Nature Immunology

Article	Citations
Vaccine-induced memory	738
Keeping neonatal intestines happy	661
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	293
Imprinting tissue immunity	289
Complement profile	287
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	281
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	264
TFH cell programs by pathogen and species	253
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity	241
Lymphocyte-derived cholinergic circuits modulate germinal center output and B cell activation	239
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	235
Ironman training for NK cells	235
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	233
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	228
Pathogenic T cells in post-viral lung disease in mice	226
Neurons protect against fibrosis	218
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	215
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	210
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	210
Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	202
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	202
CTLA-4 tail fusion enhances CAR-T antitumor immunity	201
A little less reading, a little more type 9 action	200
A TNIP1-driven systemic autoimmune disorder with elevated IgG4	191
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	186

Secretogranin 2 binds LILRB4 resulting in immunosuppression	186
Lactation-associated macrophages exist in murine mammary tissue and human milk	179
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	179
Zika immune imprint risks dengue	179
CD8+ TRM cells and lung epithelial cells crosstalk	176
Charting granulopoietic disturbances in sepsis	175
The delivery device of SARS-CoV-2 mucosal vaccine matters	168
The complexity of immune evasion mechanisms throughout the metastatic cascade	158
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	157
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	155
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	149
Astrocyte TRAIL promotes GBM	149
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	148
Nociceptors enhance humoral immunity	148
Restriction factor	143
Reversing T cell immunity reveals the basis for T cell lineage fate determination	142
m1A tRNA modification facilitates rapid T cell proliferation	139
Enhancing T cell therapy	132
Insights into autoimmunity and cancer	132
Aging lymph node responses	131
Six degrees of TGFβ	130
The road not taken en route to T cell exhaustion	126
Microglia loss triggers glial stress and white matter damage in human leukodystrophy	125
Learning from inborn errors	119
CAR macrophages on a fast track to solid tumor therapy	119
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens	115
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation	115
JAK-STAT signaling maintains homeostasis in T cells and macrophages	112
KEAP1 maintains stemness	111
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis	111
Carboxylation switch	111
A polarizing answer — microglia in Nasu-Hakola disease	110
Active aldehydes drive metabolic exhaustion in CD8+ T cells	109
A microbial iron fist to fight tumors	108
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	105
Stemness for HIV control	105
Beneficial role of GZMK+CD8+ T cells in neurodegeneration	104
Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	104
G-CSF drives autoinflammation in APLAID	103
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	101
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19	101
The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting	99
Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt	98
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants	97
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription	97
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	97
Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration	97
GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity	96
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity	93
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis	93

Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis	92
Defining macrophages in the lactating murine mammary gland and human milk	92
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity	92
2B or not 2B is the question in DC ontogeny	92
Band-Aid for antibody production	91
Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332gp120 glycan-independent epitope	89
Three cytokine pairs modulate sepsis effects at the organism level	89
Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors	87
What Jane Jacobs has taught me about neuroimmunology	87
Breastfeeding induces protective T cells	83
Author Correction: A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity	83
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells	82
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms	82
Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	81
Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate	81
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation	81
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice	80
Low-avidity T cells drive endogenous tumor immunity in mice and humans	80
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers	80
LPS structure shapes Treg cells	80
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders	79
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature	79
Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis	79
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets	78
Distinct developmental pathways generate functionally distinct populations of natural killer cells	78
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	78
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection	78
HSCs perpetuate inflammation	77
Unraveling age-specific complexity in the human T cell compartment	77
Pregnancy stress	76
Mouse long-lived plasma cells develop from multiple origins	76
Facilitating broad antibody responses	75
Gasdermin splicing	74
B cells require exosomes	74
Meningeal damage repair	74
Germinal centers FAMished without TFAM	73
Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network	73
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73	73
Progress on the pathway to long COVID treatments	73
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions	72
TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size	72
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway	72
Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease	71
Specialization determines outcomes in inflammation and cancer	70
COQ6 defies immune and metabolic expectations	69
Monocyte-derived macrophages are too much of a good thing in lung fibrosis	69
Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern	68
DC subsets and states unraveled across human juxtatumoral and malignant tissues	68
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis	68
c-Myb redefines the hierarchy of stem-like T cells	68
Author Correction: Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt	68
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology	67
The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer	67
Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy	66
Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity	66
Gut Treg cells release IL-27 to regulate TH17 cell responses	65
Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis	65
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus	65
Multitier mechanics control stromal adaptations in the swelling lymph node	65
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs	64
A second-generation M1-polarized CAR macrophage with antitumor efficacy	64
The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity	64
lnc(RNA)-ing myeloid metabolism	63
Notch gives early T cell progenitors time to grow up	63
Human SHARPIN deficiency is linked to inborn errors of cell death	63
Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes	62
Monocytes can proliferate in vacant niches before differentiation into macrophages	62
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections	62
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis	62
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia	61
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	61
Engineering Trikines	60
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses	60
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus	59
Y do T cells fail	59
Author Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	59
m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner	59
Anti-tumor CTLs need IL-27	58
Author Correction: Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology	58
Stress-induced inflammation	58

Towards evidence-based immunology	58
Recycling dead bacteria to fuel macrophage immunometabolism	58
γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors	58
Pro-tumor neural pathways	57
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling	57
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response	56
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity	55
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19	55
TFH cell responses endure in human lymph nodes after vaccination	55
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity	55
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition	54
TNF gives plasmacytoid dendritic cells a new life	54
Humanized mice for MS studies	53
Antiphage SIR2 in humans	53
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer	52
Time is of the essence for vaccine success	52
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development	52
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	52
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor	52
Inflammasome protein scaffolds the DNA damage complex during tumor development	52
IFNλ drives diarrhea	51
PD-L1 senses fungi	51
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease	51
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division	51
The BCR-SEQC initiative	50
Short-range immunity	50
A CRISPR-based system for temporal, combinatorial gene knockout in mice	50
Unveiling the antitumor function of ID3 in liver macrophages	50
cGAS meets its demise in the nucleus	50
Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation	50
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules	50
Reactivating antitumor immunity by inhibiting JMJD1C	49
David Baltimore (1938–2025)	49
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis	49
Publisher Correction: IFNγ binding to extracellular matrix prevents fatal systemic toxicity	49
Spatial map of microglial diversity beyond proteopathy	49
Quiet custodians of CD8+ T cell fate	49
Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1	49
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy	49
Inflammatory fibroblasts remodeling in colitis	48
Retraction Note: Dysregulation of CD30+ T cells by leukemia impairs isotype switching in normal B cells	48
Systems neuroimmunology: current bottlenecks, research priorities and future directions	48
Skin–gut crosstalk	48
Old and new mpox vaccine	48
Charting new territory for T cells in pediatric lupus	48
Distinct spatial organization governs oral mucosal immunity	48
Macrophage niche availability enables local monocyte proliferation in peripheral tissues	47
Stress and immunity — the circuit makes the difference	47
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease	46
The hidden functional diversity of macrophages	46
PD-1 blockade unblocks immune responses to vaccination	46
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development	46
Sex differences in immune responses to viruses, bacteria and vaccines	46
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell	46
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	46
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells	46
Advancements in pathogen immunity and signaling	46
TH17 cell heterogeneity and its role in tissue inflammation	45
Microbiota-mediated mechanisms of mucosal immunity across the lifespan	45
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	44
Thioredoxin is a metabolic rheostat controlling regulatory B cells	44
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity	44
Mechanism for controlled assembly of transcriptional condensates by Aire	43
The humoral response and antibodies against SARS-CoV-2 infection	43
Author Correction: Elusive early NK cell progenitor identified	43
ImmGenMaps, an open-source cartography of the immune system	43
TCF-1 mediates chromatin intermingling during T cell development	42
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	42
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses	42
Modulating RNF41	42
Mitochondria controls TH17 cells	42
Natural mouse microbes transiently block innate responses to allergens	42
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	41
Two CTLA-4 ligands, separate pHates	41
Plasmacytoid dendritic cells turn red!	41
Check(point) yourself before you wreck yourself in tumors	41
IL-1α in aging tumors	40
SLE B cells take an extrafollicular detour after mRNA vaccination	40
VDAC2 enforces a mitochondrial checkpoint to cancer immunity	40
Past interactions of T cells with antigens shape CAR T cell responses	40
Stuart Schlossman (1935–2023)	40
T cells in cerebrospinal fluid support a suspected viral link to multiple sclerosis	39
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells	39
Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19	39
Intestinal neuron-associated macrophages in health and disease	39
Maternal allergy and infection promote asthma	39
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	39
Yin and yang of tumor-associated macrophages	39
Type 2 cytokines in the thymus activate Sirpα+ dendritic cells to promote clonal deletion	39
Distinct metabolic requirements regulate B cell activation and germinal center responses	38
LARP4-mediated hypertranslation drives T cell dysfunction in tumors	38
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	38
Innate immune cells link dietary cues to normal and abnormal metabolic regulation	38
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	37
T cells drive aging of the brain	37