Nature Immunology

Article	Citations
Glucocorticoids initiate regulatory T cell and stem-cell crosstalk to grow new hair	1025
Long-term study of the human memory B cell pool reveals high stability and recurrent plasmablasts	797
Inflammatory macrophages	677
Cancer immunology leads the way	519
Mellower with age	457
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	453
The rewired immune microenvironment in leukemia	449
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	368
Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs	338
Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation	323
Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses	315
Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	305
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	304
Functional T cell tolerance by peripheral tissue-based checkpoint control	292
Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis	264
ILC1s control leukemia stem cell fate and limit development of AML	254
Bispecific antiviral neutralizing antibodies are twice as nice	224
Dangerous liaisons	220
Sensing DCs	191
The COVID-19 immunology masterclass enters its fourth year	190
Sex differences are skin deep	181
Vaccine-induced memory	167
MHC-II heterozygosity limits type 1 diabetes susceptibility through negative selection	166
TCF-1 mediates chromatin intermingling during T cell development	163
Temporal profiling of human lymphoid tissues reveals coordinated defense against viral challenge	160

ImmunOctoberfest reloaded	158
The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to control antitumor immunity	158
Distinct functions of CD4+ and CD8+ regulatory T cells in autoimmunity	155
Single-cell profiling of the immune landscape across the human lifespan	154
Anecdotes from the pandemic	153
High energy, high function	147
Delivering retinol	144
Disease trajectories	144
Genomic map of inflammatory blood proteins	143
Imprinting tissue immunity	142
Mitochondria controls TH17 cells	141
Inflammatory blood clots	138
Human and mouse peritoneal macrophages and dendritic cells compared	138
Genomic map of the cellular composition of the tumor microenvironment	137
Fructose sweetens antitumor responses	133
Modulating RNF41	132
Working towards diversity in the immunology research community	131
CD8+ TRM cells in perpetual motion	129
CTLA-4 nanobody stops colitis	128
Antigen-presenting CAFs	127
Maladaptive consequences of inflammatory events shape individual immune identity	126
Keeping neonatal intestines happy	125
Editorial Expression of Concern: The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin	125
Natural mouse microbes transiently block innate responses to allergens	125
Gene-by-environment regulation of Kupffer cell transcriptomes and epigenomes	123
Immunological signature	121
Weak enhancer allows autoactivation of Irf8 to control cDC1 versus cDC2 lineage commitment	120
IL-1α in aging tumors	120
Itaconate isomers add complexity	119
Transmission of trained immunity and heterologous resistance to infections across generations	117
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	117
Modulating bone marrow niches	115
A nasal vaccine elicits protective CD8+ T cell immunity against antigen shifted SARS-CoV-2 virus	115
Complement profile	115
Innate immune cells link dietary cues to normal and abnormal metabolic regulation	114
Pyroptotic corpses are flagged by filopodia to alert dendritic cells	112
Past interactions of T cells with antigens shape CAR T cell responses	111
Trained immunity across organs	110
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	110
Mast cell migration and organization in tissues depend on integrin–ECM interactions	109
Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction	106
The complexity of immune evasion mechanisms throughout the metastatic cascade	103
Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach	103
Excess lipids on endosomes dictate NLRP3 localization and inflammasome activation	103
Author Correction: Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development	102
Immunity after SARS-CoV-2 infections	101
Author Correction: Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development	100
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity	100
Author Correction: Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection	100
T cell exhaustion—a memory locked behind scars	96

Promise and complexity of lupus mouse models	94
Tpt1 the balance toward immunosuppression upon cell death	94
Inflating the role of stromal cells in CD8+ T cell memory	91
Mitochondrial dysfunction in the erythroid compartment	90
Thomas Alexander Waldmann (1930–2021)	89
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat	89
Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation	87
OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity	86
New functions for basophils identified in kidney fibrosis	85
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	84
Recreating immune and epithelial interactions in organoids	84
SLE B cells take an extrafollicular detour after mRNA vaccination	82
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	82
Pathogenic T cells in post-viral lung disease in mice	82
Ironman training for NK cells	81
Publisher Correction: Fiber-poor Western diets fuel inflammation	81
KSHV-encoded ORF45 activates human NLRP1 inflammasome	80
Stuart Schlossman (1935–2023)	79
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	79
The Immunological Proteome Resource	79
100 years of antibody solitude in TB	78
The delivery device of SARS-CoV-2 mucosal vaccine matters	78
Viral protein activates the NLRP1 inflammasome	77
Creating ATP via creatine kinase B for NLRP3 activation	76
Two CTLA-4 ligands, separate pHates	76
A common activator of tissue-remodeling fibroblasts across tissues	76
tRNA methylation — a new level of control for T cell immunity	75
Check(point) yourself before you wreck yourself in tumors	74
T cells drive aging of the brain	74
Exhausted intratumoral Vδ2− γδ T cells in human kidney cancer retain effector function	73
Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy	73
Tipping the balance in CD4+ T cells	72
Plasmacytoid dendritic cells turn red!	71
Mechanisms of myeloid cell entry to the healthy and diseased central nervous system	71
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	70
Author Correction: Molecular mechanisms of lineage decisions in metabolite-specific T cells	70
Charting granulopoietic disturbances in sepsis	69
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	69
NIAID workshop on T cell technologies	68
Apoptotic contraction drives target cell release by cytotoxic T cells	68
Bound to be perfect: Lck and T cell co-receptors	68
Publisher Correction: Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	66
Author Correction: T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control	65
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system	65
Publisher Correction: Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2	65
Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation	65
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	64
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	63
Nurture over nature for old antitumor T cells	63
BRWD1 orchestrates small pre-B cell chromatin topology by converting static to dynamic cohesin	63
Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation	63
Epigenetic checkpoints regulate the fate and function of CAR-T cells	62
When ceramides meet immune senescence, a GIMAP5 connection	62
FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells	62
Regulators of placental antibody transfer through a modeling lens	61
Author Correction: Selenium–GPX4 axis protects follicular helper T cells from ferroptosis	60
Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans	59
Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells	59
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	59
Affinity gaps among B cells in germinal centers drive the selection of MPER precursors	59
PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells	59
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia	58
ZBTB46 coordinates angiogenesis and immunity to control tumor outcome	58
Microbiota shape tumor immunity	57
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases	57
New fibroblast network connections support lymphocytic cellular service	57
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	56
Reply to: ‘Lack of evidence for intergenerational inheritance of immune resistance to infections’	56
Anti-fungal role for type I IFN as dectin-1 triggers non-pathogenic TH17 cell development	56
Author Correction: Macrophage function in adipose tissue homeostasis and metabolic inflammation	55
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course	55
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans	55
Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4+ T cell reservoir	55
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection	54
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells	54
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation	54
Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses	54
SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses	54
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	53
Next-generation combination approaches for immune checkpoint therapy	53

A TNIP1-driven systemic autoimmune disorder with elevated IgG4	53
Distinct metabolic requirements regulate B cell activation and germinal center responses	53
Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses	53
CTLA-4 tail fusion enhances CAR-T antitumor immunity	53
Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease	52
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	52
Nociceptor-immune interactomes reveal insult-specific immune signatures of pain	52
PI16+ reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches	52
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity	52
Human immune diversity: from evolution to modernity	52
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity	51
pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells	51
Decoding the tumor microenvironment with spatial technologies	51
Resident memory T cells develop regional dialects	51
Multimodal single-cell datasets characterize antigen-specific CD8+ T cells across SARS-CoV-2 vaccination and infection	51
Spatial proteomics of tumor microenvironments reveal why location matters	50
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	50
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease	49
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity	49
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation	49
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	49
Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion	49
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling	48
Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function	48
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology	48
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	48
Clonal structure, stability and dynamics of human memory B cells and circulating plasmablasts	48
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	48
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics	48
The neuroimmunology of social-stress-induced sensitization	48
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	47
Heme catabolism by tumor-associated macrophages controls metastasis formation	47
Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation	46
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints	46
Mapping STING	45
Eva Klein (1925–2025)	45
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	45
The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences	45
Overcoming TGFβ and activin A suppression boosts NK cell antitumor function	45
Defining blood-induced microglia functions in neurodegeneration through multiomic profiling	45
TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases	45
Peroxisomes mediate tissue repair	45
The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape	45
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance	45
Circadian control of tumor immunosuppression affects efficacy of immune checkpoint blockade	44
Divergent clonal differentiation trajectories of T cell exhaustion	44
Mitochondrial damage activates the NLRP10 inflammasome	44
Innate lymphoid cells and cancer	44
Distinct changes in endosomal composition promote NLRP3 inflammasome activation	43
Hallmarks of T cell aging	43
Navigating the path forward for evidence-based management of long COVID	42
Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis	42
Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets	42
A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity	42
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination	42
Multiplex targeting of immune-modulating genes in cancer	42
Macrophage function in adipose tissue homeostasis and metabolic inflammation	41
LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation	41
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection	41
Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families	41
Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	41
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse	40
Lactation-associated macrophages exist in murine mammary tissue and human milk	40
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	40
The integrated stress response pathway controls cytokine production in tissue-resident memory CD4+ T cells	40
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression	40
Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation	39
The T cell immune response against SARS-CoV-2	39
γδ stress detectors	38
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19	38
Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche	38
Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles	38
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer	38
Reversing T cell immunity reveals the basis for T cell lineage fate determination	37
IFN response depletes serotonin	37
Learning from inborn errors	37
A distinct subtype of stromal cell orchestrates the inflammatory response to tissue injury	37
Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8+ T cell exhaustion	36
Controlling TRM differentiation	36
The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate	36
Immune imprinting	36
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity	36
Long COVID	36
IL-3 worsens MS	35
Neuroimmunology, women scientists and dogma	35
Understanding serial killers	35
Joost J. Oppenheim (1934–2022)	34
Monocytes as targets	33
Generation of a novel synthetic CD8+ T cell state that leads to tumor control in mice	33
A protective ACPA	33
Thymus mimetic cells	33
Mediating TH17 transit	32
Vaccination prevents cognitive impairment after breakthrough infection with SARS-CoV-2	32
Allergy orchestrators	32
Self-sustaining inflammatory cycle causes memory impairment in neuropsychiatric lupus	32