Nature Immunology

Article	Citations
Vaccine-induced memory	1062
Pathogenic T cells in post-viral lung disease in mice	905
The delivery device of SARS-CoV-2 mucosal vaccine matters	729
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	539
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	523
Charting granulopoietic disturbances in sepsis	478
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	412
Complement profile	380
Imprinting tissue immunity	345
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	342
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	316
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	273
Ironman training for NK cells	237
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	215
CTLA-4 tail fusion enhances CAR-T antitumor immunity	203
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	187
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	185
Keeping neonatal intestines happy	184
Astrocyte TRAIL promotes GBM	178
A TNIP1-driven systemic autoimmune disorder with elevated IgG4	176
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	175
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	172
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	169
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat	167
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	165

PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection	159
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	158
Lactation-associated macrophages exist in murine mammary tissue and human milk	158
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	157
The complexity of immune evasion mechanisms throughout the metastatic cascade	157
Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	151
Neurons protect against fibrosis	149
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	149
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	144
GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity	142
Defective fibrinolysis in periodontitis	142
KEAP1 maintains stemness	141
Reversing T cell immunity reveals the basis for T cell lineage fate determination	140
Restriction factor	138
Nociceptors enhance humoral immunity	138
A polarizing answer — microglia in Nasu-Hakola disease	137
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	136
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis	135
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19	134
The road not taken en route to T cell exhaustion	134
A microbial iron fist to fight tumors	134
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	133
Insights into autoimmunity and cancer	131
Enhancing T cell therapy	131
Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	131
m1A tRNA modification facilitates rapid T cell proliferation	131
Aging lymph node responses	130
Learning from inborn errors	130
G-CSF drives autoinflammation in APLAID	129
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens	129
Aging disrupts circadian gene regulation and function in macrophages	128
CAR macrophages on a fast track to solid tumor therapy	125
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity	123
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants	122
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	117
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis	116
Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration	115
The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting	114
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity	113
Beneficial role of GZMK+CD8+ T cells in neurodegeneration	112
Microglia loss triggers glial stress and white matter damage in human leukodystrophy	109
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells	109
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines	108
JAK-STAT signaling maintains homeostasis in T cells and macrophages	106
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation	104
Mucus needs GSDMD	101
Defining macrophages in the lactating murine mammary gland and human milk	101
What Jane Jacobs has taught me about neuroimmunology	99
Three cytokine pairs modulate sepsis effects at the organism level	98
Less BMI-1 is more for chronic infections	95

Reply to ‘Comment on: Repositioning TH cell polarization from single cytokines to complex help’	94
Role of the T cell vitamin D receptor in severe COVID-19	94
Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors	93
Transcriptional state and function of CD8+ memory T cells is linked to past proliferation	92
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation	90
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers	90
Distinct developmental pathways generate functionally distinct populations of natural killer cells	90
Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	90
Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection	90
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms	87
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature	87
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection	87
Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis	87
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders	86
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells	85
Low-avidity T cells drive endogenous tumor immunity in mice and humans	85
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice	85
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	83
Meningeal damage repair	82
Mapping the interferon response	82
Unraveling age-specific complexity in the human T cell compartment	81
Mouse long-lived plasma cells develop from multiple origins	80
HSCs perpetuate inflammation	80
Pregnancy stress	79
Gasdermin splicing	78
Facilitating broad antibody responses	78
B cells require exosomes	78
Itaconate modifies JAK1	77
Mentorship matters	77
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73	76
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs	75
Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern	75
Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network	74
Germinal centers FAMished without TFAM	74
COQ6 defies immune and metabolic expectations	73
Monocyte-derived macrophages are too much of a good thing in lung fibrosis	73
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway	71
Neuropilin-1 flags lung-resident type 2 innate lymphoid cells	70
Diversity in science requires mentoring for all, by all	70
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses	70
Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity	69
Gut Treg cells release IL-27 to regulate TH17 cell responses	68
Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8+ T cells	68
c-Myb redefines the hierarchy of stem-like T cells	68
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions	68
Multitier mechanics control stromal adaptations in the swelling lymph node	67
Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis	67
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection	67
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory	67
Specialization determines outcomes in inflammation and cancer	66
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus	66
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis	66
A second-generation M1-polarized CAR macrophage with antitumor efficacy	65
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	65
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology	65
The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity	65
Significance of bystander T cell activation in microbial infection	64
Notch gives early T cell progenitors time to grow up	63
Human SHARPIN deficiency is linked to inborn errors of cell death	63
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis	62
COVID-19 vaccine trials must include helminth-infected cohorts	62
Inflammasome protein scaffolds the DNA damage complex during tumor development	61
Stress-induced inflammation	60
Brain hematopoiesis	60
lnc(RNA)-ing myeloid metabolism	60
Monocytes can proliferate in vacant niches before differentiation into macrophages	60
Anti-tumor CTLs need IL-27	59
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia	58
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses	58
Recycling dead bacteria to fuel macrophage immunometabolism	58
Author Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	58
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections	57
An updated guide for the perplexed: cytometry in the high-dimensional era	57
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19	57
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus	56
Time is of the essence for vaccine success	56
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer	56
The immunoregulatory landscape of human tuberculosis granulomas	55
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19	55
TFH cell responses endure in human lymph nodes after vaccination	55

γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors	55
m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner	55
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity	55
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling	55
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development	55
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease	54
Towards evidence-based immunology	54
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	54
Y do T cells fail	54
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition	54
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division	54
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	53
Old and new mpox vaccine	52
Insulin signaling establishes a developmental trajectory of adipose regulatory T cells	52
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	52
Author Correction: Elusive early NK cell progenitor identified	51
Inflammatory fibroblasts remodeling in colitis	51
Systems neuroimmunology: current bottlenecks, research priorities and future directions	51
PD-L1 senses fungi	51
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell	51
The hidden functional diversity of macrophages	51
Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation	51
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy	51
PD-1 blockade unblocks immune responses to vaccination	50
Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	50
Publisher Correction: IFNγ binding to extracellular matrix prevents fatal systemic toxicity	50
cGAS meets its demise in the nucleus	49
Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1	49
Reactivating antitumor immunity by inhibiting JMJD1C	49
IFNλ drives diarrhea	48
ImmGenMaps, an open-source cartography of the immune system	48
Advancements in pathogen immunity and signaling	48
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development	48
Skin–gut crosstalk	48
The embers underneath the CoV-2 pandemic: a semblance of the persistent burn of health inequities and disparities in the United States	48
Short-range immunity	48
Macrophage niche availability enables local monocyte proliferation in peripheral tissues	47
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity	47
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules	47
An anion channel for cyclic dinucleotides in T cells	47
Unveiling the antitumor function of ID3 in liver macrophages	47
A CRISPR-based system for temporal, combinatorial gene knockout in mice	46
Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations	46
Mechanism for controlled assembly of transcriptional condensates by Aire	45
Stress and immunity — the circuit makes the difference	45
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease	45
TH17 cell heterogeneity and its role in tissue inflammation	44
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells	44
The humoral response and antibodies against SARS-CoV-2 infection	44
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses	43
The BCR-SEQC initiative	43
Thioredoxin is a metabolic rheostat controlling regulatory B cells	43
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	42
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	42
TCF-1 mediates chromatin intermingling during T cell development	42
Mitochondria controls TH17 cells	41
Check(point) yourself before you wreck yourself in tumors	41
Natural mouse microbes transiently block innate responses to allergens	41
Two CTLA-4 ligands, separate pHates	41
High energy, high function	41
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	40
Stuart Schlossman (1935–2023)	40
Modulating RNF41	40
Plasmacytoid dendritic cells turn red!	40
IL-1α in aging tumors	39
SLE B cells take an extrafollicular detour after mRNA vaccination	39
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	39
Past interactions of T cells with antigens shape CAR T cell responses	38
OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity	38
Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion	38
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	38
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases	38
Macrophages and fibroblasts as regulators of the immune response in pancreatic cancer	37
VDAC2 enforces a mitochondrial checkpoint to cancer immunity	37
Distinct metabolic requirements regulate B cell activation and germinal center responses	37
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse	37
Intestinal neuron-associated macrophages in health and disease	36
Innate lymphoid cells and cancer	36
T cells drive aging of the brain	36
Innate immune cells link dietary cues to normal and abnormal metabolic regulation	36
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells	36
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression	36
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19	36
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling	36
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	36
Author Correction: Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota	35
Controlling TRM differentiation	35
Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs	35
A protective ACPA	35
Common heritage of fibroblasts	35
Long COVID	35
Tracing the origins of lung fibrosis	34
Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa	34
Hidden in plain sight: uncovering the role of CREB1 in HIV-1 vaccine-induced immunity	34
Metabolite signaling promotes the recruitment of immunosuppressive cells to tumors	34