OOIR: Observatory of International Research

Papers

(The TQCC of Antioxidants & Redox Signaling is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
The Antioxidant Ergothioneine Alleviates Cisplatin-Induced Hearing Loss Through the Nrf2 Pathway	184
Disturbance of Fetal Growth by Azithromycin Through Induction of ER Stress in the Placenta	132
ALOX15 Aggravates Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice with Type 2 Diabetes via Activating the PPARγ/CD36 Axis	104
Dual Oxygen-Responsive Control by RegSR of Nitric Oxide Reduction in the Soybean Endosymbiont Bradyrhizobium diazoefficiens	94
Uncoupling Proteins in Striated Muscle Tissue: Known Facts and Open Questions	91
Cystathionine γ-Lyase Attenuates Vascular Smooth Muscle Cell Senescence via Foxm1-Gas1 Pathway to Mediate Arterial Stiffness	90
MicroRNA-Mediated Mitochondrial Dysfunction Is Involved in the Anti-triple-Negative Breast Cancer Cell Activity of Phytosesquiterpene Lactones	87
Bach1 Deficiency Ameliorates Radiation Pneumonitis via Activating TFAM Signaling Pathway	80
Oxygen in Metabolic Dysfunction and Its Therapeutic Relevance	78
Circulating Extracellular Vesicles Contain Liver-Derived RNA Species as Indicators of Severe Cholestasis-Induced Early Liver Fibrosis in Mice	77
Oxidative Stress, Transfer RNA Metabolism, and Protein Synthesis	76
The Role of Oxidative Stress and Inflammation in Cardiometabolic Health of Children During Cancer Treatment and Potential Impact of Key Nutrients	72
High Uric Acid Orchestrates Ferroptosis to Promote Cardiomyopathy Via ROS-GPX4 Signaling	71
Re: “COVID-19: A Redox Disease—What a Stress Pandemic Can Teach Us About Resilience and What We May Learn from the Reactive Species Interactome About Its Treatment” by Cumpstey et al.	70
Influenza A Virus Hemagglutinin Is Produced in Different Disulfide-Bonded States	64
DAMPening Tumor Immune Escape: The Role of Endoplasmic Reticulum Chaperones in Immunogenic Chemotherapy	63
Uncovering the Molecular Link Between Lead Toxicity and Parkinson's Disease	61
The Use of Multiplexing to Identify Cytokine and Chemokine Networks in the Immune-Inflammatory Response to Trauma	60
The Interplay Between Mitochondrial Reactive Oxygen Species, Endoplasmic Reticulum Stress, and Nrf2 Signaling in Cardiometabolic Health	57
Modulatory Role of Carbon Monoxide on the Inflammatory Response and Oxidative Stress Linked to Gastrointestinal Disorders	56
NEAT1 Regulates Calcium Oxalate Crystal-Induced Renal Tubular Oxidative Injury via miR-130/IRF1	54
The KEAP1-NRF2 system and neurodegenerative diseases	54
Influences of Glaucoma on the Structure and Function of Synapses in the Visual System	52
Mild Therapeutic Hypothermia and Putative Mechanisms of Hair Cell Survival in the Cochlea	51
Where in the Tissues of Danio rerio Is More H₂O₂ Produced During Acute Hypoxia?	51

Metabolic and Redox Regulation of Cardiovascular Stem Cell Biology and Pathology	49
Roles of Ion Fluxes, Metabolism, and Redox Balance in Cancer Therapy	49
A Minimal Kynurenine Pathway Was Preserved for Rhodoquinone but Not for De Novo NAD⁺ Biosynthesis in Parasitic Worms: The Essential Role of NAD⁺ Rescue Pathways	46
Metabolomic Profiles of Human Glioma Inform Patient Survival	46
Evofosfamide and Gemcitabine Act Synergistically in Pancreatic Cancer Xenografts by Dual Action on Tumor Vasculature and Inhibition of Homologous Recombination DNA Repair	43
Oxidative Cysteine Modification of Thiol Isomerases in Thrombotic Disease: A Hypothesis	43
Advances in the Functions of Thioredoxin System in Central Nervous System Diseases	43
Ribonucleic Acid-Mediated Control of Protein Translation Under Stress	43
A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex	42
Selective Clearance of Senescent Chondrocytes in Osteoarthritis by Targeting Excitatory Amino Acid Transporter Protein 1 to Induce Ferroptosis	41
Crucial Roles of Ubiquitin Carboxy-Terminal Hydrolase L1 in Motor Neuronal Health byDrosophilaModel	40
Cardiovascular Risk Stratification Based on Oxidative Stress for Early Detection of Pathology	37
The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling	37
Impact of Mitochondrial Architecture, Function, Redox Homeostasis, and Quality Control on Organismic Aging: Lessons from a Fungal Model System	37
Is Mitochondrial DNA Copy Number from Human Blood Associated with Iron Deposits in the Brain?	36
Tumor Niches: Perspectives for Targeted Therapies in Glioblastoma	36
Physiological and Pathophysiological Roles of Thioredoxin Interacting Protein: A Perspective on Redox Inflammation and Metabolism	35
Dietary Sugar Shifts Mitochondrial Metabolism and Small RNA Biogenesis in Sperm	35
Blood–Labyrinth Barrier in Health and Diseases: Effect of Hormetic Nutrients	35
Polysulfide Protects Against Diabetic Cardiomyopathy Through Sulfhydration of Peroxisome Proliferator-Activated Receptor-γ and Sirtuin 3	35
Lactic Acidosis in Patients with Solid Cancer	34
Role of Metabolism in Adoptive T Cell Therapy: Strategies and Challenges	34
Does NLRP1 Inflammasome Activation in Immune Cells in Kidney Transplantation Relate with Donor Organ Age?	34
Reactive Oxygen Species/Reactive Nitrogen Species as Messengers in the Gut: Impact on Physiology and Metabolic Disorders	34
Redox Control of Integrin-Mediated Hepatic Inflammation in Systemic Autoimmunity	33
Regulation of Mitochondrial Quality Control of Intestinal Stem Cells in Homeostasis and Diseases	32
The Role of Iron in Benign and Malignant Hematopoiesis	32
Status of Blood Levels of Superoxide Dismutase in Patients with Malaria: A Systematic Review and Meta-Analysis	32
T Cell Nrf2/Keap1 Gene Editing Using CRISPR/Cas9 and Experimental Kidney Ischemia-Reperfusion Injury	31
High Level of Selenium Exposure in the Strong Heart Study: A Cause for Incident Cardiovascular Disease?	31
Inhibition of Trimethylamine N-Oxide Attenuates Neointimal Formation Through Reduction of Inflammasome and Oxidative Stress in a Mouse Model of Carotid Artery Ligation	31
Run, Ribosome, Run: From Compromised Translation to Human Health	31
Arterial Tortuosity Syndrome: An Ascorbate Compartmentalization Disorder?	30
The Multifaceted ATPase Inhibitory Factor 1 (IF1) in Energy Metabolism Reprogramming and Mitochondrial Dysfunction: A New Player in Age-Associated Disorders?	29
Nitric Oxide: Regulation and Function in Neutrophil Immune Responses	29
Hydrogen Sulfide Signaling in Plants	29
Metabolic Responses to Redox Stress in Vascular Cells	29
Development of Calcium-Dependent Phospholipase A2 Inhibitors to Target Cellular Senescence and Oxidative Stress in Neurodegenerative Diseases	29
Dynamic Regulation of Ferroptosis by Lipid Metabolism	29
Endothelial Cell-Derived Cholesterol Crystals Promote Endothelial Inflammation in Early Atherogenesis	29
A Core NRF2 Gene Set Defined Through Comprehensive Transcriptomic Analysis Predicts Selective Drug Resistance and Poor Multicancer Prognosis	28
Mitochondrial Mechanisms in Immunity and Inflammatory Conditions: Beyond Energy Management	28
Adverse Effects of Nrf2 in Different Organs and the Related Diseases	28
Anthracycline-Induced Atrial Structural and Electrical Remodeling Characterizes Early Cardiotoxicity and Contributes to Atrial Conductive Instability and Dysfunction	27
Molecular Determinants of Mitochondrial Shape and Function and Their Role in Glaucoma	27
Mitochondrial Ca²⁺ and Reactive Oxygen Species in Trypanosomatids	27
The redox protein HMGB1 in cell death and cancer	26
Insufficient S-Sulfhydration of Methylenetetrahydrofolate Reductase Contributes to the Progress of Hyperhomocysteinemia	25
Pyroptosis, Metabolism, and Oxidation in Tumorigenesis: Mechanisms and Therapeutic Implications	25
Reactive Sulfur Species in Human Diseases	25

Extracellular Matrix and Oxidative Stress Following Traumatic Spinal Cord Injury: Physiological and Pathophysiological Roles and Opportunities for Therapeutic Intervention	25
Sulfur Dioxide: Endogenous Generation, Biological Effects, Detection, and Therapeutic Potential	25
Gasping for Sulfide: A Critical Appraisal of Hydrogen Sulfide in Lung Disease and Accelerated Aging	25
Dysregulation of Iron Homeostasis in the Central Nervous System and the Role of Ferroptosis in Neurodegenerative Disorders	25
Structural and Functional Diversity of the Peroxiredoxin 6 Enzyme Family	24
Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation	24
Procyanidin B2 Promotes Intestinal Injury Repair and Attenuates Colitis-Associated Tumorigenesis via Suppression of Oxidative Stress in Mice	24
ERO1-PDI Redox Signaling in Health and Disease	23
Thioredoxin-1 Downregulation in the SNpc Exacerbates the Cognitive Impairment Induced by MPTP	23
Exercise Attenuates Myocardial Ischemia-Reperfusion Injury by Regulating Endoplasmic Reticulum Stress and Mitophagy Through M₂ Acetylcholine Receptor	23
New Therapeutic Approaches Using Hydrogen Sulfide Donors in Inflammation and Immune Response	22
miR-210 hypoxamiR in Angiogenesis and Diabetes	22
The Redox Protein High-Mobility Group Box 1 in Cell Death and Cancer	22
Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension	22
In Vivo Dynamic Nuclear Polarization Magnetic Resonance Imaging for the Evaluation of Redox-Related Diseases and Theranostics	21
Preconditioning Exercise Inhibits Neuron Ferroptosis and Ameliorates Brain Ischemia Damage by Skeletal Muscle–Derived Exosomes via Regulating miR-484/ACSL4 Axis	21
The Emerging Roles of Hydrogen Sulfide in Ferroptosis	20
Disturbance of Hypoxia Response and Its Implications in Kidney Diseases	20
Redox Signaling and Stress in Inherited Myopathies	20
Epigenetic Remodeling in Obesity-Related Vascular Disease	20
Circadian Redox Rhythm in Plant–Fungal Pathogen Interactions	20
Response to Verd and Verd Re: “COVID-19: A Redox Disease—What a Stress Pandemic Can Teach Us About Resilience and What We May Learn from the Reactive Species Interactome About Its Treatment”	20
Rosalind Franklin Society Proudly Announces the 2022 Award Recipient for Antioxidants & Redox Signaling	19
The Landscape of Coding and Noncoding RNAs in Platelets	19
Drug Discovery for Adult Cardiomyocyte Regeneration: Opportunities and Challenges	19
Nrf2-Dependent Adaptation to Oxidative Stress Protects Against Progression of Diabetic Nephropathy	19
Type 1 Diabetes and Associated Cardiovascular Damage: Contribution of Extracellular Vesicles in Tissue Crosstalk	19
The BET Protein Inhibitor Apabetalone Rescues Diabetes-Induced Impairment of Angiogenic Response by Epigenetic Regulation of Thrombospondin-1	19
Stromal Vascular Fraction Restores Vasodilatory Function by Reducing Oxidative Stress in Aging-Induced Coronary Microvascular Disease	19
The Odds of Protein Translation Control Under Stress	19
Pathological Impact of Redox Post-Translational Modifications	18
Impact of Acute and Chronic Psychosocial Stress on Vascular Inflammation	18
New Insights into Herb-Induced Liver Injury	18
Targeting Mitochondrial Oxidative Stress to Protect Against Preterm Birth and Fetal Brain Injury via Nrf2 Induction	18
Enduring Reactive Oxygen Species Emission Causes Aberrant Protein S-Glutathionylation Transitioning Human Aortic Valve Cells from a Sclerotic to a Stenotic Phenotype	18
The Role of Mitochondrial and Redox Alterations in the Skeletal Myopathy Associated with Chronic Kidney Disease	18
Modulation of Protein Disulfide Isomerase Functions by Localization: The Example of the Anterior Gradient Family	18
Correction to: Emerging Chemical Biology of Protein Persulfidation by Vignane and Filipovic. Antioxid Redox Signal 2023;39(1–3):19–39. DOI: 10.1089/ars.2023.0352	18
Reactive Oxygen Species and Their Consequences on the Structure and Function of Mammalian Spermatozoa	18
Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging	18
Maternal Administration of Acetaminophen Affects Meiosis Through its Metabolite NAPQI Targeting SIRT7 in Fetal Oocytes	18
Nogo-B Promotes Endoplasmic Reticulum Stress-Mediated Autophagy in Endothelial Cells of Diabetic Nephropathy	18
Redox-Sensitive Mapping of a Mouse Tumor Model Using Sparse Projection Sampling of Electron Paramagnetic Resonance	18
Vascular Redox Signaling, Endothelial Nitric Oxide Synthase Uncoupling, and Endothelial Dysfunction in the Setting of Transportation Noise Exposure or Chronic Treatment with Organic Nitrates	18
Alterations in Mitochondrial Function in Pulmonary Vascular Diseases	18
Hydrogen Sulfide and Functional Therapy: Novel Mechanisms from Epigenetics	17
Roles of Protein S-Nitrosylation in Endothelial Homeostasis and Dysfunction	17
NRF2: New Mechanistic Insights and Therapeutic Perspectives	17
Peroxiredoxin-4 and Dopamine D5 Receptor Interact to Reduce Oxidative Stress and Inflammation in the Kidney	17
Contribution of Mitochondria to Insulin Secretion by Various Secretagogues	17
Redox Regulatory Changes of Circadian Rhythm by the Environmental Risk Factors Traffic Noise and Air Pollution	17
Biological Sex As a Critical Variable in CD4⁺Effector T Cell Function in Preclinical Models of Multiple Sclerosis	17
Nuclear Factor Erythroid 2-Related Factor 2 and Its Targets in Skeletal Muscle Repair and Regeneration	17
Protein Transnitrosylation Signaling Networks Contribute to Inflammaging and Neurodegenerative Disorders	17
Brain Areas Involved in Modulating the Immune Response Participating in Hypertension and Its Target Organ Damage	17
Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma	17
The Emerging Role of Herbal Medicines in Cancer by Interfering with Posttranslational Modifications	17
Translational Aspects of the Mammalian Target of Rapamycin Complexes in Diabetic Nephropathy	17
Functions of Peroxiredoxins and Their Roles in Autoimmune Diseases	17
mTOR-AKT Signaling in Cellular Clock Resetting Triggered by Osmotic Stress	17
Connexin32 Promotes the Activation of Foxo3a to Ameliorate Diabetic Nephropathy via Inhibiting the Polyubiquitination and Degradation of Sirt1	16
Oxidative Post-Translational Modifications: A Focus on Cysteine S-Sulfhydration and the Regulation of Endothelial Fitness	16
Modulation of Innate Immune Memory Dynamics by Subcellular Reactive Oxygen Species	16
Endothelial Reactive Oxygen Species: Key Players in Cardiovascular Health and Disease	16
Alzheimer's Disease: A Review of Pathology, Current Treatments, and the Potential Therapeutic Effect of Decreasing Oxidative Stress by Combined Vitamin D and l-Cysteine Supplementation	16
KRIT1: A Traffic Warden at the Busy Crossroads Between Redox Signaling and the Pathogenesis of Cerebral Cavernous Malformation Disease	16
Janus, or the Inevitable Battle Between Too Much and Too Little Oxygen	16
Mitochondrial-Derived Signaling Mediates Differentiation of Parietal Epithelial Cells into Podocytes	16
Succinate Activates Uncoupling Protein 2 to Suppress Neuroinflammation and Confer Protection Following Intracerebral Hemorrhage	15
Role of Excessive Mitochondrial Fission in Seawater Immersion Aggravated Hemorrhagic Shock–Induced Cardiac Dysfunction and the Protective Effect of Mitochondrial Division Inhibitor-1	15
Glioblastoma Invasiveness and Collagen Secretion Are Enhanced by Vitamin C	15
Pleiotropic Regulation of PGC-1α in Tumor Initiation and Progression	15
Mitochondria-Targeted Hydrogen Sulfide Delivery Molecules Protect Against UVA-Induced Photoaging in Human Dermal Fibroblasts, and in Mouse Skin In Vivo	15
Hydrogen Sulfide and the Kidney: Physiological Roles, Contribution to Pathophysiology, and Therapeutic Potential	15
Targeting Neuroimmune Interactions in Diabetic Neuropathy with Nanomedicine	15
The Role of Oxidants in Percutaneous Coronary Intervention-Induced Endothelial Dysfunction: Can We Harness Redox Signaling to Improve Clinical Outcomes?	15