Nature Immunology

Article	Citations
Vaccine-induced memory	1107
The delivery device of SARS-CoV-2 mucosal vaccine matters	1040
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	782
Ironman training for NK cells	624
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	563
Keeping neonatal intestines happy	526
Charting granulopoietic disturbances in sepsis	519
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	440
Imprinting tissue immunity	395
Complement profile	384
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	257
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	235
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	227
TFH cell programs by pathogen and species	227
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	215
Secretogranin 2 binds LILRB4 resulting in immunosuppression	211
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	209
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	205
A TNIP1-driven systemic autoimmune disorder with elevated IgG4	202
A little less reading, a little more type 9 action	197
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	195
Pathogenic T cells in post-viral lung disease in mice	186
Neurons protect against fibrosis	185
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	183
Astrocyte TRAIL promotes GBM	182

Lactation-associated macrophages exist in murine mammary tissue and human milk	178
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	175
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	171
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	170
CTLA-4 tail fusion enhances CAR-T antitumor immunity	168
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	166
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	166
The complexity of immune evasion mechanisms throughout the metastatic cascade	165
Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	162
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	162
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection	161
Nociceptors enhance humoral immunity	161
Restriction factor	158
Reversing T cell immunity reveals the basis for T cell lineage fate determination	156
m1A tRNA modification facilitates rapid T cell proliferation	154
Enhancing T cell therapy	152
Insights into autoimmunity and cancer	150
Aging lymph node responses	148
Six degrees of TGFβ	147
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis	147
Defective fibrinolysis in periodontitis	145
A microbial iron fist to fight tumors	143
The road not taken en route to T cell exhaustion	143
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	142
Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	139
Microglia loss triggers glial stress and white matter damage in human leukodystrophy	134
Learning from inborn errors	132
Carboxylation switch	131
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription	129
Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration	128
CAR macrophages on a fast track to solid tumor therapy	126
Beneficial role of GZMK+CD8+ T cells in neurodegeneration	125
Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt	120
KEAP1 maintains stemness	117
A polarizing answer — microglia in Nasu-Hakola disease	114
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity	113
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis	112
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens	112
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity	111
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19	108
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	108
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines	104
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	103
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells	103
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants	101
GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity	99
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis	99
JAK-STAT signaling maintains homeostasis in T cells and macrophages	99
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation	99
G-CSF drives autoinflammation in APLAID	98

Aging disrupts circadian gene regulation and function in macrophages	95
The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting	94
LPS structure shapes Treg cells	93
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets	93
Defining macrophages in the lactating murine mammary gland and human milk	93
Mucus needs GSDMD	93
2B or not 2B is the question in DC ontogeny	91
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms	91
Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	91
Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors	89
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells	88
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation	88
Reply to ‘Comment on: Repositioning TH cell polarization from single cytokines to complex help’	86
Three cytokine pairs modulate sepsis effects at the organism level	86
Role of the T cell vitamin D receptor in severe COVID-19	86
Less BMI-1 is more for chronic infections	86
What Jane Jacobs has taught me about neuroimmunology	84
Transcriptional state and function of CD8+ memory T cells is linked to past proliferation	83
Low-avidity T cells drive endogenous tumor immunity in mice and humans	82
Distinct developmental pathways generate functionally distinct populations of natural killer cells	82
Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection	82
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection	81
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers	81
Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis	81
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders	81
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice	80
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	79
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature	79
Unraveling age-specific complexity in the human T cell compartment	79
Mouse long-lived plasma cells develop from multiple origins	76
HSCs perpetuate inflammation	76
Pregnancy stress	75
B cells require exosomes	75
Facilitating broad antibody responses	75
Meningeal damage repair	74
Gasdermin splicing	74
The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer	74
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73	72
Germinal centers FAMished without TFAM	70
COQ6 defies immune and metabolic expectations	69
Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network	69
Monocyte-derived macrophages are too much of a good thing in lung fibrosis	69
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway	69
Gut Treg cells release IL-27 to regulate TH17 cell responses	68
Specialization determines outcomes in inflammation and cancer	68
Neuropilin-1 flags lung-resident type 2 innate lymphoid cells	68
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions	68
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus	67
Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern	67
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis	67
Itaconate modifies JAK1	66
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs	66
Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis	65
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	65
c-Myb redefines the hierarchy of stem-like T cells	65
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology	65
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses	64
A second-generation M1-polarized CAR macrophage with antitumor efficacy	64
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory	63
Notch gives early T cell progenitors time to grow up	63
Multitier mechanics control stromal adaptations in the swelling lymph node	63
Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity	63
Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease	63
The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity	63
Human SHARPIN deficiency is linked to inborn errors of cell death	62
Monocytes can proliferate in vacant niches before differentiation into macrophages	62
lnc(RNA)-ing myeloid metabolism	62
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis	62
TFH cell responses endure in human lymph nodes after vaccination	61
Author Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	61
Antiphage SIR2 in humans	60
Humanized mice for MS studies	60
The immunoregulatory landscape of human tuberculosis granulomas	59
Time is of the essence for vaccine success	59
COVID-19 vaccine trials must include helminth-infected cohorts	59
Inflammasome protein scaffolds the DNA damage complex during tumor development	59
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor	58
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division	58
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition	58
m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner	58

Anti-tumor CTLs need IL-27	57
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	56
TNF gives plasmacytoid dendritic cells a new life	56
Stress-induced inflammation	55
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses	55
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19	55
Recycling dead bacteria to fuel macrophage immunometabolism	55
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections	55
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer	55
Y do T cells fail	55
Towards evidence-based immunology	54
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development	54
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia	54
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity	54
γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors	54
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease	54
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus	53
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response	53
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity	53
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling	53
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	53
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell	52
Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation	52
Author Correction: Elusive early NK cell progenitor identified	52
IFNλ drives diarrhea	51
PD-L1 senses fungi	51
Author Correction: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	51
Old and new mpox vaccine	51
PD-1 blockade unblocks immune responses to vaccination	50
Publisher Correction: IFNγ binding to extracellular matrix prevents fatal systemic toxicity	49
cGAS meets its demise in the nucleus	49
Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1	49
Reactivating antitumor immunity by inhibiting JMJD1C	48
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules	48
Advancements in pathogen immunity and signaling	48
Short-range immunity	48
The BCR-SEQC initiative	47
Mechanism for controlled assembly of transcriptional condensates by Aire	47
Unveiling the antitumor function of ID3 in liver macrophages	47
Stress and immunity — the circuit makes the difference	46
A CRISPR-based system for temporal, combinatorial gene knockout in mice	46
An anion channel for cyclic dinucleotides in T cells	46
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	45
Systems neuroimmunology: current bottlenecks, research priorities and future directions	45
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development	45
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	45
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity	44
Inflammatory fibroblasts remodeling in colitis	44
Spatial map of microglial diversity beyond proteopathy	44
Microbiota-mediated mechanisms of mucosal immunity across the lifespan	44
Charting new territory for T cells in pediatric lupus	44
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy	44
Skin–gut crosstalk	44
The hidden functional diversity of macrophages	43
Thioredoxin is a metabolic rheostat controlling regulatory B cells	43
ImmGenMaps, an open-source cartography of the immune system	43
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity	42
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells	42
Macrophage niche availability enables local monocyte proliferation in peripheral tissues	42
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease	42
TCF-1 mediates chromatin intermingling during T cell development	41
TH17 cell heterogeneity and its role in tissue inflammation	41
High energy, high function	41
Mitochondria controls TH17 cells	41
The humoral response and antibodies against SARS-CoV-2 infection	41
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	41
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses	41
Natural mouse microbes transiently block innate responses to allergens	40
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	40
Check(point) yourself before you wreck yourself in tumors	40
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	40
Plasmacytoid dendritic cells turn red!	40
Modulating RNF41	40
Two CTLA-4 ligands, separate pHates	40
SLE B cells take an extrafollicular detour after mRNA vaccination	40
IL-1α in aging tumors	39
T cells drive aging of the brain	39
Past interactions of T cells with antigens shape CAR T cell responses	39
VDAC2 enforces a mitochondrial checkpoint to cancer immunity	38
Stuart Schlossman (1935–2023)	38
Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs	38
LARP4-mediated hypertranslation drives T cell dysfunction in tumors	38
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling	37
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases	37
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	37
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse	37
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	37
Distinct metabolic requirements regulate B cell activation and germinal center responses	37
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis	36
Innate immune cells link dietary cues to normal and abnormal metabolic regulation	36
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression	36
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19	36
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells	36
Controlling TRM differentiation	35
Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa	35