Nature Immunology

Article	Citations
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19	987
The T cell immune response against SARS-CoV-2	779
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function	717
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation	556
Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19	533
Single-cell landscape of immunological responses in patients with COVID-19	494
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection	472
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition	447
Immunogenic cell stress and death	443
NLRP3 inflammasome in cancer and metabolic diseases	437
The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies	422
Pathological sequelae of long-haul COVID	400
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum	376
Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison	375
Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection	367
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion	362
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines	360
Innate immunity: the first line of defense against SARS-CoV-2	309
The immunology of rheumatoid arthritis	294
Autoimmunity and organ damage in systemic lupus erythematosus	290
Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection	279
Trained immunity, tolerance, priming and differentiation: distinct immunological processes	275
Climate change: an enduring challenge for vector-borne disease prevention and control	274
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion	251
The RNA modification N6-methyladenosine as a novel regulator of the immune system	250

The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies	241
Extracellular vesicles in immunomodulation and tumor progression	233
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen	227
Proinflammatory IgG Fc structures in patients with severe COVID-19	226
Microglia use TAM receptors to detect and engulf amyloid β plaques	224
Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons	221
Hallmarks of T cell aging	220
Mapping systemic lupus erythematosus heterogeneity at the single-cell level	213
Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy	212
The complex role of tumor-infiltrating macrophages	201
ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection	193
A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance	192
Redox homeostasis maintained by GPX4 facilitates STING activation	188
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine	187
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity	185
Novel Hexb-based tools for studying microglia in the CNS	182
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines	180
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms	178
Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity	171
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor	167
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells	167
The mesenchymal context in inflammation, immunity and cancer	164
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans	163
Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity	160
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis	156
Early precursor T cells establish and propagate T cell exhaustion in chronic infection	154
Establishment of an African green monkey model for COVID-19 and protection against re-infection	148
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells	147
Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal	146
Environmental pollutants and the immune response	146
Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity	139
A new neutrophil subset promotes CNS neuron survival and axon regeneration	139
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection	139
Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis	128
Regulation and modulation of antitumor immunity in pancreatic cancer	125
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans	124
Dynamics in protein translation sustaining T cell preparedness	121
Inflammasomes and adaptive immune responses	120
Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation	117
Does tissue imprinting restrict macrophage plasticity?	117
Neuroinflammation after surgery: from mechanisms to therapeutic targets	117
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes	115
Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity	114
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells	113
Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression	113
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity	112
Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation	112
Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses	111
Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells	111
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation	110

An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease	109
ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung	109
The immunoregulatory landscape of human tuberculosis granulomas	109
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation	108
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection	107
The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape	107
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis	105
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells	104
Immunology of SARS-CoV-2 infection in children	101
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments	99
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens	99
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules	98
The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development	98
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity	98
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma	97
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection	96
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects	95
Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19	94
Repositioning TH cell polarization from single cytokines to complex help	92
The commensal skin microbiota triggers type I IFN–dependent innate repair responses in injured skin	91
Immune cell compartmentalization for brain surveillance and protection	91
Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis	89
Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs	89
The humoral response and antibodies against SARS-CoV-2 infection	86
Epigenetic regulation of T cell exhaustion	86
Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly	85
Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity	84
Distinct transcription factor networks control neutrophil-driven inflammation	84
Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments	84
Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection	83
STEEP mediates STING ER exit and activation of signaling	82
Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression	81
Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits	81
Remodeling of light and dark zone follicular dendritic cells governs germinal center responses	81
Inefficient CAR-proximal signaling blunts antigen sensitivity	81
BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection	79
Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states	78
Lessons learned: new insights on the role of cytokines in COVID-19	77
Delayed-interval BNT162b2 mRNA COVID-19 vaccination enhances humoral immunity and induces robust T cell responses	77
Innate lymphoid cells and cancer	75
BATF3 programs CD8+ T cell memory	75
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells	75
Cxcl10+ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation	74
Peripherally induced brain tissue–resident memory CD8+ T cells mediate protection against CNS infection	72
The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge	72
PERK is a critical metabolic hub for immunosuppressive function in macrophages	72
Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19	71
Transmission of trained immunity and heterologous resistance to infections across generations	71
Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity	70
A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals	70
Tumor hypoxia represses γδ T cell-mediated antitumor immunity against brain tumors	70
Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin	70
Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function	67
IRGM1 links mitochondrial quality control to autoimmunity	66
Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria	66
A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma	66
The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate	65
Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung	64
Human immune diversity: from evolution to modernity	64
Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands	64
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory	63
Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation	63
Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells	63
Significance of bystander T cell activation in microbial infection	62
Superior immunogenicity and effectiveness of the third compared to the second BNT162b2 vaccine dose	62
Novel specialized cell state and spatial compartments within the germinal center	62
Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes	62
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity	62
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics	62
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation	61
Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy	61
Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation	61
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins	60
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation	60
Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity	60
Aging disrupts circadian gene regulation and function in macrophages	59
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer	59
Heme catabolism by tumor-associated macrophages controls metastasis formation	58
Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization	58
Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication	58

The cellular architecture of the antimicrobial response network in human leprosy granulomas	58
Functional CRISPR dissection of gene networks controlling human regulatory T cell identity	57
Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity	56
Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress	56
Naturalizing mouse models for immunology	56
Eomes identifies thymic precursors of self-specific memory-phenotype CD8+ T cells	55
LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation	55
Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues	55
The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic–epigenetic reprogramming and resolves inflammatory injury	55
T cells in COVID-19 — united in diversity	55
IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation	55
NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting	54
Fibroblasts as a source of self-antigens for central immune tolerance	54
Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition	54
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells	54
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity	53
γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis	53
Microbial metabolism of l-tyrosine protects against allergic airway inflammation	53
Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques	53
The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection	52
Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease	52
ImmGen at 15	51
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses	51
RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus	51
Tissue adaptation and clonal segregation of human memory T cells in barrier sites	50
Making innate sense of mRNA vaccine adjuvanticity	49
Transposon-triggered innate immune response confers cancer resistance to the blind mole rat	48
Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses	47
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection	47
mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates	47
Divergent clonal differentiation trajectories of T cell exhaustion	47
Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity	47
SARS-CoV-2 takes its Toll	46
Circadian clocks guide dendritic cells into skin lymphatics	46
Clonal expansion and epigenetic inheritance of long-lasting NK cell memory	46
Cascading risks of waterborne diseases from climate change	46
The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity	45
The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING–IFN-β pathway	44
Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues	44
Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells	44
Surface phenotypes of naive and memory B cells in mouse and human tissues	44
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation	44
Dynamic regulation of B cell complement signaling is integral to germinal center responses	44
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B	44
Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory	43
Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis	43
Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion	42
Environmental allergens trigger type 2 inflammation through ripoptosome activation	42
Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development	42
The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis	42
Insulin signaling establishes a developmental trajectory of adipose regulatory T cells	42
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination	42
An updated guide for the perplexed: cytometry in the high-dimensional era	42
Chd4 choreographs self-antigen expression for central immune tolerance	42
TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer	41
CD4+ T cell memory	41
Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome	41
Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses	40
TH17 cell heterogeneity and its role in tissue inflammation	40
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection	40
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy	40
The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling	40
Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory	39
BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S2	39
Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations	39
Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development	39
Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer	39
Early emergence of T central memory precursors programs clonal dominance during chronic viral infection	39
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses	39
Wnt–β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression	39
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19	38
Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies	38
Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation	38
Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes	38
Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis	38
tRNA-m1A modification promotes T cell expansion via efficient MYC protein synthesis	38
Distinct changes in endosomal composition promote NLRP3 inflammasome activation	38
An engineered bispecific human monoclonal antibody against SARS-CoV-2	37
Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells	37
Neutrophils direct preexisting matrix to initiate repair in damaged tissues	37
High-throughput and high-dimensional single-cell analysis of antigen-specific CD8+ T cells	37
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity	36
Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation	36
Clonal structure, stability and dynamics of human memory B cells and circulating plasmablasts	36
Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate	36
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine	36
TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis	36
Taiwan’s experience in fighting COVID-19	36
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course	36
Dichotomous metabolic networks govern human ILC2 proliferation and function	35
Fibroblastic reticular cell lineage convergence in Peyer’s patches governs intestinal immunity	35
Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression	35
Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs	35
In situ neutrophil efferocytosis shapes T cell immunity to influenza infection	35
Targeting TFH cells in human diseases and vaccination: rationale and practice	35