Nature Immunology

Article	Citations
Vaccine-induced memory	1045
Pathogenic T cells in post-viral lung disease in mice	866
The delivery device of SARS-CoV-2 mucosal vaccine matters	718
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	535
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	499
Charting granulopoietic disturbances in sepsis	468
Ironman training for NK cells	375
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	371
Complement profile	333
Imprinting tissue immunity	329
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	305
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	264
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	236
Keeping neonatal intestines happy	210
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	195
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	183
A TNIP1-driven systemic autoimmune disorder with elevated IgG4	179
The complexity of immune evasion mechanisms throughout the metastatic cascade	174
Lactation-associated macrophages exist in murine mammary tissue and human milk	173
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	173
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	173
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	171
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection	165
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	162
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat	160

Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	153
CTLA-4 tail fusion enhances CAR-T antitumor immunity	152
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	151
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	151
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	150
Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	147
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	146
GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity	143
Defective fibrinolysis in periodontitis	141
KEAP1 maintains stemness	138
Reversing T cell immunity reveals the basis for T cell lineage fate determination	138
Nociceptors enhance humoral immunity	137
Restriction factor	136
A polarizing answer — microglia in Nasu-Hakola disease	135
The road not taken en route to T cell exhaustion	134
A microbial iron fist to fight tumors	134
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	134
Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	133
Enhancing T cell therapy	132
Insights into autoimmunity and cancer	132
m1A tRNA modification facilitates rapid T cell proliferation	130
Aging lymph node responses	128
Learning from inborn errors	128
CAR macrophages on a fast track to solid tumor therapy	127
The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting	125
G-CSF drives autoinflammation in APLAID	125
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens	125
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants	125
Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration	123
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity	123
JAK-STAT signaling maintains homeostasis in T cells and macrophages	122
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19	121
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation	119
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines	118
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	117
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	117
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis	114
Aging disrupts circadian gene regulation and function in macrophages	110
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells	110
Defining macrophages in the lactating murine mammary gland and human milk	108
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis	108
Mucus needs GSDMD	107
Distinct developmental pathways generate functionally distinct populations of natural killer cells	105
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells	105
What Jane Jacobs has taught me about neuroimmunology	104
Three cytokine pairs modulate sepsis effects at the organism level	104
Less BMI-1 is more for chronic infections	100
Role of the T cell vitamin D receptor in severe COVID-19	99
Reply to ‘Comment on: Repositioning TH cell polarization from single cytokines to complex help’	93
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms	92

Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors	92
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders	92
Transcriptional state and function of CD8+ memory T cells is linked to past proliferation	92
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice	91
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection	88
Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	88
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation	85
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity	85
Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection	85
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature	85
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers	84
Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis	84
Low-avidity T cells drive endogenous tumor immunity in mice and humans	84
Mapping the interferon response	83
Meningeal damage repair	83
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	83
Mouse long-lived plasma cells develop from multiple origins	81
HSCs perpetuate inflammation	81
Unraveling age-specific complexity in the human T cell compartment	81
Pregnancy stress	80
Gasdermin splicing	79
Facilitating broad antibody responses	79
Itaconate modifies JAK1	77
B cells require exosomes	77
Mentorship matters	76
Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern	75
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73	75
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs	74
Monocyte-derived macrophages are too much of a good thing in lung fibrosis	74
Germinal centers FAMished without TFAM	74
Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network	74
Neuropilin-1 flags lung-resident type 2 innate lymphoid cells	73
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway	73
Diversity in science requires mentoring for all, by all	73
COQ6 defies immune and metabolic expectations	73
Specialization determines outcomes in inflammation and cancer	72
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses	71
Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity	70
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions	69
Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis	69
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory	68
c-Myb redefines the hierarchy of stem-like T cells	68
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus	68
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology	68
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	67
Significance of bystander T cell activation in microbial infection	66
Multitier mechanics control stromal adaptations in the swelling lymph node	66
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection	66
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis	66
Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8+ T cells	66
The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity	65
Gut Treg cells release IL-27 to regulate TH17 cell responses	65
Notch gives early T cell progenitors time to grow up	64
A second-generation M1-polarized CAR macrophage with antitumor efficacy	64
COVID-19 vaccine trials must include helminth-infected cohorts	63
Inflammasome protein scaffolds the DNA damage complex during tumor development	63
Human SHARPIN deficiency is linked to inborn errors of cell death	63
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis	63
Stress-induced inflammation	62
lnc(RNA)-ing myeloid metabolism	62
Monocytes can proliferate in vacant niches before differentiation into macrophages	62
Brain hematopoiesis	61
Anti-tumor CTLs need IL-27	60
γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors	60
Recycling dead bacteria to fuel macrophage immunometabolism	60
TFH cell responses endure in human lymph nodes after vaccination	59
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development	59
m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner	57
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses	57
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19	57
An updated guide for the perplexed: cytometry in the high-dimensional era	57
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19	57
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling	57
The cellular architecture of the antimicrobial response network in human leprosy granulomas	56
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia	56
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	56
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer	56
Author Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	56
Time is of the essence for vaccine success	55
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections	54

The immunoregulatory landscape of human tuberculosis granulomas	54
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition	54
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	54
Insulin signaling establishes a developmental trajectory of adipose regulatory T cells	54
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division	54
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus	54
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	53
Old and new mpox vaccine	53
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease	53
Frank W. Fitch (1929–2021)	53
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity	53
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell	52
PD-L1 senses fungi	52
Inflammatory fibroblasts remodeling in colitis	52
Systems neuroimmunology: current bottlenecks, research priorities and future directions	52
Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation	52
Author Correction: Elusive early NK cell progenitor identified	52
A CRISPR-based system for temporal, combinatorial gene knockout in mice	51
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy	51
PD-1 blockade unblocks immune responses to vaccination	51
The hidden functional diversity of macrophages	51
Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	51
cGAS meets its demise in the nucleus	50
Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1	50
Publisher Correction: IFNγ binding to extracellular matrix prevents fatal systemic toxicity	50
Reactivating antitumor immunity by inhibiting JMJD1C	49
The embers underneath the CoV-2 pandemic: a semblance of the persistent burn of health inequities and disparities in the United States	49
Advancements in pathogen immunity and signaling	49
IFNλ drives diarrhea	49
ImmGenMaps, an open-source cartography of the immune system	48
Unveiling the antitumor function of ID3 in liver macrophages	48
Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations	48
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules	48
Short-range immunity	48
Skin–gut crosstalk	48
An anion channel for cyclic dinucleotides in T cells	47
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses	47
Macrophage niche availability enables local monocyte proliferation in peripheral tissues	47
Thioredoxin is a metabolic rheostat controlling regulatory B cells	47
The humoral response and antibodies against SARS-CoV-2 infection	46
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity	46
Mechanism for controlled assembly of transcriptional condensates by Aire	46
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development	46
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells	46
TH17 cell heterogeneity and its role in tissue inflammation	45
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	45
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease	45
TCF-1 mediates chromatin intermingling during T cell development	44
Stress and immunity — the circuit makes the difference	44
Mitochondria controls TH17 cells	44
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	44
Check(point) yourself before you wreck yourself in tumors	43
Natural mouse microbes transiently block innate responses to allergens	43
Two CTLA-4 ligands, separate pHates	43
High energy, high function	43
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	42
Stuart Schlossman (1935–2023)	42
Plasmacytoid dendritic cells turn red!	42
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19	41
Modulating RNF41	41
IL-1α in aging tumors	41
SLE B cells take an extrafollicular detour after mRNA vaccination	41
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	40
Past interactions of T cells with antigens shape CAR T cell responses	40
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases	39
OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity	39
Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs	39
T cells drive aging of the brain	38
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells	38
Macrophages and fibroblasts as regulators of the immune response in pancreatic cancer	38
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse	37
Innate immune cells link dietary cues to normal and abnormal metabolic regulation	37
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression	36
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling	36
Intestinal neuron-associated macrophages in health and disease	36
Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion	36
VDAC2 enforces a mitochondrial checkpoint to cancer immunity	36
Innate lymphoid cells and cancer	35
A protective ACPA	35
Reactivity to type I interferon is key to predict cancer immunotherapy response	35
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	35
Macrophages set the bar for acute pain sensitivity	35
Immunological imprinting and risks of influenza B virus infection	35
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	35
Distinct metabolic requirements regulate B cell activation and germinal center responses	35
Common heritage of fibroblasts	35
Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa	34
Metabolite signaling promotes the recruitment of immunosuppressive cells to tumors	34
Author Correction: Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota	34
Long COVID	34
Controlling TRM differentiation	34
Hidden in plain sight: uncovering the role of CREB1 in HIV-1 vaccine-induced immunity	34
Author Correction: Human circulating and tissue-resident memory CD8+ T cells	33
A balancing act in the control of self-antigen expression	33
Tracing the origins of lung fibrosis	33