Nature Immunology

Article	Citations
Vaccine-induced memory	1077
The delivery device of SARS-CoV-2 mucosal vaccine matters	943
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	741
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	550
Charting granulopoietic disturbances in sepsis	544
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	494
Complement profile	450
Imprinting tissue immunity	398
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	353
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	352
Keeping neonatal intestines happy	324
Astrocyte TRAIL promotes GBM	277
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	227
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	214
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	201
A TNIP1-driven systemic autoimmune disorder with elevated IgG4	193
CTLA-4 tail fusion enhances CAR-T antitumor immunity	193
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	189
Neurons protect against fibrosis	186
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	177
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	173
The complexity of immune evasion mechanisms throughout the metastatic cascade	171
Secretogranin 2 binds LILRB4 resulting in immunosuppression	169
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	166
Pathogenic T cells in post-viral lung disease in mice	165

Transposon-triggered innate immune response confers cancer resistance to the blind mole rat	165
Lactation-associated macrophages exist in murine mammary tissue and human milk	158
Ironman training for NK cells	156
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	156
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection	153
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	151
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	150
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	150
Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	147
Defective fibrinolysis in periodontitis	145
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	145
KEAP1 maintains stemness	144
Reversing T cell immunity reveals the basis for T cell lineage fate determination	143
Nociceptors enhance humoral immunity	141
A polarizing answer — microglia in Nasu-Hakola disease	141
Restriction factor	141
GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity	140
Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration	140
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity	138
Microglia loss triggers glial stress and white matter damage in human leukodystrophy	137
Beneficial role of GZMK+CD8+ T cells in neurodegeneration	137
A microbial iron fist to fight tumors	135
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis	135
The road not taken en route to T cell exhaustion	134
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	133
Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	132
Enhancing T cell therapy	130
Insights into autoimmunity and cancer	129
m1A tRNA modification facilitates rapid T cell proliferation	128
Aging lymph node responses	125
Learning from inborn errors	125
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	121
G-CSF drives autoinflammation in APLAID	121
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells	118
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity	117
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation	117
Aging disrupts circadian gene regulation and function in macrophages	112
Carboxylation switch	111
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens	110
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	108
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis	107
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19	107
JAK-STAT signaling maintains homeostasis in T cells and macrophages	103
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants	102
Six degrees of TGFβ	101
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis	101
The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting	99
CAR macrophages on a fast track to solid tumor therapy	96
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines	96
Defining macrophages in the lactating murine mammary gland and human milk	95

Mucus needs GSDMD	94
What Jane Jacobs has taught me about neuroimmunology	93
Distinct developmental pathways generate functionally distinct populations of natural killer cells	93
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers	93
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation	93
Three cytokine pairs modulate sepsis effects at the organism level	91
Less BMI-1 is more for chronic infections	90
Role of the T cell vitamin D receptor in severe COVID-19	89
Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors	88
Reply to ‘Comment on: Repositioning TH cell polarization from single cytokines to complex help’	88
Transcriptional state and function of CD8+ memory T cells is linked to past proliferation	87
Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	86
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature	86
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice	85
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders	85
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms	85
Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection	84
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells	84
Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis	82
Low-avidity T cells drive endogenous tumor immunity in mice and humans	81
Meningeal damage repair	79
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	79
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection	79
2B or not 2B is the question in DC ontogeny	79
Unraveling age-specific complexity in the human T cell compartment	78
Mapping the interferon response	78
HSCs perpetuate inflammation	77
Facilitating broad antibody responses	76
Pregnancy stress	76
Mouse long-lived plasma cells develop from multiple origins	76
Gasdermin splicing	75
B cells require exosomes	74
Germinal centers FAMished without TFAM	73
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73	73
Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern	73
Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network	72
Monocyte-derived macrophages are too much of a good thing in lung fibrosis	72
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway	71
COQ6 defies immune and metabolic expectations	71
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection	70
Neuropilin-1 flags lung-resident type 2 innate lymphoid cells	70
Itaconate modifies JAK1	69
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory	69
Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis	68
Specialization determines outcomes in inflammation and cancer	67
Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity	67
c-Myb redefines the hierarchy of stem-like T cells	67
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs	67
Gut Treg cells release IL-27 to regulate TH17 cell responses	67
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology	66
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus	66
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions	66
The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer	65
Significance of bystander T cell activation in microbial infection	65
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses	64
The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity	63
Multitier mechanics control stromal adaptations in the swelling lymph node	63
A second-generation M1-polarized CAR macrophage with antitumor efficacy	62
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis	61
COVID-19 vaccine trials must include helminth-infected cohorts	61
Notch gives early T cell progenitors time to grow up	61
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	61
Human SHARPIN deficiency is linked to inborn errors of cell death	61
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis	60
An updated guide for the perplexed: cytometry in the high-dimensional era	59
lnc(RNA)-ing myeloid metabolism	59
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	59
Monocytes can proliferate in vacant niches before differentiation into macrophages	59
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses	58
m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner	58
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease	58
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity	58
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19	58
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition	58
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	58
Towards evidence-based immunology	57
Anti-tumor CTLs need IL-27	57
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling	56
γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors	56
Y do T cells fail	56

Recycling dead bacteria to fuel macrophage immunometabolism	55
Author Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	55
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus	55
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections	55
Inflammasome protein scaffolds the DNA damage complex during tumor development	55
Stress-induced inflammation	54
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia	54
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development	54
Time is of the essence for vaccine success	54
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19	53
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer	53
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division	53
TFH cell responses endure in human lymph nodes after vaccination	53
Old and new mpox vaccine	52
The immunoregulatory landscape of human tuberculosis granulomas	52
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	52
Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation	52
Insulin signaling establishes a developmental trajectory of adipose regulatory T cells	52
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell	51
Author Correction: Elusive early NK cell progenitor identified	51
Inflammatory fibroblasts remodeling in colitis	51
PD-1 blockade unblocks immune responses to vaccination	50
PD-L1 senses fungi	50
Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1	50
Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	50
Publisher Correction: IFNγ binding to extracellular matrix prevents fatal systemic toxicity	50
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy	50
cGAS meets its demise in the nucleus	49
The embers underneath the CoV-2 pandemic: a semblance of the persistent burn of health inequities and disparities in the United States	49
Reactivating antitumor immunity by inhibiting JMJD1C	49
Advancements in pathogen immunity and signaling	49
ImmGenMaps, an open-source cartography of the immune system	48
Unveiling the antitumor function of ID3 in liver macrophages	48
Short-range immunity	48
Skin–gut crosstalk	48
IFNλ drives diarrhea	48
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules	47
Mechanism for controlled assembly of transcriptional condensates by Aire	46
A CRISPR-based system for temporal, combinatorial gene knockout in mice	46
Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations	46
The BCR-SEQC initiative	46
An anion channel for cyclic dinucleotides in T cells	46
Stress and immunity — the circuit makes the difference	45
The hidden functional diversity of macrophages	45
Macrophage niche availability enables local monocyte proliferation in peripheral tissues	45
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development	44
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease	44
The humoral response and antibodies against SARS-CoV-2 infection	43
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity	43
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells	43
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses	43
Spatial map of microglial diversity beyond proteopathy	43
Thioredoxin is a metabolic rheostat controlling regulatory B cells	42
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	41
TCF-1 mediates chromatin intermingling during T cell development	41
High energy, high function	41
Natural mouse microbes transiently block innate responses to allergens	41
Systems neuroimmunology: current bottlenecks, research priorities and future directions	41
Mitochondria controls TH17 cells	41
Two CTLA-4 ligands, separate pHates	41
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	41
TH17 cell heterogeneity and its role in tissue inflammation	41
Check(point) yourself before you wreck yourself in tumors	41
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	40
Stuart Schlossman (1935–2023)	40
SLE B cells take an extrafollicular detour after mRNA vaccination	40
Plasmacytoid dendritic cells turn red!	40
Modulating RNF41	40
IL-1α in aging tumors	39
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	39
OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity	38
Innate immune cells link dietary cues to normal and abnormal metabolic regulation	38
Past interactions of T cells with antigens shape CAR T cell responses	38
Macrophages and fibroblasts as regulators of the immune response in pancreatic cancer	38
Innate lymphoid cells and cancer	37
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells	37
Intestinal neuron-associated macrophages in health and disease	37
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases	37
Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs	37
T cells drive aging of the brain	37
VDAC2 enforces a mitochondrial checkpoint to cancer immunity	37
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	37
LARP4-mediated hypertranslation drives T cell dysfunction in tumors	36
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression	36
Distinct metabolic requirements regulate B cell activation and germinal center responses	36
Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion	36
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse	36
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	36
Controlling TRM differentiation	35
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19	35
A protective ACPA	35
Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa	35
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling	35
Macrophages set the bar for acute pain sensitivity	34
Dosage compensation in T cells	34