Nature Immunology

Article	Citations
Vaccine-induced memory	708
3D imaging of the synovium defines an immune defense system at the blood–joint barrier	335
Imprinting tissue immunity	331
Complement profile	325
Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy	312
Two-birds-one-stone approach to combine protein and mRNA vaccines for COVID-19	271
Pathogenic T cells in post-viral lung disease in mice	269
Neurons protect against fibrosis	268
TFH cell programs by pathogen and species	267
Ironman training for NK cells	265
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption	252
CD8+ TRM cells and lung epithelial cells crosstalk	246
Zika immune imprint risks dengue	242
A little less reading, a little more type 9 action	233
The delivery device of SARS-CoV-2 mucosal vaccine matters	229
Charting granulopoietic disturbances in sepsis	214
Inhibition of salt-inducible kinases reprograms T cells and antitumor immunity in ovarian cancer	213
Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection	213
A TNIP1-driven systemic autoimmune disorder with elevated IgG4	211
Keeping neonatal intestines happy	207
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes	204
Lymphocyte-derived cholinergic circuits modulate germinal center output and B cell activation	197
Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells	194
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1	189
Secretogranin 2 binds LILRB4 resulting in immunosuppression	187

Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke	187
Astrocyte TRAIL promotes GBM	172
PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self	171
The complexity of immune evasion mechanisms throughout the metastatic cascade	170
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity	168
Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice	168
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function	167
CTLA-4 tail fusion enhances CAR-T antitumor immunity	166
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation	163
Lactation-associated macrophages exist in murine mammary tissue and human milk	160
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease	153
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states	150
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	147
Nociceptors enhance humoral immunity	144
Restriction factor	143
m1A tRNA modification facilitates rapid T cell proliferation	140
Enhancing T cell therapy	139
Insights into autoimmunity and cancer	134
The road not taken en route to T cell exhaustion	128
Microglia loss triggers glial stress and white matter damage in human leukodystrophy	127
Learning from inborn errors	125
Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens	121
Carboxylation switch	119
KEAP1 maintains stemness	119
A polarizing answer — microglia in Nasu-Hakola disease	118
A microbial iron fist to fight tumors	117
Active aldehydes drive metabolic exhaustion in CD8+ T cells	117
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	117
E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription	117
Stemness for HIV control	116
G-CSF drives autoinflammation in APLAID	116
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	114
Beneficial role of GZMK+CD8+ T cells in neurodegeneration	112
Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration	110
Enzymatic cleavage weaponizes bacterial lipoproteins into immune tripwires	110
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation	109
Six degrees of TGFβ	108
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19	107
Costimulation drives CAR-T cell division fate	105
Publisher Correction: PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape	103
GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity	102
The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis	100
Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity	100
CAR macrophages on a fast track to solid tumor therapy	99
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	98
The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting	97
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis	97
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis	95
JAK-STAT signaling maintains homeostasis in T cells and macrophages	95
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity	95

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants	95
Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt	94
Defining macrophages in the lactating murine mammary gland and human milk	93
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation	92
Three cytokine pairs modulate sepsis effects at the organism level	91
What Jane Jacobs has taught me about neuroimmunology	90
Author Correction: Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors	88
Breastfeeding induces protective T cells	88
Author Correction: A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity	88
LPS structure shapes Treg cells	87
Band-Aid for antibody production	87
Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases	86
Distinct developmental pathways generate functionally distinct populations of natural killer cells	86
An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms	86
2B or not 2B is the question in DC ontogeny	86
A temporal map of B cell diversification mechanisms in mice	85
Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice	84
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets	84
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection	83
Sequential lymphotoxin-β receptor and retinoic acid receptor signals regulate cDC2 fate	82
Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature	82
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	82
Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332gp120 glycan-independent epitope	80
Low-avidity T cells drive endogenous tumor immunity in mice and humans	79
Novel mouse models based on intersectional genetics to identify and characterize plasmacytoid dendritic cells	79
Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis	78
Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms	78
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders	76
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers	76
Mouse long-lived plasma cells develop from multiple origins	75
Unraveling age-specific complexity in the human T cell compartment	75
Gasdermin splicing	74
Pregnancy stress	74
Meningeal damage repair	73
Germinal centers FAMished without TFAM	72
Immune tolerance in peripheral CD4+ T cells is cooperatively regulated by PD-1 and CD73	72
Author Correction: Long-term retention of antigens in germinal centers is controlled by the spatial organization of the follicular dendritic cell network	71
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway	71
Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions	70
Progress on the pathway to long COVID treatments	69
COQ6 defies immune and metabolic expectations	69
Monocyte-derived macrophages are too much of a good thing in lung fibrosis	69
Facilitating broad antibody responses	68
Author Correction: Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt	68
Impaired CD4+ T cell recognition of SARS-CoV-2 variants of concern	68
c-Myb redefines the hierarchy of stem-like T cells	68
Specialization determines outcomes in inflammation and cancer	67
Gut Treg cells release IL-27 to regulate TH17 cell responses	67
Developmentally programmed early-age skin localization of iNKT cells supports local tissue development and homeostasis	66
The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer	66
Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology	66
Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy	65
Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis	65
Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus	65
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs	65
DC subsets and states unraveled across human juxtatumoral and malignant tissues	63
ILC2 influence pancreatic fibroblasts	62
Human lungs maintain tissue-resident memory T cells against a broad spectrum of pathogens	62
The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity	62
A second-generation M1-polarized CAR macrophage with antitumor efficacy	62
Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity	61
lnc(RNA)-ing myeloid metabolism	61
TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size	61
Human SHARPIN deficiency is linked to inborn errors of cell death	61
Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease	61
Pyoderma gangrenosum caused by the molecular uncoupling of OTULIN catalytic activity and LUBAC binding	61
Notch gives early T cell progenitors time to grow up	61
Antiphage SIR2 in humans	60
Humanized mice for MS studies	60
Towards evidence-based immunology	59
Engineering Trikines	59
Stress-induced inflammation	59
Anti-tumor CTLs need IL-27	59
TFH cell responses endure in human lymph nodes after vaccination	59
Author Correction: Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology	58
Author Correction: CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions	58
Pro-tumor neural pathways	58
Y do T cells fail	58
Recycling dead bacteria to fuel macrophage immunometabolism	57
γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors	57

m6A RNA modification regulates innate lymphoid cell responses in a lineage-specific manner	57
TNF gives plasmacytoid dendritic cells a new life	57
UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling	57
Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development	57
Time is of the essence for vaccine success	57
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor	56
Regulatory factor X 7 limits Myc activity during B cell activation and suppresses Myc-dependent lymphomagenesis	56
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections	56
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity	56
Differential assembly of mouse and human tumor microenvironments	56
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease	56
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia	55
Monocytes can proliferate in vacant niches before differentiation into macrophages	55
Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes	55
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response	55
Thymic alveolar type 2 epithelial mimetic cells revealed by RUNX1 deficiency	54
Inflammasome protein scaffolds the DNA damage complex during tumor development	54
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia	54
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity	54
β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus	54
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	52
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer	52
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19	52
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses	52
cGAS meets its demise in the nucleus	51
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division	51
IFNλ drives diarrhea	51
PD-L1 senses fungi	51
Pas de deux of NLRP3 and ASC with CD63 on mast cell granules	50
Short-range immunity	50
Advancements in pathogen immunity and signaling	49
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development	49
The BCR-SEQC initiative	49
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell	49
Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation	49
Publisher Correction: Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy	49
Author Correction: Elusive early NK cell progenitor identified	48
A CRISPR-based system for temporal, combinatorial gene knockout in mice	48
ImmGenMaps, an open-source cartography of the immune system	48
Quiet custodians of CD8+ T cell fate	47
Inflammatory fibroblasts remodeling in colitis	47
David Baltimore (1938–2025)	47
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy	47
Retraction Note: Dysregulation of CD30+ T cells by leukemia impairs isotype switching in normal B cells	47
Publisher Correction: IFNγ binding to extracellular matrix prevents fatal systemic toxicity	47
Old and new mpox vaccine	47
Macrophage niche availability enables local monocyte proliferation in peripheral tissues	47
Skin–gut crosstalk	47
Systems neuroimmunology: current bottlenecks, research priorities and future directions	47
Distinct spatial organization governs oral mucosal immunity	47
Spatial map of microglial diversity beyond proteopathy	47
Charting new territory for T cells in pediatric lupus	47
OXPHOS fuels cDC1s	46
Fed T cells	46
Simultaneous STING and lymphotoxin-β receptor activation induces B cell responses in tertiary lymphoid structures to potentiate antitumor immunity	45
The hidden functional diversity of macrophages	45
Adaptive immunity in the pathogenesis of neurodegeneration	45
Reactivating antitumor immunity by inhibiting JMJD1C	45
A new ‘K’ind of T helper cell	45
Unveiling the antitumor function of ID3 in liver macrophages	44
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease	44
Mechanism for controlled assembly of transcriptional condensates by Aire	44
Microbiota-mediated mechanisms of mucosal immunity across the lifespan	44
Thioredoxin is a metabolic rheostat controlling regulatory B cells	44
Sex differences in immune responses to viruses, bacteria and vaccines	43
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells	43
TH17 cell heterogeneity and its role in tissue inflammation	43
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	43
Mapping self-associating chromatin hubs identifies Id proteins as key determinants of exhausted CD8+ T cell fate	43
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis	43
Publisher Correction: Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1	43
Inflammatory immune modulators of AML lung infiltration and respiratory failure	43
Natural mouse microbes transiently block innate responses to allergens	42
Modulating RNF41	42
Nanotech unveils cytokine traces in post-COVID cardiovascular complications	42
Mitochondria controls TH17 cells	42
Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia	41
SLE B cells take an extrafollicular detour after mRNA vaccination	41
IL-1α in aging tumors	41
Check(point) yourself before you wreck yourself in tumors	41
Yin and yang of tumor-associated macrophages	41
Stuart Schlossman (1935–2023)	41
Plasmacytoid dendritic cells turn red!	41
Past interactions of T cells with antigens shape CAR T cell responses	41
Endothelial cell-intrinsic NOD2 signaling regulates the intestinal immune response through the generation of effector and memory T cells	40
Affinity maturation of AAN-I-IFNs	40
ETS1 is a key transcription factor that drives RANKL-expressing, tissue-destructive fibroblasts	40
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse	40
Maternal allergy and infection promote asthma	40
T cells in cerebrospinal fluid support a suspected viral link to multiple sclerosis	40
T cells drive aging of the brain	40
Two CTLA-4 ligands, separate pHates	40
Innate immune cells link dietary cues to normal and abnormal metabolic regulation	39
VDAC2 enforces a mitochondrial checkpoint to cancer immunity	39
Intestinal neuron-associated macrophages in health and disease	39