	76
Sex differences in solute transport along the nephrons: effects of Na+transport inhibition	58
Mitochondrial transplantation by intra-arterial injection for acute kidney injury	51
The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction	46
Differences in renal BMAL1 contribution to Na+ homeostasis and blood pressure control in male and female mice	43
Effects of SGLT2 inhibitor and dietary NaCl on glomerular hemodynamics assessed by micropuncture in diabetic rats	40
Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model	40
Sex differences in renal ischemia-reperfusion injury	40
Distal convoluted tubule Cl−concentration is modulated via K+channels and transporters	38
Urine cytokines as biomarkers for diagnosing interstitial cystitis/bladder pain syndrome and mapping its clinical characteristics	36
Decreased secretion and profibrotic activity of tubular exosomes in diabetic kidney disease	35
ELABELA antagonizes intrarenal renin-angiotensin system to lower blood pressure and protects against renal injury	33
Exercise intolerance in kidney diseases: physiological contributors and therapeutic strategies	31
Distinct functions of megalin and cubilin receptors in recovery of normal and nephrotic levels of filtered albumin	31
Skeletal myopathy in CKD: a comparison of adenine-induced nephropathy and 5/6 nephrectomy models in mice	31
A plasma creatinine- and urea-based equation to estimate glomerular filtration rate in rats	31
Evolution of altered tubular metabolism and mitochondrial function in sepsis-associated acute kidney injury	31
Sex differences in renal mitochondrial function: a hormone-gous opportunity for research	29
Class IIa HDAC inhibitor TMP195 alleviates lipopolysaccharide-induced acute kidney injury	28
Nrf2 mediates hypoxia-inducible HIF1α activation in kidney tubular epithelial cells	28
Salt-sensitive hypertension in chronic kidney disease: distal tubular mechanisms	27

Effects of extreme potassium stress on blood pressure and renal tubular sodium transport	27
Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney	27
Distal convoluted tubule sexual dimorphism revealed by advanced 3D imaging	27
Gene knockout of the Na+-glucose cotransporter SGLT2 in a murine model of acute kidney injury induced by ischemia-reperfusion	26
Adaptive changes in single-nephron GFR, tubular morphology, and transport in a pregnant rat nephron: modeling and analysis	26
Cerebral blood flow regulation in end-stage kidney disease	25
Regulated cell death in cisplatin-induced AKI: relevance of myo-inositol metabolism	25
The complicated role of mitochondria in the podocyte	25
Critical role of the mineralocorticoid receptor in aldosterone-dependent and aldosterone-independent regulation of ENaC in the distal nephron	25
METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation	24
Pathophysiology of unilateral ischemia-reperfusion injury: importance of renal counterbalance and implications for the AKI-CKD transition	24
Histone deacetylase 6 inhibition mitigates renal fibrosis by suppressing TGF-β and EGFR signaling pathways in obstructive nephropathy	24
C57BL/6 mice require a higher dose of cisplatin to induce renal fibrosis and CCL2 correlates with cisplatin-induced kidney injury	23
Long noncoding RNA NEAT1 sponges miR-129 to modulate renal fibrosis by regulation of collagen type I	22
Disparate roles of retinoid acid signaling molecules in kidney disease	22
Mesenchymal stem cells protect renal tubular cells via TSG-6 regulating macrophage function and phenotype switching	22
Novel Fanconi renotubular syndromes provide insights in proximal tubule pathophysiology	22
Urinary bladder smooth muscle ion channels: expression, function, and regulation in health and disease	21
Regulation of mitochondrial dynamics and energetics in the diabetic renal proximal tubule by the β2-adrenergic receptor agonist formoterol	21
Fasting-induced HMGCS2 expression in the kidney does not contribute to circulating ketones	21
Liraglutide suppresses production of extracellular matrix proteins and ameliorates renal injury of diabetic nephropathy by enhancing Wnt/β-catenin signaling	20
Sacubitril/valsartan treatment has differential effects in modulating diabetic kidney disease in db/db mice and KKAy mice compared with valsartan treatment	20
Expression of lactate dehydrogenase A and B isoforms in the mouse kidney	20
Metformin arrests the progression of established kidney disease in the subtotal nephrectomy model of chronic kidney disease	20
Protective effect of d-alanine against acute kidney injury	20
HIF-1α is transcriptionally regulated by NF-κB in acute kidney injury	19
Intratubular epithelial-mesenchymal transition and tubular atrophy after kidney injury in mice	19
Localization and regulation of claudin-14 in experimental models of hypercalcemia	19
Roles of WNK4 and SPAK in K+-mediated dephosphorylation of the NaCl cotransporter	18
Rapid development of vasopressin resistance in dietary K+ deficiency	18
Kidney-specific KO of the circadian clock protein PER1 alters renal Na+ handling, aldosterone levels, and kidney/adrenal gene expression	18
Sex differences in circadian regulation of kidney function of the mouse	18
SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na+ transport in Dahl SS rats	18
Effects of uric acid dysregulation on the kidney	18
Overexpression of TGF-β1 induces renal fibrosis and accelerates the decline in kidney function in polycystic kidney disease	18
Endothelial cells: potential novel regulators of renal inflammation	18
TCR+CD4−CD8− (double negative) T cells protect from cisplatin-induced renal epithelial cell apoptosis and acute kidney injury	18
T cell-derived extracellular vesicles are elevated in essential HTN	17
Natural antibody and complement activation characterize patients with idiopathic nephrotic syndrome	17
Vitamin K deficiency: an emerging player in the pathogenesis of vascular calcification and an iatrogenic consequence of therapies in advanced renal disease	17
Alkali supplementation as a therapeutic in chronic kidney disease: what mediates protection?	17
Beneficial effect on podocyte number in experimental diabetic nephropathy resulting from combined atrasentan and RAAS inhibition therapy	17
Synaptopodin deficiency exacerbates kidney disease in a mouse model of Alport syndrome	17
Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy	17
Inhaled silica nanoparticles cause chronic kidney disease in rats	17
MiR-21 promotes calcium oxalate-induced renal tubular cell injury by targeting PPARA	16
Cubilin-, megalin-, and Dab2-dependent transcription revealed by CRISPR/Cas9 knockout in kidney proximal tubule cells	16
A naturally occurring FXR agonist, alisol B 23-acetate, protects against renal ischemia-reperfusion injury	16
Role of SIRT1 in HIV-associated kidney disease	16
Molecular targeting of renal inflammation using drug delivery technology to inhibit NF-κB improves renal recovery in chronic kidney disease	16

Potential risk of the kidney vulnerable to novel coronavirus 2019 infection	16
Soluble (pro)renin receptor promotes the fibrotic response in renal proximal tubule epithelial cells in vitro via the Akt/β-catenin/Snail signaling pathway	16
Ubiquitination of renal ENaC subunits in vivo	16
Metabolic reprogramming in a slowly developing orthologous model of polycystic kidney disease	16
RNA-Seq profiling of microdissected glomeruli identifies potential biomarkers for human IgA nephropathy	16
GLP-1-induced renal vasodilation in rodents depends exclusively on the known GLP-1 receptor and is lost in prehypertensive rats	15
Renal lymphatic vessel dynamics	15
1,3-Butanediol attenuates hypertension and suppresses kidney injury in female rats	15
Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease	15
Inhibition of interleukin-6 on matrix protein production by glomerular mesangial cells and the pathway involved	15
CBX7 suppression prevents ischemia-reperfusion injury-induced endoplasmic reticulum stress through the Nrf-2/HO-1 pathway	15
Increased SGK1 activity potentiates mineralocorticoid/NaCl-induced kidney injury	15
(Pro)renin receptor decoy peptide PRO20 protects against adriamycin-induced nephropathy by targeting the intrarenal renin-angiotensin system	15
The kidney protects against sepsis by producing systemic uromodulin	15
Chemokine CCL2 from proximal tubular epithelial cells contributes to sepsis-induced acute kidney injury	15
Blockade of STAT3 signaling alleviates the progression of acute kidney injury to chronic kidney disease through antiapoptosis	15
Lipotoxicity dysregulates the immunoproteasome in podocytes and kidneys in type 2 diabetes	15
IL-10 treatment decreases blood pressure in male, but not female, spontaneously hypertensive rats	15
Renal ischemia alters expression of mitochondria-related genes and impairs mitochondrial structure and function in swine scattered tubular-like cells	14
Effects of long-term intradialytic oral nutrition and exercise on muscle protein homeostasis and markers of mitochondrial content in patients on hemodialysis	14
Fibroblast growth factor 23 leads to endolysosomal routing of the renal phosphate cotransporters NaPi-IIa and NaPi-IIc in vivo	14
Aristolochic acid-induced nephropathy is attenuated in mice lacking the neutral amino acid transporter B0AT1 (Slc6a19)	14
Role of the polycystins as mechanosensors of extracellular stiffness	14
Mutation of RORγT reveals a role for Th17 cells in both injury and recovery from renal ischemia-reperfusion injury	14
Experimental nephrotic syndrome leads to proteolytic activation of the epithelial Na+ channel in the mouse kidney	14
AMP-activated protein kinase contributes to cisplatin-induced renal epithelial cell apoptosis and acute kidney injury	14
Involvement of the CDKL5-SOX9 signaling axis in rhabdomyolysis-associated acute kidney injury	14
G protein-coupled estrogen receptor 1 as a novel regulator of blood pressure	14
Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction	14
Differential localization patterns of claudin 10, 16, and 19 in human, mouse, and rat renal tubular epithelia	14
Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease	14
Zebrafish (Danio rerio) larva as an in vivo vertebrate model to study renal function	14
Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats	14
Silencing of the lncRNA TUG1 attenuates the epithelial-mesenchymal transition of renal tubular epithelial cells by sponging miR-141-3p via regulating β-catenin	14
Angiotensin type 2 receptor activation limits kidney injury during the early phase and induces Treg cells during the late phase of renal ischemia	14
Aldosterone-dependent and -independent regulation of Na+and K+excretion and ENaC in mouse kidneys	14
Beyond the tubule: pathological variants of LRP2, encoding the megalin receptor, result in glomerular loss and early progressive chronic kidney disease	13
Localization of angiotensin II type 1 receptor gene expression in rodent and human kidneys	13
Western diet induces renal artery endothelial stiffening that is dependent on the epithelial Na+ channel	13
Inward Ca2+ current through the polycystin-2-dependent channels of renal primary cilia	13
Autoimmunity to urothelial antigen causes bladder inflammation, pelvic pain, and voiding dysfunction: a novel animal model for Hunner-type interstitial cystitis	13
Impaired renal hemodynamics and glomerular hyperfiltration contribute to hypertension-induced renal injury	13
Nicotine, smoking, podocytes, and diabetic nephropathy	13
High dietary salt intake increases urinary NGAL excretion and creatinine clearance in healthy young adults	13
Expression and function of human ribonuclease 4 in the kidney and urinary tract	13
L-WNK1 is required for BK channel activation in intercalated cells	13
A new view of macula densa cell microanatomy	13
Role of the renal androgen receptor in sex differences in ammonia metabolism	13
NMR-based serum and urine metabolomic profile reveals suppression of mitochondrial pathways in experimental sepsis-associated acute kidney injury	13
Nonesterified free fatty acids enhance the inflammatory response in renal tubules by inducing extracellular ATP release	13
Phosphorylation of key podocyte proteins and the association with proteinuric kidney disease	13
CD4+ T cells cause renal and placental mitochondrial oxidative stress as mechanisms of hypertension in response to placental ischemia	13
Cleavage state of γENaC in mouse and rat kidneys	13
Dual blockade of protease-activated receptor 1 and 2 additively ameliorates diabetic kidney disease	13
Antibiotic-induced microbiome depletion alters renal glucose metabolism and exacerbates renal injury after ischemia-reperfusion injury in mice	12
Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension	12
Decreased IFT88 expression with primary cilia shortening causes mitochondrial dysfunction in cisplatin-induced tubular injury	12
Combinatorial expression of claudins in the proximal renal tubule and its functional consequences	12
Protein kinase A catalytic-α and catalytic-β proteins have nonredundant regulatory functions	12
Bayesian identification of candidate transcription factors for the regulation of Aqp2 gene expression	12
Deletion of renal Nedd4-2 abolishes the effect of high sodium intake (HS) on Kir4.1, ENaC, and NCC and causes hypokalemia during high HS	12
Gene expression profiling of proximal and distal renal tubules in Atlantic salmon (Salmo salar) acclimated to fresh water and seawater	12
Time-dependent progression of neurogenic lower urinary tract dysfunction after spinal cord injury in the mouse model	12
Landscape of GPCR expression along the mouse nephron	12
Physiology assays in human kidney organoids	12
SGLT2 inhibitor and loop diuretic induce different vasopressin and fluid homeostatic responses in nondiabetic rats	12
Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats	12
A two-stage bilateral ischemia-reperfusion injury-induced AKI to CKD transition model in mice	11
The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain	11
Single-cell mRNA profiling reveals changes in solute carrier expression and suggests a metabolic switch during zebrafish pronephros development	11
Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression	11
Inhibition of 15-PGDH prevents ischemic renal injury by the PGE2/EP4signaling pathway mediating vasodilation, increased renal blood flow, and increased adenosine/A2Are	11
Deletion of Kir5.1 abolishes the effect of high Na+ intake on Kir4.1 and Na+-Cl− cotransporter	11
IFT88 deficiency in proximal tubular cells exaggerates cisplatin-induced injury by suppressing autophagy	11
Circadian variation in renal blood flow and kidney function in healthy volunteers monitored with noninvasive magnetic resonance imaging	11
Porcine models of acute kidney injury	11
TAZ is important for maintenance of the integrity of podocytes	11
A mathematical model of the rat kidney. IV. Whole kidney response to hyperkalemia	11
Pendrin-null mice develop severe hypokalemia following dietary Na+ and K+ restriction: role of ENaC	11
Intracellular location of aquaporin-2 serine 269 phosphorylation and dephosphorylation in kidney collecting duct cells	11

Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells	11
Activation of TGR5 restores AQP2 expression via the HIF pathway in renal ischemia-reperfusion injury	11
WNK4 kinase: from structure to physiology	11
Chronic unilateral cervical vagotomy reduces renal inflammation, blood pressure, and renal injury in a mouse model of lupus	11
Mechanism of how carbamylation reduces albumin binding to FcRn contributing to increased vascular clearance	11
Comparison of the surgical resection and infarct 5/6 nephrectomy rat models of chronic kidney disease	11
PF-06869206 is a selective inhibitor of renal Pitransport: evidence from in vitro and in vivo studies	10
Protective role of DJ-1 in endotoxin-induced acute kidney injury	10
Mast cell function in prostate inflammation, fibrosis, and smooth muscle cell dysfunction	10
Hypertensive female Sprague-Dawley rats require an intact nitric oxide synthase system for compensatory increases in renal regulatory T cells	10
Urinary DPP4 correlates with renal dysfunction, and DPP4 inhibition protects against the reduction in megalin and podocin expression in experimental CKD	10
Proteinuria is accompanied by intratubular complement activation and apical membrane deposition of C3dg and C5b-9 in kidney transplant recipients	10
Systemic inhibition of miR-451 increases fibrotic signaling and diminishes autophagic response to exacerbate renal damage in Tallyho/Jng mice	10
A call to action to evaluate renal functional reserve in patients with COVID-19	10
A uropathogenic E. coli UTI89 model of prostatic inflammation and collagen accumulation for use in studying aberrant collagen production in the prostate	10
Early antihypertensive treatment and ischemia-induced acute kidney injury	10
Renal claudin-14 expression is not required for regulating Mg2+ balance in mice	10
Myo-inositol oxygenase overexpression exacerbates cadmium-induced kidney injury via oxidant stress and necroptosis	10
High baseline ROMK activity in the mouse late distal convoluted and early connecting tubule probably contributes to aldosterone-independent K+ secretion	10
Transient receptor potential cation channel 6 contributes to kidney injury induced by diabetes and hypertension	10
Mitochondria as mediators of systemic inflammation and organ cross talk in acute kidney injury	10
Podocyte endowment and the impact of adult body size on kidney health	10
Pathomorphological sequence of nephron loss in diabetic nephropathy	10