OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Immunology is 92. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19	998
The T cell immune response against SARS-CoV-2	809
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function	733
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation	579
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19	541
Single-cell landscape of immunological responses in patients with COVID-19	499
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection	488
Immunogenic cell stress and death	474
NLRP3 inflammasome in cancer and metabolic diseases	463
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition	451
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies	438
Pathological sequelae of long-haul COVID	408
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison	382
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum	380
Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection	377
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion	376
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines	370
Innate immunity: the first line of defense against SARS-CoV-2	328
The immunology of rheumatoid arthritis	311
Autoimmunity and organ damage in systemic lupus erythematosus	301
Trained immunity, tolerance, priming and differentiation: distinct immunological processes	293
Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection	280
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion	263
The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies	252
Extracellular vesicles in immunomodulation and tumor progression	248

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen	239
Microglia use TAM receptors to detect and engulf amyloid β plaques	234
Hallmarks of T cell aging	229
Proinflammatory IgG Fc structures in patients with severe COVID-19	228
The complex role of tumor-infiltrating macrophages	225
Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons	223
Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy	221
Mapping systemic lupus erythematosus heterogeneity at the single-cell level	219
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance	204
Redox homeostasis maintained by GPX4 facilitates STING activation	199
ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection	198
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity	197
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine	193
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines	192
Novel Hexb-based tools for studying microglia in the CNS	187
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms	183
Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity	177
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor	173
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells	170
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans	169
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis	167
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity	167
The mesenchymal context in inflammation, immunity and cancer	166
Early precursor T cells establish and propagate T cell exhaustion in chronic infection	159
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells	156
Environmental pollutants and the immune response	155
Establishment of an African green monkey model for COVID-19 and protection against re-infection	150
A new neutrophil subset promotes CNS neuron survival and axon regeneration	143
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection	143
Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity	140
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans	132
Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis	130
Regulation and modulation of antitumor immunity in pancreatic cancer	128
Dynamics in protein translation sustaining T cell preparedness	127
Inflammasomes and adaptive immune responses	125
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity	122
Does tissue imprinting restrict macrophage plasticity?	121
Neuroinflammation after surgery: from mechanisms to therapeutic targets	118
Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity	117
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression	116
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation	116
Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation	116
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes	116
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells	115
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation	114
Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells	113
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung	113
Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses	113
The immunoregulatory landscape of human tuberculosis granulomas	113
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease	111

The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape	110
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells	109
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection	109
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis	108
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens	106
Immunology of SARS-CoV-2 infection in children	105
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments	105
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity	104
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma	101
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules	101
The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development	100
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects	99
The commensal skin microbiota triggers type I IFN–dependent innate repair responses in injured skin	98
Immune cell compartmentalization for brain surveillance and protection	97
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection	97
Repositioning TH cell polarization from single cytokines to complex help	97
Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19	96