OOIR: Observatory of International Research

Papers

(The TQCC of Antioxidants & Redox Signaling is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
The KEAP1-NRF2 system and neurodegenerative diseases	242
The redox protein HMGB1 in cell death and cancer	144
Disturbance of Fetal Growth by Azithromycin Through Induction of ER Stress in the Placenta	123
Blood–Labyrinth Barrier in Health and Diseases: Effect of Hormetic Nutrients	118
Mitochondrial Mechanisms in Immunity and Inflammatory Conditions: Beyond Energy Management	106
MicroRNA-Mediated Mitochondrial Dysfunction Is Involved in the Anti-triple-Negative Breast Cancer Cell Activity of Phytosesquiterpene Lactones	105
Impact of Mitochondrial Architecture, Function, Redox Homeostasis, and Quality Control on Organismic Aging: Lessons from a Fungal Model System	100
Mild Therapeutic Hypothermia and Putative Mechanisms of Hair Cell Survival in the Cochlea	87
Status of Blood Levels of Superoxide Dismutase in Patients with Malaria: A Systematic Review and Meta-Analysis	83
Redox Control of Integrin-Mediated Hepatic Inflammation in Systemic Autoimmunity	80
Modes of Mitochondrial Reactive Oxygen Species Production in Inflammation	80
The Use of Multiplexing to Identify Cytokine and Chemokine Networks in the Immune-Inflammatory Response to Trauma	77
Does NLRP1 Inflammasome Activation in Immune Cells in Kidney Transplantation Relate with Donor Organ Age?	73
Oxidative Stress, Transfer RNA Metabolism, and Protein Synthesis	72
Cystathionine γ-Lyase Attenuates Vascular Smooth Muscle Cell Senescence via Foxm1-Gas1 Pathway to Mediate Arterial Stiffness	70
ERO1-PDI Redox Signaling in Health and Disease	70
The Antioxidant Ergothioneine Alleviates Cisplatin-Induced Hearing Loss Through the Nrf2 Pathway	60
Exosomal Prolactin-Induced Protein Inhibits the Activation of cGMP/PKG Pathway Mediated by ATP2B2 to Promote Myocardial Fibrosis in Atrial Fibrillation	59
Modulation of Innate Immune Memory Dynamics by Subcellular Reactive Oxygen Species	56
Reactive Oxygen Species and Their Consequences on the Structure and Function of Mammalian Spermatozoa	55
Nogo-B Promotes Endoplasmic Reticulum Stress-Mediated Autophagy in Endothelial Cells of Diabetic Nephropathy	55
Emerging Chemical Biology of Protein Persulfidation	53
Contribution of Mitochondria to Insulin Secretion by Various Secretagogues	51
The Role of Perivascular Adipose Tissue-Derived Hydrogen Sulfide in the Control of Vascular Homeostasis	51
Pathological Impact of Redox Post-Translational Modifications	50

Redox Signaling and Stress in Inherited Myopathies	47
Ferroptosis As Ultimate Target of Cancer Therapy	46
Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma	45
Oxidative Stress and Pyroptosis Mediated by CEBPB/HMGB1 Signaling in Sepsis-Exacerbated Coronary Atherosclerosis	45
Altered Metabolism in Alzheimer Disease Brain: Role of Oxidative Stress	43
Regulation of Erythroid Differentiation via the HIF1α-NFIL3-PIM1 Signaling Axis Under Hypoxia	42
Does SLC39A8 Ala391Thr Confer Risk of Chronic Liver Disease?	40
Pathomechanistic Synergy Between Particulate Matter and Traffic Noise-Induced Cardiovascular Damage and the Classical Risk Factor Hypertension	39
The Emergence of Tumor-Initiating Cells in an Advanced Hypopharyngeal Tumor Model Exhibits Enhanced Angiogenesis and Nuclear Factor Erythroid 2-Related Factor 2-Associated Antioxidant Effects	37
Soluble Carrier Transporters and Mitochondria in the Immunometabolic Regulation of Macrophages	37
Urinary Matrix Metalloproteinase 7 Activated by Oxidative Stress Predicts Kidney Prognosis in Myeloperoxidase–Antineutrophil Cytoplasmic Antibody-Associated Vasculitis	37
Structure and Function of Redox-Sensitive Superfolder Green Fluorescent Protein Variant	37
Preferential Secretion of Oxidation-Sensitive Proteins by Unconventional Pathways: Why is This Important for Inflammation?	37
Chemiluminescence Measurement of Reactive Sulfur and Nitrogen Species	37
Selenocompounds and Sepsis—Redox Bypass Hypothesis: Part B-Selenocompounds in the Management of Early Sepsis	36
PDK4 Decrease Neuronal Apoptosis via Inhibiting ROS-ASK1/P38 Pathway in Early Brain Injury After Subarachnoid Hemorrhage	36
Alpha-Tocopherol from People to Plants Is an Essential Cog in the Metabolic Machinery	35
TXNIP Exacerbates the Senescence and Aging-Related Dysfunction of β Cells by Inducing Cell Cycle Arrest Through p38-p16/p21-CDK-Rb Pathway	35
Potential of Cytochrome P450, a Family of Xenobiotic Metabolizing Enzymes, in Cancer Therapy	35
The Reactive Species Interactome in the Brain	34
Mechanistic Insights into Alternative Gene Splicing in Oxidative Stress and Tissue Injury	34
Comparison of the Nitric Oxide Synthase Interactomes and S-Nitroso-Proteomes: Furthering the Case for Enzymatic S-Nitrosylation	34
Systemic Mutation of Ncf1 Ameliorates Obstruction-Induced Renal Fibrosis While Macrophage-Rescued NCF1 Further Alleviates Renal Fibrosis	33
Oxygen Sensing in Innate Immune Cells: How Inflammation Broadens Classical Hypoxia-Inducible Factor Regulation in Myeloid Cells	33
Modulation of NRF2: Biological Dualism in Cancer, Targets and Possible Therapeutic Applications	32
Calcium Homeostasis in the Control of Mitophagy	32
4-Hydroxynonenal Promotes Colorectal Cancer Progression Through Regulating Cancer Stem Cell Fate	32
Hypoxia-Induced Changes in Endothelial Cell Phenotype and Function	32
Targeting Toll-Like Receptors in Sepsis: From Bench to Clinical Trials	31
Evidence for Constitutive Microbiota-Dependent Short-Term Control of Food Intake in Mice: Is There a Link with Inflammation, Oxidative Stress, Endotoxemia, and GLP-1?	31
What Is the Redox Potential of Ergothioneine?	31
Nuclear Factor Erythroid 2 Related Factor 2 and Mitochondria Form a Mutually Regulating Circuit in the Prevention and Treatment of Metabolic Syndrome	31
Environmental Chemical-Induced Reactive Oxygen Species Generation and Immunotoxicity: A Comprehensive Review	30
Sirtuins: The NAD⁺-Dependent Multifaceted Modulators of Inflammation	30
Hydrogen Sulfide in Diabetic Complications Revisited: The State of the Art, Challenges, and Future Directions	30
Nicotinamide Adenine Dinucleotide Precursor Supplementation Modulates Neurite Complexity and Survival in Motor Neurons from Amyotrophic Lateral Sclerosis Models	29
Impacts of Radiation on Metabolism and Vascular Cell Senescence	29
α-Ketoglutarate Attenuates Hyperlipidemia-Induced Endothelial Damage by Activating the Erk-Nrf2 Signaling Pathway to Inhibit Oxidative Stress and Mitochondrial Dysfunction	29
Reflections of an Aging Free Radical Part 2: Meeting Inspirational People	28
Reversal of Epigenetic Peroxisome Proliferator-Activated Receptor-γ Suppression by Diacerein Alleviates Oxidative Stress and Osteoarthritis in Mice	28
ARS Forum Oxygen Sensing	28
Vitamin C (Ascorbate) and Redox Topics in Cancer	27
High Incidence of Lethal Ventricular Arrhythmia-Sudden Cardiac Death in Early Myocardial Ischemia: Critical Roles of Cross-Regulation Between Stresses and Calcium Imbalance	27
Gasotransmitter-Mediated Cysteinome Oxidative Posttranslational Modifications: Formation, Biological Effects, and Detection	27
Tetrahydrobiopterin in Cell Function and Death Mechanisms	27
Increased Neuronal Nitric Oxide Synthase in Alzheimer's Disease Mediates Spontaneous Calcium Signaling and Divergent Glutamatergic Calcium Responses	27
PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARα Activation in Rats Fed High-Fat Diet	27
Cardiovascular Effects of Environmental Metal Antimony: Redox Dyshomeostasis as the Key Pathogenic Driver	27
NADPH Oxidases in Neurodegenerative Disorders: Mechanisms and Therapeutic Opportunities	26
Rosalind Franklin Society Proudly Announces the 2023 Award Recipient for Antioxidants & Redox Signaling	26

ALOX15 Modulates Ferroptosis via the Reactive Oxygen Species-Mediated MAPK Pathway in Doxorubicin-Induced Cardiotoxicity	26
Correction to: H₂S-Generating Cytosolic L-Cysteine Desulfhydrase and Mitochondrial D-Cysteine Desulfhydrase from Sweet Pepper (Capsicum annuum L.) Are Regulated During Fruit R	25
Thrombosis and Aging: Fibrin Clot Properties and Oxidative Stress	25
A Novel Synthesized Cyclohexane-Hydroxytyrosol Derivative Suppresses Ovarian Cancer Cell Growth Through Inducing Reactive Oxidative Species and Blocking Autophagic Flux	25
Inhibition of Fatty Acid Translocase (FAT/CD36) Palmitoylation Enhances Hepatic Fatty Acid β-Oxidation by Increasing Its Localization to Mitochondria and Interaction with Long-Chain Acyl-CoA Synthetas	24
Divergent Sepsis Pathophysiology in Older Adults	24
Mitochondrial Redox Signaling in O₂-Sensing Chemoreceptor Cells	24
Development of Hydropersulfide Donors to Study Their Chemical Biology	24
Hydrogen Sulfide Regulates Macrophage Function in Cardiovascular Diseases	23
Urinary Thioredoxin as a Biomarker of Renal Redox Dysregulation and a Companion Diagnostic to Identify Responders to Redox-Modulating Therapeutics	23
Sirtuin 5 Alleviates Liver Ischemia/Reperfusion Injury by Regulating Mitochondrial Succinylation and Oxidative Stress	23
Specialized Pro-Resolving Mediators Derived from N-3 Polyunsaturated Fatty Acids: Role in Metabolic Syndrome and Related Complications	23
CELLULAR STRESS RESPONSE (HORMESIS) IN RESPONSE TO BIOACTIVE NUTRACEUTICALS WITH RELEVANCE TO ALZHEIMER DISEASE	23
Radiation-Induced Bystander Effect on the Genome of Bone Marrow Mesenchymal Stem Cells in Lung Cancer	23
Epigenetic Control of Redox Pathways in Cancer Progression	23
Corrigendum to: “Angiotensin-Converting Enzyme-Dependent Intrarenal Angiotensin II Contributes to CTP: Phosphoethanolamine Cytidylyltransferase Downregulation, Mitochondrial	22
Oxygen Sensing in Neurodegenerative Diseases: Current Mechanisms, Implication of Transcriptional Response, and Pharmacological Modulation	22
Adaptive Responses to Hypoxia and/or Hyperoxia in Humans	22
Adaptive and Pathological Outcomes of Radiation Stress-Induced Redox Signaling	22
Thiol-Based Modification of MarR Protein VnrR Regulates Resistance Toward Nitrofuran in Vibrio cholerae By Promoting the Expression of a Novel Nitroreductase VnrA and of NO-Detoxifying Enzyme H	22
A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex	22
Exosomal miR-196a-5p Secreted by Bone Marrow Mesenchymal Stem Cells Inhibits Ferroptosis and Promotes Drug Resistance of Acute Myeloid Leukemia	21
The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling	21
Advances in the Functions of Thioredoxin System in Central Nervous System Diseases	21
High Uric Acid Orchestrates Ferroptosis to Promote Cardiomyopathy Via ROS-GPX4 Signaling	21
Crucial Roles of Ubiquitin Carboxy-Terminal Hydrolase L1 in Motor Neuronal Health byDrosophilaModel	21
Physiological and Pathophysiological Roles of Thioredoxin Interacting Protein: A Perspective on Redox Inflammation and Metabolism	21
Reactive Sulfur Species in Human Diseases	20
KRIT1: A Traffic Warden at the Busy Crossroads Between Redox Signaling and the Pathogenesis of Cerebral Cavernous Malformation Disease	20
Insights Into Antioxidant Strategies to Counteract Radiation-Induced Male Infertility	20
Succinate Activates Uncoupling Protein 2 to Suppress Neuroinflammation and Confer Protection Following Intracerebral Hemorrhage	20
Reactive Oxygen Species/Reactive Nitrogen Species as Messengers in the Gut: Impact on Physiology and Metabolic Disorders	20
Circulating Extracellular Vesicles Contain Liver-Derived RNA Species as Indicators of Severe Cholestasis-Induced Early Liver Fibrosis in Mice	20
Alterations in Mitochondrial Function in Pulmonary Vascular Diseases	19
Sestrin 2 Deficiency Exacerbates Noise-Induced Cochlear Injury Through Inhibiting ULK1/Parkin-Mediated Mitophagy	19
Role of Excessive Mitochondrial Fission in Seawater Immersion Aggravated Hemorrhagic Shock–Induced Cardiac Dysfunction and the Protective Effect of Mitochondrial Division Inhibitor-1	19
Biological Sex As a Critical Variable in CD4⁺Effector T Cell Function in Preclinical Models of Multiple Sclerosis	19
Impact of Acute and Chronic Psychosocial Stress on Vascular Inflammation	18
Hydrogen Sulfide and Functional Therapy: Novel Mechanisms from Epigenetics	18
Enduring Reactive Oxygen Species Emission Causes Aberrant Protein S-Glutathionylation Transitioning Human Aortic Valve Cells from a Sclerotic to a Stenotic Phenotype	18
Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging	18
Pleiotropic Regulation of PGC-1α in Tumor Initiation and Progression	18
Exploring the Molecular Interplay Between Oxygen Transport, Cellular Oxygen Sensing, and Mitochondrial Respiration	18
RNA and RNA Derivatives: Light and Dark Sides in Cancer Immunotherapy	17
Nitric oxide derived from cytoglobin-deficient hepatic stellate cells causes suppression of cytochrome c oxidase activity in hepatocytes	17
Targeting Neuroimmune Interactions in Diabetic Neuropathy with Nanomedicine	17
Sodium in Mitochondrial Redox Signaling	17
Modulation of Protein Disulfide Isomerase Functions by Localization: The Example of the Anterior Gradient Family	17
CircGNAQ Promotes Intracranial Aneurysm Formation by Facilitating Vascular Smooth Muscle Cell Phenotypic Switching and Apoptosis	17
Sulfur Dioxide Alleviates Aortic Dissection Through Inhibiting Vascular Smooth Muscle Cell Phenotype Switch, Migration, and Proliferation via miR-184-3p/Cyp26b1 Axis	17
GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Attenuates Skeletal Muscle Abnormalities in a Murine Model of Duchenne Muscular Dystrophy	17
Methods for Suppressing Hydrogen Sulfide in Biological Systems	17
Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills	17
Histone demethylase KDM5D represses the proliferation, migration and invasion of hepatocellular carcinoma through the E2F1/TNNC1 axis	17
Targeting NADPH Oxidase with APX-115: Suppression of Platelet Activation and Thrombotic Response	16
Spatiotemporal Characteristics Determining the Multifaceted Nature of Reactive Oxygen, Nitrogen, and Sulfur Species in Relation to Proton Homeostasis	16
RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα	16
Manganese-Induced Oxidative Stress Contributes to Intestinal Lipid Depositionviathe Deacetylation of PPARγ at K339 by SIRT1	16
Remote Organ Damage Induced by Stroke: Molecular Mechanisms and Comprehensive Interventions	16
Targeting the HNRNPA2B1/HDGF/PTN Axis to Overcome Radioresistance in Non-Small Cell Lung Cancer	16
Intrinsic and Induced Neuronal Regeneration in the Mammalian Retina	16
NAD⁺, Axonal Maintenance, and Neurological Disease	16
Aging and Antithrombotic Treatment	16
Peripubertal Bisphenol A Exposure Imparts Detrimental Age-Related Changes in Body Composition, Cognition, and Hydrogen Sulfide Production Capacities	16
Mitochondrial DNA Copy Number: Linking Diabetes and Cancer	16