Nature Immunology

Article	Citations
Vaccine-induced memory	1088
The delivery device of SARS-CoV-2 mucosal vaccine matters	973
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	754
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	583
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	550
Complement profile	502
Imprinting tissue immunity	481
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	413
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	366
Keeping neonatal intestines happy	365
Astrocyte TRAIL promotes GBM	239
Neurons protect against fibrosis	221
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	208
Pathogenic T cells in post-viral lung disease in mice	202
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	198
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	198
Ironman training for NK cells	194
Charting granulopoietic disturbances in sepsis	183
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	183
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	179
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection	179
CTLA-4 tail fusion enhances CAR-T antitumor immunity	178
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	172
A TNIP1-driven systemic autoimmune disorder with elevated IgG4	167
The complexity of immune evasion mechanisms throughout the metastatic cascade	166

Lactation-associated macrophages exist in murine mammary tissue and human milk	163
Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	159
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	159
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat	159
Secretogranin 2 binds LILRB4 resulting in immunosuppression	157
A little less reading, a little more type 9 action	155
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	150
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	149
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	149
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	148
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	148
Defective fibrinolysis in periodontitis	147
Reversing T cell immunity reveals the basis for T cell lineage fate determination	146
Nociceptors enhance humoral immunity	145
Restriction factor	145
Beneficial role of GZMK+CD8+ T cells in neurodegeneration	142
A polarizing answer — microglia in Nasu-Hakola disease	142
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity	138
Microglia loss triggers glial stress and white matter damage in human leukodystrophy	138
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis	138
CAR macrophages on a fast track to solid tumor therapy	137
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity	135
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis	135
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	135
A microbial iron fist to fight tumors	134
The road not taken en route to T cell exhaustion	132
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	127
Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	126
Insights into autoimmunity and cancer	125
Enhancing T cell therapy	125
m1A tRNA modification facilitates rapid T cell proliferation	122
Learning from inborn errors	117
G-CSF drives autoinflammation in APLAID	115
Aging lymph node responses	115
Carboxylation switch	114
Six degrees of TGFβ	113
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis	110
Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration	109
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19	107
Aging disrupts circadian gene regulation and function in macrophages	106
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation	106
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens	105
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells	105
KEAP1 maintains stemness	104
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription	99
JAK-STAT signaling maintains homeostasis in T cells and macrophages	98
GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity	98
Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt	98
The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting	97
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	96

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants	96
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines	96
Defining macrophages in the lactating murine mammary gland and human milk	95
Mucus needs GSDMD	93
What Jane Jacobs has taught me about neuroimmunology	92
Three cytokine pairs modulate sepsis effects at the organism level	90
Role of the T cell vitamin D receptor in severe COVID-19	89
Less BMI-1 is more for chronic infections	89
Reply to ‘Comment on: Repositioning TH cell polarization from single cytokines to complex help’	88
Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors	87
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms	87
Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	86
Transcriptional state and function of CD8+ memory T cells is linked to past proliferation	84
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice	83
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers	83
Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection	82
Distinct developmental pathways generate functionally distinct populations of natural killer cells	81
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection	80
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders	80
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	79
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation	79
2B or not 2B is the question in DC ontogeny	79
Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis	78
LPS structure shapes Treg cells	78
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets	78
Low-avidity T cells drive endogenous tumor immunity in mice and humans	77
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature	77
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells	76
Meningeal damage repair	76
Unraveling age-specific complexity in the human T cell compartment	76
Mapping the interferon response	76
HSCs perpetuate inflammation	75
Mouse long-lived plasma cells develop from multiple origins	75
Facilitating broad antibody responses	73
Pregnancy stress	73
B cells require exosomes	72
Gasdermin splicing	72
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73	71
Germinal centers FAMished without TFAM	70
Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern	70
Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network	69
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway	68
COQ6 defies immune and metabolic expectations	68
Neuropilin-1 flags lung-resident type 2 innate lymphoid cells	68
Monocyte-derived macrophages are too much of a good thing in lung fibrosis	68
Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis	66
Gut Treg cells release IL-27 to regulate TH17 cell responses	66
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions	66
Specialization determines outcomes in inflammation and cancer	65
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs	64
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	64
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis	63
Itaconate modifies JAK1	63
c-Myb redefines the hierarchy of stem-like T cells	62
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus	62
Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity	62
Multitier mechanics control stromal adaptations in the swelling lymph node	61
The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer	61
Notch gives early T cell progenitors time to grow up	61
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection	61
A second-generation M1-polarized CAR macrophage with antitumor efficacy	61
The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity	61
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory	61
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses	61
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology	61
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis	60
Human SHARPIN deficiency is linked to inborn errors of cell death	60
Anti-tumor CTLs need IL-27	59
lnc(RNA)-ing myeloid metabolism	59
Towards evidence-based immunology	59
Monocytes can proliferate in vacant niches before differentiation into macrophages	59
Y do T cells fail	59
γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors	58
Recycling dead bacteria to fuel macrophage immunometabolism	57
Inflammasome protein scaffolds the DNA damage complex during tumor development	57
TFH cell responses endure in human lymph nodes after vaccination	56
Time is of the essence for vaccine success	56
An updated guide for the perplexed: cytometry in the high-dimensional era	56
Author Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	56
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling	56

m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner	56
Stress-induced inflammation	56
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19	56
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity	55
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition	55
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease	55
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses	54
Antiphage SIR2 in humans	54
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections	54
The immunoregulatory landscape of human tuberculosis granulomas	53
Humanized mice for MS studies	53
TNF gives plasmacytoid dendritic cells a new life	53
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19	52
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer	52
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia	52
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus	51
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	51
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development	51
COVID-19 vaccine trials must include helminth-infected cohorts	51
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division	51
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	50
Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation	50
Old and new mpox vaccine	50
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy	49
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell	49
PD-L1 senses fungi	49
Inflammatory fibroblasts remodeling in colitis	49
Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	49
Author Correction: Elusive early NK cell progenitor identified	49
Publisher Correction: IFNγ binding to extracellular matrix prevents fatal systemic toxicity	48
PD-1 blockade unblocks immune responses to vaccination	48
cGAS meets its demise in the nucleus	48
Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1	48
IFNλ drives diarrhea	47
Reactivating antitumor immunity by inhibiting JMJD1C	47
The embers underneath the CoV-2 pandemic: a semblance of the persistent burn of health inequities and disparities in the United States	47
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development	47
Advancements in pathogen immunity and signaling	47
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells	46
The BCR-SEQC initiative	46
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	46
Short-range immunity	46
Mechanism for controlled assembly of transcriptional condensates by Aire	46
Unveiling the antitumor function of ID3 in liver macrophages	45
Skin–gut crosstalk	45
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules	45
ImmGenMaps, an open-source cartography of the immune system	45
An anion channel for cyclic dinucleotides in T cells	44
A CRISPR-based system for temporal, combinatorial gene knockout in mice	44
The hidden functional diversity of macrophages	43
Systems neuroimmunology: current bottlenecks, research priorities and future directions	43
Stress and immunity — the circuit makes the difference	43
Spatial map of microglial diversity beyond proteopathy	43
Macrophage niche availability enables local monocyte proliferation in peripheral tissues	43
Thioredoxin is a metabolic rheostat controlling regulatory B cells	42
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease	42
Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations	42
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity	42
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses	41
The humoral response and antibodies against SARS-CoV-2 infection	41
TH17 cell heterogeneity and its role in tissue inflammation	41
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	41
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	40
Mitochondria controls TH17 cells	40
TCF-1 mediates chromatin intermingling during T cell development	40
Check(point) yourself before you wreck yourself in tumors	39
Natural mouse microbes transiently block innate responses to allergens	39
Two CTLA-4 ligands, separate pHates	39
High energy, high function	39
Stuart Schlossman (1935–2023)	38
SLE B cells take an extrafollicular detour after mRNA vaccination	38
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	38
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19	38
IL-1α in aging tumors	38
Plasmacytoid dendritic cells turn red!	38
Modulating RNF41	38
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	38
Past interactions of T cells with antigens shape CAR T cell responses	37
Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion	37
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	37
VDAC2 enforces a mitochondrial checkpoint to cancer immunity	37
T cells drive aging of the brain	36
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells	36
LARP4-mediated hypertranslation drives T cell dysfunction in tumors	36
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling	36
OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity	36
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse	36
Intestinal neuron-associated macrophages in health and disease	36
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	36
Innate immune cells link dietary cues to normal and abnormal metabolic regulation	36
Macrophages and fibroblasts as regulators of the immune response in pancreatic cancer	36
Innate lymphoid cells and cancer	36
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases	35
Distinct metabolic requirements regulate B cell activation and germinal center responses	35
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression	35