Nature Immunology

Article	Citations
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19	998
The T cell immune response against SARS-CoV-2	809
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function	733
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation	579
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19	541
Single-cell landscape of immunological responses in patients with COVID-19	499
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection	488
Immunogenic cell stress and death	474
NLRP3 inflammasome in cancer and metabolic diseases	463
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition	451
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies	438
Pathological sequelae of long-haul COVID	408
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison	382
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum	380
Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection	377
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion	376
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines	370
Innate immunity: the first line of defense against SARS-CoV-2	328
The immunology of rheumatoid arthritis	311
Autoimmunity and organ damage in systemic lupus erythematosus	301
Trained immunity, tolerance, priming and differentiation: distinct immunological processes	293
Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection	280
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion	263
The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies	252
Extracellular vesicles in immunomodulation and tumor progression	248

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen	239
Microglia use TAM receptors to detect and engulf amyloid β plaques	234
Hallmarks of T cell aging	229
Proinflammatory IgG Fc structures in patients with severe COVID-19	228
The complex role of tumor-infiltrating macrophages	225
Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons	223
Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy	221
Mapping systemic lupus erythematosus heterogeneity at the single-cell level	219
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance	204
Redox homeostasis maintained by GPX4 facilitates STING activation	199
ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection	198
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity	197
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine	193
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines	192
Novel Hexb-based tools for studying microglia in the CNS	187
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms	183
Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity	177
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor	173
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells	170
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans	169
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity	167
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis	167
The mesenchymal context in inflammation, immunity and cancer	166
Early precursor T cells establish and propagate T cell exhaustion in chronic infection	159
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells	156
Environmental pollutants and the immune response	155
Establishment of an African green monkey model for COVID-19 and protection against re-infection	150
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection	143
A new neutrophil subset promotes CNS neuron survival and axon regeneration	143
Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity	140
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans	132
Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis	130
Regulation and modulation of antitumor immunity in pancreatic cancer	128
Dynamics in protein translation sustaining T cell preparedness	127
Inflammasomes and adaptive immune responses	125
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity	122
Does tissue imprinting restrict macrophage plasticity?	121
Neuroinflammation after surgery: from mechanisms to therapeutic targets	118
Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity	117
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes	116
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression	116
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation	116
Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation	116
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells	115
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation	114
The immunoregulatory landscape of human tuberculosis granulomas	113
Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells	113
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung	113
Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses	113
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease	111

The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape	110
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells	109
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection	109
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis	108
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens	106
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments	105
Immunology of SARS-CoV-2 infection in children	105
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity	104
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules	101
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma	101
The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development	100
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects	99
The commensal skin microbiota triggers type I IFN–dependent innate repair responses in injured skin	98
Repositioning TH cell polarization from single cytokines to complex help	97
Immune cell compartmentalization for brain surveillance and protection	97
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection	97
Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19	96
Epigenetic regulation of T cell exhaustion	90
The humoral response and antibodies against SARS-CoV-2 infection	89
Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis	89
Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments	88
Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity	87
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection	87
Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression	86
Inefficient CAR-proximal signaling blunts antigen sensitivity	85
STEEP mediates STING ER exit and activation of signaling	84
Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits	84
BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection	84
Distinct transcription factor networks control neutrophil-driven inflammation	84
Innate lymphoid cells and cancer	83
Delayed-interval BNT162b2 mRNA COVID-19 vaccination enhances humoral immunity and induces robust T cell responses	81
Remodeling of light and dark zone follicular dendritic cells governs germinal center responses	81
Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states	80
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells	78
Lessons learned: new insights on the role of cytokines in COVID-19	77
BATF3 programs CD8+ T cell memory	76
PERK is a critical metabolic hub for immunosuppressive function in macrophages	76
Transmission of trained immunity and heterologous resistance to infections across generations	76
Peripherally induced brain tissue–resident memory CD8+ T cells mediate protection against CNS infection	74
Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin	74
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals	73
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19	72
Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity	72
The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge	72
Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors	71
Human immune diversity: from evolution to modernity	71
Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria	69
Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function	68
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	68
IRGM1 links mitochondrial quality control to autoimmunity	68
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	67
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics	67
Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation	67
Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells	67
The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate	67
Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung	66
A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma	66
Aging disrupts circadian gene regulation and function in macrophages	66
Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands	65
Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes	64
Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation	64
Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy	63
Superior immunogenicity and effectiveness of the third compared to the second BNT162b2 vaccine dose	63
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory	63
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	63
Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues	62
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation	62
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins	62
Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity	62
Significance of bystander T cell activation in microbial infection	62
IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation	61
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses	60
Functional CRISPR dissection of gene networks controlling human regulatory T cell identity	59
Heme catabolism by tumor-associated macrophages controls metastasis formation	59
Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity	59
Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication	59
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	59
Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques	59
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells	58
The cellular architecture of the antimicrobial response network in human leprosy granulomas	58

Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress	58
LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation	57
Naturalizing mouse models for immunology	57
Fibroblasts as a source of self-antigens for central immune tolerance	57
The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic–epigenetic reprogramming and resolves inflammatory injury	57
T cells in COVID-19 — united in diversity	56
Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease	55
NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting	55
The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection	54
Tissue adaptation and clonal segregation of human memory T cells in barrier sites	54
γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis	54
Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition	54
Microbial metabolism of l-tyrosine protects against allergic airway inflammation	53
Divergent clonal differentiation trajectories of T cell exhaustion	53
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity	53
RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus	53
ImmGen at 15	52
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat	50
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets	50
Clonal expansion and epigenetic inheritance of long-lasting NK cell memory	50
Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses	50
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B	50
Making innate sense of mRNA vaccine adjuvanticity	49
Circadian clocks guide dendritic cells into skin lymphatics	49
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection	49
mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates	48
The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING–IFN-β pathway	48
Chd4 choreographs self-antigen expression for central immune tolerance	48
Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion	47
Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis	47
SARS-CoV-2 takes its Toll	47
Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity	47
Surface phenotypes of naive and memory B cells in mouse and human tissues	47
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity	47
Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues	46
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation	46
Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells	46
Distinct changes in endosomal composition promote NLRP3 inflammasome activation	46
Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies	45
Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses	45
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	45
TH17 cell heterogeneity and its role in tissue inflammation	45
Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome	45
Environmental allergens trigger type 2 inflammation through ripoptosome activation	45
The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis	44
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling	44
Dynamic regulation of B cell complement signaling is integral to germinal center responses	44
CD4+ T cell memory	44
TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer	43
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses	43
An updated guide for the perplexed: cytometry in the high-dimensional era	43
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	43
Insulin signaling establishes a developmental trajectory of adipose regulatory T cells	43
Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory	43
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	42
Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development	42
Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development	42
Wnt–β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression	41
An engineered bispecific human monoclonal antibody against SARS-CoV-2	40
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory	40
Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer	40
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection	40
SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)	40
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course	40
Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations	40
BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S2	40
Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis	40
Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells	39
Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota	39
Neutrophils direct preexisting matrix to initiate repair in damaged tissues	39
Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs	39
Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis	39
Early emergence of T central memory precursors programs clonal dominance during chronic viral infection	39
Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes	39
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19	38
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	38
High-throughput and high-dimensional single-cell analysis of antigen-specific CD8+ T cells	38
TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis	38
Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation	38
Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation	38
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity	37
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3	37
Taiwan’s experience in fighting COVID-19	37
YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8+ T cells	37
Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate	37
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer	37
CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	36
Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis	36
Molecular mechanisms of gasdermin D pore-forming activity	36
A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections	36
Clonal structure, stability and dynamics of human memory B cells and circulating plasmablasts	36
Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity	35
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity	35
In situ neutrophil efferocytosis shapes T cell immunity to influenza infection	35
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity	35