Nature Immunology

Article	Citations
Vaccine-induced memory	1131
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	1094
Ironman training for NK cells	806
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	657
Keeping neonatal intestines happy	580
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	573
Imprinting tissue immunity	528
Complement profile	463
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	414
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	405
TFH cell programs by pathogen and species	269
A little less reading, a little more type 9 action	249
Pathogenic T cells in post-viral lung disease in mice	242
Neurons protect against fibrosis	240
Secretogranin 2 binds LILRB4 resulting in immunosuppression	234
Astrocyte TRAIL promotes GBM	234
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	233
A TNIP1-driven systemic autoimmune disorder with elevated IgG4	226
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	215
The delivery device of SARS-CoV-2 mucosal vaccine matters	210
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	205
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	202
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection	201
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	194
The complexity of immune evasion mechanisms throughout the metastatic cascade	191

Charting granulopoietic disturbances in sepsis	186
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	183
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	182
Lactation-associated macrophages exist in murine mammary tissue and human milk	180
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	180
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	180
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	178
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	178
CTLA-4 tail fusion enhances CAR-T antitumor immunity	176
Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	174
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	165
Nociceptors enhance humoral immunity	162
Restriction factor	157
Reversing T cell immunity reveals the basis for T cell lineage fate determination	156
m1A tRNA modification facilitates rapid T cell proliferation	154
Aging lymph node responses	152
Insights into autoimmunity and cancer	152
Enhancing T cell therapy	152
Six degrees of TGFβ	151
The road not taken en route to T cell exhaustion	148
Defective fibrinolysis in periodontitis	148
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	144
Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	142
Microglia loss triggers glial stress and white matter damage in human leukodystrophy	140
Learning from inborn errors	139
Carboxylation switch	131
Beneficial role of GZMK+CD8+ T cells in neurodegeneration	130
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription	128
A polarizing answer — microglia in Nasu-Hakola disease	124
KEAP1 maintains stemness	124
A microbial iron fist to fight tumors	123
Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration	122
Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt	120
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis	116
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation	116
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	115
GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity	113
G-CSF drives autoinflammation in APLAID	112
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity	103
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis	102
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity	101
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis	101
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens	100
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants	98
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells	98
The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting	97
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	96
CAR macrophages on a fast track to solid tumor therapy	96
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19	96
JAK-STAT signaling maintains homeostasis in T cells and macrophages	95

IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines	95
Defining macrophages in the lactating murine mammary gland and human milk	94
Mucus needs GSDMD	92
2B or not 2B is the question in DC ontogeny	92
LPS structure shapes Treg cells	92
Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors	91
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice	90
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection	90
Author Correction: A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity	90
Reply to ‘Comment on: Repositioning TH cell polarization from single cytokines to complex help’	89
Three cytokine pairs modulate sepsis effects at the organism level	89
What Jane Jacobs has taught me about neuroimmunology	87
Transcriptional state and function of CD8+ memory T cells is linked to past proliferation	86
Breastfeeding induces protective T cells	85
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells	85
Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate	85
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets	84
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms	83
Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis	83
Distinct developmental pathways generate functionally distinct populations of natural killer cells	82
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation	82
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders	82
Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	82
Low-avidity T cells drive endogenous tumor immunity in mice and humans	81
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers	80
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	79
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature	77
HSCs perpetuate inflammation	76
Unraveling age-specific complexity in the human T cell compartment	76
Pregnancy stress	75
Mouse long-lived plasma cells develop from multiple origins	75
Facilitating broad antibody responses	75
Gasdermin splicing	74
B cells require exosomes	74
Meningeal damage repair	73
The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer	73
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73	72
Germinal centers FAMished without TFAM	71
Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network	71
Neuropilin-1 flags lung-resident type 2 innate lymphoid cells	70
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway	70
Monocyte-derived macrophages are too much of a good thing in lung fibrosis	70
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions	69
Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern	69
DC subsets and states unraveled across human juxtatumoral and malignant tissues	69
Specialization determines outcomes in inflammation and cancer	69
Multitier mechanics control stromal adaptations in the swelling lymph node	68
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs	68
Progress on the pathway to long COVID treatments	67
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis	67
COQ6 defies immune and metabolic expectations	67
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus	67
Gut Treg cells release IL-27 to regulate TH17 cell responses	66
c-Myb redefines the hierarchy of stem-like T cells	66
Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity	66
A second-generation M1-polarized CAR macrophage with antitumor efficacy	65
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory	65
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology	65
Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis	65
The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity	65
Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease	64
Notch gives early T cell progenitors time to grow up	64
Itaconate modifies JAK1	64
lnc(RNA)-ing myeloid metabolism	63
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis	63
Human SHARPIN deficiency is linked to inborn errors of cell death	63
Antiphage SIR2 in humans	62
Monocytes can proliferate in vacant niches before differentiation into macrophages	62
Stress-induced inflammation	62
Humanized mice for MS studies	61
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor	60
COVID-19 vaccine trials must include helminth-infected cohorts	60
Recycling dead bacteria to fuel macrophage immunometabolism	59
Y do T cells fail	59
TNF gives plasmacytoid dendritic cells a new life	59
TFH cell responses endure in human lymph nodes after vaccination	58
Towards evidence-based immunology	58
Time is of the essence for vaccine success	58
m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner	58
Inflammasome protein scaffolds the DNA damage complex during tumor development	58

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity	58
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	58
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections	57
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19	56
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition	56
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses	56
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity	55
Author Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	55
The immunoregulatory landscape of human tuberculosis granulomas	55
Anti-tumor CTLs need IL-27	55
γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors	55
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer	55
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease	54
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	54
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response	54
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia	53
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus	53
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division	53
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development	53
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling	52
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell	52
IFNλ drives diarrhea	51
Author Correction: Elusive early NK cell progenitor identified	51
PD-L1 senses fungi	51
Old and new mpox vaccine	51
Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	50
Short-range immunity	50
cGAS meets its demise in the nucleus	50
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules	50
PD-1 blockade unblocks immune responses to vaccination	50
Publisher Correction: IFNγ binding to extracellular matrix prevents fatal systemic toxicity	50
Advancements in pathogen immunity and signaling	50
The BCR-SEQC initiative	49
Unveiling the antitumor function of ID3 in liver macrophages	49
Inflammatory fibroblasts remodeling in colitis	49
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity	48
A CRISPR-based system for temporal, combinatorial gene knockout in mice	48
An anion channel for cyclic dinucleotides in T cells	48
Stress and immunity — the circuit makes the difference	47
Skin–gut crosstalk	47
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy	47
The hidden functional diversity of macrophages	47
Spatial map of microglial diversity beyond proteopathy	47
Charting new territory for T cells in pediatric lupus	46
David Baltimore (1938–2025)	45
Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation	45
Systems neuroimmunology: current bottlenecks, research priorities and future directions	45
ImmGenMaps, an open-source cartography of the immune system	45
Mechanism for controlled assembly of transcriptional condensates by Aire	45
Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1	45
Quiet custodians of CD8+ T cell fate	45
Macrophage niche availability enables local monocyte proliferation in peripheral tissues	44
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells	44
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	44
Reactivating antitumor immunity by inhibiting JMJD1C	44
The humoral response and antibodies against SARS-CoV-2 infection	43
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses	43
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development	43
Microbiota-mediated mechanisms of mucosal immunity across the lifespan	43
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	43
TH17 cell heterogeneity and its role in tissue inflammation	43
Thioredoxin is a metabolic rheostat controlling regulatory B cells	43
TCF-1 mediates chromatin intermingling during T cell development	42
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity	42
High energy, high function	42
Mitochondria controls TH17 cells	42
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	42
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease	42
Natural mouse microbes transiently block innate responses to allergens	41
Plasmacytoid dendritic cells turn red!	41
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	41
Stuart Schlossman (1935–2023)	41
Check(point) yourself before you wreck yourself in tumors	41
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	41
IL-1α in aging tumors	41
Past interactions of T cells with antigens shape CAR T cell responses	41
Modulating RNF41	41
Two CTLA-4 ligands, separate pHates	41
SLE B cells take an extrafollicular detour after mRNA vaccination	41
VDAC2 enforces a mitochondrial checkpoint to cancer immunity	41
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19	40
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis	40
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	39
T cells drive aging of the brain	39
Macrophages and fibroblasts as regulators of the immune response in pancreatic cancer	39
Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs	39
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression	39
Intestinal neuron-associated macrophages in health and disease	39
Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion	38
LARP4-mediated hypertranslation drives T cell dysfunction in tumors	38
Innate lymphoid cells and cancer	38
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	38
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling	38
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse	38
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases	38